Robert J. Vandenberg - Publications

University of Sydney, Camperdown, New South Wales, Australia 

83 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Wilson KA, Mostyn SN, Frangos ZJ, Shimmon S, Rawling T, Vandenberg RJ, O'Mara ML. The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavity. The Journal of Biological Chemistry. 100282. PMID 33450225 DOI: 10.1016/j.jbc.2021.100282  0.76
2020 Sheipouri D, Gallagher CI, Shimmon S, Rawling T, Vandenberg RJ. A System for Assessing Dual Action Modulators of Glycine Transporters and Glycine Receptors. Biomolecules. 10. PMID 33266066 DOI: 10.3390/biom10121618  0.76
2020 Aubrey KR, Sheipouri D, Balle T, Vandenberg RJ, Otsu Y. Glutamate, AP5 and NMDA do not directly modulate glycine receptors. Molecular Pharmacology. PMID 33051383 DOI: 10.1124/molpharm.120.000127  1
2020 Gallagher CI, Sheipouri D, Shimmon S, Rawling T, Vandenberg RJ. Identification of N-acyl amino acids that are positive allosteric modulators of glycine receptors. Biochemical Pharmacology. 114117. PMID 32579961 DOI: 10.1016/j.bcp.2020.114117  0.76
2020 Mostyn SN, Sarker S, Muthuraman P, Raja A, Shimmon S, Rawling T, Cioffi CL, Vandenberg RJ. A photoswitchable ORG25543 congener enables optical control of glycine transporter 2. Acs Chemical Neuroscience. PMID 32191428 DOI: 10.1021/acschemneuro.9b00655  0.76
2020 Freidman N, Chen I, Wu Q, Briot C, Holst J, Font J, Vandenberg R, Ryan R. Amino Acid Transporters and Exchangers from the SLC1A Family: Structure, Mechanism and Roles in Physiology and Cancer. Neurochemical Research. PMID 31981058 DOI: 10.1007/s11064-019-02934-x  0.4
2019 Mostyn SN, Wilson KA, Schumann-Gillett A, Frangos ZJ, Shimmon S, Rawling T, Ryan RM, O'Mara ML, Vandenberg RJ. Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics. Elife. 8. PMID 31621581 DOI: 10.7554/eLife.47150  0.8
2019 Mostyn SN, Rawling T, Mohammadi S, Shimmon S, Frangos ZJ, Sarker S, Yousuf A, Vetter I, Ryan RM, Christie MJ, Vandenberg RJ. Development of an N-acyl amino acid that selectively inhibits the glycine transporter 2 to produce analgesia in a rat model of chronic pain. Journal of Medicinal Chemistry. PMID 30714733 DOI: 10.1021/acs.jmedchem.8b01775  0.8
2018 Winters BL, Rawling T, Vandenberg RJ, Christie MJ, Bhola RF, Imlach WL. Activity of novel lipid glycine transporter inhibitors on synaptic signalling in the dorsal horn of the spinal cord. British Journal of Pharmacology. PMID 29500820 DOI: 10.1111/bph.14189  0.76
2018 Scopelliti AJ, Font J, Vandenberg RJ, Boudker O, Ryan RM. Structural characterisation reveals insights into substrate recognition by the glutamine transporter ASCT2/SLC1A5. Nature Communications. 9: 38. PMID 29295993 DOI: 10.1038/s41467-017-02444-w  0.8
2017 Carland JE, Thomas M, Mostyn SN, Subramanian N, O'Mara ML, Ryan RM, Vandenberg RJ. Molecular Determinants for Substrate Interactions with the Glycine Transporter GlyT2. Acs Chemical Neuroscience. PMID 29120604 DOI: 10.1021/acschemneuro.7b00407  0.8
2017 Mostyn SN, Carland JE, Shimmon S, Ryan RM, Rawling T, Vandenberg RJ. Synthesis and Characterization of Novel Acyl-Glycine Inhibitors of GlyT2. Acs Chemical Neuroscience. PMID 28574249 DOI: 10.1021/acschemneuro.7b00105  0.8
2016 Krycer JR, Fazakerley DJ, Cater RJ, Thomas K, Naghiloo S, Burchfield JG, Humphrey SJ, Vandenberg RJ, Ryan RM, James DE. The amino acid transporter SLC1A3 is plasma membrane-localised in adipocytes and its activity is insensitive to insulin. Febs Letters. PMID 28032905 DOI: 10.1002/1873-3468.12549  0.8
2016 McIlwain BC, Vandenberg RJ, Ryan RM. Characterization of the Inward- and Outward-Facing Substrate Binding Sites of the Prokaryotic Aspartate Transporter, GltPh. Biochemistry. 55: 6801-6810. PMID 27951659 DOI: 10.1021/acs.biochem.6b00795  0.8
2016 Subramanian N, Scopelliti AJ, Carland JE, Ryan RM, O'Mara ML, Vandenberg RJ. Correction: Identification of a 3rd Na+ Binding Site of the Glycine Transporter, GlyT2. Plos One. 11: e0159896. PMID 27434127 DOI: 10.1371/journal.pone.0159896  0.8
2016 Subramanian N, Scopelitti AJ, Carland JE, Ryan RM, O'Mara ML, Vandenberg RJ. Identification of a 3rd Na+ Binding Site of the Glycine Transporter, GlyT2. Plos One. 11: e0157583. PMID 27337045 DOI: 10.1371/journal.pone.0157583  0.8
2016 Cater RJ, Vandenberg RJ, Ryan RM. Tuning the ion selectivity of glutamate transporter-associated uncoupled conductances. The Journal of General Physiology. PMID 27296367 DOI: 10.1085/jgp.201511556  0.8
2016 Ryan RM, Vandenberg RJ. Elevating the alternating-access model. Nature Structural & Molecular Biology. 23: 187-9. PMID 26931415 DOI: 10.1038/nsmb.3179  1
2015 Vandenberg RJ, Mostyn SN, Carland JE, Ryan RM. Glycine Transporter2 Inhibitors: Getting the balance right. Neurochemistry International. PMID 26723543 DOI: 10.1016/j.neuint.2015.12.007  1
2015 Cater RJ, Ryan RM, Vandenberg RJ. The Split Personality of Glutamate Transporters: A Chloride Channel and a Transporter. Neurochemical Research. PMID 26303507 DOI: 10.1007/s11064-015-1699-6  1
2015 McIlwain BC, Vandenberg RJ, Ryan RM. Transport rates of a glutamate transporter homologue are influenced by the lipid bilayer. The Journal of Biological Chemistry. 290: 9780-8. PMID 25713135 DOI: 10.1074/jbc.M114.630590  1
2014 Cater RJ, Vandenberg RJ, Ryan RM. The domain interface of the human glutamate transporter EAAT1 mediates chloride permeation. Biophysical Journal. 107: 621-9. PMID 25099801 DOI: 10.1016/j.bpj.2014.05.046  1
2014 Vandenberg RJ, Ryan RM, Carland JE, Imlach WL, Christie MJ. Glycine transport inhibitors for the treatment of pain. Trends in Pharmacological Sciences. 35: 423-30. PMID 24962068 DOI: 10.1016/  1
2014 Scopelliti AJ, Heinzelmann G, Kuyucak S, Ryan RM, Vandenberg RJ. Na+ interactions with the neutral amino acid transporter ASCT1. The Journal of Biological Chemistry. 289: 17468-79. PMID 24808181 DOI: 10.1074/jbc.M114.565242  1
2014 Carland JE, Handford CA, Ryan RM, Vandenberg RJ. Lipid inhibitors of high affinity glycine transporters: identification of a novel class of analgesics. Neurochemistry International. 73: 211-6. PMID 24036283 DOI: 10.1016/j.neuint.2013.08.012  1
2013 Vandenberg RJ, Ryan RM. Mechanisms of glutamate transport. Physiological Reviews. 93: 1621-57. PMID 24137018 DOI: 10.1152/physrev.00007.2013  1
2013 Scopelliti AJ, Ryan RM, Vandenberg RJ. Molecular determinants for functional differences between alanine-serine-cysteine transporter 1 and other glutamate transporter family members. The Journal of Biological Chemistry. 288: 8250-7. PMID 23393130 DOI: 10.1074/jbc.M112.441022  1
2013 Carland JE, Mansfield RE, Ryan RM, Vandenberg RJ. Oleoyl-L-carnitine inhibits glycine transport by GlyT2. British Journal of Pharmacology. 168: 891-902. PMID 22978602 DOI: 10.1111/j.1476-5381.2012.02213.x  1
2012 Bastug T, Heinzelmann G, Kuyucak S, Salim M, Vandenberg RJ, Ryan RM. Position of the third Na+ site in the aspartate transporter GltPh and the human glutamate transporter, EAAT1. Plos One. 7: e33058. PMID 22427946 DOI: 10.1371/journal.pone.0033058  1
2011 Vandenberg RJ, Handford CA, Campbell EM, Ryan RM, Yool AJ. Water and urea permeation pathways of the human excitatory amino acid transporter EAAT1. The Biochemical Journal. 439: 333-40. PMID 21732909 DOI: 10.1042/BJ20110905  1
2011 Bailey CG, Ryan RM, Thoeng AD, Ng C, King K, Vanslambrouck JM, Auray-Blais C, Vandenberg RJ, Bröer S, Rasko JE. Loss-of-function mutations in the glutamate transporter SLC1A1 cause human dicarboxylic aminoaciduria. The Journal of Clinical Investigation. 121: 446-53. PMID 21123949 DOI: 10.1172/JCI44474  1
2011 Scott HA, Gebhardt FM, Mitrovic AD, Vandenberg RJ, Dodd PR. Glutamate transporter variants reduce glutamate uptake in Alzheimer's disease. Neurobiology of Aging. 32: 553.e1-11. PMID 20416976 DOI: 10.1016/j.neurobiolaging.2010.03.008  1
2010 Jeong HJ, Vandenberg RJ, Vaughan CW. N-arachidonyl-glycine modulates synaptic transmission in superficial dorsal horn. British Journal of Pharmacology. 161: 925-35. PMID 20860669 DOI: 10.1111/j.1476-5381.2010.00935.x  1
2010 Gebhardt FM, Mitrovic AD, Gilbert DF, Vandenberg RJ, Lynch JW, Dodd PR. Exon-skipping splice variants of excitatory amino acid transporter-2 (EAAT2) form heteromeric complexes with full-length EAAT2. The Journal of Biological Chemistry. 285: 31313-24. PMID 20688910 DOI: 10.1074/jbc.M110.153494  1
2010 Connor M, Vaughan CW, Vandenberg RJ. N-acyl amino acids and N-acyl neurotransmitter conjugates: neuromodulators and probes for new drug targets. British Journal of Pharmacology. 160: 1857-71. PMID 20649585 DOI: 10.1111/j.1476-5381.2010.00862.x  1
2010 Ryan RM, Kortt NC, Sirivanta T, Vandenberg RJ. The position of an arginine residue influences substrate affinity and K+ coupling in the human glutamate transporter, EAAT1. Journal of Neurochemistry. 114: 565-75. PMID 20477940 DOI: 10.1111/j.1471-4159.2010.06796.x  1
2010 McKinzie AA, Ryan RM, Vandenberg RJ. Site-directed mutagenesis in the study of membrane transporters. Methods in Molecular Biology (Clifton, N.J.). 637: 277-93. PMID 20419441 DOI: 10.1007/978-1-60761-700-6_15  1
2009 Edington AR, McKinzie AA, Reynolds AJ, Kassiou M, Ryan RM, Vandenberg RJ. Extracellular loops 2 and 4 of GLYT2 are required for N-arachidonylglycine inhibition of glycine transport. The Journal of Biological Chemistry. 284: 36424-30. PMID 19875446 DOI: 10.1074/jbc.M109.017509  1
2009 Habjan S, Vandenberg RJ. Modulation of glutamate and glycine transporters by niflumic, flufenamic and mefenamic acids. Neurochemical Research. 34: 1738-47. PMID 19444608 DOI: 10.1007/s11064-009-9983-y  1
2009 Liu X, Mitrovic AD, Vandenberg RJ. Glycine transporter 1 associates with cholesterol-rich membrane raft microdomains. Biochemical and Biophysical Research Communications. 384: 530-4. PMID 19427831 DOI: 10.1016/j.bbrc.2009.05.014  1
2009 Huang S, Ryan RM, Vandenberg RJ. The role of cation binding in determining substrate selectivity of glutamate transporters. The Journal of Biological Chemistry. 284: 4510-5. PMID 19074430 DOI: 10.1074/jbc.M808495200  1
2008 Yang Z, Aubrey KR, Alroy I, Harvey RJ, Vandenberg RJ, Lynch JW. Subunit-specific modulation of glycine receptors by cannabinoids and N-arachidonyl-glycine. Biochemical Pharmacology. 76: 1014-23. PMID 18755158 DOI: 10.1016/j.bcp.2008.07.037  1
2008 Vandenberg RJ, Huang S, Ryan RM. Slips, leaks and channels in glutamate transporters. Channels (Austin, Tex.). 2: 51-8. PMID 18690049 DOI: 10.4161/chan.2.1.6047  1
2007 Huang S, Vandenberg RJ. Mutations in transmembrane domains 5 and 7 of the human excitatory amino acid transporter 1 affect the substrate-activated anion channel. Biochemistry. 46: 9685-92. PMID 17676873 DOI: 10.1021/bi700647f  1
2007 Vandenberg RJ, Shaddick K, Ju P. Molecular basis for substrate discrimination by glycine transporters. The Journal of Biological Chemistry. 282: 14447-53. PMID 17383967 DOI: 10.1074/jbc.M609158200  1
2006 Wiles AL, Pearlman RJ, Rosvall M, Aubrey KR, Vandenberg RJ. N-Arachidonyl-glycine inhibits the glycine transporter, GLYT2a. Journal of Neurochemistry. 99: 781-6. PMID 16899062 DOI: 10.1111/j.1471-4159.2006.04107.x  1
2006 Vandenberg RJ. Mutational analysis of glutamate transporters. Handbook of Experimental Pharmacology. 113-35. PMID 16722233 DOI: 10.1007/3-540-29784-7-6  1
2005 Aubrey KR, Vandenberg RJ, Clements JD. Dynamics of forward and reverse transport by the glial glycine transporter, glyt1b. Biophysical Journal. 89: 1657-68. PMID 15951392 DOI: 10.1529/biophysj.105.061572  1
2005 Vandenberg RJ, Ryan RM. How and why are channels in transporters? Science's Stke : Signal Transduction Knowledge Environment. 2005: pe17. PMID 15840837 DOI: 10.1126/stke.2802005pe17  1
2005 Ryan RM, Vandenberg RJ. A channel in a transporter. Clinical and Experimental Pharmacology & Physiology. 32: 1-6. PMID 15730426 DOI: 10.1111/j.1440-1681.2005.04164.x  1
2004 Vandenberg RJ, Ju P, Aubrey KR, Ryan RM, Mitrovic AD. Allosteric modulation of neurotransmitter transporters at excitatory synapses. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 23: 1-11. PMID 15324920 DOI: 10.1016/j.ejps.2004.05.006  1
2004 Liu L, Markus I, Vandenberg RJ, Neilan BA, Murray M, Burcher E. Molecular identification and characterization of three isoforms of tachykinin NK(1)-like receptors in the cane toad Bufo marinus. American Journal of Physiology. Regulatory, Integrative and Comparative Physiology. 287: R575-85. PMID 15155274 DOI: 10.1152/ajpregu.00051.2004  1
2004 Ju P, Aubrey KR, Vandenberg RJ. Zn2+ inhibits glycine transport by glycine transporter subtype 1b. The Journal of Biological Chemistry. 279: 22983-91. PMID 15031290 DOI: 10.1074/jbc.M312484200  1
2004 Ryan RM, Mitrovic AD, Vandenberg RJ. The chloride permeation pathway of a glutamate transporter and its proximity to the glutamate translocation pathway. The Journal of Biological Chemistry. 279: 20742-51. PMID 14982939 DOI: 10.1074/jbc.M304433200  1
2003 Ryan RM, Mitrovic AD, Vandenberg RJ. Site-directed mutagenesis in the study of membrane transporters. Methods in Molecular Biology (Clifton, N.J.). 227: 97-108. PMID 12824646 DOI: 10.1385/1-59259-387-9:97  0.8
2003 Pearlman RJ, Aubrey KR, Vandenberg RJ. Arachidonic acid and anandamide have opposite modulatory actions at the glycine transporter, GLYT1a. Journal of Neurochemistry. 84: 592-601. PMID 12558979 DOI: 10.1046/j.1471-4159.2003.01549.x  1
2002 Moussa Cel-H, Mitrovic AD, Vandenberg RJ, Provis T, Rae C, Bubb WA, Balcar VJ. Effects of L-glutamate transport inhibition by a conformationally restricted glutamate analogue (2S,1'S,2'R)-2-(carboxycyclopropyl)glycine (L-CCG III) on metabolism in brain tissue in vitro analysed by NMR spectroscopy. Neurochemical Research. 27: 27-35. PMID 11926273 DOI: 10.1023/A:1014842303583  1
2002 Ryan RM, Vandenberg RJ. Distinct conformational states mediate the transport and anion channel properties of the glutamate transporter EAAT-1. The Journal of Biological Chemistry. 277: 13494-500. PMID 11815608 DOI: 10.1074/jbc.M109970200  1
2001 Vandenberg RJ, Aubrey KR. Glycine transport inhibitors as potential antipsychotic drugs. Expert Opinion On Therapeutic Targets. 5: 507-518. PMID 12540263 DOI: 10.1517/14728222.5.4.507  1
2001 Aubrey KR, Vandenberg RJ. N[3-(4'-fluorophenyl)-3-(4'-phenylphenoxy)propyl]sarcosine (NFPS) is a selective persistent inhibitor of glycine transport. British Journal of Pharmacology. 134: 1429-36. PMID 11724748 DOI: 10.1038/sj.bjp.0704381  1
2001 Poulsen MV, Vandenberg RJ. Niflumic acid modulates uncoupled substrate-gated conductances in the human glutamate transporter EAAT4. The Journal of Physiology. 534: 159-67. PMID 11432999 DOI: 10.1111/j.1469-7793.2001.00159.x  1
2001 Mitrovic AD, Plesko F, Vandenberg RJ. Zn(2+) inhibits the anion conductance of the glutamate transporter EEAT4. The Journal of Biological Chemistry. 276: 26071-6. PMID 11352900 DOI: 10.1074/jbc.M011318200  1
2001 Vandenberg RJ, Aubrey KR. Central and peripheral nervous system: Glycine transport inhibitors as potential antipsychotic drugs Expert Opinion On Therapeutic Targets. 5: 507-518.  1
2000 Dutton JL, Poronnik P, Li GH, Holding CA, Worthington RA, Vandenberg RJ, Cook DI, Barden JA, Bennett MR. P2X(1) receptor membrane redistribution and down-regulation visualized by using receptor-coupled green fluorescent protein chimeras. Neuropharmacology. 39: 2054-66. PMID 10963749 DOI: 10.1016/S0028-3908(00)00058-7  1
2000 Aubrey KR, Mitrovic AD, Vandenberg RJ. Molecular basis for proton regulation of glycine transport by glycine transporter subtype 1b. Molecular Pharmacology. 58: 129-35. PMID 10860934  1
1999 Johnston GAR, Chebib M, Duke RK, Mewett KN, Mitrovic AD, Vandenberg RJ. Medicinal chemistry and molecular pharmacology of GABA receptors and glutamate transporters - Complementary structure-activity relationships Drug Development Research. 46: 255-260. DOI: 10.1002/(SICI)1098-2299(199903/04)46:3/4<255::AID-DDR10>3.0.CO;2-S  1
1998 Vandenberg RJ. Molecular pharmacology and physiology of glutamate transporters in the central nervous system. Clinical and Experimental Pharmacology & Physiology. 25: 393-400. PMID 9673812  1
1998 Vandenberg RJ, Mitrovic AD, Johnston GA. Molecular basis for differential inhibition of glutamate transporter subtypes by zinc ions. Molecular Pharmacology. 54: 189-96. PMID 9658205  1
1998 Mitrovic AD, Amara SG, Johnston GA, Vandenberg RJ. Identification of functional domains of the human glutamate transporters EAAT1 and EAAT2. The Journal of Biological Chemistry. 273: 14698-706. PMID 9614067 DOI: 10.1074/jbc.273.24.14698  1
1998 Vandenberg RJ, Mitrovic AD, Johnston GA. Serine-O-sulphate transport by the human glutamate transporter, EAAT2. British Journal of Pharmacology. 123: 1593-600. PMID 9605566 DOI: 10.1038/sj.bjp.0701776  1
1997 Chebib M, Vandenberg RJ, Johnston GA. Analogues of gamma-aminobutyric acid (GABA) and trans-4-aminocrotonic acid (TACA) substituted in the 2 position as GABAC receptor antagonists. British Journal of Pharmacology. 122: 1551-60. PMID 9422798 DOI: 10.1038/sj.bjp.0701533  1
1997 Chebib M, Vandenberg RJ, Froestl W, Johnston GA. Unsaturated phosphinic analogues of gamma-aminobutyric acid as GABA(C) receptor antagonists. European Journal of Pharmacology. 329: 223-9. PMID 9226416 DOI: 10.1016/S0014-2999(97)10121-2  1
1997 Vandenberg RJ, Mitrovic AD, Chebib M, Balcar VJ, Johnston GA. Contrasting modes of action of methylglutamate derivatives on the excitatory amino acid transporters, EAAT1 and EAAT2. Molecular Pharmacology. 51: 809-15. PMID 9145919  1
1995 Fairman WA, Vandenberg RJ, Arriza JL, Kavanaugh MP, Amara SG. An excitatory amino-acid transporter with properties of a ligand-gated chloride channel. Nature. 375: 599-603. PMID 7791878 DOI: 10.1038/375599a0  1
1995 Vandenberg RJ, Arriza JL, Amara SG, Kavanaugh MP. Constitutive ion fluxes and substrate binding domains of human glutamate transporters. The Journal of Biological Chemistry. 270: 17668-71. PMID 7629063 DOI: 10.1074/jbc.270.30.17668  1
1995 Rajendra S, Vandenberg RJ, Pierce KD, Cunningham AM, French PW, Barry PH, Schofield PR. The unique extracellular disulfide loop of the glycine receptor is a principal ligand binding element. The Embo Journal. 14: 2987-98. PMID 7621814  1
1993 Vandenberg RJ, Rajendra S, French CR, Barry PH, Schofield PR. The extracellular disulfide loop motif of the inhibitory glycine receptor does not form the agonist binding site. Molecular Pharmacology. 44: 198-203. PMID 8393521  1
1993 Vandenberg RJ, Schofield PR. The importance of being inhibited: Brain GABA(A) and glycine receptors Today's Life Science. 5: 20-26.  1
1992 Vandenberg RJ, Handford CA, Schofield PR. Distinct agonist- and antagonist-binding sites on the glycine receptor. Neuron. 9: 491-6. PMID 1326295 DOI: 10.1016/0896-6273(92)90186-H  1
1992 Vandenberg RJ, French CR, Barry PH, Shine J, Schofield PR. Antagonism of ligand-gated ion channel receptors: two domains of the glycine receptor alpha subunit form the strychnine-binding site. Proceedings of the National Academy of Sciences of the United States of America. 89: 1765-9. PMID 1311851  1
1988 Easterbrook-Smith SB, Vandenberg RJ, Alden JR. The role of Fc:Fc interactions in insoluble immune complex formation and complement activation. Molecular Immunology. 25: 1331-7. PMID 3237216 DOI: 10.1016/0161-5890(88)90048-X  1
1987 Vandenberg RJ, Easterbrook-Smith SB. Activation of the classical complement pathway by BioRex-70. Immunology Letters. 14: 155-8. PMID 3495488 DOI: 10.1016/0165-2478(87)90095-2  1
1986 Vandenberg RJ, Easterbrook-Smith SB. Conformational changes in C1q upon binding to IgG oligomers. Febs Letters. 207: 276-9. PMID 3490402 DOI: 10.1016/0014-5793(86)81504-6  1
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