Carlos T. Moraes - Publications

Neuroscience (Medicine) University of Miami, Coral Gables, FL 
Neuroscience Biology, Molecular Biology, Aging

187 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Peralta S, Pinto M, Arguello T, Garcia S, Diaz F, Moraes CT. Metformin delays neurological symptom onset in a mouse model of neuronal complex I deficiency. Jci Insight. 5. PMID 33148885 DOI: 10.1172/jci.insight.141183  0.68
2020 Bacman SR, Gammage PA, Minczuk M, Moraes CT. Manipulation of mitochondrial genes and mtDNA heteroplasmy. Methods in Cell Biology. 155: 441-487. PMID 32183972 DOI: 10.1016/Bs.Mcb.2019.12.004  0.32
2020 Bacman SR, Nissanka N, Moraes CT. Cybrid technology. Methods in Cell Biology. 155: 415-439. PMID 32183971 DOI: 10.1016/bs.mcb.2019.11.025  0.32
2020 Zekonyte U, Bacman SR, Moraes CT. DNA Editing Enzymes as Potential Treatments for Heteroplasmic mtDNA Diseases. Journal of Internal Medicine. PMID 32176378 DOI: 10.1111/Joim.13055  0.32
2018 Bacman SR, Kauppila JHK, Pereira CV, Nissanka N, Miranda M, Pinto M, Williams SL, Larsson NG, Stewart JB, Moraes CT. Author Correction: MitoTALEN reduces mutant mtDNA load and restores tRNA levels in a mouse model of heteroplasmic mtDNA mutation. Nature Medicine. PMID 30291358 DOI: 10.1038/S41591-018-0234-0  0.68
2018 Bacman SR, Kauppila JHK, Pereira CV, Nissanka N, Miranda M, Pinto M, Williams SL, Larsson NG, Stewart JB, Moraes CT. MitoTALEN reduces mutant mtDNA load and restores tRNA levels in a mouse model of heteroplasmic mtDNA mutation. Nature Medicine. PMID 30250143 DOI: 10.1038/S41591-018-0166-8  0.68
2018 Pinto M, Vempati UD, Diaz F, Peralta S, Moraes CT. Ablation of Cytochrome c in Adult Forebrain Neurons Impairs Oxidative Phosphorylation Without Detectable Apoptosis. Molecular Neurobiology. PMID 30191381 DOI: 10.1007/S12035-018-1335-Y  0.68
2018 Pereira CV, Bacman SR, Arguello T, Zekonyte U, Williams SL, Edgell DR, Moraes CT. mitoTev-TALE: a monomeric DNA editing enzyme to reduce mutant mitochondrial DNA levels. Embo Molecular Medicine. PMID 30012581 DOI: 10.15252/Emmm.201708084  0.36
2018 Nissanka N, Bacman SR, Plastini MJ, Moraes CT. The mitochondrial DNA polymerase gamma degrades linear DNA fragments precluding the formation of deletions. Nature Communications. 9: 2491. PMID 29950568 DOI: 10.1038/S41467-018-04895-1  0.32
2018 Rebelo AP, Saade D, Pereira CP, Farooq A, Huff TC, Abreu L, Moraes CT, Mnatsakanova D, Mathews K, Yang H, Schon EA, Zuchner S, Shy ME. SCO2 mutations cause early-onset axonal Charcot-Marie-Tooth disease associated with cellular copper deficiency. Brain : a Journal of Neurology. PMID 29351582 DOI: 10.1093/Brain/Awx369  0.72
2017 Pinto M, Nissanka N, Moraes CT. Lack of Parkin anticipates the phenotype and affects mitochondrial morphology and mtDNA levels in a mouse model of Parkinson's Disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29222404 DOI: 10.1523/Jneurosci.1384-17.2017  0.68
2017 Madsen PM, Pinto M, Patel S, McCarthy S, Gao H, Taherian M, Karmally S, Pereira CV, Dvoriantchikova G, Ivanov D, Tanaka KF, Moraes CT, Brambilla R. Mitochondrial DNA double-strand breaks in oligodendrocytes cause demyelination, axonal injury and CNS inflammation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28931570 DOI: 10.1523/Jneurosci.1378-17.2017  0.68
2016 Wenz T, Diaz F, Spiegelman BM, Moraes CT. Retraction Notice to: Activation of the PPAR/PGC-1α Pathway Prevents a Bioenergetic Deficit and Effectively Improves a Mitochondrial Myopathy Phenotype. Cell Metabolism. 24: 889. PMID 27974182 DOI: 10.1016/J.Cmet.2016.11.006  0.48
2016 Pinto M, Pickrell AM, Wang X, Bacman SR, Yu A, Hida A, Dillon LM, Morton PD, Malek TR, Williams SL, Moraes CT. Transient mitochondrial DNA double strand breaks in mice cause accelerated aging phenotypes in a ROS-dependent but p53/p21-independent manner. Cell Death and Differentiation. PMID 27911443 DOI: 10.1038/Cdd.2016.123  0.96
2016 Luo X, Ribeiro M, Bray ER, Lee DH, Yungher BJ, Mehta ST, Thakor KA, Diaz F, Lee JK, Moraes CT, Bixby JL, Lemmon VP, Park KK. Enhanced Transcriptional Activity and Mitochondrial Localization of STAT3 Co-induce Axon Regrowth in the Adult Central Nervous System. Cell Reports. PMID 27050520 DOI: 10.1016/J.Celrep.2016.03.029  1
2016 Pinto M, Nissanka N, Peralta S, Brambilla R, Diaz F, Moraes CT. Pioglitazone ameliorates the phenotype of a novel Parkinson's disease mouse model by reducing neuroinflammation. Molecular Neurodegeneration. 11: 25. PMID 27038906 DOI: 10.1186/S13024-016-0090-7  1
2015 Arguello T, Moraes CT. Cre recombinase activity is inhibited in vivo but not ex vivo by a mutation in the asymmetric spacer region of the distal loxP site. Genesis (New York, N.Y. : 2000). 53: 695-700. PMID 26331883 DOI: 10.1002/Dvg.22899  1
2015 Hashimoto M, Bacman SR, Peralta S, Falk MJ, Chomyn A, Chan DC, Williams SL, Moraes CT. MitoTALEN: A General Approach to Reduce Mutant mtDNA Loads and Restore Oxidative Phosphorylation Function in Mitochondrial Diseases. Molecular Therapy : the Journal of the American Society of Gene Therapy. PMID 26159306 DOI: 10.1038/Mt.2015.126  1
2015 Pinto M, Moraes CT. Mechanisms linking mtDNA damage and aging. Free Radical Biology & Medicine. 85: 250-8. PMID 25979659 DOI: 10.1016/J.Freeradbiomed.2015.05.005  1
2015 Reddy P, Ocampo A, Suzuki K, Luo J, Bacman SR, Williams SL, Sugawara A, Okamura D, Tsunekawa Y, Wu J, Lam D, Xiong X, Montserrat N, Esteban CR, Liu GH, ... ... Moraes CT, et al. Selective elimination of mitochondrial mutations in the germline by genome editing. Cell. 161: 459-69. PMID 25910206 DOI: 10.1016/J.Cell.2015.03.051  1
2014 Bacman SR, Williams SL, Pinto M, Moraes CT. The use of mitochondria-targeted endonucleases to manipulate mtDNA. Methods in Enzymology. 547: 373-97. PMID 25416366 DOI: 10.1016/B978-0-12-801415-8.00018-7  1
2014 Moraes CT, Bacman SR, Williams SL. Manipulating mitochondrial genomes in the clinic: playing by different rules. Trends in Cell Biology. 24: 209-11. PMID 24679453 DOI: 10.1016/J.Tcb.2014.02.002  1
2014 Moraes CT. A magic bullet to specifically eliminate mutated mitochondrial genomes from patients' cells. Embo Molecular Medicine. 6: 434-5. PMID 24623377 DOI: 10.1002/Emmm.201303769  1
2014 De Rocco D, Cerqua C, Goffrini P, Russo G, Pastore A, Meloni F, Nicchia E, Moraes CT, Pecci A, Salviati L, Savoia A. Mutations of cytochrome c identified in patients with thrombocytopenia THC4 affect both apoptosis and cellular bioenergetics. Biochimica Et Biophysica Acta. 1842: 269-74. PMID 24326104 DOI: 10.1016/J.Bbadis.2013.12.002  1
2014 Pinto M, Moraes CT. Mitochondrial genome changes and neurodegenerative diseases. Biochimica Et Biophysica Acta. 1842: 1198-207. PMID 24252612 DOI: 10.1016/J.Bbadis.2013.11.012  1
2014 Peralta S, Torraco A, Wenz T, Garcia S, Diaz F, Moraes CT. Partial complex I deficiency due to the CNS conditional ablation of Ndufa5 results in a mild chronic encephalopathy but no increase in oxidative damage. Human Molecular Genetics. 23: 1399-412. PMID 24154540 DOI: 10.1093/Hmg/Ddt526  1
2013 Williams SL, Mash DC, Züchner S, Moraes CT. Somatic mtDNA mutation spectra in the aging human putamen. Plos Genetics. 9: e1003990. PMID 24339796 DOI: 10.1371/Journal.Pgen.1003990  1
2013 Pohjoismäki JL, Williams SL, Boettger T, Goffart S, Kim J, Suomalainen A, Moraes CT, Braun T. Overexpression of Twinkle-helicase protects cardiomyocytes from genotoxic stress caused by reactive oxygen species. Proceedings of the National Academy of Sciences of the United States of America. 110: 19408-13. PMID 24218554 DOI: 10.1073/Pnas.1303046110  1
2013 Moraes CT, Anderson V, Mohan C. Translational research in primary mitochondrial diseases: challenges and opportunities. Mitochondrion. 13: 945-52. PMID 23962609 DOI: 10.1016/J.Mito.2013.08.002  1
2013 Bacman SR, Williams SL, Pinto M, Peralta S, Moraes CT. Specific elimination of mutant mitochondrial genomes in patient-derived cells by mitoTALENs. Nature Medicine. 19: 1111-3. PMID 23913125 DOI: 10.1038/Nm.3261  1
2013 Wang X, Peralta S, Moraes CT. Mitochondrial alterations during carcinogenesis: a review of metabolic transformation and targets for anticancer treatments. Advances in Cancer Research. 119: 127-60. PMID 23870511 DOI: 10.1016/B978-0-12-407190-2.00004-6  1
2013 Moraes CT. Adrenoleukodystrophy and the mitochondrial connection: clues for supplementing Lorenzo's oil. Brain : a Journal of Neurology. 136: 2339-41. PMID 23842565 DOI: 10.1093/Brain/Awt189  1
2013 Wang X, Pickrell AM, Rossi SG, Pinto M, Dillon LM, Hida A, Rotundo RL, Moraes CT. Transient systemic mtDNA damage leads to muscle wasting by reducing the satellite cell pool. Human Molecular Genetics. 22: 3976-86. PMID 23760083 DOI: 10.1093/Hmg/Ddt251  1
2013 Pinto M, Pickrell AM, Fukui H, Moraes CT. Mitochondrial DNA damage in a mouse model of Alzheimer's disease decreases amyloid beta plaque formation. Neurobiology of Aging. 34: 2399-407. PMID 23702344 DOI: 10.1016/J.Neurobiolaging.2013.04.014  1
2013 Noe N, Dillon L, Lellek V, Diaz F, Hida A, Moraes CT, Wenz T. Bezafibrate improves mitochondrial function in the CNS of a mouse model of mitochondrial encephalopathy. Mitochondrion. 13: 417-26. PMID 23261681 DOI: 10.1016/J.Mito.2012.12.003  1
2013 Pickrell AM, Pinto M, Moraes CT. Mouse models of Parkinson's disease associated with mitochondrial dysfunction. Molecular and Cellular Neurosciences. 55: 87-94. PMID 22954895 DOI: 10.1016/J.Mcn.2012.08.002  1
2012 Gamba J, Gamba LT, Rodrigues GS, Kiyomoto BH, Moraes CT, Tengan CH. Nitric oxide synthesis is increased in cybrid cells with m.3243A>G mutation. International Journal of Molecular Sciences. 14: 394-410. PMID 23263669 DOI: 10.3390/Ijms14010394  1
2012 Pinto M, Pickrell AM, Moraes CT. Regional susceptibilities to mitochondrial dysfunctions in the CNS. Biological Chemistry. 393: 275-81. PMID 23029655 DOI: 10.1515/Hsz-2011-0236  1
2012 Dillon LM, Hida A, Garcia S, Prolla TA, Moraes CT. Long-term bezafibrate treatment improves skin and spleen phenotypes of the mtDNA mutator mouse. Plos One. 7: e44335. PMID 22962610 DOI: 10.1371/Journal.Pone.0044335  1
2012 Diaz F, Garcia S, Padgett KR, Moraes CT. A defect in the mitochondrial complex III, but not complex IV, triggers early ROS-dependent damage in defined brain regions. Human Molecular Genetics. 21: 5066-77. PMID 22914734 DOI: 10.1093/Hmg/Dds350  1
2012 White MG, Saleh O, Nonner D, Barrett EF, Moraes CT, Barrett JN. Mitochondrial dysfunction induced by heat stress in cultured rat CNS neurons. Journal of Neurophysiology. 108: 2203-14. PMID 22832569 DOI: 10.1152/Jn.00638.2011  1
2012 Fünfschilling U, Supplie LM, Mahad D, Boretius S, Saab AS, Edgar J, Brinkmann BG, Kassmann CM, Tzvetanova ID, Möbius W, Diaz F, Meijer D, Suter U, Hamprecht B, Sereda MW, ... Moraes CT, et al. Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity. Nature. 485: 517-21. PMID 22622581 DOI: 10.1038/Nature11007  1
2012 Wang X, Pickrell AM, Zimmers TA, Moraes CT. Increase in muscle mitochondrial biogenesis does not prevent muscle loss but increased tumor size in a mouse model of acute cancer-induced cachexia. Plos One. 7: e33426. PMID 22428048 DOI: 10.1371/Journal.Pone.0033426  1
2012 Dillon LM, Williams SL, Hida A, Peacock JD, Prolla TA, Lincoln J, Moraes CT. Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse. Human Molecular Genetics. 21: 2288-97. PMID 22357654 DOI: 10.1093/Hmg/Dds049  1
2012 Dillon LM, Rebelo AP, Moraes CT. The role of PGC-1 coactivators in aging skeletal muscle and heart. Iubmb Life. 64: 231-41. PMID 22279035 DOI: 10.1002/Iub.608  1
2012 Bacman SR, Williams SL, Duan D, Moraes CT. Manipulation of mtDNA heteroplasmy in all striated muscles of newborn mice by AAV9-mediated delivery of a mitochondria-targeted restriction endonuclease. Gene Therapy. 19: 1101-6. PMID 22130448 DOI: 10.1038/Gt.2011.196  1
2012 Peralta S, Wang X, Moraes CT. Mitochondrial transcription: lessons from mouse models. Biochimica Et Biophysica Acta. 1819: 961-9. PMID 22120174 DOI: 10.1016/J.Bbagrm.2011.11.001  1
2012 Diaz F, Enríquez JA, Moraes CT. Cells lacking Rieske iron-sulfur protein have a reactive oxygen species-associated decrease in respiratory complexes I and IV. Molecular and Cellular Biology. 32: 415-29. PMID 22106410 DOI: 10.1128/Mcb.06051-11  1
2011 Pickrell AM, Pinto M, Hida A, Moraes CT. Striatal dysfunctions associated with mitochondrial DNA damage in dopaminergic neurons in a mouse model of Parkinson's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 17649-58. PMID 22131425 DOI: 10.1523/Jneurosci.4871-11.2011  1
2011 Wang X, Moraes CT. Increases in mitochondrial biogenesis impair carcinogenesis at multiple levels. Molecular Oncology. 5: 399-409. PMID 21855427 DOI: 10.1016/J.Molonc.2011.07.008  1
2011 Pickrell AM, Fukui H, Wang X, Pinto M, Moraes CT. The striatum is highly susceptible to mitochondrial oxidative phosphorylation dysfunctions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9895-904. PMID 21734281 DOI: 10.1523/Jneurosci.6223-10.2011  1
2011 Diaz F, Kotarsky H, Fellman V, Moraes CT. Mitochondrial disorders caused by mutations in respiratory chain assembly factors. Seminars in Fetal & Neonatal Medicine. 16: 197-204. PMID 21680271 DOI: 10.1016/J.Siny.2011.05.004  1
2011 Rebelo AP, Dillon LM, Moraes CT. Mitochondrial DNA transcription regulation and nucleoid organization. Journal of Inherited Metabolic Disease. 34: 941-51. PMID 21541724 DOI: 10.1007/S10545-011-9330-8  1
2011 Wenz T, Wang X, Marini M, Moraes CT. A metabolic shift induced by a PPAR panagonist markedly reduces the effects of pathogenic mitochondrial tRNA mutations. Journal of Cellular and Molecular Medicine. 15: 2317-25. PMID 21129152 DOI: 10.1111/J.1582-4934.2010.01223.X  1
2010 Williams SL, Huang J, Edwards YJ, Ulloa RH, Dillon LM, Prolla TA, Vance JM, Moraes CT, Züchner S. The mtDNA mutation spectrum of the progeroid Polg mutator mouse includes abundant control region multimers. Cell Metabolism. 12: 675-82. PMID 21109200 DOI: 10.1016/J.Cmet.2010.11.012  1
2010 Wenz T, Williams SL, Bacman SR, Moraes CT. Emerging therapeutic approaches to mitochondrial diseases. Developmental Disabilities Research Reviews. 16: 219-29. PMID 20818736 DOI: 10.1002/Ddrr.109  1
2010 Pickrell AM, Moraes CT. What role does mitochondrial stress play in neurodegenerative diseases? Methods in Molecular Biology (Clifton, N.J.). 648: 63-78. PMID 20700705 DOI: 10.1007/978-1-60761-756-3_4  1
2010 Bacman SR, Williams SL, Garcia S, Moraes CT. Organ-specific shifts in mtDNA heteroplasmy following systemic delivery of a mitochondria-targeted restriction endonuclease. Gene Therapy. 17: 713-20. PMID 20220783 DOI: 10.1016/J.Mito.2011.03.055  1
2009 Moraes CT. Making the most of what you've got: optimizing residual OXPHOS function in mitochondrial diseases. Embo Molecular Medicine. 1: 357-9. PMID 20049740 DOI: 10.1002/Emmm.200900049  1
2009 Wenz T, Rossi SG, Rotundo RL, Spiegelman BM, Moraes CT. Increased muscle PGC-1alpha expression protects from sarcopenia and metabolic disease during aging. Proceedings of the National Academy of Sciences of the United States of America. 106: 20405-10. PMID 19918075 DOI: 10.1073/Pnas.0911570106  1
2009 Pickrell AM, Fukui H, Moraes CT. The role of cytochrome c oxidase deficiency in ROS and amyloid plaque formation. Journal of Bioenergetics and Biomembranes. 41: 453-6. PMID 19795195 DOI: 10.1007/S10863-009-9245-3  1
2009 Rebelo AP, Williams SL, Moraes CT. In vivo methylation of mtDNA reveals the dynamics of protein-mtDNA interactions. Nucleic Acids Research. 37: 6701-15. PMID 19740762 DOI: 10.1093/Nar/Gkp727  1
2009 Wenz T, Luca C, Torraco A, Moraes CT. mTERF2 regulates oxidative phosphorylation by modulating mtDNA transcription. Cell Metabolism. 9: 499-511. PMID 19490905 DOI: 10.1016/J.Cmet.2009.04.010  1
2009 Bacman SR, Williams SL, Moraes CT. Intra- and inter-molecular recombination of mitochondrial DNA after in vivo induction of multiple double-strand breaks. Nucleic Acids Research. 37: 4218-26. PMID 19435881 DOI: 10.1093/Nar/Gkp348  1
2009 Srivastava S, Diaz F, Iommarini L, Aure K, Lombes A, Moraes CT. PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders. Human Molecular Genetics. 18: 1805-12. PMID 19297390 DOI: 10.1093/Hmg/Ddp093  1
2009 Wenz T, Diaz F, Hernandez D, Moraes CT. Endurance exercise is protective for mice with mitochondrial myopathy. Journal of Applied Physiology (Bethesda, Md. : 1985). 106: 1712-9. PMID 19286571 DOI: 10.1152/Japplphysiol.91571.2008  1
2009 Fukui H, Moraes CT. Mechanisms of formation and accumulation of mitochondrial DNA deletions in aging neurons. Human Molecular Genetics. 18: 1028-36. PMID 19095717 DOI: 10.1093/Hmg/Ddn437  1
2009 Vempati UD, Han X, Moraes CT. Lack of cytochrome c in mouse fibroblasts disrupts assembly/stability of respiratory complexes I and IV. The Journal of Biological Chemistry. 284: 4383-91. PMID 19075019 DOI: 10.1074/Jbc.M805972200  1
2009 Torraco A, Diaz F, Vempati UD, Moraes CT. Mouse models of oxidative phosphorylation defects: powerful tools to study the pathobiology of mitochondrial diseases. Biochimica Et Biophysica Acta. 1793: 171-80. PMID 18601959 DOI: 10.1016/J.Bbamcr.2008.06.003  1
2009 Srivastava S, Moraes CT. Cellular adaptations to oxidative phosphorylation defects in cancer Cellular Respiration and Carcinogenesis. 55-72. DOI: 10.1007/978-1-59745-435-3_5  1
2008 Vempati UD, Torraco A, Moraes CT. Mouse models of oxidative phosphorylation dysfunction and disease. Methods (San Diego, Calif.). 46: 241-7. PMID 18848991 DOI: 10.1016/J.Ymeth.2008.09.008  1
2008 Wenz T, Diaz F, Spiegelman BM, Moraes CT. Activation of the PPAR/PGC-1alpha pathway prevents a bioenergetic deficit and effectively improves a mitochondrial myopathy phenotype. Cell Metabolism. 8: 249-56. PMID 18762025 DOI: 10.1016/J.Cmet.2008.07.006  1
2008 Fukui H, Moraes CT. The mitochondrial impairment, oxidative stress and neurodegeneration connection: reality or just an attractive hypothesis? Trends in Neurosciences. 31: 251-6. PMID 18403030 DOI: 10.1016/J.Tins.2008.02.008  1
2008 Garcia S, Diaz F, Moraes CT. A 3' UTR modification of the mitochondrial rieske iron sulfur protein in mice produces a specific skin pigmentation phenotype. The Journal of Investigative Dermatology. 128: 2343-5. PMID 18401429 DOI: 10.1038/Jid.2008.64  1
2008 Diaz F, Moraes CT. Mitochondrial biogenesis and turnover. Cell Calcium. 44: 24-35. PMID 18395251 DOI: 10.1016/J.Ceca.2007.12.004  1
2008 van Waveren C, Moraes CT. Transcriptional co-expression and co-regulation of genes coding for components of the oxidative phosphorylation system. Bmc Genomics. 9: 18. PMID 18194548 DOI: 10.1186/1471-2164-9-18  1
2008 Diaz F, Garcia S, Hernandez D, Regev A, Rebelo A, Oca-Cossio J, Moraes CT. Pathophysiology and fate of hepatocytes in a mouse model of mitochondrial hepatopathies. Gut. 57: 232-42. PMID 17951359 DOI: 10.1136/Gut.2006.119180  1
2008 Bamne MN, Talkowski ME, Moraes CT, Manuck SB, Ferrell RE, Chowdari KV, Nimgaonkar VL. Systematic association studies of mitochondrial DNA variations in schizophrenia: focus on the ND5 gene. Schizophrenia Bulletin. 34: 458-65. PMID 17898419 DOI: 10.1093/Schbul/Sbm100  1
2007 Fukui H, Diaz F, Garcia S, Moraes CT. Cytochrome c oxidase deficiency in neurons decreases both oxidative stress and amyloid formation in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 104: 14163-8. PMID 17715058 DOI: 10.1073/Pnas.0705738104  1
2007 Bacman SR, Williams SL, Hernandez D, Moraes CT. Modulating mtDNA heteroplasmy by mitochondria-targeted restriction endonucleases in a 'differential multiple cleavage-site' model. Gene Therapy. 14: 1309-18. PMID 17597792 DOI: 10.1038/Sj.Gt.3302981  1
2007 Bell EL, Klimova TA, Eisenbart J, Moraes CT, Murphy MP, Budinger GR, Chandel NS. The Qo site of the mitochondrial complex III is required for the transduction of hypoxic signaling via reactive oxygen species production. The Journal of Cell Biology. 177: 1029-36. PMID 17562787 DOI: 10.1083/Jcb.200609074  1
2007 Bacman SR, Moraes CT. Transmitochondrial technology in animal cells. Methods in Cell Biology. 80: 503-24. PMID 17445711 DOI: 10.1016/S0091-679X(06)80025-7  1
2007 Williams SL, Moraes CT. Microdissection and analytical PCR for the investigation of mtDNA lesions. Methods in Cell Biology. 80: 481-501. PMID 17445710 DOI: 10.1016/S0091-679X(06)80024-5  1
2007 Fukui H, Moraes CT. Extended polyglutamine repeats trigger a feedback loop involving the mitochondrial complex III, the proteasome and huntingtin aggregates. Human Molecular Genetics. 16: 783-97. PMID 17356014 DOI: 10.1093/Hmg/Ddm023  1
2007 Srivastava S, Barrett JN, Moraes CT. PGC-1alpha/beta upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations. Human Molecular Genetics. 16: 993-1005. PMID 17341490 DOI: 10.1093/Hmg/Ddm045  1
2007 Vempati UD, Diaz F, Barrientos A, Narisawa S, Mian AM, Millán JL, Boise LH, Moraes CT. Role of cytochrome C in apoptosis: increased sensitivity to tumor necrosis factor alpha is associated with respiratory defects but not with lack of cytochrome C release. Molecular and Cellular Biology. 27: 1771-83. PMID 17210651 DOI: 10.1128/Mcb.00287-06  1
2007 Brunelle JK, Shroff EH, Perlman H, Strasser A, Moraes CT, Flavell RA, Danial NN, Keith B, Thompson CB, Chandel NS. Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death. Molecular and Cellular Biology. 27: 1222-35. PMID 17145774 DOI: 10.1128/Mcb.01535-06  1
2006 Meany DL, Poe BG, Navratil M, Moraes CT, Arriaga EA. Superoxide released into the mitochondrial matrix. Free Radical Biology & Medicine. 41: 950-9. PMID 16934678 DOI: 10.1016/J.Freeradbiomed.2006.06.003  1
2006 Diaz F, Fukui H, Garcia S, Moraes CT. Cytochrome c oxidase is required for the assembly/stability of respiratory complex I in mouse fibroblasts. Molecular and Cellular Biology. 26: 4872-81. PMID 16782876 DOI: 10.1128/Mcb.01767-05  1
2006 Bacman SR, Bradley WG, Moraes CT. Mitochondrial involvement in amyotrophic lateral sclerosis: trigger or target? Molecular Neurobiology. 33: 113-31. PMID 16603792 DOI: 10.1385/Mn:33:2:113  1
2006 van Waveren C, Sun Y, Cheung HS, Moraes CT. Oxidative phosphorylation dysfunction modulates expression of extracellular matrix--remodeling genes and invasion. Carcinogenesis. 27: 409-18. PMID 16221732 DOI: 10.1093/Carcin/Bgi242  1
2005 Bayona-Bafaluy MP, Blits B, Battersby BJ, Shoubridge EA, Moraes CT. Rapid directional shift of mitochondrial DNA heteroplasmy in animal tissues by a mitochondrially targeted restriction endonuclease. Proceedings of the National Academy of Sciences of the United States of America. 102: 14392-7. PMID 16179392 DOI: 10.1073/Pnas.0502896102  1
2005 Diaz F, Thomas CK, Garcia S, Hernandez D, Moraes CT. Mice lacking COX10 in skeletal muscle recapitulate the phenotype of progressive mitochondrial myopathies associated with cytochrome c oxidase deficiency. Human Molecular Genetics. 14: 2737-48. PMID 16103131 DOI: 10.1093/Hmg/Ddi307  1
2005 Srivastava S, Moraes CT. Double-strand breaks of mouse muscle mtDNA promote large deletions similar to multiple mtDNA deletions in humans. Human Molecular Genetics. 14: 893-902. PMID 15703189 DOI: 10.1093/Hmg/Ddi082  1
2005 Dave KR, Raval AP, Purroy J, Kirkinezos IG, Moraes CT, Bradley WG, Pérez-Pinzón MA. Aberrant deltaPKC activation in the spinal cord of Wobbler mouse: a model of motor neuron disease. Neurobiology of Disease. 18: 126-33. PMID 15649703 DOI: 10.1016/J.Nbd.2004.08.017  1
2005 Kirkinezos IG, Bacman SR, Hernandez D, Oca-Cossio J, Arias LJ, Perez-Pinzon MA, Bradley WG, Moraes CT. Cytochrome c association with the inner mitochondrial membrane is impaired in the CNS of G93A-SOD1 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 164-72. PMID 15634778 DOI: 10.1523/Jneurosci.3829-04.2005  1
2005 Bayona-Bafaluy MP, Müller S, Moraes CT. Fast adaptive coevolution of nuclear and mitochondrial subunits of ATP synthetase in orangutan. Molecular Biology and Evolution. 22: 716-24. PMID 15574809 DOI: 10.1093/Molbev/Msi059  1
2004 Luca CC, Lam BL, Moraes CT. Erythromycin as a potential precipitating agent in the onset of Leber's hereditary optic neuropathy. Mitochondrion. 4: 31-6. PMID 16120371 DOI: 10.1016/J.Mito.2004.05.002  1
2004 Moraes CT, Diaz F, Barrientos A. Defects in the biosynthesis of mitochondrial heme c and heme a in yeast and mammals. Biochimica Et Biophysica Acta. 1659: 153-9. PMID 15576047 DOI: 10.1016/J.Bbabio.2004.09.002  1
2004 D'Aurelio M, Gajewski CD, Lin MT, Mauck WM, Shao LZ, Lenaz G, Moraes CT, Manfredi G. Heterologous mitochondrial DNA recombination in human cells. Human Molecular Genetics. 13: 3171-9. PMID 15496432 DOI: 10.1093/Hmg/Ddh326  1
2004 Acín-Pérez R, Bayona-Bafaluy MP, Fernández-Silva P, Moreno-Loshuertos R, Pérez-Martos A, Bruno C, Moraes CT, Enríquez JA. Respiratory complex III is required to maintain complex I in mammalian mitochondria. Molecular Cell. 13: 805-15. PMID 15053874 DOI: 10.1016/S1097-2765(04)00124-8  1
2004 Kirkinezos IG, Hernandez D, Bradley WG, Moraes CT. An ALS mouse model with a permeable blood-brain barrier benefits from systemic cyclosporine A treatment. Journal of Neurochemistry. 88: 821-6. PMID 14756802 DOI: 10.1046/J.1471-4159.2003.02181.X  1
2003 Moraes CT, Atencio DP, Oca-Cossio J, Diaz F. Techniques and pitfalls in the detection of pathogenic mitochondrial DNA mutations. The Journal of Molecular Diagnostics : Jmd. 5: 197-208. PMID 14573777 DOI: 10.1016/S1525-1578(10)60474-6  1
2003 Oca-Cossio J, Kenyon L, Hao H, Moraes CT. Limitations of allotopic expression of mitochondrial genes in mammalian cells. Genetics. 165: 707-20. PMID 14573482  1
2003 Kirkinezos IG, Hernandez D, Bradley WG, Moraes CT. Regular exercise is beneficial to a mouse model of amyotrophic lateral sclerosis. Annals of Neurology. 53: 804-7. PMID 12783429 DOI: 10.1002/Ana.10597  1
2003 Bacman SR, Atencio DP, Moraes CT. Decreased mitochondrial tRNALys steady-state levels and aminoacylation are associated with the pathogenic G8313A mitochondrial DNA mutation. The Biochemical Journal. 374: 131-6. PMID 12737626 DOI: 10.1042/Bj20030222  1
2003 Manfredi G, Kwong JQ, Oca-Cossio JA, Woischnik M, Gajewski CD, Martushova K, D'Aurelio M, Friedlich AL, Moraes CT. BCL-2 improves oxidative phosphorylation and modulates adenine nucleotide translocation in mitochondria of cells harboring mutant mtDNA. The Journal of Biological Chemistry. 278: 5639-45. PMID 12431997 DOI: 10.1074/Jbc.M203080200  1
2002 Moraes CT, Srivastava S, Kirkinezos I, Oca-Cossio J, van Waveren C, Woischnick M, Diaz F. Mitochondrial DNA structure and function. International Review of Neurobiology. 53: 3-23. PMID 12512335 DOI: 10.1016/S0074-7742(02)53002-6  1
2002 Diaz F, Bayona-Bafaluy MP, Rana M, Mora M, Hao H, Moraes CT. Human mitochondrial DNA with large deletions repopulates organelles faster than full-length genomes under relaxed copy number control. Nucleic Acids Research. 30: 4626-33. PMID 12409452 DOI: 10.1093/Nar/Gkf602  1
2002 Moraes CT. Studying mitochondria of animal cells. Methods (San Diego, Calif.). 26: 291. PMID 12054918 DOI: 10.1016/S1046-2023(02)00033-6  1
2002 Woischnik M, Moraes CT. Pattern of organization of human mitochondrial pseudogenes in the nuclear genome. Genome Research. 12: 885-93. PMID 12045142 DOI: 10.1101/Gr.227202  1
2001 Srivastava S, Moraes CT. Manipulating mitochondrial DNA heteroplasmy by a mitochondrially targeted restriction endonuclease. Human Molecular Genetics. 10: 3093-9. PMID 11751691 DOI: 10.1093/Hmg/10.26.3093  1
2001 Kirkinezos IG, Moraes CT. Reactive oxygen species and mitochondrial diseases. Seminars in Cell & Developmental Biology. 12: 449-57. PMID 11735379 DOI: 10.1006/Scdb.2001.0282  1
2001 Moraes CT. A helicase is born Nature Genetics. 28: 200-201. PMID 11431681 DOI: 10.1038/90020  1
2001 Moraes CT, Dey R, Barrientos A. Transmitochondrial technology in animal cells. Methods in Cell Biology. 65: 397-412. PMID 11381606  1
2001 Moraes CT. What regulates mitochondrial DNA copy number in animal cells? Trends in Genetics. 17: 199-205. PMID 11275325 DOI: 10.1016/S0168-9525(01)02238-7  1
2001 Xu GP, Dave KR, Moraes CT, Busto R, Sick TJ, Bradley WG, Pérez-Pinzón MA. Dysfunctional mitochondrial respiration in the wobbler mouse brain. Neuroscience Letters. 300: 141-4. PMID 11226631 DOI: 10.1016/S0304-3940(01)01575-0  1
2000 Lanza RP, Cibelli JB, Diaz F, Moraes CT, Farin PW, Farin CE, Hammer CJ, West MD, Damiani P. Cloning of an endangered species (Bos gaurus) using interspecies nuclear transfer. Cloning. 2: 79-90. PMID 16218862 DOI: 10.1089/152045500436104  1
2000 Hu YP, Moraes CT, Savaraj N, Priebe W, Lampidis TJ. ρ0 Tumor cells: A model for studying whether mitochondria are targets for rhodamine 123, doxorubicin, and other drugs Biochemical Pharmacology. 60: 1897-1905. PMID 11108806 DOI: 10.1016/S0006-2952(00)00513-X  1
2000 Rana M, De Coo I, Diaz F, Smeets H, Moraes CT. An out-of-frame cytochrome b gene deletion from a patient with parkinsonism is associated with impaired complex III assembly and an increase in free radical production Annals of Neurology. 48: 774-781. PMID 11079541 DOI: 10.1002/1531-8249(200011)48:5<774::Aid-Ana11>3.0.Co;2-I  1
2000 Barrientos A, Müller S, Dey R, Wienberg J, Moraes CT. Cytochrome c oxidase assembly in primates is sensitive to small evolutionary variations in amino acid sequence. Molecular Biology and Evolution. 17: 1508-19. PMID 11018157 DOI: 10.1093/Oxfordjournals.Molbev.A026250  1
2000 Dey R, Tengan CH, Morita MPA, Kiyomoto BH, Moraes CT. A novel myopathy-associated mitochondrial DNA mutation altering the conserved size of the tRNA(Gln) anticodon loop Neuromuscular Disorders. 10: 488-492. PMID 10996779 DOI: 10.1016/S0960-8966(00)00125-5  1
2000 Dey R, Barrientos A, Moraes CT. Functional constraints of nuclear-mitochondrial DNA interactions in xenomitochondrial rodent cell lines. The Journal of Biological Chemistry. 275: 31520-7. PMID 10908562 DOI: 10.1074/Jbc.M004053200  1
2000 Jarreta D, Orús J, Barrientos A, Miró O, Roig E, Heras M, Moraes CT, Cardellach F, Casademont J. Mitochondrial function in heart muscle from patients with idiopathic dilated cardiomyopathy. Cardiovascular Research. 45: 860-5. PMID 10728411 DOI: 10.1016/S0008-6363(99)00388-0  1
2000 Dey R, Moraes CT. Lack of oxidative phosphorylation and low mitochondrial membrane potential decrease susceptibility to apoptosis and do not modulate the protective effect of Bcl-x(L) in osteosarcoma cells Journal of Biological Chemistry. 275: 7087-7094. PMID 10702275 DOI: 10.1074/Jbc.275.10.7087  1
1999 Chen L, Segal DM, Moraes CT, Mash DC. Dopamine transporter mRNA in autopsy studies of chronic cocaine users Molecular Brain Research. 73: 181-185. PMID 10581411 DOI: 10.1016/S0169-328X(99)00233-8  1
1999 Moraes CT, Kenyon L, Hao H. Mechanisms of human mitochondrial DNA maintenance: The determining role of primary sequence and length over function Molecular Biology of the Cell. 10: 3345-3356. PMID 10512871 DOI: 10.1091/Mbc.10.10.3345  1
1999 Barrientos A, Moraes CT. Titrating the effects of mitochondrial complex I impairment in the cell physiology. The Journal of Biological Chemistry. 274: 16188-97. PMID 10347173 DOI: 10.1074/Jbc.274.23.16188  1
1999 Hao H, Morrison LE, Moraes CT. Suppression of a mitochondrial tRNA gene mutation phenotype associated with changes in the nuclear background Human Molecular Genetics. 8: 1117-1124. PMID 10332045 DOI: 10.1093/Hmg/8.6.1117  1
1998 Zeviani M, Moraes CT, DiMauro S, Nakase H, Bonilla E, Schon EA, Rowland LP. Deletions of mitochondrial DNA in Kearns-Sayre syndrome. 1988. Neurology. 51: 1525 and 8 pages fol. PMID 9855494 DOI: 10.1212/WNL.51.6.1525-A  1
1998 Barrientos A, Moraes CT. Simultaneous transfer of mitochondrial DNA and single chromosomes in somatic cells: a novel approach for the study of defects in nuclear-mitochondrial communication. Human Molecular Genetics. 7: 1801-8. PMID 9736783 DOI: 10.1093/Hmg/7.11.1801  1
1998 Schon EA, Shoubridge EA, Moraes CT, Swerdlow RH, Parker WD. Cybrids in Alzheimer's disease: A cellular model of the disease? [3] (multiple letters) Neurology. 51: 326-327. PMID 9674844 DOI: 10.1212/WNL.51.1.326  1
1998 Barrientos A, Kenyon L, Moraes CT. Human xenomitochondrial cybrids. Cellular models of mitochondrial complex I deficiency. The Journal of Biological Chemistry. 273: 14210-7. PMID 9603924 DOI: 10.1074/Jbc.273.23.14210  1
1998 Tengan CH, Moraes CT. Duplication and triplication with staggered breakpoints in human mitochondrial DNA Biochimica Et Biophysica Acta - Molecular Basis of Disease. 1406: 73-80. PMID 9545538 DOI: 10.1016/S0925-4439(97)00087-2  1
1998 Tengan CH, Kiyomoto BH, Rocha MS, Tavares VL, Gabbai AA, Moraes CT. Mitochondrial encephalomyopathy and hypoparathyroidism associated with a duplication and a deletion of mitochondrial deoxyribonucleic acid. The Journal of Clinical Endocrinology and Metabolism. 83: 125-9. PMID 9435428 DOI: 10.1210/Jcem.83.1.4497  1
1997 Kiyomoto BH, Tengan CH, Moraes CT, Oliveira ASB, Gabbai AA. Mitochondrial DNA defects in Brazilian patients with chronic progressive external ophthalmoplegia Journal of the Neurological Sciences. 152: 160-165. PMID 9415537 DOI: 10.1016/S0022-510X(97)00158-5  1
1997 Verma A, Piccoli DA, Bonilla E, Berry GT, DiMauro S, Moraes CT. A novel mitochondrial G8313A mutation associated with prominent initial gastrointestinal symptoms and progressive encephaloneuropathy Pediatric Research. 42: 448-454. PMID 9380435 DOI: 10.1203/00006450-199710000-00005  1
1997 Hao H, Moraes CT. A disease-associated G5703A mutation in human mitochondrial DNA causes a conformational change and a marked decrease in steady-state levels of mitochondrial tRNA(Asn) Molecular and Cellular Biology. 17: 6831-6837. PMID 9372914 DOI: 10.1128/Mcb.17.12.6831  1
1997 Tengan CH, Gabbai AA, Shanske S, Zeviani M, Moraes CT. Oxidative phosphorylation dysfunction does not increase the rate of accumulation of age-related mtDNA deletions in skeletal muscle Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 379: 1-11. PMID 9330617 DOI: 10.1016/S0027-5107(97)00076-6  1
1997 Kenyon L, Moraes CT. Expanding the functional human mitochondrial DNA database by the establishment of primate xenomitochondrial cybrids Proceedings of the National Academy of Sciences of the United States of America. 94: 9131-9135. PMID 9256447 DOI: 10.1073/Pnas.94.17.9131  1
1997 Hao H, Manfredi G, Moraes CT. Functional and structural features of a tandem duplication of the human mtDNA promoter region American Journal of Human Genetics. 60: 1363-1372. PMID 9199557 DOI: 10.1086/515474  1
1997 Segal DM, Moraes CT, Mash DC. Up-regulation of D3 dopamine receptor mRNA in the nucleus accumbens of human cocaine fatalities Molecular Brain Research. 45: 335-339. PMID 9149110 DOI: 10.1016/S0169-328X(97)00025-9  1
1996 Moraes CT, Schon EA. [44] Detection and analysis of mitochondrial DNA and RNA in muscle by in situ hybridization and single-fiber PCR Methods in Enzymology. 264: 522-536. PMID 8965724 DOI: 10.1016/S0076-6879(96)64046-4  1
1996 Manfredi G, Schon EA, Bonilla E, Moraes CT, Shanske S, DiMauro S. Identification of a mutation in the mitochondrial tRNACys gene associated with mitochondrial encephalopathy Human Mutation. 7: 158-163. PMID 8829635 DOI: 10.1002/(Sici)1098-1004(1996)7:2<158::Aid-Humu12>3.0.Co;2-1  1
1996 Tengan CH, Moraes CT. Detection and analysis of mitochondrial DNA deletions by whole genome PCR Biochemical and Molecular Medicine. 58: 130-134. PMID 8809354 DOI: 10.1006/Bmme.1996.0040  1
1996 Verma A, Moraes CT, Shebert RT, Bradley WG. A MERRF/PEO overlap syndrome associated with the mitochondrial DNA 3243 mutation. Neurology. 46: 1334-6. PMID 8628477 DOI: 10.1212/Wnl.46.5.1334  1
1996 Hao H, Moraes CT. Functional and molecular mitochondrial abnormalities associated with a C → T transition at position 3256 of the human mitochondrial genome: The effects of a pathogenic mitochondrial tRNA point mutation in organelle translation and RNA processing Journal of Biological Chemistry. 271: 2347-2352. PMID 8567699 DOI: 10.1074/Jbc.271.4.2347  1
1995 Hao H, Bonilla E, Manfredi G, DiMauro S, Moraes CT. Segregation patterns of a novel mutation in the mitochondrial tRNA glutamic acid gene associated with myopathy and diabetes mellitus American Journal of Human Genetics. 56: 1017-1025. PMID 7726154  1
1995 Manfredi G, Servidei S, Bonilla E, Shanske S, Schon EA, Dimauro S, Moraes CT. High levels of mitochondrial dna with an unstable 260-bp duplication in a patient with a mitochondrial myopathy Neurology. 45: 762-768. PMID 7723967 DOI: 10.1212/Wnl.45.4.762  1
1995 Moraes CT, Sciacco M, Ricci E, Tengan CH, Hao H, Bonilla E, Schon EA, DiMauro S. Phenotype-genotype correlations in skeletal muscle of patients with mtDNA deletions Muscle and Nerve. 18. PMID 7603517 DOI: 10.1002/Mus.880181429  1
1995 Manfredi G, Schon EA, Moraes CT, Bonilla E, Berry GT, Sladky JT, Dimauro S. A new mutation associated with MELAS is located in a mitochondrial DNA polypeptide-coding gene Neuromuscular Disorders. 5: 391-398. PMID 7496173 DOI: 10.1016/0960-8966(94)00079-O  1
1995 Petruzzella V, Hirano M, Moraes CT, Dimauro S, Bonilla E, Schon EA. Phenotypical expression and molecular genetics of the nt-3243 mutation in the mitochondrial tRNA(LEU(UUR)) gene Bulletin of Molecular Biology and Medicine. 20: 177-183.  1
1994 Ionasescu VV, Hart M, DiMauro S, Moraes CT. Clinical and morphologic features of a myopathy associated with a point mutation in the mitochondrial tRNAPro gene Neurology. 44: 975-977. PMID 8190311 DOI: 10.1212/Wnl.44.5.975  1
1994 Sciacco M, Bonilla E, Schon EA, Dimauro S, Moraes CT. Distribution of wild-type and common deletion forms of mtDNA in normal and respiration-deficient muscle fibers from patients with mitochondrial myopathy Human Molecular Genetics. 3: 13-19. PMID 8162014 DOI: 10.1093/Hmg/3.1.13  1
1994 Petruzzella V, Moraes CT, Sano MC, Bonilla SE, Dimauro S, Schon EA. Extremely high levels of mutant mtDNAs co-localize with cytocohrome c oxidase-negative ragged-red fibers in patients harboring a point mutation at nt 3243 Human Molecular Genetics. 3: 449-454. PMID 7912129 DOI: 10.1093/Hmg/3.3.449  1
1993 DiMauro S, Simonetti S, Chen X, Petruzzella V, Hirano M, Shanske S, Moraes CT, Schon EA. Mitochondrial dysfunction as a mechanism of CNS injury Research Publications - Association For Research in Nervous and Mental Disease. 71: 67-79. PMID 8417473  1
1993 Moraes CT, Ciacci F, Silvestri G, Shanske S, Sciacco M, Hirano M, Schon EA, Bonilla E, DiMauro S. Atypical clinical presentations associated with the MELAS mutation at position 3243 of human mitochondrial DNA Neuromuscular Disorders. 3: 43-50. PMID 8392410 DOI: 10.1016/0960-8966(93)90040-Q  1
1993 Moraes CT, Ciacci F, Bonilla E, Jansen C, Hirano M, Rao N, Lovelace RE, Rowland LP, Schon EA, DiMauro S. Two novel pathogenic mitochondrial DNA mutations affecting organelle number and protein synthesis. Is the tRNA(Leu(UUR)) gene an etiologic hot spot? The Journal of Clinical Investigation. 92: 2906-15. PMID 8254046 DOI: 10.1172/Jci116913  1
1993 Dimauro S, Moraes CT. Mitochondrial Encephalomyopathies Archives of Neurology. 50: 1197-1208. PMID 8215979 DOI: 10.1001/archneur.1993.00540110075008  1
1993 Moraes CT, Ciacci F, Bonilla E, Ionasescu V, Schon EA, Dimauro S. A mitochondrial tRNA anticodon swap associated with a muscle disease Nature Genetics. 4: 284-288. PMID 7689388 DOI: 10.1038/Ng0793-284  1
1993 Moraes CT. Mitochondrial DNA depletion in human pathology International Pediatrics. 8: 40-44.  1
1992 Tritschler HJ, Andreetta F, Moraes CT, Bonilla E, Arnaudo E, Danon MJ, Glass S, Zelaya BM, Vamos E, Telerman-Toppet N. Mitochondrial myopathy of childhood associated with depletion of mitochondrial DNA. Neurology. 42: 209-17. PMID 1734306 DOI: 10.1212/Wnl.42.1.209  1
1992 Ciafaloni E, Ricci E, Shanske S, Moraes CT, Silvestri G, Hirano M, Simonetti S, Angelini C, Donati MA, Garcia C, Martinuzzi A, Mosewich R, Servidei S, Zammarchi E, Bonilla E, et al. MELAS: Clinical features, biochemistry, and molecular genetics Annals of Neurology. 31: 391-398. PMID 1586140 DOI: 10.1002/Ana.410310408  1
1992 Schon EA, Koga Y, Davidson M, Moraes CT, King MP. The mitochondrial tRNA(Leu)(UUR)) mutation in MELAS: a model for pathogenesis. Biochimica Et Biophysica Acta. 1101: 206-9. PMID 1378759  1
1992 Sancho S, Moraes CT, Tanji K, Miranda AF. Structural and functional mitochondrial abnormalities associated with high levels of partially deleted mitochondrial DNAs in somatic cell hybrids. Somatic Cell and Molecular Genetics. 18: 431-42. PMID 1362009 DOI: 10.1007/Bf01233083  1
1992 Silvestri G, Moraes CT, Shanske S, Oh SJ, DiMauro S. A new mtDNA mutation in the tRNALys gene associated with myoclonic epilepsy and ragged-red fibers (MERRF) American Journal of Human Genetics. 51: 1213-1217. PMID 1361099  1
1992 Ricci E, Moraes CT, Servidei S, Tonali P, Bonilla E, DiMauro S. Disorders associated with depletion of mitochondrial DNA Brain Pathology. 2: 141-147. PMID 1341955 DOI: 10.1111/J.1750-3639.1992.Tb00682.X  1
1992 Bonilla E, Sciacco M, Tanji K, Sparaco M, Petruzzella V, Moraes CT. New morphological approaches to the study of mitochondrial encephalomyopathies. Brain Pathology (Zurich, Switzerland). 2: 113-9. PMID 1341952 DOI: 10.1111/J.1750-3639.1992.Tb00679.X  1
1992 Moraes CT, Ricci E, Bonilla E, DiMauro S, Schon EA. The mitochondrial tRNALeu(UUR) mutation in mitochondrial encephalomyopathy, lactic acidosis, and strokelike episodes (MELAS): Genetic, biochemical, and morphological correlations in skeletal muscle American Journal of Human Genetics. 50: 934-949. PMID 1315123  1
1992 Moraes CT, Ricci E, Petruzzella V, Shanske S, DiMauro S, Schon EA, Bonilla E. Molecular analysis of the muscle pathology associated with mitochondrial DNA deletions Nature Genetics. 1: 359-367. PMID 1284549 DOI: 10.1038/Ng0892-359  1
1991 Moraes CT, Shanske S, Tritschler HJ, Aprille JR, Andreetta F, Bonilla E, Schon EA, DiMauro S. mtDNA depletion with variable tissue expression: a novel genetic abnormality in mitochondrial diseases. American Journal of Human Genetics. 48: 492-501. PMID 1998336  1
1991 Moraes CT, Andreetta F, Bonilla E, Shanske S, DiMauro S, Schon EA. Replication-competent human mitochondrial DNA lacking the heavy-strand promoter region Molecular and Cellular Biology. 11: 1631-1637. PMID 1996112 DOI: 10.1128/Mcb.11.3.1631  1
1991 Zupanc ML, Moraes CT, Shanske S, Langman CB, Ciafaloni E, DiMauro S. Deletion of mitochondrial DNA in patients with combined features of Kearns-Sayre and MELAS syndromes Annals of Neurology. 29: 680-683. PMID 1892371 DOI: 10.1002/Ana.410290619  1
1991 Moraes CT, Zeviani M, Schon EA, Hickman RO, Vlcek BW, DiMauro S. Mitochondrial DNA deletion in a girl with manifestations of Kearns-Sayre and Lowe syndromes: An example of phenotypic mimicry? American Journal of Medical Genetics. 41: 301-305. PMID 1789283 DOI: 10.1002/Ajmg.1320410308  1
1991 Arnaudo E, Shanske S, DiMauro S, Schon EA, Moraes CT, Dalakas M. Depletion of muscle mitochondrial DNA in AIDS patients with zidovudine-induced myopathy The Lancet. 337: 508-510. PMID 1671889 DOI: 10.1016/0140-6736(91)91294-5  1
1991 Dimauro S, Moraes CT, Shanske S, Lombes A, Nakase H, Mita S, Tritschler HJ, Bonilla E, Miranda AF, Schon EA. Mitochondrial encephalomyopathies: biochemical approach. Revue Neurologique. 147: 443-9. PMID 1660180  1
1990 Mita S, Rizzuto R, Moraes CT, Shanske S, Arnaudo E, Fabrizi GM, Koga Y, Dimauro S, Schon EA. Recombination via flanking direct repeats is a major cause of large-scale deletions of human mitochondrial DNA Nucleic Acids Research. 18: 561-567. PMID 2308845 DOI: 10.1093/Nar/18.3.561  1
1990 Shanske S, Moraes CT, Lombes A, Miranda AF, Bonilla E, Lewis P, Whelan MA, Ellsworth CA, Dimauro S. Widespread tissue distribution of mitochondrial dna deletions in kearns-sayre syndrome Neurology. 40: 24-28. PMID 2296377 DOI: 10.1212/Wnl.40.1.24  1
1990 Nakase H, Moraes CT, Rizzuto R, Lombes A, DiMauro S, Schon EA. Transcription and translation of deleted mitochondrial genomes in Kearns-Sayre syndrome: Implications for pathogenesis American Journal of Human Genetics. 46: 418-427. PMID 1689952  1
1990 Shanske S, Moraes CT, DiMauro S. Reply: mtDNA deletions in kearns-sayre Neurology. 40: 1322.  1
1990 Moraes CT, DiMauro S, Shanske S, Rowland LP. Mitochondrial DNA deletions and ophthalmoplegia (I: Reply) New England Journal of Medicine. 322: 701.  1
1989 Schon EA, Bonilla E, Lombes A, Moraes CT, Nakase H, Rizzuto R, Zeviani M, DiMauro S. Clinical and biochemical studies on cytochrome oxidase deficiencies Annals of the New York Academy of Sciences. 550: 348-359. PMID 2854407 DOI: 10.1111/J.1749-6632.1988.Tb35349.X  1
1989 Schon EA, Rizzuto R, Moraes CT, Nakase H, Zeviani M, DiMauro S. A direct repeat is a hotspot for large-scale deletion of human mitochondrial DNA Science. 244: 346-349. PMID 2711184 DOI: 10.1126/Science.2711184  1
1989 Moraes CT, Schon EA, DiMauro S, Miranda AF. Heteroplasmy of mitochondrial genomes in clonal cultures from patients with Kearns-Sayre syndrome Biochemical and Biophysical Research Communications. 160: 765-771. PMID 2541710 DOI: 10.1016/0006-291X(89)92499-6  1
1989 Moraes CT, DiMauro S, Zeviani M, Lombes A, Shanske S, Miranda AF, Nakase H, Bonilla E, Werneck LC, Servidei S, Nonaka I, Koga Y, Spiro AJ, Brownell AKW, Schmidt B, et al. Mitochondrial DNA deletions in progressive external ophthalmoplegia and Kearne-Sayre syndrome New England Journal of Medicine. 320: 1293-1299. PMID 2541333 DOI: 10.1056/Nejm198905183202001  1
1988 Zeviani M, Moraes CT, DiMauro S, Nakase H, Bonilla E, Schon EA, Rowland LP. Deletions of mitochondrial DNA in Kearns-Sayre syndrome. Neurology. 38: 1339-46. PMID 3412580 DOI: 10.1212/Wnl.38.9.1339  1
1988 Miranda AF, Bonilla E, Martucci G, Moraes CT, Hays AP, Dimauro S. Immunocytochemical study of dystrophin in muscle cultures from patients with Duchenne muscular dystrophy and unaffected control patients. The American Journal of Pathology. 132: 410-6. PMID 3046367  1
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