Christoph Fahlke - Publications

Affiliations: 
Hannover Medical School, Hannover, Niedersachsen, Germany 
Area:
Neurophysiology

120 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Guzman RE, Sierra-Marquez J, Bungert-Plümke S, Franzen A, Fahlke C. Functional Characterization of Variants Associated With X-Linked Intellectual Disability and Epilepsy. Frontiers in Molecular Neuroscience. 15: 872407. PMID 35721313 DOI: 10.3389/fnmol.2022.872407  0.332
2022 Kovermann P, Engels M, Müller F, Fahlke C. Cellular Physiology and Pathophysiology of EAAT Anion Channels. Frontiers in Cellular Neuroscience. 15: 815279. PMID 35087380 DOI: 10.3389/fncel.2021.815279  0.509
2021 Kovermann P, Kolobkova Y, Franzen A, Fahlke C. Mutations associated with epileptic encephalopathy modify EAAT2 anion channel function. Epilepsia. PMID 34961934 DOI: 10.1111/epi.17154  0.446
2021 Gehlen J, Aretzweiler C, Mataruga A, Fahlke C, Müller F. Excitatory amino acid transporter EAAT5 improves temporal resolution in the retina. Eneuro. PMID 34772693 DOI: 10.1523/ENEURO.0406-21.2021  0.358
2021 Engels M, Kalia M, Rahmati S, Petersilie L, Kovermann P, van Putten MJAM, Rose CR, Meijer HGE, Gensch T, Fahlke C. Glial Chloride Homeostasis Under Transient Ischemic Stress. Frontiers in Cellular Neuroscience. 15: 735300. PMID 34602981 DOI: 10.3389/fncel.2021.735300  0.332
2021 Alleva C, Machtens JP, Kortzak D, Weyand I, Fahlke C. Molecular Basis of Coupled Transport and Anion Conduction in Excitatory Amino Acid Transporters. Neurochemical Research. PMID 33587237 DOI: 10.1007/s11064-021-03252-x  0.423
2020 Alleva C, Kovalev K, Astashkin R, Berndt MI, Baeken C, Balandin T, Gordeliy V, Fahlke C, Machtens JP. Na-dependent gate dynamics and electrostatic attraction ensure substrate coupling in glutamate transporters. Science Advances. 6. PMID 33208356 DOI: 10.1126/sciadv.aba9854  0.323
2020 Kovermann P, Untiet V, Kolobkova Y, Engels M, Baader S, Schilling K, Fahlke C. Increased glutamate transporter-associated anion currents cause glial apoptosis in episodic ataxia 6. Brain Communications. 2: fcaa022. PMID 32954283 DOI: 10.1093/braincomms/fcaa022  0.469
2020 Kolen B, Kortzak D, Franzen A, Fahlke C. An amino-terminal point mutation increases EAAT2 anion currents without affecting glutamate transport rates. The Journal of Biological Chemistry. PMID 32820048 DOI: 10.1074/Jbc.Ra120.013704  0.574
2020 Chivukula AS, Suslova M, Kortzak D, Kovermann P, Fahlke C. Functional consequences of SLC1A3 mutations associated with episodic ataxia 6. Human Mutation. PMID 32741053 DOI: 10.1002/Humu.24089  0.444
2020 Grieschat M, Guzman RE, Langschwager K, Fahlke C, Alekov AK. Metabolic energy sensing by mammalian CLC anion/proton exchangers. Embo Reports. e47872. PMID 32390228 DOI: 10.15252/Embr.201947872  0.426
2020 Chiariello MG, Bolnykh V, Ippoliti E, Meloni S, Olsen JMH, Beck T, Rothlisberger U, Fahlke C, Carloni P. Molecular Basis of CLC Antiporter Inhibition by Fluoride. Journal of the American Chemical Society. PMID 32233472 DOI: 10.1021/Jacs.9B13588  0.406
2019 Schewe J, Seidel E, Forslund S, Marko L, Peters J, Muller DN, Fahlke C, Stölting G, Scholl U. Elevated aldosterone and blood pressure in a mouse model of familial hyperaldosteronism with ClC-2 mutation. Nature Communications. 10: 5155. PMID 31727896 DOI: 10.1038/S41467-019-13033-4  0.306
2019 Bratanov D, Kovalev K, Machtens JP, Astashkin R, Chizhov I, Soloviov D, Volkov D, Polovinkin V, Zabelskii D, Mager T, Gushchin I, Rokitskaya T, Antonenko Y, Alekseev A, Shevchenko V, ... ... Fahlke C, et al. Unique structure and function of viral rhodopsins. Nature Communications. 10: 4939. PMID 31666521 DOI: 10.1038/S41467-019-12718-0  0.352
2019 Meyer J, Untiet V, Fahlke C, Gensch T, Rose CR. Quantitative determination of cellular [Na] by fluorescence lifetime imaging with CoroNaGreen. The Journal of General Physiology. PMID 31597684 DOI: 10.1085/Jgp.201912404  0.316
2019 Kortzak D, Alleva C, Weyand I, Ewers D, Zimmermann MI, Franzen A, Machtens JP, Fahlke C. Allosteric gate modulation confers K coupling in glutamate transporters. The Embo Journal. e101468. PMID 31506973 DOI: 10.15252/Embj.2019101468  0.474
2019 Viennet T, Bungert-Plümke S, Elter S, Viegas A, Fahlke C, Etzkorn M. Reconstitution and NMR Characterization of the Ion-Channel Accessory Subunit Barttin in Detergents and Lipid-Bilayer Nanodiscs. Frontiers in Molecular Biosciences. 6: 13. PMID 30931313 DOI: 10.3389/Fmolb.2019.00013  0.403
2018 Wojciechowski D, Kovalchuk E, Yu L, Tan H, Fahlke C, Stölting G, Alekov AK. Barttin Regulates the Subcellular Localization and Posttranslational Modification of Human Cl/H Antiporter ClC-5. Frontiers in Physiology. 9: 1490. PMID 30405442 DOI: 10.3389/Fphys.2018.01490  0.411
2018 Guzman RE, Fahlke C. ClC-3: biophysical properties clarify cellular functions. The Journal of Physiology. PMID 29974478 DOI: 10.1113/Jp276670  0.365
2018 Scholl UI, Stölting G, Schewe J, Thiel A, Tan H, Nelson-Williams C, Vichot AA, Jin SC, Loring E, Untiet V, Yoo T, Choi J, Xu S, Wu A, Kirchner M, ... ... Fahlke C, et al. CLCN2 chloride channel mutations in familial hyperaldosteronism type II. Nature Genetics. PMID 29403011 DOI: 10.1038/S41588-018-0048-5  0.409
2017 Martineau M, Guzman RE, Fahlke C, Klingauf J. VGLUT1 functions as a glutamate/proton exchanger with chloride channel activity in hippocampal glutamatergic synapses. Nature Communications. 8: 2279. PMID 29273736 DOI: 10.1038/S41467-017-02367-6  0.513
2017 Kovermann P, Hessel M, Kortzak D, Jen JC, Koch J, Fahlke C, Freilinger T. Impaired K(+) binding to glial glutamate transporter EAAT1 in migraine. Scientific Reports. 7: 13913. PMID 29066757 DOI: 10.1038/S41598-017-14176-4  0.49
2017 Guzman RE, Bungert-Plümke S, Franzen A, Fahlke C. Preferential Association with ClC-3 Permits Sorting of ClC-4 into Endosomal Compartments. The Journal of Biological Chemistry. PMID 28972156 DOI: 10.1074/Jbc.M117.801951  0.366
2017 Tan H, Bungert-Plümke S, Fahlke C, Stölting G. Reduced Membrane Insertion of CLC-K by V33L Barttin Results in Loss of Hearing, but Leaves Kidney Function Intact. Frontiers in Physiology. 8: 269. PMID 28555110 DOI: 10.3389/Fphys.2017.00269  0.398
2017 Machtens JP, Briones R, Alleva C, de Groot BL, Fahlke C. Gating Charge Calculations by Computational Electrophysiology Simulations. Biophysical Journal. 112: 1396-1405. PMID 28402882 DOI: 10.1016/J.Bpj.2017.02.016  0.417
2016 Rose CR, Ziemens D, Untiet V, Fahlke C. Molecular and cellular physiology of sodium-dependent glutamate transporters. Brain Research Bulletin. PMID 28040508 DOI: 10.1016/J.Brainresbull.2016.12.013  0.497
2016 Untiet V, Kovermann P, Gerkau NJ, Gensch T, Rose CR, Fahlke C. Glutamate transporter-associated anion channels adjust intracellular chloride concentrations during glial maturation. Glia. PMID 27859594 DOI: 10.1002/Glia.23098  0.527
2016 Stölting G, Fahlke C. Chloride channels in renal salt and water transport. Acta Physiologica (Oxford, England). PMID 27636562 DOI: 10.1111/Apha.12802  0.359
2016 Fahlke C, Nilius B. Molecular physiology of anion channels: dual function proteins and new structural motifs-a special issue. Pflugers Archiv : European Journal of Physiology. PMID 26769337 DOI: 10.1007/S00424-016-1791-Z  0.369
2016 Schmalzing G, Detro-Dassen S, Fahlke C, Markwardt F. Oligomerization States of LRRC8A and LRRC8B, Essential Components of the Volume-Regulated Anion Channel VRAC Biophysical Journal. 110: 119a-120a. DOI: 10.1016/J.Bpj.2015.11.695  0.315
2016 Machtens J, Briones R, de Groot BL, Fahlke C. Gating Charge Calculations: Probing Voltage-Sensing Proteins through Computational Electrophysiology Biophysical Journal. 110: 106a. DOI: 10.1016/J.Bpj.2015.11.628  0.358
2015 Fahlke C, Kortzak D, Machtens JP. Molecular physiology of EAAT anion channels. Pflugers Archiv : European Journal of Physiology. PMID 26687113 DOI: 10.1007/S00424-015-1768-3  0.553
2015 Ronstedt K, Sternberg D, Detro-Dassen S, Gramkow T, Begemann B, Becher T, Kilian P, Grieschat M, Machtens JP, Schmalzing G, Fischer M, Fahlke C. Impaired surface membrane insertion of homo- and heterodimeric human muscle chloride channels carrying amino-terminal myotonia-causing mutations. Scientific Reports. 5: 15382. PMID 26502825 DOI: 10.1038/Srep15382  0.445
2015 Silverstein N, Ewers D, Forrest LR, Fahlke C, Kanner BI. Molecular Determinants of Substrate Specificity in Sodium-Coupled Glutamate Transporters. The Journal of Biological Chemistry. PMID 26475859 DOI: 10.1074/Jbc.M115.682666  0.483
2015 Stölting G, Bungert-Plümke S, Franzen A, Fahlke C. Carboxy-terminal Truncations of ClC-Kb Abolish Channel Activation by Barttin Via Modified Common Gating and Trafficking. The Journal of Biological Chemistry. PMID 26453302 DOI: 10.1074/Jbc.M115.675827  0.448
2015 Guzman RE, Miranda-Laferte E, Franzen A, Fahlke C. Neuronal ClC-3 Splice Variants Differ in Subcellular Localizations, but Mediate Identical Transport Functions. The Journal of Biological Chemistry. 290: 25851-62. PMID 26342074 DOI: 10.1074/Jbc.M115.668186  0.392
2015 Wojciechowski D, Fischer M, Fahlke C. Tryptophan Scanning Mutagenesis Identifies the Molecular Determinants of Distinct Barttin Functions. The Journal of Biological Chemistry. 290: 18732-43. PMID 26063802 DOI: 10.1074/Jbc.M114.625376  0.417
2015 Steinke KV, Gorinski N, Wojciechowski D, Todorov V, Guseva D, Ponimaskin E, Fahlke C, Fischer M. Human CLC-K Channels Require Palmitoylation of Their Accessory Subunit Barttin to Be Functional. The Journal of Biological Chemistry. 290: 17390-400. PMID 26013830 DOI: 10.1074/Jbc.M114.631705  0.425
2015 Scholl UI, Stölting G, Nelson-Williams C, Vichot AA, Choi M, Loring E, Prasad ML, Goh G, Carling T, Juhlin CC, Quack I, Rump LC, Thiel A, Lande M, Frazier BG, ... ... Fahlke C, et al. Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism. Elife. 4: e06315. PMID 25907736 DOI: 10.7554/Elife.06315  0.354
2015 Machtens JP, Kortzak D, Lansche C, Leinenweber A, Kilian P, Begemann B, Zachariae U, Ewers D, de Groot BL, Briones R, Fahlke C. Mechanisms of anion conduction by coupled glutamate transporters. Cell. 160: 542-53. PMID 25635461 DOI: 10.1016/J.Cell.2014.12.035  0.567
2015 Jensen AA, Fahlke C, Bjørn-Yoshimoto WE, Bunch L. Excitatory amino acid transporters: recent insights into molecular mechanisms, novel modes of modulation and new therapeutic possibilities. Current Opinion in Pharmacology. 20: 116-23. PMID 25466154 DOI: 10.1016/J.Coph.2014.10.008  0.448
2015 Scholl UI, Stölting G, Nelson-Williams C, Vichot AA, Choi M, Loring E, Prasad ML, Goh G, Carling T, Juhlin CC, Quack I, Rump LC, Thiel A, Lande M, Frazier BG, ... ... Fahlke C, et al. Author response: Recurrent gain of function mutation in calcium channel CACNA1H causes early-onset hypertension with primary aldosteronism Elife. DOI: 10.7554/Elife.06315.019  0.328
2015 Machtens J, Grieschat M, Fahlke C, Alekov AK. Molecular Basis of Voltage-Dependent Gating in ClC Transporters Biophysical Journal. 108: 428a. DOI: 10.1016/J.Bpj.2014.11.2340  0.446
2014 Stölting G, Fischer M, Fahlke C. CLC channel function and dysfunction in health and disease. Frontiers in Physiology. 5: 378. PMID 25339907 DOI: 10.3389/Fphys.2014.00378  0.485
2014 Fahlke C. Behind the scenes of CLC gating: deriving the voltage dependence of membrane proteins by admittance measurements. Biophysical Journal. 107: 1261-2. PMID 25229133 DOI: 10.1016/J.Bpj.2014.08.002  0.525
2014 Guzman RE, Alekov AK, Filippov M, Hegermann J, Fahlke C. Involvement of ClC-3 chloride/proton exchangers in controlling glutamatergic synaptic strength in cultured hippocampal neurons. Frontiers in Cellular Neuroscience. 8: 143. PMID 24904288 DOI: 10.3389/Fncel.2014.00143  0.38
2014 Stölting G, Fischer M, Fahlke C. ClC-1 and ClC-2 form hetero-dimeric channels with novel protopore functions. PflüGers Archiv : European Journal of Physiology. 466: 2191-204. PMID 24638271 DOI: 10.1007/S00424-014-1490-6  0.443
2014 Kegler K, Imbschweiler I, Ulrich R, Kovermann P, Fahlke C, Deschl U, Kalkuhl A, Baumgärnter W, Wewetzer K. CNS Schwann cells display oligodendrocyte precursor-like potassium channel activation and antigenic expression in vitro. Journal of Neural Transmission (Vienna, Austria : 1996). 121: 569-81. PMID 24487976 DOI: 10.1007/S00702-014-1163-9  0.375
2014 Schneider N, Cordeiro S, Machtens JP, Braams S, Rauen T, Fahlke C. Functional properties of the retinal glutamate transporters GLT-1c and EAAT5. The Journal of Biological Chemistry. 289: 1815-24. PMID 24307171 DOI: 10.1074/Jbc.M113.517177  0.564
2014 Machtens J, Lansche C, Leinenweber A, Kilian P, Begemann B, Zachariae U, Ewers D, de Groot BL, Briones R, Fahlke C. Anion Permeation through Excitatory Amino Acid Transporters Biophysical Journal. 106: 149a. DOI: 10.1016/J.Bpj.2013.11.858  0.569
2014 Guzman Castro RE, Miranda Laferte E, Stölting G, Fahlke C. The Amino Terminus Controls Sorting and Voltage Dependence of CLC 3 Biophysical Journal. 106: 146a. DOI: 10.1016/J.Bpj.2013.11.845  0.39
2013 Hotzy J, Schneider N, Kovermann P, Fahlke C. Mutating a conserved proline residue within the trimerization domain modifies Na+ binding to excitatory amino acid transporters and associated conformational changes. The Journal of Biological Chemistry. 288: 36492-501. PMID 24214974 DOI: 10.1074/Jbc.M113.489385  0.537
2013 Scholl UI, Goh G, Stölting G, de Oliveira RC, Choi M, Overton JD, Fonseca AL, Korah R, Starker LF, Kunstman JW, Prasad ML, Hartung EA, Mauras N, Benson MR, Brady T, ... ... Fahlke C, et al. Somatic and germline CACNA1D calcium channel mutations in aldosterone-producing adenomas and primary aldosteronism. Nature Genetics. 45: 1050-4. PMID 23913001 DOI: 10.1038/Ng.2695  0.398
2013 Ewers D, Becher T, Machtens JP, Weyand I, Fahlke C. Induced fit substrate binding to an archeal glutamate transporter homologue. Proceedings of the National Academy of Sciences of the United States of America. 110: 12486-91. PMID 23840066 DOI: 10.1073/Pnas.1300772110  0.415
2013 Stölting G, Teodorescu G, Begemann B, Schubert J, Nabbout R, Toliat MR, Sander T, Nürnberg P, Lerche H, Fahlke C. Regulation of ClC-2 gating by intracellular ATP. Pflã¼Gers Archiv : European Journal of Physiology. 465: 1423-37. PMID 23632988 DOI: 10.1007/S00424-013-1286-0  0.438
2013 Guzman RE, Grieschat M, Fahlke C, Alekov AK. ClC-3 is an intracellular chloride/proton exchanger with large voltage-dependent nonlinear capacitance. Acs Chemical Neuroscience. 4: 994-1003. PMID 23509947 DOI: 10.1021/Cn400032Z  0.447
2013 Abrahamsen B, Schneider N, Erichsen MN, Huynh TH, Fahlke C, Bunch L, Jensen AA. Allosteric modulation of an excitatory amino acid transporter: the subtype-selective inhibitor UCPH-101 exerts sustained inhibition of EAAT1 through an intramonomeric site in the trimerization domain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1068-87. PMID 23325245 DOI: 10.1523/Jneurosci.3396-12.2013  0.436
2012 Winter N, Kovermann P, Fahlke C. A point mutation associated with episodic ataxia 6 increases glutamate transporter anion currents. Brain : a Journal of Neurology. 135: 3416-25. PMID 23107647 DOI: 10.1093/Brain/Aws255  0.522
2012 Weinberger S, Wojciechowski D, Sternberg D, Lehmann-Horn F, Jurkat-Rott K, Becher T, Begemann B, Fahlke C, Fischer M. Disease-causing mutations C277R and C277Y modify gating of human ClC-1 chloride channels in myotonia congenita. The Journal of Physiology. 590: 3449-64. PMID 22641783 DOI: 10.1113/Jphysiol.2012.232785  0.435
2012 Hotzy J, Machtens JP, Fahlke C. Neutralizing aspartate 83 modifies substrate translocation of excitatory amino acid transporter 3 (EAAT3) glutamate transporters. The Journal of Biological Chemistry. 287: 20016-26. PMID 22532568 DOI: 10.1074/Jbc.M112.344077  0.579
2012 Schänzler M, Fahlke C. Anion transport by the cochlear motor protein prestin. The Journal of Physiology. 590: 259-72. PMID 22063625 DOI: 10.1113/Jphysiol.2011.209577  0.484
2012 Grieschat M, Fahlke C, Alekov AK. Lysine 210 Regulates Voltage-Dependent Gating of the Anion-Proton Exchanger CLC-5 Biophysical Journal. 102: 521a. DOI: 10.1016/J.Bpj.2011.11.2848  0.438
2012 Fahlke C. Glutamate Transporter-Associated Anion Channels Biophysical Journal. 102: 407a. DOI: 10.1016/J.Bpj.2011.11.2227  0.542
2011 Machtens JP, Fahlke C, Kovermann P. Noise analysis to study unitary properties of transporter-associated ion channels. Channels (Austin, Tex.). 5: 468-74. PMID 21849820 DOI: 10.4161/Chan.5.6.17453  0.517
2011 Machtens JP, Kovermann P, Fahlke C. Substrate-dependent gating of anion channels associated with excitatory amino acid transporter 4. The Journal of Biological Chemistry. 286: 23780-8. PMID 21572047 DOI: 10.1074/Jbc.M110.207514  0.554
2011 Orhan G, Fahlke C, Alekov AK. Anion- and proton-dependent gating of ClC-4 anion/proton transporter under uncoupling conditions. Biophysical Journal. 100: 1233-41. PMID 21354396 DOI: 10.1016/J.Bpj.2011.01.045  0.495
2011 Fahlke C. Chloride channels take center stage in a muscular drama. The Journal of General Physiology. 137: 17-9. PMID 21149545 DOI: 10.1085/Jgp.201010574  0.379
2011 Nothmann D, Leinenweber A, Torres-Salazar D, Kovermann P, Hotzy J, Gameiro A, Grewer C, Fahlke C. Hetero-oligomerization of neuronal glutamate transporters. The Journal of Biological Chemistry. 286: 3935-43. PMID 21127051 DOI: 10.1074/Jbc.M110.187492  0.788
2011 Leinenweber A, Machtens JP, Begemann B, Fahlke C. Regulation of glial glutamate transporters by C-terminal domains. The Journal of Biological Chemistry. 286: 1927-37. PMID 21097502 DOI: 10.1074/Jbc.M110.153486  0.525
2011 Melzer N, Meuth SG, Torres-Salazar D, Bittner S, Zozulya AL, Weidenfeller C, Kotsiari A, Stangel M, Fahlke C, Wiendl H. Correction: A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis Plos One. 6. DOI: 10.1371/annotation/b1ff1c14-fa84-40a0-b095-e5ee47c74125  0.736
2010 Fahlke C, Fischer M. Physiology and pathophysiology of ClC-K/barttin channels. Frontiers in Physiology. 1: 155. PMID 21423394 DOI: 10.3389/Fphys.2010.00155  0.43
2010 Fischer M, Janssen AG, Fahlke C. Barttin activates ClC-K channel function by modulating gating. Journal of the American Society of Nephrology : Jasn. 21: 1281-9. PMID 20538786 DOI: 10.1681/Asn.2009121274  0.428
2010 Kovermann P, Machtens JP, Ewers D, Fahlke C. A conserved aspartate determines pore properties of anion channels associated with excitatory amino acid transporter 4 (EAAT4). The Journal of Biological Chemistry. 285: 23676-86. PMID 20519505 DOI: 10.1074/Jbc.M110.126557  0.577
2010 Ewers D, Becher T, Krefft R, Hidalgo P, Fahlke C. Characterization of Substrate Binding by the Bacterial Aspartate Transporter GltPh Through Equilibrium and Stopped-Flow Tryptophan Fluorescence Measurements Biophysical Journal. 98: 686a. DOI: 10.1016/J.Bpj.2009.12.3766  0.399
2010 Grieschat M, Fahlke C, Alekov AK. Regulation of the Chloride/Proton Exchanger CLC-5 By Internal pH Biophysical Journal. 98: 319a. DOI: 10.1016/J.Bpj.2009.12.1734  0.42
2009 Haug K, Warnstedt M, Alekov AK, Sander T, Ramírez A, Poser B, Maljevic S, Hebeisen S, Kubisch C, Rebstock J, Horvath S, Hallmann K, Dullinger JS, Rau B, Haverkamp F, ... ... Fahlke C, et al. Retraction: Mutations in CLCN2 encoding a voltage-gated chloride channel are associated with idiopathic generalized epilepsies. Nature Genetics. 41: 1043. PMID 19710717 DOI: 10.1038/Ng0909-1043  0.383
2009 Riazuddin S, Anwar S, Fischer M, Ahmed ZM, Khan SY, Janssen AG, Zafar AU, Scholl U, Husnain T, Belyantseva IA, Friedman PL, Riazuddin S, Friedman TB, Fahlke C. Molecular basis of DFNB73: mutations of BSND can cause nonsyndromic deafness or Bartter syndrome. American Journal of Human Genetics. 85: 273-80. PMID 19646679 DOI: 10.1016/J.Ajhg.2009.07.003  0.334
2009 Alekov AK, Fahlke C. Channel-like slippage modes in the human anion/proton exchanger ClC-4. The Journal of General Physiology. 133: 485-96. PMID 19364886 DOI: 10.1085/Jgp.200810155  0.435
2009 Saint-Martin C, Gauvain G, Teodorescu G, Gourfinkel-An I, Fedirko E, Weber YG, Maljevic S, Ernst JP, Garcia-Olivares J, Fahlke C, Nabbout R, LeGuern E, Lerche H, Poncer JC, Depienne C. Two novel CLCN2 mutations accelerating chloride channel deactivation are associated with idiopathic generalized epilepsy. Human Mutation. 30: 397-405. PMID 19191339 DOI: 10.1002/Humu.20876  0.74
2009 Janssen AG, Scholl U, Domeyer C, Nothmann D, Leinenweber A, Fahlke C. Disease-causing dysfunctions of barttin in Bartter syndrome type IV. Journal of the American Society of Nephrology : Jasn. 20: 145-53. PMID 18776122 DOI: 10.1681/Asn.2008010102  0.416
2009 Kovermann PA, Fahlke C. Voltage-dependent Gating Of Wt And D177a Eaat4-associated Anion Channels Biophysical Journal. 96: 472a. DOI: 10.1016/J.Bpj.2008.12.2429  0.549
2008 Alekov AK, Fahlke C. Anion channels: regulation of ClC-3 by an orphan second messenger. Current Biology : Cb. 18: R1061-4. PMID 19036336 DOI: 10.1016/J.Cub.2008.09.023  0.457
2008 Garcia-Olivares J, Alekov A, Boroumand MR, Begemann B, Hidalgo P, Fahlke C. Gating of human ClC-2 chloride channels and regulation by carboxy-terminal domains. The Journal of Physiology. 586: 5325-36. PMID 18801843 DOI: 10.1113/Jphysiol.2008.158097  0.772
2008 Melzer N, Meuth SG, Torres-Salazar D, Bittner S, Zozulya AL, Weidenfeller C, Kotsiari A, Stangel M, Fahlke C, Wiendl H. A beta-lactam antibiotic dampens excitotoxic inflammatory CNS damage in a mouse model of multiple sclerosis. Plos One. 3: e3149. PMID 18773080 DOI: 10.1371/Journal.Pone.0003149  0.781
2008 Detro-Dassen S, Schänzler M, Lauks H, Martin I, zu Berstenhorst SM, Nothmann D, Torres-Salazar D, Hidalgo P, Schmalzing G, Fahlke C. Conserved dimeric subunit stoichiometry of SLC26 multifunctional anion exchangers. The Journal of Biological Chemistry. 283: 4177-88. PMID 18073211 DOI: 10.1074/Jbc.M704924200  0.755
2008 Melzer N, Meuth SG, Torres-Salazar D, Bittner S, Zozulya AL, Weidenfeller C, Kotsiari A, Stangel M, Fahlke C, Wiendl H. Correction: A β-Lactam Antibiotic Dampens Excitotoxic Inflammatory CNS Damage in a Mouse Model of Multiple Sclerosis Plos One. 3. DOI: 10.1371/annotation/b898d6ee-801a-474e-9776-72e4da664b89  0.736
2007 Torres-Salazar D, Fahlke C. Neuronal glutamate transporters vary in substrate transport rate but not in unitary anion channel conductance. The Journal of Biological Chemistry. 282: 34719-26. PMID 17908688 DOI: 10.1074/Jbc.M704118200  0.803
2007 Torres-Salazar D, Fahlke C. Parawixin1: a spider toxin opening new avenues for glutamate transporter pharmacology. Molecular Pharmacology. 72: 1100-2. PMID 17726155 DOI: 10.1124/Mol.107.041020  0.776
2006 Scholl U, Hebeisen S, Janssen AG, Müller-Newen G, Alekov A, Fahlke C. Barttin modulates trafficking and function of ClC-K channels. Proceedings of the National Academy of Sciences of the United States of America. 103: 11411-6. PMID 16849430 DOI: 10.1073/Pnas.0601631103  0.416
2006 Torres-Salazar D, Fahlke C. Intersubunit interactions in EAAT4 glutamate transporters. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 7513-22. PMID 16837599 DOI: 10.1523/Jneurosci.4545-05.2006  0.802
2005 Melzer N, Torres-Salazar D, Fahlke C. A dynamic switch between inhibitory and excitatory currents in a neuronal glutamate transporter. Proceedings of the National Academy of Sciences of the United States of America. 102: 19214-8. PMID 16365297 DOI: 10.1073/Pnas.0508837103  0.82
2005 Hebeisen S, Fahlke C. Carboxy-terminal truncations modify the outer pore vestibule of muscle chloride channels. Biophysical Journal. 89: 1710-20. PMID 15980168 DOI: 10.1529/Biophysj.104.056093  0.432
2005 Shcherbyna I, Hidalgo P, Fahlke C. Functional characterization of bacterial glutamate transporter reconstituted in lipide membranes Ukrain'Skyi Biokhimichnyi Zhurnal. 77: 75.  0.302
2004 Gendreau S, Voswinkel S, Torres-Salazar D, Lang N, Heidtmann H, Detro-Dassen S, Schmalzing G, Hidalgo P, Fahlke C. A trimeric quaternary structure is conserved in bacterial and human glutamate transporters. The Journal of Biological Chemistry. 279: 39505-12. PMID 15265858 DOI: 10.1074/Jbc.M408038200  0.785
2004 Hebeisen S, Biela A, Giese B, Müller-Newen G, Hidalgo P, Fahlke C. The role of the carboxyl terminus in ClC chloride channel function. The Journal of Biological Chemistry. 279: 13140-7. PMID 14718533 DOI: 10.1074/Jbc.M312649200  0.434
2004 Fahlke C. Molecular physiology and pathophysiology of ClC-type chloride channels Advances in Molecular and Cell Biology. 32: 189-217. DOI: 10.1016/S1569-2558(03)32009-0  0.403
2003 Melzer N, Biela A, Fahlke C. Glutamate modifies ion conduction and voltage-dependent gating of excitatory amino acid transporter-associated anion channels. The Journal of Biological Chemistry. 278: 50112-9. PMID 14506254 DOI: 10.1074/Jbc.M307990200  0.722
2003 Hebeisen S, Heidtmann H, Cosmelli D, Gonzalez C, Poser B, Latorre R, Alvarez O, Fahlke C. Anion permeation in human ClC-4 channels. Biophysical Journal. 84: 2306-18. PMID 12668439 DOI: 10.1016/S0006-3495(03)75036-X  0.441
2002 Ryan A, Rüdel R, Kuchenbecker M, Fahlke C. A novel alteration of muscle chloride channel gating in myotonia levior. The Journal of Physiology. 545: 345-54. PMID 12456816 DOI: 10.1113/Jphysiol.2002.027037  0.453
2002 Wu FF, Ryan A, Devaney J, Warnstedt M, Korade-Mirnics Z, Poser B, Escriva MJ, Pegoraro E, Yee AS, Felice KJ, Giuliani MJ, Mayer RF, Mongini T, Palmucci L, Marino M, ... ... Fahlke C, et al. Novel CLCN1 mutations with unique clinical and electrophysiological consequences. Brain : a Journal of Neurology. 125: 2392-407. PMID 12390967 DOI: 10.1093/Brain/Awf246  0.379
2002 Warnstedt M, Sun C, Poser B, Escriva MJ, Tranebjaerg L, Torbergsen T, van Ghelue M, Fahlke C. The myotonia congenita mutation A331T confers a novel hyperpolarization-activated gate to the muscle chloride channel ClC-1. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 7462-70. PMID 12196568 DOI: 10.1523/Jneurosci.22-17-07462.2002  0.421
2001 Fahlke C. Ion permeation and selectivity in ClC-type chloride channels. American Journal of Physiology. Renal Physiology. 280: F748-57. PMID 11292616 DOI: 10.1152/Ajprenal.2001.280.5.F748  0.413
2001 Fahlke C, Desai RR, Gillani N, George AL. Residues lining the inner pore vestibule of human muscle chloride channels. The Journal of Biological Chemistry. 276: 1759-65. PMID 11035024 DOI: 10.1074/Jbc.M007649200  0.41
2000 Fahlke C. Molecular mechanisms of ion conduction in ClC-type chloride channels: lessons from disease-causing mutations. Kidney International. 57: 780-6. PMID 10720929 DOI: 10.1046/J.1523-1755.2000.00915.X  0.427
1999 Rhodes TH, Vite CH, Giger U, Patterson DF, Fahlke C, George AL. A missense mutation in canine C1C-1 causes recessive myotonia congenita in the dog. Febs Letters. 456: 54-8. PMID 10452529 DOI: 10.1016/S0014-5793(99)00926-6  0.376
1999 Rosenbohm A, Rüdel R, Fahlke C. Regulation of the human skeletal muscle chloride channel hClC-1 by protein kinase C. The Journal of Physiology. 514: 677-85. PMID 9882739 DOI: 10.1111/J.1469-7793.1999.677Ad.X  0.339
1998 Fahlke C, Rhodes TH, Desai RR, George AL. Pore stoichiometry of a voltage-gated chloride channel. Nature. 394: 687-90. PMID 9716133 DOI: 10.1038/29319  0.438
1997 Fahlke C, Yu HT, Beck CL, Rhodes TH, George AL. Pore-forming segments in voltage-gated chloride channels. Nature. 390: 529-32. PMID 9394005 DOI: 10.1038/37391  0.403
1997 Fahlke C, Dürr C, George AL. Mechanism of ion permeation in skeletal muscle chloride channels. The Journal of General Physiology. 110: 551-64. PMID 9348327 DOI: 10.1085/Jgp.110.5.551  0.433
1997 Fahlke C, Beck CL, George AL. A mutation in autosomal dominant myotonia congenita affects pore properties of the muscle chloride channel. Proceedings of the National Academy of Sciences of the United States of America. 94: 2729-34. PMID 9122265 DOI: 10.1073/Pnas.94.6.2729  0.451
1997 Fahlke C, Knittle T, Gurnett CA, Campbell KP, George AL. Subunit stoichiometry of human muscle chloride channels. The Journal of General Physiology. 109: 93-104. PMID 8997668 DOI: 10.1085/Jgp.109.1.93  0.444
1996 Beck CL, Fahlke C, George AL. Molecular basis for decreased muscle chloride conductance in the myotonic goat. Proceedings of the National Academy of Sciences of the United States of America. 93: 11248-52. PMID 8855341 DOI: 10.1073/Pnas.93.20.11248  0.331
1996 Fahlke C, Rosenbohm A, Mitrovic N, George AL, Rüdel R. Mechanism of voltage-dependent gating in skeletal muscle chloride channels. Biophysical Journal. 71: 695-706. PMID 8842208 DOI: 10.1016/S0006-3495(96)79269-X  0.42
1995 Fahlke C, Rüdel R, Mitrovic N, Zhou M, George AL. An aspartic acid residue important for voltage-dependent gating of human muscle chloride channels. Neuron. 15: 463-72. PMID 7646898 DOI: 10.1016/0896-6273(95)90050-0  0.457
1995 Fahlke C, Rüdel R. Chloride currents across the membrane of mammalian skeletal muscle fibres. The Journal of Physiology. 484: 355-68. PMID 7602531 DOI: 10.1113/Jphysiol.1995.Sp020670  0.333
1995 Mitrović N, George AL, Lerche H, Wagner S, Fahlke C, Lehmann-Horn F. Different effects on gating of three myotonia-causing mutations in the inactivation gate of the human muscle sodium channel. The Journal of Physiology. 487: 107-14. PMID 7473241 DOI: 10.1113/Jphysiol.1995.Sp020864  0.423
1994 Mitrović N, George AL, Heine R, Wagner S, Pika U, Hartlaub U, Zhou M, Lerche H, Fahlke C, Lehmann-Horn F. K(+)-aggravated myotonia: destabilization of the inactivated state of the human muscle Na+ channel by the V1589M mutation. The Journal of Physiology. 478: 395-402. PMID 7965854 DOI: 10.1113/Jphysiol.1994.Sp020260  0.436
1993 Fahlke C, Zachar E, Rüdel R. Chloride channels with reduced single-channel conductance in recessive myotonia congenita. Neuron. 10: 225-32. PMID 8382498 DOI: 10.1016/0896-6273(93)90313-G  0.324
1992 Fahlke C, Zachar E, Rüdel R. Single-channel recordings of chloride currents in cultured human skeletal muscle. Pflã¼Gers Archiv : European Journal of Physiology. 421: 108-16. PMID 1382261 DOI: 10.1007/BF00374816  0.326
1988 Fahlke C, Ruppersberg JP. Saturation effects and rectifier properties of sodium channels in human skeletal muscle. European Biophysics Journal : Ebj. 16: 307-12. PMID 2853670 DOI: 10.1007/Bf00254067  0.404
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