Gary R. Lewin - Publications

Max-Delbrück Center for Molecular Medicine, Berlin, Berlin, Berlin, Germany 
Sensory transduction, molecular mechanisms, ion channels

145 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Schwaller F, Bégay V, García-García G, Taberner FJ, Moshourab R, McDonald B, Docter T, Kühnemund J, Ojeda-Alonso J, Paricio-Montesinos R, Lechner SG, Poulet JFA, Millan JM, Lewin GR. USH2A is a Meissner's corpuscle protein necessary for normal vibration sensing in mice and humans. Nature Neuroscience. PMID 33288907 DOI: 10.1038/s41593-020-00751-y  1
2020 Agarwal N, Taberner FJ, Rangel Rojas D, Moroni M, Omberbasic D, Njoo C, Andrieux A, Gupta P, Bali KK, Herpel E, Faghihi F, Fleming T, Dejean A, Lechner SG, Nawroth PP, ... Lewin GR, et al. SUMOylation of Enzymes and Ion Channels in Sensory Neurons Protects against Metabolic Dysfunction, Neuropathy, and Sensory Loss in Diabetes. Neuron. PMID 32735781 DOI: 10.1016/j.neuron.2020.06.037  1
2020 Patkunarajah A, Stear JH, Moroni M, Schroeter L, Blaszkiewicz J, Tearle JL, Cox CD, Fuerst C, Sanchez-Carranza O, Ocaña Fernández MDÁ, Fleischer R, Eravci M, Weise C, Martinac B, Biro M, ... Lewin GR, et al. TMEM87a/Elkin1, a component of a novel mechanoelectrical transduction pathway, modulates melanoma adhesion and migration. Elife. 9. PMID 32228863 DOI: 10.7554/eLife.53308  1
2020 Paricio-Montesinos R, Schwaller F, Udhayachandran A, Rau F, Walcher J, Evangelista R, Vriens J, Voets T, Poulet JFA, Lewin GR. The Sensory Coding of Warm Perception. Neuron. PMID 32208171 DOI: 10.1016/j.neuron.2020.02.035  1
2020 Smith ESJ, Park TJ, Lewin GR. Independent evolution of pain insensitivity in African mole-rats: origins and mechanisms. Journal of Comparative Physiology. a, Neuroethology, Sensory, Neural, and Behavioral Physiology. PMID 32206859 DOI: 10.1007/s00359-020-01414-w  1
2019 Servin-Vences MR, Poole K, Sporbert A, Lewin GR, Margineanu A. Collagen Organization Within the Cartilage of Trpv4 Mice Studied with Two-Photon Microscopy and Polarized Second Harmonic Generation. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. PMID 31603601 DOI: 10.1002/cyto.a.23900  1
2019 Eigenbrod O, Debus KY, Reznick J, Bennett NC, Sánchez-Carranza O, Omerbašić D, Hart DW, Barker AJ, Zhong W, Lutermann H, Katandukila JV, Mgode G, Park TJ, Lewin GR. Rapid molecular evolution of pain insensitivity in multiple African rodents. Science (New York, N.Y.). 364: 852-859. PMID 31147513 DOI: 10.1126/science.aau0236  1
2019 Bozek K, Khrameeva EE, Reznick J, Omerbašić D, Bennett NC, Lewin GR, Azpurua J, Gorbunova V, Seluanov A, Regnard P, Wanert F, Marchal J, Pifferi F, Aujard F, Liu Z, et al. Publisher Correction: Lipidome determinants of maximal lifespan in mammals. Scientific Reports. 9: 6972. PMID 31043659 DOI: 10.1038/s41598-019-43122-9  1
2018 Murthy SE, Loud MC, Daou I, Marshall KL, Schwaller F, Kühnemund J, Francisco AG, Keenan WT, Dubin AE, Lewin GR, Patapoutian A. The mechanosensitive ion channel Piezo2 mediates sensitivity to mechanical pain in mice. Science Translational Medicine. 10. PMID 30305457 DOI: 10.1126/scitranslmed.aat9897  1
2018 Walcher J, Ojeda-Alonso J, Haseleu J, Oosthuizen MK, Rowe AH, Bennett NC, Lewin GR. Specialized mechanoreceptor systems in rodent glabrous skin. The Journal of Physiology. PMID 30132906 DOI: 10.1113/JP276608  1
2018 Kim M, Wende H, Walcher J, Küehnemund J, Cheret C, Kempa S, McShane E, Selbach M, Lewin GR, Birchmeier C. Maf links Neuregulin1 signaling to cholesterol synthesis in myelinating Schwann cells. Genes & Development. PMID 29748249 DOI: 10.1101/gad.310490.117  1
2018 Moroni M, Servin-Vences MR, Fleischer R, Sánchez-Carranza O, Lewin GR. Voltage gating of mechanosensitive PIEZO channels. Nature Communications. 9: 1096. PMID 29545531 DOI: 10.1038/s41467-018-03502-7  1
2018 Tröster P, Haseleu J, Petersen J, Drees O, Schmidtko A, Schwaller F, Lewin GR, Ter-Avetisyan G, Winter Y, Peters S, Feil S, Feil R, Rathjen FG, Schmidt H. The Absence of Sensory Axon Bifurcation Affects Nociception and Termination Fields of Afferents in the Spinal Cord. Frontiers in Molecular Neuroscience. 11: 19. PMID 29472841 DOI: 10.3389/fnmol.2018.00019  1
2018 Dawes JM, Weir GA, Middleton SJ, Patel R, Chisholm KI, Pettingill P, Peck LJ, Sheridan J, Shakir A, Jacobson L, Gutierrez-Mecinas M, Galino J, Walcher J, Kühnemund J, Kuehn H, ... ... Lewin GR, et al. Immune or Genetic-Mediated Disruption of CASPR2 Causes Pain Hypersensitivity Due to Enhanced Primary Afferent Excitability. Neuron. PMID 29429934 DOI: 10.1016/j.neuron.2018.01.033  1
2018 Servin-Vences MR, Richardson J, Lewin GR, Poole K. Mechanoelectrical transduction in chondrocytes. Clinical and Experimental Pharmacology & Physiology. PMID 29359488 DOI: 10.1111/1440-1681.12917  1
2017 Moshourab R, Bégay V, Wetzel C, Walcher J, Middleton S, Gross M, Lewin GR. Congenital deafness is associated with specific somatosensory deficits in adolescents. Scientific Reports. 7: 4251. PMID 28652589 DOI: 10.1038/s41598-017-04074-0  1
2017 Park TJ, Reznick J, Peterson BL, Blass G, Omerbašić D, Bennett NC, Kuich PHJL, Zasada C, Browe BM, Hamann W, Applegate DT, Radke MH, Kosten T, Lutermann H, Gavaghan V, ... ... Lewin GR, et al. Fructose-driven glycolysis supports anoxia resistance in the naked mole-rat. Science (New York, N.Y.). 356: 307-311. PMID 28428423 DOI: 10.1126/science.aab3896  1
2017 Bernal Sierra YA, Haseleu J, Kozlenkov A, Bégay V, Lewin GR. Genetic Tracing of Cav3.2 T-Type Calcium Channel Expression in the Peripheral Nervous System. Frontiers in Molecular Neuroscience. 10: 70. PMID 28360836 DOI: 10.3389/fnmol.2017.00070  1
2017 Rocio Servin-Vences M, Moroni M, Lewin GR, Poole K. Direct measurement of TRPV4 and PIEZO1 activity reveals multiple mechanotransduction pathways in chondrocytes. Elife. 6. PMID 28135189 DOI: 10.7554/eLife.21074  1
2017 Bozek K, Khrameeva EE, Reznick J, Omerbašić D, Bennett NC, Lewin GR, Azpurua J, Gorbunova V, Seluanov A, Regnard P, Wanert F, Marchal J, Pifferi F, Aujard F, Liu Z, et al. Lipidome determinants of maximal lifespan in mammals. Scientific Reports. 7: 5. PMID 28127055 DOI: 10.1038/s41598-017-00037-7  1
2016 Wetzel C, Pifferi S, Picci C, Gök C, Hoffmann D, Bali KK, Lampe A, Lapatsina L, Fleischer R, Smith ES, Bégay V, Moroni M, Estebanez L, Kühnemund J, Walcher J, ... ... Lewin GR, et al. Small-molecule inhibition of STOML3 oligomerization reverses pathological mechanical hypersensitivity. Nature Neuroscience. PMID 27941788 DOI: 10.1038/nn.4454  1
2016 Ventéo S, Laffray S, Wetzel C, Rivat C, Scamps F, Méchaly I, Bauchet L, Raoul C, Bourinet E, Lewin GR, Carroll P, Pattyn A. Fxyd2 regulates Aδ- and C-fiber mechanosensitivity and is required for the maintenance of neuropathic pain. Scientific Reports. 6: 36407. PMID 27805035 DOI: 10.1038/srep36407  1
2016 Omerbašić D, Smith ES, Moroni M, Homfeld J, Eigenbrod O, Bennett NC, Reznick J, Faulkes CG, Selbach M, Lewin GR. Hypofunctional TrkA Accounts for the Absence of Pain Sensitization in the African Naked Mole-Rat. Cell Reports. 17: 748-758. PMID 27732851 DOI: 10.1016/j.celrep.2016.09.035  1
2016 Moshourab R, Frenzel H, Lechner S, Haseleu J, Bégay V, Omerbašić D, Lewin GR. Measurement of Vibration Detection Threshold and Tactile Spatial Acuity in Human Subjects. Journal of Visualized Experiments : Jove. PMID 27684317 DOI: 10.3791/52966  1
2016 Moshourab R, Palada V, Grunwald S, Grieben U, Lewin GR, Spuler S. A Molecular Signature of Myalgia in Myotonic Dystrophy 2. Ebiomedicine. 7: 205-211. PMID 27322473 DOI: 10.1016/j.ebiom.2016.03.017  1
2015 Dezhdar T, Moshourab RA, Fründ I, Lewin GR, Schmuker M. A Probabilistic Model for Estimating the Depth and Threshold Temperature of C-fiber Nociceptors. Scientific Reports. 5: 17670. PMID 26638830 DOI: 10.1038/srep17670  1
2015 Frank JA, Moroni M, Moshourab R, Sumser M, Lewin GR, Trauner D. Photoswitchable fatty acids enable optical control of TRPV1. Nature Communications. 6: 7118. PMID 25997690 DOI: 10.1038/ncomms8118  1
2015 Hanack C, Moroni M, Lima WC, Wende H, Kirchner M, Adelfinger L, Schrenk-Siemens K, Tappe-Theodor A, Wetzel C, Kuich PH, Gassmann M, Roggenkamp D, Bettler B, Lewin GR, Selbach M, et al. GABA blocks pathological but not acute TRPV1 pain signals. Cell. 160: 759-70. PMID 25679765 DOI: 10.1016/j.cell.2015.01.022  1
2015 Omerbaši? D, Schuhmacher LN, Bernal Sierra YA, Smith ES, Lewin GR. ASICs and mammalian mechanoreceptor function. Neuropharmacology. 94: 80-86. PMID 25528740 DOI: 10.1016/j.neuropharm.2014.12.007  1
2015 Schrenk-Siemens K, Wende H, Prato V, Song K, Rostock C, Loewer A, Utikal J, Lewin GR, Lechner SG, Siemens J. PIEZO2 is required for mechanotransduction in human stem cell-derived touch receptors. Nature Neuroscience. 18: 10-6. PMID 25469543 DOI: 10.1038/nn.3894  1
2015 Poole K, Moroni M, Lewin GR. Sensory mechanotransduction at membrane-matrix interfaces. PflüGers Archiv : European Journal of Physiology. 467: 121-32. PMID 24981693 DOI: 10.1007/s00424-014-1563-6  1
2014 Ranade SS, Woo SH, Dubin AE, Moshourab RA, Wetzel C, Petrus M, Mathur J, Bégay V, Coste B, Mainquist J, Wilson AJ, Francisco AG, Reddy K, Qiu Z, Wood JN, ... Lewin GR, et al. Piezo2 is the major transducer of mechanical forces for touch sensation in mice. Nature. 516: 121-5. PMID 25471886 DOI: 10.1038/nature13980  1
2014 Milenkovic N, Zhao WJ, Walcher J, Albert T, Siemens J, Lewin GR, Poulet JF. A somatosensory circuit for cooling perception in mice. Nature Neuroscience. 17: 1560-6. PMID 25262494 DOI: 10.1038/nn.3828  1
2014 Lewin GR, Carter BD. Neurotrophic factors. Preface. Handbook of Experimental Pharmacology. 220: v-vi. PMID 24941498  1
2014 Lewin GR, Lechner SG, Smith ES. Nerve growth factor and nociception: from experimental embryology to new analgesic therapy. Handbook of Experimental Pharmacology. 220: 251-82. PMID 24668476 DOI: 10.1007/978-3-642-45106-5_10  1
2014 Ceko M, Milenkovic N, le Coutre P, Westermann J, Lewin GR. Inhibition of c-Kit signaling is associated with reduced heat and cold pain sensitivity in humans. Pain. 155: 1222-8. PMID 24662807 DOI: 10.1016/j.pain.2014.03.010  1
2014 Poole K, Herget R, Lapatsina L, Ngo HD, Lewin GR. Tuning Piezo ion channels to detect molecular-scale movements relevant for fine touch. Nature Communications. 5: 3520. PMID 24662763 DOI: 10.1038/ncomms4520  1
2014 Lewin GR, Nykjaer A. Pro-neurotrophins, sortilin, and nociception. The European Journal of Neuroscience. 39: 363-74. PMID 24494677 DOI: 10.1111/ejn.12466  1
2014 Sheean ME, McShane E, Cheret C, Walcher J, Müller T, Wulf-Goldenberg A, Hoelper S, Garratt AN, Krüger M, Rajewsky K, Meijer D, Birchmeier W, Lewin GR, Selbach M, Birchmeier C. Activation of MAPK overrides the termination of myelin growth and replaces Nrg1/ErbB3 signals during Schwann cell development and myelination. Genes & Development. 28: 290-303. PMID 24493648 DOI: 10.1101/gad.230045.113  1
2014 Haseleu J, OmerbaÅ¡ić D, Frenzel H, Gross M, Lewin GR. Water-induced finger wrinkles do not affect touch acuity or dexterity in handling wet objects. Plos One. 9: e84949. PMID 24416318 DOI: 10.1371/journal.pone.0084949  1
2014 Kozlenkov A, Lapatsina L, Lewin GR, Smith ES. Subunit-specific inhibition of acid sensing ion channels by stomatin-like protein 1. The Journal of Physiology. 592: 557-69. PMID 24247984 DOI: 10.1113/jphysiol.2013.258657  1
2013 Lewin GR. Evolution. Natural selection and pain meet at a sodium channel. Science (New York, N.Y.). 342: 428-9. PMID 24159033 DOI: 10.1126/science.1244375  1
2013 Moshourab RA, Wetzel C, Martinez-Salgado C, Lewin GR. Stomatin-domain protein interactions with acid-sensing ion channels modulate nociceptor mechanosensitivity. The Journal of Physiology. 591: 5555-74. PMID 23959680 DOI: 10.1113/jphysiol.2013.261180  1
2013 Lechner SG, Lewin GR. Hairy sensation. Physiology (Bethesda, Md.). 28: 142-50. PMID 23636260 DOI: 10.1152/physiol.00059.2012  1
2012 Brand J, Smith ES, Schwefel D, Lapatsina L, Poole K, OmerbaÅ¡ić D, Kozlenkov A, Behlke J, Lewin GR, Daumke O. A stomatin dimer modulates the activity of acid-sensing ion channels. The Embo Journal. 31: 3635-46. PMID 22850675 DOI: 10.1038/emboj.2012.203  1
2012 Stock K, Kumar J, Synowitz M, Petrosino S, Imperatore R, Smith ES, Wend P, Purfürst B, Nuber UA, Gurok U, Matyash V, Wälzlein JH, Chirasani SR, Dittmar G, Cravatt BF, ... ... Lewin GR, et al. Neural precursor cells induce cell death of high-grade astrocytomas through stimulation of TRPV1. Nature Medicine. 18: 1232-8. PMID 22820645 DOI: 10.1038/nm.2827  1
2012 Lapatsina L, Jira JA, Smith ES, Poole K, Kozlenkov A, Bilbao D, Lewin GR, Heppenstall PA. Regulation of ASIC channels by a stomatin/STOML3 complex located in a mobile vesicle pool in sensory neurons. Open Biology. 2: 120096. PMID 22773952 DOI: 10.1098/rsob.120096  1
2012 Frenzel H, Bohlender J, Pinsker K, Wohlleben B, Tank J, Lechner SG, Schiska D, Jaijo T, Rüschendorf F, Saar K, Jordan J, Millán JM, Gross M, Lewin GR. A genetic basis for mechanosensory traits in humans. Plos Biology. 10: e1001318. PMID 22563300 DOI: 10.1371/journal.pbio.1001318  1
2012 St John Smith E, Purfürst B, Grigoryan T, Park TJ, Bennett NC, Lewin GR. Specific paucity of unmyelinated C-fibers in cutaneous peripheral nerves of the African naked-mole rat: comparative analysis using six species of Bathyergidae. The Journal of Comparative Neurology. 520: 2785-803. PMID 22528859 DOI: 10.1002/cne.23133  1
2012 Luo C, Gangadharan V, Bali KK, Xie RG, Agarwal N, Kurejova M, Tappe-Theodor A, Tegeder I, Feil S, Lewin G, Polgar E, Todd AJ, Schlossmann J, Hofmann F, Liu DL, et al. Presynaptically localized cyclic GMP-dependent protein kinase 1 is a key determinant of spinal synaptic potentiation and pain hypersensitivity. Plos Biology. 10: e1001283. PMID 22427743 DOI: 10.1371/journal.pbio.1001283  1
2012 Wende H, Lechner SG, Cheret C, Bourane S, Kolanczyk ME, Pattyn A, Reuter K, Munier FL, Carroll P, Lewin GR, Birchmeier C. The transcription factor c-Maf controls touch receptor development and function. Science (New York, N.Y.). 335: 1373-6. PMID 22345400 DOI: 10.1126/science.1214314  1
2012 Heidenreich M, Lechner SG, Vardanyan V, Wetzel C, Cremers CW, De Leenheer EM, Aránguez G, Moreno-Pelayo MÁ, Jentsch TJ, Lewin GR. KCNQ4 K(+) channels tune mechanoreceptors for normal touch sensation in mouse and man. Nature Neuroscience. 15: 138-45. PMID 22101641 DOI: 10.1038/nn.2985  1
2012 Tappe-Theodor A, Constantin CE, Tegeder I, Lechner SG, Langeslag M, Lepcynzsky P, Wirotanseng RI, Kurejova M, Agarwal N, Nagy G, Todd A, Wettschureck N, Offermanns S, Kress M, Lewin GR, et al. Gα(q/11) signaling tonically modulates nociceptor function and contributes to activity-dependent sensitization. Pain. 153: 184-96. PMID 22071319 DOI: 10.1016/j.pain.2011.10.014  1
2012 Lapatsina L, Brand J, Poole K, Daumke O, Lewin GR. Stomatin-domain proteins. European Journal of Cell Biology. 91: 240-5. PMID 21501885 DOI: 10.1016/j.ejcb.2011.01.018  1
2011 Smith ES, OmerbaÅ¡ić D, Lechner SG, Anirudhan G, Lapatsina L, Lewin GR. The molecular basis of acid insensitivity in the African naked mole-rat. Science (New York, N.Y.). 334: 1557-60. PMID 22174253 DOI: 10.1126/science.1213760  1
2011 Chiang LY, Poole K, Oliveira BE, Duarte N, Sierra YA, Bruckner-Tuderman L, Koch M, Hu J, Lewin GR. Laminin-332 coordinates mechanotransduction and growth cone bifurcation in sensory neurons. Nature Neuroscience. 14: 993-1000. PMID 21725315 DOI: 10.1038/nn.2873  1
2011 Wang R, Lewin GR. The Cav3.2 T-type calcium channel regulates temporal coding in mouse mechanoreceptors. The Journal of Physiology. 589: 2229-43. PMID 21486775 DOI: 10.1113/jphysiol.2010.203463  1
2011 Gangadharan V, Wang R, Ulzhöfer B, Luo C, Bardoni R, Bali KK, Agarwal N, Tegeder I, Hildebrandt U, Nagy GG, Todd AJ, Ghirri A, Häussler A, Sprengel R, Seeburg PH, ... ... Lewin GR, et al. Peripheral calcium-permeable AMPA receptors regulate chronic inflammatory pain in mice. The Journal of Clinical Investigation. 121: 1608-23. PMID 21383497 DOI: 10.1172/JCI44911  1
2011 Lechner SG, Markworth S, Poole K, Smith ES, Lapatsina L, Frahm S, May M, Pischke S, Suzuki M, Ibañez-Tallon I, Luft FC, Jordan J, Lewin GR. The molecular and cellular identity of peripheral osmoreceptors. Neuron. 69: 332-44. PMID 21262470 DOI: 10.1016/j.neuron.2010.12.028  1
2011 Vaegter CB, Jansen P, Fjorback AW, Glerup S, Skeldal S, Kjolby M, Richner M, Erdmann B, Nyengaard JR, Tessarollo L, Lewin GR, Willnow TE, Chao MV, Nykjaer A. Sortilin associates with Trk receptors to enhance anterograde transport and neurotrophin signaling. Nature Neuroscience. 14: 54-61. PMID 21102451 DOI: 10.1038/nn.2689  1
2010 Brand A, Smith ES, Lewin GR, Park TJ. Functional neurokinin and NMDA receptor activity in an animal naturally lacking substance P: the naked mole-rat. Plos One. 5: e15162. PMID 21200438 DOI: 10.1371/journal.pone.0015162  1
2010 Smith ES, Blass GR, Lewin GR, Park TJ. Absence of histamine-induced itch in the African naked mole-rat and "rescue" by Substance P. Molecular Pain. 6: 29. PMID 20497578 DOI: 10.1186/1744-8069-6-29  1
2010 Bishop T, Marchand F, Young AR, Lewin GR, McMahon SB. Ultraviolet-B-induced mechanical hyperalgesia: A role for peripheral sensitisation. Pain. 150: 141-52. PMID 20478657 DOI: 10.1016/j.pain.2010.04.018  1
2010 Stürzebecher AS, Hu J, Smith ES, Frahm S, Santos-Torres J, Kampfrath B, Auer S, Lewin GR, Ibañez-Tallon I. An in vivo tethered toxin approach for the cell-autonomous inactivation of voltage-gated sodium channel currents in nociceptors. The Journal of Physiology. 588: 1695-707. PMID 20308253 DOI: 10.1113/jphysiol.2010.187112  1
2010 Hu J, Chiang LY, Koch M, Lewin GR. Evidence for a protein tether involved in somatic touch. The Embo Journal. 29: 855-67. PMID 20075867 DOI: 10.1038/emboj.2009.398  1
2009 Smith ES, Lewin GR. Nociceptors: a phylogenetic view. Journal of Comparative Physiology. a, Neuroethology, Sensory, Neural, and Behavioral Physiology. 195: 1089-106. PMID 19830434 DOI: 10.1007/s00359-009-0482-z  1
2009 Lechner SG, Lewin GR. Peripheral sensitisation of nociceptors via G-protein-dependent potentiation of mechanotransduction currents. The Journal of Physiology. 587: 3493-503. PMID 19505980 DOI: 10.1113/jphysiol.2009.175059  1
2009 Lechner SG, Frenzel H, Wang R, Lewin GR. Developmental waves of mechanosensitivity acquisition in sensory neuron subtypes during embryonic development. The Embo Journal. 28: 1479-91. PMID 19322198 DOI: 10.1038/emboj.2009.73  1
2008 Milenkovic N, Wetzel C, Moshourab R, Lewin GR. Speed and temperature dependences of mechanotransduction in afferent fibers recorded from the mouse saphenous nerve. Journal of Neurophysiology. 100: 2771-83. PMID 18815344 DOI: 10.1152/jn.90799.2008  1
2008 Lewin GR. Stretching it for pain. Pain. 137: 3-4. PMID 18430517 DOI: 10.1016/j.pain.2008.03.026  1
2008 Park TJ, Lu Y, Jüttner R, Smith ES, Hu J, Brand A, Wetzel C, Milenkovic N, Erdmann B, Heppenstall PA, Laurito CE, Wilson SP, Lewin GR. Selective inflammatory pain insensitivity in the African naked mole-rat (Heterocephalus glaber). Plos Biology. 6: e13. PMID 18232734 DOI: 10.1371/journal.pbio.0060013  1
2007 Milenkovic N, Frahm C, Gassmann M, Griffel C, Erdmann B, Birchmeier C, Lewin GR, Garratt AN. Nociceptive tuning by stem cell factor/c-Kit signaling. Neuron. 56: 893-906. PMID 18054864 DOI: 10.1016/j.neuron.2007.10.040  1
2007 Martinez-Salgado C, Benckendorff AG, Chiang LY, Wang R, Milenkovic N, Wetzel C, Hu J, Stucky CL, Parra MG, Mohandas N, Lewin GR. Stomatin and sensory neuron mechanotransduction. Journal of Neurophysiology. 98: 3802-8. PMID 17942620 DOI: 10.1152/jn.00860.2007  1
2007 Jansen P, Giehl K, Nyengaard JR, Teng K, Lioubinski O, Sjoegaard SS, Breiderhoff T, Gotthardt M, Lin F, Eilers A, Petersen CM, Lewin GR, Hempstead BL, Willnow TE, Nykjaer A. Roles for the pro-neurotrophin receptor sortilin in neuronal development, aging and brain injury. Nature Neuroscience. 10: 1449-57. PMID 17934455 DOI: 10.1038/nn2000  1
2007 Wetzel C, Hu J, Riethmacher D, Benckendorff A, Harder L, Eilers A, Moshourab R, Kozlenkov A, Labuz D, Caspani O, Erdmann B, Machelska H, Heppenstall PA, Lewin GR. A stomatin-domain protein essential for touch sensation in the mouse. Nature. 445: 206-9. PMID 17167420 DOI: 10.1038/nature05394  1
2006 Hu J, Lewin GR. Mechanosensitive currents in the neurites of cultured mouse sensory neurones. The Journal of Physiology. 577: 815-28. PMID 17038434 DOI: 10.1113/jphysiol.2006.117648  1
2006 Heppenstall PA, Lewin GR. A role for T-type Ca2+ channels in mechanosensation. Cell Calcium. 40: 165-74. PMID 16777219 DOI: 10.1016/j.ceca.2006.04.021  1
2006 Hu J, Milenkovic N, Lewin GR. The high threshold mechanotransducer: a status report. Pain. 120: 3-7. PMID 16360277 DOI: 10.1016/j.pain.2005.11.002  1
2006 Bönsch R, Lewin GR. Chapter 13 Finding Sensory Neuron Mechanotransduction Components Current Topics in Membranes. 57: 379-414. DOI: 10.1016/S1063-5823(06)57012-7  1
2005 McIlwrath SL, Hu J, Anirudhan G, Shin JB, Lewin GR. The sensory mechanotransduction ion channel ASIC2 (acid sensitive ion channel 2) is regulated by neurotrophin availability. Neuroscience. 131: 499-511. PMID 15708491 DOI: 10.1016/j.neuroscience.2004.11.030  1
2004 Page AJ, Brierley SM, Martin CM, Martinez-Salgado C, Wemmie JA, Brennan TJ, Symonds E, Omari T, Lewin GR, Welsh MJ, Blackshaw LA. The ion channel ASIC1 contributes to visceral but not cutaneous mechanoreceptor function. Gastroenterology. 127: 1739-47. PMID 15578512 DOI: 10.1053/j.gastro.2004.08.061  1
2004 Hartmann B, Ahmadi S, Heppenstall PA, Lewin GR, Schott C, Borchardt T, Seeburg PH, Zeilhofer HU, Sprengel R, Kuner R. The AMPA receptor subunits GluR-A and GluR-B reciprocally modulate spinal synaptic plasticity and inflammatory pain. Neuron. 44: 637-50. PMID 15541312 DOI: 10.1016/j.neuron.2004.10.029  1
2004 Dubreuil AS, Boukhaddaoui H, Desmadryl G, Martinez-Salgado C, Moshourab R, Lewin GR, Carroll P, Valmier J, Scamps F. Role of T-type calcium current in identified D-hair mechanoreceptor neurons studied in vitro. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8480-4. PMID 15456821 DOI: 10.1523/JNEUROSCI.1598-04.2004  1
2004 Lewin GR, Moshourab R. Mechanosensation and pain. Journal of Neurobiology. 61: 30-44. PMID 15362151 DOI: 10.1002/neu.20078  1
2004 Lewin GR, Lu Y, Park TJ. A plethora of painful molecules. Current Opinion in Neurobiology. 14: 443-9. PMID 15321065 DOI: 10.1016/j.conb.2004.07.009  1
2003 Lucius H, Friedrichson T, Kurzchalia TV, Lewin GR. Identification of caveolae-like structures on the surface of intact cells using scanning force microscopy. The Journal of Membrane Biology. 194: 97-108. PMID 14502434 DOI: 10.1007/s00232-003-2029-5  1
2003 Shin JB, Martinez-Salgado C, Heppenstall PA, Lewin GR. A T-type calcium channel required for normal function of a mammalian mechanoreceptor. Nature Neuroscience. 6: 724-30. PMID 12808460 DOI: 10.1038/nn1076  1
2002 Stucky CL, Rossi J, Airaksinen MS, Lewin GR. GFR alpha2/neurturin signalling regulates noxious heat transduction in isolectin B4-binding mouse sensory neurons. The Journal of Physiology. 545: 43-50. PMID 12433948 DOI: 10.1113/jphysiol.2002.027656  1
2002 Schmidt H, Werner M, Heppenstall PA, Henning M, Moré MI, Kühbandner S, Lewin GR, Hofmann F, Feil R, Rathjen FG. cGMP-mediated signaling via cGKIalpha is required for the guidance and connectivity of sensory axons. The Journal of Cell Biology. 159: 489-98. PMID 12417579 DOI: 10.1083/jcb.200207058  1
2002 Stucky CL, Shin JB, Lewin GR. Neurotrophin-4: a survival factor for adult sensory neurons. Current Biology : Cb. 12: 1401-4. PMID 12194821 DOI: 10.1016/S0960-9822(02)01072-2  1
2002 Müller T, Brohmann H, Pierani A, Heppenstall PA, Lewin GR, Jessell TM, Birchmeier C. The homeodomain factor lbx1 distinguishes two major programs of neuronal differentiation in the dorsal spinal cord. Neuron. 34: 551-62. PMID 12062039 DOI: 10.1016/S0896-6273(02)00689-X  1
2002 Postigo A, Calella AM, Fritzsch B, Knipper M, Katz D, Eilers A, Schimmang T, Lewin GR, Klein R, Minichiello L. Distinct requirements for TrkB and TrkC signaling in target innervation by sensory neurons. Genes & Development. 16: 633-45. PMID 11877382 DOI: 10.1101/gad.217902  1
2001 Price MP, McIlwrath SL, Xie J, Cheng C, Qiao J, Tarr DE, Sluka KA, Brennan TJ, Lewin GR, Welsh MJ. The DRASIC cation channel contributes to the detection of cutaneous touch and acid stimuli in mice. Neuron. 32: 1071-83. PMID 11754838 DOI: 10.1016/S0896-6273(01)00547-5  1
2001 Hamilton SG, McMahon SB, Lewin GR. Selective activation of nociceptors by P2X receptor agonists in normal and inflamed rat skin. The Journal of Physiology. 534: 437-45. PMID 11454962 DOI: 10.1111/j.1469-7793.2001.00437.x  1
2001 Heppenstall PA, Lewin GR. BDNF but not NT-4 is required for normal flexion reflex plasticity and function. Proceedings of the National Academy of Sciences of the United States of America. 98: 8107-12. PMID 11438749 DOI: 10.1073/pnas.141015098  1
2001 Roosen A, Schober A, Strelau J, Bottner M, Faulhaber J, Bendner G, McIlwrath SL, Seller H, Ehmke H, Lewin GR, Unsicker K. Lack of neurotrophin-4 causes selective structural and chemical deficits in sympathetic ganglia and their preganglionic innervation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 3073-84. PMID 11312292  1
2000 Heppenstall PA, Lewin GR. Neurotrophins, nociceptors and pain. Current Opinion in Anaesthesiology. 13: 573-6. PMID 17016360 DOI: 10.1097/00001503-200010000-00015  1
2000 Price MP, Lewin GR, McIlwrath SL, Cheng C, Xie J, Heppenstall PA, Stucky CL, Mannsfeldt AG, Brennan TJ, Drummond HA, Qiao J, Benson CJ, Tarr DE, Hrstka RF, Yang B, et al. The mammalian sodium channel BNC1 is required for normal touch sensation. Nature. 407: 1007-11. PMID 11069180 DOI: 10.1038/35039512  1
2000 Pesquero JB, Araujo RC, Heppenstall PA, Stucky CL, Silva JA, Walther T, Oliveira SM, Pesquero JL, Paiva AC, Calixto JB, Lewin GR, Bader M. Hypoalgesia and altered inflammatory responses in mice lacking kinin B1 receptors. Proceedings of the National Academy of Sciences of the United States of America. 97: 8140-5. PMID 10859349 DOI: 10.1073/pnas.120035997  1
1999 Lommatzsch M, Braun A, Mannsfeldt A, Botchkarev VA, Botchkareva NV, Paus R, Fischer A, Lewin GR, Renz H. Abundant production of brain-derived neurotrophic factor by adult visceral epithelia. Implications for paracrine and target-derived Neurotrophic functions. The American Journal of Pathology. 155: 1183-93. PMID 10514401 DOI: 10.1016/S0002-9440(10)65221-2  1
1999 Braun A, Lommatzsch M, Mannsfeldt A, Neuhaus-Steinmetz U, Fischer A, Schnoy N, Lewin GR, Renz H. Cellular sources of enhanced brain-derived neurotrophic factor production in a mouse model of allergic inflammation. American Journal of Respiratory Cell and Molecular Biology. 21: 537-46. PMID 10502564 DOI: 10.1165/ajrcmb.21.4.3670  1
1999 Stucky CL, Lewin GR. Isolectin B(4)-positive and -negative nociceptors are functionally distinct. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6497-505. PMID 10414978  1
1999 Mannsfeldt AG, Carroll P, Stucky CL, Lewin GR. Stomatin, a MEC-2 like protein, is expressed by mammalian sensory neurons. Molecular and Cellular Neurosciences. 13: 391-404. PMID 10383825 DOI: 10.1006/mcne.1999.0761  1
1999 Braun A, Lommatzsch M, Lewin GR, Virchow JC, Renz H. Neurotrophins: a link between airway inflammation and airway smooth muscle contractility in asthma? International Archives of Allergy and Immunology. 118: 163-5. PMID 10224367  1
1999 Belyantseva IA, Lewin GR. Stability and plasticity of primary afferent projections following nerve regeneration and central degeneration. The European Journal of Neuroscience. 11: 457-68. PMID 10051747 DOI: 10.1046/j.1460-9568.1999.00458.x  0.6
1999 Botchkarev VA, Botchkareva NV, Welker P, Metz M, Lewin GR, Subramaniam A, Bulfone-Paus S, Hagen E, Braun A, Lommatzsch M, Renz H, Paus AR. A new role for neurotrophins: involvement of brain-derived neurotrophic factor and neurotrophin-4 in hair cycle control. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 13: 395-410. PMID 9973328  1
1998 Carroll P, Lewin GR, Koltzenburg M, Toyka KV, Thoenen H. A role for BDNF in mechanosensation. Nature Neuroscience. 1: 42-6. PMID 10195107 DOI: 10.1038/242  1
1998 Botchkarev VA, Botchkareva NV, Lommatzsch M, Peters EM, Lewin GR, Subramaniam A, Braun A, Renz H, Paus R. BDNF overexpression induces differential increases among subsets of sympathetic innervation in murine back skin. The European Journal of Neuroscience. 10: 3276-83. PMID 9786221 DOI: 10.1046/j.1460-9568.1998.00365.x  1
1998 Schober A, Wolf N, Huber K, Hertel R, Krieglstein K, Minichiello L, Kahane N, Widenfalk J, Kalcheim C, Olson L, Klein R, Lewin GR, Unsicker K. TrkB and neurotrophin-4 are important for development and maintenance of sympathetic preganglionic neurons innervating the adrenal medulla. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 7272-84. PMID 9736648  1
1998 Botchkarev VA, Welker P, Albers KM, Botchkareva NV, Metz M, Lewin GR, Bulfone-Paus S, Peters EM, Lindner G, Paus R. A new role for neurotrophin-3: involvement in the regulation of hair follicle regression (catagen). The American Journal of Pathology. 153: 785-99. PMID 9736028 DOI: 10.1016/S0002-9440(10)65621-0  1
1998 Minichiello L, Casagranda F, Tatche RS, Stucky CL, Postigo A, Lewin GR, Davies AM, Klein R. Point mutation in trkB causes loss of NT4-dependent neurons without major effects on diverse BDNF responses. Neuron. 21: 335-45. PMID 9728915  1
1998 Botchkarev VA, Botchkarev NV, Albers KM, van der Veen C, Lewin GR, Paus R. Neurotrophin-3 involvement in the regulation of hair follicle morphogenesis. The Journal of Investigative Dermatology. 111: 279-85. PMID 9699730 DOI: 10.1046/j.1523-1747.1998.00277.x  1
1997 Koltzenburg M, Lewin GR. Receptive properties of embryonic chick sensory neurons innervating skin. Journal of Neurophysiology. 78: 2560-8. PMID 9356405  1
1997 Riethmacher D, Sonnenberg-Riethmacher E, Brinkmann V, Yamaai T, Lewin GR, Birchmeier C. Severe neuropathies in mice with targeted mutations in the ErbB3 receptor. Nature. 389: 725-30. PMID 9338783 DOI: 10.1038/39593  1
1997 Koltzenburg M, Stucky CL, Lewin GR. Receptive properties of mouse sensory neurons innervating hairy skin. Journal of Neurophysiology. 78: 1841-50. PMID 9325353  1
1996 Lewin GR, Mendell LM. Maintenance of modality-specific connections in the spinal cord after neonatal nerve growth factor deprivation. The European Journal of Neuroscience. 8: 1677-84. PMID 8921258  1
1996 Lewin GR, Barde YA. Physiology of the neurotrophins. Annual Review of Neuroscience. 19: 289-317. PMID 8833445 DOI: 10.1146/  1
1996 Airaksinen MS, Koltzenburg M, Lewin GR, Masu Y, Helbig C, Wolf E, Brem G, Toyka KV, Thoenen H, Meyer M. Specific subtypes of cutaneous mechanoreceptors require neurotrophin-3 following peripheral target innervation. Neuron. 16: 287-95. PMID 8789944 DOI: 10.1016/S0896-6273(00)80047-1  1
1996 Lewin GR. Neurotrophins and the specification of neuronal phenotype. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 351: 405-11. PMID 8730778 DOI: 10.1098/rstb.1996.0035  1
1996 Ockel M, von Schack D, Schröpel A, Dechant G, Lewin GR, Barde YA. Roles of neurotrophin-3 during early development of the peripheral nervous system. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 351: 383-7. PMID 8730775 DOI: 10.1098/rstb.1996.0032  0.92
1996 Ockel M, Lewin GR, Barde YA. In vivo effects of neurotrophin-3 during sensory neurogenesis. Development (Cambridge, England). 122: 301-7. PMID 8565842  1
1995 Lewin GR. Neurotrophic factors and pain Seminars in the Neurosciences. 7: 227-232. DOI: 10.1006/smns.1995.0026  1
1994 Lewin GR, Mckintosh E, McMahon SB. NMDA receptors and activity-dependent tuning of the receptive fields of spinal cord neurons. Nature. 369: 482-5. PMID 8202138 DOI: 10.1038/369482a0  1
1994 Lewin GR, Mendell LM. Regulation of cutaneous C-fiber heat nociceptors by nerve growth factor in the developing rat. Journal of Neurophysiology. 71: 941-9. PMID 8201434  1
1994 Pierce JP, Lewin GR. An ultrastructural size principle. Neuroscience. 58: 441-6. PMID 8170532 DOI: 10.1016/0306-4522(94)90071-X  1
1994 Lewin GR, Rueff A, Mendell LM. Peripheral and central mechanisms of NGF-induced hyperalgesia. The European Journal of Neuroscience. 6: 1903-12. PMID 7704300 DOI: 10.1111/j.1460-9568.1994.tb00581.x  1
1993 Lewin GR, Ritter AM, Mendell LM. Nerve growth factor-induced hyperalgesia in the neonatal and adult rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 2136-48. PMID 8478693  1
1993 Ritter AM, Lewin GR, Mendell LM. Regulation of myelinated nociceptor function by nerve growth factor in neonatal and adult rats. Brain Research Bulletin. 30: 245-9. PMID 8457872 DOI: 10.1016/0361-9230(93)90251-6  1
1993 Lewin GR, McMahon SB. Muscle afferents innervating skin form somatotopically appropriate connections in the adult rat dorsal horn. The European Journal of Neuroscience. 5: 1083-92. PMID 8281312  1
1993 McMahon SB, Lewin GR, Wall PD. Central hyperexcitability triggered by noxious inputs. Current Opinion in Neurobiology. 3: 602-10. PMID 8219728 DOI: 10.1016/0959-4388(93)90062-4  1
1993 Lewin GR, Mendell LM. Nerve growth factor and nociception. Trends in Neurosciences. 16: 353-9. PMID 7694405 DOI: 10.1016/0166-2236(93)90092-Z  1
1993 Davis BM, Lewin GR, Mendell LM, Jones ME, Albers KM. Altered expression of nerve growth factor in the skin of transgenic mice leads to changes in response to mechanical stimuli. Neuroscience. 56: 789-92. PMID 7506820 DOI: 10.1016/0306-4522(93)90127-2  1
1992 Mendell LM, Lewin GR. Removing constraints on neural sprouting. Current Biology : Cb. 2: 259-61. PMID 15335963 DOI: 10.1016/0960-9822(92)90378-N  1
1992 Lewin GR, Lisney SJ, Mendell LM. Neonatal Anti-NGF Treatment Reduces the Adelta- and C-Fibre Evoked Vasodilator Responses in Rat Skin: Evidence That Nociceptor Afferents Mediate Antidromic Vasodilatation. The European Journal of Neuroscience. 4: 1213-8. PMID 12106384  1
1992 Lewin GR, Winter J, McMahon SB. Regulation of afferent connectivity in the adult spinal cord by nerve growth factor. The European Journal of Neuroscience. 4: 700-7. PMID 12106314  1
1992 Lewin GR, Ritter AM, Mendell LM. On the role of nerve growth factor in the development of myelinated nociceptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 1896-905. PMID 1578276  1
1992 Lewin GR, Lisney SJW, Mendell LM. Neonatal anti-NGF treatment reduces the Aδ- and C-fibre evoked vasodilator responses in rat skin: Evidence that nociceptor afferents mediate antidromic vasodilatation European Journal of Neuroscience. 4: 1213-1218. DOI: 10.1111/j.1460-9568.1992.tb00146.x  1
1991 Lewin GR, McMahon SB. Dorsal Horn Plasticity Following Re-routeing of Peripheral Nerves: Evidence for Tissue-Specific Neurotrophic Influences from the Periphery. The European Journal of Neuroscience. 3: 1112-22. PMID 12106241 DOI: 10.1111/j.1460-9568.1991.tb00046.x  1
1991 McMahon SB, Lewin G, Bloom SR. The consequences of long-term topical capsaicin application in the rat. Pain. 44: 301-10. PMID 2052400 DOI: 10.1016/0304-3959(91)90101-3  0.36
1991 Ritter AM, Lewin GR, Kremer NE, Mendell LM. Requirement for nerve growth factor in the development of myelinated nociceptors in vivo. Nature. 350: 500-2. PMID 2014050 DOI: 10.1038/350500a0  1
1991 Lewin GR, McMahon SB. Physiological properties of primary sensory neurons appropriately and inappropriately innervating skeletal muscle in adult rats. Journal of Neurophysiology. 66: 1218-31. PMID 1761981  1
1991 Lewin GR, McMahon SB. Physiological properties of primary sensory neurons appropriately and inappropriately innervating skin in the adult rat. Journal of Neurophysiology. 66: 1205-17. PMID 1761980  1
1990 Koltzenburg M, Lewin G, McMahon S. Increase of blood flow in skin and spinal cord following activation of small diameter primary afferents. Brain Research. 509: 145-9. PMID 2407316 DOI: 10.1016/0006-8993(90)90322-3  1
1990 Lewin GR, Winter J, McMahon SB. Regulation of afferent connectivity by nerve growth factor in the adult rat spinal cord Journal of Physiology. 430: 113P.  1
1989 McMahon SB, Lewin GR, Anand P, Ghatei MA, Bloom SR. Quantitative analysis of peptide levels and neurogenic extravasation following regeneration of afferents to appropriate and inappropriate targets. Neuroscience. 33: 67-73. PMID 2481246 DOI: 10.1016/0306-4522(89)90311-4  1
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