| Year |
Citation |
Score |
| 2013 |
Yi B, Long S, González-Cestari TF, Henderson BJ, Pavlovicz RE, Werbovetz K, Li C, McKay DB. Discovery of benzamide analogs as negative allosteric modulators of human neuronal nicotinic receptors: pharmacophore modeling and structure-activity relationship studies. Bioorganic & Medicinal Chemistry. 21: 4730-43. PMID 23757208 DOI: 10.1016/J.Bmc.2013.03.082 |
0.694 |
|
| 2013 |
Still PC, Yi B, González-Cestari TF, Pan L, Pavlovicz RE, Chai HB, Ninh TN, Li C, Soejarto DD, McKay DB, Kinghorn AD. Alkaloids from Microcos paniculata with cytotoxic and nicotinic receptor antagonistic activities. Journal of Natural Products. 76: 243-9. PMID 23327794 DOI: 10.1021/Np3007414 |
0.698 |
|
| 2012 |
Henderson BJ, González-Cestari TF, Yi B, Pavlovicz RE, Boyd RT, Li C, Bergmeier SC, McKay DB. Defining the putative inhibitory site for a selective negative allosteric modulator of human α4β2 neuronal nicotinic receptors. Acs Chemical Neuroscience. 3: 682-92. PMID 23019495 DOI: 10.1021/Cn300035F |
0.68 |
|
| 2012 |
Henderson BJ, Orac CM, Maciagiewicz I, Bergmeier SC, McKay DB. 3D-QSAR and 3D-QSSR models of negative allosteric modulators facilitate the design of a novel selective antagonist of human α4β2 neuronal nicotinic acetylcholine receptors. Bioorganic & Medicinal Chemistry Letters. 22: 1797-813. PMID 22285942 DOI: 10.1016/J.Bmcl.2011.11.051 |
0.546 |
|
| 2011 |
Mahasenan KV, Pavlovicz RE, Henderson BJ, González-Cestari TF, Yi B, McKay DB, Li C. Discovery of Novel α4β2 Neuronal Nicotinic Receptor Modulators through Structure-Based Virtual Screening. Acs Medicinal Chemistry Letters. 2: 855-60. PMID 24936233 DOI: 10.1021/Ml2001714 |
0.663 |
|
| 2011 |
Henderson BJ, Carper DJ, González-Cestari TF, Yi B, Mahasenan K, Pavlovicz RE, Dalefield ML, Coleman RS, Li C, McKay DB. Structure-activity relationship studies of sulfonylpiperazine analogues as novel negative allosteric modulators of human neuronal nicotinic receptors. Journal of Medicinal Chemistry. 54: 8681-92. PMID 22060139 DOI: 10.1021/Jm201294R |
0.719 |
|
| 2011 |
Pavlovicz RE, Henderson BJ, Bonnell AB, Boyd RT, McKay DB, Li C. Identification of a negative allosteric site on human α4β2 and α3β4 neuronal nicotinic acetylcholine receptors. Plos One. 6: e24949. PMID 21949802 DOI: 10.1371/Journal.Pone.0024949 |
0.526 |
|
| 2011 |
Potaros T, Phornchirasilp S, McKay SB, González-Cestari TF, Boyd RT, McKay DB. Evidence for the involvement of adenomatous polyposis coli (APC) protein in maintaining cellular distributions of α3β4 nicotinic receptors. Neuroscience Letters. 489: 105-9. PMID 21138757 DOI: 10.1016/J.Neulet.2010.11.075 |
0.513 |
|
| 2010 |
Henderson BJ, Pavlovicz RE, Allen JD, González-Cestari TF, Orac CM, Bonnell AB, Zhu MX, Boyd RT, Li C, Bergmeier SC, McKay DB. Negative allosteric modulators that target human alpha4beta2 neuronal nicotinic receptors. The Journal of Pharmacology and Experimental Therapeutics. 334: 761-74. PMID 20551292 DOI: 10.1124/Jpet.110.168211 |
0.542 |
|
| 2009 |
González-Cestari TF, Henderson BJ, Pavlovicz RE, McKay SB, El-Hajj RA, Pulipaka AB, Orac CM, Reed DD, Boyd RT, Zhu MX, Li C, Bergmeier SC, McKay DB. Effect of novel negative allosteric modulators of neuronal nicotinic receptors on cells expressing native and recombinant nicotinic receptors: implications for drug discovery. The Journal of Pharmacology and Experimental Therapeutics. 328: 504-15. PMID 18984653 DOI: 10.1124/Jpet.108.144576 |
0.589 |
|
| 2008 |
Huang J, Orac CM, McKay S, McKay DB, Bergmeier SC. The synthesis of 5-substituted ring E analogs of methyllycaconitine via the Suzuki-Miyaura cross-coupling reaction. Bioorganic & Medicinal Chemistry. 16: 3816-24. PMID 18272373 DOI: 10.1016/J.Bmc.2008.01.050 |
0.393 |
|
| 2007 |
El-Hajj RA, McKay SB, McKay DB. Pharmacological and immunological identification of native alpha7 nicotinic receptors: evidence for homomeric and heteromeric alpha7 receptors. Life Sciences. 81: 1317-22. PMID 17928008 DOI: 10.1016/J.Lfs.2007.08.039 |
0.46 |
|
| 2007 |
McKay DB, Chang C, González-Cestari TF, McKay SB, El-Hajj RA, Bryant DL, Zhu MX, Swaan PW, Arason KM, Pulipaka AB, Orac CM, Bergmeier SC. Analogs of methyllycaconitine as novel noncompetitive inhibitors of nicotinic receptors: pharmacological characterization, computational modeling, and pharmacophore development. Molecular Pharmacology. 71: 1288-97. PMID 17308033 DOI: 10.1124/Mol.106.033233 |
0.496 |
|
| 2006 |
Free RB, Kaser DJ, Boyd RT, McKay DB. Receptor protection studies comparing recombinant and native nicotinic receptors: Evidence for a subpopulation of mecamylamine-sensitive native alpha3beta4* nicotinic receptors. Neuroscience Letters. 392: 135-9. PMID 16198480 DOI: 10.1016/J.Neulet.2005.09.002 |
0.78 |
|
| 2005 |
Free RB, McKay SB, Gottlieb PD, Boyd RT, McKay DB. Expression of native alpha3beta4* neuronal nicotinic receptors: binding and functional studies investigating turnover of surface and intracellular receptor populations. Molecular Pharmacology. 67: 2040-8. PMID 15772292 DOI: 10.1124/Mol.104.009282 |
0.764 |
|
| 2004 |
Bergmeier SC, Ismail KA, Arason KM, McKay S, Bryant DL, McKay DB. Structure activity studies of ring E analogues of methyllycaconitine. Part 2: Synthesis of antagonists to the alpha3beta4* nicotinic acetylcholine receptors through modifications to the ester. Bioorganic & Medicinal Chemistry Letters. 14: 3739-42. PMID 15203153 DOI: 10.1016/J.Bmcl.2004.05.001 |
0.542 |
|
| 2003 |
Zirger JM, Beattie CE, McKay DB, Boyd RT. Cloning and expression of zebrafish neuronal nicotinic acetylcholine receptors. Gene Expression Patterns : Gep. 3: 747-54. PMID 14643683 DOI: 10.1016/S1567-133X(03)00126-1 |
0.458 |
|
| 2003 |
Free RB, von Fischer ND, Boyd RT, McKay DB. Pharmacological characterization of recombinant bovine alpha3beta4 neuronal nicotinic receptors stably expressed in HEK 293 cells. Neuroscience Letters. 343: 180-4. PMID 12770692 DOI: 10.1016/S0304-3940(03)00381-1 |
0.707 |
|
| 2003 |
Free RB, McKay DB. Surface and intracellular nicotinic receptors expressed in intact adrenal chromaffin cells: direct measurements using [3H]epibatidine. Brain Research. 974: 60-9. PMID 12742624 DOI: 10.1016/S0006-8993(03)02551-4 |
0.698 |
|
| 2002 |
McKay DB, Free RB, Kaser DJ, McKay SB. Characterization of [(3)H]epibatidine binding to nicotinic receptors from bovine adrenal medulla. Annals of the New York Academy of Sciences. 971: 162-4. PMID 12438112 DOI: 10.1111/J.1749-6632.2002.Tb04456.X |
0.755 |
|
| 2002 |
Free RB, McKay SB, Boyd RT, McKay DB. Evidence for constitutive expression of bovine adrenal a3beta4* nicotinic acetylcholine receptors. Annals of the New York Academy of Sciences. 971: 145-7. PMID 12438106 DOI: 10.1111/J.1749-6632.2002.Tb04450.X |
0.754 |
|
| 2002 |
Bryant DL, Free RB, Thomasy SM, Lapinsky DJ, Ismail KA, Arason KM, Bergmeier SC, McKay DB. Effects of methyllycaconitine and related analogues on bovine adrenal alpha3beta4* nicotinic acetylcholine receptors. Annals of the New York Academy of Sciences. 971: 139-41. PMID 12438104 DOI: 10.1111/J.1749-6632.2002.Tb04448.X |
0.775 |
|
| 2002 |
Bryant DL, Free RB, Thomasy SM, Lapinsky DJ, Ismail KA, McKay SB, Bergmeier SC, McKay DB. Structure-activity studies with ring E analogues of methyllycaconitine on bovine adrenal alpha3beta4* nicotinic receptors. Neuroscience Research. 42: 57-63. PMID 11814609 DOI: 10.1016/S0168-0102(01)00304-2 |
0.744 |
|
| 2002 |
Free RB, Bryant DL, McKay SB, Kaser DJ, McKay DB. [3H]Epibatidine binding to bovine adrenal medulla: evidence for alpha3beta4* nicotinic receptors. Neuroscience Letters. 318: 98-102. PMID 11796195 DOI: 10.1016/S0304-3940(01)02489-2 |
0.766 |
|
| 2001 |
Free RB, McKay DB. Receptor protection studies to characterize neuronal nicotinic receptors: tubocurarine prevents alkylation of adrenal nicotinic receptors. Brain Research. 891: 176-84. PMID 11164821 DOI: 10.1016/S0006-8993(00)03204-2 |
0.787 |
|
| 2000 |
Free RB, Wenger BW, McKay DB. Effects of sulfhydryl modification on adrenal nicotinic acetylcholine receptors: disulfide integrity is not essential for activation. Life Sciences. 68: 373-85. PMID 11205888 DOI: 10.1016/S0024-3205(00)00943-7 |
0.778 |
|
| 1999 |
Bergmeier SC, Lapinsky DJ, Free RB, McKay DB. Ring E analogs of methyllycaconitine (MLA) as novel nicotinic antagonists. Bioorganic & Medicinal Chemistry Letters. 9: 2263-6. PMID 10465558 DOI: 10.1016/S0960-894X(99)00378-9 |
0.746 |
|
| 1998 |
Lopez I, McKay DB. Effects of antimitotic agents on secretion and detergent extractibility of adrenal nicotinic acetylcholine receptors. Cellular and Molecular Neurobiology. 17: 447-54. PMID 9353587 DOI: 10.1023/A:1026350619823 |
0.577 |
|
| 1997 |
Wenger BW, Bryant DL, Boyd RT, McKay DB. Evidence for spare nicotinic acetylcholine receptors and a beta 4 subunit in bovine adrenal chromaffin cells: studies using bromoacetylcholine, epibatidine, cytisine and mAb35. The Journal of Pharmacology and Experimental Therapeutics. 281: 905-13. PMID 9152400 |
0.799 |
|
| 1996 |
Gu H, Wenger BW, Lopez I, McKay SB, Boyd RT, McKay DB. Characterization and localization of adrenal nicotinic acetylcholine receptors: evidence that mAb35-nicotinic receptors are the principal receptors mediating adrenal catecholamine secretion. Journal of Neurochemistry. 66: 1454-61. PMID 8627298 DOI: 10.1046/J.1471-4159.1996.66041454.X |
0.792 |
|
| 1996 |
Maurer JA, Wenger BW, McKay DB. Effects of protein kinase inhibitors on morphology and function of cultured bovine adrenal chromaffin cells: KN-62 inhibits secretory function by blocking stimulated Ca2+ entry. Journal of Neurochemistry. 66: 105-13. PMID 8522941 DOI: 10.1046/J.1471-4159.1996.66010105.X |
0.735 |
|
| 1995 |
Maurer JA, Wenger BW, Guan Z, Stokes BT, McKay DB. Staurosporine affects calcium homeostasis in cultured bovine adrenal chromaffin cells. European Journal of Pharmacology. 288: 163-72. PMID 7720778 DOI: 10.1016/0922-4106(95)90191-4 |
0.72 |
|
| 1994 |
Maurer JA, McKay DB. Staurosporine-induced reduction of secretory function in cultured bovine adrenal chromaffin cells. European Journal of Pharmacology. 253: 115-24. PMID 8013537 DOI: 10.1016/0014-2999(94)90765-X |
0.465 |
|
| 1994 |
Gu H, Mckay SB, Burkman AM, Mckay DB. Comparison of the effects of antimitotic drugs on α-tubulin mRNA, microtubules and nicotinic receptor-mediated catecholamine secretion in adrenal chromaffin cells in culture General Pharmacology. 25: 439-446. PMID 7926588 DOI: 10.1016/0306-3623(94)90194-5 |
0.504 |
|
| 1993 |
Mckay DB, Burkman AM. Nicotinic and Nonnicotinic Receptor-Mediated Actions of Vinblastine Proceedings of the Society For Experimental Biology and Medicine. 203: 372-376. PMID 8516349 DOI: 10.3181/00379727-203-43614 |
0.508 |
|
| 1992 |
Maurer JA, McKay DB. Time-dependent inhibition of stimulated adrenal catecholamine release by staurosporine. Journal of Neurochemistry. 59: 1578-80. PMID 1402907 DOI: 10.1111/J.1471-4159.1992.Tb08479.X |
0.373 |
|
| 1991 |
McKay DB, Lopez I, Sanchez PA, English JL, Wallace LJ. Characterization of muscarinic receptors of bovine adrenal chromaffin cells: binding, secretion and anti-microtubule drug effects. General Pharmacology. 22: 1185-9. PMID 1810813 DOI: 10.1016/0306-3623(91)90599-2 |
0.58 |
|
| 1990 |
McKay DB, Trent-Sanchez P. Effect of noncompetitive nicotinic receptor blockers on catecholamine release from cultured adrenal chromaffin cells Pharmacology. 40: 224-230. PMID 1697077 DOI: 10.1159/000138663 |
0.523 |
|
| 1989 |
McKay DB. [3H]Noradrenaline accumulation in cultured bovine adrenal medullary cells: modulation of accumulation by nicotine Naunyn-Schmiedeberg's Archives of Pharmacology. 340: 610-616. PMID 2615853 DOI: 10.1007/Bf00717735 |
0.469 |
|
| 1989 |
McKay DB. Structure-activity study on the actions of taxol and related taxanes on primary cultures of adrenal medullary cells Journal of Pharmacology and Experimental Therapeutics. 248: 1302-1307. PMID 2564892 |
0.427 |
|
| 1987 |
McKay DB, Cobianchi MJ, Schneider AS. Comparison of the effects of colchicine and beta-lumicolchicine on cultured adrenal chromaffin cells: Lack of evidence for an action of colchicine on receptor-associated microtubules Pharmacology. 35: 155-162. PMID 3685083 DOI: 10.1159/000138307 |
0.46 |
|
| 1985 |
McKay DB, Aronstam RS, Schneider AS. Interactions of microtubule-active agents with nicotinic-acetylcholine receptors. Relationship to their inhibition of catecholamine secretion by adrenal chromaffin cells Molecular Pharmacology. 28: 10-16. PMID 2410767 |
0.412 |
|
| 1984 |
McKay DB, Schneider AS. Selective inhibition of cholinergic receptor-mediated 45Ca++ uptake and catecholamine secretion from adrenal chromaffin cells by taxol and vinblastine Journal of Pharmacology and Experimental Therapeutics. 231: 102-108. PMID 6149300 |
0.414 |
|
| 1984 |
McKay DB, Aronstam RS, Schneider AS. Interaction of microtubule-active drugs with the torpedo nicotinic receptor: Correlations with effects on adrenal catecholamine secretion and 45Ca++ uptake Federation Proceedings. 43. |
0.405 |
|
| Show low-probability matches. |