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Ewan St. John Smith, MPharmacol., PhD - Publications

Affiliations: 
University of Cambridge, Cambridge, England, United Kingdom 
Area:
Sensory transduction, ion channels, naked mole-rats, pain
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42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Dulai JS, Smith ESJ, Rahman T. Acid-Sensing Ion Channel 3: An Analgesic Target. Channels (Austin, Tex.). PMID 33258401 DOI: 10.1080/19336950.2020.1852831  1
2020 Du Z, Chakrabarti S, Kulaberoglu Y, Smith ESJ, Dobson CM, Itzhaki LS, Kumita JR. Probing the unfolded protein response in long-lived naked mole-rats. Biochemical and Biophysical Research Communications. 529: 1151-1157. PMID 32819579 DOI: 10.1016/j.bbrc.2020.06.118  0.76
2020 Chakrabarti S, Ai M, Henson FMD, Smith ESJ. Peripheral mechanisms of arthritic pain: A proposal to leverage large animals for studies. Neurobiology of Pain (Cambridge, Mass.). 8: 100051. PMID 32817908 DOI: 10.1016/j.ynpai.2020.100051  0.76
2020 Lee MC, Nahorski MS, Hockley JRF, Lu VB, Ison G, Pattison LA, Callejo G, Stouffer K, Fletcher E, Brown C, Drissi I, Wheeler D, Ernfors P, Menon D, Reimann F, ... Smith ESJ, et al. Human Labor Pain Is Influenced by the Voltage-Gated Potassium Channel K6.4 Subunit. Cell Reports. 32: 107941. PMID 32697988 DOI: 10.1016/j.celrep.2020.107941  1
2020 Hadi F, Kulaberoglu Y, Lazarus KA, Bach K, Ugur R, Beattie P, Smith ESJ, Khaled WT. Transformation of naked mole-rat cells. Nature. 583: E1-E7. PMID 32612221 DOI: 10.1038/s41586-020-2410-x  0.32
2020 St John Smith E, Park TJ. Neurobiology: Crowdsourcing CO to Conserve Brain Energy. Current Biology : Cb. 30: R649-R651. PMID 32516615 DOI: 10.1016/j.cub.2020.04.009  0.84
2020 Browe BM, Olsen AR, Ramirez C, Rickman RH, Smith ESJ, Park TJ. The naked mole-rat has a functional purinergic pain pathway despite having a non-functional peptidergic pain pathway. Neurobiology of Pain (Cambridge, Mass.). 8: 100047. PMID 32478202 DOI: 10.1016/j.ynpai.2020.100047  1
2020 Chakrabarti S, Pattison LA, Doleschall B, Rickman RH, Blake H, Callejo G, Heppenstall PA, Smith ESJ. Intra-articular AAV-PHP.S mediated chemogenetic targeting of knee-innervating dorsal root ganglion neurons alleviates inflammatory pain in mice. Arthritis & Rheumatology (Hoboken, N.J.). PMID 32418284 DOI: 10.1002/art.41314  1
2020 Chakrabarti S, Hore Z, Pattison LA, Lalnunhlimi S, Bhebhe CN, Callejo G, Bulmer DC, Taams LS, Denk F, St John Smith E. Sensitization of knee-innervating sensory neurons by tumor necrosis factor-α activated fibroblast-like synoviocytes: an in vitro, co-culture model of inflammatory pain. Pain. PMID 32332252 DOI: 10.1097/j.pain.0000000000001890  0.4
2020 Callejo G, Pattison LA, Greenhalgh JC, Chakrabarti S, Andreopoulou E, Hockley JRF, Smith ESJ, Rahman T. In silico screening of GMQ-like compounds reveals guanabenz and sephin1 as new allosteric modulators of acid-sensing ion channel 3. Biochemical Pharmacology. 113834. PMID 32027884 DOI: 10.1016/j.bcp.2020.113834  1
2020 Hockley JR, Barker KH, Taylor TS, Callejo G, Husson ZM, Bulmer DC, Smith ESJ. Acid and inflammatory sensitisation of naked mole-rat colonic afferent nerves. Molecular Pain. 16: 1744806920903150. PMID 31992138 DOI: 10.1177/1744806920903150  0.76
2020 Taylor TS, Konda P, John SS, Bulmer DC, Hockley JRF, Smith ESJ. Galanin suppresses visceral afferent responses to noxious mechanical and inflammatory stimuli. Physiological Reports. 8: e14326. PMID 31960596 DOI: 10.14814/phy2.14326  0.76
2019 Chakrabarti S, Jadon DR, Bulmer DC, Smith ESJ. Human osteoarthritic synovial fluid increases excitability of mouse dorsal root ganglion sensory neurons: an in-vitro translational model to study arthritic pain. Rheumatology (Oxford, England). PMID 31410487 DOI: 10.1093/rheumatology/kez331  0.76
2019 Kulaberoglu Y, Bhushan B, Hadi F, Chakrabarti S, Khaled WT, Rankin KS, Smith ESJ, Frankel D. The material properties of naked mole-rat hyaluronan. Scientific Reports. 9: 6632. PMID 31036852 DOI: 10.1038/s41598-019-43194-7  0.76
2018 Bautzova T, Hockley JRF, Perez-Berezo T, Pujo J, Tranter MM, Desormeaux C, Barbaro MR, Basso L, Le Faouder P, Rolland C, Malapert P, Moqrich A, Eutamene H, Denadai-Souza A, Vergnolle N, ... Smith ESJ, et al. 5-oxoETE triggers nociception in constipation-predominant irritable bowel syndrome through MAS-related G protein-coupled receptor D. Science Signaling. 11. PMID 30563864 DOI: 10.1126/scisignal.aal2171  0.76
2018 Hockley JRF, Smith ESJ, Bulmer DC. Human visceral nociception: findings from translational studies in human tissue. American Journal of Physiology. Gastrointestinal and Liver Physiology. PMID 29848022 DOI: 10.1152/ajpgi.00398.2017  0.76
2018 Wright AJ, Husson ZMA, Hu DE, Callejo G, Brindle KM, Smith ESJ. Increased hyperpolarized [1-13 C] lactate production in a model of joint inflammation is not accompanied by tissue acidosis as assessed using hyperpolarized 13 C-labelled bicarbonate. Nmr in Biomedicine. PMID 29380927 DOI: 10.1002/nbm.3892  0.76
2017 Prato V, Taberner FJ, Hockley JRF, Callejo G, Arcourt A, Tazir B, Hammer L, Schad P, Heppenstall PA, Smith ES, Lechner SG. Functional and Molecular Characterization of Mechanoinsensitive "Silent" Nociceptors. Cell Reports. 21: 3102-3115. PMID 29241539 DOI: 10.1016/j.celrep.2017.11.066  1
2017 Schuhmacher LN, Callejo G, Srivats S, Smith ESJ. Naked mole-rat acid-sensing ion channel 3 forms nonfunctional homomers, but functional heteromers. The Journal of Biological Chemistry. PMID 29237731 DOI: 10.1074/jbc.M117.807859  1
2017 Park TJ, Reznick J, Peterson BL, Blass G, Omerbašić D, Bennett NC, Kuich PHJL, Zasada C, Browe BM, Hamann W, Applegate DT, Radke MH, Kosten T, Lutermann H, Gavaghan V, ... ... Smith ESJ, et al. Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat. Science (New York, N.Y.). 356: 307-311. PMID 28428423 DOI: 10.1126/science.aab3896  1
2016 Wetzel C, Pifferi S, Picci C, Gök C, Hoffmann D, Bali KK, Lampe A, Lapatsina L, Fleischer R, Smith ES, Bégay V, Moroni M, Estebanez L, Kühnemund J, Walcher J, et al. Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nature Neuroscience. PMID 27941788 DOI: 10.1038/nn.4454  1
2016 da Silva Serra I, Husson Z, Bartlett JD, Smith ES. Characterization of cutaneous and articular sensory neurons. Molecular Pain. 12. PMID 27030722 DOI: 10.1177/1744806916636387  0.68
2015 Schuhmacher LN, Srivats S, Smith ES. Structural domains underlying the activation of acid-sensing ion channel 2a. Molecular Pharmacology. 87: 561-71. PMID 25583083 DOI: 10.1124/mol.114.096909  0.84
2015 Omerbaši? D, Schuhmacher LN, Bernal Sierra YA, Smith ES, Lewin GR. ASICs and mammalian mechanoreceptor function. Neuropharmacology. 94: 80-86. PMID 25528740 DOI: 10.1016/j.neuropharm.2014.12.007  1
2014 Rahman T, Smith ES. In silico assessment of interaction of sea anemone toxin APETx2 and acid sensing ion channel 3. Biochemical and Biophysical Research Communications. 450: 384-9. PMID 24942880 DOI: 10.1016/j.bbrc.2014.05.130  1
2014 Lewin GR, Lechner SG, Smith ES. Nerve growth factor and nociception: from experimental embryology to new analgesic therapy. Handbook of Experimental Pharmacology. 220: 251-82. PMID 24668476 DOI: 10.1007/978-3-642-45106-5_10  1
2014 Kozlenkov A, Lapatsina L, Lewin GR, Smith ES. Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1. The Journal of Physiology. 592: 557-69. PMID 24247984 DOI: 10.1113/jphysiol.2013.258657  1
2013 Smith ES, Martinez-Velazquez L, Ringstad N. A chemoreceptor that detects molecular carbon dioxide. The Journal of Biological Chemistry. 288: 37071-81. PMID 24240097 DOI: 10.1074/jbc.M113.517367  1
2012 Brand J, Smith ES, Schwefel D, Lapatsina L, Poole K, OmerbaÅ¡ić D, Kozlenkov A, Behlke J, Lewin GR, Daumke O. A stomatin dimer modulates the activity of acid-sensing ion channels. The Embo Journal. 31: 3635-46. PMID 22850675 DOI: 10.1038/emboj.2012.203  1
2012 Stock K, Kumar J, Synowitz M, Petrosino S, Imperatore R, Smith ES, Wend P, Purfürst B, Nuber UA, Gurok U, Matyash V, Wälzlein JH, Chirasani SR, Dittmar G, Cravatt BF, et al. Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1. Nature Medicine. 18: 1232-8. PMID 22820645 DOI: 10.1038/nm.2827  1
2012 Lapatsina L, Jira JA, Smith ES, Poole K, Kozlenkov A, Bilbao D, Lewin GR, Heppenstall PA. Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons. Open Biology. 2: 120096. PMID 22773952 DOI: 10.1098/rsob.120096  1
2012 St John Smith E, Purfürst B, Grigoryan T, Park TJ, Bennett NC, Lewin GR. Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of Bathyergidae. The Journal of Comparative Neurology. 520: 2785-803. PMID 22528859 DOI: 10.1002/cne.23133  0.56
2011 Smith ES, OmerbaÅ¡ić D, Lechner SG, Anirudhan G, Lapatsina L, Lewin GR. The molecular basis of acid insensitivity in the African naked mole-rat. Science (New York, N.Y.). 334: 1557-60. PMID 22174253 DOI: 10.1126/science.1213760  1
2011 Lechner SG, Markworth S, Poole K, Smith ES, Lapatsina L, Frahm S, May M, Pischke S, Suzuki M, Ibañez-Tallon I, Luft FC, Jordan J, Lewin GR. The molecular and cellular identity of peripheral osmoreceptors. Neuron. 69: 332-44. PMID 21262470 DOI: 10.1016/j.neuron.2010.12.028  1
2010 Brand A, Smith ES, Lewin GR, Park TJ. Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat. Plos One. 5: e15162. PMID 21200438 DOI: 10.1371/journal.pone.0015162  0.96
2010 Smith ES, Blass GR, Lewin GR, Park TJ. Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P. Molecular Pain. 6: 29. PMID 20497578 DOI: 10.1186/1744-8069-6-29  1
2010 Stürzebecher AS, Hu J, Smith ES, Frahm S, Santos-Torres J, Kampfrath B, Auer S, Lewin GR, Ibañez-Tallon I. An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors. The Journal of Physiology. 588: 1695-707. PMID 20308253 DOI: 10.1113/jphysiol.2010.187112  1
2009 Smith ES, Lewin GR. Nociceptors: a phylogenetic view. Journal of Comparative Physiology. a, Neuroethology, Sensory, Neural, and Behavioral Physiology. 195: 1089-106. PMID 19830434 DOI: 10.1007/s00359-009-0482-z  1
2008 Park TJ, Lu Y, Jüttner R, Smith ES, Hu J, Brand A, Wetzel C, Milenkovic N, Erdmann B, Heppenstall PA, Laurito CE, Wilson SP, Lewin GR. Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber). Plos Biology. 6: e13. PMID 18232734 DOI: 10.1371/journal.pbio.0060013  1
2007 Cadiou H, Studer M, Jones NG, Smith ES, Ballard A, McMahon SB, McNaughton PA. Modulation of acid-sensing ion channel activity by nitric oxide. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 13251-60. PMID 18045919 DOI: 10.1523/JNEUROSCI.2135-07.2007  1
2007 Smith ES, Zhang X, Cadiou H, McNaughton PA. Proton binding sites involved in the activation of acid-sensing ion channel ASIC2a. Neuroscience Letters. 426: 12-7. PMID 17881127 DOI: 10.1016/j.neulet.2007.07.047  1
2007 Smith ES, Cadiou H, McNaughton PA. Arachidonic acid potentiates acid-sensing ion channels in rat sensory neurons by a direct action. Neuroscience. 145: 686-98. PMID 17258862 DOI: 10.1016/j.neuroscience.2006.12.024  1
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