Angelo C. Lepore, Ph.D. - Publications

Affiliations: 
2005 Drexel University College of Medicine, Philadelphia, PA, United States 
Area:
Neuroscience Biology, Cell Biology

43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Charsar BA, Brinton MA, Locke K, Chen AY, Ghosh B, Urban MW, Komaravolu S, Krishnamurthy K, Smit R, Pasinelli P, Wright MC, Smith GM, Lepore AC. AAV2-BDNF promotes respiratory axon plasticity and recovery of diaphragm function following spinal cord injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901730R. PMID 31577916 DOI: 10.1096/fj.201901730R  0.36
2019 Urban MW, Ghosh B, Block CG, Strojny LR, Charsar BA, Goulão M, Komaravolu SS, Smith GM, Wright MC, Li S, Lepore AC. Long-distance axon regeneration promotes recovery of diaphragmatic respiratory function after spinal cord injury. Eneuro. PMID 31427403 DOI: 10.1523/ENEURO.0096-19.2019  0.36
2019 Urban MW, Ghosh B, Block CG, Charsar BA, Smith GM, Wright MC, Li S, Lepore AC. PTPσ inhibitory peptide promotes recovery of diaphragm function and sprouting of bulbospinal respiratory axons following cervical spinal cord injury. Journal of Neurotrauma. PMID 31392919 DOI: 10.1089/neu.2019.6586  0.36
2019 Ghosh B, Nong J, Wang Z, Urban MW, Heinsinger NM, Trovillion VA, Wright MC, Lepore AC, Zhong Y. A hydrogel engineered to deliver minocycline locally to the injured cervical spinal cord protects respiratory neural circuitry and preserves diaphragm function. Neurobiology of Disease. PMID 31028873 DOI: 10.1016/j.nbd.2019.04.014  0.36
2018 Goulão M, Ghosh B, Urban MW, Sahu M, Mercogliano C, Charsar BA, Komaravolu S, Block CG, Smith GM, Wright MC, Lepore AC. Astrocyte progenitor transplantation promotes regeneration of bulbospinal respiratory axons, recovery of diaphragm function, and a reduced macrophage response following cervical spinal cord injury. Glia. PMID 30548313 DOI: 10.1002/glia.23555  0.36
2018 Ghosh B, Wang Z, Nong J, Urban MW, Zhang Z, Trovillion VA, Wright MC, Zhong Y, Lepore AC. Local BDNF delivery to the injured cervical spinal cord using an engineered hydrogel enhances diaphragmatic respiratory function. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29891731 DOI: 10.1523/JNEUROSCI.3084-17.2018  0.36
2018 Muqeem T, Ghosh B, Pinto V, Lepore AC, Covarrubias M. Regulation of nociceptive glutamatergic signaling by presynaptic Kv3.4 channels in the rat spinal dorsal horn. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29540546 DOI: 10.1523/JNEUROSCI.3212-17.2018  0.36
2018 Falnikar A, Stratton J, Lin R, Andrews CE, Tyburski A, Trovillion VA, Gottschalk C, Ghosh B, Iacovitti L, Elliott MB, Lepore AC. Differential response in novel stem cell niches of the brain following cervical spinal cord injury and traumatic brain injury. Journal of Neurotrauma. PMID 29471717 DOI: 10.1089/neu.2017.5497  0.36
2018 Urban MW, Ghosh B, Strojny LR, Block CG, Blazejewski SM, Wright MC, Smith GM, Lepore AC. Cell-type specific expression of constitutively-active Rheb promotes regeneration of bulbospinal respiratory axons following cervical SCI. Experimental Neurology. PMID 29453976 DOI: 10.1016/j.expneurol.2018.02.007  0.36
2017 Zemel BM, Muqeem T, Brown EV, Goulão M, Urban MW, Tymanskyj SR, Lepore AC, Covarrubias M. Calcineurin dysregulation underlies spinal cord injury-induced K(+) channel dysfunction in DRG neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28751455 DOI: 10.1523/JNEUROSCI.0434-17.2017  0.36
2017 Rosenblum LT, Shamamandri-Markandaiah S, Ghosh B, Foran E, Lepore AC, Pasinelli P, Trotti D. Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS. Experimental Neurology. PMID 28342750 DOI: 10.1016/j.expneurol.2017.03.014  0.36
2016 Lane MA, Lepore AC, Fischer I. Improving the therapeutic efficacy of neural progenitor cell transplantation following spinal cord injury. Expert Review of Neurotherapeutics. PMID 27927055 DOI: 10.1080/14737175.2017.1270206  1
2016 Charsar BA, Urban MW, Lepore AC. Harnessing the power of cell transplantation to target respiratory dysfunction following spinal cord injury. Experimental Neurology. PMID 27531634 DOI: 10.1016/j.expneurol.2016.08.009  0.36
2015 Falnikar A, Hala TJ, Poulsen DJ, Lepore AC. GLT1 overexpression reverses established neuropathic pain-related behavior and attenuates chronic dorsal horn neuron activation following cervical spinal cord injury. Glia. PMID 26496514 DOI: 10.1002/glia.22936  0.56
2015 Li K, Javed E, Scura D, Hala TJ, Seetharam S, Falnikar A, Richard JP, Chorath A, Maragakis NJ, Wright MC, Lepore AC. Human iPS cell-derived astrocyte transplants preserve respiratory function after spinal cord injury. Experimental Neurology. PMID 26216662 DOI: 10.1016/j.expneurol.2015.07.020  0.56
2015 Martin M, Li K, Wright MC, Lepore AC. Functional and morphological assessment of diaphragm innervation by phrenic motor neurons. Journal of Visualized Experiments : Jove. e52605. PMID 26066371 DOI: 10.3791/52605  0.36
2015 Ritter DM, Zemel BM, Lepore AC, Covarrubias M. Kv3.4 channel function and dysfunction in nociceptors. Channels (Austin, Tex.). 9: 209-17. PMID 26039360 DOI: 10.1080/19336950.2015.1056949  0.56
2015 Li K, Hala TJ, Seetharam S, Poulsen DJ, Wright MC, Lepore AC. GLT1 overexpression in SOD1(G93A) mouse cervical spinal cord does not preserve diaphragm function or extend disease. Neurobiology of Disease. 78: 12-23. PMID 25818008 DOI: 10.1016/j.nbd.2015.03.010  0.56
2015 Ritter DM, Zemel BM, Hala TJ, O'Leary ME, Lepore AC, Covarrubias M. Dysregulation of Kv3.4 channels in dorsal root ganglia following spinal cord injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 1260-73. PMID 25609640 DOI: 10.1523/JNEUROSCI.1594-14.2015  0.56
2015 Li K, Javed E, Hala TJ, Sannie D, Regan KA, Maragakis NJ, Wright MC, Poulsen DJ, Lepore AC. Transplantation of glial progenitors that overexpress glutamate transporter GLT1 preserves diaphragm function following cervical SCI. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 533-48. PMID 25492561 DOI: 10.1038/mt.2014.236  0.56
2014 Watson JL, Hala TJ, Putatunda R, Sannie D, Lepore AC. Persistent at-level thermal hyperalgesia and tactile allodynia accompany chronic neuronal and astrocyte activation in superficial dorsal horn following mouse cervical contusion spinal cord injury. Plos One. 9: e109099. PMID 25268642 DOI: 10.1371/journal.pone.0109099  0.56
2014 Li K, Nicaise C, Sannie D, Hala TJ, Javed E, Parker JL, Putatunda R, Regan KA, Suain V, Brion JP, Rhoderick F, Wright MC, Poulsen DJ, Lepore AC. Overexpression of the astrocyte glutamate transporter GLT1 exacerbates phrenic motor neuron degeneration, diaphragm compromise, and forelimb motor dysfunction following cervical contusion spinal cord injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 7622-38. PMID 24872566 DOI: 10.1523/JNEUROSCI.4690-13.2014  0.56
2014 Putatunda R, Hala TJ, Chin J, Lepore AC. Chronic at-level thermal hyperalgesia following rat cervical contusion spinal cord injury is accompanied by neuronal and astrocyte activation and loss of the astrocyte glutamate transporter, GLT1, in superficial dorsal horn. Brain Research. 1581: 64-79. PMID 24833066 DOI: 10.1016/j.brainres.2014.05.003  0.56
2013 Nicaise C, Frank DM, Hala TJ, Authelet M, Pochet R, Adriaens D, Brion JP, Wright MC, Lepore AC. Early phrenic motor neuron loss and transient respiratory abnormalities after unilateral cervical spinal cord contusion. Journal of Neurotrauma. 30: 1092-9. PMID 23534670 DOI: 10.1089/neu.2012.2728  0.56
2012 Nicaise C, Putatunda R, Hala TJ, Regan KA, Frank DM, Brion JP, Leroy K, Pochet R, Wright MC, Lepore AC. Degeneration of phrenic motor neurons induces long-term diaphragm deficits following mid-cervical spinal contusion in mice. Journal of Neurotrauma. 29: 2748-60. PMID 23176637 DOI: 10.1089/neu.2012.2467  0.56
2012 Nicaise C, Hala TJ, Frank DM, Parker JL, Authelet M, Leroy K, Brion JP, Wright MC, Lepore AC. Phrenic motor neuron degeneration compromises phrenic axonal circuitry and diaphragm activity in a unilateral cervical contusion model of spinal cord injury. Experimental Neurology. 235: 539-52. PMID 22465264 DOI: 10.1016/j.expneurol.2012.03.007  0.56
2011 Lepore AC, O'Donnell J, Kim AS, Williams T, Tuteja A, Rao MS, Kelley LL, Campanelli JT, Maragakis NJ. Human glial-restricted progenitor transplantation into cervical spinal cord of the SOD1 mouse model of ALS. Plos One. 6: e25968. PMID 21998733 DOI: 10.1371/journal.pone.0025968  0.56
2011 Papadeas ST, Kraig SE, O'Banion C, Lepore AC, Maragakis NJ. Astrocytes carrying the superoxide dismutase 1 (SOD1G93A) mutation induce wild-type motor neuron degeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 108: 17803-8. PMID 21969586 DOI: 10.1073/pnas.1103141108  0.56
2011 Lepore AC, Maragakis NJ. Stem cell transplantation for spinal cord neurodegeneration. Methods in Molecular Biology (Clifton, N.J.). 793: 479-93. PMID 21913120 DOI: 10.1007/978-1-61779-328-8_31  0.56
2011 Lepore AC, O'Donnell J, Kim AS, Yang EJ, Tuteja A, Haidet-Phillips A, O'Banion CP, Maragakis NJ. Reduction in expression of the astrocyte glutamate transporter, GLT1, worsens functional and histological outcomes following traumatic spinal cord injury. Glia. 59: 1996-2005. PMID 21882244 DOI: 10.1002/glia.21241  0.56
2011 Lepore AC, O'Donnell J, Bonner JF, Paul C, Miller ME, Rauck B, Kushner RA, Rothstein JD, Fischer I, Maragakis NJ. Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury. Journal of Neuroscience Research. 89: 1001-17. PMID 21488085 DOI: 10.1002/jnr.22624  0.56
2010 Lepore AC, Tolmie C, O'Donnell J, Wright MC, Dejea C, Rauck B, Hoke A, Ignagni AR, Onders RP, Maragakis NJ. Peripheral hyperstimulation alters site of disease onset and course in SOD1 rats. Neurobiology of Disease. 39: 252-64. PMID 20381620 DOI: 10.1016/j.nbd.2010.03.021  0.56
2008 Lepore AC, Rauck B, Dejea C, Pardo AC, Rao MS, Rothstein JD, Maragakis NJ. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nature Neuroscience. 11: 1294-301. PMID 18931666 DOI: 10.1038/nn.2210  0.56
2008 Lepore AC, Dejea C, Carmen J, Rauck B, Kerr DA, Sofroniew MV, Maragakis NJ. Selective ablation of proliferating astrocytes does not affect disease outcome in either acute or chronic models of motor neuron degeneration. Experimental Neurology. 211: 423-32. PMID 18410928 DOI: 10.1016/j.expneurol.2008.02.020  0.56
2008 Magnus T, Carmen J, Deleon J, Xue H, Pardo AC, Lepore AC, Mattson MP, Rao MS, Maragakis NJ. Adult glial precursor proliferation in mutant SOD1G93A mice. Glia. 56: 200-8. PMID 18023016 DOI: 10.1002/glia.20604  0.56
2007 Lepore AC, Haenggeli C, Gasmi M, Bishop KM, Bartus RT, Maragakis NJ, Rothstein JD. Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS. Brain Research. 1185: 256-65. PMID 17963733 DOI: 10.1016/j.brainres.2007.09.034  0.56
2006 Lepore AC, Neuhuber B, Connors TM, Han SS, Liu Y, Daniels MP, Rao MS, Fischer I. Long-term fate of neural precursor cells following transplantation into developing and adult CNS. Neuroscience. 142: 287-304. PMID 17120358  1
2006 Lepore AC, Walczak P, Rao MS, Fischer I, Bulte JW. MR imaging of lineage-restricted neural precursors following transplantation into the adult spinal cord. Experimental Neurology. 201: 49-59. PMID 16764862 DOI: 10.1016/j.expneurol.2006.03.032  1
2006 Lepore AC, Neuhuber B, Connors TM, Han SS, Liu Y, Daniels MP, Rao MS, Fischer I. Long-term fate of neural precursor cells following transplantation into developing and adult CNS. Neuroscience. 139: 513-30. PMID 16458439 DOI: 10.1016/j.neuroscience.2005.12.043  1
2005 Mitsui T, Shumsky JS, Lepore AC, Murray M, Fischer I. Transplantation of neuronal and glial restricted precursors into contused spinal cord improves bladder and motor functions, decreases thermal hypersensitivity, and modifies intraspinal circuitry. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9624-36. PMID 16237167 DOI: 10.1523/JNEUROSCI.2175-05.2005  0.56
2005 Lepore AC, Bakshi A, Swanger SA, Rao MS, Fischer I. Neural precursor cells can be delivered into the injured cervical spinal cord by intrathecal injection at the lumbar cord. Brain Research. 1045: 206-16. PMID 15910779 DOI: 10.1016/j.brainres.2005.03.050  0.56
2005 Lepore AC, Fischer I. Lineage-restricted neural precursors survive, migrate, and differentiate following transplantation into the injured adult spinal cord. Experimental Neurology. 194: 230-42. PMID 15899260 DOI: 10.1016/j.expneurol.2005.02.020  1
2004 Lepore AC, Han SS, Tyler-Polsz CJ, Cai J, Rao MS, Fischer I. Differential fate of multipotent and lineage-restricted neural precursors following transplantation into the adult CNS. Neuron Glia Biology. 1: 113-26. PMID 16520830 DOI: 10.1017/s1740925x04000213  1
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