Allyn C. Howlett - Publications

Saint Louis University, St. Louis, MO, United States 
Pharmacology, Neuroscience Biology

142 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Howlett AC, Thomas BF, Huffman JW. The Spicy Story of Cannabimimetic Indoles. Molecules (Basel, Switzerland). 26. PMID 34684770 DOI: 10.3390/molecules26206190  0.36
2020 Oliver EE, Hughes EK, Puckett MK, Chen R, Lowther WT, Howlett AC. Cannabinoid Receptor Interacting Protein 1a (CRIP1a) in Health and Disease. Biomolecules. 10. PMID 33261012 DOI: 10.3390/biom10121609  0.361
2020 Lyons EL, Leone-Kabler S, Kovach AL, Thomas BF, Howlett AC. Cannabinoid receptor subtype influence on neuritogenesis in human SH-SY5Y cells. Molecular and Cellular Neurosciences. 103566. PMID 33049367 DOI: 10.1016/j.mcn.2020.103566  0.371
2020 Dalton GD, Carney ST, Marshburn JD, Norford DC, Howlett AC. CB Cannabinoid Receptors Stimulate Gβγ-GRK2-Mediated FAK Phosphorylation at Tyrosine 925 to Regulate ERK Activation Involving Neuronal Focal Adhesions. Frontiers in Cellular Neuroscience. 14: 176. PMID 32655375 DOI: 10.3389/Fncel.2020.00176  0.379
2020 Schurman LD, Lu D, Kendall DA, Howlett AC, Lichtman AH. Molecular Mechanism and Cannabinoid Pharmacology. Handbook of Experimental Pharmacology. PMID 32236882 DOI: 10.1007/164_2019_298  0.491
2020 Eldeeb K, Wittmann TG, Leone-Kabler S, Howlett AC. The CB1 cannabinoid receptor‐mediated inhibition of cAMP accumulation in neuroblastoma cells: role of different Gi/o protein subtypes The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04298  0.32
2020 Kozakiewicz ML, Zhang J, Leone-Kabler S, Yamaleyeva LM, Brost BC, Howlett AC. 902: CB1 cannabinoid receptor and cannabinoid receptor interacting protein in human myometrium and placenta during labor American Journal of Obstetrics and Gynecology. 222: S560-S561. DOI: 10.1016/J.Ajog.2019.11.913  0.507
2019 Eldeeb K, Ganjiwale AD, Chandrashekaran IR, Padgett LW, Burgess J, Howlett AC, Cowsik SM. CB1 cannabinoid receptor-phosphorylated fourth intracellular loop structure-function relationships. Peptide Science (Hoboken, N.J.). 111. PMID 32411924 DOI: 10.1002/Pep2.24104  0.345
2019 Singh P, Ganjiwale AD, Howlett AC, Cowsik SM. Molecular interaction between distal C-terminal domain of the CB1 cannabinoid receptor and Cannabinoid Receptor Interacting Proteins (CRIP1a/CRIP1b). Journal of Chemical Information and Modeling. PMID 31769975 DOI: 10.1021/Acs.Jcim.9B00948  0.318
2019 Booth WT, Walker NB, Lowther WT, Howlett AC. Cannabinoid Receptor Interacting Protein 1a (CRIP1a): Function and Structure. Molecules (Basel, Switzerland). 24. PMID 31614728 DOI: 10.3390/Molecules24203672  0.518
2019 Abood M, Alexander SP, Barth F, Bonner TI, Bradshaw H, Cabral G, Casellas P, Cravatt BF, Devane WA, Di Marzo V, Elphick MR, Felder CC, Greasley P, Herkenham M, Howlett AC, et al. Cannabinoid receptors (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database Iuphar/Bps Guide to Pharmacology Cite. 2019. DOI: 10.2218/gtopdb/f13/2019.4  0.42
2018 Ilyasov AA, Milligan CE, Pharr EP, Howlett AC. The Endocannabinoid System and Oligodendrocytes in Health and Disease. Frontiers in Neuroscience. 12: 733. PMID 30416422 DOI: 10.3389/Fnins.2018.00733  0.388
2017 Singh P, Ganjiwale A, Howlett AC, Cowsik SM. In silico interaction analysis of cannabinoid receptor interacting protein 1b (CRIP1b) - CB1 cannabinoid receptor. Journal of Molecular Graphics & Modelling. 77: 311-321. PMID 28918320 DOI: 10.1016/J.Jmgm.2017.09.006  0.485
2017 Howlett AC, Abood ME. CB1 and CB2 Receptor Pharmacology. Advances in Pharmacology (San Diego, Calif.). 80: 169-206. PMID 28826534 DOI: 10.1016/Bs.Apha.2017.03.007  0.545
2017 Eldeeb K, Leone-Kabler S, Howlett AC. Mouse Neuroblastoma CB1 Cannabinoid Receptor-Stimulated [(35)S]GTPɣS Binding: Total and Antibody-Targeted Gα Protein-Specific Scintillation Proximity Assays. Methods in Enzymology. 593: 1-21. PMID 28750799 DOI: 10.1016/Bs.Mie.2017.06.028  0.45
2017 Singh P, Ganjiwale A, Howlett AC, Cowsik SM. Molecular Interactions of Cannabinoid Receptor Interacting Protein 1 A and B with Cannabinoid Receptor 1 Biophysical Journal. 112: 54a. DOI: 10.1016/J.Bpj.2016.11.331  0.37
2016 Budygin EA, Oleson EB, Lee YB, Blume LC, Bruno MJ, Howlett AC, Thompson AC, Bass CE. Acute Depletion of D2 Receptors from the Rat Substantia Nigra Alters Dopamine Kinetics in the Dorsal Striatum and Drug Responsivity. Frontiers in Behavioral Neuroscience. 10: 248. PMID 28154530 DOI: 10.3389/Fnbeh.2016.00248  0.704
2016 Blume LC, Patten T, Eldeeb K, Leone-Kabler S, Ilyasov AA, Keegan BM, O'Neal JE, Bass CE, Hantgan RR, Lowther WT, Selley DE, Howlett AC. Cannabinoid Receptor Interacting Protein (CRIP) 1a competition with β-arrestin for CB1 receptor binding sites. Molecular Pharmacology. PMID 27895162 DOI: 10.1124/Mol.116.104638  0.63
2016 Luessen DJ, Hinshaw TP, Sun H, Howlett AC, Marrs G, McCool BA, Chen R. RGS2 modulates the activity and internalization of dopamine D2 receptors in neuroblastoma N2A cells. Neuropharmacology. PMID 27528587 DOI: 10.1016/J.Neuropharm.2016.08.009  0.431
2016 Blume LC, Leone-Kabler S, Luessen DJ, Marrs GS, Lyons E, Bass CE, Chen R, Selley DE, Howlett AC. Cannabinoid Receptor Interacting Protein (CRIP1a) suppresses agonist-driven CB1 receptor internalization, and regulates receptor replenishment in an agonist-biased manner. Journal of Neurochemistry. PMID 27513693 DOI: 10.1111/Jnc.13767  0.716
2016 Eldeeb K, Leone-Kabler S, Howlett AC. CB1 cannabinoid receptor-mediated increases in cyclic AMP accumulation are correlated with reduced Gi/o function. Journal of Basic and Clinical Physiology and Pharmacology. 27: 311-22. PMID 27089415 DOI: 10.1515/Jbcpp-2015-0096  0.471
2016 Ganjiwale A, Eldeeb K, Chandrashekar I, Cowsik S, Howlett A. Phosphorylation of CB1Cannabinoid Receptor Fourth Intracellular Loop Peptides: Effects on Structure and Function Journal of Back and Musculoskeletal Rehabilitation. DOI: 10.2210/Pdb2Mz2/Pdb  0.382
2015 Keegan BM, Beveridge TJ, Pezor JJ, Xiao R, Sexton T, Childers SR, Howlett AC. Chronic baclofen desensitizes GABAB-mediated G-protein activation and stimulates phosphorylation of kinases in mesocorticolimbic rat brain. Neuropharmacology. 95: 492-502. PMID 25724082 DOI: 10.1016/J.Neuropharm.2015.02.021  0.417
2015 Smith TH, Blume LC, Straiker A, Cox JO, David BG, McVoy JR, Sayers KW, Poklis JL, Abdullah RA, Egertová M, Chen CK, Mackie K, Elphick MR, Howlett AC, Selley DE. Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation. Molecular Pharmacology. 87: 747-65. PMID 25657338 DOI: 10.1124/Mol.114.096495  0.523
2015 Schaich CL, Shaltout HA, Grabenauer M, Thomas BF, Gallagher PE, Howlett AC, Diz DI. Alterations in the Medullary Endocannabinoid System Contribute to Age-related Impairment of Baroreflex Sensitivity. Journal of Cardiovascular Pharmacology. 65: 473-9. PMID 25636077 DOI: 10.1097/Fjc.0000000000000216  0.36
2015 Blume LC, Eldeeb K, Bass CE, Selley DE, Howlett AC. Cannabinoid receptor interacting protein (CRIP1a) attenuates CB1R signaling in neuronal cells. Cellular Signalling. 27: 716-26. PMID 25446256 DOI: 10.1016/J.Cellsig.2014.11.006  0.711
2014 Mechoulam R, Hanuš LO, Pertwee R, Howlett AC. Early phytocannabinoid chemistry to endocannabinoids and beyond Nature Reviews Neuroscience. 15: 757-764. PMID 25315390 DOI: 10.1038/Nrn3811  0.334
2014 Schaich CL, Shaltout HA, Brosnihan KB, Howlett AC, Diz DI. Acute and chronic systemic CB1 cannabinoid receptor blockade improves blood pressure regulation and metabolic profile in hypertensive (mRen2)27 rats. Physiological Reports. 2. PMID 25168868 DOI: 10.14814/Phy2.12108  0.391
2014 Pulgar VM, Yamaleyeva LM, Varagic J, McGee CM, Bader M, Dechend R, Howlett AC, Brosnihan KB. Increased angiotensin II contraction of the uterine artery at early gestation in a transgenic model of hypertensive pregnancy is reduced by inhibition of endocannabinoid hydrolysis. Hypertension. 64: 619-25. PMID 24935942 DOI: 10.1161/Hypertensionaha.114.03633  0.313
2014 Calipari ES, Sun H, Eldeeb K, Luessen DJ, Feng X, Howlett AC, Jones SR, Chen R. Amphetamine self-administration attenuates dopamine D2 autoreceptor function. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 1833-42. PMID 24513972 DOI: 10.1038/Npp.2014.30  0.478
2014 Campeau L, Füllhase C, Sawada N, Gratzke C, Hedlund P, Howlett AC, Andersson KE. Characterization of bladder function in a cannabinoid receptor type 2 knockout mouse in vivo and in vitro. Neurourology and Urodynamics. 33: 566-70. PMID 23908133 DOI: 10.1002/Nau.22454  0.372
2014 Rai P, Howlett A, Cowsik SM. Structural Analysis of CRIP1a by in Silico Approaches Biophysical Journal. 106: 208a. DOI: 10.1016/J.Bpj.2013.11.1219  0.386
2014 Blume LC, Eldeeb KM, Howlett AC. Cannabinoid receptor intracellular signalling: The long journey from binding sites to biological effects Cannabinoids. 17-52. DOI: 10.1002/9781118451281.ch2  0.39
2013 Dalton GD, Peterson LJ, Howlett AC. CB₁ cannabinoid receptors promote maximal FAK catalytic activity by stimulating cooperative signaling between receptor tyrosine kinases and integrins in neuronal cells. Cellular Signalling. 25: 1665-77. PMID 23571270 DOI: 10.1016/J.Cellsig.2013.03.020  0.41
2013 Blume LC, Bass CE, Childers SR, Dalton GD, Roberts DC, Richardson JM, Xiao R, Selley DE, Howlett AC. Striatal CB1 and D2 receptors regulate expression of each other, CRIP1A and δ opioid systems. Journal of Neurochemistry. 124: 808-20. PMID 23286559 DOI: 10.1111/Jnc.12139  0.714
2013 Campeau L, Füllhase C, Hedlund P, Howlett A, Andersson K. 544 ROLE OF CANNABINOID AND TRPV1 RECEPTORS IN THE SPINAL MECHANISMS OF MICTURITION IN THE NORMAL RAT Journal of Urology. 189. DOI: 10.1016/J.Juro.2013.02.1939  0.393
2013 Campeau L, Füllhase C, Sawada N, Gratzke C, Hedlund P, Howlett A, Andersson K. 288 INVOLVEMENT OF CANNABINOID RECEPTOR TYPE 2 IN MICTURITION IN MICE Journal of Urology. 189. DOI: 10.1016/J.Juro.2013.02.1672  0.405
2012 Oddi S, Dainese E, Sandiford S, Fezza F, Lanuti M, Chiurchiù V, Totaro A, Catanzaro G, Barcaroli D, De Laurenzi V, Centonze D, Mukhopadhyay S, Selent J, Howlett AC, Maccarrone M. Effects of palmitoylation of Cys(415) in helix 8 of the CB(1) cannabinoid receptor on membrane localization and signalling. British Journal of Pharmacology. 165: 2635-51. PMID 21895628 DOI: 10.1111/J.1476-5381.2011.01658.X  0.502
2012 Dalton GD, Howlett AC. Cannabinoid CB1 receptors transactivate multiple receptor tyrosine kinases and regulate serine/threonine kinases to activate ERK in neuronal cells. British Journal of Pharmacology. 165: 2497-511. PMID 21518335 DOI: 10.1111/J.1476-5381.2011.01455.X  0.433
2011 Howlett AC, Reggio PH, Childers SR, Hampson RE, Ulloa NM, Deutsch DG. Endocannabinoid tone versus constitutive activity of cannabinoid receptors. British Journal of Pharmacology. 163: 1329-43. PMID 21545414 DOI: 10.1111/J.1476-5381.2011.01364.X  0.536
2010 Pertwee RG, Howlett AC, Abood ME, Alexander SP, Di Marzo V, Elphick MR, Greasley PJ, Hansen HS, Kunos G, Mackie K, Mechoulam R, Ross RA. International Union of Basic and Clinical Pharmacology. LXXIX. Cannabinoid receptors and their ligands: beyond CB₁ and CBâ‚‚. Pharmacological Reviews. 62: 588-631. PMID 21079038 DOI: 10.1124/Pr.110.003004  0.505
2010 Skelly MJ, Guy EG, Howlett AC, Pratt WE. CB1 receptors modulate the intake of a sweetened-fat diet in response to μ-opioid receptor stimulation of the nucleus accumbens. Pharmacology, Biochemistry, and Behavior. 97: 144-51. PMID 20562021 DOI: 10.1016/J.Pbb.2010.05.024  0.46
2010 Howlett AC, Blume LC, Dalton GD. CB(1) cannabinoid receptors and their associated proteins. Current Medicinal Chemistry. 17: 1382-93. PMID 20166926 DOI: 10.2174/092986710790980023  0.51
2009 Dalton GD, Bass CE, Van Horn CG, Howlett AC. Signal transduction via cannabinoid receptors. Cns & Neurological Disorders Drug Targets. 8: 422-31. PMID 19839935 DOI: 10.2174/187152709789824615  0.761
2009 Carney ST, Lloyd ML, MacKinnon SE, Newton DC, Jones JD, Howlett AC, Norford DC. Cannabinoid regulation of nitric oxide synthase I (nNOS) in neuronal cells. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 4: 338-49. PMID 19365734 DOI: 10.1007/S11481-009-9153-7  0.448
2008 Gerald TM, Howlett AC, Ward GR, Ho C, Franklin SO. Gene expression of opioid and dopamine systems in mouse striatum: effects of CB1 receptors, age and sex. Psychopharmacology. 198: 497-508. PMID 18438728 DOI: 10.1007/S00213-008-1141-8  0.488
2008 Padgett LW, Howlett AC, Shim JY. Binding mode prediction of conformationally restricted anandamide analogs within the CB1 receptor. Journal of Molecular Signaling. 3: 5. PMID 18302793 DOI: 10.1186/1750-2187-3-5  0.496
2008 Jones JD, Carney ST, Vrana KE, Norford DC, Howlett AC. Cannabinoid receptor-mediated translocation of NO-sensitive guanylyl cyclase and production of cyclic GMP in neuronal cells. Neuropharmacology. 54: 23-30. PMID 17707868 DOI: 10.1016/J.Neuropharm.2007.06.027  0.474
2007 Niehaus JL, Liu Y, Wallis KT, Egertová M, Bhartur SG, Mukhopadhyay S, Shi S, He H, Selley DE, Howlett AC, Elphick MR, Lewis DL. CB1 cannabinoid receptor activity is modulated by the cannabinoid receptor interacting protein CRIP 1a. Molecular Pharmacology. 72: 1557-66. PMID 17895407 DOI: 10.1124/Mol.107.039263  0.516
2007 Anavi-Goffer S, Fleischer D, Hurst DP, Lynch DL, Barnett-Norris J, Shi S, Lewis DL, Mukhopadhyay S, Howlett AC, Reggio PH, Abood ME. Helix 8 Leu in the CB1 cannabinoid receptor contributes to selective signal transduction mechanisms. The Journal of Biological Chemistry. 282: 25100-13. PMID 17595161 DOI: 10.1074/Jbc.M703388200  0.495
2007 Ward GR, Franklin SO, Gerald TM, Dempsey KT, Clodfelter DE, Krissinger DJ, Patel KM, Vrana KE, Howlett AC. Glucocorticoids plus opioids up-regulate genes that influence neuronal function. Cellular and Molecular Neurobiology. 27: 651-60. PMID 17554624 DOI: 10.1007/S10571-007-9151-3  0.43
2007 Grace CR, Cowsik SM, Shim JY, Welsh WJ, Howlett AC. Unique helical conformation of the fourth cytoplasmic loop of the CB1 cannabinoid receptor in a negatively charged environment. Journal of Structural Biology. 159: 359-68. PMID 17524664 DOI: 10.1016/J.Jsb.2007.04.004  0.376
2007 McCollum L, Howlett AC, Mukhopadhyay S. Anandamide-mediated CB1/CB2 cannabinoid receptor--independent nitric oxide production in rabbit aortic endothelial cells. The Journal of Pharmacology and Experimental Therapeutics. 321: 930-7. PMID 17379772 DOI: 10.1124/Jpet.106.117549  0.441
2006 Howlett AC, Mukhopadhyay S, Norford DC. Endocannabinoids and reactive nitrogen and oxygen species in neuropathologies. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 1: 305-16. PMID 18040807 DOI: 10.1007/S11481-006-9022-6  0.333
2006 Mukhopadhyay S, Das S, Williams EA, Moore D, Jones JD, Zahm DS, Ndengele MM, Lechner AJ, Howlett AC. Lipopolysaccharide and cyclic AMP regulation of CB(2) cannabinoid receptor levels in rat brain and mouse RAW 264.7 macrophages. Journal of Neuroimmunology. 181: 82-92. PMID 17045344 DOI: 10.1016/J.Jneuroim.2006.08.002  0.507
2006 Shim JY, Howlett AC. WIN55212-2 docking to the CB1 cannabinoid receptor and multiple pathways for conformational induction. Journal of Chemical Information and Modeling. 46: 1286-300. PMID 16711748 DOI: 10.1021/Ci0504824  0.475
2006 Gerald TM, Ward GR, Howlett AC, Franklin SO. CB1 knockout mice display significant changes in striatal opioid peptide and D4 dopamine receptor gene expression. Brain Research. 1093: 20-4. PMID 16684513 DOI: 10.1016/J.Brainres.2006.03.088  0.537
2005 Howlett AC. Cannabinoid receptor signaling Handbook of Experimental Pharmacology. 168: 53-79. PMID 16596771 DOI: 10.1007/3-540-26573-2_2  0.513
2005 Howlett AC. A short guide to the nomenclature of seven-transmembrane spanning receptors for lipid mediators. Life Sciences. 77: 1522-30. PMID 15953619 DOI: 10.1016/J.Lfs.2005.05.003  0.464
2005 Mukhopadhyay S, Howlett AC. Chemically distinct ligands promote differential CB1 cannabinoid receptor-Gi protein interactions. Molecular Pharmacology. 67: 2016-24. PMID 15749995 DOI: 10.1124/Mol.104.003558  0.447
2004 Howlett AC, Breivogel CS, Childers SR, Deadwyler SA, Hampson RE, Porrino LJ. Cannabinoid physiology and pharmacology: 30 years of progress. Neuropharmacology. 47: 345-58. PMID 15464149 DOI: 10.1016/J.Neuropharm.2004.07.030  0.526
2004 Howlett AC. Efficacy in CB1 receptor-mediated signal transduction. British Journal of Pharmacology. 142: 1209-18. PMID 15308578 DOI: 10.1038/Sj.Bjp.0705881  0.516
2004 Shim JY, Howlett AC. Steric trigger as a mechanism for CB1 cannabinoid receptor activation. Journal of Chemical Information and Computer Sciences. 44: 1466-76. PMID 15272855 DOI: 10.1021/Ci040040C  0.44
2003 Shim JY, Welsh WJ, Howlett AC. Homology model of the CB1 cannabinoid receptor: sites critical for nonclassical cannabinoid agonist interaction. Biopolymers. 71: 169-89. PMID 12767117 DOI: 10.1002/Bip.10424  0.466
2002 Mukhopadhyay S, Shim JY, Assi AA, Norford D, Howlett AC. CB(1) cannabinoid receptor-G protein association: a possible mechanism for differential signaling. Chemistry and Physics of Lipids. 121: 91-109. PMID 12505694 DOI: 10.1016/S0009-3084(02)00153-6  0.494
2002 Howlett AC. The cannabinoid receptors. Prostaglandins & Other Lipid Mediators. 68: 619-31. PMID 12432948 DOI: 10.1016/S0090-6980(02)00060-6  0.516
2002 Howlett AC, Barth F, Bonner TI, Cabral G, Casellas P, Devane WA, Felder CC, Herkenham M, Mackie K, Martin BR, Mechoulam R, Pertwee RG. International Union of Pharmacology. XXVII. Classification of cannabinoid receptors. Pharmacological Reviews. 54: 161-202. PMID 12037135 DOI: 10.1124/Pr.54.2.161  0.652
2002 Mukhopadhyay S, Chapnick BM, Howlett AC. Anandamide-induced vasorelaxation in rabbit aortic rings has two components: G protein dependent and independent. American Journal of Physiology. Heart and Circulatory Physiology. 282: H2046-54. PMID 12003810 DOI: 10.1152/Ajpheart.00497.2001  0.453
2002 Shim JY, Welsh WJ, Cartier E, Edwards JL, Howlett AC. Molecular interaction of the antagonist N-(piperidin-1-yl)-5-(4-chlorophenyl)-1- (2,4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide with the CB1 cannabinoid receptor. Journal of Medicinal Chemistry. 45: 1447-59. PMID 11906286 DOI: 10.1021/Jm010267O  0.456
2001 Meschler JP, Howlett AC, Madras BK. Cannabinoid receptor agonist and antagonist effects on motor function in normal and 1-methyl-4-phenyl-1,2,5,6-tetrahydropyridine (MPTP)-treated non-human primates. Psychopharmacology. 156: 79-85. PMID 11465637 DOI: 10.1007/S002130100728  0.781
2001 Hudson TY, Corbett JA, Howlett AC, Klein C. Nitric oxide regulates adenylyl cyclase activity in rat striatal membranes Journal of Neurochemistry. 77: 1279-1284. PMID 11389178 DOI: 10.1046/J.1471-4159.2001.00331.X  0.395
2001 Meschler JP, Howlett AC. Signal transduction interactions between CB1 cannabinoid and dopamine receptors in the rat and monkey striatum. Neuropharmacology. 40: 918-26. PMID 11378162 DOI: 10.1016/S0028-3908(01)00012-0  0.798
2001 Mukhopadhyay S, Howlett AC. CB1 receptor-G protein association: Subtype selectivity is determined by distinct intracellular domains European Journal of Biochemistry. 268: 499-505. PMID 11168387 DOI: 10.1046/J.1432-1327.2001.01810.X  0.506
2000 Meschler JP, Conley TJ, Howlett AC. Cannabinoid and dopamine interaction in rodent brain: effects on locomotor activity. Pharmacology, Biochemistry, and Behavior. 67: 567-73. PMID 11164087 DOI: 10.1016/S0091-3057(00)00390-7  0.788
2000 Howlett AC, Mukhopadhyay S. Cellular signal transduction by anandamide and 2-arachidonoylglycerol Chemistry and Physics of Lipids. 108: 53-70. PMID 11106782 DOI: 10.1016/S0009-3084(00)00187-0  0.489
2000 Meschler JP, Kraichely DM, Wilken GH, Howlett AC. Inverse agonist properties of N-(piperidin-1-yl)-5-(4-chlorophenyl)-1-(2, 4-dichlorophenyl)-4-methyl-1H-pyrazole-3-carboxamide HCl (SR141716A) and 1-(2-chlorophenyl)-4-cyano-5-(4-methoxyphenyl)-1H-pyrazole-3-carboxyl ic acid phenylamide (CP-272871) for the CB(1) cannabinoid receptor. Biochemical Pharmacology. 60: 1315-23. PMID 11008125 DOI: 10.1016/S0006-2952(00)00447-0  0.795
2000 Berglund BA, Fleming PR, Rice KC, Shim JY, Welsh WJ, Howlett AC. Development of a novel class of monocyclic and bicyclic alkyl amides that exhibit CB1 and CB2 cannabinoid receptor affinity and receptor activation. Drug Design and Discovery. 16: 281-94. PMID 10807034  0.396
2000 Howlett AC, Wilken GH, Pigg JJ, Houston DB, Lan R, Liu Q, Makriyannis A. Azido- and isothiocyanato-substituted aryl pyrazoles bind covalently to the CB1 cannabinoid receptor and impair signal transduction. Journal of Neurochemistry. 74: 2174-81. PMID 10800963 DOI: 10.1046/J.1471-4159.2000.0742174.X  0.505
2000 Hill J, Howlett A, Klein C. Nitric oxide selectively inhibits adenylyl cyclase isoforms 5 and 6 Cellular Signalling. 12: 233-237. PMID 10781930 DOI: 10.1016/S0898-6568(99)00082-0  0.313
2000 Meschler JP, Clarkson FA, Mathews PJ, Howlett AC, Madras BK. D(2), but not D(1) dopamine receptor agonists potentiate cannabinoid-induced sedation in nonhuman primates. The Journal of Pharmacology and Experimental Therapeutics. 292: 952-9. PMID 10688609  0.796
2000 Mukhopadhyay S, McIntosh HH, Houston DB, Howlett AC. The CB(1) cannabinoid receptor juxtamembrane C-terminal peptide confers activation to specific G proteins in brain. Molecular Pharmacology. 57: 162-70. PMID 10617691  0.377
1999 Berglund BA, Boring DL, Howlett AC. Investigation of structural analogs of prostaglandin amides for binding to and activation of CB1 and CB2 cannabinoid receptors in rat brain and human tonsils. Advances in Experimental Medicine and Biology. 469: 527-33. PMID 10667378 DOI: 10.1007/978-1-4615-4793-8_77  0.477
1999 Howlett AC, Mukhopadhyay S, Shim JY, Welsh WJ. Signal transduction of eicosanoid CB1 receptor ligands Life Sciences. 65: 617-625. PMID 10462062 DOI: 10.1016/S0024-3205(99)00284-2  0.513
1999 McVey M, Hill J, Howlett A, Klein C. Adenylyl cyclase, a coincidence detector for nitric oxide. The Journal of Biological Chemistry. 274: 18887-92. PMID 10383385 DOI: 10.1074/Jbc.274.27.18887  0.311
1999 Meschler JP, Howlett AC. Thujone exhibits low affinity for cannabinoid receptors but fails to evoke cannabimimetic responses. Pharmacology, Biochemistry, and Behavior. 62: 473-80. PMID 10080239 DOI: 10.1016/S0091-3057(98)00195-6  0.8
1999 Mukhopadhyay S, Cowsik SM, Lynn AM, Welsh WJ, Howlett AC. Regulation of G(i) by the CB1 cannabinoid receptor C-terminal juxtamembrane region: Structural requirements determined by peptide analysis Biochemistry. 38: 3447-3455. PMID 10079092 DOI: 10.1021/Bi981767V  0.338
1999 Shim JY, Collantes ER, Welsh WJ, Howlett AC. Unified pharmacophoric model for cannabinoids and aminoalkylindoles derived from molecular superimposition of CB1 cannabinoid receptor agonists CP55244 and WIN55212-2 Acs Symposium Series. 719: 165-184.  0.339
1998 Howlett AC. The CB1 cannabinoid receptor in the brain Neurobiology of Disease. 5: 405-416. PMID 9974174 DOI: 10.1006/Nbdi.1998.0215  0.519
1998 Ruh MF, Bi Y, Cox L, Berk D, Howlett AC, Bellone CJ. Effect of environmental estrogens on IL-1beta promoter activity in a macrophage cell line. Endocrine. 9: 207-11. PMID 9867255 DOI: 10.1385/Endo:9:2:207  0.322
1998 Shim JY, Collantes ER, Welsh WJ, Subramaniam B, Howlett AC, Eissenstat MA, Ward SJ. Three-dimensional quantitative structure-activity relationship study of the cannabimimetic (aminoalkyl)indoles using comparative molecular field analysis. Journal of Medicinal Chemistry. 41: 4521-32. PMID 9804691 DOI: 10.1021/Jm980305C  0.387
1998 Houston DB, Howlett AC. Differential receptor-G-protein coupling evoked by dissimilar cannabinoid receptor agonists. Cellular Signalling. 10: 667-74. PMID 9794249 DOI: 10.1016/S0898-6568(98)00013-8  0.507
1998 Tong W, Collantes ER, Welsh WJ, Berglund BA, Howlett AC. Derivation of a pharmacophore model for anandamide using constrained conformational searching and comparative molecular field analysis. Journal of Medicinal Chemistry. 41: 4207-15. PMID 9784095 DOI: 10.1021/Jm970239Z  0.353
1998 Berglund BA, Boring DL, Wilken GH, Makriyannis A, Howlett AC, Lin S. Structural requirements for arachidonylethanolamide interaction with CB1 and CB2 cannabinoid receptors: pharmacology of the carbonyl and ethanolamide groups. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 59: 111-8. PMID 9774174 DOI: 10.1016/S0952-3278(98)90089-8  0.497
1998 Howlett AC, Song C, Berglund BA, Wilken GH, Pigg JJ. Characterization of CB1 cannabinoid receptors using receptor peptide fragments and site-directed antibodies. Molecular Pharmacology. 53: 504-10. PMID 9495818 DOI: 10.1124/Mol.53.3.504  0.416
1998 McIntosh HH, Song C, Howlett AC. CB1 cannabinoid receptor: cellular regulation and distribution in N18TG2 neuroblastoma cells. Brain Research. Molecular Brain Research. 53: 163-73. PMID 9473654 DOI: 10.1016/S0169-328X(97)00294-5  0.505
1997 Deutsch DG, Omeir R, Arreaza G, Salehani D, Prestwich GD, Huang Z, Howlett A. Methyl arachidonyl fluorophosphonate: a potent irreversible inhibitor of anandamide amidase. Biochemical Pharmacology. 53: 255-60. PMID 9065728 DOI: 10.1016/S0006-2952(96)00830-1  0.418
1997 Ruh MF, Taylor JA, Howlett AC, Welshons WV. Failure of cannabinoid compounds to stimulate estrogen receptors Biochemical Pharmacology. 53: 35-41. PMID 8960061 DOI: 10.1016/S0006-2952(96)00659-4  0.457
1996 Boring DL, Berglund BA, Howlett AC. Cerebrodiene, arachidonyl-ethanolamide, and hybrid structures: potential for interaction with brain cannabinoid receptors. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 55: 207-10. PMID 8931121 DOI: 10.1016/S0952-3278(96)90100-3  0.465
1996 Tao Y, Howlett A, Klein C. Nitric oxide inhibits the initiation of cAMP pulsing in D. discoideum without altering receptor-activated adenylate cyclase. Cellular Signalling. 8: 26-34. PMID 8777138 DOI: 10.1016/0898-6568(95)02011-X  0.451
1996 Yamada K, Rice KC, Flippen-Anderson JL, Eissenstat MA, Ward SJ, Johnson MR, Howlett AC. (Aminoalkyl)indole isothiocyanates as potential electrophilic affinity ligands for the brain cannabinoid receptor. Journal of Medicinal Chemistry. 39: 1967-74. PMID 8642555 DOI: 10.1021/jm950932r  0.304
1995 Melvin LS, Milne GM, Johnson MR, Wilken GH, Howlett AC. Structure-activity relationships defining the ACD-tricyclic cannabinoids: cannabinoid receptor binding and analgesic activity. Drug Design and Discovery. 13: 155-66. PMID 8872458  0.359
1995 Song C, Howlett AC. Rat brain cannabinoid receptors are N-linked glycosylated proteins Life Sciences. 56: 1983-1989. PMID 7776822 DOI: 10.1016/0024-3205(95)00179-A  0.434
1995 Belue RC, Howlett AC, Westlake TM, Hutchings DE. The ontogeny of cannabinoid receptors in the brain of postnatal and aging rats Neurotoxicology and Teratology. 17: 25-30. PMID 7708016 DOI: 10.1016/0892-0362(94)00053-G  0.489
1995 Howlett AC. Pharmacology of cannabinoid receptors Annual Review of Pharmacology and Toxicology. 35: 607-634. PMID 7598509 DOI: 10.1146/Annurev.Pa.35.040195.003135  0.541
1994 Evans DM, Lake JT, Johnson MR, Howlett AC. Endogenous cannabinoid receptor binding activity released from rat brain slices by depolarization Journal of Pharmacology and Experimental Therapeutics. 268: 1271-1277. PMID 8138940  0.394
1994 Tao Y, Howlett A, Klein C. Nitric oxide regulation of glyceraldehyde-3-phosphate dehydrogenase activity in Dictyostelium discoideum cells and lysates. European Journal of Biochemistry. 224: 447-54. PMID 7925359 DOI: 10.1111/J.1432-1033.1994.00447.X  0.301
1994 Westlake TM, Howlett AC, Bonner TI, Matsuda LA, Herkenham M. Cannabinoid receptor binding and messenger RNA expression in human brain: an in vitro receptor autoradiography and in situ hybridization histochemistry study of normal aged and Alzheimer's brains. Neuroscience. 63: 637-52. PMID 7898667 DOI: 10.1016/0306-4522(94)90511-8  0.412
1994 Martin BR, Childers S, Howlett A, Mechoulam R, Pertwee R. Cannabinoid receptors: Pharmacology, second messenger systems and endogenous ligands Nida Research Monograph Series. 55-60.  0.337
1993 Houston DB, Howlett AC. Solubilization of the cannabinoid receptor from rat brain and its functional interaction with guanine nucleotide-binding proteins. Molecular Pharmacology. 43: 17-22. PMID 8423766  0.417
1993 Melvin LS, Milne GM, Johnson MR, Subramaniam B, Wilken GH, Howlett AC. Structure-activity relationships for cannabinoid receptor-binding and analgesic activity: studies of bicyclic cannabinoid analogs. Molecular Pharmacology. 44: 1008-15. PMID 8246904  0.391
1993 Wessels-Reiker M, Basiboina R, Howlett AC, Strong R. Vasoactive intestinal polypeptide-related peptides modulate tyrosine hydroxylase gene expression in PC12 cells through multiple adenylate cyclase-coupled receptors. Journal of Neurochemistry. 60: 1018-29. PMID 8094740 DOI: 10.1111/J.1471-4159.1993.Tb03250.X  0.349
1993 Tao Y, Howlett AC, Klein C. Endogenous ADP-ribosylation of glyceraldehyde-3-phosphate dehydrogenase that is not regulated by nitric oxide in Dictyostelium discoideum Cellular Signalling. 5: 763-775. PMID 7907497 DOI: 10.1016/0898-6568(93)90037-M  0.3
1992 Houston DB, Howlett AC. Solubilization of the cannabinoid receptor from rat brain membranes. Annals of the New York Academy of Sciences. 654: 448-50. PMID 1632600 DOI: 10.1111/J.1749-6632.1992.Tb25994.X  0.41
1992 Tao Y, Howlett A, Klein C. Nitric oxide-releasing compounds inhibit Dictyostelium discoideum aggregation without altering cGMP production. Febs Letters. 314: 49-52. PMID 1360411 DOI: 10.1016/0014-5793(92)81459-Y  0.341
1992 Charalambous A, Yan G, Houston DB, Howlett AC, Compton DR, Martin BR, Makriyannis A. 5'-Azido-delta 8-THC: a novel photoaffinity label for the cannabinoid receptor. Journal of Medicinal Chemistry. 35: 3076-9. PMID 1323683 DOI: 10.1021/Jm00094A023  0.595
1991 Courtney ND, Howlett AC, Westfall TC. Regulation of nicotine-evoked dopamine release from PC12 cells. Life Sciences. 48: 1671-8. PMID 1850061 DOI: 10.1016/0024-3205(91)90127-W  0.328
1991 Courtney ND, Howlett AC, Westfall TC. Dopaminergic regulation of dopamine release from PC12 cells via a pertussis toxin-sensitive G protein. Neuroscience Letters. 122: 261-4. PMID 1827517 DOI: 10.1016/0304-3940(91)90873-R  0.39
1991 Howlett AC, Champion-Dorow TM, McMahon LL, Westlake TM. The cannabinoid receptor: biochemical and cellular properties in neuroblastoma cells. Pharmacology, Biochemistry, and Behavior. 40: 565-9. PMID 1806946 DOI: 10.1016/0091-3057(91)90364-8  0.563
1991 Bidaut-Russell M, Howlett AC. Cannabinoid receptor-regulated cyclic AMP accumulation in the rat striatum. Journal of Neurochemistry. 57: 1769-73. PMID 1681035 DOI: 10.1111/j.1471-4159.1991.tb06379.x  0.422
1991 Wessels-Reiker M, Haycock JW, Howlett AC, Strong R. Vasoactive intestinal polypeptide induces tyrosine hydroxylase in PC12 cells Journal of Biological Chemistry. 266: 9347-9350. PMID 1674510  0.307
1991 O'Donnell KA, Howlett AC. Inhibition of adenylate cyclase by p-bromophenacyl bromide Biochemical Pharmacology. 42: 1941-1946. PMID 1660272 DOI: 10.1016/0006-2952(91)90593-T  0.35
1991 O'Donnell KA, Howlett AC. Muscarinic receptor binding is inhibited by quinacrine Neuroscience Letters. 127: 46-48. PMID 1652714 DOI: 10.1016/0304-3940(91)90891-V  0.459
1991 Westlake TM, Howlett AC, Ali SF, Paule MG, Scallet AC, Slikker W. Chronic exposure to delta 9-tetrahydrocannabinol fails to irreversibly alter brain cannabinoid receptors. Brain Research. 544: 145-9. PMID 1649662 DOI: 10.1016/0006-8993(91)90897-5  0.41
1990 Howlett AC. Reverse pharmacology applied to the cannabinoid receptor Trends in Pharmacological Sciences. 11: 395-397. PMID 2256177 DOI: 10.1016/0165-6147(90)90142-U  0.532
1990 Coezy ED, Corvol P, Howlett AC. Involvement of a pertussis toxin-sensitive G protein in the regulation of angiotensinogen production by an angiotensin II analog in HepG2 cells Cellular Signalling. 2: 67-76. PMID 2176801 DOI: 10.1016/0898-6568(90)90034-8  0.354
1990 Bidaut‐Russell M, Devane WA, Howlett AC. Cannabinoid Receptors and Modulation of Cyclic AMP Accumulation in the Rat Brain Journal of Neurochemistry. 55: 21-26. PMID 2162376 DOI: 10.1111/J.1471-4159.1990.Tb08815.X  0.41
1990 Howlett AC, Champion TM, Wilken GH, Mechoulam R. Stereochemical effects of 11-OH-Δ8-tetrahydrocannabinol-dimethylheptyl to inhibit adenylate cyclase and bind to the cannabinoid receptor Neuropharmacology. 29: 161-165. PMID 2158635 DOI: 10.1016/0028-3908(90)90056-W  0.466
1990 Howlett AC, Bidaut-Russell M, Devane WA, Melvin LS, Johnson MR, Herkenham M. The cannabinoid receptor: biochemical, anatomical and behavioral characterization. Trends in Neurosciences. 13: 420-3. PMID 1700516 DOI: 10.1016/0166-2236(90)90124-S  0.494
1989 Howlett AC, Scott DK, Wilken GH. Regulation of adenylate cyclase by cannabinoid drugs. Insights based on thermodynamic studies Biochemical Pharmacology. 38: 3297-3304. PMID 2554920 DOI: 10.1016/0006-2952(89)90628-X  0.335
1988 Howlett AC, Johnson MR, Melvin LS, Milne GM. Nonclassical cannabinoid analgetics inhibit adenylate cyclase: development of a cannabinoid receptor model. Molecular Pharmacology. 33: 297-302. PMID 3352594  0.44
1988 Khachatrian L, Klein C, Howlett A. Pertussis and cholera toxin ADP-ribosylation in Dictyostelium discoideum membranes. Biochemical and Biophysical Research Communications. 149: 975-81. PMID 3122750 DOI: 10.1016/0006-291X(87)90504-3  0.396
1988 Devane WA, Dysarz FA, Johnson MR, Melvin LS, Howlett AC. Determination and characterization of a cannabinoid receptor in rat brain. Molecular Pharmacology. 34: 605-13. PMID 2848184  0.319
1987 Howlett AC. Cannabinoid inhibition of adenylate cyclase: Relative activity of constituents and metabolites of marihuana Neuropharmacology. 26: 507-512. PMID 3601007 DOI: 10.1016/0028-3908(87)90035-9  0.319
1987 Walz MA, Holt IL, Howlett AC. Cyclic nucleotide phosphodiesterase isozymes in neuroblastoma cells Journal of Neuroscience Research. 17: 291-297. PMID 3037096 DOI: 10.1002/Jnr.490170314  0.317
1987 Khachatrian L, Klein C, Howlett A. Regulation of Dictyostelium discoideum adenylate cyclase by manganese and adenosine analogs. Biochimica Et Biophysica Acta. 927: 235-46. PMID 2880607 DOI: 10.1016/0167-4889(87)90140-6  0.379
1987 Bidaut-Russell M, Howlett AC. Muscarinic pharmacology of the inhibition of adenylate cyclase in N18TG2 neuroblastoma cells Neurochemistry International. 11: 287-292. DOI: 10.1016/0197-0186(87)90048-9  0.441
1986 Devane WA, Spain JW, Coscia CJ, Howlett AC. An assessment of the role of opioid receptors in the response to cannabimimetic drugs. Journal of Neurochemistry. 46: 1929-35. PMID 3009717 DOI: 10.1111/J.1471-4159.1986.Tb08515.X  0.413
1985 Brick PL, Howlett AC, Beinfeld MC. Synthesis and release of vasoactive intestinal polypeptide (VIP) by mouse neuroblastoma cells: modulation by cyclic nucleotides and ascorbic acid. Peptides. 6: 1075-8. PMID 3010255 DOI: 10.1016/0196-9781(85)90430-9  0.314
1984 Roth BL, Beinfeld MC, Howlett AC. Secretin Receptors on Neuroblastoma Cell Membranes: Characterization of 125I‐Labeled Secretin Binding and Association with Adenylate Cyclase Journal of Neurochemistry. 42: 1145-1152. PMID 6321661 DOI: 10.1111/J.1471-4159.1984.Tb12723.X  0.417
1984 Howlett AC, Fleming RM. Cannabinoid inhibition of adenylate cyclase. Pharmacology of the response in neuroblastoma cell membrane Molecular Pharmacology. 26: 532-538. PMID 6092901  0.34
1984 Howlett AC. Inhibition of neuroblastoma adenylate cyclase by cannabinoid and nantradol compounds Life Sciences. 35: 1803-1810. PMID 6090851 DOI: 10.1016/0024-3205(84)90278-9  0.395
1982 Howlett AC. Stimulation of neuroblastoma adenylate cyclase by arachidonic acid metabolites Molecular Pharmacology. 21: 664-670. PMID 6287201  0.352
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