| Year |
Citation |
Score |
| 2023 |
Burgio AL, Shrader CW, Kharel Y, Huang T, Salamoun JM, Lynch KR, Santos WL. 2-Aminobenzoxazole Derivatives as Potent Inhibitors of the Sphingosine-1-Phosphate Transporter Spinster Homolog 2 (Spns2). Journal of Medicinal Chemistry. PMID 37010497 DOI: 10.1021/acs.jmedchem.3c00149 |
0.352 |
|
| 2022 |
Pashikanti S, Foster DJ, Kharel Y, Brown AM, Bevan DR, Lynch KR, Santos WL. Sphingosine Kinase 2 Inhibitors: Rigid Aliphatic Tail Derivatives Deliver Potent and Selective Analogues. Acs Bio & Med Chem Au. 2: 469-489. PMID 36281302 DOI: 10.1021/acsbiomedchemau.2c00017 |
0.352 |
|
| 2022 |
Fritzemeier R, Foster D, Peralta A, Payette M, Kharel Y, Huang T, Lynch KR, Santos WL. Discovery of In Vivo Active Sphingosine-1-phosphate Transporter (Spns2) Inhibitors. Journal of Medicinal Chemistry. PMID 35609189 DOI: 10.1021/acs.jmedchem.1c02171 |
0.307 |
|
| 2020 |
Kharel Y, Huang T, Salamon A, Harris T, Santos WL, Lynch KR. Mechanism of sphingosine 1-phosphate clearance from blood. The Biochemical Journal. PMID 32065229 DOI: 10.1042/Bcj20190730 |
0.386 |
|
| 2020 |
Sibley CD, Morris EA, Kharel Y, Brown AM, Bevan DR, Lynch KR, Santos WL. Discovery of a Small Side Cavity in Sphingosine Kinase 2 that Enhances Inhibitor Potency and Selectivity. Journal of Medicinal Chemistry. PMID 31895563 DOI: 10.1021/Acs.Jmedchem.9B01508 |
0.399 |
|
| 2018 |
Kharel Y, Agah S, Huang T, Mendelson AJ, Eletu OT, Barkey-Bircann P, Gesualdi J, Smith JS, Santos WL, Lynch KR. Saccharomyces cerevisiae as a platform for assessing sphingolipid lipid kinase inhibitors. Plos One. 13: e0192179. PMID 29672528 DOI: 10.1371/Journal.Pone.0192179 |
0.331 |
|
| 2017 |
Adamiak M, Chelvarajan L, Lynch KR, Santos WL, Abdel-Latif A, Ratajczak MZ. Mobilization studies in mice deficient in sphingosine kinase 2 support a crucial role of the plasma level of sphingosine-1-phosphate in the egress of hematopoietic stem progenitor cells. Oncotarget. 8: 65588-65600. PMID 29029455 DOI: 10.18632/Oncotarget.19514 |
0.372 |
|
| 2017 |
Childress ES, Kharel Y, Brown AM, Bevan DR, Lynch KR, Santos WL. Transforming Sphingosine Kinase 1 Inhibitors into Dual and Sphingosine Kinase 2 Selective Inhibitors: Design, Synthesis, and In Vivo Activity. Journal of Medicinal Chemistry. PMID 28406646 DOI: 10.1021/Acs.Jmedchem.7B00233 |
0.433 |
|
| 2016 |
Lynch KR, Thorpe SB, Santos WL. Sphingosine kinase inhibitors: a review of patent literature (2006-2015). Expert Opinion On Therapeutic Patents. PMID 27539678 DOI: 10.1080/13543776.2016.1226282 |
0.354 |
|
| 2016 |
Houck JD, Dawson TK, Kennedy AJ, Kharel Y, Naimon ND, Field SD, Lynch KR, Macdonald TL. Structural Requirements and Docking Analysis of Amidine-Based Sphingosine Kinase 1 Inhibitors Containing Oxadiazoles. Acs Medicinal Chemistry Letters. 7: 487-92. PMID 27190598 DOI: 10.1021/Acsmedchemlett.6B00002 |
0.37 |
|
| 2016 |
Congdon MD, Kharel Y, Brown AM, Lewis SN, Bevan DR, Lynch KR, Santos WL. Structure-Activity Relationship Studies and Molecular Modeling of Naphthalene-Based Sphingosine Kinase 2 Inhibitors. Acs Medicinal Chemistry Letters. 7: 229-34. PMID 26985306 DOI: 10.1021/Acsmedchemlett.5B00304 |
0.37 |
|
| 2016 |
Perry HM, Huang L, Ye H, Liu C, Sung SJ, Lynch KR, Rosin DL, Bajwa A, Okusa MD. Endothelial Sphingosine 1‑Phosphate Receptor‑1 Mediates Protection and Recovery from Acute Kidney Injury. Journal of the American Society of Nephrology : Jasn. PMID 26961351 DOI: 10.1681/Asn.2015080922 |
0.357 |
|
| 2015 |
Kharel Y, Morris EA, Congdon MD, Thorpe SB, Tomsig JL, Santos WL, Lynch KR. Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels. The Journal of Pharmacology and Experimental Therapeutics. 355: 23-31. PMID 26243740 DOI: 10.1124/Jpet.115.225862 |
0.38 |
|
| 2015 |
Stone ML, Sharma AK, Zhao Y, Charles EJ, Huerter ME, Johnston WF, Kron IL, Lynch KR, Laubach VE. Sphingosine-1-phosphate receptor 1 agonism attenuates lung ischemia-reperfusion injury. American Journal of Physiology. Lung Cellular and Molecular Physiology. 308: L1245-52. PMID 25910934 DOI: 10.1152/Ajplung.00302.2014 |
0.37 |
|
| 2015 |
Congdon MD, Childress ES, Patwardhan NN, Gumkowski J, Morris EA, Kharel Y, Lynch KR, Santos WL. Structure-activity relationship studies of the lipophilic tail region of sphingosine kinase 2 inhibitors. Bioorganic & Medicinal Chemistry Letters. PMID 25862200 DOI: 10.1016/J.Bmcl.2015.03.041 |
0.392 |
|
| 2015 |
Patwardhan NN, Morris EA, Kharel Y, Raje MR, Gao M, Tomsig JL, Lynch KR, Santos WL. Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors. Journal of Medicinal Chemistry. 58: 1879-99. PMID 25643074 DOI: 10.1021/Jm501760D |
0.444 |
|
| 2015 |
Santos WL, Lynch KR. Drugging sphingosine kinases. Acs Chemical Biology. 10: 225-33. PMID 25384187 DOI: 10.1021/Cb5008426 |
0.376 |
|
| 2015 |
Bajwa A, Rosin DL, Chroscicki P, Lee S, Dondeti K, Ye H, Kinsey GR, Stevens BK, Jobin K, Kenwood BM, Hoehn KL, Lynch KR, Okusa MD. Sphingosine 1-phosphate receptor-1 enhances mitochondrial function and reduces cisplatin-induced tubule injury. Journal of the American Society of Nephrology : Jasn. 26: 908-25. PMID 25145931 DOI: 10.1681/Asn.2013121351 |
0.541 |
|
| 2014 |
Ogle ME, Sefcik LS, Awojoodu AO, Chiappa NF, Lynch K, Peirce-Cottler S, Botchwey EA. Engineering in vivo gradients of sphingosine-1-phosphate receptor ligands for localized microvascular remodeling and inflammatory cell positioning. Acta Biomaterialia. 10: 4704-14. PMID 25128750 DOI: 10.1016/J.Actbio.2014.08.007 |
0.4 |
|
| 2014 |
Awojoodu AO, Keegan PM, Lane AR, Zhang Y, Lynch KR, Platt MO, Botchwey EA. Acid sphingomyelinase is activated in sickle cell erythrocytes and contributes to inflammatory microparticle generation in SCD. Blood. 124: 1941-50. PMID 25075126 DOI: 10.1182/Blood-2014-01-543652 |
0.418 |
|
| 2013 |
Awojoodu AO, Ogle ME, Sefcik LS, Bowers DT, Martin K, Brayman KL, Lynch KR, Peirce-Cottler SM, Botchwey E. Sphingosine 1-phosphate receptor 3 regulates recruitment of anti-inflammatory monocytes to microvessels during implant arteriogenesis. Proceedings of the National Academy of Sciences of the United States of America. 110: 13785-90. PMID 23918395 DOI: 10.1073/Pnas.1221309110 |
0.363 |
|
| 2013 |
Raines TA, Lynch KR, Slack-Davis JK. Abstract 2805: LPA-dependent regulation of VCAM-1 in the ovarian cancer metastatic microenvironment and its impact on mesothelial invasion. Cancer Research. 73: 2805-2805. DOI: 10.1158/1538-7445.Am2013-2805 |
0.34 |
|
| 2012 |
Bajwa A, Huang L, Ye H, Dondeti K, Song S, Rosin DL, Lynch KR, Lobo PI, Li L, Okusa MD. Dendritic cell sphingosine 1-phosphate receptor-3 regulates Th1-Th2 polarity in kidney ischemia-reperfusion injury. Journal of Immunology (Baltimore, Md. : 1950). 189: 2584-96. PMID 22855711 DOI: 10.4049/Jimmunol.1200999 |
0.344 |
|
| 2012 |
Kharel Y, Raje M, Gao M, Gellett AM, Tomsig JL, Lynch KR, Santos WL. Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate. The Biochemical Journal. 447: 149-57. PMID 22747486 DOI: 10.1042/Bj20120609 |
0.789 |
|
| 2012 |
Gellett AM, Kharel Y, Sunkara M, Morris AJ, Lynch KR. Biosynthesis of alkyl lysophosphatidic acid by diacylglycerol kinases. Biochemical and Biophysical Research Communications. 422: 758-63. PMID 22627129 DOI: 10.1016/J.Bbrc.2012.05.077 |
0.786 |
|
| 2012 |
Lynch KR. Building a better sphingosine kinase-1 inhibitor. The Biochemical Journal. 444: e1-2. PMID 22533672 DOI: 10.1042/Bj20120567 |
0.428 |
|
| 2012 |
Knott K, Kharel Y, Raje MR, Lynch KR, Santos WL. Effect of alkyl chain length on sphingosine kinase 2 selectivity. Bioorganic & Medicinal Chemistry Letters. 22: 6817-20. PMID 22321213 DOI: 10.1016/J.Bmcl.2012.01.050 |
0.341 |
|
| 2012 |
Raje MR, Knott K, Kharel Y, Bissel P, Lynch KR, Santos WL. Design, synthesis and biological activity of sphingosine kinase 2 selective inhibitors. Bioorganic & Medicinal Chemistry. 20: 183-94. PMID 22137932 DOI: 10.1016/J.Bmc.2011.11.011 |
0.377 |
|
| 2012 |
Callihan P, Zitomer NC, Stoeling MV, Kennedy PC, Lynch KR, Riley RT, Hooks SB. Distinct generation, pharmacology, and distribution of sphingosine 1-phosphate and dihydrosphingosine 1-phosphate in human neural progenitor cells. Neuropharmacology. 62: 988-96. PMID 22016110 DOI: 10.1016/J.Neuropharm.2011.10.005 |
0.789 |
|
| 2011 |
East JE, Carter KM, Kennedy PC, Schulte NA, Toews ML, Lynch KR, Macdonald TL. Development of a phosphatase-resistant, L-tyrosine derived LPA1/LPA3 dual antagonist. Medchemcomm. 2: 325-330. PMID 22180836 DOI: 10.1039/C0Md00273A |
0.642 |
|
| 2011 |
Kharel Y, Mathews TP, Gellett AM, Tomsig JL, Kennedy PC, Moyer ML, Macdonald TL, Lynch KR. Sphingosine kinase type 1 inhibition reveals rapid turnover of circulating sphingosine 1-phosphate. The Biochemical Journal. 440: 345-53. PMID 21848514 DOI: 10.1042/Bj20110817 |
0.791 |
|
| 2011 |
Kennedy PC, Zhu R, Huang T, Tomsig JL, Mathews TP, David M, Peyruchaud O, Macdonald TL, Lynch KR. Characterization of a sphingosine 1-phosphate receptor antagonist prodrug. The Journal of Pharmacology and Experimental Therapeutics. 338: 879-89. PMID 21632869 DOI: 10.1124/Jpet.111.181552 |
0.715 |
|
| 2011 |
Kennedy AJ, Mathews TP, Kharel Y, Field SD, Moyer ML, East JE, Houck JD, Lynch KR, Macdonald TL. Development of amidine-based sphingosine kinase 1 nanomolar inhibitors and reduction of sphingosine 1-phosphate in human leukemia cells. Journal of Medicinal Chemistry. 54: 3524-48. PMID 21495716 DOI: 10.1021/Jm2001053 |
0.391 |
|
| 2011 |
Awad AS, Rouse MD, Khutsishvili K, Huang L, Bolton WK, Lynch KR, Okusa MD. Chronic sphingosine 1-phosphate 1 receptor activation attenuates early-stage diabetic nephropathy independent of lymphocytes. Kidney International. 79: 1090-8. PMID 21289599 DOI: 10.1038/Ki.2010.544 |
0.393 |
|
| 2011 |
Kharel Y, Mathews TP, Kennedy AJ, Houck JD, Macdonald TL, Lynch KR. A rapid assay for assessment of sphingosine kinase inhibitors and substrates. Analytical Biochemistry. 411: 230-5. PMID 21216217 DOI: 10.1016/J.Ab.2011.01.003 |
0.347 |
|
| 2011 |
Sefcik LS, Aronin CE, Awojoodu AO, Shin SJ, Mac Gabhann F, MacDonald TL, Wamhoff BR, Lynch KR, Peirce SM, Botchwey EA. Selective activation of sphingosine 1-phosphate receptors 1 and 3 promotes local microvascular network growth. Tissue Engineering. Part A. 17: 617-29. PMID 20874260 DOI: 10.1089/Ten.Tea.2010.0404 |
0.433 |
|
| 2010 |
Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacological Reviews. 62: 579-87. PMID 21079037 DOI: 10.1124/Pr.110.003111 |
0.522 |
|
| 2010 |
East JE, Kennedy AJ, Tomsig JL, De Leon AR, Lynch KR, Macdonald TL. Synthesis and structure-activity relationships of tyrosine-based inhibitors of autotaxin (ATX). Bioorganic & Medicinal Chemistry Letters. 20: 7132-6. PMID 20951039 DOI: 10.1016/J.Bmcl.2010.09.030 |
0.32 |
|
| 2010 |
Bajwa A, Jo SK, Ye H, Huang L, Dondeti KR, Rosin DL, Haase VH, Macdonald TL, Lynch KR, Okusa MD. Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury. Journal of the American Society of Nephrology : Jasn. 21: 955-65. PMID 20338995 DOI: 10.1681/Asn.2009060662 |
0.377 |
|
| 2010 |
Mathews TP, Kennedy AJ, Kharel Y, Kennedy PC, Nicoara O, Sunkara M, Morris AJ, Wamhoff BR, Lynch KR, Macdonald TL. Discovery, biological evaluation, and structure-activity relationship of amidine based sphingosine kinase inhibitors. Journal of Medicinal Chemistry. 53: 2766-78. PMID 20205392 DOI: 10.1021/Jm901860H |
0.64 |
|
| 2010 |
Ma B, Guckian KM, Lin EY, Lee WC, Scott D, Kumaravel G, Macdonald TL, Lynch KR, Black C, Chollate S, Hahm K, Hetu G, Jin P, Luo Y, Rohde E, et al. Stereochemistry-activity relationship of orally active tetralin S1P agonist prodrugs. Bioorganic & Medicinal Chemistry Letters. 20: 2264-9. PMID 20188554 DOI: 10.1016/J.Bmcl.2010.02.006 |
0.455 |
|
| 2010 |
Petrie Aronin CE, Sefcik LS, Tholpady SS, Tholpady A, Sadik KW, Macdonald TL, Peirce SM, Wamhoff BR, Lynch KR, Ogle RC, Botchwey EA. FTY720 promotes local microvascular network formation and regeneration of cranial bone defects. Tissue Engineering. Part A. 16: 1801-9. PMID 20038198 DOI: 10.1089/Ten.Tea.2009.0539 |
0.363 |
|
| 2010 |
Bajwa A, Jo S, Ye H, Huang L, Dondeti KR, Rosin DL, Haase VH, Macdonald TL, Lynch KR, Okusa MD. 42: Activation of Proximal Tubule Sphingosine 1-Phosphate Receptor 1 Protects Kidneys From Ischemia Reperfusion Injury Independent of Lymphocytes American Journal of Kidney Diseases. 55: B42. DOI: 10.1053/J.Ajkd.2010.02.049 |
0.349 |
|
| 2009 |
Foss FW, Mathews TP, Kharel Y, Kennedy PC, Snyder AH, Davis MD, Lynch KR, Macdonald TL. Synthesis and biological evaluation of sphingosine kinase substrates as sphingosine-1-phosphate receptor prodrugs. Bioorganic & Medicinal Chemistry. 17: 6123-36. PMID 19632123 DOI: 10.1016/J.Bmc.2009.04.015 |
0.811 |
|
| 2009 |
Sim-Selley LJ, Goforth PB, Mba MU, Macdonald TL, Lynch KR, Milstien S, Spiegel S, Satin LS, Welch SP, Selley DE. Sphingosine-1-phosphate receptors mediate neuromodulatory functions in the CNS. Journal of Neurochemistry. 110: 1191-202. PMID 19493165 DOI: 10.1111/J.1471-4159.2009.06202.X |
0.505 |
|
| 2009 |
Tomsig JL, Snyder AH, Berdyshev EV, Skobeleva A, Mataya C, Natarajan V, Brindley DN, Lynch KR. Lipid phosphate phosphohydrolase type 1 (LPP1) degrades extracellular lysophosphatidic acid in vivo. The Biochemical Journal. 419: 611-8. PMID 19215222 DOI: 10.1042/Bj20081888 |
0.702 |
|
| 2009 |
Gaetano CG, Samadi N, Tomsig JL, Macdonald TL, Lynch KR, Brindley DN. Inhibition of autotaxin production or activity blocks lysophosphatidylcholine-induced migration of human breast cancer and melanoma cells. Molecular Carcinogenesis. 48: 801-9. PMID 19204929 DOI: 10.1002/Mc.20524 |
0.345 |
|
| 2009 |
Li MH, Sanchez T, Yamase H, Hla T, Oo ML, Pappalardo A, Lynch KR, Lin CY, Ferrer F. S1P/S1P1 signaling stimulates cell migration and invasion in Wilms tumor. Cancer Letters. 276: 171-9. PMID 19131156 DOI: 10.1016/J.Canlet.2008.11.025 |
0.409 |
|
| 2009 |
Jo SK, Bajwa A, Ye H, Vergis AL, Awad AS, Kharel Y, Lynch KR, Okusa MD. Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury. Kidney International. 75: 167-75. PMID 18971925 DOI: 10.1038/Ki.2008.400 |
0.348 |
|
| 2008 |
Li MH, Sanchez T, Pappalardo A, Lynch KR, Hla T, Ferrer F. Induction of antiproliferative connective tissue growth factor expression in Wilms' tumor cells by sphingosine-1-phosphate receptor 2. Molecular Cancer Research : McR. 6: 1649-56. PMID 18922980 DOI: 10.1158/1541-7786.Mcr-07-2048 |
0.418 |
|
| 2008 |
Panchatcharam M, Miriyala S, Yang F, Rojas M, End C, Vallant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS. Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure. Circulation Research. 103: 662-70. PMID 18703779 DOI: 10.1161/Circresaha.108.180778 |
0.393 |
|
| 2008 |
Lynch KR, Macdonald TL. Sphingosine 1-phosphate chemical biology. Biochimica Et Biophysica Acta. 1781: 508-12. PMID 18638568 DOI: 10.1016/J.Bbalip.2008.06.006 |
0.348 |
|
| 2008 |
Wamhoff BR, Lynch KR, Macdonald TL, Owens GK. Sphingosine-1-phosphate receptor subtypes differentially regulate smooth muscle cell phenotype. Arteriosclerosis, Thrombosis, and Vascular Biology. 28: 1454-61. PMID 18535287 DOI: 10.1161/Atvbaha.107.159392 |
0.47 |
|
| 2008 |
Rivera-Lopez CM, Tucker AL, Lynch KR. Lysophosphatidic acid (LPA) and angiogenesis. Angiogenesis. 11: 301-10. PMID 18504643 DOI: 10.1007/S10456-008-9113-5 |
0.75 |
|
| 2008 |
van Meeteren LA, Brinkmann V, Saulnier-Blache JS, Lynch KR, Moolenaar WH. Anticancer activity of FTY720: phosphorylated FTY720 inhibits autotaxin, a metastasis-enhancing and angiogenic lysophospholipase D. Cancer Letters. 266: 203-8. PMID 18378389 DOI: 10.1016/J.Canlet.2008.02.052 |
0.407 |
|
| 2008 |
Hughes JE, Srinivasan S, Lynch KR, Proia RL, Ferdek P, Hedrick CC. Sphingosine-1-phosphate induces an antiinflammatory phenotype in macrophages. Circulation Research. 102: 950-8. PMID 18323526 DOI: 10.1161/Circresaha.107.170779 |
0.382 |
|
| 2008 |
Jo SK, Bajwa A, Awad AS, Lynch KR, Okusa MD. Sphingosine-1-phosphate receptors: biology and therapeutic potential in kidney disease. Kidney International. 73: 1220-30. PMID 18322542 DOI: 10.1038/Ki.2008.34 |
0.45 |
|
| 2008 |
Srinivasan S, Bolick DT, Lukashev D, Lappas C, Sitkovsky M, Lynch KR, Hedrick CC. Sphingosine-1-phosphate reduces CD4+ T-cell activation in type 1 diabetes through regulation of hypoxia-inducible factor short isoform I.1 and CD69. Diabetes. 57: 484-93. PMID 18003758 DOI: 10.2337/Db07-0855 |
0.333 |
|
| 2007 |
Okusa MD, Lynch KR. Targeting sphingosine 1 phosphate receptor type 1 receptors in acute kidney injury. Drug Discovery Today. Disease Mechanisms. 4: 55-59. PMID 19448841 DOI: 10.1016/J.Ddmec.2007.07.001 |
0.468 |
|
| 2007 |
Zhu R, Snyder AH, Kharel Y, Schaffter L, Sun Q, Kennedy PC, Lynch KR, Macdonald TL. Asymmetric synthesis of conformationally constrained fingolimod analogues--discovery of an orally active sphingosine 1-phosphate receptor type-1 agonist and receptor type-3 antagonist. Journal of Medicinal Chemistry. 50: 6428-35. PMID 17994678 DOI: 10.1021/Jm7010172 |
0.812 |
|
| 2007 |
Cui P, Tomsig JL, McCalmont WF, Lee S, Becker CJ, Lynch KR, Macdonald TL. Synthesis and biological evaluation of phosphonate derivatives as autotaxin (ATX) inhibitors. Bioorganic & Medicinal Chemistry Letters. 17: 1634-40. PMID 17257836 DOI: 10.1016/J.Bmcl.2006.12.114 |
0.517 |
|
| 2007 |
Oo ML, Thangada S, Wu MT, Liu CH, Macdonald TL, Lynch KR, Lin CY, Hla T. Immunosuppressive and anti-angiogenic sphingosine 1-phosphate receptor-1 agonists induce ubiquitinylation and proteasomal degradation of the receptor. The Journal of Biological Chemistry. 282: 9082-9. PMID 17237497 DOI: 10.1074/Jbc.M610318200 |
0.525 |
|
| 2007 |
Foss FW, Snyder AH, Davis MD, Rouse M, Okusa MD, Lynch KR, Macdonald TL. Synthesis and biological evaluation of gamma-aminophosphonates as potent, subtype-selective sphingosine 1-phosphate receptor agonists and antagonists. Bioorganic & Medicinal Chemistry. 15: 663-77. PMID 17113298 DOI: 10.1016/J.Bmc.2006.10.060 |
0.764 |
|
| 2006 |
Awad AS, Ye H, Huang L, Li L, Foss FW, Macdonald TL, Lynch KR, Okusa MD. Selective sphingosine 1-phosphate 1 receptor activation reduces ischemia-reperfusion injury in mouse kidney. American Journal of Physiology. Renal Physiology. 290: F1516-24. PMID 16403835 DOI: 10.1152/Ajprenal.00311.2005 |
0.437 |
|
| 2006 |
Wamhoff BR, Lynch K, Owens GK. Differential regulation of smooth muscle cell phenotype by sphingosine-1-phosphate receptors. The Faseb Journal. 20. DOI: 10.1096/Fasebj.20.4.A699-C |
0.377 |
|
| 2005 |
Foss FW, Clemens JJ, Davis MD, Snyder AH, Zigler MA, Lynch KR, Macdonald TL. Synthesis, stability, and implications of phosphothioate agonists of sphingosine-1-phosphate receptors. Bioorganic & Medicinal Chemistry Letters. 15: 4470-4. PMID 16125386 DOI: 10.1016/J.Bmcl.2005.07.057 |
0.748 |
|
| 2005 |
Kharel Y, Lee S, Snyder AH, Sheasley-O'neill SL, Morris MA, Setiady Y, Zhu R, Zigler MA, Burcin TL, Ley K, Tung KS, Engelhard VH, Macdonald TL, Pearson-White S, Lynch KR. Sphingosine kinase 2 is required for modulation of lymphocyte traffic by FTY720. The Journal of Biological Chemistry. 280: 36865-72. PMID 16093248 DOI: 10.1074/Jbc.M506293200 |
0.739 |
|
| 2005 |
Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of 4(5)-phenylimidazole-based analogues of sphingosine-1-phosphate and FTY720: discovery of potent S1P1 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 15: 3568-72. PMID 15982878 DOI: 10.1016/J.Bmcl.2005.05.097 |
0.5 |
|
| 2005 |
Lee S, Lynch KR. Brown recluse spider (Loxosceles reclusa) venom phospholipase D (PLD) generates lysophosphatidic acid (LPA). The Biochemical Journal. 391: 317-23. PMID 15926888 DOI: 10.1042/Bj20050043 |
0.514 |
|
| 2005 |
Bolick DT, Srinivasan S, Kim KW, Hatley ME, Clemens JJ, Whetzel A, Ferger N, Macdonald TL, Davis MD, Tsao PS, Lynch KR, Hedrick CC. Sphingosine-1-phosphate prevents tumor necrosis factor-{alpha}-mediated monocyte adhesion to aortic endothelium in mice. Arteriosclerosis, Thrombosis, and Vascular Biology. 25: 976-81. PMID 15761190 DOI: 10.1161/01.Atv.0000162171.30089.F6 |
0.409 |
|
| 2005 |
Davis MD, Clemens JJ, Macdonald TL, Lynch KR. Sphingosine 1-phosphate analogs as receptor antagonists. The Journal of Biological Chemistry. 280: 9833-41. PMID 15590668 DOI: 10.1074/Jbc.M412356200 |
0.502 |
|
| 2004 |
Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of benzimidazole based analogues of sphingosine-1-phosphate: discovery of potent, subtype-selective S1P4 receptor agonists. Bioorganic & Medicinal Chemistry Letters. 14: 4903-6. PMID 15341948 DOI: 10.1016/J.Bmcl.2004.07.030 |
0.51 |
|
| 2004 |
Heasley BH, Jarosz R, Carter KM, Van SJ, Lynch KR, Macdonald TL. A novel series of 2-pyridyl-containing compounds as lysophosphatidic acid receptor antagonists: development of a nonhydrolyzable LPA3 receptor-selective antagonist. Bioorganic & Medicinal Chemistry Letters. 14: 4069-74. PMID 15225728 DOI: 10.1016/J.Bmcl.2004.05.023 |
0.479 |
|
| 2004 |
Santos WL, Heasley BH, Jarosz R, Carter KM, Lynch KR, Macdonald TL. Synthesis and biological evaluation of phosphonic and thiophosphoric acid derivatives of lysophosphatidic acid. Bioorganic & Medicinal Chemistry Letters. 14: 3473-6. PMID 15177455 DOI: 10.1016/J.Bmcl.2004.04.061 |
0.457 |
|
| 2004 |
Heasley BH, Jarosz R, Lynch KR, Macdonald TL. Initial structure-activity relationships of lysophosphatidic acid receptor antagonists: discovery of a high-affinity LPA1/LPA3 receptor antagonist. Bioorganic & Medicinal Chemistry Letters. 14: 2735-40. PMID 15125924 DOI: 10.1016/J.Bmcl.2004.03.076 |
0.495 |
|
| 2004 |
Steinke JW, Crouse CD, Bradley D, Hise K, Lynch K, Kountakis SE, Borish L. Characterization of Interleukin-4-Stimulated Nasal Polyp Fibroblasts American Journal of Respiratory Cell and Molecular Biology. 30: 212-219. PMID 12920052 DOI: 10.1165/Rcmb.2003-0071Oc |
0.352 |
|
| 2003 |
Bektas M, Barak LS, Jolly PS, Liu H, Lynch KR, Lacana E, Suhr KB, Milstien S, Spiegel S. The G protein-coupled receptor GPR4 suppresses ERK activation in a ligand-independent manner. Biochemistry. 42: 12181-91. PMID 14567679 DOI: 10.1021/Bi035051Y |
0.493 |
|
| 2003 |
Clemens JJ, Davis MD, Lynch KR, Macdonald TL. Synthesis of para-alkyl aryl amide analogues of sphingosine-1-phosphate: discovery of potent S1P receptor agonists. Bioorganic & Medicinal Chemistry Letters. 13: 3401-4. PMID 14505636 DOI: 10.1016/S0960-894X(03)00812-6 |
0.497 |
|
| 2003 |
Okusa MD, Ye H, Huang L, Sigismund L, Macdonald T, Lynch KR. Selective blockade of lysophosphatidic acid LPA3 receptors reduces murine renal ischemia-reperfusion injury. American Journal of Physiology. Renal Physiology. 285: F565-74. PMID 12770838 DOI: 10.1152/Ajprenal.00023.2003 |
0.379 |
|
| 2003 |
Hasegawa Y, Erickson JR, Goddard GJ, Yu S, Liu S, Cheng KW, Eder A, Bandoh K, Aoki J, Jarosz R, Schrier AD, Lynch KR, Mills GB, Fang X. Identification of a phosphothionate analogue of lysophosphatidic acid (LPA) as a selective agonist of the LPA3 receptor. The Journal of Biological Chemistry. 278: 11962-9. PMID 12554733 DOI: 10.1074/Jbc.M209168200 |
0.535 |
|
| 2002 |
Jarvis MF, Burgard EC, McGaraughty S, Honore P, Lynch K, Brennan TJ, Subieta A, Van Biesen T, Cartmell J, Bianchi B, Niforatos W, Kage K, Yu H, Mikusa J, Wismer CT, et al. A-317491, a novel potent and selective non-nucleotide antagonist of P2X3 and P2X2/3 receptors, reduces chronic inflammatory and neuropathic pain in the rat. Proceedings of the National Academy of Sciences of the United States of America. 99: 17179-84. PMID 12482951 DOI: 10.1073/Pnas.252537299 |
0.389 |
|
| 2002 |
Honore P, Kage K, Mikusa J, Watt AT, Johnston JF, Wyatt JR, Faltynek CR, Jarvis MF, Lynch K. Analgesic profile of intrathecal P2X(3) antisense oligonucleotide treatment in chronic inflammatory and neuropathic pain states in rats. Pain. 99: 11-9. PMID 12237180 DOI: 10.1016/S0304-3959(02)00032-5 |
0.395 |
|
| 2002 |
Brinkmann V, Lynch KR. FTY720: targeting G-protein-coupled receptors for sphingosine 1-phosphate in transplantation and autoimmunity. Current Opinion in Immunology. 14: 569-75. PMID 12183155 DOI: 10.1016/S0952-7915(02)00374-6 |
0.423 |
|
| 2002 |
Lynch KR, Macdonald TL. Structure-activity relationships of lysophosphatidic acid analogs. Biochimica Et Biophysica Acta. 1582: 289-94. PMID 12069840 DOI: 10.1016/S1388-1981(02)00183-X |
0.445 |
|
| 2002 |
Lynch KR. Lysophospholipid receptor nomenclature. Biochimica Et Biophysica Acta. 1582: 70-1. PMID 12069811 DOI: 10.1016/S1388-1981(02)00138-5 |
0.458 |
|
| 2002 |
Takafuji VA, Evans A, Lynch KR, Roche JK. PGE(2) receptors and synthesis in human gastric mucosa: perturbation in cancer. Prostaglandins, Leukotrienes, and Essential Fatty Acids. 66: 71-81. PMID 12051958 DOI: 10.1054/Plef.2001.0299 |
0.354 |
|
| 2002 |
Chun J, Goetzl EJ, Hla T, Igarashi Y, Lynch KR, Moolenaar W, Pyne S, Tigyi G. International Union of Pharmacology. XXXIV. Lysophospholipid receptor nomenclature. Pharmacological Reviews. 54: 265-9. PMID 12037142 DOI: 10.1124/Pr.54.2.265 |
0.518 |
|
| 2002 |
Brinkmann V, Davis MD, Heise CE, Albert R, Cottens S, Hof R, Bruns C, Prieschl E, Baumruker T, Hiestand P, Foster CA, Zollinger M, Lynch KR. The immune modulator FTY720 targets sphingosine 1-phosphate receptors. The Journal of Biological Chemistry. 277: 21453-7. PMID 11967257 DOI: 10.1074/Jbc.C200176200 |
0.69 |
|
| 2001 |
Heise CE, Santos WL, Schreihofer AM, Heasley BH, Mukhin YV, Macdonald TL, Lynch KR. Activity of 2-substituted lysophosphatidic acid (LPA) analogs at LPA receptors: discovery of a LPA1/LPA3 receptor antagonist. Molecular Pharmacology. 60: 1173-80. PMID 11723223 DOI: 10.1124/Mol.60.6.1173 |
0.736 |
|
| 2001 |
Lee DK, George SR, Evans JF, Lynch KR, O'Dowd BF. Orphan G protein-coupled receptors in the CNS. Current Opinion in Pharmacology. 1: 31-9. PMID 11712532 DOI: 10.1016/S1471-4892(01)00003-0 |
0.361 |
|
| 2001 |
Im DS, Clemens J, Macdonald TL, Lynch KR. Characterization of the human and mouse sphingosine 1-phosphate receptor, S1P5 (Edg-8): structure-activity relationship of sphingosine1-phosphate receptors. Biochemistry. 40: 14053-60. PMID 11705398 DOI: 10.1021/Bi011606I |
0.472 |
|
| 2001 |
Takafuji V, Lublin D, Lynch K, Roche JK. Mucosal prostanoid receptors and synthesis in familial adenomatous polyposis Histochemistry and Cell Biology. 116: 171-181. PMID 11685545 DOI: 10.1007/S004180100287 |
0.46 |
|
| 2001 |
Lee DK, Nguyen T, Lynch KR, Cheng R, Vanti WB, Arkhitko O, Lewis T, Evans JF, George SR, O'Dowd BF. Discovery and mapping of ten novel G protein-coupled receptor genes. Gene. 275: 83-91. PMID 11574155 DOI: 10.1016/S0378-1119(01)00651-5 |
0.378 |
|
| 2001 |
Im DS, Heise CE, Nguyen T, O'Dowd BF, Lynch KR. Identification of a molecular target of psychosine and its role in globoid cell formation. The Journal of Cell Biology. 153: 429-34. PMID 11309421 DOI: 10.1083/Jcb.153.2.429 |
0.705 |
|
| 2001 |
Figueroa DJ, Breyer RM, Defoe SK, Kargman S, Daugherty BL, Waldburger K, Liu Q, Clements M, Zeng Z, O'Neill GP, Jones TR, Lynch KR, Austin CP, Evans JF. Expression of the cysteinyl leukotriene 1 receptor in normal human lung and peripheral blood leukocytes. American Journal of Respiratory and Critical Care Medicine. 163: 226-33. PMID 11208650 DOI: 10.1164/ajrccm.163.1.2003101 |
0.35 |
|
| 2001 |
Nguyen T, Shapiro DA, George SR, Setola V, Lee DK, Cheng R, Rauser L, Lee SP, Lynch KR, Roth BL, O'Dowd BF. Discovery of a novel member of the histamine receptor family. Molecular Pharmacology. 59: 427-33. PMID 11179435 DOI: 10.1124/Mol.59.3.427 |
0.568 |
|
| 2001 |
Lee DK, George SR, Cheng R, Nguyen T, Liu Y, Brown M, Lynch KR, O'Dowd BF. Identification of four novel human G protein-coupled receptors expressed in the brain. Brain Research. Molecular Brain Research. 86: 13-22. PMID 11165367 DOI: 10.1016/S0169-328X(00)00242-4 |
0.4 |
|
| 2001 |
Hooks SB, Santos WL, Im DS, Heise CE, Macdonald TL, Lynch KR. Lysophosphatidic acid-induced mitogenesis is regulated by lipid phosphate phosphatases and is Edg-receptor independent. The Journal of Biological Chemistry. 276: 4611-21. PMID 11042183 DOI: 10.1074/Jbc.M007782200 |
0.816 |
|
| 2000 |
Im DS, Ungar AR, Lynch KR. Characterization of a zebrafish (Danio rerio) sphingosine 1-phosphate receptor expressed in the embryonic brain. Biochemical and Biophysical Research Communications. 279: 139-43. PMID 11112429 DOI: 10.1006/Bbrc.2000.3933 |
0.458 |
|
| 2000 |
Takafuji V, Cosme R, Lublin D, Lynch K, Roche JK. Prostanoid receptors in intestinal epithelium: Selective expression, function, and change with inflammation Prostaglandins Leukotrienes and Essential Fatty Acids. 63: 223-235. PMID 11049698 DOI: 10.1016/S0016-5085(00)85381-0 |
0.427 |
|
| 2000 |
Cosme R, Lublin D, Takafuji V, Lynch K, Roche JK. Prostanoids in human colonic mucosa: Effects of inflammation on PGE2 receptor expression Human Immunology. 61: 684-696. PMID 10880739 DOI: 10.1016/S0016-5085(00)85326-3 |
0.421 |
|
| 2000 |
Heise CE, O'Dowd BF, Figueroa DJ, Sawyer N, Nguyen T, Im DS, Stocco R, Bellefeuille JN, Abramovitz M, Cheng R, Williams DL, Zeng Z, Liu Q, Ma L, Clements MK, ... ... Lynch KR, et al. Characterization of the human cysteinyl leukotriene 2 receptor. The Journal of Biological Chemistry. 275: 30531-6. PMID 10851239 DOI: 10.1074/Jbc.M003490200 |
0.75 |
|
| 2000 |
Im DS, Heise CE, Ancellin N, O'Dowd BF, Shei GJ, Heavens RP, Rigby MR, Hla T, Mandala S, McAllister G, George SR, Lynch KR. Characterization of a novel sphingosine 1-phosphate receptor, Edg-8. The Journal of Biological Chemistry. 275: 14281-6. PMID 10799507 DOI: 10.1074/Jbc.275.19.14281 |
0.704 |
|
| 2000 |
Im DS, Heise CE, Harding MA, George SR, O'Dowd BF, Theodorescu D, Lynch KR. Molecular cloning and characterization of a lysophosphatidic acid receptor, Edg-7, expressed in prostate. Molecular Pharmacology. 57: 753-9. PMID 10727522 DOI: 10.1124/Mol.57.4.753 |
0.725 |
|
| 2000 |
Lee DK, Lynch KR, Nguyen T, Im DS, Cheng R, Saldivia VR, Liu Y, Liu IS, Heng HH, Seeman P, George SR, O'Dowd BF, Marchese A. Cloning and characterization of additional members of the G protein-coupled receptor family. Biochimica Et Biophysica Acta. 1490: 311-23. PMID 10684976 DOI: 10.1016/S0167-4781(99)00241-9 |
0.421 |
|
| 1999 |
Lynch KR, Im DS. Life on the edg. Trends in Pharmacological Sciences. 20: 473-5. PMID 10603487 DOI: 10.1016/S0165-6147(99)01401-7 |
0.353 |
|
| 1999 |
Marchese A, George SR, Kolakowski LF, Lynch KR, O'Dowd BF. Novel GPCRs and their endogenous ligands: expanding the boundaries of physiology and pharmacology. Trends in Pharmacological Sciences. 20: 370-5. PMID 10462760 DOI: 10.1016/S0165-6147(99)01366-8 |
0.43 |
|
| 1999 |
Lynch KR, O'Neill GP, Liu Q, Im DS, Sawyer N, Metters KM, Coulombe N, Abramovitz M, Figueroa DJ, Zeng Z, Connolly BM, Bai C, Austin CP, Chateauneuf A, Stocco R, et al. Characterization of the human cysteinyl leukotriene CysLT1 receptor. Nature. 399: 789-93. PMID 10391245 DOI: 10.1038/21658 |
0.74 |
|
| 1999 |
Hopper DW, Ragan SP, Hooks SB, Lynch KR, Macdonald TL. Structure--activity relationships of lysophosphatidic acid: conformationally restricted backbone mimetics. Journal of Medicinal Chemistry. 42: 963-70. PMID 10090779 DOI: 10.1021/Jm970809V |
0.739 |
|
| 1999 |
Marchese A, Sawzdargo M, Nguyen T, Cheng R, Heng HH, Nowak T, Im DS, Lynch KR, George SR, O'dowd BF. Discovery of three novel orphan G-protein-coupled receptors. Genomics. 56: 12-21. PMID 10036181 DOI: 10.1006/Geno.1998.5655 |
0.417 |
|
| 1999 |
Sawzdargo M, Nguyen T, Lee DK, Lynch KR, Cheng R, Heng HH, George SR, O'Dowd BF. Identification and cloning of three novel human G protein-coupled receptor genes GPR52, PsiGPR53 and GPR55: GPR55 is extensively expressed in human brain. Brain Research. Molecular Brain Research. 64: 193-8. PMID 9931487 DOI: 10.1016/S0169-328X(98)00277-0 |
0.392 |
|
| 1999 |
Im DS, Hooks SB, Lynch KR. Molecular pharmacology of lipid phosphoric acid receptors Proceedings of the Western Pharmacology Society. 42: 144. |
0.696 |
|
| 1998 |
Hooks SB, Ragan SP, Lynch KR. Identification of a novel human phosphatidic acid phosphatase type 2 isoform. Febs Letters. 427: 188-92. PMID 9607309 DOI: 10.1016/S0014-5793(98)00421-9 |
0.654 |
|
| 1998 |
Lee A, Wissekerke AE, Rosin DL, Lynch KR. Localization of alpha2C-adrenergic receptor immunoreactivity in catecholaminergic neurons in the rat central nervous system. Neuroscience. 84: 1085-96. PMID 9578397 DOI: 10.1016/S0306-4522(97)00578-2 |
0.571 |
|
| 1998 |
O'Dowd BF, Nguyen T, Marchese A, Cheng R, Lynch KR, Heng HH, Kolakowski LF, George SR. Discovery of three novel G-protein-coupled receptor genes. Genomics. 47: 310-3. PMID 9479505 DOI: 10.1006/Geno.1998.5095 |
0.405 |
|
| 1998 |
Hooks SB, Ragan SP, Hopper DW, Hönemann CW, Durieux ME, Macdonald TL, Lynch KR. Characterization of a receptor subtype-selective lysophosphatidic acid mimetic. Molecular Pharmacology. 53: 188-94. PMID 9463475 DOI: 10.1124/Mol.53.2.188 |
0.725 |
|
| 1998 |
Takafuji V, Lublin D, Lynch K, Roche J. Prostanoid receptors on human gastric mucosa: Localization and type Gastroenterology. 114: A686. DOI: 10.1016/S0016-5085(98)82814-X |
0.336 |
|
| 1998 |
Worledge K, Takafuji V, Lublin D, Lynch K, Roche J. Localization of prostanoid G-protein coupled receptors in human colonic mucosa Gastroenterology. 114: A433. DOI: 10.1016/S0016-5085(98)81755-1 |
0.376 |
|
| 1997 |
Lynch KR, Hopper DW, Carlisle SJ, Catalano JG, Zhang M, MacDonald TL. Structure/activity relationships in lysophosphatidic acid: the 2-hydroxyl moiety. Molecular Pharmacology. 52: 75-81. PMID 9224815 DOI: 10.1124/Mol.52.1.75 |
0.345 |
|
| 1997 |
O'Dowd BF, Nguyen T, Jung BP, Marchese A, Cheng R, Heng HH, Kolakowski LF, Lynch KR, George SR. Cloning and chromosomal mapping of four putative novel human G-protein-coupled receptor genes. Gene. 187: 75-81. PMID 9073069 DOI: 10.1016/S0378-1119(96)00722-6 |
0.337 |
|
| 1997 |
Jung BP, Nguyen T, Kolakowski LF, Lynch KR, Heng HHQ, George SR, O'Dowd BF. Discovery of a novel human G protein-coupled receptor gene (GPR25) located on chromosome 1 Biochemical and Biophysical Research Communications. 230: 69-72. PMID 9020062 DOI: 10.1006/Bbrc.1996.5828 |
0.438 |
|
| 1996 |
Kolakowski LF, Jung BP, Nguyen T, Johnson MP, Lynch KR, Cheng R, Heng HHQ, George SR, O'Dowd BF. Characterization of a human gene related to genes encoding somatostatin receptors Febs Letters. 398: 253-258. PMID 8977118 DOI: 10.1016/S0014-5793(96)01160-X |
0.383 |
|
| 1996 |
D'Angelo DD, Terasawa T, Carlisle SJ, Dorn GW, Lynch KR. Characterization of a rat kidney thromboxane A2 receptor: high affinity for the agonist ligand I-BOP. Prostaglandins. 52: 303-16. PMID 8936585 DOI: 10.1016/S0090-6980(96)00091-3 |
0.402 |
|
| 1996 |
Rosin DL, Talley EM, Lee A, Stornetta RL, Gaylinn BD, Guyenet PG, Lynch KR. Distribution of alpha 2C-adrenergic receptor-like immunoreactivity in the rat central nervous system. The Journal of Comparative Neurology. 372: 135-65. PMID 8841925 DOI: 10.1002/(Sici)1096-9861(19960812)372:1<135::Aid-Cne9>3.0.Co;2-4 |
0.46 |
|
| 1996 |
O'Dowd BF, Nguyen T, Lynch KR, Kolakowski LF, Thompson M, Cheng R, Marchese A, Ng G, Heng HH, George SR. A novel gene codes for a putative G protein-coupled receptor with an abundant expression in brain. Febs Letters. 394: 325-9. PMID 8830667 DOI: 10.1016/0014-5793(96)00901-5 |
0.421 |
|
| 1995 |
Lee A, Talley E, Rosin DL, Lynch KR. Characterization of alpha 2A-adrenergic receptors in GT1 neurosecretory cells. Neuroendocrinology. 62: 215-25. PMID 8538858 DOI: 10.1159/000127007 |
0.47 |
|
| 1995 |
Stornetta RL, Huangfu D, Rosin DL, Lynch KR, Guyenet PG. Alpha-2 adrenergic receptors. Immunohistochemical localization and role in mediating inhibition of adrenergic RVLM presympathetic neurons by catecholamines and clonidine. Annals of the New York Academy of Sciences. 763: 541-51. PMID 7677372 DOI: 10.1111/J.1749-6632.1995.Tb32448.X |
0.358 |
|
| 1994 |
Durieux ME, Salafranca MN, Lynch KR. Trypsin induces Ca2+-activated Cl- currents in X. laevis oocytes Febs Letters. 337: 235-238. PMID 8293805 DOI: 10.1016/0014-5793(94)80198-3 |
0.35 |
|
| 1994 |
Harrison JK, Barber CM, Lynch KR. cDNA cloning of a G-protein-coupled receptor expressed in rat spinal cord and brain related to chemokine receptors Neuroscience Letters. 169: 85-89. PMID 8047298 DOI: 10.1016/0304-3940(94)90362-X |
0.372 |
|
| 1994 |
Okusa MD, Lynch KR, Rosin DL, Huang L, Wei YY. Apical membrane and intracellular distribution of endogenous α2A-adrenergic receptors in MDCK cells American Journal of Physiology - Renal Fluid and Electrolyte Physiology. 267: F347-F353. PMID 7916533 DOI: 10.1152/Ajprenal.1994.267.3.F347 |
0.333 |
|
| 1994 |
Lynch KR, Harrison JK, Pearson WR. Classification of Adrenergic Receptor Subtypes: Molecular Biologic Approaches Neuroprotocols. 4: 14-19. DOI: 10.1006/Ncmn.1994.1003 |
0.429 |
|
| 1993 |
Wu J, Harrison JK, Dent P, Lynch KR, Weber MJ, Sturgill TW. Identification and Characterization of a New Mammalian Mitogen-Activated Protein Kinase Kinase, MKK2 Molecular and Cellular Biology. 13: 4539-4548. PMID 8393135 DOI: 10.1128/Mcb.13.8.4539 |
0.341 |
|
| 1993 |
Harrison JK, Barber CM, Lynch KR. Molecular cloning of a novel rat G-protein-coupled receptor gene expressed prominently in lung, adrenal, and liver Febs Letters. 318: 17-22. PMID 8382168 DOI: 10.1016/0014-5793(93)81318-T |
0.353 |
|
| 1993 |
Wu J, Harrison JK, Vincent LA, Haystead C, Haystead TAJ, Michel H, Hunt DF, Lynch KR, Sturgill TW. Molecular structure of a protein-tyrosine/threonine kinase activating p42 mitogen-activated protein (MAP) kinase: MAP kinase kinase Proceedings of the National Academy of Sciences of the United States of America. 90: 173-177. PMID 8380494 DOI: 10.1073/Pnas.90.1.173 |
0.313 |
|
| 1993 |
Durieux ME, Lynch KR. Signalling properties of lysophosphatidic acid Trends in Pharmacological Sciences. 14: 249-254. PMID 8372406 DOI: 10.1016/0165-6147(93)90021-B |
0.392 |
|
| 1993 |
Rosin DL, Zeng D, Stornetta RL, Norton FR, Riley T, Okusa MD, Guyenet PG, Lynch KR. Immunohistochemical localization of alpha 2A-adrenergic receptors in catecholaminergic and other brainstem neurons in the rat. Neuroscience. 56: 139-55. PMID 7901804 DOI: 10.1016/0306-4522(93)90569-2 |
0.376 |
|
| 1993 |
Durieux ME, Carlisle SJ, Salafranca MN, Lynch KR. Responses to sphingosine-1-phosphate in X. laevis oocytes: Similarities with lysophosphatidic acid signaling American Journal of Physiology - Cell Physiology. 264: C1360-C1364. PMID 7684565 DOI: 10.1152/Ajpcell.1993.264.5.C1360 |
0.382 |
|
| 1993 |
Gaylinn BD, Harrison JK, Zysk JR, Lyons CE, Lynch KR, Thorner MO. Molecular cloning and expression of a human anterior pituitary receptor for growth hormone-releasing hormone Molecular Endocrinology. 7: 77-84. PMID 7680413 DOI: 10.1210/Mend.7.1.7680413 |
0.427 |
|
| 1992 |
Tucker AL, Linden J, Robeva AS, D'Angelo DD, Lynch KR. Cloning and expression of a bovine adenosine A1 receptor cDNA. Febs Letters. 297: 107-11. PMID 1551415 DOI: 10.1016/0014-5793(92)80338-H |
0.441 |
|
| 1992 |
Durieux ME, Salafranca MN, Lynch KR, Moorman JR. Lysophosphatidic acid induces a pertussis toxin-sensitive Ca(2+)-activated Cl- current in Xenopus laevis oocytes. The American Journal of Physiology. 263: C896-900. PMID 1415674 DOI: 10.1152/Ajpcell.1992.263.4.C896 |
0.335 |
|
| 1991 |
Harrison JK, Pearson WR, Lynch KR. Molecular characterization of α1- and α2-adrenoceptors Trends in Pharmacological Sciences. 12: 62-67. PMID 2024290 DOI: 10.1016/0165-6147(91)90499-I |
0.405 |
|
| 1991 |
Linden J, Tucker AL, Lynch KR. Molecular cloning of adenosine A1 and A2 receptors Trends in Pharmacological Sciences. 12: 326-328. PMID 1949201 DOI: 10.1016/0165-6147(91)90589-K |
0.305 |
|
| 1991 |
Harrison JK, D'Angelo DD, Zeng DW, Lynch KR. Pharmacological characterization of rat alpha 2-adrenergic receptors. Molecular Pharmacology. 40: 407-12. PMID 1654514 |
0.314 |
|
| 1991 |
Zeng D, Lynch KR. Distribution of α2-adrenergic receptor mRNAs in the rat CNS Molecular Brain Research. 10: 219-225. PMID 1653390 DOI: 10.1016/0169-328X(91)90064-5 |
0.308 |
|
| 1990 |
Zeng DW, Harrison JK, D'Angelo DD, Barber CM, Tucker AL, Lu ZH, Lynch KR. Molecular characterization of a rat alpha 2B-adrenergic receptor. Proceedings of the National Academy of Sciences of the United States of America. 87: 3102-6. PMID 2158103 DOI: 10.1073/Pnas.87.8.3102 |
0.363 |
|
| 1990 |
Ross PC, Figler RA, Corjay MH, Barber CM, Adam N, Harcus DR, Lynch KR. RTA, a candidate G protein-coupled receptor: Cloning, sequencing, and tissue distribution Proceedings of the National Academy of Sciences of the United States of America. 87: 3052-3056. PMID 2109324 DOI: 10.1073/Pnas.87.8.3052 |
0.383 |
|
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