| Year |
Citation |
Score |
| 2020 |
Lawal TA, Todd JJ, Witherspoon JW, Bönnemann CG, Dowling JJ, Hamilton SL, Meilleur KG, Dirksen RT. Ryanodine receptor 1-related disorders: an historical perspective and proposal for a unified nomenclature. Skeletal Muscle. 10: 32. PMID 33190635 DOI: 10.1186/s13395-020-00243-4 |
0.44 |
|
| 2020 |
Wang HJ, Lee CS, Yee RSZ, Groom L, Friedman I, Babcock L, Georgiou DK, Hong J, Hanna AD, Recio J, Choi JM, Chang T, Agha NH, Romero J, Sarkar P, ... ... Dirksen RT, et al. Adaptive thermogenesis enhances the life-threatening response to heat in mice with an Ryr1 mutation. Nature Communications. 11: 5099. PMID 33037202 DOI: 10.1038/s41467-020-18865-z |
0.44 |
|
| 2020 |
Michelucci A, Boncompagni S, Pietrangelo L, Takano T, Protasi F, Dirksen RT. Pre-assembled Ca2+ entry units and constitutively active Ca2+ entry in skeletal muscle of calsequestrin-1 knockout mice. The Journal of General Physiology. 152. PMID 32761048 DOI: 10.1085/jgp.202012617 |
0.6 |
|
| 2020 |
Tylock KM, Auerbach DS, Tang ZZ, Thornton CA, Dirksen RT. Biophysical mechanisms for QRS- and QTc-interval prolongation in mice with cardiac expression of expanded CUG-repeat RNA. The Journal of General Physiology. 152. PMID 31968060 DOI: 10.1085/jgp.201912450 |
0.68 |
|
| 2019 |
Michelucci A, Boncompagni S, Pietrangelo L, García-Castañeda M, Takano T, Malik S, Dirksen RT, Protasi F. Transverse tubule remodeling enhances Orai1-dependent Ca entry in skeletal muscle. Elife. 8. PMID 31657717 DOI: 10.7554/eLife.47576 |
0.6 |
|
| 2019 |
Dirksen RT, Wang W, Sheu SS. Introduction. Archives of Biochemistry and Biophysics. PMID 31112707 DOI: 10.1016/j.abb.2019.05.015 |
0.84 |
|
| 2019 |
Yue L, Talukder MAH, Gurjar A, Lee JI, Noble M, Dirksen R, Chakkalakal J, Elfar JC. 4-Aminopyridine attenuates muscle atrophy after sciatic nerve crush injury in mice. Muscle & Nerve. PMID 31093982 DOI: 10.1002/mus.26516 |
0.4 |
|
| 2019 |
Dirksen RT, Allen PD, Lopez JR. Understanding malignant hyperthermia: each move forward opens our eyes to the distance left to travel. British Journal of Anaesthesia. 122: 8-9. PMID 30579410 DOI: 10.1016/j.bja.2018.10.026 |
0.44 |
|
| 2018 |
Boncompagni S, Michelucci A, Pietrangelo L, Dirksen RT, Protasi F. Addendum: Exercise-dependent formation of new junctions that promote STIM1-Orai1 assembly in skeletal muscle. Scientific Reports. 8: 17463. PMID 30479374 DOI: 10.1038/s41598-018-33063-0 |
0.6 |
|
| 2018 |
Michelucci A, García-Castañeda M, Boncompagni S, Dirksen RT. Role of STIM1/ORAI1-mediated store-operated Ca entry in skeletal muscle physiology and disease. Cell Calcium. 76: 101-115. PMID 30414508 DOI: 10.1016/j.ceca.2018.10.004 |
0.6 |
|
| 2017 |
Auerbach DS, Biton Y, Polonsky B, McNitt S, Gross RA, Dirksen RT, Moss AJ. Risk of cardiac events in Long QT syndrome patients when taking antiseizure medications. Translational Research : the Journal of Laboratory and Clinical Medicine. PMID 29121487 DOI: 10.1016/j.trsl.2017.10.002 |
0.36 |
|
| 2017 |
Boncompagni S, Michelucci A, Pietrangelo L, Dirksen RT, Protasi F. Exercise-dependent formation of new junctions that promote STIM1-Orai1 assembly in skeletal muscle. Scientific Reports. 7: 14286. PMID 29079778 DOI: 10.1038/s41598-017-14134-0 |
0.6 |
|
| 2016 |
Linsley JW, Hsu IU, Groom L, Yarotskyy V, Lavorato M, Horstick EJ, Linsley D, Wang W, Franzini-Armstrong C, Dirksen RT, Kuwada JY. Congenital myopathy results from misregulation of a muscle Ca2+ channel by mutant Stac3. Proceedings of the National Academy of Sciences of the United States of America. PMID 28003463 DOI: 10.1073/pnas.1619238114 |
0.56 |
|
| 2016 |
Carrell EM, Coppola AR, McBride HJ, Dirksen RT. Orai1 enhances muscle endurance by promoting fatigue-resistant type I fiber content but not through acute store-operated Ca2+ entry. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 27587568 DOI: 10.1096/fj.201600621R |
0.72 |
|
| 2016 |
Carrell ST, Carrell EM, Auerbach D, Pandey SK, Bennett CF, Dirksen RT, Thornton CA. Dmpk Gene Deletion or Antisense Knockdown Does Not Compromise Cardiac or Skeletal Muscle Function in Mice. Human Molecular Genetics. PMID 27522499 DOI: 10.1093/hmg/ddw266 |
0.72 |
|
| 2016 |
Auerbach DS, McNitt S, Gross RA, Zareba W, Dirksen RT, Moss AJ. Genetic biomarkers for the risk of seizures in long QT syndrome. Neurology. PMID 27466471 DOI: 10.1212/WNL.0000000000003056 |
0.36 |
|
| 2016 |
Wang W, Gong G, Wang X, Wei-LaPierre L, Cheng H, Dirksen RT, Sheu SS. Mitochondrial Flash: Integrative ROS and pH Signals in Cell and Organelle Biology. Antioxidants & Redox Signaling. PMID 27245241 DOI: 10.1089/ars.2016.6739 |
0.84 |
|
| 2015 |
Pietrangelo L, D'Incecco A, Ainbinder A, Michelucci A, Kern H, Dirksen RT, Boncompagni S, Protasi F. Age-dependent uncoupling of mitochondria from Ca2+ release units in skeletal muscle. Oncotarget. PMID 26485763 DOI: 10.18632/oncotarget.6139 |
0.6 |
|
| 2015 |
Georgiou DK, Dagnino-Acosta A, Lee CS, Griffin DM, Wang H, Lagor WR, Pautler RG, Dirksen RT, Hamilton SL. Ca2+ Binding/Permeation via Calcium Channel, CaV1.1, Regulates the Intracellular Distribution of the Fatty Acid Transport Protein, CD36, and Fatty Acid Metabolism. The Journal of Biological Chemistry. PMID 26245899 DOI: 10.1074/jbc.M115.643544 |
0.44 |
|
| 2015 |
Rebbeck RT, Willemse H, Groom L, Casarotto MG, Board PG, Beard NA, Dirksen RT, Dulhunty AF. Regions of ryanodine receptors that influence activation by the dihydropyridine receptor β1a subunit. Skeletal Muscle. 5: 23. PMID 26203350 DOI: 10.1186/s13395-015-0049-3 |
1 |
|
| 2015 |
Michelucci A, Paolini C, Canato M, Wei-Lapierre L, Pietrangelo L, De Marco A, Reggiani C, Dirksen RT, Protasi F. Antioxidants protect calsequestrin-1 knockout mice from halothane- and heat-induced sudden death. Anesthesiology. 123: 603-17. PMID 26132720 DOI: 10.1097/ALN.0000000000000748 |
0.44 |
|
| 2015 |
Paolini C, Quarta M, Wei-LaPierre L, Michelucci A, Nori A, Reggiani C, Dirksen RT, Protasi F. Oxidative stress, mitochondrial damage, and cores in muscle from calsequestrin-1 knockout mice. Skeletal Muscle. 5: 10. PMID 26075051 DOI: 10.1186/s13395-015-0035-9 |
0.44 |
|
| 2015 |
Lee CS, Dagnino-Acosta A, Yarotskyy V, Hanna A, Lyfenko A, Knoblauch M, Georgiou DK, Poché RA, Swank MW, Long C, Ismailov II, Lanner J, Tran T, Dong K, Rodney GG, ... ... Dirksen RT, et al. Ca(2+) permeation and/or binding to CaV1.1 fine-tunes skeletal muscle Ca(2+) signaling to sustain muscle function. Skeletal Muscle. 5: 4. PMID 25717360 DOI: 10.1186/s13395-014-0027-1 |
1 |
|
| 2015 |
Lamboley CR, Kake Guena SA, Touré F, Hébert C, Yaddaden L, Nadeau S, Bouchard P, Wei-LaPierre L, Lainé J, Rousseau EC, Frenette J, Protasi F, Dirksen RT, Pape PC. New method for determining total calcium content in tissue applied to skeletal muscle with and without calsequestrin. The Journal of General Physiology. 145: 127-53. PMID 25624449 DOI: 10.1085/jgp.201411250 |
1 |
|
| 2015 |
Ainbinder A, Boncompagni S, Protasi F, Dirksen RT. Role of Mitofusin-2 in mitochondrial localization and calcium uptake in skeletal muscle. Cell Calcium. 57: 14-24. PMID 25477138 DOI: 10.1016/j.ceca.2014.11.002 |
1 |
|
| 2015 |
Paolini C, Quarta M, Wei-LaPierre L, Michelucci A, Nori A, Reggiani C, Dirksen RT, Protasi F. Oxidative stress, mitochondrial damage, and cores in muscle from calsequestrin-1 knockout mice Skeletal Muscle. DOI: 10.1186/s13395-015-0035-9 |
1 |
|
| 2014 |
Yarotskyy V, Dirksen RT. Monovalent cationic channel activity in the inner membrane of nuclei from skeletal muscle fibers. Biophysical Journal. 107: 2027-36. PMID 25418088 DOI: 10.1016/j.bpj.2014.09.030 |
1 |
|
| 2014 |
Cheng H, Wang W, Wang X, Sheu SS, Dirksen RT, Dong MQ. Cheng et al. reply. Nature. 514: E14-5. PMID 25341791 DOI: 10.1038/nature13859 |
1 |
|
| 2014 |
Riazi S, Kraeva N, Muldoon SM, Dowling J, Ho C, Petre MA, Parness J, Dirksen RT, Rosenberg H. Malignant hyperthermia and the clinical significance of type-1 ryanodine receptor gene (RYR1) variants: proceedings of the 2013 MHAUS Scientific Conference. Canadian Journal of Anaesthesia = Journal Canadien D'AnesthéSie. 61: 1040-9. PMID 25189431 DOI: 10.1007/s12630-014-0227-5 |
1 |
|
| 2014 |
Dowling JJ, Lawlor MW, Dirksen RT. Triadopathies: an emerging class of skeletal muscle diseases. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. 11: 773-85. PMID 25168790 DOI: 10.1007/s13311-014-0300-3 |
1 |
|
| 2014 |
Wagner LE, Groom LA, Dirksen RT, Yule DI. Characterization of ryanodine receptor type 1 single channel activity using "on-nucleus" patch clamp. Cell Calcium. 56: 96-107. PMID 24972488 DOI: 10.1016/j.ceca.2014.05.004 |
1 |
|
| 2014 |
O-Uchi J, Jhun BS, Xu S, Hurst S, Raffaello A, Liu X, Yi B, Zhang H, Gross P, Mishra J, Ainbinder A, Kettlewell S, Smith GL, Dirksen RT, Wang W, et al. Adrenergic signaling regulates mitochondrial Ca2+ uptake through Pyk2-dependent tyrosine phosphorylation of the mitochondrial Ca2+ uniporter. Antioxidants & Redox Signaling. 21: 863-79. PMID 24800979 DOI: 10.1089/ars.2013.5394 |
1 |
|
| 2014 |
Goonasekera SA, Davis J, Kwong JQ, Accornero F, Wei-LaPierre L, Sargent MA, Dirksen RT, Molkentin JD. Enhanced Ca²⺠influx from STIM1-Orai1 induces muscle pathology in mouse models of muscular dystrophy. Human Molecular Genetics. 23: 3706-15. PMID 24556214 DOI: 10.1093/hmg/ddu079 |
1 |
|
| 2014 |
Ram R, Wescott AP, Varandas K, Dirksen RT, Blaxall BC. Mena associates with Rac1 and modulates connexin 43 remodeling in cardiomyocytes. American Journal of Physiology. Heart and Circulatory Physiology. 306: H154-9. PMID 24186093 DOI: 10.1152/ajpheart.00749.2013 |
1 |
|
| 2014 |
Yarotskyy V, Dirksen RT. RGK proteins:Fashioning muscle with "Rad" new brakes Channels. 8: 286-287. DOI: 10.4161/chan.27686 |
1 |
|
| 2014 |
Yarotskyy V, Dirksen RT. Cav1.1 in malignant hyperthermia Pathologies of Calcium Channels. 151-165. DOI: 10.1007/978-3-642-40282-1_8 |
1 |
|
| 2013 |
Wei-Lapierre L, Carrell EM, Boncompagni S, Protasi F, Dirksen RT. Orai1-dependent calcium entry promotes skeletal muscle growth and limits fatigue. Nature Communications. 4: 2805. PMID 24241282 DOI: 10.1038/ncomms3805 |
1 |
|
| 2013 |
Yarotskyy V, Protasi F, Dirksen RT. Accelerated activation of SOCE current in myotubes from two mouse models of anesthetic- and heat-induced sudden death. Plos One. 8: e77633. PMID 24143248 DOI: 10.1371/journal.pone.0077633 |
1 |
|
| 2013 |
Reifler A, Lenk GM, Li X, Groom L, Brooks SV, Wilson D, Bowerson M, Dirksen RT, Meisler MH, Dowling JJ. Murine Fig4 is dispensable for muscle development but required for muscle function. Skeletal Muscle. 3: 21. PMID 24004519 DOI: 10.1186/2044-5040-3-21 |
1 |
|
| 2013 |
Wei-LaPierre L, Gong G, Gerstner BJ, Ducreux S, Yule DI, Pouvreau S, Wang X, Sheu SS, Cheng H, Dirksen RT, Wang W. Respective contribution of mitochondrial superoxide and pH to mitochondria-targeted circularly permuted yellow fluorescent protein (mt-cpYFP) flash activity. The Journal of Biological Chemistry. 288: 10567-77. PMID 23457298 DOI: 10.1074/jbc.M113.455709 |
1 |
|
| 2013 |
Lefebvre R, Legrand C, Groom L, Dirksen RT, Jacquemond V. Ca2+ release in muscle fibers expressing R4892W and G4896V type 1 ryanodine receptor disease mutants. Plos One. 8: e54042. PMID 23308296 DOI: 10.1371/journal.pone.0054042 |
1 |
|
| 2013 |
Kraeva N, Zvaritch E, Rossi AE, Goonasekera SA, Zaid H, Frodis W, Kraev A, Dirksen RT, Maclennan DH, Riazi S. Novel excitation-contraction uncoupled RYR1 mutations in patients with central core disease. Neuromuscular Disorders : Nmd. 23: 120-32. PMID 23183335 DOI: 10.1016/j.nmd.2012.08.007 |
1 |
|
| 2012 |
Loy RE, Lueck JD, Mostajo-Radji MA, Carrell EM, Dirksen RT. Allele-specific gene silencing in two mouse models of autosomal dominant skeletal myopathy. Plos One. 7: e49757. PMID 23152933 DOI: 10.1371/journal.pone.0049757 |
1 |
|
| 2012 |
Yarotskyy V, Dirksen RT. Temperature and RyR1 regulate the activation rate of store-operated Ca²+ entry current in myotubes. Biophysical Journal. 103: 202-11. PMID 22853897 DOI: 10.1016/j.bpj.2012.06.001 |
1 |
|
| 2012 |
Wei L, Dirksen RT. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondrial superoxide flashes: from discovery to new controversies. The Journal of General Physiology. 139: 425-34. PMID 22641637 DOI: 10.1085/jgp.201210790 |
1 |
|
| 2012 |
Sheu SS, Dirksen RT, Pugh EN. Perspectives on: SGP symposium on mitochondrial physiology and medicine: mitochondria take center stage. The Journal of General Physiology. 139: 391-3. PMID 22641633 DOI: 10.1085/jgp.201210819 |
1 |
|
| 2012 |
Lanner JT, Georgiou DK, Dagnino-Acosta A, Ainbinder A, Cheng Q, Joshi AD, Chen Z, Yarotskyy V, Oakes JM, Lee CS, Monroe TO, Santillan A, Dong K, Goodyear L, Ismailov II, ... ... Dirksen RT, et al. AICAR prevents heat-induced sudden death in RyR1 mutant mice independent of AMPK activation. Nature Medicine. 18: 244-51. PMID 22231556 DOI: 10.1038/nm.2598 |
1 |
|
| 2012 |
Liu X, Yu L, Wang Q, Pelletier J, Fausther M, Sévigny J, Malmström HS, Dirksen RT, Ren YF. Expression of ecto-ATPase NTPDase2 in human dental pulp. Journal of Dental Research. 91: 261-7. PMID 22173326 DOI: 10.1177/0022034511431582 |
1 |
|
| 2012 |
Tang ZZ, Yarotskyy V, Wei L, Sobczak K, Nakamori M, Eichinger K, Moxley RT, Dirksen RT, Thornton CA. Muscle weakness in myotonic dystrophy associated with misregulated splicing and altered gating of Ca(V)1.1 calcium channel. Human Molecular Genetics. 21: 1312-24. PMID 22140091 DOI: 10.1093/hmg/ddr568 |
1 |
|
| 2012 |
Jhun BS, O-Uchi J, Wang W, Ha CH, Zhao J, Kim JY, Wong C, Dirksen RT, Lopes CM, Jin ZG. Adrenergic signaling controls RGK-dependent trafficking of cardiac voltage-gated L-type Ca2+ channels through PKD1. Circulation Research. 110: 59-70. PMID 22076634 DOI: 10.1161/CIRCRESAHA.111.254672 |
1 |
|
| 2011 |
Sheu SS, Dirksen RT, Pugh EN. The 65th Symposium of the Society for General Physiologists: energizing research in mitochondrial physiology and medicine. The Journal of General Physiology. 138: 563-7. PMID 22124113 DOI: 10.1085/jgp.201110739 |
1 |
|
| 2011 |
Lefebvre R, Legrand C, González-RodrÃguez E, Groom L, Dirksen RT, Jacquemond V. Defects in Ca2+ release associated with local expression of pathological ryanodine receptors in mouse muscle fibres. The Journal of Physiology. 589: 5361-82. PMID 21969454 DOI: 10.1113/jphysiol.2011.216408 |
1 |
|
| 2011 |
Huang Z, Zhang W, Fang H, Zheng M, Wang X, Xu J, Cheng H, Gong G, Wang W, Dirksen RT, Sheu SS. Response to "A critical evaluation of cpYFP as a probe for superoxide". Free Radical Biology & Medicine. 51: 1937-40. PMID 21925593 DOI: 10.1016/j.freeradbiomed.2011.08.024 |
1 |
|
| 2011 |
Groom L, Muldoon SM, Tang ZZ, Brandom BW, Bayarsaikhan M, Bina S, Lee HS, Qiu X, Sambuughin N, Dirksen RT. Identical de novo mutation in the type 1 ryanodine receptor gene associated with fatal, stress-induced malignant hyperthermia in two unrelated families. Anesthesiology. 115: 938-45. PMID 21918424 DOI: 10.1097/ALN.0b013e3182320068 |
1 |
|
| 2011 |
Rossi AE, Boncompagni S, Wei L, Protasi F, Dirksen RT. Differential impact of mitochondrial positioning on mitochondrial Ca(2+) uptake and Ca(2+) spark suppression in skeletal muscle. American Journal of Physiology. Cell Physiology. 301: C1128-39. PMID 21849670 DOI: 10.1152/ajpcell.00194.2011 |
1 |
|
| 2011 |
Wei L, Salahura G, Boncompagni S, Kasischke KA, Protasi F, Sheu SS, Dirksen RT. Mitochondrial superoxide flashes: metabolic biomarkers of skeletal muscle activity and disease. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 25: 3068-78. PMID 21646399 DOI: 10.1096/fj.11-187252 |
1 |
|
| 2011 |
Ryu SY, Beutner G, Kinnally KW, Dirksen RT, Sheu SS. Single channel characterization of the mitochondrial ryanodine receptor in heart mitoplasts. The Journal of Biological Chemistry. 286: 21324-9. PMID 21524998 DOI: 10.1074/jbc.C111.245597 |
1 |
|
| 2011 |
Tae H, Wei L, Willemse H, Mirza S, Gallant EM, Board PG, Dirksen RT, Casarotto MG, Dulhunty A. The elusive role of the SPRY2 domain in RyR1. Channels (Austin, Tex.). 5: 148-60. PMID 21239886 |
1 |
|
| 2011 |
Loy RE, Orynbayev M, Xu L, Andronache Z, Apostol S, Zvaritch E, MacLennan DH, Meissner G, Melzer W, Dirksen RT. Muscle weakness in Ryr1I4895T/WT knock-in mice as a result of reduced ryanodine receptor Ca2+ ion permeation and release from the sarcoplasmic reticulum. The Journal of General Physiology. 137: 43-57. PMID 21149547 DOI: 10.1085/jgp.201010523 |
1 |
|
| 2011 |
Lueck JD, Rossi AE, Thornton CA, Campbell KP, Dirksen RT. Response to the letter: "On the localization of ClC-1 in skeletal muscle fibers" Journal of General Physiology. 137: 331-333. DOI: 10.1085/jgp.201010589 |
1 |
|
| 2010 |
Wei L, Dirksen RT. Ryanodinopathies: RyR-Linked Muscle Diseases. Current Topics in Membranes. 66: 139-67. PMID 22353479 DOI: 10.1016/S1063-5823(10)66007-3 |
1 |
|
| 2010 |
Lueck JD, Rossi AE, Thornton CA, Campbell KP, Dirksen RT. Sarcolemmal-restricted localization of functional ClC-1 channels in mouse skeletal muscle. The Journal of General Physiology. 136: 597-613. PMID 21078869 DOI: 10.1085/jgp.201010526 |
1 |
|
| 2010 |
Boncompagni S, Loy RE, Dirksen RT, Franzini-Armstrong C. The I4895T mutation in the type 1 ryanodine receptor induces fiber-type specific alterations in skeletal muscle that mimic premature aging. Aging Cell. 9: 958-70. PMID 20961389 DOI: 10.1111/j.1474-9726.2010.00623.x |
1 |
|
| 2010 |
Dirksen RT, Pugh EN. Emerging questions about the macromolecular machines of muscle. The Journal of General Physiology. 136: 3-5. PMID 20584886 DOI: 10.1085/jgp.201010481 |
1 |
|
| 2010 |
Ryu SY, Beutner G, Dirksen RT, Kinnally KW, Sheu SS. Mitochondrial ryanodine receptors and other mitochondrial Ca2+ permeable channels. Febs Letters. 584: 1948-55. PMID 20096690 DOI: 10.1016/j.febslet.2010.01.032 |
1 |
|
| 2010 |
Zhou H, Lillis S, Loy RE, Ghassemi F, Rose MR, Norwood F, Mills K, Al-Sarraj S, Lane RJ, Feng L, Matthews E, Sewry CA, Abbs S, Buk S, Hanna M, ... ... Dirksen RT, et al. Multi-minicore disease and atypical periodic paralysis associated with novel mutations in the skeletal muscle ryanodine receptor (RYR1) gene. Neuromuscular Disorders : Nmd. 20: 166-73. PMID 20080402 DOI: 10.1016/j.nmd.2009.12.005 |
1 |
|
| 2009 |
Boncompagni S, Rossi AE, Micaroni M, Hamilton SL, Dirksen RT, Franzini-Armstrong C, Protasi F. Characterization and temporal development of cores in a mouse model of malignant hyperthermia. Proceedings of the National Academy of Sciences of the United States of America. 106: 21996-2001. PMID 19966218 DOI: 10.1073/pnas.0911496106 |
1 |
|
| 2009 |
Dirksen RT, Bannister RA. The 63rd Symposium of the Society of General Physiologists: "muscles" instead of squid at Woods Hole. The Journal of General Physiology. 134: 453-5. PMID 19948997 DOI: 10.1085/jgp.200910363 |
1 |
|
| 2009 |
Wheeler TM, Sobczak K, Lueck JD, Osborne RJ, Lin X, Dirksen RT, Thornton CA. Reversal of RNA dominance by displacement of protein sequestered on triplet repeat RNA. Science (New York, N.Y.). 325: 336-9. PMID 19608921 DOI: 10.1126/science.1173110 |
1 |
|
| 2009 |
Dirksen RT. Sarcoplasmic reticulum-mitochondrial through-space coupling in skeletal muscle. Applied Physiology, Nutrition, and Metabolism = Physiologie AppliquéE, Nutrition Et MéTabolisme. 34: 389-95. PMID 19448704 DOI: 10.1139/H09-044 |
1 |
|
| 2009 |
Dirksen RT. Checking your SOCCs and feet: the molecular mechanisms of Ca2+ entry in skeletal muscle. The Journal of Physiology. 587: 3139-47. PMID 19406875 DOI: 10.1113/jphysiol.2009.172148 |
1 |
|
| 2009 |
Fallon JL, Baker MR, Xiong L, Loy RE, Yang G, Dirksen RT, Hamilton SL, Quiocho FA. Crystal structure of dimeric cardiac L-type calcium channel regulatory domains bridged by Ca2+* calmodulins. Proceedings of the National Academy of Sciences of the United States of America. 106: 5135-40. PMID 19279214 DOI: 10.1073/pnas.0807487106 |
1 |
|
| 2009 |
Andronache Z, Hamilton SL, Dirksen RT, Melzer W. A retrograde signal from RyR1 alters DHP receptor inactivation and limits window Ca2+ release in muscle fibers of Y522S RyR1 knock-in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 4531-6. PMID 19246389 DOI: 10.1073/pnas.0812661106 |
1 |
|
| 2009 |
Dainese M, Quarta M, Lyfenko AD, Paolini C, Canato M, Reggiani C, Dirksen RT, Protasi F. Anesthetic- and heat-induced sudden death in calsequestrin-1-knockout mice. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 1710-20. PMID 19237502 DOI: 10.1096/fj.08-121335 |
1 |
|
| 2009 |
Kimura T, Lueck JD, Harvey PJ, Pace SM, Ikemoto N, Casarotto MG, Dirksen RT, Dulhunty AF. Alternative splicing of RyR1 alters the efficacy of skeletal EC coupling. Cell Calcium. 45: 264-74. PMID 19131108 DOI: 10.1016/j.ceca.2008.11.005 |
1 |
|
| 2009 |
Rossi AE, Boncompagni S, Dirksen RT. Sarcoplasmic reticulum-mitochondrial symbiosis: bidirectional signaling in skeletal muscle. Exercise and Sport Sciences Reviews. 37: 29-35. PMID 19098522 DOI: 10.1097/JES.0b013e3181911fa4 |
1 |
|
| 2009 |
Boncompagni S, Rossi AE, Micaroni M, Beznoussenko GV, Polishchuk RS, Dirksen RT, Protasi F. Mitochondria are linked to calcium stores in striated muscle by developmentally regulated tethering structures. Molecular Biology of the Cell. 20: 1058-67. PMID 19037102 DOI: 10.1091/mbc.E08-07-0783 |
1 |
|
| 2009 |
Oestreich EA, Malik S, Goonasekera SA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV. Epac and phospholipase Cepsilon regulate Ca2+ release in the heart by activation of protein kinase Cepsilon and calcium-calmodulin kinase II. The Journal of Biological Chemistry. 284: 1514-22. PMID 18957419 DOI: 10.1074/jbc.M806994200 |
1 |
|
| 2008 |
Sheu SS, Wang W, Cheng H, Dirksen RT. Superoxide flashes: illuminating new insights into cardiac ischemia/reperfusion injury. Future Cardiology. 4: 551-554. PMID 19649173 |
0.84 |
|
| 2008 |
Lyfenko AD, Dirksen RT. Differential dependence of store-operated and excitation-coupled Ca2+ entry in skeletal muscle on STIM1 and Orai1. The Journal of Physiology. 586: 4815-24. PMID 18772199 DOI: 10.1113/jphysiol.2008.160481 |
1 |
|
| 2008 |
Wang W, Fang H, Groom L, Cheng A, Zhang W, Liu J, Wang X, Li K, Han P, Zheng M, Yin J, Wang W, Mattson MP, Kao JP, Lakatta EG, ... ... Dirksen RT, et al. Superoxide flashes in single mitochondria. Cell. 134: 279-90. PMID 18662543 DOI: 10.1016/j.cell.2008.06.017 |
1 |
|
| 2008 |
Durham WJ, Aracena-Parks P, Long C, Rossi AE, Goonasekera SA, Boncompagni S, Galvan DL, Gilman CP, Baker MR, Shirokova N, Protasi F, Dirksen R, Hamilton SL. RyR1 S-nitrosylation underlies environmental heat stroke and sudden death in Y522S RyR1 knockin mice. Cell. 133: 53-65. PMID 18394989 DOI: 10.1016/j.cell.2008.02.042 |
1 |
|
| 2007 |
Wheeler TM, Lueck JD, Swanson MS, Dirksen RT, Thornton CA. Correction of ClC-1 splicing eliminates chloride channelopathy and myotonia in mouse models of myotonic dystrophy. The Journal of Clinical Investigation. 117: 3952-7. PMID 18008009 DOI: 10.1172/JCI33355 |
1 |
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| 2007 |
Zvaritch E, Depreux F, Kraeva N, Loy RE, Goonasekera SA, Boncompagni S, Boncompagi S, Kraev A, Gramolini AO, Dirksen RT, Franzini-Armstrong C, Seidman CE, Seidman JG, Maclennan DH. An Ryr1I4895T mutation abolishes Ca2+ release channel function and delays development in homozygous offspring of a mutant mouse line. Proceedings of the National Academy of Sciences of the United States of America. 104: 18537-42. PMID 18003898 DOI: 10.1073/pnas.0709312104 |
1 |
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| 2007 |
Smrcka AV, Oestreich EA, Blaxall BC, Dirksen RT. EPAC regulation of cardiac EC coupling. The Journal of Physiology. 584: 1029-31. PMID 17884917 DOI: 10.1113/jphysiol.2007.145037 |
1 |
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| 2007 |
Goonasekera SA, Beard NA, Groom L, Kimura T, Lyfenko AD, Rosenfeld A, Marty I, Dulhunty AF, Dirksen RT. Triadin binding to the C-terminal luminal loop of the ryanodine receptor is important for skeletal muscle excitation contraction coupling. The Journal of General Physiology. 130: 365-78. PMID 17846166 DOI: 10.1085/jgp.200709790 |
1 |
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| 2007 |
Rossi D, De Smet P, Lyfenko A, Galli L, Lorenzini S, Franci D, Petrioli F, Orrico A, Angelini C, Tegazzin V, Dirksen R, Sorrentino V. A truncation in the RYR1 gene associated with central core lesions in skeletal muscle fibres Journal of Medical Genetics. 44: e67. PMID 17293538 DOI: 10.1136/jmg.2006.043794 |
1 |
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| 2007 |
Oestreich EA, Wang H, Malik S, Kaproth-Joslin KA, Blaxall BC, Kelley GG, Dirksen RT, Smrcka AV. Epac-mediated activation of phospholipase C(epsilon) plays a critical role in beta-adrenergic receptor-dependent enhancement of Ca2+ mobilization in cardiac myocytes. The Journal of Biological Chemistry. 282: 5488-95. PMID 17178726 DOI: 10.1074/jbc.M608495200 |
1 |
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| 2007 |
Lueck JD, Mankodi A, Swanson MS, Thornton CA, Dirksen RT. Muscle chloride channel dysfunction in two mouse models of myotonic dystrophy. The Journal of General Physiology. 129: 79-94. PMID 17158949 DOI: 10.1085/jgp.200609635 |
1 |
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| 2007 |
Lueck JD, Lungu C, Mankodi A, Osborne RJ, Welle SL, Dirksen RT, Thornton CA. Chloride channelopathy in myotonic dystrophy resulting from loss of posttranscriptional regulation for CLCN1. American Journal of Physiology. Cell Physiology. 292: C1291-7. PMID 17135300 DOI: 10.1152/ajpcell.00336.2006 |
1 |
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| 2007 |
Kimura T, Pace SM, Wei L, Beard NA, Dirksen RT, Dulhunty AF. A variably spliced region in the type 1 ryanodine receptor may participate in an inter-domain interaction. The Biochemical Journal. 401: 317-24. PMID 16989644 DOI: 10.1042/BJ20060686 |
1 |
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| 2007 |
Lyfenko AD, Ducreux S, Wang Y, Xu L, Zorzato F, Ferreiro A, Meissner G, Treves S, Dirksen RT. Two central core disease (CCD) deletions in the C-terminal region of RYR1 alter muscle excitation-contraction (EC) coupling by distinct mechanisms. Human Mutation. 28: 61-8. PMID 16958053 DOI: 10.1002/humu.20409 |
1 |
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| 2006 |
Aracena-Parks P, Goonasekera SA, Gilman CP, Dirksen RT, Hidalgo C, Hamilton SL. Identification of cysteines involved in S-nitrosylation, S-glutathionylation, and oxidation to disulfides in ryanodine receptor type 1. The Journal of Biological Chemistry. 281: 40354-68. PMID 17071618 DOI: 10.1074/jbc.M600876200 |
1 |
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| 2006 |
Kannankeril PJ, Mitchell BM, Goonasekera SA, Chelu MG, Zhang W, Sood S, Kearney DL, Danila CI, De Biasi M, Wehrens XH, Pautler RG, Roden DM, Taffet GE, Dirksen RT, Anderson ME, et al. Mice with the R176Q cardiac ryanodine receptor mutation exhibit catecholamine-induced ventricular tachycardia and cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 103: 12179-84. PMID 16873551 DOI: 10.1073/pnas.0600268103 |
1 |
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| 2006 |
Rossi AE, Dirksen RT. Sarcoplasmic reticulum: the dynamic calcium governor of muscle. Muscle & Nerve. 33: 715-31. PMID 16477617 DOI: 10.1002/mus.20512 |
1 |
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| 2006 |
Chelu MG, Goonasekera SA, Durham WJ, Tang W, Lueck JD, Riehl J, Pessah IN, Zhang P, Bhattacharjee MB, Dirksen RT, Hamilton SL. Heat- and anesthesia-induced malignant hyperthermia in an RyR1 knock-in mouse. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 20: 329-30. PMID 16284304 DOI: 10.1096/fj.05-4497fje |
1 |
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| 2005 |
Wang H, Oestreich EA, Maekawa N, Bullard TA, Vikstrom KL, Dirksen RT, Kelley GG, Blaxall BC, Smrcka AV. Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy. Circulation Research. 97: 1305-13. PMID 16293787 DOI: 10.1161/01.RES.0000196578.15385.bb |
1 |
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| 2005 |
Beutner G, Sharma VK, Lin L, Ryu SY, Dirksen RT, Sheu SS. Type 1 ryanodine receptor in cardiac mitochondria: transducer of excitation-metabolism coupling. Biochimica Et Biophysica Acta. 1717: 1-10. PMID 16246297 DOI: 10.1016/j.bbamem.2005.09.016 |
1 |
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| 2005 |
Goonasekera SA, Chen SR, Dirksen RT. Reconstitution of local Ca2+ signaling between cardiac L-type Ca2+ channels and ryanodine receptors: insights into regulation by FKBP12.6. American Journal of Physiology. Cell Physiology. 289: C1476-84. PMID 16049053 DOI: 10.1152/ajpcell.00250.2005 |
1 |
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| 2005 |
Kimura T, Nakamori M, Lueck JD, Pouliquin P, Aoike F, Fujimura H, Dirksen RT, Takahashi MP, Dulhunty AF, Sakoda S. Altered mRNA splicing of the skeletal muscle ryanodine receptor and sarcoplasmic/endoplasmic reticulum Ca2+-ATPase in myotonic dystrophy type 1. Human Molecular Genetics. 14: 2189-200. PMID 15972723 DOI: 10.1093/hmg/ddi223 |
1 |
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| 2005 |
Avila G, Dirksen RT. Rapamycin and FK506 reduce skeletal muscle voltage sensor expression and function. Cell Calcium. 38: 35-44. PMID 15955561 DOI: 10.1016/j.ceca.2005.05.001 |
1 |
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| 2004 |
Dirksen RT, Avila G. Distinct effects on Ca2+ handling caused by malignant hyperthermia and central core disease mutations in RyR1. Biophysical Journal. 87: 3193-204. PMID 15347586 DOI: 10.1529/biophysj.104.048447 |
1 |
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| 2004 |
Lyfenko AD, Goonasekera SA, Dirksen RT. Dynamic alterations in myoplasmic Ca2+ in malignant hyperthermia and central core disease. Biochemical and Biophysical Research Communications. 322: 1256-66. PMID 15336973 DOI: 10.1016/j.bbrc.2004.08.031 |
1 |
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| 2004 |
Du GG, Avila G, Sharma P, Khanna VK, Dirksen RT, MacLennan DH. Role of the sequence surrounding predicted transmembrane helix M4 in membrane association and function of the Ca(2+) release channel of skeletal muscle sarcoplasmic reticulum (ryanodine receptor isoform 1). The Journal of Biological Chemistry. 279: 37566-74. PMID 15226293 DOI: 10.1074/jbc.M406637200 |
1 |
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| 2004 |
Weiss RG, O'Connell KM, Flucher BE, Allen PD, Grabner M, Dirksen RT. Functional analysis of the R1086H malignant hyperthermia mutation in the DHPR reveals an unexpected influence of the III-IV loop on skeletal muscle EC coupling. American Journal of Physiology. Cell Physiology. 287: C1094-102. PMID 15201141 DOI: 10.1152/ajpcell.00173.2004 |
1 |
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| 2003 |
He X, Liu Y, Sharma V, Dirksen RT, Waugh R, Sheu SS, Min W. ASK1 associates with troponin T and induces troponin T phosphorylation and contractile dysfunction in cardiomyocytes. The American Journal of Pathology. 163: 243-51. PMID 12819028 DOI: 10.1016/S0002-9440(10)63647-4 |
1 |
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| 2003 |
Leuranguer V, Dirksen RT, Beam KG. Potentiated L-type Ca2+ channels rectify. The Journal of General Physiology. 121: 541-50. PMID 12743165 DOI: 10.1085/jgp.200308833 |
1 |
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| 2003 |
Avila G, Lee EH, Perez CF, Allen PD, Dirksen RT. FKBP12 binding to RyR1 modulates excitation-contraction coupling in mouse skeletal myotubes. The Journal of Biological Chemistry. 278: 22600-8. PMID 12704193 DOI: 10.1074/jbc.M205866200 |
1 |
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| 2003 |
Avila G, O'Connell KM, Dirksen RT. The pore region of the skeletal muscle ryanodine receptor is a primary locus for excitation-contraction uncoupling in central core disease. The Journal of General Physiology. 121: 277-86. PMID 12642598 DOI: 10.1085/jgp.200308791 |
1 |
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| 2002 |
Dirksen RT. Reactive oxygen/nitrogen species and the aged brain: radical impact of ion channel function. Neurobiology of Aging. 23: 837-9; discussion 84. PMID 12392787 DOI: 10.1016/S0197-4580(02)00071-4 |
1 |
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| 2002 |
Papineni RV, O'Connell KM, Zhang H, Dirksen RT, Hamilton SL. Suramin interacts with the calmodulin binding site on the ryanodine receptor, RYR1. The Journal of Biological Chemistry. 277: 49167-74. PMID 12364321 DOI: 10.1074/jbc.M209564200 |
1 |
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| 2002 |
O'Connell KM, Yamaguchi N, Meissner G, Dirksen RT. Calmodulin binding to the 3614-3643 region of RyR1 is not essential for excitation-contraction coupling in skeletal myotubes. The Journal of General Physiology. 120: 337-47. PMID 12198090 DOI: 10.1085/jgp.20028617 |
1 |
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| 2002 |
Dirksen RT, Avila G. Altered ryanodine receptor function in central core disease: leaky or uncoupled Ca(2+) release channels? Trends in Cardiovascular Medicine. 12: 189-97. PMID 12161072 DOI: 10.1016/S1050-1738(02)00163-9 |
1 |
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| 2002 |
Alano CC, Beutner G, Dirksen RT, Gross RA, Sheu SS. Mitochondrial permeability transition and calcium dynamics in striatal neurons upon intense NMDA receptor activation. Journal of Neurochemistry. 80: 531-8. PMID 11905998 DOI: 10.1046/j.0022-3042.2001.00738.x |
1 |
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| 2002 |
Dirksen RT. Bi-directional coupling between dihydropyridine receptors and ryanodine receptors. Frontiers in Bioscience : a Journal and Virtual Library. 7: d659-70. PMID 11861208 |
1 |
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| 2001 |
Avila G, Dirksen RT. Functional effects of central core disease mutations in the cytoplasmic region of the skeletal muscle ryanodine receptor. The Journal of General Physiology. 118: 277-90. PMID 11524458 DOI: 10.1085/jgp.118.3.277 |
1 |
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| 2001 |
Avila G, O'Connell KM, Groom LA, Dirksen RT. Ca2+ release through ryanodine receptors regulates skeletal muscle L-type Ca2+ channel expression. The Journal of Biological Chemistry. 276: 17732-8. PMID 11278546 DOI: 10.1074/jbc.M009685200 |
1 |
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| 2001 |
Avila G, O'Brien JJ, Dirksen RT. Excitation--contraction uncoupling by a human central core disease mutation in the ryanodine receptor. Proceedings of the National Academy of Sciences of the United States of America. 98: 4215-20. PMID 11274444 DOI: 10.1073/pnas.071048198 |
1 |
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| 2000 |
O'Connell KM, Dirksen RT. Prolonged depolarization promotes fast gating kinetics of L-type Ca2+ channels in mouse skeletal myotubes. The Journal of Physiology. 529: 647-59. PMID 11118495 DOI: 10.1111/j.1469-7793.2000.00647.x |
1 |
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| 2000 |
Suda N, Dirksen RT, Gonzalez A, Beam KG. Low serum promotes maturation of excitation-contraction coupling in myotubes. PflüGers Archiv : European Journal of Physiology. 439: 555-8. PMID 10764214 DOI: 10.1007/s004240050977 |
1 |
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| 2000 |
Avila G, Dirksen RT. Functional impact of the ryanodine receptor on the skeletal muscle L-type Ca(2+) channel. The Journal of General Physiology. 115: 467-80. PMID 10736313 DOI: 10.1085/jgp.115.4.467 |
1 |
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| 1999 |
Dirksen RT, Beam KG. Role of calcium permeation in dihydropyridine receptor function. Insights into channel gating and excitation-contraction coupling. The Journal of General Physiology. 114: 393-403. PMID 10469729 DOI: 10.1085/jgp.114.3.393 |
1 |
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| 1999 |
Grabner M, Dirksen RT, Suda N, Beam KG. The II-III loop of the skeletal muscle dihydropyridine receptor is responsible for the Bi-directional coupling with the ryanodine receptor. The Journal of Biological Chemistry. 274: 21913-9. PMID 10419512 DOI: 10.1074/jbc.274.31.21913 |
1 |
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| 1998 |
Grabner M, Dirksen RT, Beam KG. Tagging with green fluorescent protein reveals a distinct subcellular distribution of L-type and non-L-type Ca2+ channels expressed in dysgenic myotubes. Proceedings of the National Academy of Sciences of the United States of America. 95: 1903-8. PMID 9465115 DOI: 10.1073/pnas.95.4.1903 |
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| 1997 |
Dirksen RT, Nakai J, Gonzalez A, Imoto K, Beam KG. The S5-S6 linker of repeat I is a critical determinant of L-type Ca2+ channel conductance. Biophysical Journal. 73: 1402-9. PMID 9284307 DOI: 10.1016/S0006-3495(97)78172-4 |
1 |
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| 1996 |
Dirksen RT, Beam KG. Unitary behavior of skeletal, cardiac, and chimeric L-type Ca2+ channels expressed in dysgenic myotubes. The Journal of General Physiology. 107: 731-42. PMID 8783073 |
1 |
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| 1996 |
Nakai J, Dirksen RT, Nguyen HT, Pessah IN, Beam KG, Allen PD. Enhanced dihydropyridine receptor channel activity in the presence of ryanodine receptor. Nature. 380: 72-5. PMID 8598910 DOI: 10.1038/380072a0 |
1 |
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| 1995 |
Dirksen RT, Beam KG. Single calcium channel behavior in native skeletal muscle. The Journal of General Physiology. 105: 227-47. PMID 7539048 DOI: 10.1085/jgp.105.2.227 |
1 |
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| 1994 |
Arreola J, Dirksen RT, Perez-Cornejo P, Piech KM, Sheu SS. Autonomic modulation of action potential and tension in guinea pig papillary muscles. European Journal of Pharmacology. 271: 309-17. PMID 7705431 DOI: 10.1016/0014-2999(94)90788-9 |
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| 1993 |
Mori Y, Niidome T, Fujita Y, Mynlieff M, Dirksen RT, Beam KG, Iwabe N, Miyata T, Furutama D, Furuichi T. Molecular diversity of voltage-dependent calcium channel. Annals of the New York Academy of Sciences. 707: 87-108. PMID 9137545 DOI: 10.1111/j.1749-6632.1993.tb38045.x |
1 |
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| 1993 |
Fujita Y, Mynlieff M, Dirksen RT, Kim MS, Niidome T, Nakai J, Friedrich T, Iwabe N, Miyata T, Furuichi T. Primary structure and functional expression of the omega-conotoxin-sensitive N-type calcium channel from rabbit brain. Neuron. 10: 585-98. PMID 8386525 DOI: 10.1016/0896-6273(93)90162-K |
1 |
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| 1991 |
Sheu SS, Sharma VK, Korth M, Moscucci A, Dirksen RT, Jou MJ. Receptor-mediated inotropic effect in heart. Role of sodium-calcium exchange. Annals of the New York Academy of Sciences. 639: 398-407. PMID 1664703 DOI: 10.1111/j.1749-6632.1991.tb17328.x |
1 |
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| 1991 |
Arreola J, Dirksen RT, Shieh RC, Williford DJ, Sheu SS. Ca2+ current and Ca2+ transients under action potential clamp in guinea pig ventricular myocytes. The American Journal of Physiology. 261: C393-7. PMID 1651654 |
1 |
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| 1990 |
Enyeart JJ, Dirksen RT, Sharma VK, Williford DJ, Sheu SS. Antipsychotic pimozide is a potent Ca2+ channel blocker in heart. Molecular Pharmacology. 37: 752-7. PMID 2160063 |
1 |
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| 1990 |
Dirksen RT, Sheu SS. Modulation of ventricular action potential by alpha 1-adrenoceptors and protein kinase C. The American Journal of Physiology. 258: H907-11. PMID 2156457 |
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