Ronald A. Bush - Publications

National Eye Institute, Bethesda, Maryland 
visual system, retina, genetics, retinal degeneration, gene therapy

42 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bush RA, Tanikawa A, Zeng Y, Sieving PA. Cone ERG Changes During Light Adaptation in Two All-Cone Mutant Mice: Implications for Rod-Cone Pathway Interactions. Investigative Ophthalmology & Visual Science. 60: 3680-3688. PMID 31469895 DOI: 10.1167/iovs.19-27242  0.52
2019 Zeng Y, Qian H, Wu Z, Marangoni D, Sieving PA, Bush RA. AAVrh-10 transduces outer retinal cells in rodents and rabbits following intravitreal administration. Gene Therapy. PMID 31308478 DOI: 10.1038/s41434-019-0094-3  0.52
2019 Song H, Bush RA, Zeng Y, Qian H, Wu Z, Sieving PA. Trans-ocular Electric Current Enhances AAV-Mediated Retinal Gene Transduction after Intravitreal Vector Administration. Molecular Therapy. Methods & Clinical Development. 13: 77-85. PMID 30719486 DOI: 10.1016/j.omtm.2018.12.006  0.52
2018 Cukras C, Wiley HE, Jeffrey BG, Sen HN, Turriff A, Zeng Y, Vijayasarathy C, Marangoni D, Ziccardi L, Kjellstrom S, Park TK, Hiriyanna S, Wright JF, Colosi P, Wu Z, ... Bush RA, et al. Retinal AAV8-RS1 Gene Therapy for X-Linked Retinoschisis: Initial Findings from a Phase I/IIa Trial by Intravitreal Delivery. Molecular Therapy : the Journal of the American Society of Gene Therapy. 26: 2282-2294. PMID 30196853 DOI: 10.1016/j.ymthe.2018.05.025  0.52
2017 Marangoni D, Yong Z, Kjellström S, Vijayasarathy C, A Sieving P, Bush RA. Rearing Light Intensity Affects Inner Retinal Pathology in a Mouse Model of X-Linked Retinoschisis but Does Not Alter Gene Therapy Outcome. Investigative Ophthalmology & Visual Science. 58: 1656-1664. PMID 28297725 DOI: 10.1167/iovs.16-21016  0.4
2016 Marangoni D, Bush RA, Zeng Y, Wei LL, Ziccardi L, Vijayasarathy C, Bartoe JT, Palyada K, Santos M, Hiriyanna S, Wu Z, Colosi P, Sieving PA. Ocular and systemic safety of a recombinant AAV8 vector for X-linked retinoschisis gene therapy: GLP studies in rabbits and Rs1-KO mice. Molecular Therapy. Methods & Clinical Development. 5: 16011. PMID 27626041 DOI: 10.1038/mtm.2016.11  0.52
2016 Zeng Y, Petralia RS, Vijayasarathy C, Wu Z, Hiriyanna S, Song H, Wang YX, Sieving PA, Bush RA. Retinal Structure and Gene Therapy Outcome in Retinoschisin-Deficient Mice Assessed by Spectral-Domain Optical Coherence Tomography. Investigative Ophthalmology & Visual Science. 57: OCT277-OCT287. PMID 27409484 DOI: 10.1167/iovs.15-18920  0.52
2016 Song H, Vijayasarathy C, Zeng Y, Marangoni D, Bush RA, Wu Z, Sieving PA. NADPH Oxidase Contributes to Photoreceptor Degeneration in Constitutively Active RAC1 Mice. Investigative Ophthalmology & Visual Science. 57: 2864-2875. PMID 27233035 DOI: 10.1167/iovs.15-18974  0.52
2016 Bush RA, Zeng Y, Colosi P, Kjellstrom S, Hiriyanna S, Vijayasarathy C, Santos M, Li J, Wu Z, Sieving PA. Preclinical Dose Escalation Study of Intravitreal AAV-RS1 Gene Therapy in a Mouse Model of X-linked Retinoschisis: Dose-Dependent Expression and Improved Retinal Structure and Function. Human Gene Therapy. PMID 27036983 DOI: 10.1089/hum.2015.142  0.52
2015 Marangoni D, Vijayasarathy C, Bush RA, Wei LL, Wen R, Sieving PA. Intravitreal Ciliary Neurotrophic Factor Transiently Improves Cone-Mediated Function in a CNGB3-/- Mouse Model of Achromatopsia. Investigative Ophthalmology & Visual Science. 56: 6810-6822. PMID 26567794 DOI: 10.1167/iovs.15-16866  0.52
2015 Bush RA, Wei LL, Sieving PA. Convergence of Human Genetics and Animal Studies: Gene Therapy for X-Linked Retinoschisis. Cold Spring Harbor Perspectives in Medicine. PMID 26101206 DOI: 10.1101/cshperspect.a017368  0.52
2015 Ou J, Vijayasarathy C, Ziccardi L, Chen S, Zeng Y, Marangoni D, Pope JG, Bush RA, Wu Z, Li W, Sieving PA. Synaptic pathology and therapeutic repair in adult retinoschisis mouse by AAV-RS1 transfer. The Journal of Clinical Investigation. PMID 26098217 DOI: 10.1172/JCI81380  0.52
2014 Marangoni D, Wu Z, Wiley HE, Zeiss CJ, Vijayasarathy C, Zeng Y, Hiriyanna S, Bush RA, Wei LL, Colosi P, Sieving PA. Preclinical safety evaluation of a recombinant AAV8 vector for X-linked retinoschisis after intravitreal administration in rabbits. Human Gene Therapy. Clinical Development. 25: 202-11. PMID 25211193 DOI: 10.1089/humc.2014.067  0.52
2014 Zein WM, Jeffrey BG, Wiley HE, Turriff AE, Tumminia SJ, Tao W, Bush RA, Marangoni D, Wen R, Wei LL, Sieving PA. CNGB3-achromatopsia clinical trial with CNTF: diminished rod pathway responses with no evidence of improvement in cone function. Investigative Ophthalmology & Visual Science. 55: 6301-8. PMID 25205868 DOI: 10.1167/iovs.14-14860  0.52
2014 Ziccardi L, Vijayasarathy C, Bush RA, Sieving PA. Photoreceptor pathology in the X-linked retinoschisis (XLRS) mouse results in delayed rod maturation and impaired light driven transducin translocation. Advances in Experimental Medicine and Biology. 801: 559-66. PMID 24664744 DOI: 10.1007/978-1-4614-3209-8_71  0.52
2014 Song H, Bush RA, Vijayasarathy C, Fariss RN, Kjellstrom S, Sieving PA. Transgenic expression of constitutively active RAC1 disrupts mouse rod morphogenesis. Investigative Ophthalmology & Visual Science. 55: 2659-68. PMID 24651551 DOI: 10.1167/iovs.13-13649  0.52
2012 Ziccardi L, Vijayasarathy C, Bush RA, Sieving PA. Loss of retinoschisin (RS1) cell surface protein in maturing mouse rod photoreceptors elevates the luminance threshold for light-driven translocation of transducin but not arrestin. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13010-21. PMID 22993419 DOI: 10.1523/JNEUROSCI.1913-12.2012  0.52
2011 Bowles K, Cukras C, Turriff A, Sergeev Y, Vitale S, Bush RA, Sieving PA. X-linked retinoschisis: RS1 mutation severity and age affect the ERG phenotype in a cohort of 68 affected male subjects. Investigative Ophthalmology & Visual Science. 52: 9250-6. PMID 22039241 DOI: 10.1167/iovs.11-8115  0.52
2010 Raz-Prag D, Grimes WN, Fariss RN, Vijayasarathy C, Campos MM, Bush RA, Diamond JS, Sieving PA. Probing potassium channel function in vivo by intracellular delivery of antibodies in a rat model of retinal neurodegeneration. Proceedings of the National Academy of Sciences of the United States of America. 107: 12710-5. PMID 20616020 DOI: 10.1073/pnas.0913472107  0.52
2009 Haruta M, Bush RA, Kjellstrom S, Vijayasarathy C, Zeng Y, Le YZ, Sieving PA. Depleting Rac1 in mouse rod photoreceptors protects them from photo-oxidative stress without affecting their structure or function Proceedings of the National Academy of Sciences of the United States of America. 106: 9397-9402. PMID 19470639 DOI: 10.1073/pnas.0808940106  0.52
2009 Park TK, Wu Z, Kjellstrom S, Zeng Y, Bush RA, Sieving PA, Colosi P. Intravitreal delivery of AAV8 retinoschisin results in cell type-specific gene expression and retinal rescue in the Rs1-KO mouse. Gene Therapy. 16: 916-26. PMID 19458650 DOI: 10.1038/gt.2009.61  0.52
2009 Raz-Prag D, Zeng Y, Sieving PA, Bush RA. Photoreceptor protection by adeno-associated virus-mediated LEDGF expression in the RCS rat model of retinal degeneration: probing the mechanism. Investigative Ophthalmology & Visual Science. 50: 3897-906. PMID 19324854 DOI: 10.1167/iovs.08-3153  0.52
2008 Ahmed ZM, Kjellstrom S, Haywood-Watson RJ, Bush RA, Hampton LL, Battey JF, Riazuddin S, Frolenkov G, Sieving PA, Friedman TB. Double homozygous waltzer and Ames waltzer mice provide no evidence of retinal degeneration. Molecular Vision. 14: 2227-36. PMID 19057657  0.52
2008 Takada Y, Vijayasarathy C, Zeng Y, Kjellstrom S, Bush RA, Sieving PA. Synaptic pathology in retinoschisis knockout (Rs1-/y) mouse retina and modification by rAAV-Rs1 gene delivery. Investigative Ophthalmology & Visual Science. 49: 3677-86. PMID 18660429 DOI: 10.1167/iovs.07-1071  0.52
2008 Vijayasarathy C, Takada Y, Zeng Y, Bush RA, Sieving PA. Organization and molecular interactions of retinoschisin in photoreceptors. Advances in Experimental Medicine and Biology. 613: 291-7. PMID 18188957 DOI: 10.1007/978-0-387-74904-4_34  0.52
2008 Machida S, Raz-Prag D, Fariss RN, Sieving PA, Bush RA. Photopic ERG negative response from amacrine cell signaling in RCS rat retinal degeneration. Investigative Ophthalmology & Visual Science. 49: 442-52. PMID 18172124 DOI: 10.1167/iovs.07-0291  0.52
2007 Woodruff ML, Olshevskaya EV, Savchenko AB, Peshenko IV, Barrett R, Bush RA, Sieving PA, Fain GL, Dizhoor AM. Constitutive excitation by Gly90Asp rhodopsin rescues rods from degeneration caused by elevated production of cGMP in the dark. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 8805-15. PMID 17699662 DOI: 10.1523/JNEUROSCI.2751-07.2007  0.52
2007 Kjellstrom S, Bush RA, Zeng Y, Takada Y, Sieving PA. Retinoschisin gene therapy and natural history in the Rs1h-KO mouse: long-term rescue from retinal degeneration. Investigative Ophthalmology & Visual Science. 48: 3837-45. PMID 17652759 DOI: 10.1167/iovs.07-0203  0.52
2007 Vijayasarathy C, Takada Y, Zeng Y, Bush RA, Sieving PA. Retinoschisin is a peripheral membrane protein with affinity for anionic phospholipids and affected by divalent cations. Investigative Ophthalmology & Visual Science. 48: 991-1000. PMID 17325137 DOI: 10.1167/iovs.06-0915  0.52
2006 Wen R, Song Y, Kjellstrom S, Tanikawa A, Liu Y, Li Y, Zhao L, Bush RA, Laties AM, Sieving PA. Regulation of rod phototransduction machinery by ciliary neurotrophic factor. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 13523-30. PMID 17192435 DOI: 10.1523/JNEUROSCI.4021-06.2006  0.52
2006 Takada Y, Fariss RN, Muller M, Bush RA, Rushing EJ, Sieving PA. Retinoschisin expression and localization in rodent and human pineal and consequences of mouse RS1 gene knockout. Molecular Vision. 12: 1108-16. PMID 17093404  0.52
2006 Aslanukov A, Bhowmick R, Guruju M, Oswald J, Raz D, Bush RA, Sieving PA, Lu X, Bock CB, Ferreira PA. RanBP2 modulates Cox11 and hexokinase I activities and haploinsufficiency of RanBP2 causes deficits in glucose metabolism. Plos Genetics. 2: e177. PMID 17069463 DOI: 10.1371/journal.pgen.0020177  0.52
2006 Vasireddy V, Jablonski MM, Mandal MN, Raz-Prag D, Wang XF, Nizol L, Iannaccone A, Musch DC, Bush RA, Salem N, Sieving PA, Ayyagari R. Elovl4 5-bp-deletion knock-in mice develop progressive photoreceptor degeneration. Investigative Ophthalmology & Visual Science. 47: 4558-68. PMID 17003453 DOI: 10.1167/iovs.06-0353  0.52
2006 Vijayasarathy C, Gawinowicz MA, Zeng Y, Takada Y, Bush RA, Sieving PA. Identification and characterization of two mature isoforms of retinoschisin in murine retina. Biochemical and Biophysical Research Communications. 349: 99-105. PMID 16930543 DOI: 10.1016/j.bbrc.2006.07.202  0.52
2006 Raz-Prag D, Ayyagari R, Fariss RN, Mandal MN, Vasireddy V, Majchrzak S, Webber AL, Bush RA, Salem N, Petrukhin K, Sieving PA. Haploinsufficiency is not the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease. Investigative Ophthalmology & Visual Science. 47: 3603-11. PMID 16877435 DOI: 10.1167/iovs.05-1527  0.52
2006 Haywood-Watson RJ, Ahmed ZM, Kjellstrom S, Bush RA, Takada Y, Hampton LL, Battey JF, Sieving PA, Friedman TB. Ames Waltzer deaf mice have reduced electroretinogram amplitudes and complex alternative splicing of Pcdh15 transcripts. Investigative Ophthalmology & Visual Science. 47: 3074-84. PMID 16799054 DOI: 10.1167/iovs.06-0108  0.52
2006 Sieving PA, Caruso RC, Tao W, Coleman HR, Thompson DJ, Fullmer KR, Bush RA. Ciliary neurotrophic factor (CNTF) for human retinal degeneration: phase I trial of CNTF delivered by encapsulated cell intraocular implants. Proceedings of the National Academy of Sciences of the United States of America. 103: 3896-901. PMID 16505355 DOI: 10.1073/pnas.0600236103  0.52
2005 Brzezinski JA, Brown NL, Tanikawa A, Bush RA, Sieving PA, Vitaterna MH, Takahashi JS, Glaser T. Loss of circadian photoentrainment and abnormal retinal electrophysiology in Math5 mutant mice. Investigative Ophthalmology & Visual Science. 46: 2540-51. PMID 15980246 DOI: 10.1167/iovs.04-1123  0.52
2005 Khan NW, Kondo M, Hiriyanna KT, Jamison JA, Bush RA, Sieving PA. Primate Retinal Signaling Pathways: Suppressing ON-Pathway Activity in Monkey With Glutamate Analogues Mimics Human CSNB1-NYX Genetic Night Blindness. Journal of Neurophysiology. 93: 481-92. PMID 15331616 DOI: 10.1152/jn.00365.2004  0.52
2004 Zeng Y, Takada Y, Kjellstrom S, Hiriyanna K, Tanikawa A, Wawrousek E, Smaoui N, Caruso R, Bush RA, Sieving PA. RS-1 Gene Delivery to an Adult Rs1h Knockout Mouse Model Restores ERG b-Wave with Reversal of the Electronegative Waveform of X-Linked Retinoschisis. Investigative Ophthalmology & Visual Science. 45: 3279-85. PMID 15326152 DOI: 10.1167/iovs.04-0576  0.52
2004 Bush RA, Lei B, Tao W, Raz D, Chan CC, Cox TA, Santos-Muffley M, Sieving PA. Encapsulated cell-based intraocular delivery of ciliary neurotrophic factor in normal rabbit: dose-dependent effects on ERG and retinal histology. Investigative Ophthalmology & Visual Science. 45: 2420-30. PMID 15223826 DOI: 10.1167/iovs.03-1342  0.52
2002 Traverso V, Bush RA, Sieving PA, Deretic D. Retinal cAMP levels during the progression of retinal degeneration in rhodopsin P23H and S334ter transgenic rats. Investigative Ophthalmology & Visual Science. 43: 1655-61. PMID 11980887  0.52
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