Francesco Zorzato, PhD - Publications

Affiliations: 
Dipartimento di Medicina Sperimentale e Diagnostica Sezione di Patologia Generale  Universtà di Ferrara 

136 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Benucci S, Ruiz A, Franchini M, Ruggiero L, Zoppi D, Sitsapesan R, Lindsay C, Pelczar P, Pietrangelo L, Protasi F, Treves S, Zorzato F. A novel, patient-derived RyR1 mutation impairs muscle function and calcium homeostasis in mice. The Journal of General Physiology. 156. PMID 38445312 DOI: 10.1085/jgp.202313486  0.399
2023 Eckhardt J, Ruiz A, Koenig S, Frieden M, Meier H, Schmidt A, Treves S, Zorzato F. Quantitative proteomic analysis of skeletal muscles from wild-type and transgenic mice carrying recessive mutations linked to congenital myopathies. Elife. 12. PMID 36862731 DOI: 10.7554/eLife.83618  0.44
2022 Bachmann C, Franchini M, Van den Bersselaar LR, Kruijt N, Voermans NC, Bouman K, Kamsteeg EJ, Knop KC, Ruggiero L, Santoro L, Nevo Y, Wilmshurst J, Vissing J, Sinnreich M, Zorzato D, ... ... Zorzato F, et al. Targeted transcript analysis in muscles from patients with genetically diverse congenital myopathies. Brain Communications. 4: fcac224. PMID 36196089 DOI: 10.1093/braincomms/fcac224  0.426
2022 Ruiz A, Benucci S, Duthaler U, Bachmann C, Franchini M, Noreen F, Pietrangelo L, Protasi F, Treves S, Zorzato F. Improvement of muscle strength in a mouse model for congenital myopathy treated with HDAC and DNA methyltransferase inhibitors. Elife. 11. PMID 35238775 DOI: 10.7554/eLife.73718  0.381
2022 Ruizl A, Eckhardt J, Treves S, Zorzato F. Molecular basis of impaired muscle function in a mouse model of congenital myopathy due to compound heterozygous RYR1 mutations. The Journal of General Physiology. 154. PMID 34766998 DOI: 10.1085/jgp.2021ecc26  0.421
2021 Treves S, Girard T, Zorzato F. Functional Characterization of Endogenously Expressed Human RYR1 Variants. Journal of Visualized Experiments : Jove. PMID 34180878 DOI: 10.3791/62196  0.36
2021 Reddish FN, Miller CL, Deng X, Dong B, Patel AA, Ghane MA, Mosca B, McBean C, Wu S, Solntsev KM, Zhuo Y, Gadda G, Fang N, Cox DN, Mabb AM, ... ... Zorzato F, et al. Rapid subcellular calcium responses and dynamics by calcium sensor G-CatchER. Iscience. 24: 102129. PMID 33665552 DOI: 10.1016/j.isci.2021.102129  0.314
2020 Elbaz M, Ruiz A, Nicolay S, Tupini C, Bachmann C, Eckhardt J, Benucci S, Pelczar P, Treves S, Zorzato F. Bi-allelic expression of the RyR1 p.A4329D mutation decreases muscle strength in slow- twitch muscles in mice. The Journal of Biological Chemistry. PMID 32499372 DOI: 10.1074/Jbc.Ra120.013846  0.45
2020 Eckhardt J, Bachmann C, Benucci S, Elbaz M, Ruiz A, Zorzato F, Treves S. Molecular basis of impaired extraocular muscle function in a mouse model of congenital myopathy due to compound heterozygous Ryr1 mutations. Human Molecular Genetics. PMID 32242214 DOI: 10.1093/Hmg/Ddaa056  0.512
2019 Eckhardt J, Bachmann C, Sekulic-Jablanovic M, Enzmann V, Park KH, Ma J, Takeshima H, Zorzato F, Treves S. Extraocular muscle function is impaired in mice. The Journal of General Physiology. PMID 31085573 DOI: 10.1085/Jgp.201912333  0.563
2019 Elbaz M, Ruiz A, Bachmann C, Eckhardt J, Pelczar P, Venturi E, Lindsay C, Wilson AD, Alhussni A, Humberstone T, Pietrangelo L, Boncompagni S, Sitsapesan R, Zorzato F. Quantitative RyR1 reduction and loss of calcium sensitivity of RyR1Q1970fsX16+A4329D cause cores and loss of muscle strength. Human Molecular Genetics. PMID 31044239 DOI: 10.1093/Hmg/Ddz092  0.488
2019 Bachmann C, Noreen F, Voermans NC, Schär PL, Vissing J, Fock JM, Bulk S, Kusters B, Moore SA, Beggs AH, Mathews KD, Meyer M, Genetti CA, Meola G, Cardani R, ... ... Zorzato F, et al. Aberrant regulation of epigenetic modifiers contributes to the pathogenesis in patients with selenoprotein N-related myopathies. Human Mutation. PMID 30932294 DOI: 10.1002/Humu.23745  0.4
2019 Elbaz M, Ruiz A, Eckhardt J, Pelczar P, Muntoni F, Boncompagni S, Treves S, Zorzato F. Quantitative reduction of RyR1 protein caused by a single-allele frameshift mutation in RYR1 ex36 impairs the strength of adult skeletal muscle fibres. Human Molecular Genetics. PMID 30689883 DOI: 10.1093/Hmg/Ddz025  0.522
2019 Bachmann C, Voermans N, Jungbluth H, Muntoni F, Zorzato F, Treves S. Biochemical and Epigenetic Modifications Occur in Muscles of Patients with Selenoprotein N Related Congenital Myopathy Biophysical Journal. 116: 153a. DOI: 10.1016/J.Bpj.2018.11.851  0.397
2019 Elbaz M, Ruiz A, Eckhardt J, Treves S, Zorzato F. Characterization of an Animal Model for Congenital Myopathies Linked to Recessive RyR1 Mutations Biophysical Journal. 116: 522a. DOI: 10.1016/J.Bpj.2018.11.2813  0.332
2018 Jungbluth H, Treves S, Zorzato F, Sarkozy A, Ochala J, Sewry C, Phadke R, Gautel M, Muntoni F. Congenital myopathies: disorders of excitation-contraction coupling and muscle contraction. Nature Reviews. Neurology. PMID 29391587 DOI: 10.1038/Nrneurol.2017.191  0.507
2018 Ruiz A, Dror E, Handschin C, Furrer R, Perez-Schindler J, Bachmann C, Treves S, Zorzato F. Over-expression of a retinol dehydrogenase (SRP35/DHRS7C) in skeletal muscle activates mTORC2, enhances glucose metabolism and muscle performance. Scientific Reports. 8: 636. PMID 29330505 DOI: 10.1038/S41598-017-18844-3  0.439
2018 Eckhardt J, Takeshima H, Nishi M, Ma J, Zorzato F, Treves S. Altered Eye Muscle Function in RYR3KO Mice Biophysical Journal. 114: 469a. DOI: 10.1016/J.Bpj.2017.11.2585  0.364
2018 Zorzato F. Characterisation of a Novel Mouse Model Carrying a Non-sense Mutation in RYR1 EX36 Biophysical Journal. 114: 469a. DOI: 10.1016/J.Bpj.2017.11.2584  0.324
2017 Eckhardt J, Sekulic-Jablanovic M, Treves S, Zorzato F. Biochemical and Mechanical Properties of Murine Extraocular Muscles Biophysical Journal. 112: 101a-102a. DOI: 10.1016/J.Bpj.2016.11.582  0.445
2017 Yang J, Reddish F, Miller C, Gorkali R, Treves S, Zorzato F. Novel Local RYR1 Junctional Calcium Responses and Dynamics by Improved Calcium Sensor Catcher Biophysical Journal. 112: 331a. DOI: 10.1016/J.Bpj.2016.11.1790  0.448
2016 Schartner V, Romero NB, Donkervoort S, Treves S, Munot P, Pierson TM, Dabaj I, Malfatti E, Zaharieva IT, Zorzato F, Abath Neto O, Brochier G, Lornage X, Eymard B, Taratuto AL, et al. Dihydropyridine receptor (DHPR, CACNA1S) congenital myopathy. Acta Neuropathologica. PMID 28012042 DOI: 10.1007/S00401-016-1656-8  0.594
2016 Bachmann C, Jungbluth H, Muntoni F, Manzur AY, Zorzato F, Treves S. Cellular, biochemical and molecular changes in muscles from patients with X-linked myotubular myopathy due to MTM1 mutations. Human Molecular Genetics. PMID 28007904 DOI: 10.1093/Hmg/Ddw388  0.551
2016 Mosca B, Eckhardt J, Bergamelli L, Treves S, Bongianino R, De Negri M, Priori SG, Protasi F, Zorzato F. Role of the JP45-calsequestrin complex on calcium entry in slow twitch skeletal muscles. The Journal of Biological Chemistry. 291: 20824. PMID 27664065 DOI: 10.1074/Jbc.A115.709071  0.464
2016 Treves S, Jungbluth H, Voermans N, Muntoni F, Zorzato F. Ca(2+) handling abnormalities in early-onset muscle diseases: novel concepts and perspectives. Seminars in Cell & Developmental Biology. PMID 27427513 DOI: 10.1016/J.Semcdb.2016.07.017  0.573
2016 Lopez RJ, Byrne S, Vukcevic M, Sekulic-Jablanovic M, Xu L, Brink M, Alamelu J, Voermans N, Snoeck M, Clement E, Muntoni F, Zhou H, Radunovic A, Mohammed S, Wraige E, ... Zorzato F, et al. An RYR1 mutation associated with malignant hyperthermia is also associated with bleeding abnormalities. Science Signaling. 9: ra68. PMID 27382027 DOI: 10.1126/scisignal.aad9813  0.434
2016 Mosca B, Eckhardt J, Bergamelli L, Treves S, Bongianino R, De Negri M, Priori SG, Protasi F, Zorzato F. Role of the JP45-calsequestrin complex on calcium entry in slow twitch skeletal muscles. The Journal of Biological Chemistry. PMID 27189940 DOI: 10.1074/Jbc.M115.709071  0.488
2016 Sekulic-Jablanovic M, Ullrich ND, Goldblum D, Palmowski-Wolfe A, Zorzato F, Treves S. Functional characterization of orbicularis oculi and extraocular muscles. The Journal of General Physiology. PMID 27069119 DOI: 10.1083/Jcb.2133Oia96  0.505
2016 Lopez R, Treves SN, Zorzato F. The Malignant Hyperthermia RYR1Y522S Mutation affects Calcium Homeostasis in Arterial Smooth Muscle Cells Biophysical Journal. 110: 98a. DOI: 10.1016/J.Bpj.2015.11.589  0.583
2015 Rokach O, Sekulic-Jablanovic M, Voermans N, Wilmshurst J, Pillay K, Heytens L, Zhou H, Muntoni F, Gautel M, Nevo Y, Mitrani-Rosenbaum S, Attali R, Finotti A, Gambari R, Mosca B, ... ... Zorzato F, et al. Epigenetic changes as a common trigger of muscle weakness in congenital myopathies. Human Molecular Genetics. 24: 4636-47. PMID 26019235 DOI: 10.1093/Hmg/Ddv195  0.505
2015 Li L, Mirza S, Richardson SJ, Gallant EM, Thekkedam C, Pace SM, Zorzato F, Liu D, Beard NA, Dulhunty AF. A new cytoplasmic interaction between junctin and ryanodine receptor Ca2+ release channels. Journal of Cell Science. 128: 951-63. PMID 25609705 DOI: 10.1242/jcs.160689  0.416
2015 Lopez RJ, Mosca B, Treves S, Maj M, Bergamelli L, Calderon JC, Bentzinger CF, Romanino K, Hall MN, Rüegg MA, Delbono O, Caputo C, Zorzato F. Raptor ablation in skeletal muscle decreases Cav1.1 expression and affects the function of the excitation-contraction coupling supramolecular complex. The Biochemical Journal. 466: 123-35. PMID 25431931 DOI: 10.1042/Bj20140935  0.514
2015 Sekulic-Jablanovic M, Palmowski-Wolfe A, Zorzato F, Treves S. Characterization of excitation-contraction coupling components in human extraocular muscles. The Biochemical Journal. 466: 29-36. PMID 25387602 DOI: 10.1042/Bj20140970  0.578
2015 Sekulic-Jablanovic M, Palmowski-Wolfe A, Zorzato F, Treves S. Excitation-Contraction Coupling in Human Extraocular Muscles:There is more than Meets the Eye Biophysical Journal. 108: 420a. DOI: 10.1016/J.Bpj.2014.11.2300  0.576
2015 Zorzato F, Mosca B, Beergamelli L, Valle G, Nori A, Treves S, Protasi F, Volpe P. Differential Role of Calsequestrin Isoforms on Calcium Entry in Skeletal Muscle FDB Fibres Biophysical Journal. 108: 269a. DOI: 10.1016/J.Bpj.2014.11.1478  0.42
2014 Mosca B, Delbono O, Messi M, Bergamelli L, Vukcevic M, Lopez R, Treves S, Nishi M, Takeshima H, Zorzato F. Role of sarcoplasmic reticulum junctional proteins in skeletal muscle strength Bmc Anesthesiology. 14: A19. DOI: 10.1186/1471-2253-14-S1-A19  0.554
2014 Lopez R, Mosca B, Bergamelli L, Ruegg MA, Bentzinger FC, Hall MN, Treves S, Zorzato F. Raptor Ablation in Skeletal Muscle Affects the Structure and Function of the Excitation-Contraction Coupling Macromolecular Complex Biophysical Journal. 106: 123a. DOI: 10.1016/J.Bpj.2013.11.733  0.506
2014 Rokach O, Ullrich ND, Rausch M, Zhou H, Muntoni F, Zorzato F, Treves S. Biochemical, Cellular and Electrophysiological Characterization of HMCL-7304 a Human Skeletal Muscle-Derived Cell Line Biophysical Journal. 106: 446a. DOI: 10.1016/J.Bpj.2013.11.2530  0.505
2013 Pérez-Schindler J, Summermatter S, Santos G, Zorzato F, Handschin C. The transcriptional coactivator PGC-1α is dispensable for chronic overload-induced skeletal muscle hypertrophy and metabolic remodeling. Proceedings of the National Academy of Sciences of the United States of America. 110: 20314-9. PMID 24277823 DOI: 10.1073/Pnas.1312039110  0.462
2013 Rokach O, Ullrich ND, Rausch M, Mouly V, Zhou H, Muntoni F, Zorzato F, Treves S. Establishment of a human skeletal muscle-derived cell line: biochemical, cellular and electrophysiological characterization. The Biochemical Journal. 455: 169-77. PMID 23905709 DOI: 10.1042/Bj20130698  0.553
2013 Vukcevic M, Zorzato F, Keck S, Tsakiris DA, Keiser J, Maizels RM, Treves S. Gain of function in the immune system caused by a ryanodine receptor 1 mutation. Journal of Cell Science. 126: 3485-92. PMID 23704352 DOI: 10.1242/Jcs.130310  0.502
2013 Mosca B, Delbono O, Laura Messi M, Bergamelli L, Wang ZM, Vukcevic M, Lopez R, Treves S, Nishi M, Takeshima H, Paolini C, Martini M, Rispoli G, Protasi F, Zorzato F. Enhanced dihydropyridine receptor calcium channel activity restores muscle strength in JP45/CASQ1 double knockout mice. Nature Communications. 4: 1541. PMID 23443569 DOI: 10.1038/Ncomms2496  0.56
2013 Yasuda T, Delbono O, Wang ZM, Messi ML, Girard T, Urwyler A, Treves S, Zorzato F. JP-45/JSRP1 variants affect skeletal muscle excitation-contraction coupling by decreasing the sensitivity of the dihydropyridine receptor. Human Mutation. 34: 184-90. PMID 22927026 DOI: 10.1002/Humu.22209  0.471
2013 Rausch M, Treves S, Zorzato F. 3D Structural Illumination Microscopy of the Skeletal Muscle Excitation-Contraction Coupling Macromolecular Complex Biophysical Journal. 104: 105a. DOI: 10.1016/J.Bpj.2012.11.615  0.35
2013 Lopez R, Vukcevic M, Zorzato F, Treves S. Physiological Role(S) of RyR1 in Smooth Muscle Cells Biophysical Journal. 104: 443a-444a. DOI: 10.1016/J.Bpj.2012.11.2461  0.587
2012 Hwang JH, Zorzato F, Clarke NF, Treves S. Mapping domains and mutations on the skeletal muscle ryanodine receptor channel. Trends in Molecular Medicine. 18: 644-57. PMID 23069638 DOI: 10.1016/J.Molmed.2012.09.006  0.576
2012 Pérez-Schindler J, Summermatter S, Salatino S, Zorzato F, Beer M, Balwierz PJ, van Nimwegen E, Feige JN, Auwerx J, Handschin C. The corepressor NCoR1 antagonizes PGC-1α and estrogen-related receptor α in the regulation of skeletal muscle function and oxidative metabolism. Molecular and Cellular Biology. 32: 4913-24. PMID 23028049 DOI: 10.1128/Mcb.00877-12  0.457
2012 Delbono O, Messi ML, Wang ZM, Treves S, Mosca B, Bergamelli L, Nishi M, Takeshima H, Shi H, Xue B, Zorzato F. Endogenously determined restriction of food intake overcomes excitation-contraction uncoupling in JP45KO mice with aging. Experimental Gerontology. 47: 304-16. PMID 22297108 DOI: 10.1016/J.Exger.2012.01.004  0.468
2012 Treves S, Thurnheer R, Mosca B, Vukcevic M, Bergamelli L, Voltan R, Oberhauser V, Ronjat M, Csernoch L, Szentesi P, Zorzato F. SRP-35, a newly identified protein of the skeletal muscle sarcoplasmic reticulum, is a retinol dehydrogenase. The Biochemical Journal. 441: 731-41. PMID 21995425 DOI: 10.1042/Bj20111457  0.542
2012 Summermatter S, Thurnheer R, Santos G, Mosca B, Baum O, Treves S, Hoppeler H, Zorzato F, Handschin C. Remodeling of calcium handling in skeletal muscle through PGC-1α: impact on force, fatigability, and fiber type. American Journal of Physiology. Cell Physiology. 302: C88-99. PMID 21918181 DOI: 10.1152/Ajpcell.00190.2011  0.454
2012 Hwang J, Amburgey K, Treves S, Zorzato F, Dowling J, Clarke N. C.P.2 In silico analysis of recessive RYR1 mutations identifies novel potential disease mechanisms Neuromuscular Disorders. 22: 841. DOI: 10.1016/J.Nmd.2012.06.130  0.373
2012 Mosca B, Bergamelli L, Vukcevic M, Treves S, Paolini C, Nishi M, Takeshima H, Protasi F, Zorzato F. Upregulation of Calcium Influx via Cav1.1 in Skeletal Muscle Fibers from JP-45 Calsequestrin 1 Double Knock Out Mice Biophysical Journal. 102: 364a. DOI: 10.1016/J.Bpj.2011.11.1986  0.427
2012 Vukcevic M, Zorzato F, Treves S. Downstream Effects of a RyR1 Mutation Linked to Malignant Hyperthermia on the Phenotypic and Functional Characteristic of Dendritic Cells Biophysical Journal. 102: 307a. DOI: 10.1016/J.Bpj.2011.11.1693  0.417
2011 Romanino K, Mazelin L, Albert V, Conjard-Duplany A, Lin S, Bentzinger CF, Handschin C, Puigserver P, Zorzato F, Schaeffer L, Gangloff YG, Rüegg MA. Myopathy caused by mammalian target of rapamycin complex 1 (mTORC1) inactivation is not reversed by restoring mitochondrial function. Proceedings of the National Academy of Sciences of the United States of America. 108: 20808-13. PMID 22143799 DOI: 10.1073/Pnas.1111448109  0.379
2011 Ullrich ND, Fischer D, Kornblum C, Walter MC, Niggli E, Zorzato F, Treves S. Alterations of excitation-contraction coupling and excitation coupled Ca(2+) entry in human myotubes carrying CAV3 mutations linked to rippling muscle. Human Mutation. 32: 309-17. PMID 21294223 DOI: 10.1002/Humu.21431  0.57
2011 Treves S, Vukcevic M, Jeannet PY, Levano S, Girard T, Urwyler A, Fischer D, Voit T, Jungbluth H, Lillis S, Muntoni F, Quinlivan R, Sarkozy A, Bushby K, Zorzato F. Enhanced excitation-coupled Ca(2+) entry induces nuclear translocation of NFAT and contributes to IL-6 release from myotubes from patients with central core disease. Human Molecular Genetics. 20: 589-600. PMID 21088110 DOI: 10.1093/Hmg/Ddq506  0.494
2010 Vukcevic M, Zorzato F, Spagnoli G, Treves S. Frequent calcium oscillations lead to NFAT activation in human immature dendritic cells. The Journal of Biological Chemistry. 285: 16003-11. PMID 20348098 DOI: 10.1074/Jbc.M109.066704  0.415
2010 Delbono O, Wang Z, Taylor J, Messi ML, Treves S, Nishi M, Takeshima H, Zorzato F. Altering Skeletal Muscle EC Coupling by Ablating the Sarcoplasmic Reticulum Protein JP45 Affects Both Metabolism and Muscle Performance in Old Mice Biophysical Journal. 98: 547a. DOI: 10.1016/J.Bpj.2009.12.2966  0.423
2010 Treves S, Griesser J, Franzini-Armstrong C, Zhu M, Zorzato F. Novel Insights into the Role of Junctate in Calcium Homeostasis: Identification of Binding Domain on the InsP3R and Cellular Localization as Determined by TIRF Microscopy Biophysical Journal. 98: 513a. DOI: 10.1016/J.Bpj.2009.12.2790  0.371
2010 Treves S, Vukcevic M, Girard T, Levano S, Urwyler A, Jeannet P, Zorzato F. Calcium Influx Analysis by TIRF Microscopy on Cultured Primary Myotubes from Patients with RyR1 Mutations Biophysical Journal. 98: 509a. DOI: 10.1016/J.Bpj.2009.12.2773  0.568
2009 Treves S, Vukcevic M, Maj M, Thurnheer R, Mosca B, Zorzato F. Minor sarcoplasmic reticulum membrane components that modulate excitation-contraction coupling in striated muscles. The Journal of Physiology. 587: 3071-9. PMID 19403606 DOI: 10.1113/Jphysiol.2009.171876  0.52
2009 Ghassemi F, Vukcevic M, Xu L, Zhou H, Meissner G, Muntoni F, Jungbluth H, Zorzato F, Treves S. A recessive ryanodine receptor 1 mutation in a CCD patient increases channel activity. Cell Calcium. 45: 192-7. PMID 19027160 DOI: 10.1016/J.Ceca.2008.10.001  0.543
2009 Treves S, Jeannet P, Vukcevic M, Girard T, Urwyler A, Zorzato F. G.P.1.08 Calcium influx analysis by TIRF microscopy on cultured primary myotubes from patients with RYR1 mutations Neuromuscular Disorders. 19: 558. DOI: 10.1016/J.Nmd.2009.06.050  0.34
2009 Vukcevic M, Spagnoli GC, Iezzi G, Zorzato F, Treves S. Ryanodine receptor 1 signaling in dendritic cells Biophysical Journal. 96: 122a. DOI: 10.1016/J.Bpj.2008.12.539  0.431
2009 Voltan R, Treves S, Ronjat M, Zorzato F. SRP-35 A Putative NAD(P)H Binding Protein Of Skeletal Muscle Sarcoplasmic Reticulum Membrane Biophysical Journal. 96: 235a. DOI: 10.1016/J.Bpj.2008.12.1154  0.439
2008 Bentzinger CF, Romanino K, Cloëtta D, Lin S, Mascarenhas JB, Oliveri F, Xia J, Casanova E, Costa CF, Brink M, Zorzato F, Hall MN, Rüegg MA. Skeletal muscle-specific ablation of raptor, but not of rictor, causes metabolic changes and results in muscle dystrophy. Cell Metabolism. 8: 411-24. PMID 19046572 DOI: 10.1016/J.Cmet.2008.10.002  0.452
2008 Vukcevic M, Spagnoli GC, Iezzi G, Zorzato F, Treves S. Ryanodine receptor activation by Ca v 1.2 is involved in dendritic cell major histocompatibility complex class II surface expression. The Journal of Biological Chemistry. 283: 34913-22. PMID 18927079 DOI: 10.1074/Jbc.M804472200  0.441
2008 Treves S, Jungbluth H, Muntoni F, Zorzato F. Congenital muscle disorders with cores: the ryanodine receptor calcium channel paradigm. Current Opinion in Pharmacology. 8: 319-26. PMID 18313359 DOI: 10.1016/J.Coph.2008.01.005  0.504
2008 Bleunven C, Treves S, Jinyu X, Leo E, Ronjat M, De Waard M, Kern G, Flucher BE, Zorzato F. SRP-27 is a novel component of the supramolecular signalling complex involved in skeletal muscle excitation-contraction coupling. The Biochemical Journal. 411: 343-9. PMID 18035970 DOI: 10.1042/Bj20070906  0.505
2007 Delbono O, Xia J, Treves S, Wang ZM, Jimenez-Moreno R, Payne AM, Messi ML, Briguet A, Schaerer F, Nishi M, Takeshima H, Zorzato F. Loss of skeletal muscle strength by ablation of the sarcoplasmic reticulum protein JP45. Proceedings of the National Academy of Sciences of the United States of America. 104: 20108-13. PMID 18077436 DOI: 10.1073/Pnas.0707389104  0.556
2007 Bracci L, Vukcevic M, Spagnoli G, Ducreux S, Zorzato F, Treves S. Ca2+ signaling through ryanodine receptor 1 enhances maturation and activation of human dendritic cells. Journal of Cell Science. 120: 2232-40. PMID 17567682 DOI: 10.1242/Jcs.007203  0.394
2007 Divet A, Paesante S, Grasso C, Cavagna D, Tiveron C, Paolini C, Protasi F, Huchet-Cadiou C, Treves S, Zorzato F. Increased Ca2+ storage capacity of the skeletal muscle sarcoplasmic reticulum of transgenic mice over-expressing membrane bound calcium binding protein junctate. Journal of Cellular Physiology. 213: 464-74. PMID 17516551 DOI: 10.1002/Jcp.21121  0.514
2007 Zorzato F, Jungbluth H, Zhou H, Muntoni F, Treves S. Functional effects of mutations identified in patients with multiminicore disease. Iubmb Life. 59: 14-20. PMID 17365175 DOI: 10.1080/15216540601187803  0.414
2007 Zhang M, Yamazaki T, Yazawa M, Treves S, Nishi M, Murai M, Shibata E, Zorzato F, Takeshima H. Calumin, a novel Ca2+-binding transmembrane protein on the endoplasmic reticulum. Cell Calcium. 42: 83-90. PMID 17204322 DOI: 10.1016/J.Ceca.2006.11.009  0.425
2007 Lyfenko AD, Ducreux S, Wang Y, Xu L, Zorzato F, Ferreiro A, Meissner G, Treves S, Dirksen RT. Two central core disease (CCD) deletions in the C-terminal region of RYR1 alter muscle excitation-contraction (EC) coupling by distinct mechanisms. Human Mutation. 28: 61-8. PMID 16958053 DOI: 10.1002/Humu.20409  0.515
2007 Zhou H, Yamaguchi N, Xu L, Wang Y, Sewry C, Jungbluth H, Zorzato F, Bertini E, Muntoni F, Meissner G, Treves S. Erratum: Characterization of recessive RYR1 mutations in core myopathies (Human Molecular Genetics (2006) vol. 15 (2791-2803) 10.1093/hmg/ddl221) Human Molecular Genetics. 16. DOI: 10.1093/Hmg/Ddm092  0.328
2006 Feriotto G, Finotti A, Breveglieri G, Treves S, Zorzato F, Gambari R. Multiple levels of control of the expression of the human A beta H-J-J locus encoding aspartyl-beta-hydroxylase, junctin, and junctate. Annals of the New York Academy of Sciences. 1091: 184-90. PMID 17341613 DOI: 10.1196/Annals.1378.065  0.309
2006 Zhou H, Yamaguchi N, Xu L, Wang Y, Sewry C, Jungbluth H, Zorzato F, Bertini E, Muntoni F, Meissner G, Treves S. Characterization of recessive RYR1 mutations in core myopathies. Human Molecular Genetics. 15: 2791-803. PMID 16940308 DOI: 10.1093/Hmg/Ddl221  0.46
2006 Pouliquin P, Pace SM, Curtis SM, Harvey PJ, Gallant EM, Zorzato F, Casarotto MG, Dulhunty AF. Effects of an alpha-helical ryanodine receptor C-terminal tail peptide on ryanodine receptor activity: modulation by Homer. The International Journal of Biochemistry & Cell Biology. 38: 1700-15. PMID 16725367 DOI: 10.1016/J.Biocel.2006.03.020  0.345
2006 Anderson AA, Altafaj X, Zheng Z, Wang ZM, Delbono O, Ronjat M, Treves S, Zorzato F. The junctional SR protein JP-45 affects the functional expression of the voltage-dependent Ca2+ channel Cav1.1. Journal of Cell Science. 119: 2145-55. PMID 16638807 DOI: 10.1242/Jcs.02935  0.437
2006 Gouadon E, Schuhmeier RP, Ursu D, Anderson AA, Treves S, Zorzato F, Lehmann-Horn F, Melzer W. A possible role of the junctional face protein JP-45 in modulating Ca2+ release in skeletal muscle. The Journal of Physiology. 572: 269-80. PMID 16423849 DOI: 10.1113/Jphysiol.2005.104406  0.491
2006 Ducreux S, Zorzato F, Ferreiro A, Jungbluth H, Muntoni F, Monnier N, Müller CR, Treves S. Functional properties of ryanodine receptors carrying three amino acid substitutions identified in patients affected by multi-minicore disease and central core disease, expressed in immortalized lymphocytes. The Biochemical Journal. 395: 259-66. PMID 16372898 DOI: 10.1042/Bj20051282  0.486
2005 Stamboulian S, Moutin MJ, Treves S, Pochon N, Grunwald D, Zorzato F, De Waard M, Ronjat M, Arnoult C. Junctate, an inositol 1,4,5-triphosphate receptor associated protein, is present in rodent sperm and binds TRPC2 and TRPC5 but not TRPC1 channels. Developmental Biology. 286: 326-37. PMID 16153633 DOI: 10.1016/J.Ydbio.2005.08.006  0.375
2005 Divet A, Paesante S, Bleunven C, Anderson A, Treves S, Zorzato F. Novel sarco(endo)plasmic reticulum proteins and calcium homeostasis in striated muscles. Journal of Muscle Research and Cell Motility. 26: 7-12. PMID 16096683 DOI: 10.1007/S10974-005-9001-1  0.527
2005 Treves S, Anderson AA, Ducreux S, Divet A, Bleunven C, Grasso C, Paesante S, Zorzato F. Ryanodine receptor 1 mutations, dysregulation of calcium homeostasis and neuromuscular disorders. Neuromuscular Disorders : Nmd. 15: 577-87. PMID 16084090 DOI: 10.1016/J.Nmd.2005.06.008  0.513
2005 Feriotto G, Finotti A, Volpe P, Treves S, Ferrari S, Angelelli C, Zorzato F, Gambari R. Myocyte enhancer factor 2 activates promoter sequences of the human AbetaH-J-J locus, encoding aspartyl-beta-hydroxylase, junctin, and junctate. Molecular and Cellular Biology. 25: 3261-75. PMID 15798210 DOI: 10.1128/Mcb.25.8.3261-3275.2005  0.393
2004 Treves S, Franzini-Armstrong C, Moccagatta L, Arnoult C, Grasso C, Schrum A, Ducreux S, Zhu MX, Mikoshiba K, Girard T, Smida-Rezgui S, Ronjat M, Zorzato F. Junctate is a key element in calcium entry induced by activation of InsP3 receptors and/or calcium store depletion. The Journal of Cell Biology. 166: 537-48. PMID 15302852 DOI: 10.1083/Jcb.200404079  0.389
2004 Ducreux S, Zorzato F, Müller C, Sewry C, Muntoni F, Quinlivan R, Restagno G, Girard T, Treves S. Effect of ryanodine receptor mutations on interleukin-6 release and intracellular calcium homeostasis in human myotubes from malignant hyperthermia-susceptible individuals and patients affected by central core disease. The Journal of Biological Chemistry. 279: 43838-46. PMID 15299003 DOI: 10.1074/jbc.M403612200  0.354
2004 Ginz HF, Zorzato F, Iaizzo PA, Urwyler A. Effect of three anaesthetic techniques on isometric skeletal muscle strength. British Journal of Anaesthesia. 92: 367-72. PMID 14742328 DOI: 10.1093/Bja/Aeh080  0.384
2003 Anderson AA, Treves S, Biral D, Betto R, Sandonà D, Ronjat M, Zorzato F. The novel skeletal muscle sarcoplasmic reticulum JP-45 protein. Molecular cloning, tissue distribution, developmental expression, and interaction with alpha 1.1 subunit of the voltage-gated calcium channel. The Journal of Biological Chemistry. 278: 39987-92. PMID 12871958 DOI: 10.1074/jbc.M305016200  0.436
2003 Zorzato F, Yamaguchi N, Xu L, Meissner G, Müller CR, Pouliquin P, Muntoni F, Sewry C, Girard T, Treves S. Clinical and functional effects of a deletion in a COOH-terminal lumenal loop of the skeletal muscle ryanodine receptor. Human Molecular Genetics. 12: 379-88. PMID 12566385 DOI: 10.1093/Hmg/Ddg032  0.482
2003 Skeie GO, Mygland A, Treves S, Gilhus NE, Aarli JA, Zorzato F. Ryanodine receptor antibodies in myasthenia gravis: epitope mapping and effect on calcium release in vitro. Muscle & Nerve. 27: 81-9. PMID 12508299 DOI: 10.1002/Mus.10294  0.431
2002 Girard T, Treves S, Censier K, Mueller CR, Zorzato F, Urwyler A. Phenotyping malignant hyperthermia susceptibility by measuring halothane-induced changes in myoplasmic calcium concentration in cultured human skeletal muscle cells. British Journal of Anaesthesia. 89: 571-9. PMID 12393358 DOI: 10.1093/Bja/Aef237  0.543
2002 Treves S, Pouliquin R, Moccagatta L, Zorzato F. Functional properties of EGFP-tagged skeletal muscle calcium-release channel (ryanodine receptor) expressed in COS-7 cells: sensitivity to caffeine and 4-chloro-m-cresol. Cell Calcium. 31: 1-12. PMID 11990295 DOI: 10.1054/ceca.2001.0252  0.348
2001 Tilgen N, Zorzato F, Halliger-Keller B, Muntoni F, Sewry C, Palmucci LM, Schneider C, Hauser E, Lehmann-Horn F, Müller CR, Treves S. Identification of four novel mutations in the C-terminal membrane spanning domain of the ryanodine receptor 1: association with central core disease and alteration of calcium homeostasis. Human Molecular Genetics. 10: 2879-87. PMID 11741831 DOI: 10.1093/Hmg/10.25.2879  0.501
2001 Girard T, Cavagna D, Padovan E, Spagnoli G, Urwyler A, Zorzato F, Treves S. B-lymphocytes from malignant hyperthermia-susceptible patients have an increased sensitivity to skeletal muscle ryanodine receptor activators. The Journal of Biological Chemistry. 276: 48077-82. PMID 11673462 DOI: 10.1074/Jbc.M107134200  0.449
2001 Girard T, Urwyler A, Censier K, Mueller CR, Zorzato F, Treves S. Genotype-phenotype comparison of the Swiss malignant hyperthermia population. Human Mutation. 18: 357-8. PMID 11668625 DOI: 10.1002/Humu.1203  0.392
2000 Zorzato F, Anderson AA, Ohlendieck K, Froemming G, Guerrini R, Treves S. Identification of a novel 45 kDa protein (JP-45) from rabbit sarcoplasmic-reticulum junctional-face membrane. The Biochemical Journal. 351: 537-43. PMID 11023841 DOI: 10.1042/Bj3510537  0.345
2000 Treves S, Feriotto G, Moccagatta L, Gambari R, Zorzato F. Molecular cloning, expression, functional characterization, chromosomal localization, and gene structure of junctate, a novel integral calcium binding protein of sarco(endo)plasmic reticulum membrane. The Journal of Biological Chemistry. 275: 39555-68. PMID 11007777 DOI: 10.1074/Jbc.M005473200  0.475
2000 Cavagna D, Zorzato F, Babini E, Prestipino G, Treves S. Methyl p-hydroxybenzoate (E-218) a preservative for drugs and food is an activator of the ryanodine receptor Ca(2+) release channel. British Journal of Pharmacology. 131: 335-41. PMID 10991928 DOI: 10.1038/Sj.Bjp.0703571  0.477
2000 Mygland A, Vincent A, Newsom-Davis J, Kaminski H, Zorzato F, Agius M, Gilhus NE, Aarli JA. Autoantibodies in thymoma-associated myasthenia gravis with myositis or neuromyotonia. Archives of Neurology. 57: 527-31. PMID 10768628 DOI: 10.1001/Archneur.57.4.527  0.317
2000 Benacquista BL, Sharma MR, Samsó M, Zorzato F, Treves S, Wagenknecht T. Amino acid residues 4425-4621 localized on the three-dimensional structure of the skeletal muscle ryanodine receptor. Biophysical Journal. 78: 1349-58. PMID 10692321 DOI: 10.1016/S0006-3495(00)76689-6  0.363
1998 Censier K, Urwyler A, Zorzato F, Treves S. Intracellular calcium homeostasis in human primary muscle cells from malignant hyperthermia-susceptible and normal individuals. Effect Of overexpression of recombinant wild-type and Arg163Cys mutated ryanodine receptors. The Journal of Clinical Investigation. 101: 1233-42. PMID 9502764 DOI: 10.1172/JCI993  0.481
1997 Zorzato F, Ronjat M, Treves S. Malignant hyperthermia domain in the regulation of ca(2+) release channel (ryanodine receptor). Trends in Cardiovascular Medicine. 7: 312-6. PMID 21235902 DOI: 10.1016/S1050-1738(97)00085-6  0.549
1997 Treves S, Scutari E, Robert M, Groh S, Ottolia M, Prestipino G, Ronjat M, Zorzato F. Interaction of S100A1 with the Ca2+ release channel (ryanodine receptor) of skeletal muscle. Biochemistry. 36: 11496-503. PMID 9298970 DOI: 10.1021/Bi970160W  0.51
1996 Zorzato F, Menegazzi P, Treves S, Ronjat M. Role of malignant hyperthermia domain in the regulation of Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum. The Journal of Biological Chemistry. 271: 22759-63. PMID 8798451 DOI: 10.1074/Jbc.271.37.22759  0.496
1996 Tegazzin V, Scutari E, Treves S, Zorzato F. Chlorocresol, an additive to commercial succinylcholine, induces contracture of human malignant hyperthermia-susceptible muscles via activation of the ryanodine receptor Ca2+ channel. Anesthesiology. 84: 1380-5. PMID 8669679 DOI: 10.1097/00000542-199606000-00014  0.56
1995 Guerrini R, Menegazzi P, Anacardio R, Marastoni M, Tomatis R, Zorzato F, Treves S. Calmodulin binding sites of the skeletal, cardiac, and brain ryanodine receptor Ca2+ channels: modulation by the catalytic subunit of cAMP-dependent protein kinase? Biochemistry. 34: 5120-9. PMID 7711031 DOI: 10.1021/Bi00015A024  0.352
1995 Buratti R, Prestipino G, Menegazzi P, Treves S, Zorzato F. Calcium dependent activation of skeletal muscle Ca2+ release channel (ryanodine receptor) by calmodulin. Biochemical and Biophysical Research Communications. 213: 1082-90. PMID 7544580 DOI: 10.1006/bbrc.1995.2238  0.397
1995 Larini F, Menegazzi P, Baricordi O, Zorzato F, Treves S. A ryanodine receptor-like Ca2+ channel is expressed in nonexcitable cells. Molecular Pharmacology. 47: 21-8. PMID 7530806  0.372
1994 Treves S, Larini F, Menegazzi P, Steinberg TH, Koval M, Vilsen B, Andersen JP, Zorzato F. Alteration of intracellular Ca2+ transients in COS-7 cells transfected with the cDNA encoding skeletal-muscle ryanodine receptor carrying a mutation associated with malignant hyperthermia. The Biochemical Journal. 301: 661-5. PMID 8053891  0.492
1994 Menegazzi P, Larini F, Treves S, Guerrini R, Quadroni M, Zorzato F. Identification and characterization of three calmodulin binding sites of the skeletal muscle ryanodine receptor. Biochemistry. 33: 9078-84. PMID 8049209 DOI: 10.1021/Bi00197A008  0.465
1994 Zorzato F, Sacchetto R, Margreth A. Identification of two ryanodine receptor transcripts in neonatal, slow-, and fast-twitch rabbit skeletal muscles. Biochemical and Biophysical Research Communications. 203: 1725-30. PMID 7945321 DOI: 10.1006/bbrc.1994.2385  0.398
1993 Zorzato F, Scutari E, Tegazzin V, Clementi E, Treves S. Chlorocresol: an activator of ryanodine receptor-mediated Ca2+ release. Molecular Pharmacology. 44: 1192-201. PMID 8264556  0.381
1993 Treves S, Chiozzi P, Zorzato F. Identification of the domain recognized by anti-(ryanodine receptor) antibodies which affect Ca(2+)-induced Ca2+ release. The Biochemical Journal. 291: 757-63. PMID 7683874  0.38
1992 Treves S, Vilsen B, Chiozzi P, Andersen JP, Zorzato F. Molecular cloning, functional expression and tissue distribution of the cDNA encoding frog skeletal muscle calsequestrin. The Biochemical Journal. 283: 767-72. PMID 1375450  0.395
1992 MacLennan DH, Otsu K, Fujii J, Zorzato F, Phillips MS, O'Brien PJ, Archibald AL, Britt BA, Gillard EF, Worton RG. The role of the skeletal muscle ryanodine receptor gene in malignant hyperthermia. Symposia of the Society For Experimental Biology. 46: 189-201. PMID 1341035  0.614
1991 Trevesø S, Zorzato F, Chiozzi P, Melandri P, Volpe P, Pozzan T. Frog brain expresses a 60 KDa Ca2+ binding protein similar to mammalian calreticulin. Biochemical and Biophysical Research Communications. 175: 444-50. PMID 2018493 DOI: 10.1016/0006-291X(91)91584-Y  0.393
1991 Fujii J, Otsu K, Zorzato F, de Leon S, Khanna VK, Weiler JE, O'Brien PJ, MacLennan DH. Identification of a mutation in porcine ryanodine receptor associated with malignant hyperthermia. Science (New York, N.Y.). 253: 448-51. PMID 1862346 DOI: 10.1126/Science.1862346  0.607
1991 Fill M, Mejia-Alvarez R, Zorzato F, Volpe P, Stefani E. Antibodies as probes for ligand gating of single sarcoplasmic reticulum Ca2(+)-release channels. The Biochemical Journal. 273: 449-57. PMID 1703762 DOI: 10.1042/Bj2730449  0.401
1990 Otsu K, Willard HF, Khanna VK, Zorzato F, Green NM, MacLennan DH. Molecular cloning of cDNA encoding the Ca2+ release channel (ryanodine receptor) of rabbit cardiac muscle sarcoplasmic reticulum. The Journal of Biological Chemistry. 265: 13472-83. PMID 2380170  0.628
1990 Zorzato F, Fujii J, Otsu K, Phillips M, Green NM, Lai FA, Meissner G, MacLennan DH. Molecular cloning of cDNA encoding human and rabbit forms of the Ca2+ release channel (ryanodine receptor) of skeletal muscle sarcoplasmic reticulum. The Journal of Biological Chemistry. 265: 2244-56. PMID 2298749  0.54
1990 MacLennan DH, Duff C, Zorzato F, Fujii J, Phillips M, Korneluk RG, Frodis W, Britt BA, Worton RG. Ryanodine receptor gene is a candidate for predisposition to malignant hyperthermia. Nature. 343: 559-61. PMID 1967823 DOI: 10.1038/343559A0  0.639
1989 Zorzato F, Chu A, Volpe P. Antibodies to junctional sarcoplasmic reticulum proteins: probes for the Ca2+-release channel. The Biochemical Journal. 261: 863-70. PMID 2552993 DOI: 10.1042/Bj2610863  0.44
1989 Zorzato F, Volpe P, Damiani E, Quaglino D, Margreth A. Terminal cisternae of denervated rabbit skeletal muscle: alterations of functional properties of Ca2+ release channels. The American Journal of Physiology. 257: C504-11. PMID 2551173 DOI: 10.1152/Ajpcell.1989.257.3.C504  0.542
1988 Zorzato F, Volpe P. Calcium binding proteins of junctional sarcoplasmic reticulum: detection by 45Ca ligand overlay. Archives of Biochemistry and Biophysics. 261: 324-9. PMID 3355154 DOI: 10.1016/0003-9861(88)90347-5  0.406
1988 Volpe P, Krause KH, Hashimoto S, Zorzato F, Pozzan T, Meldolesi J, Lew DP. "Calciosome," a cytoplasmic organelle: the inositol 1,4,5-trisphosphate-sensitive Ca2+ store of nonmuscle cells? Proceedings of the National Academy of Sciences of the United States of America. 85: 1091-5. PMID 3257572 DOI: 10.1073/Pnas.85.4.1091  0.484
1988 Pozzan T, Volpe P, Zorzato F, Bravin M, Krause KH, Lew DP, Hashimoto S, Bruno B, Meldolesi J. The Ins(1,4,5)P3-sensitive Ca2+ store of non-muscle cells: endoplasmic reticulum or calciosomes? The Journal of Experimental Biology. 139: 181-93. PMID 3062119  0.361
1988 Salvatori S, Damiani E, Zorzato F, Volpe P, Pierobon S, Quaglino D, Salviati G, Margreth A. Denervation-induced proliferative changes of triads in rabbit skeletal muscle. Muscle & Nerve. 11: 1246-59. PMID 2976894 DOI: 10.1002/Mus.880111209  0.539
1988 Volpe P, Bravin M, Zorzato F, Margreth A. Isolation of terminal cisternae of frog skeletal muscle. Calcium storage and release properties. The Journal of Biological Chemistry. 263: 9901-7. PMID 2968342  0.406
1988 Pozzan T, Volpe P, Zorzato F, Bravin M, Lew DP, Krause KH, Hashimoto S, Bruno B, Meldolesi J. Immunocytological identification of the microsomal calcium store of nonmuscle cells. Journal of Cardiovascular Pharmacology. 12: S80-4. PMID 2469883 DOI: 10.1097/00005344-198800125-00014  0.465
1987 Volpe P, Zorzato F, Pozzan T, Salviati G, Di Virgilio F. Measurement of calcium release from sarcoplasmic reticulum of skeletal muscle: effect of calcium and inositol 1,4,5-trisphosphate. Methods in Enzymology. 141: 3-18. PMID 3298965 DOI: 10.1016/0076-6879(87)41051-3  0.44
1986 Damiani E, Salvatori S, Zorzato F, Margreth A. Characteristics of skeletal muscle calsequestrin: comparison of mammalian, amphibian and avian muscles. Journal of Muscle Research and Cell Motility. 7: 435-45. PMID 3491835 DOI: 10.1007/Bf01753586  0.412
1986 Zorzato F, Margreth A, Volpe P. Direct photoaffinity labeling of junctional sarcoplasmic reticulum with [14C]doxorubicin. The Journal of Biological Chemistry. 261: 13252-7. PMID 2428816  0.321
1985 Zorzato F, Salviati G, Facchinetti T, Volpe P. Doxorubicin induces calcium release from terminal cisternae of skeletal muscle. A study on isolated sarcoplasmic reticulum and chemically skinned fibers. The Journal of Biological Chemistry. 260: 7349-55. PMID 2581966  0.387
1985 Zorzato F, Volpe P, Salviati G, Margreth A. Ca2+ channel agonist BAY-k 8644 does not elicit Ca2+ release from skeletal muscle sarcoplasmic reticulum. Febs Letters. 186: 255-8. PMID 2408924 DOI: 10.1016/0014-5793(85)80719-5  0.463
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