| Year |
Citation |
Score |
| 2024 |
Urban MW, Charsar BA, Heinsinger NM, Markandaiah SS, Sprimont L, Zhou W, Brown EV, Henderson NT, Thomas SJ, Ghosh B, Cain RE, Trotti D, Pasinelli P, Wright MC, Dalva MB, et al. EphrinB2 knockdown in cervical spinal cord preserves diaphragm innervation in a mutant SOD1 mouse model of ALS. Elife. 12. PMID 38224498 DOI: 10.7554/eLife.89298 |
0.456 |
|
| 2023 |
Urban MW, Charsar BA, Heinsinger NM, Markandaiah SS, Sprimont L, Zhou W, Henderson NT, Ghosh B, Cain RE, Trotti D, Pasinelli P, Wright MC, Dalva MB, Lepore AC. EphrinB2 knockdown in spinal cord astrocytes preserves diaphragm innervation in a mutant SOD1 mouse model of ALS. Biorxiv : the Preprint Server For Biology. PMID 37215009 DOI: 10.1101/2023.05.10.538887 |
0.459 |
|
| 2022 |
Jensen BK, McAvoy KJ, Heinsinger NM, Lepore AC, Ilieva H, Haeusler AR, Trotti D, Pasinelli P. Targeting TNFα produced by astrocytes expressing amyotrophic lateral sclerosis-linked mutant fused in sarcoma prevents neurodegeneration and motor dysfunction in mice. Glia. 70: 1426-1449. PMID 35474517 DOI: 10.1002/glia.24183 |
0.473 |
|
| 2022 |
Verdone BM, Cicardi ME, Wen X, Sriramoji S, Russell K, Markandaiah SS, Jensen BK, Krishnamurthy K, Haeusler AR, Pasinelli P, Trotti D. A mouse model with widespread expression of the C9orf72-linked glycine-arginine dipeptide displays non-lethal ALS/FTD-like phenotypes. Scientific Reports. 12: 5644. PMID 35379876 DOI: 10.1038/s41598-022-09593-z |
0.406 |
|
| 2020 |
Jensen BK, Schuldi MH, McAvoy K, Russell KA, Boehringer A, Curran BM, Krishnamurthy K, Wen X, Westergard T, Ma L, Haeusler AR, Edbauer D, Pasinelli P, Trotti D. Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment. Embo Molecular Medicine. 12: e10722. PMID 32347002 DOI: 10.15252/Emmm.201910722 |
0.485 |
|
| 2019 |
Casci I, Krishnamurthy K, Kour S, Tripathy V, Ramesh N, Anderson EN, Marrone L, Grant RA, Oliver S, Gochenaur L, Patel K, Sterneckert J, Gleixner AM, Donnelly CJ, Ruepp MD, ... ... Pasinelli P, et al. Muscleblind acts as a modifier of FUS toxicity by modulating stress granule dynamics and SMN localization. Nature Communications. 10: 5583. PMID 31811140 DOI: 10.1038/S41467-019-13383-Z |
0.472 |
|
| 2019 |
Charsar BA, Brinton MA, Locke K, Chen AY, Ghosh B, Urban MW, Komaravolu S, Krishnamurthy K, Smit R, Pasinelli P, Wright MC, Smith GM, Lepore AC. AAV2-BDNF promotes respiratory axon plasticity and recovery of diaphragm function following spinal cord injury. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. fj201901730R. PMID 31577916 DOI: 10.1096/Fj.201901730R |
0.319 |
|
| 2019 |
Mohamed LA, Markandaiah SS, Bonanno S, Pasinelli P, Trotti D. Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis. Experimental Neurology. PMID 30974102 DOI: 10.1016/J.Expneurol.2019.04.002 |
0.46 |
|
| 2019 |
Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, Pasinelli P, Trotti D, Haeusler A. Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. Embo Molecular Medicine. PMID 30617154 DOI: 10.15252/Emmm.201809423 |
0.466 |
|
| 2018 |
Kia A, McAvoy K, Krishnamurthy K, Trotti D, Pasinelli P. Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha. Glia. PMID 29380416 DOI: 10.1002/Glia.23298 |
0.494 |
|
| 2017 |
Mohamed LA, Markandaiah S, Bonanno S, Pasinelli P, Trotti D. Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies. The Aaps Journal. PMID 28779378 DOI: 10.1208/S12248-017-0120-6 |
0.386 |
|
| 2017 |
Rosenblum LT, Shamamandri-Markandaiah S, Ghosh B, Foran E, Lepore AC, Pasinelli P, Trotti D. Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS. Experimental Neurology. PMID 28342750 DOI: 10.1016/J.Expneurol.2017.03.014 |
0.512 |
|
| 2016 |
Westergard T, Jensen BK, Wen X, Cai J, Kropf E, Iacovitti L, Pasinelli P, Trotti D. Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD. Cell Reports. 17: 645-652. PMID 27732842 DOI: 10.1016/J.Celrep.2016.09.032 |
0.49 |
|
| 2016 |
Wen X, Westergard T, Pasinelli P, Trotti D. Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene. Neuroscience Letters. PMID 27619540 DOI: 10.1016/J.Neulet.2016.09.007 |
0.434 |
|
| 2016 |
Qosa H, Lichter J, Sarlo M, Markandaiah SS, McAvoy K, Richard JP, Jablonski MR, Maragakis NJ, Pasinelli P, Trotti D. Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis. Glia. PMID 27158936 DOI: 10.1002/Glia.23003 |
0.485 |
|
| 2016 |
Daigle JG, Krishnamurthy K, Ramesh N, Casci I, Monaghan J, McAvoy K, Godfrey EW, Daniel DC, Johnson EM, Monahan Z, Shewmaker F, Pasinelli P, Pandey UB. Pur-alpha regulates cytoplasmic stress granule dynamics and ameliorates FUS toxicity. Acta Neuropathologica. PMID 26728149 DOI: 10.1007/S00401-015-1530-0 |
0.409 |
|
| 2015 |
Qosa H, Miller DS, Pasinelli P, Trotti D. Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders. Brain Research. PMID 26187753 DOI: 10.1016/J.Brainres.2015.07.005 |
0.34 |
|
| 2015 |
Jablonski M, Miller DS, Pasinelli P, Trotti D. ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis. Brain Research. 1607: 1-14. PMID 25175835 DOI: 10.1016/J.Brainres.2014.08.060 |
0.502 |
|
| 2014 |
Jablonski MR, Markandaiah SS, Jacob D, Meng NJ, Li K, Gennaro V, Lepore AC, Trotti D, Pasinelli P. Inhibiting drug efflux transporters improves efficacy of ALS therapeutics. Annals of Clinical and Translational Neurology. 1: 996-1005. PMID 25574474 DOI: 10.1002/Acn3.141 |
0.449 |
|
| 2014 |
Wen X, Tan W, Westergard T, Krishnamurthy K, Markandaiah SS, Shi Y, Lin S, Shneider NA, Monaghan J, Pandey UB, Pasinelli P, Ichida JK, Trotti D. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death. Neuron. 84: 1213-25. PMID 25521377 DOI: 10.1016/J.Neuron.2014.12.010 |
0.507 |
|
| 2014 |
Foran E, Rosenblum L, Bogush A, Pasinelli P, Trotti D. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization. Glia. 62: 1241-53. PMID 24753081 DOI: 10.1002/Glia.22677 |
0.504 |
|
| 2014 |
Tan W, Pasinelli P, Trotti D. Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis. Biochimica Et Biophysica Acta. 1842: 1295-301. PMID 24568860 DOI: 10.1016/J.Bbadis.2014.02.009 |
0.462 |
|
| 2014 |
Shahidullah M, Fei H, LeMarchand S, Dalva M, Pasinelli P, Levitan IB. Defects in Synapse Structure and Function in a Fly Model of FUS-Related ALS Biophysical Journal. 106: 190a-191a. DOI: 10.1016/J.Bpj.2013.11.1113 |
0.504 |
|
| 2013 |
Shahidullah M, Le Marchand SJ, Fei H, Zhang J, Pandey UB, Dalva MB, Pasinelli P, Levitan IB. Defects in synapse structure and function precede motor neuron degeneration in Drosophila models of FUS-related ALS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 19590-8. PMID 24336723 DOI: 10.1523/Jneurosci.3396-13.2013 |
0.518 |
|
| 2013 |
Tan W, Naniche N, Bogush A, Pedrini S, Trotti D, Pasinelli P. Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11588-98. PMID 23843527 DOI: 10.1523/Jneurosci.5385-12.2013 |
0.415 |
|
| 2012 |
Jablonski MR, Jacob DA, Campos C, Miller DS, Maragakis NJ, Pasinelli P, Trotti D. Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS. Neurobiology of Disease. 47: 194-200. PMID 22521463 DOI: 10.1016/J.Nbd.2012.03.040 |
0.482 |
|
| 2012 |
Guareschi S, Cova E, Cereda C, Ceroni M, Donetti E, Bosco DA, Trotti D, Pasinelli P. An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1. Proceedings of the National Academy of Sciences of the United States of America. 109: 5074-9. PMID 22416121 DOI: 10.1073/Pnas.1115402109 |
0.468 |
|
| 2011 |
Naniche N, Sau D, Pasinelli P. In vivo and in vitro determination of cell death markers in neurons Methods in Molecular Biology. 793: 9-21. PMID 21913091 DOI: 10.1007/978-1-61779-328-8_2 |
0.349 |
|
| 2011 |
Foran E, Bogush A, Goffredo M, Roncaglia P, Gustincich S, Pasinelli P, Trotti D. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2. Glia. 59: 1719-31. PMID 21769946 DOI: 10.1002/Glia.21218 |
0.521 |
|
| 2010 |
Bosco DA, Morfini G, Karabacak NM, Song Y, Gros-Louis F, Pasinelli P, Goolsby H, Fontaine BA, Lemay N, McKenna-Yasek D, Frosch MP, Agar JN, Julien JP, Brady ST, Brown RH. Wild-type and mutant SOD1 share an aberrant conformation and a common pathogenic pathway in ALS. Nature Neuroscience. 13: 1396-403. PMID 20953194 DOI: 10.1038/Nn.2660 |
0.46 |
|
| 2010 |
Pedrini S, Sau D, Guareschi S, Bogush M, Brown RH, Naniche N, Kia A, Trotti D, Pasinelli P. ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2. Human Molecular Genetics. 19: 2974-86. PMID 20460269 DOI: 10.1093/Hmg/Ddq202 |
0.445 |
|
| 2008 |
Boston-Howes W, Williams EO, Bogush A, Scolere M, Pasinelli P, Trotti D. Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis. Experimental Neurology. 213: 229-37. PMID 18625223 DOI: 10.1016/J.Expneurol.2008.06.010 |
0.42 |
|
| 2007 |
Gibb SL, Boston-Howes W, Lavina ZS, Gustincich S, Brown RH, Pasinelli P, Trotti D. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 282: 32480-90. PMID 17823119 DOI: 10.1074/Jbc.M704314200 |
0.491 |
|
| 2007 |
Hetz C, Thielen P, Fisher J, Pasinelli P, Brown RH, Korsmeyer S, Glimcher L. The proapoptotic BCL-2 family member BIM mediates motoneuron loss in a model of amyotrophic lateral sclerosis Cell Death and Differentiation. 14: 1386-1389. PMID 17510659 DOI: 10.1038/Sj.Cdd.4402166 |
0.306 |
|
| 2006 |
Pasinelli P, Brown RH. Molecular biology of amyotrophic lateral sclerosis: Insights from genetics Nature Reviews Neuroscience. 7: 710-723. PMID 16924260 DOI: 10.1038/Nrn1971 |
0.49 |
|
| 2006 |
Boston-Howes W, Gibb SL, Williams EO, Pasinelli P, Brown RH, Trotti D. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. The Journal of Biological Chemistry. 281: 14076-84. PMID 16567804 DOI: 10.1074/Jbc.M600653200 |
0.512 |
|
| 2006 |
Broom WJ, Ay I, Pasinelli P, Brown RH. Inhibition of SOD1 expression by mitomycin C is a non-specific consequence of cellular toxicity Neuroscience Letters. 393: 184-188. PMID 16242241 DOI: 10.1016/J.Neulet.2005.09.064 |
0.518 |
|
| 2004 |
Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, Brown RH. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron. 43: 19-30. PMID 15233914 DOI: 10.1016/J.Neuron.2004.06.021 |
0.495 |
|
| 2004 |
Zhu S, Li M, Figueroa BE, Liu A, Stavrovskaya IG, Pasinelli P, Beal MF, Brown RH, Kristal BS, Ferrante RJ, Friedlander RM. Prophylactic creatine administration mediates neuroprotection in cerebral ischemia in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 5909-12. PMID 15229238 DOI: 10.1523/Jneurosci.1278-04.2004 |
0.339 |
|
| 2004 |
Maxwell MM, Pasinelli P, Kazantsev AG, Brown RH. RNA interference-mediated silencing of mutant superoxide dismutase rescues cyclosporin A-induced death in cultured neuroblastoma cells Proceedings of the National Academy of Sciences of the United States of America. 101: 3178-3183. PMID 14981234 DOI: 10.1073/Pnas.0308726100 |
0.504 |
|
| 2004 |
Dangond F, Hwang D, Camelo S, Pasinelli P, Frosch MP, Stephanopoulos G, Stephanopoulos G, Brown RH, Gullans SR. Molecular signature of late-stage human ALS revealed by expression profiling of postmortem spinal cord gray matter. Physiological Genomics. 16: 229-39. PMID 14645737 DOI: 10.1152/Physiolgenomics.00087.2001 |
0.449 |
|
| 2002 |
Cudkowicz ME, Pastusza KA, Sapp PC, Mathews RK, Leahy J, Pasinelli P, Francis JW, Jiang D, Andersen JK, Brown RH. Survival in transgenic ALS mice does not vary with CNS glutathione peroxidase activity Neurology. 59: 729-734. PMID 12221165 DOI: 10.1212/Wnl.59.5.729 |
0.457 |
|
| 2001 |
Nagai M, Aoki M, Miyoshi I, Kato M, Pasinelli P, Kasai N, Brown R.H. J, Itoyama Y. Rats expressing human cytosolic copper-zinc superoxide dismutase transgenes with amyotrophic lateral sclerosis: Associated mutations develop motor neuron disease Journal of Neuroscience. 21: 9246-9254. PMID 11717358 DOI: 10.1523/Jneurosci.21-23-09246.2001 |
0.524 |
|
| 2001 |
Trotti D, Aoki M, Pasinelli P, Berger UV, Danbolt NC, Brown RH, Hediger MA. Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity Journal of Biological Chemistry. 276: 576-582. PMID 11031254 DOI: 10.1074/Jbc.M003779200 |
0.359 |
|
| 2000 |
Pasinelli P, Houseweart MK, Brown RH, Cleveland DW. Caspase-1 and -3 are sequentially activated in motor neuron death in Cu,Zn superoxide dismutase-mediated familial amyotrophic lateral sclerosis. Proceedings of the National Academy of Sciences of the United States of America. 97: 13901-6. PMID 11095709 DOI: 10.1073/Pnas.240305897 |
0.424 |
|
| 1999 |
Lin KI, Pasinelli P, Brown RH, Hardwick JM, Ratan RR. Decreased intracellular superoxide levels activate Sindbis virus-induced apoptosis. The Journal of Biological Chemistry. 274: 13650-5. PMID 10224137 DOI: 10.1074/Jbc.274.19.13650 |
0.335 |
|
| 1998 |
Pasinelli P, Borchelt DR, Houseweart MK, Cleveland DW, Brown RH. Caspase-1 is activated in neural cells and tissue with amyotrophic lateral sclerosis-associated mutations in copper-zinc superoxide dismutase. Proceedings of the National Academy of Sciences of the United States of America. 95: 15763-8. PMID 9861044 DOI: 10.1073/Pnas.95.26.15763 |
0.509 |
|
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