Kent E. Vrana - Publications

Pharmacology Pennsylvania State University, State College, PA, United States 
biogenic amines, stem cells, dopamine, drug abuse, alcoholism, tyrosine hydroxylase, tryptophan hydroxylase, parthenogenesis,

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Year Citation  Score
2020 Douton JE, Augusto C, Stoltzfus B, Carkaci-Salli N, Vrana KE, Grigson PS. Glucagon-like peptide-1 receptor agonist, exendin-4, reduces reinstatement of heroin-seeking behavior in rats. Behavioural Pharmacology. PMID 33229892 DOI: 10.1097/FBP.0000000000000609  0.32
2019 Coates MD, Kim JS, Carkaci-Salli N, Vrana KE, Koltun WA, Puhl HL, Adhikary SD, Janicki PK, Ruiz-Velasco V. Impact of the Na1.8 variant, A1073V, on post-sigmoidectomy pain and electrophysiological function in rat sympathetic neurons. Journal of Neurophysiology. PMID 31642403 DOI: 10.1152/jn.00542.2019  0.32
2018 Imperio CG, McFalls AJ, Hadad N, Blanco-Berdugo L, Masser DR, Colechio EM, Coffey AA, Bixler GV, Stanford DR, Vrana KE, Grigson PS, Freeman WM. Exposure to environmental enrichment attenuates addiction-like behavior and alters molecular effects of heroin self-administration in rats. Neuropharmacology. PMID 29964093 DOI: 10.1016/j.neuropharm.2018.06.037  0.6
2017 Coates MD, Tekin I, Vrana KE, Mawe GM. Review article: the many potential roles of intestinal serotonin (5-hydroxytryptamine, 5-HT) signalling in inflammatory bowel disease. Alimentary Pharmacology & Therapeutics. PMID 28737264 DOI: 10.1111/apt.14226  0.32
2015 Tekin I, Vgontzas A, Lewis MM, Kothari S, Kong L, Lu Y, Vrana KE, Huang X. Previous Injury and Chronic Pain are Associated with Side of Onset in Parkinson's Disease. Journal of Neurology and Neurobiology. 1. PMID 26937489  0.32
2015 Imperio CG, McFalls AJ, Colechio EM, Masser DR, Vrana KE, Grigson PS, Freeman WM. Assessment of individual differences in the rat nucleus accumbens transcriptome following taste-heroin extended access. Brain Research Bulletin. PMID 26733446 DOI: 10.1016/j.brainresbull.2015.12.005  1
2015 Tekin I, Carkaci-Salli N, Lewis MM, Mailman RB, Huang X, Vrana KE. The V81M variant of tyrosine hydroxylase is associated with more severe freezing of gait in Parkinson's disease. Parkinsonism & Related Disorders. PMID 26732803 DOI: 10.1016/j.parkreldis.2015.12.015  1
2015 McFalls AJ, Imperio CG, Bixler G, Freeman WM, Grigson PS, Vrana KE. Reward devaluation and heroin escalation is associated with differential expression of CRF signaling genes. Brain Research Bulletin. PMID 26655889 DOI: 10.1016/j.brainresbull.2015.11.009  1
2015 Merelo V, Durand D, Lescallette AR, Vrana KE, Hong LE, Faghihi MA, Bellon A. Associating schizophrenia, long non-coding RNAs and neurostructural dynamics. Frontiers in Molecular Neuroscience. 8: 57. PMID 26483630 DOI: 10.3389/fnmol.2015.00057  1
2015 Shapiro D, Vrana K. Opinion: Celebrating R and D expenditures badly misses the point. Proceedings of the National Academy of Sciences of the United States of America. 112: 9496-7. PMID 26243873 DOI: 10.1073/pnas.1509005112  1
2014 Sathyendra V, Donahue HJ, Vrana KE, Berg A, Fryzel D, Gandhi J, Reid JS. Single Nucleotide Polymorphisms in Osteogenic Genes in Atrophic Delayed Fracture-Healing: A Preliminary Investigation. The Journal of Bone and Joint Surgery. American Volume. 96: 1242-1248. PMID 25100770 DOI: 10.2106/JBJS.M.00453  1
2014 Carkaci-Salli N, Salli U, Tekin I, Hengst JA, Zhao MK, Gilman TL, Andrews AM, Vrana KE. Functional characterization of the S41Y (C2755A) polymorphism of tryptophan hydroxylase 2. Journal of Neurochemistry. 130: 748-58. PMID 24899127 DOI: 10.1111/jnc.12779  1
2014 Tekin I, Roskoski R, Carkaci-Salli N, Vrana KE. Complex molecular regulation of tyrosine hydroxylase. Journal of Neural Transmission (Vienna, Austria : 1996). 121: 1451-81. PMID 24866693 DOI: 10.1007/s00702-014-1238-7  1
2013 Tekin I, Vrana KE. Caveat emptor: single nucleotide polymorphism reporting in pharmacogenomics. Pharmacology. 92: 319-23. PMID 24356117 DOI: 10.1159/000356324  1
2013 Vrana KE. "Making it real" time. Biotechniques. 54: 312-3. PMID 23905171 DOI: 10.2144/000114042  1
2013 Karpa KD, Vrana KE. Creating a virtual pharmacology curriculum in a problem-based learning environment: one medical school's experience. Academic Medicine : Journal of the Association of American Medical Colleges. 88: 198-205. PMID 23269297 DOI: 10.1097/ACM.0b013e31827c083d  1
2012 Dowhower Karpa K, Paul IM, Leckie JA, Shung S, Carkaci-Salli N, Vrana KE, Mauger D, Fausnight T, Poger J. A retrospective chart review to identify perinatal factors associated with food allergies. Nutrition Journal. 11: 87. PMID 23078601 DOI: 10.1186/1475-2891-11-87  1
2012 Torrente MP, Freeman WM, Vrana KE. Protein biomarkers of alcohol abuse. Expert Review of Proteomics. 9: 425-36. PMID 22967079 DOI: 10.1586/epr.12.38  1
2012 Huber-Keener KJ, Liu X, Wang Z, Wang Y, Freeman W, Wu S, Planas-Silva MD, Ren X, Cheng Y, Zhang Y, Vrana K, Liu CG, Yang JM, Wu R. Differential gene expression in tamoxifen-resistant breast cancer cells revealed by a new analytical model of RNA-Seq data. Plos One. 7: e41333. PMID 22844461 DOI: 10.1371/journal.pone.0041333  1
2012 Carkaci-Salli N, Battula S, Wang X, Connor JR, Vrana KE. Gender-specific regulation of tyrosine hydroxylase in thymocyte differentiation antigen-1 knockout mice. Journal of Neuroscience Research. 90: 1583-8. PMID 22430860 DOI: 10.1002/jnr.23046  1
2012 Torrente MP, Gelenberg AJ, Vrana KE. Boosting serotonin in the brain: is it time to revamp the treatment of depression? Journal of Psychopharmacology (Oxford, England). 26: 629-35. PMID 22158544 DOI: 10.1177/0269881111430744  1
2012 Helms CM, Messaoudi I, Jeng S, Freeman WM, Vrana KE, Grant KA. A longitudinal analysis of circulating stress-related proteins and chronic ethanol self-administration in cynomolgus macaques. Alcoholism, Clinical and Experimental Research. 36: 995-1003. PMID 22141444 DOI: 10.1111/j.1530-0277.2011.01685.x  1
2011 Freeman WM, Vanguilder HD, Guidone E, Krystal JH, Grant KA, Vrana KE. Plasma proteomic alterations in non-human primates and humans after chronic alcohol self-administration. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 14: 899-911. PMID 21303580 DOI: 10.1017/S1461145711000046  1
2011 Carkaci-Salli N, Salli U, Kuntz-Melcavage KL, Pennock MM, Ozgen H, Tekin I, Freeman WM, Vrana KE. TPH2 in the ventral tegmental area of the male rat brain. Brain Research Bulletin. 84: 376-80. PMID 21272616 DOI: 10.1016/j.brainresbull.2011.01.006  1
2011 Plazas-Mayorca MD, Vrana KE. Proteomic investigation of epigenetics in neuropsychiatric disorders: a missing link between genetics and behavior? Journal of Proteome Research. 10: 58-65. PMID 20735116 DOI: 10.1021/pr100463y  1
2010 Freeman WM, Vrana KE. Future prospects for biomarkers of alcohol consumption and alcohol-induced disorders. Alcoholism, Clinical and Experimental Research. 34: 946-54. PMID 20374220 DOI: 10.1111/j.1530-0277.2010.01169.x  1
2010 Mathew R, Jia W, Sharma A, Zhao Y, Clarke LE, Cheng X, Wang H, Salli U, Vrana KE, Robertson GP, Zhu J, Wang S. Robust activation of the human but not mouse telomerase gene during the induction of pluripotency. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 2702-15. PMID 20354136 DOI: 10.1096/fj.09-148973  1
2010 Umstead TM, Lu CJ, Freeman WM, Myers JL, Clark JB, Thomas NJ, Chinchilli VM, Vrana KE, Undar A, Phelps DS. Dual-platform proteomics study of plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass. Pediatric Research. 67: 641-9. PMID 20308938 DOI: 10.1203/PDR.0b013e3181dceef5  1
2010 Freeman WM, Salzberg AC, Gonzales SW, Grant KA, Vrana KE. Classification of alcohol abuse by plasma protein biomarkers. Biological Psychiatry. 68: 219-22. PMID 20299005 DOI: 10.1016/j.biopsych.2010.01.028  1
2010 Freeman WM, Lull ME, Patel KM, Brucklacher RM, Morgan D, Roberts DC, Vrana KE. Gene expression changes in the medial prefrontal cortex and nucleus accumbens following abstinence from cocaine self-administration. Bmc Neuroscience. 11: 29. PMID 20187946 DOI: 10.1186/1471-2202-11-29  1
2010 Desai D, Salli U, Vrana KE, Amin S. SelSA, selenium analogs of SAHA as potent histone deacetylase inhibitors. Bioorganic & Medicinal Chemistry Letters. 20: 2044-7. PMID 20167479 DOI: 10.1016/j.bmcl.2009.07.068  1
2010 Achur RN, Freeman WM, Vrana KE. Circulating cytokines as biomarkers of alcohol abuse and alcoholism. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 5: 83-91. PMID 20020329 DOI: 10.1007/s11481-009-9185-z  1
2010 Lull ME, Freeman WM, VanGuilder HD, Vrana KE. The use of neuroproteomics in drug abuse research. Drug and Alcohol Dependence. 107: 11-22. PMID 19926406 DOI: 10.1016/j.drugalcdep.2009.10.001  1
2009 Barthéléry M, Jaishankar A, Salli U, Freeman WM, Vrana KE. 2-D DIGE identification of differentially expressed heterogeneous nuclear ribonucleoproteins and transcription factors during neural differentiation of human embryonic stem cells. Proteomics. Clinical Applications. 3: 505-14. PMID 21136975 DOI: 10.1002/prca.200800109  1
2009 Lull ME, Erwin MS, Morgan D, Roberts DC, Vrana KE, Freeman WM. Persistent proteomic alterations in the medial prefrontal cortex with abstinence from cocaine self-administration. Proteomics. Clinical Applications. 3: 462-472. PMID 20161123 DOI: 10.1002/prca.200800055  1
2009 Undar A, Pauliks L, Clark JB, Zahn J, Rosenberg G, Kunselman AR, Sun Q, Pekkan K, Saliba K, Carney E, Thomas N, Freeman W, Vrana K, El-Banayosy A, Ural SH, et al. Penn State Hershey--center for pediatric cardiovascular research. Artificial Organs. 33: 883-7. PMID 20021467 DOI: 10.1111/j.1525-1594.2009.00889.x  1
2009 Lei F, Haque R, Weiler L, Vrana KE, Song J. T lineage differentiation from induced pluripotent stem cells. Cellular Immunology. 260: 1-5. PMID 19811778 DOI: 10.1016/j.cellimm.2009.09.005  1
2009 Kuntz-Melcavage KL, Brucklacher RM, Grigson PS, Freeman WM, Vrana KE. Gene expression changes following extinction testing in a heroin behavioral incubation model. Bmc Neuroscience. 10: 95. PMID 19664213 DOI: 10.1186/1471-2202-10-95  1
2009 Jaishankar A, Vrana KE. Emerging molecular approaches in stem cell biology Biotechniques. 46: 367-371. PMID 19480634 DOI: 10.2144/000113144  1
2009 Barthéléry M, Jaishankar A, Salli U, Vrana KE. Reptin52 expression during in vitro neural differentiation of human embryonic stem cells. Neuroscience Letters. 452: 47-51. PMID 19444951 DOI: 10.1016/j.neulet.2009.01.023  1
2009 Miller A, Lu CK, Wang S, Umstead TM, Freeman WM, Vrana K, Yang S, Myers JL, Phelps DS, Zahn JD, Undar A. Pediatric cardiopulmonary bypass circuits: a review of studies conducted at the Penn State Pediatric Cardiac Research Laboratories. The Journal of Extra-Corporeal Technology. 41: P50-8. PMID 19361042  1
2009 Jaishankar A, Barthelery M, Freeman WM, Salli U, Ritty TM, Vrana KE. Human embryonic and mesenchymal stem cells express different nuclear proteomes. Stem Cells and Development. 18: 793-802. PMID 18821827 DOI: 10.1089/scd.2008.0156  1
2009 Salli U, Fox TE, Carkaci-Salli N, Sharma A, Robertson GP, Kester M, Vrana KE. Propagation of undifferentiated human embryonic stem cells with nano-liposomal ceramide. Stem Cells and Development. 18: 55-65. PMID 18393629 DOI: 10.1089/scd.2007.0271  1
2008 Kuntz-Melcavage KL, Freeman WM, Vrana KE. CNS genes implicated in relapse. Substance Abuse : Research and Treatment. 2: 1-12. PMID 25922574  0.6
2008 Lull ME, Freeman WM, Vrana KE, Mash DC. Correlating human and animal studies of cocaine abuse and gene expression. Annals of the New York Academy of Sciences. 1141: 58-75. PMID 18991951 DOI: 10.1196/annals.1441.013  1
2008 VanGuilder HD, Vrana KE, Freeman WM. Twenty-five years of quantitative PCR for gene expression analysis. Biotechniques. 44: 619-26. PMID 18474036 DOI: 10.2144/000112776  1
2008 Kuntz KL, Twining RC, Baldwin AE, Vrana KE, Grigson PS. Heroin self-administration: I. Incubation of goal-directed behavior in rats. Pharmacology, Biochemistry, and Behavior. 90: 344-8. PMID 18471868 DOI: 10.1016/j.pbb.2008.03.018  1
2008 Kuntz KL, Patel KM, Grigson PS, Freeman WM, Vrana KE. Heroin self-administration: II. CNS gene expression following withdrawal and cue-induced drug-seeking behavior. Pharmacology, Biochemistry, and Behavior. 90: 349-56. PMID 18466961 DOI: 10.1016/j.pbb.2008.03.019  1
2008 Barthéléry M, Salli U, Vrana KE. Enhanced nuclear proteomics. Proteomics. 8: 1832-8. PMID 18384104 DOI: 10.1002/pmic.200700841  1
2008 Lull ME, Carkaci-Salli N, Freeman WM, Myers JL, Midgley FM, Thomas NJ, Kimatian SJ, Vrana KE, Undar A. Plasma biomarkers in pediatric patients undergoing cardiopulmonary bypass. Pediatric Research. 63: 638-44. PMID 18317239 DOI: 10.1203/PDR.0b013e31816e391f  1
2008 Freeman WM, Patel KM, Brucklacher RM, Lull ME, Erwin M, Morgan D, Roberts DC, Vrana KE. Persistent alterations in mesolimbic gene expression with abstinence from cocaine self-administration. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 33: 1807-17. PMID 17851536 DOI: 10.1038/sj.npp.1301577  1
2008 Jones JD, Carney ST, Vrana KE, Norford DC, Howlett AC. Cannabinoid receptor-mediated translocation of NO-sensitive guanylyl cyclase and production of cyclic GMP in neuronal cells. Neuropharmacology. 54: 23-30. PMID 17707868 DOI: 10.1016/j.neuropharm.2007.06.027  1
2007 Salli U, Long SW, Carlsen WS, Vrana KE. Stem cell biology should be taught in high schools. Cbe Life Sciences Education. 6: 283-4. PMID 18056298 DOI: 10.1187/cbe.07-06-0041  1
2007 Barthelery M, Salli U, Vrana KE. Nuclear proteomics and directed differentiation of embryonic stem cells. Stem Cells and Development. 16: 905-19. PMID 17999636 DOI: 10.1089/scd.2007.0071  1
2007 Ward GR, Franklin SO, Gerald TM, Dempsey KT, Clodfelter DE, Krissinger DJ, Patel KM, Vrana KE, Howlett AC. Glucocorticoids plus opioids up-regulate genes that influence neuronal function. Cellular and Molecular Neurobiology. 27: 651-60. PMID 17554624 DOI: 10.1007/s10571-007-9151-3  1
2007 Fitzpatrick LR, Hertzog KL, Quatse AL, Koltun WA, Small JS, Vrana K. Effects of the probiotic formulation VSL#3 on colitis in weanling rats Journal of Pediatric Gastroenterology and Nutrition. 44: 561-570. PMID 17460487 DOI: 10.1097/MPG.0b013e31803bda51  1
2007 Bowyer JF, Pogge AR, Delongchamp RR, O'Callaghan JP, Patel KM, Vrana KE, Freeman WM. A threshold neurotoxic amphetamine exposure inhibits parietal cortex expression of synaptic plasticity-related genes. Neuroscience. 144: 66-76. PMID 17049170 DOI: 10.1016/j.neuroscience.2006.08.076  1
2006 Cibelli JB, Cunniff K, Vrana KE. Embryonic stem cells from parthenotes. Methods in Enzymology. 418: 117-35. PMID 17141033 DOI: 10.1016/S0076-6879(06)18008-8  1
2006 Lull ME, Freeman WM, Myers JL, Midgley F, Kimatian SJ, Undar A, Vrana KE. Plasma proteomics: a noninvasive window on pathology and pediatric cardiac surgery. Asaio Journal (American Society For Artificial Internal Organs : 1992). 52: 562-6. PMID 16966860 DOI: 10.1097/01.mat.0000237694.53808.78  1
2006 Carkaci-Salli N, Flanagan JM, Martz MK, Salli U, Walther DJ, Bader M, Vrana KE. Functional domains of human tryptophan hydroxylase 2 (hTPH2). The Journal of Biological Chemistry. 281: 28105-12. PMID 16864580 DOI: 10.1074/jbc.M602817200  1
2006 Freeman WM, Lull ME, Guilford MT, Vrana KE. Depletion of abundant proteins from non-human primate serum for biomarker studies. Proteomics. 6: 3109-13. PMID 16619306 DOI: 10.1002/pmic.200500717  1
2006 Freeman WM, Gooch RS, Lull ME, Worst TJ, Walker SJ, Xu AS, Green H, Pierre PJ, Grant KA, Vrana KE. Apo-AII is an elevated biomarker of chronic non-human primate ethanol self-administration. Alcohol and Alcoholism (Oxford, Oxfordshire). 41: 300-5. PMID 16581821 DOI: 10.1093/alcalc/agl021  1
2005 McCracken CB, Hamby SM, Patel KM, Morgan D, Vrana KE, Roberts DC. Extended cocaine self-administration and deprivation produces region-specific and time-dependent changes in connexin36 expression in rat brain. Synapse (New York, N.Y.). 58: 141-50. PMID 16138316 DOI: 10.1002/syn.20194  1
2005 Worst TJ, Tan JC, Robertson DJ, Freeman WM, Hyytia P, Kiianmaa K, Vrana KE. Transcriptome analysis of frontal cortex in alcohol-preferring and nonpreferring rats. Journal of Neuroscience Research. 80: 529-38. PMID 15846778 DOI: 10.1002/jnr.20496  1
2005 McCracken CB, Patel KM, Vrana KE, Paul DL, Roberts DC. Amphetamine withdrawal produces region-specific and time-dependent changes in connexin36 expression in rat brain. Synapse (New York, N.Y.). 56: 39-44. PMID 15700285 DOI: 10.1002/syn.20127  1
2005 Worst TJ, Vrana KE. Alcohol and gene expression in the central nervous system. Alcohol and Alcoholism (Oxford, Oxfordshire). 40: 63-75. PMID 15569717 DOI: 10.1093/alcalc/agh119  1
2004 Stredrick DL, Stokes AH, Worst TJ, Freeman WM, Johnson EA, Lash LH, Aschner M, Vrana KE. Manganese-induced cytotoxicity in dopamine-producing cells. Neurotoxicology. 25: 543-53. PMID 15183009 DOI: 10.1016/j.neuro.2003.08.006  1
2004 Walker SJ, Worst TJ, Freeman WM, Vrana KE. Functional genomic analysis in pain research using hybridization arrays. Methods in Molecular Medicine. 99: 239-53. PMID 15131342 DOI: 10.1385/1-59259-770-X:239  1
2004 Kasinathan C, Vrana K, Beretta L, Thomas P, Gooch R, Worst T, Walker S, Xu A, Pierre P, Green H, Grant K, Manowitz P. The Future of Proteomics in the Study of Alcoholism Alcoholism: Clinical and Experimental Research. 28: 228-232. PMID 15112930 DOI: 10.1097/01.ALC.0000113779.35260.A8  1
2004 Gooch RS, Worst TJ, Freeman WM, Vrana KE. cDNA Arrays in Alcohol-Related Pathology: Methods and Approaches Comprehensive Handbook of Alcohol Related Pathology. 3: 1597-1610. DOI: 10.1016/B978-012564370-2/50120-3  1
2003 Yohrling GJ, Jiang GC, DeJohn MM, Miller DW, Young AB, Vrana KE, Cha JH. Analysis of cellular, transgenic and human models of Huntington's disease reveals tyrosine hydroxylase alterations and substantia nigra neuropathology. Brain Research. Molecular Brain Research. 119: 28-36. PMID 14597227 DOI: 10.1016/j.molbrainres.2003.08.009  1
2003 Vrana KE, Hipp JD, Goss AM, McCool BA, Riddle DR, Walker SJ, Wettstein PJ, Studer LP, Tabar V, Cunniff K, Chapman K, Vilner L, West MD, Grant KA, Cibelli JB. Nonhuman primate parthenogenetic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 100: 11911-6. PMID 14504386 DOI: 10.1073/pnas.2034195100  1
2003 Vrana KE, Freeman WM, Aschner M. Use of microarray technologies in toxicology research. Neurotoxicology. 24: 321-32. PMID 12782098 DOI: 10.1016/S0161-813X(02)00193-6  1
2003 Patel VB, Chaurand P, Caprioli RM, Austen BM, Frears ER, Manca F, Davies H, Vrana KE, Wheeler M, Preedy VR. Emerging techniques in biomedical research and their application to alcohol toxicity. Alcoholism, Clinical and Experimental Research. 27: 348-53. PMID 12605084 DOI: 10.1097/01.ALC.0000052580.14492.21  1
2003 Worst TJ, Freeman WM, Walker SJ, Vrana KE. Systematic screening of gene expression using a cDNA macroarray. Methods in Molecular Medicine. 79: 243-59. PMID 12506701  1
2003 Walker SJ, Worst TJ, Vrana KE. Semiquantitative real-time PCR for analysis of mRNA levels. Methods in Molecular Medicine. 79: 211-27. PMID 12506699  1
2002 Freeman WM, Dougherty KE, Vacca SE, Vrana KE. An interactive database of cocaine-responsive gene expression. Thescientificworldjournal. 2: 701-6. PMID 12805995 DOI: 10.1100/tsw.2002.145  1
2002 Stokes AH, Freeman WM, Mitchell SG, Burnette TA, Hellmann GM, Vrana KE. Induction of GADD45 and GADD153 in neuroblastoma cells by dopamine-induced toxicity. Neurotoxicology. 23: 675-84. PMID 12520757 DOI: 10.1016/S0161-813X(02)00093-1  1
2002 Freeman WM, Brebner K, Patel KM, Lynch WJ, Roberts DC, Vrana KE. Repeated cocaine self-administration causes multiple changes in rat frontal cortex gene expression. Neurochemical Research. 27: 1181-92. PMID 12462416 DOI: 10.1023/A:1020929526688  1
2002 Yohrling IV GJ, Jiang GC, DeJohn MM, Robertson DJ, Vrana KE, Cha JH. Inhibition of tryptophan hydroxylase activity and decreased 5-HT1A receptor binding in a mouse model of Huntington's disease. Journal of Neurochemistry. 82: 1416-23. PMID 12354289 DOI: 10.1046/j.1471-4159.2002.01084.x  1
2002 Weber S, Dorman DC, Lash LH, Erikson K, Vrana KE, Aschner M. Effects of manganese (Mn) on the developing rat brain: oxidative-stress related endpoints. Neurotoxicology. 23: 169-75. PMID 12224758 DOI: 10.1016/S0161-813X(02)00014-1  1
2002 Freeman WM, Brebner K, Lynch WJ, Patel KM, Robertson DJ, Roberts DC, Vrana KE. Changes in rat frontal cortex gene expression following chronic cocaine. Brain Research. Molecular Brain Research. 104: 11-20. PMID 12117546 DOI: 10.1016/S0169-328X(02)00197-3  1
2002 Haycock JW, Kumer SC, Lewis DA, Vrana KE, Stockmeier CA. A monoclonal antibody to tryptophan hydroxylase: applications and identification of the epitope. Journal of Neuroscience Methods. 114: 205-12. PMID 11856572 DOI: 10.1016/S0165-0270(01)00530-1  1
2002 Cibelli JB, Grant KA, Chapman KB, Cunniff K, Worst T, Green HL, Walker SJ, Gutin PH, Vilner L, Tabar V, Dominko T, Kane J, Wettstein PJ, Lanza RP, Studer L, ... Vrana KE, et al. Parthenogenetic stem cells in nonhuman primates. Science (New York, N.Y.). 295: 819. PMID 11823632 DOI: 10.1126/science.1065637  1
2001 Freeman WM, Brebner K, Lynch WJ, Robertson DJ, Roberts DC, Vrana KE. Cocaine-responsive gene expression changes in rat hippocampus. Neuroscience. 108: 371-80. PMID 11738252 DOI: 10.1016/S0306-4522(01)00432-8  1
2001 Blanchard-Fillion B, Souza JM, Friel T, Jiang GC, Vrana K, Sharov V, Barrón L, Schöneich C, Quijano C, Alvarez B, Radi R, Przedborski S, Fernando GS, Horwitz J, Ischiropoulos H. Nitration and inactivation of tyrosine hydroxylase by peroxynitrite. The Journal of Biological Chemistry. 276: 46017-23. PMID 11590168 DOI: 10.1074/jbc.M105564200  1
2001 Walker SJ, Grant KA, Vrana KE. Examination of a CYP2E1 repeat polymorphism in a monkey model of alcohol abuse. Alcoholism, Clinical and Experimental Research. 25: 1114-8. PMID 11505041  1
2001 Freeman WM, Nader MA, Nader SH, Robertson DJ, Gioia L, Mitchell SM, Daunais JB, Porrino LJ, Friedman DP, Vrana KE. Chronic cocaine-mediated changes in non-human primate nucleus accumbens gene expression. Journal of Neurochemistry. 77: 542-9. PMID 11299316 DOI: 10.1046/j.1471-4159.2001.00382.x  1
2000 Freeman WM, Robertson DJ, Vrana KE. Fundamentals of DNA hybridization arrays for gene expression analysis. Biotechniques. 29: 1042-6, 1048-55. PMID 11084867  1
2000 Freeman WM, Yohrling GJ, Daunais JB, Gioia L, Hart SL, Porrino LJ, Davies HM, Vrana KE. A cocaine analog, 2beta-propanoyl-3beta-(4-tolyl)-tropane (PTT), reduces tyrosine hydroxylase in the mesolimbic dopamine pathway. Drug and Alcohol Dependence. 61: 15-21. PMID 11064180 DOI: 10.1016/S0376-8716(00)00119-8  1
2000 Jiang GC, Yohrling GJ, Schmitt JD, Vrana KE, Yohrling GJ, Schmitt IV. Identification of substrate orienting and phosphorylation sites within tryptophan hydroxylase using homology-based molecular modeling. Journal of Molecular Biology. 302: 1005-17. PMID 10993738 DOI: 10.1006/jmbi.2000.4097  1
2000 Yohrling GJ, Jiang GC, Mockus SM, Vrana KE. Intersubunit binding domains within tyrosine hydroxylase and tryptophan hydroxylase. Journal of Neuroscience Research. 61: 313-20. PMID 10900078 DOI: 10.1002/1097-4547(20000801)61:3<313::AID-JNR9>3.0.CO;2-9  1
2000 Stokes AH, Xu Y, Daunais JA, Tamir H, Gershon MD, Butkerait P, Kayser B, Altman J, Beck W, Vrana KE. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. Journal of Neurochemistry. 74: 2067-73. PMID 10800950 DOI: 10.1046/j.1471-4159.2000.0742067.x  1
2000 Stokes AH, Lewis DY, Lash LH, Jerome WG, Grant KW, Aschner M, Vrana KE. Dopamine toxicity in neuroblastoma cells: role of glutathione depletion by L-BSO and apoptosis. Brain Research. 858: 1-8. PMID 10700589 DOI: 10.1016/S0006-8993(99)02329-X  1
1999 Yohrling GJ, Mockus SM, Vrana KE. Identification of amino-terminal sequences contributing to tryptophan hydroxylase tetramer formation. Journal of Molecular Neuroscience : Mn. 12: 23-34. PMID 10636468 DOI: 10.1385/JMN:12:1:23  1
1999 Letchworth SR, Sexton T, Childers SR, Vrana KE, Vaughan RA, Davies HM, Porrino LJ. Regulation of rat dopamine transporter mRNA and protein by chronic cocaine administration. Journal of Neurochemistry. 73: 1982-9. PMID 10537056  1
1999 Aschner M, Vrana KE, Zheng W. Manganese uptake and distribution in the central nervous system (CNS). Neurotoxicology. 20: 173-80. PMID 10385881  1
1999 Vrana KE. How the regulatory and catalytic domains get together. Nature Structural Biology. 6: 401-2. PMID 10331859 DOI: 10.1038/8192  1
1999 Stokes AH, Hastings TG, Vrana KE. Cytotoxic and genotoxic potential of dopamine. Journal of Neuroscience Research. 55: 659-65. PMID 10220107 DOI: 10.1002/(SICI)1097-4547(19990315)55:6<659::AID-JNR1>3.0.CO;2-C  1
1999 Freeman WM, Walker SJ, Vrana KE. Quantitative RT-PCR: pitfalls and potential. Biotechniques. 26: 112-22, 124-5. PMID 9894600  1
1998 Xu Y, Stokes AH, Roskoski R, Vrana KE. Dopamine, in the presence of tyrosinase, covalently modifies and inactivates tyrosine hydroxylase. Journal of Neuroscience Research. 54: 691-7. PMID 9843160 DOI: 10.1002/(SICI)1097-4547(19981201)54:5<691::AID-JNR14>3.0.CO;2-F  1
1998 Mockus SM, Vrana KE. Advances in the molecular characterization of tryptophan hydroxylase. Journal of Molecular Neuroscience : Mn. 10: 163-79. PMID 9770640 DOI: 10.1007/BF02761772  1
1998 Vogt BA, Vogt LJ, Vrana KE, Gioia L, Meadows RS, Challa VR, Hof PR, Van Hoesen GW. Multivariate analysis of laminar patterns of neurodegeneration in posterior cingulate cortex in Alzheimer's disease. Experimental Neurology. 153: 8-22. PMID 9743563 DOI: 10.1006/exnr.1998.6852  1
1998 Gioia L, Vogt LJ, Freeman WM, Flood A, Vogt BA, Vrana KE. PCR-based apolipoprotein E genotype analysis from archival fixed brain. Journal of Neuroscience Methods. 80: 209-14. PMID 9667394 DOI: 10.1016/S0165-0270(98)00002-8  1
1998 Mockus SM, Yohrling GJ, Vrana KE. Tyrosine hydroxylase and tryptophan hydroxylase do not form heterotetramers. Journal of Molecular Neuroscience : Mn. 10: 45-51. PMID 9589369 DOI: 10.1007/BF02737084  1
1998 Aschner M, Stark S, Vrana KE, Conklin DR. Acidosis-induced metallothionein (MT) mRNA expression in neonatal rat primary astrocyte cultures. Neurotoxicology. 19: 227-36. PMID 9553959  1
1997 Mockus SM, Kumer SC, Vrana KE. Carboxyl terminal deletion analysis of tryptophan hydroxylase. Biochimica Et Biophysica Acta. 1342: 132-40. PMID 9392522 DOI: 10.1016/S0167-4838(97)00069-1  1
1997 Mockus SM, Kumer SC, Vrana KE. A chimeric tyrosine/tryptophan hydroxylase. The tyrosine hydroxylase regulatory domain serves to stabilize enzyme activity. Journal of Molecular Neuroscience : Mn. 9: 35-48. PMID 9356925 DOI: 10.1007/BF02789393  1
1997 Kumer SC, Mockus SM, Rucker PJ, Vrana KE. Amino-terminal analysis of tryptophan hydroxylase: protein kinase phosphorylation occurs at serine-58. Journal of Neurochemistry. 69: 1738-45. PMID 9326303  1
1997 van de Pavert SA, Clarke IJ, Rao A, Vrana KE, Schwartz J. Effects of vasopressin and elimination of corticotropin-releasing hormone-target cells on pro-opiomelanocortin mRNA levels and adrenocorticotropin secretion in ovine anterior pituitary cells. The Journal of Endocrinology. 154: 139-47. PMID 9246948 DOI: 10.1677/joe.0.1540139  1
1997 Xu Y, Stokes AH, Freeman WM, Kumer SC, Vogt BA, Vrana KE. Tyrosinase mRNA is expressed in human substantia nigra. Brain Research. Molecular Brain Research. 45: 159-62. PMID 9105685 DOI: 10.1016/S0169-328X(96)00308-7  1
1996 Vrana KE. Advancing technologies in gene amplification. Trends in Biotechnology. 14: 413-5. PMID 8940771 DOI: 10.1016/0167-7799(96)30022-X  1
1996 Stokes AH, Brown BG, Lee CK, Doolittle DJ, Vrana KE. Tyrosinase enhances the covalent modification of DNA by dopamine. Brain Research. Molecular Brain Research. 42: 167-70. PMID 8915597 DOI: 10.1016/S0169-328X(96)00164-7  1
1996 Kumer SC, Vrana KE. Intricate regulation of tyrosine hydroxylase activity and gene expression. Journal of Neurochemistry. 67: 443-62. PMID 8764568  1
1996 Freeman WM, Vrana SL, Vrana KE. Use of elevated reverse transcription reaction temperatures in RT-PCR. Biotechniques. 20: 782-3. PMID 8723916  1
1995 Vrana SL, Kluttz BW, Vrana KE. Application of quantitative RT-PCR to the analysis of dopamine receptor mRNA levels in rat striatum. Brain Research. Molecular Brain Research. 34: 127-34. PMID 8750868 DOI: 10.1016/0169-328X(95)00152-I  1
1995 Dopke KL, Vrana KE, Vogt LJ, Vogt BA. AF-DX 384 binding in rabbit cingulate cortex: two site kinetics and section autoradiography. The Journal of Pharmacology and Experimental Therapeutics. 274: 562-9. PMID 7616446  1
1995 Kluttz BW, Vrana KE, Dworkin SI, Childers SR. Effects of morphine on forskolin-stimulated pro-enkephalin mRNA levels in rat striatum: a model for acute and chronic opioid actions in brain. Brain Research. Molecular Brain Research. 32: 313-20. PMID 7500843 DOI: 10.1016/0169-328X(95)00100-7  1
1994 Vrana KE, Rucker PJ, Kumer SC. Recombinant rabbit tryptophan hydroxylase is a substrate for cAMP-dependent protein kinase. Life Sciences. 55: 1045-52. PMID 8084209 DOI: 10.1016/0024-3205(94)00639-3  1
1994 Vrana KE, Walker SJ, Rucker P, Liu X. A carboxyl terminal leucine zipper is required for tyrosine hydroxylase tetramer formation. Journal of Neurochemistry. 63: 2014-20. PMID 7964718  1
1994 Walker SJ, Liu X, Roskoski R, Vrana KE. Catalytic core of rat tyrosine hydroxylase: terminal deletion analysis of bacterially expressed enzyme. Biochimica Et Biophysica Acta. 1206: 113-9. PMID 7910484 DOI: 10.1016/0167-4838(94)90079-5  1
1993 Vrana SL, Dworkin SI, Vrana KE. Radioenzymatic assay for tryptophan hydroxylase: [3H]H2O release assessed by charcoal adsorption. Journal of Neuroscience Methods. 48: 123-9. PMID 8377514 DOI: 10.1016/S0165-0270(05)80014-7  1
1993 Walker SJ, Vrana KE. Pituitary corticotroph function during the stress hyporesponsive period in neonatal rats. Neuroendocrinology. 57: 1003-10. PMID 8232758 DOI: 10.1159/000126464  1
1993 Vrana SL, Vrana KE, Koves TR, Smith JE, Dworkin SI. Chronic cocaine administration increases CNS tyrosine hydroxylase enzyme activity and mRNA levels and tryptophan hydroxylase enzyme activity levels. Journal of Neurochemistry. 61: 2262-8. PMID 7902421 DOI: 10.1111/j.1471-4159.1993.tb07468.x  1
1992 Huffman L, Michalkiewicz M, Vrana KE, Hedge GA. Expression of preproNPY and precursor VIP mRNAs in rats under hypo- or hyperthyroid conditions. Molecular and Cellular Neurosciences. 3: 418-24. PMID 19912885 DOI: 10.1016/1044-7431(92)90053-5  1
1992 Vrana SL, Azzaro AJ, Vrana KE. Chronic selegiline administration transiently decreases tyrosine hydroxylase activity and mRNA in the rat nigrostriatal pathway. Molecular Pharmacology. 41: 839-44. PMID 1350320  1
1991 Liu X, Vrana KE. Leucine zippers and coiled-coils in the aromatic amino acid hydroxylases. Neurochemistry International. 18: 27-31. PMID 20504671 DOI: 10.1016/0197-0186(91)90031-8  1
1991 Lamport-Vrana SJ, Vrana KE, Fedan JS. Involvement of ecto-phosphoryl transfer in contractions of the smooth muscle of the guinea pig vas deferens to adenosine 5'-triphosphate. The Journal of Pharmacology and Experimental Therapeutics. 258: 339-48. PMID 2072306  1
1990 Liu X, Giza CC, Vrana KE. High efficiency transient expression of eukaryotic genes: use of an HSV-1 immediate early promoter (ICP4). Biotechniques. 9: 168-73. PMID 2169263  1
1990 Roskoski R, Wilgus H, Vrana KE. Inactivation of tyrosine hydroxylase by pterin substrates following phosphorylation by cyclic AMP-dependent protein kinase. Molecular Pharmacology. 38: 541-6. PMID 1978241  1
1989 Ardekani AM, Walker SJ, Donohue SJ, Stitzel RE, Connors JM, Vrana KE. Adrenocorticotropin and corticosterone levels in pre-weanling spontaneously hypertensive rats. Life Sciences. 44: 919-25. PMID 2538695 DOI: 10.1016/0024-3205(89)90490-6  1
1988 Vrana KE, Churchill ME, Tullius TD, Brown DD. Mapping functional regions of transcription factor TFIIIA. Molecular and Cellular Biology. 8: 1684-96. PMID 2837652  1
1987 Kubinec J, Vrana KE, Roskoski R. Paraoxon-induced decrease in the muscarinic acetylcholine receptor content in rat heart. European Journal of Pharmacology. 136: 295-301. PMID 3609123 DOI: 10.1016/0014-2999(87)90301-3  1
1985 Wilgus H, Vrana KE, Roskoski R. Inactivation of tyrosine hydroxylase (TH) by reduced pterins, reducing agents, thiol reagents, and iron chelators under non-phosphorylating (-P) and cyclic AMP-dependent phosphorylating (+P) conditions Federation Proceedings. 44: 3844.  1
1985 Kubinec J, Vrana KE, Younathan C, Roskoski R. Paraoxon-induced decrease in the cholinergic muscarinic receptor content of rat heart Federation Proceedings. 44: No. 8285.  1
1983 Vrana KE, Roskoski R. Tyrosine hydroxylase inactivation following cAMP-dependent phosphorylation activation. Journal of Neurochemistry. 40: 1692-700. PMID 6133915  1
1982 Cook PF, Neville ME, Vrana KE, Hartl FT, Roskoski R. Adenosine cyclic 3',5'-monophosphate dependent protein kinase: kinetic mechanism for the bovine skeletal muscle catalytic subunit. Biochemistry. 21: 5794-9. PMID 6295440 DOI: 10.1021/BI00266A011  1
1981 Vrana KE, Allhiser CL, Roskoski R. Tyrosine hydroxylase activation and inactivation by protein phosphorylation conditions. Journal of Neurochemistry. 36: 92-100. PMID 6109760  1
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