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Toshinori Hoshi - Publications

Affiliations: 
University of Pennsylvania, Philadelphia, PA, United States 
Area:
Ion channels, Oxidative regulation
Website:
http://www.med.upenn.edu/ins/faculty/hoshi.htm
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155 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Gessner G, Jamili M, Tomczyk P, Menche D, Schönherr R, Hoshi T, Heinemann SH. Extracellular hemin is a reverse use-dependent gating modifier of cardiac voltage-gated Na channels. Biological Chemistry. PMID 36038266 DOI: 10.1515/hsz-2022-0194  0.665
2022 Sahoo N, Yang K, Coburger I, Bernert A, Swain SM, Gessner G, Kappl R, Kühl T, Imhof D, Hoshi T, Schönherr R, Heinemann SH. Intracellular hemin is a potent inhibitor of the voltage-gated potassium channel Kv10.1. Scientific Reports. 12: 14645. PMID 36030326 DOI: 10.1038/s41598-022-18975-2  0.688
2022 Kuldyushev N, Schönherr R, Coburger I, Ahmed M, Hussein RA, Wiesel E, Godbole A, Pfirrmann T, Hoshi T, Heinemann SH. A GFP-based ratiometric sensor for cellular methionine oxidation. Talanta. 243: 123332. PMID 35276500 DOI: 10.1016/j.talanta.2022.123332  0.473
2021 Rühl P, Langner JM, Reidel J, Schönherr R, Hoshi T, Heinemann SH. Monitoring of compound resting membrane potentials of cell cultures with ratiometric genetically encoded voltage indicators. Communications Biology. 4: 1164. PMID 34620975 DOI: 10.1038/s42003-021-02675-0  0.537
2021 Lu Y, Zhang W, Zhang B, Heinemann SH, Hoshi T, Hou S, Zhang G. Bilirubin Oxidation End Products (BOXes) Induce Neuronal Oxidative Stress Involving the Nrf2 Pathway. Oxidative Medicine and Cellular Longevity. 2021: 8869908. PMID 34373769 DOI: 10.1155/2021/8869908  0.473
2020 Gessner G, Rühl P, Westerhausen M, Hoshi T, Heinemann SH. Fe-Mediated Activation of BK Channels by Rapid Photolysis of CORM-S1 Releasing CO and Fe. Acs Chemical Biology. PMID 32667185 DOI: 10.1021/acschembio.0c00282  0.593
2020 Coburger I, Yang K, Bernert A, Wiesel E, Sahoo N, Swain SM, Hoshi T, Schönherr R, Heinemann SH. Impact of intracellular hemin on N-type inactivation of voltage-gated K channels. Pflugers Archiv : European Journal of Physiology. PMID 32388729 DOI: 10.1007/S00424-020-02386-1  0.7
2019 Tian Y, Heinemann SH, Hoshi T. Large-conductance Ca- and voltage-gated K channels form and break interactions with membrane lipids during each gating cycle. Proceedings of the National Academy of Sciences of the United States of America. PMID 30967508 DOI: 10.1073/pnas.1901381116  0.69
2019 Sahoo N, Coburger I, Yang K, Swain SM, Gessner G, Kappl R, Imhof D, Hoshi T, Schoenherr R, Heinemann SH. Modulation of KV10.1 Potassium Channel Function by Intracellular Heme Biophysical Journal. 116: 15a. DOI: 10.1016/J.Bpj.2018.11.124  0.705
2018 Yang K, Coburger I, Langner JM, Peter N, Hoshi T, Schönherr R, Heinemann SH. Modulation of K channel N-type inactivation by sulfhydration through hydrogen sulfide and polysulfides. Pflugers Archiv : European Journal of Physiology. PMID 30415410 DOI: 10.1007/s00424-018-2233-x  0.684
2017 Gessner G, Sahoo N, Swain SM, Hirth G, Schönherr R, Mede R, Westerhausen M, Brewitz HH, Heimer P, Imhof D, Hoshi T, Heinemann SH. CO-independent modification of K(+) channels by tricarbonyldichlororuthenium(II) dimer (CORM-2). European Journal of Pharmacology. PMID 28987271 DOI: 10.1016/J.Ejphar.2017.10.006  0.679
2017 Ojha NK, Leipold E, Schönherr R, Hoshi T, Heinemann SH. Non-photonic sensing of membrane-delimited reactive species with a Na(+) channel protein containing selenocysteine. Scientific Reports. 7: 46003. PMID 28378799 DOI: 10.1038/srep46003  0.606
2017 Yusifov T, Savalli N, Pantazis A, Heinemann SH, Hoshi T, Olcese R. Carbon Monoxide May Regulate BK slo1 Channel Activity by Partially Disrupting Heme Coordination Biophysical Journal. 112: 112a. DOI: 10.1016/J.Bpj.2016.11.631  0.655
2016 Tian Y, Aursnes M, Hansen TV, Tungen JE, Galpin JD, Leisle L, Ahern CA, Xu R, Heinemann SH, Hoshi T. Atomic determinants of BK channel activation by polyunsaturated fatty acids. Proceedings of the National Academy of Sciences of the United States of America. PMID 27849612 DOI: 10.1073/Pnas.1615562113  0.65
2016 Hoshi T, Heinemann SH. Modulation of BK Channels by Small Endogenous Molecules and Pharmaceutical Channel Openers. International Review of Neurobiology. 128: 193-237. PMID 27238265 DOI: 10.1016/bs.irn.2016.03.020  0.704
2016 Han B, He K, Cai C, Tang Y, Yang L, Heinemann SH, Hoshi T, Hou S. Human EAG channels are directly modulated by PIP2 as revealed by electrophysiological and optical interference investigations. Scientific Reports. 6: 23417. PMID 27005320 DOI: 10.1038/srep23417  0.697
2016 Gessner G, Hoshi T, Heinemann SH. Functional Impact of P320 in hSlo1 BK Channel Gating Biophysical Journal. 110: 280a. DOI: 10.1016/J.BPJ.2015.11.1516  0.686
2015 Hoshi T, Armstrong CM. The Cole-Moore Effect: Still Unexplained? Biophysical Journal. 109: 1312-6. PMID 26445430 DOI: 10.1016/j.bpj.2015.07.052  0.329
2015 Schink M, Leipold E, Schirmeyer J, Schönherr R, Hoshi T, Heinemann SH. Reactive species modify NaV1.8 channels and affect action potentials in murine dorsal root ganglion neurons. Pflugers Archiv : European Journal of Physiology. PMID 26383867 DOI: 10.1007/s00424-015-1735-z  0.585
2015 Tian Y, Ullrich F, Xu R, Heinemann SH, Hou S, Hoshi T. Two distinct effects of PIP2 underlie auxiliary subunit-dependent modulation of Slo1 BK channels. The Journal of General Physiology. 145: 331-43. PMID 25825171 DOI: 10.1085/jgp.201511363  0.794
2015 Yusifov T, Savalli N, Heinemann SH, Hoshi T, Olcese R. The Heme-Bound Human BK Channel Gating Ring is a Co Sensor Biophysical Journal. 108: 122a. DOI: 10.1016/J.Bpj.2014.11.682  0.695
2015 Tian Y, Ullrich F, Xu R, Stefan HH, Hou S, Hoshi T. Differential Effects of PIP2 on Slo1 BK Channels with Different Auxiliary Subunits Biophysical Journal. 108: 436a. DOI: 10.1016/j.bpj.2014.11.2382  0.487
2014 Armstrong CM, Hoshi T. K⁺ channel gating: C-type inactivation is enhanced by calcium or lanthanum outside. The Journal of General Physiology. 144: 221-30. PMID 25156116 DOI: 10.1085/jgp.201411223  0.528
2014 Strauss KA, Markx S, Georgi B, Paul SM, Jinks RN, Hoshi T, McDonald A, First MB, Liu W, Benkert AR, Heaps AD, Tian Y, Chakravarti A, Bucan M, Puffenberger EG. A population-based study of KCNH7 p.Arg394His and bipolar spectrum disorder. Human Molecular Genetics. 23: 6395-406. PMID 24986916 DOI: 10.1093/Hmg/Ddu335  0.332
2014 Mancini M, Soldovieri MV, Gessner G, Wissuwa B, Barrese V, Boscia F, Secondo A, Miceli F, Franco C, Ambrosino P, Canzoniero LM, Bauer M, Hoshi T, Heinemann SH, Taglialatela M. Critical role of large-conductance calcium- and voltage-activated potassium channels in leptin-induced neuroprotection of N-methyl-d-aspartate-exposed cortical neurons. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 87: 80-6. PMID 24973659 DOI: 10.1016/j.phrs.2014.06.010  0.644
2014 Heinemann SH, Hoshi T, Westerhausen M, Schiller A. Carbon monoxide--physiology, detection and controlled release. Chemical Communications (Cambridge, England). 50: 3644-60. PMID 24556640 DOI: 10.1039/c3cc49196j  0.536
2014 Ojha NK, Nematian-Ardestani E, Neugebauer S, Borowski B, El-Hussein A, Hoshi T, Leipold E, Heinemann SH. Sodium channels as gateable non-photonic sensors for membrane-delimited reactive species. Biochimica Et Biophysica Acta. 1838: 1412-9. PMID 24513256 DOI: 10.1016/j.bbamem.2014.01.031  0.616
2014 Sahoo N, Hoshi T, Heinemann SH. Oxidative modulation of voltage-gated potassium channels. Antioxidants & Redox Signaling. 21: 933-52. PMID 24040918 DOI: 10.1089/ars.2013.5614  0.715
2014 Hoshi T, Xu R, Hou S, Heinemann SH, Tian Y. A Point Mutation that Impairs the Omega-3 Fatty Acid Sensitivity of Human Slo1 BK Channels Biophysical Journal. 106: 749a. DOI: 10.1016/j.bpj.2013.11.4125  0.67
2014 Gessner G, Held K, Hoshi T, Heinemann SH. Whole-Cell Gating-Charge Measurements for Analysis of Allosteric Domain Coupling in Hslo1 BK Channels Biophysical Journal. 106: 744a. DOI: 10.1016/j.bpj.2013.11.4096  0.693
2014 Armstrong CM, Hoshi T. Enhancement of C-Type Inactivation by External Ca2+ and La3+ Biophysical Journal. 106: 537a. DOI: 10.1016/j.bpj.2013.11.2995  0.366
2014 Hoshi T. Auxilary-Subunitdependent Modulation of SLO1 BK Channels that Underlies the Hypotensive Effectof Fish Oil Biophysical Journal. 106: 8a-9a. DOI: 10.1016/j.bpj.2013.11.094  0.428
2013 Hoshi T, Xu R, Hou S, Heinemann SH, Tian Y. A point mutation in the human Slo1 channel that impairs its sensitivity to omega-3 docosahexaenoic acid. The Journal of General Physiology. 142: 507-22. PMID 24127525 DOI: 10.1085/jgp.201311061  0.711
2013 Sahoo N, Goradia N, Ohlenschläger O, Schönherr R, Friedrich M, Plass W, Kappl R, Hoshi T, Heinemann SH. Heme impairs the ball-and-chain inactivation of potassium channels. Proceedings of the National Academy of Sciences of the United States of America. 110: E4036-44. PMID 24082096 DOI: 10.1073/pnas.1313247110  0.706
2013 Hoshi T, Wissuwa B, Tian Y, Tajima N, Xu R, Bauer M, Heinemann SH, Hou S. Reply to Harris et al.: Differential impacts of omega-3 fatty acids and their derivatives on blood pressure. Proceedings of the National Academy of Sciences of the United States of America. 110: E2260. PMID 23940844 DOI: 10.1073/pnas.1305790110  0.572
2013 Hoshi T, Pantazis A, Olcese R. Transduction of voltage and Ca2+ signals by Slo1 BK channels. Physiology (Bethesda, Md.). 28: 172-89. PMID 23636263 DOI: 10.1152/Physiol.00055.2012  0.533
2013 Hoshi T, Tian Y, Xu R, Heinemann SH, Hou S. Mechanism of the modulation of BK potassium channel complexes with different auxiliary subunit compositions by the omega-3 fatty acid DHA. Proceedings of the National Academy of Sciences of the United States of America. 110: 4822-7. PMID 23487786 DOI: 10.1073/pnas.1222003110  0.709
2013 Hoshi T, Wissuwa B, Tian Y, Tajima N, Xu R, Bauer M, Heinemann SH, Hou S. Omega-3 fatty acids lower blood pressure by directly activating large-conductance Ca²⁺-dependent K⁺ channels. Proceedings of the National Academy of Sciences of the United States of America. 110: 4816-21. PMID 23487785 DOI: 10.1073/pnas.1221997110  0.681
2013 Hoshi T, Armstrong CM. C-type inactivation of voltage-gated K+ channels: pore constriction or dilation? The Journal of General Physiology. 141: 151-60. PMID 23319730 DOI: 10.1085/jgp.201210888  0.567
2013 Gessner G, Hoshi T, Heinemann SH. Modulation of Hslo1 BK Channels by Aminoglycoside Antibiotics Biophysical Journal. 104: 473a. DOI: 10.1016/j.bpj.2012.11.2611  0.736
2013 Tian Y, Ullrich F, Xu R, Heinemann SH, Hou S, Hoshi T. Differential Effects of PIP2 on Slo1 BK Channels with Different β Subunits Biophysical Journal. 104: 472a. DOI: 10.1016/j.bpj.2012.11.2609  0.669
2013 Hoshi T, Wissuwa B, Tian Y, Tajima N, Xu R, Bauer M, Heinemann SH, Hou S. Omega-3 Fatty Acids Activate Slo1 BK Channels and Lower Blood Pressure Biophysical Journal. 104: 471a. DOI: 10.1016/j.bpj.2012.11.2604  0.684
2012 Hoshi T, Armstrong CM. Initial steps in the opening of a Shaker potassium channel. Proceedings of the National Academy of Sciences of the United States of America. 109: 12800-4. PMID 22802655 DOI: 10.1073/pnas.1209665109  0.533
2012 Gessner G, Cui YM, Otani Y, Ohwada T, Soom M, Hoshi T, Heinemann SH. Molecular mechanism of pharmacological activation of BK channels. Proceedings of the National Academy of Sciences of the United States of America. 109: 3552-7. PMID 22331907 DOI: 10.1073/pnas.1114321109  0.743
2012 Sahoo N, Schönherr R, Hoshi T, Heinemann SH. Cysteines control the N- and C-linker-dependent gating of KCNH1 potassium channels. Biochimica Et Biophysica Acta. 1818: 1187-95. PMID 22310694 DOI: 10.1016/j.bbamem.2012.01.021  0.713
2012 Yusifov T, Javaherian AD, Heinemann SH, Hoshi T, Olcese R. Evidence for Lipid-Induced Structural Rearrangements in the Human BK (Slo1) Channel Gating Ring Biophysical Journal. 102: 688a. DOI: 10.1016/J.Bpj.2011.11.3738  0.667
2012 Yusifov T, Javaherian AD, Heinemann SH, Hoshi T, Olcese R. Calcium and Heme Induce Distinct Conformational States of the Human BK (Slo1) Channel Gating Ring Biophysical Journal. 102: 687a-688a. DOI: 10.1016/J.Bpj.2011.11.3737  0.585
2012 Armstrong CM, Hoshi T. Initial Opening Steps of K+ Channels Probed by Extracellular Multivalent Cations Biophysical Journal. 102: 529a. DOI: 10.1016/j.bpj.2011.11.2893  0.436
2011 Dean T, Xu R, Joiner W, Sehgal A, Hoshi T. Drosophila QVR/SSS modulates the activation and C-type inactivation kinetics of Shaker K(+) channels. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 11387-95. PMID 21813698 DOI: 10.1523/Jneurosci.0502-11.2011  0.659
2011 Cox DH, Hoshi T. Where's the gate? Gating in the deep pore of the BK(Ca) channel. The Journal of General Physiology. 138: 133-6. PMID 21746844 DOI: 10.1085/jgp.201110681  0.717
2011 Hou S, Xu R, Clark JF, Wurster WL, Heinemann SH, Hoshi T. Bilirubin oxidation end products directly alter K+ channels important in the regulation of vascular tone. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 102-12. PMID 20424637 DOI: 10.1038/jcbfm.2010.54  0.737
2011 Gessner G, Hoshi T, Heinemann SH. Influence of Hydrophobic Residues on BK Channel Gating Biophysical Journal. 100: 582a. DOI: 10.1016/j.bpj.2010.12.3363  0.704
2010 Kolbe K, Schönherr R, Gessner G, Sahoo N, Hoshi T, Heinemann SH. Cysteine 723 in the C-linker segment confers oxidative inhibition of hERG1 potassium channels. The Journal of Physiology. 588: 2999-3009. PMID 20547678 DOI: 10.1113/jphysiol.2010.192468  0.725
2010 Hou S, Vigeland LE, Zhang G, Xu R, Li M, Heinemann SH, Hoshi T. Zn2+ activates large conductance Ca2+-activated K+ channel via an intracellular domain. The Journal of Biological Chemistry. 285: 6434-42. PMID 20037152 DOI: 10.1074/jbc.M109.069211  0.71
2010 Wu MN, Joiner WJ, Dean T, Yue Z, Smith CJ, Chen D, Hoshi T, Sehgal A, Koh K. SLEEPLESS, a Ly-6/neurotoxin family member, regulates the levels, localization and activity of Shaker. Nature Neuroscience. 13: 69-75. PMID 20010822 DOI: 10.1038/Nn.2454  0.561
2010 Yusifov T, Javaherian A, Gandhi C, Hou S, Heinemann S, Hoshi T, Olcese R. Heme-Driven Conformational Changes in the Human Slo1 BKCa Channel Gating Ring Biophysical Journal. 98: 126a. DOI: 10.1016/J.Bpj.2009.12.684  0.645
2010 Hoshi T, Im W, Armstrong CM. Pore Dilation in C-Type Inactivation of Potassium Channels Biophysical Journal. 98: 522a. DOI: 10.1016/J.Bpj.2009.12.2836  0.443
2010 Gessner G, Cui Y, Otani Y, Ohwada T, Hoshi T, Heinemann SH. Molecular Determinants For hSlo1 Bk Channel Activation by Dihydroabietic Acid Derivatives Biophysical Journal. 98: 316a. DOI: 10.1016/j.bpj.2009.12.1717  0.719
2010 Hou S, Vigeland LE, Zhang G, Xu R, Li M, Heinemann SH, Hoshi T. Zn2+ Activates Human Large-Conductance Ca2+-Activated K+ Channel Biophysical Journal. 98: 316a. DOI: 10.1016/j.bpj.2009.12.1716  0.714
2009 Hou S, Horrigan FT, Xu R, Heinemann SH, Hoshi T. Comparative effects of H+ and Ca2+ on large-conductance Ca2+- and voltage-gated Slo1 K+ channels. Channels (Austin, Tex.). 3: 249-58. PMID 19617704 DOI: 10.4161/chan.3.4.9253  0.825
2009 Hou S, Heinemann SH, Hoshi T. Modulation of BKCa channel gating by endogenous signaling molecules. Physiology (Bethesda, Md.). 24: 26-35. PMID 19196649 DOI: 10.1152/physiol.00032.2008  0.704
2009 Horrigan FT, Hoshi T. Erratum: Corrigendum: Integration of an electric-metal sensory experience in the Slo1 BK channel Nature Structural & Molecular Biology. 16: 572-572. DOI: 10.1038/nsmb0509-572b  0.737
2009 Hou S, Horrigan FT, Heinemann SH, Hoshi T. Comparative Mechanisms Of Activation Of The Slo1 BK Channel By Ca2+ And H+ Mediated By The RCK1 Domain Biophysical Journal. 96: 473a-474a. DOI: 10.1016/j.bpj.2008.12.2451  0.806
2009 Hou S, Horrigan FT, Xu R, Heinemann SH, Hoshi T. Comparative effects of H+ and Ca2+ on large-conductance Ca2+-and voltage-gated slo1 K+ channels Channels. 3.  0.794
2008 Haenold R, Wassef R, Brot N, Neugebauer S, Leipold E, Heinemann SH, Hoshi T. Protection of vascular smooth muscle cells by over-expressed methionine sulphoxide reductase A: role of intracellular localization and substrate availability. Free Radical Research. 42: 978-88. PMID 19085252 DOI: 10.1080/10715760802566541  0.542
2008 Horrigan FT, Hoshi T. Integration of an electric-metal sensory experience in the Slo1 BK channel. Nature Structural & Molecular Biology. 15: 1130-2. PMID 18985066 DOI: 10.1038/nsmb1108-1130  0.777
2008 Soom M, Gessner G, Heuer H, Hoshi T, Heinemann SH. A mutually exclusive alternative exon of slo1 codes for a neuronal BK channel with altered function. Channels (Austin, Tex.). 2: 278-82. PMID 18719396 DOI: 10.4161/chan.2.4.6571  0.697
2008 Nakata M, Baba H, Kanai K, Hoshi T, Sawai S, Hattori T, Kuwabara S. Changes in Na(+) channel expression and nodal persistent Na(+) currents associated with peripheral nerve regeneration in mice. Muscle & Nerve. 37: 721-30. PMID 18506710 DOI: 10.1002/mus.21031  0.324
2008 Kassmann M, Hansel A, Leipold E, Birkenbeil J, Lu SQ, Hoshi T, Heinemann SH. Oxidation of multiple methionine residues impairs rapid sodium channel inactivation. Pflã¼Gers Archiv : European Journal of Physiology. 456: 1085-95. PMID 18369661 DOI: 10.1007/s00424-008-0477-6  0.674
2008 Hou S, Xu R, Heinemann SH, Hoshi T. Reciprocal regulation of the Ca2+ and H+ sensitivity in the SLO1 BK channel conferred by the RCK1 domain. Nature Structural & Molecular Biology. 15: 403-10. PMID 18345016 DOI: 10.1038/nsmb.1398  0.695
2008 Hou S, Xu R, Heinemann SH, Hoshi T. The RCK1 high-affinity Ca2+ sensor confers carbon monoxide sensitivity to Slo1 BK channels. Proceedings of the National Academy of Sciences of the United States of America. 105: 4039-43. PMID 18316727 DOI: 10.1073/pnas.0800304105  0.725
2007 Wassef R, Haenold R, Hansel A, Brot N, Heinemann SH, Hoshi T. Methionine sulfoxide reductase A and a dietary supplement S-methyl-L-cysteine prevent Parkinson's-like symptoms. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 12808-16. PMID 18032652 DOI: 10.1523/JNEUROSCI.0322-07.2007  0.518
2007 Haenold R, Wassef R, Hansel A, Heinemann SH, Hoshi T. Identification of a new functional splice variant of the enzyme methionine sulphoxide reductase A (MSRA) expressed in rat vascular smooth muscle cells. Free Radical Research. 41: 1233-45. PMID 17907003 DOI: 10.1080/10715760701642096  0.525
2007 Su Z, Limberis J, Martin RL, Xu R, Kolbe K, Heinemann SH, Hoshi T, Cox BF, Gintant GA. Functional consequences of methionine oxidation of hERG potassium channels. Biochemical Pharmacology. 74: 702-11. PMID 17624316 DOI: 10.1016/j.bcp.2007.06.002  0.727
2007 Ma D, Nakata T, Zhang G, Hoshi T, Li M, Shikano S. Differential trafficking of carboxyl isoforms of Ca2+-gated (Slo1) potassium channels. Febs Letters. 581: 1000-8. PMID 17303127 DOI: 10.1016/j.febslet.2007.01.077  0.541
2007 Gessner G, Heller R, Hoshi T, Heinemann SH. The amiodarone derivative 2-methyl-3-(3,5-diiodo-4-carboxymethoxybenzyl)benzofuran (KB130015) opens large-conductance Ca2+-activated K+ channels and relaxes vascular smooth muscle. European Journal of Pharmacology. 555: 185-93. PMID 17134694 DOI: 10.1016/j.ejphar.2006.10.053  0.681
2006 Hou S, Reynolds MF, Horrigan FT, Heinemann SH, Hoshi T. Reversible binding of heme to proteins in cellular signal transduction. Accounts of Chemical Research. 39: 918-24. PMID 17176030 DOI: 10.1021/ar040020w  0.765
2006 Heinemann SH, Hoshi T. Multifunctional potassium channels: electrical switches and redox enzymes, all in one. Science's Stke : Signal Transduction Knowledge Environment. 2006: pe33. PMID 16940439 DOI: 10.1126/stke.3502006pe33  0.702
2006 Zhang G, Xu R, Heinemann SH, Hoshi T. Cysteine oxidation and rundown of large-conductance Ca2+-dependent K+ channels. Biochemical and Biophysical Research Communications. 342: 1389-95. PMID 16516848 DOI: 10.1016/j.bbrc.2006.02.079  0.731
2006 Santarelli LC, Wassef R, Heinemann SH, Hoshi T. Three methionine residues located within the regulator of conductance for K+ (RCK) domains confer oxidative sensitivity to large-conductance Ca2+-activated K+ channels. The Journal of Physiology. 571: 329-48. PMID 16396928 DOI: 10.1113/jphysiol.2005.101089  0.808
2006 Lahiri S, Roy A, Baby SM, Hoshi T, Semenza GL, Prabhakar NR. Oxygen sensing in the body. Progress in Biophysics and Molecular Biology. 91: 249-86. PMID 16137743 DOI: 10.1016/J.Pbiomolbio.2005.07.001  0.317
2005 Haenold R, Wassef DM, Heinemann SH, Hoshi T. Oxidative damage, aging and anti-aging strategies. Age (Dordrecht, Netherlands). 27: 183-99. PMID 23598652 DOI: 10.1007/s11357-005-2915-0  0.517
2005 Gessner G, Schönherr K, Soom M, Hansel A, Asim M, Baniahmad A, Derst C, Hoshi T, Heinemann SH. BKCa channels activating at resting potential without calcium in LNCaP prostate cancer cells. The Journal of Membrane Biology. 208: 229-40. PMID 16604468 DOI: 10.1007/s00232-005-0830-z  0.687
2005 Horrigan FT, Heinemann SH, Hoshi T. Heme regulates allosteric activation of the Slo1 BK channel. The Journal of General Physiology. 126: 7-21. PMID 15955873 DOI: 10.1085/jgp.200509262  0.842
2005 Hansel A, Heinemann SH, Hoshi T. Heterogeneity and function of mammalian MSRs: enzymes for repair, protection and regulation. Biochimica Et Biophysica Acta. 1703: 239-47. PMID 15680232 DOI: 10.1016/j.bbapap.2004.09.010  0.59
2004 Hoshi T, Lahiri S. Cell biology. Oxygen sensing: it's a gas! Science (New York, N.Y.). 306: 2050-1. PMID 15604396 DOI: 10.1126/science.1107069  0.312
2004 Santarelli LC, Chen J, Heinemann SH, Hoshi T. The beta1 subunit enhances oxidative regulation of large-conductance calcium-activated K+ channels. The Journal of General Physiology. 124: 357-70. PMID 15452197 DOI: 10.1085/jgp.200409144  0.816
2004 Tang XD, Santarelli LC, Heinemann SH, Hoshi T. Metabolic regulation of potassium channels. Annual Review of Physiology. 66: 131-59. PMID 14977399 DOI: 10.1146/annurev.physiol.66.041002.142720  0.811
2004 Tang XD, Garcia ML, Heinemann SH, Hoshi T. Reactive oxygen species impair Slo1 BK channel function by altering cysteine-mediated calcium sensing. Nature Structural & Molecular Biology. 11: 171-8. PMID 14745441 DOI: 10.1038/nsmb725  0.65
2004 Yermolaieva O, Xu R, Schinstock C, Brot N, Weissbach H, Heinemann SH, Hoshi T. Methionine sulfoxide reductase A protects neuronal cells against brief hypoxia/reoxygenation. Proceedings of the National Academy of Sciences of the United States of America. 101: 1159-64. PMID 14745014 DOI: 10.1073/Pnas.0308215100  0.525
2003 Hansel A, Jung S, Hoshi T, Heinemann SH. A second human methionine sulfoxide reductase (hMSRB2) reducing methionine-R-sulfoxide displays a tissue expression pattern distinct from hMSRB1. Redox Report : Communications in Free Radical Research. 8: 384-8. PMID 14980072 DOI: 10.1179/135100003225003429  0.514
2003 Tang XD, Xu R, Reynolds MF, Garcia ML, Heinemann SH, Hoshi T. Haem can bind to and inhibit mammalian calcium-dependent Slo1 BK channels. Nature. 425: 531-5. PMID 14523450 DOI: 10.1038/nature02003  0.728
2003 Avdonin V, Tang XD, Hoshi T. Stimulatory action of internal protons on Slo1 BK channels. Biophysical Journal. 84: 2969-80. PMID 12719228 DOI: 10.1016/S0006-3495(03)70023-X  0.506
2002 Jung S, Hansel A, Kasperczyk H, Hoshi T, Heinemann SH. Activity, tissue distribution and site-directed mutagenesis of a human peptide methionine sulfoxide reductase of type B: hCBS1. Febs Letters. 527: 91-4. PMID 12220640 DOI: 10.1016/S0014-5793(02)03171-X  0.565
2002 Padanilam BJ, Lu T, Hoshi T, Padanilam BA, Shibata EF, Lee HC. Molecular determinants of intracellular pH modulation of human Kv1.4 N-type inactivation. Molecular Pharmacology. 62: 127-34. PMID 12065763 DOI: 10.1124/Mol.62.1.127  0.357
2002 Hansel A, Kuschel L, Hehl S, Lemke C, Agricola HJ, Hoshi T, Heinemann SH. Mitochondrial targeting of the human peptide methionine sulfoxide reductase (MSRA), an enzyme involved in the repair of oxidized proteins. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 16: 911-3. PMID 12039877 DOI: 10.1096/fj.01-0737fje  0.522
2002 Wemmie JA, Chen J, Askwith CC, Hruska-Hageman AM, Price MP, Nolan BC, Yoder PG, Lamani E, Hoshi T, Freeman JH, Welsh MJ. The acid-activated ion channel ASIC contributes to synaptic plasticity, learning, and memory. Neuron. 34: 463-77. PMID 11988176 DOI: 10.1016/S0896-6273(02)00661-X  0.363
2002 Geib S, Sandoz G, Mabrouk K, Matavel A, Marchot P, Hoshi T, Villaz M, Ronjat M, Miquelis R, Lévêque C, de Waard M. Use of a purified and functional recombinant calcium-channel beta4 subunit in surface-plasmon resonance studies. The Biochemical Journal. 364: 285-92. PMID 11988102 DOI: 10.1042/Bj3640285  0.475
2002 Chen J, Daggett H, De Waard M, Heinemann SH, Hoshi T. Nitric oxide augments voltage-gated P/Q-type Ca(2+) channels constituting a putative positive feedback loop. Free Radical Biology & Medicine. 32: 638-49. PMID 11909698 DOI: 10.1016/S0891-5849(02)00748-7  0.635
2002 Ruan H, Tang XD, Chen ML, Joiner ML, Sun G, Brot N, Weissbach H, Heinemann SH, Iverson L, Wu CF, Hoshi T, Chen ML, Joiner MA, Heinemann SH. High-quality life extension by the enzyme peptide methionine sulfoxide reductase. Proceedings of the National Academy of Sciences of the United States of America. 99: 2748-53. PMID 11867705 DOI: 10.1073/pnas.032671199  0.528
2002 Weissbach H, Etienne F, Hoshi T, Heinemann SH, Lowther WT, Matthews B, St John G, Nathan C, Brot N. Peptide methionine sulfoxide reductase: structure, mechanism of action, and biological function. Archives of Biochemistry and Biophysics. 397: 172-8. PMID 11795868 DOI: 10.1006/Abbi.2001.2664  0.534
2002 Geib S, Sandoz G, Cornet V, Mabrouk K, Fund-Saunier O, Bichet D, Villaz M, Hoshi T, Sabatier JM, De Waard M. The interaction between the I-II loop and the III-IV loop of Cav2.1 contributes to voltage-dependent inactivation in a beta -dependent manner. The Journal of Biological Chemistry. 277: 10003-13. PMID 11790766 DOI: 10.1074/Jbc.M106231200  0.342
2001 Lu T, Hoshi T, Weintraub NL, Spector AA, Lee HC. Activation of ATP-sensitive K(+) channels by epoxyeicosatrienoic acids in rat cardiac ventricular myocytes. The Journal of Physiology. 537: 811-27. PMID 11744757 DOI: 10.1111/J.1469-7793.2001.00811.X  0.505
2001 Yermolaieva O, Chen J, Couceyro PR, Hoshi T. Cocaine- and amphetamine-regulated transcript peptide modulation of voltage-gated Ca2+ signaling in hippocampal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 7474-80. PMID 11567037 DOI: 10.1523/Jneurosci.21-19-07474.2001  0.362
2001 Avdonin V, Hoshi T. Modification of voltage-dependent gating of potassium channels by free form of tryptophan side chain. Biophysical Journal. 81: 97-106. PMID 11423398 DOI: 10.1016/S0006-3495(01)75683-4  0.598
2001 Hennager DJ, Ikuma M, Hoshi T, Welsh MJ. A conditional probability analysis of cystic fibrosis transmembrane conductance regulator gating indicates that ATP has multiple effects during the gating cycle. Proceedings of the National Academy of Sciences of the United States of America. 98: 3594-9. PMID 11248123 DOI: 10.1073/Pnas.051633298  0.469
2001 Tang XD, Daggett H, Hanner M, Garcia ML, McManus OB, Brot N, Weissbach H, Heinemann SH, Hoshi T. Oxidative regulation of large conductance calcium-activated potassium channels. The Journal of General Physiology. 117: 253-74. PMID 11222629 DOI: 10.1085/Jgp.117.3.253  0.721
2001 Hoshi T, Heinemann S. Regulation of cell function by methionine oxidation and reduction. The Journal of Physiology. 531: 1-11. PMID 11179387 DOI: 10.1111/j.1469-7793.2001.0001j.x  0.585
2000 Chen ML, Hoshi T, Wu CF. Sh and eag K(+) channel subunit interaction in frog oocytes depends on level and time of expression. Biophysical Journal. 79: 1358-68. PMID 10968998 DOI: 10.1016/S0006-3495(00)76388-0  0.491
2000 Avdonin V, Nolan B, Sabatier JM, De Waard M, Hoshi T. Mechanisms of maurotoxin action on Shaker potassium channels. Biophysical Journal. 79: 776-87. PMID 10920011 DOI: 10.1016/S0006-3495(00)76335-1  0.597
2000 Carlier E, Avdonin V, Geib S, Fajloun Z, Kharrat R, Rochat H, Sabatier JM, Hoshi T, De Waard M. Effect of maurotoxin, a four disulfide-bridged toxin from the chactoid scorpion Scorpio maurus, on Shaker K+ channels. The Journal of Peptide Research : Official Journal of the American Peptide Society. 55: 419-27. PMID 10888198 DOI: 10.1034/j.1399-3011.2000.00715.x  0.601
2000 Tang XD, Marten I, Dietrich P, Ivashikina N, Hedrich R, Hoshi T. Histidine(118) in the S2-S3 linker specifically controls activation of the KAT1 channel expressed in Xenopus oocytes. Biophysical Journal. 78: 1255-69. PMID 10692314 DOI: 10.1016/S0006-3495(00)76682-3  0.494
2000 Chen J, Avdonin V, Ciorba MA, Heinemann SH, Hoshi T. Acceleration of P/C-type inactivation in voltage-gated K(+) channels by methionine oxidation. Biophysical Journal. 78: 174-87. PMID 10620284 DOI: 10.1016/S0006-3495(00)76583-0  0.694
2000 Yermolaieva O, Brot N, Weissbach H, Heinemann SH, Hoshi T. Reactive oxygen species and nitric oxide mediate plasticity of neuronal calcium signaling. Proceedings of the National Academy of Sciences of the United States of America. 97: 448-53. PMID 10618438 DOI: 10.1073/Pnas.97.1.448  0.543
1999 Kuschel L, Hansel A, Schönherr R, Weissbach H, Brot N, Hoshi T, Heinemann SH. Molecular cloning and functional expression of a human peptide methionine sulfoxide reductase (hMsrA). Febs Letters. 456: 17-21. PMID 10452521 DOI: 10.1016/S0014-5793(99)00917-5  0.595
1999 Zei PC, Ogielska EM, Hoshi T, Aldrich RW. Effects on ion permeation with hydrophobic substitutions at a residue in Shaker S6 that interacts with a signature sequence amino acid. Annals of the New York Academy of Sciences. 868: 458-64. PMID 10414322 DOI: 10.1111/j.1749-6632.1999.tb11314.x  0.76
1999 Marten I, Hoth S, Deeken R, Ache P, Ketchum KA, Hoshi T, Hedrich R. AKT3, a phloem-localized K+ channel, is blocked by protons. Proceedings of the National Academy of Sciences of the United States of America. 96: 7581-6. PMID 10377458 DOI: 10.1073/pnas.96.13.7581  0.562
1999 Tang XD, Hoshi T. Rundown of the hyperpolarization-activated KAT1 channel involves slowing of the opening transitions regulated by phosphorylation. Biophysical Journal. 76: 3089-98. PMID 10354434 DOI: 10.1016/S0006-3495(99)77461-8  0.599
1999 Ciorba MA, Heinemann SH, Weissbach H, Brot N, Hoshi T. Regulation of voltage-dependent K+ channels by methionine oxidation: effect of nitric oxide and vitamin C. Febs Letters. 442: 48-52. PMID 9923602 DOI: 10.1016/S0014-5793(98)01616-0  0.693
1998 Avdonin V, Kasuya J, Ciorba MA, Kaplan B, Hoshi T, Iverson L. Apoptotic proteins Reaper and Grim induce stable inactivation in voltage-gated K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 95: 11703-8. PMID 9751729 DOI: 10.1073/pnas.95.20.11703  0.574
1998 Li A, Ségui J, Heinemann SH, Hoshi T. Oxidation regulates cloned neuronal voltage-dependent Ca2+ channels expressed in Xenopus oocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 6740-7. PMID 9712645 DOI: 10.1523/Jneurosci.18-17-06740.1998  0.709
1998 Avdonin V, Hoshi T. Kinetic models and simulation: practical approaches and implementation notes. Methods in Enzymology. 293: 724-59. PMID 9711634 DOI: 10.1016/S0076-6879(98)93039-7  0.495
1998 Marten I, Hoshi T. The N-terminus of the K channel KAT1 controls its voltage-dependent gating by altering the membrane electric field. Biophysical Journal. 74: 2953-62. PMID 9635749 DOI: 10.1016/S0006-3495(98)78002-6  0.564
1998 Chen H, Kubo Y, Hoshi T, Heinemann SH. Cyclosporin A selectively reduces the functional expression of Kir2.1 potassium channels in Xenopus oocytes. Febs Letters. 422: 307-10. PMID 9498805 DOI: 10.1016/S0014-5793(98)00028-3  0.685
1997 Ciorba MA, Heinemann SH, Weissbach H, Brot N, Hoshi T. Modulation of potassium channel function by methionine oxidation and reduction. Proceedings of the National Academy of Sciences of the United States of America. 94: 9932-7. PMID 9275229 DOI: 10.1073/Pnas.94.18.9932  0.62
1997 Dreyer I, Antunes S, Hoshi T, Müller-Röber B, Palme K, Pongs O, Reintanz B, Hedrich R. Plant K+ channel α-subunits assemble indiscriminately Biophysical Journal. 72: 2143-2150. PMID 9129816 DOI: 10.1016/S0006-3495(97)78857-X  0.515
1997 Marten I, Hoshi T. Voltage-dependent gating characteristics of the K+ channel KAT1 depend on the N and C termini Proceedings of the National Academy of Sciences of the United States of America. 94: 3448-3453. PMID 9096414 DOI: 10.1073/pnas.94.7.3448  0.51
1997 Avdonin V, Shibata EF, Hoshi T. Dihydropyridine action on voltage-dependent potassium channels expressed in Xenopus oocytes Journal of General Physiology. 109: 169-180. PMID 9041446 DOI: 10.1085/Jgp.109.2.169  0.62
1996 Chen ML, Hoshi T, Wu CF. Heteromultimeric interactions among K+ channel subunits from Shaker and eag families in Xenopus oocytes Neuron. 17: 535-542. PMID 8816716 DOI: 10.1016/S0896-6273(00)80185-3  0.502
1995 Ogielska EM, Zagotta WN, Hoshi T, Heinemann SH, Haab J, Aldrich RW. Cooperative subunit interactions in C-type inactivation of K channels. Biophysical Journal. 69: 2449-57. PMID 8599651 DOI: 10.1016/S0006-3495(95)80114-1  0.83
1995 Hoshi T. Regulation of voltage dependence of the KAT1 channel by intracellular factors Journal of General Physiology. 105: 309-328. PMID 7769379 DOI: 10.1085/jgp.105.3.309  0.617
1995 Welsh MJ, Hoshi T. Molecular cardiology. Ion channels lose the rhythm. Nature. 376: 640. PMID 7651510 DOI: 10.1038/376640A0  0.473
1994 Zagotta WN, Hoshi T, Aldrich RW. Shaker potassium channel gating. III: Evaluation of kinetic models for activation. The Journal of General Physiology. 103: 321-62. PMID 8189208 DOI: 10.1085/Jgp.103.2.321  0.801
1994 Zagotta WN, Hoshi T, Dittman J, Aldrich RW. Shaker potassium channel gating. II: Transitions in the activation pathway. The Journal of General Physiology. 103: 279-319. PMID 8189207 DOI: 10.1085/Jgp.103.2.279  0.75
1994 Hoshi T, Zagotta WN, Aldrich RW. Shaker potassium channel gating. I: Transitions near the open state. The Journal of General Physiology. 103: 249-78. PMID 8189206 DOI: 10.1085/Jgp.103.2.249  0.787
1994 Hoshi T. Mechanism of voltage-dependent gating in potassium channels Neuroscience Research Supplements. 19: S10. DOI: 10.1016/0921-8696(94)92294-2  0.49
1993 Hoshi T, Zagotta WN. Recent advances in the understanding of potassium channel function. Current Opinion in Neurobiology. 3: 283-90. PMID 8369623 DOI: 10.1016/0959-4388(93)90119-J  0.727
1993 López-Barneo J, Hoshi T, Heinemann SH, Aldrich RW. Effects of external cations and mutations in the pore region on C-type inactivation of Shaker potassium channels. Receptors & Channels. 1: 61-71. PMID 8081712  0.748
1991 Hoshi T, Zagotta WN, Aldrich RW. Two types of inactivation in Shaker K+ channels: effects of alterations in the carboxy-terminal region. Neuron. 7: 547-56. PMID 1931050 DOI: 10.1016/0896-6273(91)90367-9  0.781
1991 Zagotta WN, Hoshi T, Aldrich RW. Erratum: Restoration of Inactivation in Mutants Of Shaker Potassium Channels by a Peptide Derived from ShB Science. 252: 1049-1049. DOI: 10.1126/science.252.5009.1049-b  0.759
1990 Garber SS, Hoshi T, Aldrich RW. Interaction of forskolin with voltage-gated K+ channels in PC12 cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 3361-8. PMID 2213145 DOI: 10.1523/Jneurosci.10-10-03361.1990  0.745
1990 Aldrich RW, Hoshi T, Zagotta WN. Differences in gating among amino-terminal variants of Shaker potassium channels. Cold Spring Harbor Symposia On Quantitative Biology. 55: 19-27. PMID 2132814 DOI: 10.1101/Sqb.1990.055.01.005  0.805
1990 Zagotta WN, Hoshi T, Aldrich RW. Restoration of inactivation in mutants of Shaker potassium channels by a peptide derived from ShB. Science (New York, N.Y.). 250: 568-71. PMID 2122520 DOI: 10.1126/Science.2122520  0.775
1990 Hoshi T, Zagotta WN, Aldrich RW. Biophysical and molecular mechanisms of Shaker potassium channel inactivation. Science (New York, N.Y.). 250: 533-8. PMID 2122519 DOI: 10.1126/Science.2122519  0.815
1989 Zagotta WN, Hoshi T, Aldrich RW. Gating of single Shaker potassium channels in Drosophila muscle and in Xenopus oocytes injected with Shaker mRNA. Proceedings of the National Academy of Sciences of the United States of America. 86: 7243-7. PMID 2506548 DOI: 10.1073/Pnas.86.18.7243  0.809
1989 Zagotta WN, Germeraad S, Garber SS, Hoshi T, Aldrich RW. Properties of ShB A-type potassium channels expressed in Shaker mutant Drosophila by germline transformation. Neuron. 3: 773-82. PMID 2484347 DOI: 10.1016/0896-6273(89)90246-8  0.75
1989 Garber SS, Hoshi T, Aldrich RW. Regulation of ionic currents in pheochromocytoma cells by nerve growth factor and dexamethasone. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 3976-87. PMID 2479727 DOI: 10.1523/Jneurosci.09-11-03976.1989  0.594
1988 Hoshi T, Garber SS, Aldrich RW. Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation. Science (New York, N.Y.). 240: 1652-5. PMID 2454506 DOI: 10.1126/Science.2454506  0.73
1988 Hoshi T, Aldrich RW. Voltage-dependent K+ currents and underlying single K+ channels in pheochromocytoma cells. The Journal of General Physiology. 91: 73-106. PMID 2449514 DOI: 10.1085/Jgp.91.1.73  0.723
1988 Hoshi T, Aldrich RW. Gating kinetics of four classes of voltage-dependent K+ channels in pheochromocytoma cells. The Journal of General Physiology. 91: 107-31. PMID 2449512 DOI: 10.1085/Jgp.91.1.107  0.747
1987 Matsunaga H, Maruyama Y, Kojima I, Hoshi T. Transient Ca2+-channel current characterized by a low-threshold voltage in zona glomerulosa cells of rat adrenal cortex. Pflugers Archiv : European Journal of Physiology. 408: 351-5. PMID 2438640 DOI: 10.1007/BF00581128  0.321
1987 Hoshi T, Smith SJ. Large depolarization induces long openings of voltage-dependent calcium channels in adrenal chromaffin cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 7: 571-80. PMID 2434631 DOI: 10.1523/Jneurosci.07-02-00571.1987  0.537
1987 Hoshi T, Smith S. Large depolarization induces long openings of voltage-dependent calcium channels in adrenal chromaffin cells The Journal of Neuroscience. 7: 571-580. DOI: 10.1523/JNEUROSCI.07-02-00571.1987  0.585
1986 Maruyama Y, Matsunaga H, Hoshi T. Ca2+- and voltage activated K+ channel in apical cell membrane of gallbladder epithelium from Triturus. Pflugers Archiv : European Journal of Physiology. 406: 563-7. PMID 2423961 DOI: 10.1007/BF00584021  0.445
1984 Hoshi T, Rothlein J, Smith SJ. Facilitation of Ca2+-channel currents in bovine adrenal chromaffin cells. Proceedings of the National Academy of Sciences of the United States of America. 81: 5871-5. PMID 6091117 DOI: 10.1073/PNAS.81.18.5871  0.633
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