Jerold Chun - Publications

Affiliations: 
1991-2001 Pharmacology & Neuroscience University of California, San Diego, La Jolla, CA 
 2003-2016 Molecular Biology, Molecular and Cellular Neuroscience Scripps Research Institute, La Jolla, La Jolla, CA, United States 
 2016- Sanford Burnham Prebys Medical Discovery Institute 
Area:
Brain Genomic Mosaicism and Gene Recombination; LPA, S1P, Lysophospholipid Signaling
Website:
http://labs.sbpdiscovery.org/centerandlabs/neuroagingstem/chunlab/Pages/home.aspx

201 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Gonzalez Gil I, Zian D, Vázquez-Villa H, Hernandez-Torres G, Martinez RF, Khiar-Fernandez N, Rivera R, Kihara Y, Devesa I, Mathivanan S, Rosell Del Valle C, Zambrana-Infantes E, Puigdomenech M, Cincilla G, Sanchez-Martinez M, ... ... Chun J, et al. A novel agonist of the type 1 lysophosphatidic acid receptor (LPA1), UCM-05194, shows efficacy in neuropathic pain amelioration. Journal of Medicinal Chemistry. PMID 31790581 DOI: 10.1021/acs.jmedchem.9b01287  1
2019 Lummis NC, Sánchez-Pavón P, Kennedy G, Frantz AJ, Kihara Y, Blaho VA, Chun J. LPA overactivation induces neonatal posthemorrhagic hydrocephalus through ependymal loss and ciliary dysfunction. Science Advances. 5: eaax2011. PMID 31633020 DOI: 10.1126/sciadv.aax2011  1
2019 González de San Román E, Manuel I, Ledent C, Chun J, Rodríguez de Fonseca F, Estivill-Torrús G, Santín LJ, Rodríguez Puertas R. CB and LPA Receptors Relationship in the Mouse Central Nervous System. Frontiers in Molecular Neuroscience. 12: 223. PMID 31607860 DOI: 10.3389/fnmol.2019.00223  1
2019 Miyabe C, Miyabe Y, Nagai J, Miura NN, Ohno N, Chun J, Tsuboi R, Ueda H, Miyasaka M, Miyasaka N, Nanki T. Abrogation of lysophosphatidic acid receptor 1 ameliorates murine vasculitis. Arthritis Research & Therapy. 21: 191. PMID 31429784 DOI: 10.1186/s13075-019-1973-0  1
2019 Tabbai S, Moreno-Fernández RD, Zambrana-Infantes E, Nieto-Quero A, Chun J, García-Fernández M, Estivill-Torrús G, Rodríguez de Fonseca F, Santín LJ, Oliveira TG, Pérez-Martín M, Pedraza C. Effects of the LPA Receptor Deficiency and Stress on the Hippocampal LPA Species in Mice. Frontiers in Molecular Neuroscience. 12: 146. PMID 31244601 DOI: 10.3389/fnmol.2019.00146  1
2019 Lee MH, Chun J. Mosaic Gene Recombination in Alzheimer's Disease-What's Next? Journal of Experimental Neuroscience. 13: 1179069519849669. PMID 31205422 DOI: 10.1177/1179069519849669  0.92
2019 Suckau O, Gross I, Schrötter S, Yang F, Luo J, Wree A, Chun J, Baska D, Baumgart J, Kano K, Aoki J, Bräuer AU. LPA , LPA , LPA , and LPA receptor expression during mouse brain development. Developmental Dynamics : An Official Publication of the American Association of Anatomists. PMID 30847983 DOI: 10.1002/dvdy.23  1
2019 Kano K, Matsumoto H, Inoue A, Yukiura H, Kanai M, Chun J, Ishii S, Shimizu T, Aoki J. Molecular mechanism of lysophosphatidic acid-induced hypertensive response. Scientific Reports. 9: 2662. PMID 30804442 DOI: 10.1038/s41598-019-39041-4  1
2019 Lee MH, Siddoway B, Kaeser GE, Segota I, Rivera R, Romanow WJ, Liu CS, Park C, Kennedy G, Long T, Chun J. Publisher Correction: Somatic APP gene recombination in Alzheimer's disease and normal neurons. Nature. PMID 30670873 DOI: 10.1038/s41586-019-0905-0  1
2019 Chun J, Kihara Y, Jonnalagadda D, Blaho VA. Fingolimod: Lessons Learned and New Opportunities for Treating Multiple Sclerosis and Other Disorders. Annual Review of Pharmacology and Toxicology. 59: 149-170. PMID 30625282 DOI: 10.1146/annurev-pharmtox-010818-021358  1
2019 Kim NH, Sadra A, Park HY, Oh SM, Chun J, Yoon JK, Huh SO. HeLa E-Box Binding Protein, HEB, Inhibits Promoter Activity of the Lysophosphatidic Acid Receptor Gene Lpar1 in Neocortical Neuroblast Cells. Molecules and Cells. PMID 30622227 DOI: 10.14348/molcells.2018.0399  1
2018 López-Serrano C, Santos-Nogueira E, Francos-Quijorna I, Coll-Miró M, Chun J, López-Vales R. Lysophosphatidic acid receptor type 2 activation contributes to secondary damage after spinal cord injury in mice. Brain, Behavior, and Immunity. PMID 30550929 DOI: 10.1016/j.bbi.2018.12.007  1
2018 Lee MH, Siddoway B, Kaeser GE, Segota I, Rivera R, Romanow WJ, Liu CS, Park C, Kennedy G, Long T, Chun J. Somatic APP gene recombination in Alzheimer's disease and normal neurons. Nature. PMID 30464338 DOI: 10.1038/s41586-018-0718-6  1
2018 Mizuno H, Kihara Y, Kussrow A, Chen A, Ray M, Rivera R, Bornhop D, Chun J. Lysophospholipid G protein-coupled receptor binding parameters as determined by backscattering interferometry (BSI). Journal of Lipid Research. PMID 30463988 DOI: 10.1194/jlr.D089938  1
2018 Blaho VA, Chun J. 'Crystal' Clear? Lysophospholipid Receptor Structure Insights and Controversies. Trends in Pharmacological Sciences. 39: 953-966. PMID 30343728 DOI: 10.1016/j.tips.2018.08.006  0.68
2018 Srikanth M, Chew WS, Hind T, Lim SM, Hay NWJ, Lee JHM, Rivera R, Chun J, Ong WY, Herr DR. Lysophosphatidic acid and its receptor LPA mediate carrageenan induced inflammatory pain in mice. European Journal of Pharmacology. PMID 30321532 DOI: 10.1016/j.ejphar.2018.10.005  1
2018 Rohrback S, April C, Kaper F, Rivera RR, Liu CS, Siddoway B, Chun J. Submegabase copy number variations arise during cerebral cortical neurogenesis as revealed by single-cell whole-genome sequencing. Proceedings of the National Academy of Sciences of the United States of America. PMID 30262650 DOI: 10.1073/pnas.1812702115  1
2018 Groves A, Kihara Y, Jonnalagadda D, Rivera R, Kennedy G, Mayford M, Chun J. A Functionally Defined Astrocyte Population Identified by c-Fos Activation in a Mouse Model of Multiple Sclerosis Modulated by S1P Signaling: Immediate-Early Astrocytes (). Eneuro. 5. PMID 30255127 DOI: 10.1523/ENEURO.0239-18.2018  1
2018 Moreno-Fernández RD, Nieto-Quero A, Gómez-Salas FJ, Chun J, Estivill-Torrús G, Rodríguez de Fonseca F, Santín LJ, Pérez-Martín M, Pedraza C. Effects of genetic deletion versus pharmacological blockade of the LPA receptor on depression-like behaviour and related brain functional activity. Disease Models & Mechanisms. PMID 30061118 DOI: 10.1242/dmm.035519  1
2018 Rohrback S, Siddoway B, Liu CS, Chun J. Genomic mosaicism in the developing and adult brain. Developmental Neurobiology. PMID 30027562 DOI: 10.1002/dneu.22626  1
2017 Lake BB, Chen S, Sos BC, Fan J, Kaeser GE, Yung YC, Duong TE, Gao D, Chun J, Kharchenko PV, Zhang K. Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain. Nature Biotechnology. PMID 29227469 DOI: 10.1038/nbt.4038  1
2017 Lake BB, Codeluppi S, Yung YC, Gao D, Chun J, Kharchenko PV, Linnarsson S, Zhang K. A comparative strategy for single-nucleus and single-cell transcriptomes confirms accuracy in predicted cell-type expression from nuclear RNA. Scientific Reports. 7: 6031. PMID 28729663 DOI: 10.1038/s41598-017-04426-w  1
2017 An D, Hao F, Zhang F, Kong W, Chun J, Xu X, Cui MZ. CD14 Is a Key Mediator of Both Lysophosphatidic Acid and Lipopolysaccharide Induction of Foam Cell Formation. The Journal of Biological Chemistry. PMID 28705936 DOI: 10.1074/jbc.M117.781807  1
2017 Cai L, Fan G, Wang F, Liu S, Li T, Cong X, Chun J, Chen X. Protective Role for LPA3 in Cardiac Hypertrophy Induced by Myocardial Infarction but Not by Isoproterenol. Frontiers in Physiology. 8: 356. PMID 28611684 DOI: 10.3389/fphys.2017.00356  1
2017 Aikawa S, Kano K, Inoue A, Wang J, Saigusa D, Nagamatsu T, Hirota Y, Fujii T, Tsuchiya S, Taketomi Y, Sugimoto Y, Murakami M, Arita M, Kurano M, Ikeda H, ... ... Chun J, et al. Autotaxin-lysophosphatidic acid-LPA3 signaling at the embryo-epithelial boundary controls decidualization pathways. The Embo Journal. PMID 28588064 DOI: 10.15252/embj.201696290  1
2017 Dusaban SS, Chun J, Rosen H, Purcell NH, Brown JH. Sphingosine 1-phosphate receptor 3 and RhoA signaling mediate inflammatory gene expression in astrocytes. Journal of Neuroinflammation. 14: 111. PMID 28577576 DOI: 10.1186/s12974-017-0882-x  1
2017 Dancs PT, Ruisanchez É, Balogh A, Panta CR, Miklós Z, Nüsing RM, Aoki J, Chun J, Offermanns S, Tigyi G, Benyó Z. LPA1 receptor-mediated thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle contraction. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 28069828 DOI: 10.1096/fj.201600735R  1
2016 Yung BS, Brand CS, Xiang SY, Gray CB, Means CK, Rosen H, Chun J, Purcell N, Brown JH, Miyamoto S. Selective coupling of the S1P3 receptor subtype to S1P-mediated RhoA activation and cardioprotection. Journal of Molecular and Cellular Cardiology. PMID 28017639 DOI: 10.1016/j.yjmcc.2016.12.008  1
2016 Sakai N, Chun J, Duffield JS, Lagares D, Wada T, Luster AD, Tager AM. Lysophosphatidic acid signaling through its receptor initiates profibrotic epithelial cell fibroblast communication mediated by epithelial cell derived connective tissue growth factor. Kidney International. PMID 27927603 DOI: 10.1016/j.kint.2016.09.030  1
2016 Vogt J, Kirischuk S, Unichenko P, Schlüter L, Pelosi A, Endle H, Yang JW, Schmarowski N, Cheng J, Thalman C, Strauss U, Prokudin A, Bharati BS, Aoki J, Chun J, et al. Synaptic Phospholipid Signaling Modulates Axon Outgrowth via Glutamate-dependent Ca2+-mediated Molecular Pathways. Cerebral Cortex (New York, N.Y. : 1991). PMID 27909001 DOI: 10.1093/cercor/bhw370  1
2016 Fang V, Chaluvadi VS, Ramos-Perez WD, Mendoza A, Baeyens A, Rivera R, Chun J, Cammer M, Schwab SR. Gradients of the signaling lipid S1P in lymph nodes position natural killer cells and regulate their interferon-γ response. Nature Immunology. PMID 27841869 DOI: 10.1038/ni.3619  1
2016 Gazit SL, Mariko B, Thérond P, Decouture B, Xiong Y, Couty L, Bonnin P, Baudrie V, Le Gall SM, Dizier B, Zoghdani N, Ransinan J, Hamilton JR, Gaussem P, Tharaux PL, ... Chun J, et al. Platelet and Erythrocyte Sources of S1P Are Redundant for Vascular Development and Homeostasis, but both Rendered Essential After Plasma S1P Depletion in Anaphylactic Shock. Circulation Research. PMID 27582371 DOI: 10.1161/CIRCRESAHA.116.308929  1
2016 Lai MK, Chew WS, Torta F, Rao A, Harris GL, Chun J, Herr DR. Biological Effects of Naturally Occurring Sphingolipids, Uncommon Variants, and Their Analogs. Neuromolecular Medicine. PMID 27393119 DOI: 10.1007/s12017-016-8424-8  1
2016 Lake BB, Ai R, Kaeser GE, Salathia NS, Yung YC, Liu R, Wildberg A, Gao D, Fung HL, Chen S, Vijayaraghavan R, Wong J, Chen A, Sheng X, Kaper F, ... ... Chun J, et al. Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain. Science (New York, N.Y.). 352: 1586-90. PMID 27339989 DOI: 10.1126/science.aaf1204  1
2016 Clay H, Wilsbacher LD, Wilson SJ, Duong DN, McDonald M, Lam I, Park KE, Chun J, Coughlin SR. Sphingosine 1-phosphate receptor-1 in cardiomyocytes is required for normal cardiac development. Developmental Biology. PMID 27333774 DOI: 10.1016/j.ydbio.2016.06.024  0.32
2016 Keul P, van Borren MM, Ghanem A, Müller FU, Baartscheer A, Verkerk AO, Stümpel F, Schulte JS, Hamdani N, Linke WA, van Loenen P, Matus M, Schmitz W, Stypmann J, Tiemann K, ... ... Chun J, et al. Sphingosine-1-Phosphate Receptor 1 Regulates Cardiac Function by Modulating Ca2+ Sensitivity and Na+/H+ Exchange and Mediates Protection by Ischemic Preconditioning. Journal of the American Heart Association. 5. PMID 27207969 DOI: 10.1161/JAHA.116.003393  1
2016 Alfonzo-Méndez MA, Castillo-Badillo JA, Romero-Ávila MT, Rivera R, Chun J, García-Sáinz JA. Carboxyl terminus-truncated α1D-adrenoceptors inhibit the ERK pathway. Naunyn-Schmiedeberg's Archives of Pharmacology. PMID 27146292 DOI: 10.1007/s00210-016-1254-2  1
2016 Funke M, Knudsen L, Lagares D, Ebener S, Probst CK, Fontaine BA, Franklin A, Kellner M, Kühnel M, Matthieu S, Grothausmann R, Chun J, Roberts JD, Ochs M, Tager AM. LPA Signaling Through the LPA1 Receptor is Required for Alveolarization. American Journal of Respiratory Cell and Molecular Biology. PMID 27082727 DOI: 10.1165/rcmb.2015-0152OC  1
2016 Herr DR, Reolo MJ, Peh YX, Wang W, Lee CW, Rivera R, Paterson IC, Chun J. Sphingosine 1-phosphate receptor 2 (S1P2) attenuates reactive oxygen species formation and inhibits cell death: implications for otoprotective therapy. Scientific Reports. 6: 24541. PMID 27080739 DOI: 10.1038/srep24541  1
2016 Nishioka T, Arima N, Kano K, Hama K, Itai E, Yukiura H, Kise R, Inoue A, Kim SH, Solnica-Krezel L, Moolenaar WH, Chun J, Aoki J. ATX-LPA1 axis contributes to proliferation of chondrocytes by regulating fibronectin assembly leading to proper cartilage formation. Scientific Reports. 6: 23433. PMID 27005960 DOI: 10.1038/srep23433  1
2016 Kitada Y, Kajita K, Taguchi K, Mori I, Yamauchi M, Ikeda T, Kawashima M, Asano M, Kajita T, Ishizuka T, Banno Y, Kojima I, Chun J, Kamata S, Ishii I, et al. Blockade of Sphingosine 1-Phosphate Receptor 2 Signaling Attenuates High-Fat Diet-Induced Adipocyte Hypertrophy and Systemic Glucose Intolerance in Mice. Endocrinology. en20151768. PMID 26943364 DOI: 10.1210/en.2015-1768  1
2016 Fan J, Salathia N, Liu R, Kaeser GE, Yung YC, Herman JL, Kaper F, Fan JB, Zhang K, Chun J, Kharchenko PV. Characterizing transcriptional heterogeneity through pathway and gene set overdispersion analysis. Nature Methods. PMID 26780092 DOI: 10.1038/nmeth.3734  1
2015 Moon E, Han JE, Jeon S, Ryu JH, Choi JW, Chun J. Exogenous S1P Exposure Potentiates Ischemic Stroke Damage That Is Reduced Possibly by Inhibiting S1P Receptor Signaling. Mediators of Inflammation. 2015: 492659. PMID 26576074 DOI: 10.1155/2015/492659  1
2015 Kihara Y, Groves A, Rivera RR, Chun J. Dimethyl fumarate inhibits integrin α4 expression in multiple sclerosis models. Annals of Clinical and Translational Neurology. 2: 978-83. PMID 26478898 DOI: 10.1002/acn3.251  1
2015 Santos-Nogueira E, López-Serrano C, Hernández J, Lago N, Astudillo AM, Balsinde J, Estivill-Torrús G, de Fonseca FR, Chun J, López-Vales R. Activation of Lysophosphatidic Acid Receptor Type 1 Contributes to Pathophysiology of Spinal Cord Injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 10224-35. PMID 26180199 DOI: 10.1523/JNEUROSCI.4703-14.2015  1
2015 Xu K, Ma L, Li Y, Wang F, Zheng GY, Sun Z, Jiang F, Chen Y, Liu H, Dang A, Chen X, Chun J, Tian XL. Genetic and Functional Evidence Supports LPAR1 as a Susceptibility Gene for Hypertension. Hypertension. PMID 26123684 DOI: 10.1161/HYPERTENSIONAHA.115.05515  1
2015 Chrencik JE, Roth CB, Terakado M, Kurata H, Omi R, Kihara Y, Warshaviak D, Nakade S, Asmar-Rovira G, Mileni M, Mizuno H, Griffith MT, Rodgers C, Han GW, Velasquez J, ... Chun J, et al. Crystal Structure of Antagonist Bound Human Lysophosphatidic Acid Receptor 1. Cell. 161: 1633-43. PMID 26091040 DOI: 10.1016/j.cell.2015.06.002  1
2015 González de San Román E, Manuel I, Giralt MT, Chun J, Estivill-Torrús G, Rodríguez de Fonseca F, Santín LJ, Ferrer I, Rodríguez-Puertas R. Anatomical location of LPA1 activation and LPA phospholipid precursors in rodent and human brain. Journal of Neurochemistry. 134: 471-85. PMID 25857358 DOI: 10.1111/jnc.13112  1
2015 Sheng X, Yung YC, Chen A, Chun J. Lysophosphatidic acid signalling in development. Development (Cambridge, England). 142: 1390-5. PMID 25852197 DOI: 10.1242/dev.121723  1
2015 Yung YC, Stoddard NC, Mirendil H, Chun J. Lysophosphatidic Acid signaling in the nervous system. Neuron. 85: 669-82. PMID 25695267 DOI: 10.1016/j.neuron.2015.01.009  1
2015 Bushman DM, Kaeser GE, Siddoway B, Westra JW, Rivera RR, Rehen SK, Yung YC, Chun J. Genomic mosaicism with increased amyloid precursor protein (APP) gene copy number in single neurons from sporadic Alzheimer's disease brains. Elife. 4. PMID 25650802 DOI: 10.7554/eLife.05116  1
2015 Stoddard NC, Chun J. Promising pharmacological directions in the world of lysophosphatidic Acid signaling. Biomolecules & Therapeutics. 23: 1-11. PMID 25593637 DOI: 10.4062/biomolther.2014.109  1
2015 Kihara Y, Mizuno H, Chun J. Lysophospholipid receptors in drug discovery. Experimental Cell Research. 333: 171-7. PMID 25499971 DOI: 10.1016/j.yexcr.2014.11.020  1
2014 García-Díaz B, Riquelme R, Varela-Nieto I, Jiménez AJ, de Diego I, Gómez-Conde AL, Matas-Rico E, Aguirre JA, Chun J, Pedraza C, Santín LJ, Fernández O, Rodríguez de Fonseca F, Estivill-Torrús G. Loss of lysophosphatidic acid receptor LPA1 alters oligodendrocyte differentiation and myelination in the mouse cerebral cortex. Brain Structure & Function. PMID 25226845 DOI: 10.1007/s00429-014-0885-7  1
2014 Chun J. An introduction to the Journal of Lipid Research Thematic Series on lysophospholipids. Journal of Lipid Research. 55: 798. PMID 24652606 DOI: 10.1194/jlr.E049403  1
2014 Yung YC, Stoddard NC, Chun J. LPA receptor signaling: pharmacology, physiology, and pathophysiology. Journal of Lipid Research. 55: 1192-1214. PMID 24643338 DOI: 10.1194/jlr.R046458  1
2014 Kihara Y, Maceyka M, Spiegel S, Chun J. Lysophospholipid receptor nomenclature review: IUPHAR Review 8. British Journal of Pharmacology. 171: 3575-94. PMID 24602016 DOI: 10.1111/bph.12678  1
2014 David M, Machuca-Gayet I, Kikuta J, Ottewell P, Mima F, Leblanc R, Bonnelye E, Ribeiro J, Holen I, Lopez Vales R, Jurdic P, Chun J, Clézardin P, Ishii M, Peyruchaud O. Lysophosphatidic acid receptor type 1 (LPA1) plays a functional role in osteoclast differentiation and bone resorption activity. The Journal of Biological Chemistry. 289: 6551-64. PMID 24429286 DOI: 10.1074/jbc.M113.533232  1
2014 Wu DD, Zhang F, Hao F, Chun J, Xu X, Cui MZ. Matricellular protein Cyr61 bridges lysophosphatidic acid and integrin pathways leading to cell migration. The Journal of Biological Chemistry. 289: 5774-83. PMID 24371135 DOI: 10.1074/jbc.M113.533042  1
2013 Gole J, Gore A, Richards A, Chiu YJ, Fung HL, Bushman D, Chiang HI, Chun J, Lo YH, Zhang K. Massively parallel polymerase cloning and genome sequencing of single cells using nanoliter microwells. Nature Biotechnology. 31: 1126-32. PMID 24213699 DOI: 10.1038/nbt.2720  1
2013 Anliker B, Choi JW, Lin ME, Gardell SE, Rivera RR, Kennedy G, Chun J. Lysophosphatidic acid (LPA) and its receptor, LPA1 , influence embryonic schwann cell migration, myelination, and cell-to-axon segregation. Glia. 61: 2009-22. PMID 24115248 DOI: 10.1002/glia.22572  1
2013 Castilla-Ortega E, Rosell-Valle C, Blanco E, Pedraza C, Chun J, Rodríguez de Fonseca F, Estivill-Torrús G, Santín LJ. Reduced wheel running and blunted effects of voluntary exercise in LPA1-null mice: the importance of assessing the amount of running in transgenic mice studies. Neuroscience Research. 77: 170-9. PMID 24055600 DOI: 10.1016/j.neures.2013.09.004  1
2013 Park GY, Lee YG, Berdyshev E, Nyenhuis S, Du J, Fu P, Gorshkova IA, Li Y, Chung S, Karpurapu M, Deng J, Ranjan R, Xiao L, Jaffe HA, Corbridge SJ, ... ... Chun J, et al. Autotaxin production of lysophosphatidic acid mediates allergic asthmatic inflammation. American Journal of Respiratory and Critical Care Medicine. 188: 928-40. PMID 24050723 DOI: 10.1164/rccm.201306-1014OC  1
2013 Herr DR, Lee CW, Wang W, Ware A, Rivera R, Chun J. Sphingosine 1-phosphate receptors are essential mediators of eyelid closure during embryonic development. The Journal of Biological Chemistry. 288: 29882-9. PMID 24003216 DOI: 10.1074/jbc.M113.510099  1
2013 Huang LS, Fu P, Patel P, Harijith A, Sun T, Zhao Y, Garcia JG, Chun J, Natarajan V. Lysophosphatidic acid receptor-2 deficiency confers protection against bleomycin-induced lung injury and fibrosis in mice. American Journal of Respiratory Cell and Molecular Biology. 49: 912-22. PMID 23808384 DOI: 10.1165/rcmb.2013-0070OC  1
2013 Ma L, Nagai J, Chun J, Ueda H. An LPA species (18:1 LPA) plays key roles in the self-amplification of spinal LPA production in the peripheral neuropathic pain model. Molecular Pain. 9: 29. PMID 23773289 DOI: 10.1186/1744-8069-9-29  1
2013 Miyabe Y, Miyabe C, Iwai Y, Takayasu A, Fukuda S, Yokoyama W, Nagai J, Jona M, Tokuhara Y, Ohkawa R, Albers HM, Ovaa H, Aoki J, Chun J, Yatomi Y, et al. Necessity of lysophosphatidic acid receptor 1 for development of arthritis. Arthritis and Rheumatism. 65: 2037-47. PMID 23666827 DOI: 10.1002/art.37991  1
2013 Groves A, Kihara Y, Chun J. Fingolimod: direct CNS effects of sphingosine 1-phosphate (S1P) receptor modulation and implications in multiple sclerosis therapy. Journal of the Neurological Sciences. 328: 9-18. PMID 23518370 DOI: 10.1016/j.jns.2013.02.011  1
2013 Lee SJ, Leoni G, Neumann PA, Chun J, Nusrat A, Yun CC. Distinct phospholipase C-β isozymes mediate lysophosphatidic acid receptor 1 effects on intestinal epithelial homeostasis and wound closure. Molecular and Cellular Biology. 33: 2016-28. PMID 23478264 DOI: 10.1128/MCB.00038-13  1
2013 Bushman DM, Chun J. The genomically mosaic brain: aneuploidy and more in neural diversity and disease. Seminars in Cell & Developmental Biology. 24: 357-69. PMID 23466288 DOI: 10.1016/j.semcdb.2013.02.003  1
2013 Sakai N, Chun J, Duffield JS, Wada T, Luster AD, Tager AM. LPA1-induced cytoskeleton reorganization drives fibrosis through CTGF-dependent fibroblast proliferation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1830-46. PMID 23322166 DOI: 10.1096/fj.12-219378  1
2013 Choi JW, Chun J. Lysophospholipids and their receptors in the central nervous system. Biochimica Et Biophysica Acta. 1831: 20-32. PMID 22884303 DOI: 10.1016/j.bbalip.2012.07.015  1
2012 Peterson SE, Yang AH, Bushman DM, Westra JW, Yung YC, Barral S, Mutoh T, Rehen SK, Chun J. Aneuploid cells are differentially susceptible to caspase-mediated death during embryonic cerebral cortical development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 16213-22. PMID 23152605 DOI: 10.1523/JNEUROSCI.3706-12.2012  1
2012 García-Fernández M, Castilla-Ortega E, Pedraza C, Blanco E, Hurtado-Guerrero I, Barbancho MA, Chun J, Rodríguez-de-Fonseca F, Estivill-Torrús G, Santín Núñez LJ. Chronic immobilization in the malpar1 knockout mice increases oxidative stress in the hippocampus. The International Journal of Neuroscience. 122: 583-9. PMID 22591409 DOI: 10.3109/00207454.2012.693998  1
2012 Castilla-Ortega E, Pedraza C, Chun J, de Fonseca FR, Estivill-Torrús G, Santín LJ. Hippocampal c-Fos activation in normal and LPA₁-null mice after two object recognition tasks with different memory demands. Behavioural Brain Research. 232: 400-5. PMID 22537775 DOI: 10.1016/j.bbr.2012.04.018  1
2012 Lin ME, Rivera RR, Chun J. Targeted deletion of LPA5 identifies novel roles for lysophosphatidic acid signaling in development of neuropathic pain. The Journal of Biological Chemistry. 287: 17608-17. PMID 22461625 DOI: 10.1074/jbc.M111.330183  1
2012 Ye X, Diao H, Chun J. 11-deoxy prostaglandin F(2α), a thromboxane A2 receptor agonist, partially alleviates embryo crowding in Lpar3((-/-)) females. Fertility and Sterility. 97: 757-63. PMID 22222195 DOI: 10.1016/j.fertnstert.2011.12.004  1
2012 Funke M, Zhao Z, Xu Y, Chun J, Tager AM. The lysophosphatidic acid receptor LPA1 promotes epithelial cell apoptosis after lung injury. American Journal of Respiratory Cell and Molecular Biology. 46: 355-64. PMID 22021336 DOI: 10.1165/rcmb.2010-0155OC  1
2012 Castillo-Badillo JA, Molina-Muñoz T, Romero-Ávila MT, Vázquez-Macías A, Rivera R, Chun J, García-Sáinz JA. Sphingosine 1-phosphate-mediated α1B-adrenoceptor desensitization and phosphorylation. Direct and paracrine/autocrine actions. Biochimica Et Biophysica Acta. 1823: 245-54. PMID 22019450 DOI: 10.1016/j.bbamcr.2011.10.002  1
2012 Cheng HY, Dong A, Panchatcharam M, Mueller P, Yang F, Li Z, Mills G, Chun J, Morris AJ, Smyth SS. Lysophosphatidic acid signaling protects pulmonary vasculature from hypoxia-induced remodeling. Arteriosclerosis, Thrombosis, and Vascular Biology. 32: 24-32. PMID 22015657 DOI: 10.1161/ATVBAHA.111.234708  1
2012 Mutoh T, Rivera R, Chun J. Insights into the pharmacological relevance of lysophospholipid receptors. British Journal of Pharmacology. 165: 829-44. PMID 21838759 DOI: 10.1111/j.1476-5381.2011.01622.x  1
2011 Akahoshi N, Ishizaki Y, Yasuda H, Murashima YL, Shinba T, Goto K, Himi T, Chun J, Ishii I. Frequent spontaneous seizures followed by spatial working memory/anxiety deficits in mice lacking sphingosine 1-phosphate receptor 2. Epilepsy & Behavior : E&B. 22: 659-65. PMID 22019019 DOI: 10.1016/j.yebeh.2011.09.002  1
2011 Castilla-Ortega E, Hoyo-Becerra C, Pedraza C, Chun J, Rodríguez De Fonseca F, Estivill-Torrús G, Santín LJ. Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA₁ receptor knockout mice. Plos One. 6: e25522. PMID 21980482 DOI: 10.1371/journal.pone.0025522  1
2011 Chun J, Brinkmann V. A mechanistically novel, first oral therapy for multiple sclerosis: the development of fingolimod (FTY720, Gilenya). Discovery Medicine. 12: 213-28. PMID 21955849  1
2011 Yung YC, Mutoh T, Lin ME, Noguchi K, Rivera RR, Choi JW, Kingsbury MA, Chun J. Lysophosphatidic acid signaling may initiate fetal hydrocephalus. Science Translational Medicine. 3: 99ra87. PMID 21900594 DOI: 10.1126/scitranslmed.3002095  1
2011 Herr KJ, Herr DR, Lee CW, Noguchi K, Chun J. Stereotyped fetal brain disorganization is induced by hypoxia and requires lysophosphatidic acid receptor 1 (LPA1) signaling. Proceedings of the National Academy of Sciences of the United States of America. 108: 15444-9. PMID 21878565 DOI: 10.1073/pnas.1106129108  1
2011 Peterson SE, Westra JW, Rehen SK, Young H, Bushman DM, Paczkowski CM, Yung YC, Lynch CL, Tran HT, Nickey KS, Wang YC, Laurent LC, Loring JF, Carpenter MK, Chun J. Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy. Plos One. 6: e23018. PMID 21857983 DOI: 10.1371/journal.pone.0023018  1
2011 Peterson SE, Chun J, Loring J. FISH analysis of human pluripotent stem cells. Methods in Molecular Biology (Clifton, N.J.). 767: 191-200. PMID 21822876 DOI: 10.1007/978-1-61779-201-4_14  1
2011 Zhao J, He D, Su Y, Berdyshev E, Chun J, Natarajan V, Zhao Y. Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs. American Journal of Physiology. Lung Cellular and Molecular Physiology. 301: L547-56. PMID 21821728 DOI: 10.1152/ajplung.00058.2011  1
2011 Gennero I, Laurencin-Dalicieux S, Conte-Auriol F, Briand-Mésange F, Laurencin D, Rue J, Beton N, Malet N, Mus M, Tokumura A, Bourin P, Vico L, Brunel G, Oreffo RO, Chun J, et al. Absence of the lysophosphatidic acid receptor LPA1 results in abnormal bone development and decreased bone mass. Bone. 49: 395-403. PMID 21569876 DOI: 10.1016/j.bone.2011.04.018  1
2011 Zhou Z, Subramanian P, Sevilmis G, Globke B, Soehnlein O, Karshovska E, Megens R, Heyll K, Chun J, Saulnier-Blache JS, Reinholz M, van Zandvoort M, Weber C, Schober A. Lipoprotein-derived lysophosphatidic acid promotes atherosclerosis by releasing CXCL1 from the endothelium. Cell Metabolism. 13: 592-600. PMID 21531341 DOI: 10.1016/j.cmet.2011.02.016  1
2011 Zhao C, Sardella A, Chun J, Poubelle PE, Fernandes MJ, Bourgoin SG. TNF-alpha promotes LPA1- and LPA3-mediated recruitment of leukocytes in vivo through CXCR2 ligand chemokines. Journal of Lipid Research. 52: 1307-18. PMID 21521824 DOI: 10.1194/jlr.M008045  1
2011 Cohen JA, Chun J. Mechanisms of fingolimod's efficacy and adverse effects in multiple sclerosis. Annals of Neurology. 69: 759-77. PMID 21520239 DOI: 10.1002/ana.22426  1
2011 Ye X, Herr DR, Diao H, Rivera R, Chun J. Unique uterine localization and regulation may differentiate LPA3 from other lysophospholipid receptors for its role in embryo implantation. Fertility and Sterility. 95: 2107-13, 2113.e1-4. PMID 21411082 DOI: 10.1016/j.fertnstert.2011.02.024  1
2011 Soliven B, Miron V, Chun J. The neurobiology of sphingosine 1-phosphate signaling and sphingosine 1-phosphate receptor modulators. Neurology. 76: S9-14. PMID 21339490 DOI: 10.1212/WNL.0b013e31820d9507  1
2011 Castelino FV, Seiders J, Bain G, Brooks SF, King CD, Swaney JS, Lorrain DS, Chun J, Luster AD, Tager AM. Amelioration of dermal fibrosis by genetic deletion or pharmacologic antagonism of lysophosphatidic acid receptor 1 in a mouse model of scleroderma. Arthritis and Rheumatism. 63: 1405-15. PMID 21305523 DOI: 10.1002/art.30262  1
2011 Hopson KP, Truelove J, Chun J, Wang Y, Waeber C. S1P activates store-operated calcium entry via receptor- and non-receptor-mediated pathways in vascular smooth muscle cells. American Journal of Physiology. Cell Physiology. 300: C919-26. PMID 21270296 DOI: 10.1152/ajpcell.00350.2010  1
2011 Choi JW, Gardell SE, Herr DR, Rivera R, Lee CW, Noguchi K, Teo ST, Yung YC, Lu M, Kennedy G, Chun J. FTY720 (fingolimod) efficacy in an animal model of multiple sclerosis requires astrocyte sphingosine 1-phosphate receptor 1 (S1P1) modulation. Proceedings of the National Academy of Sciences of the United States of America. 108: 751-6. PMID 21177428 DOI: 10.1073/pnas.1014154108  1
2011 Noguchi K, Chun J. Roles for lysophospholipid S1P receptors in multiple sclerosis. Critical Reviews in Biochemistry and Molecular Biology. 46: 2-10. PMID 20979571 DOI: 10.3109/10409238.2010.522975  1
2011 Diao H, Aplin JD, Xiao S, Chun J, Li Z, Chen S, Ye X. Altered spatiotemporal expression of collagen types I, III, IV, and VI in Lpar3-deficient peri-implantation mouse uterus. Biology of Reproduction. 84: 255-65. PMID 20864640 DOI: 10.1095/biolreprod.110.086942  1
2010 Birgbauer E, Chun J. Lysophospholipid receptors LPA1-3 are not required for the inhibitory effects of LPA on mouse retinal growth cones. Eye and Brain. 2: 1-13. PMID 26966392 DOI: 10.2147/EB.S7666  1
2010 Herzog C, Schmitz M, Levkau B, Herrgott I, Mersmann J, Larmann J, Johanning K, Winterhalter M, Chun J, Müller FU, Echtermeyer F, Hildebrand R, Theilmeier G. Intravenous sphingosylphosphorylcholine protects ischemic and postischemic myocardial tissue in a mouse model of myocardial ischemia/reperfusion injury. Mediators of Inflammation. 2010: 425191. PMID 21274265 DOI: 10.1155/2010/425191  1
2010 Chun J, Hla T, Lynch KR, Spiegel S, Moolenaar WH. International Union of Basic and Clinical Pharmacology. LXXVIII. Lysophospholipid receptor nomenclature. Pharmacological Reviews. 62: 579-87. PMID 21079037 DOI: 10.1124/pr.110.003111  1
2010 Nagai J, Uchida H, Matsushita Y, Yano R, Ueda M, Niwa M, Aoki J, Chun J, Ueda H. Autotaxin and lysophosphatidic acid1 receptor-mediated demyelination of dorsal root fibers by sciatic nerve injury and intrathecal lysophosphatidylcholine. Molecular Pain. 6: 78. PMID 21062487 DOI: 10.1186/1744-8069-6-78  1
2010 Lee CW, Choi JW, Chun J. Neurological S1P signaling as an emerging mechanism of action of oral FTY720 (fingolimod) in multiple sclerosis. Archives of Pharmacal Research. 33: 1567-74. PMID 21052934 DOI: 10.1007/s12272-010-1008-5  1
2010 Westra JW, Rivera RR, Bushman DM, Yung YC, Peterson SE, Barral S, Chun J. Neuronal DNA content variation (DCV) with regional and individual differences in the human brain. The Journal of Comparative Neurology. 518: 3981-4000. PMID 20737596 DOI: 10.1002/cne.22436  1
2010 Lin S, Lee SJ, Shim H, Chun J, Yun CC. The absence of LPA receptor 2 reduces the tumorigenesis by ApcMin mutation in the intestine. American Journal of Physiology. Gastrointestinal and Liver Physiology. 299: G1128-38. PMID 20724530 DOI: 10.1152/ajpgi.00321.2010  1
2010 Dubin AE, Herr DR, Chun J. Diversity of lysophosphatidic acid receptor-mediated intracellular calcium signaling in early cortical neurogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7300-9. PMID 20505096 DOI: 10.1523/JNEUROSCI.6151-09.2010  1
2010 Xie W, Uchida H, Nagai J, Ueda M, Chun J, Ueda H. Calpain-mediated down-regulation of myelin-associated glycoprotein in lysophosphatidic acid-induced neuropathic pain. Journal of Neurochemistry. 113: 1002-11. PMID 20420580 DOI: 10.1111/j.1471-4159.2010.06664.x  1
2010 Castilla-Ortega E, Sánchez-López J, Hoyo-Becerra C, Matas-Rico E, Zambrana-Infantes E, Chun J, De Fonseca FR, Pedraza C, Estivill-Torrús G, Santin LJ. Exploratory, anxiety and spatial memory impairments are dissociated in mice lacking the LPA1 receptor. Neurobiology of Learning and Memory. 94: 73-82. PMID 20388543 DOI: 10.1016/j.nlm.2010.04.003  1
2010 Lin ME, Herr DR, Chun J. Lysophosphatidic acid (LPA) receptors: signaling properties and disease relevance. Prostaglandins & Other Lipid Mediators. 91: 130-8. PMID 20331961 DOI: 10.1016/j.prostaglandins.2009.02.002  1
2010 Diao H, Xiao S, Cui J, Chun J, Xu Y, Ye X. Progesterone receptor-mediated up-regulation of transthyretin in preimplantation mouse uterus. Fertility and Sterility. 93: 2750-3. PMID 20188365 DOI: 10.1016/j.fertnstert.2010.01.009  1
2010 Shea BS, Brooks SF, Fontaine BA, Chun J, Luster AD, Tager AM. Prolonged exposure to sphingosine 1-phosphate receptor-1 agonists exacerbates vascular leak, fibrosis, and mortality after lung injury. American Journal of Respiratory Cell and Molecular Biology. 43: 662-73. PMID 20081052 DOI: 10.1165/rcmb.2009-0345OC  1
2010 Chun J, Hartung HP. Mechanism of action of oral fingolimod (FTY720) in multiple sclerosis. Clinical Neuropharmacology. 33: 91-101. PMID 20061941 DOI: 10.1097/WNF.0b013e3181cbf825  1
2010 Imasawa T, Koike K, Ishii I, Chun J, Yatomi Y. Blockade of sphingosine 1-phosphate receptor 2 signaling attenuates streptozotocin-induced apoptosis of pancreatic beta-cells. Biochemical and Biophysical Research Communications. 392: 207-11. PMID 20060809 DOI: 10.1016/j.bbrc.2010.01.016  1
2010 Choi JW, Herr DR, Noguchi K, Yung YC, Lee CW, Mutoh T, Lin ME, Teo ST, Park KE, Mosley AN, Chun J. LPA receptors: subtypes and biological actions. Annual Review of Pharmacology and Toxicology. 50: 157-86. PMID 20055701 DOI: 10.1146/annurev.pharmtox.010909.105753  1
2010 Ye X, Chun J. Lysophosphatidic acid (LPA) signaling in vertebrate reproduction. Trends in Endocrinology and Metabolism: Tem. 21: 17-24. PMID 19836970 DOI: 10.1016/j.tem.2009.08.003  1
2010 Lin S, Yeruva S, He P, Singh AK, Zhang H, Chen M, Lamprecht G, de Jonge HR, Tse M, Donowitz M, Hogema BM, Chun J, Seidler U, Yun CC. Lysophosphatidic acid stimulates the intestinal brush border Na(+)/H(+) exchanger 3 and fluid absorption via LPA(5) and NHERF2. Gastroenterology. 138: 649-58. PMID 19800338 DOI: 10.1053/j.gastro.2009.09.055  1
2010 Takuwa N, Ohkura S, Takashima S, Ohtani K, Okamoto Y, Tanaka T, Hirano K, Usui S, Wang F, Du W, Yoshioka K, Banno Y, Sasaki M, Ichi I, Okamura M, ... ... Chun J, et al. S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species. Cardiovascular Research. 85: 484-93. PMID 19755413 DOI: 10.1093/cvr/cvp312  1
2009 Zhao Y, Tong J, He D, Pendyala S, Evgeny B, Chun J, Sperling AI, Natarajan V. Role of lysophosphatidic acid receptor LPA2 in the development of allergic airway inflammation in a murine model of asthma. Respiratory Research. 10: 114. PMID 19930563 DOI: 10.1186/1465-9921-10-114  1
2009 Ma L, Uchida H, Nagai J, Inoue M, Chun J, Aoki J, Ueda H. Lysophosphatidic acid-3 receptor-mediated feed-forward production of lysophosphatidic acid: an initiator of nerve injury-induced neuropathic pain. Molecular Pain. 5: 64. PMID 19912636 DOI: 10.1186/1744-8069-5-64  1
2009 Jenne CN, Enders A, Rivera R, Watson SR, Bankovich AJ, Pereira JP, Xu Y, Roots CM, Beilke JN, Banerjee A, Reiner SL, Miller SA, Weinmann AS, Goodnow CC, Lanier LL, ... ... Chun J, et al. T-bet-dependent S1P5 expression in NK cells promotes egress from lymph nodes and bone marrow. The Journal of Experimental Medicine. 206: 2469-81. PMID 19808259 DOI: 10.1084/jem.20090525  1
2009 Trimbuch T, Beed P, Vogt J, Schuchmann S, Maier N, Kintscher M, Breustedt J, Schuelke M, Streu N, Kieselmann O, Brunk I, Laube G, Strauss U, Battefeld A, Wende H, ... ... Chun J, et al. Synaptic PRG-1 modulates excitatory transmission via lipid phosphate-mediated signaling. Cell. 138: 1222-35. PMID 19766573 DOI: 10.1016/j.cell.2009.06.050  1
2009 Westra JW, Barral S, Chun J. A reevaluation of tetraploidy in the Alzheimer's disease brain. Neuro-Degenerative Diseases. 6: 221-9. PMID 19738367 DOI: 10.1159/000236901  1
2009 Teo ST, Yung YC, Herr DR, Chun J. Lysophosphatidic acid in vascular development and disease. Iubmb Life. 61: 791-9. PMID 19621353 DOI: 10.1002/iub.220  1
2009 McConnell MJ, MacMillan HR, Chun J. Mathematical modeling supports substantial mouse neural progenitor cell death. Neural Development. 4: 28. PMID 19602274 DOI: 10.1186/1749-8104-4-28  1
2009 Gon Y, Wood MR, Kiosses WB, Jo E, Sanna MG, Chun J, Rosen H. Retraction for "S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF". Proceedings of the National Academy of Sciences of the United States of America. 106: 12561. PMID 19590011 DOI: 10.1073/pnas.0906977106  1
2009 Yung YC, Kennedy G, Chun J. Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 3.8. PMID 19575470 DOI: 10.1002/0471142301.ns0308s48  1
2009 Lin S, Wang D, Iyer S, Ghaleb AM, Shim H, Yang VW, Chun J, Yun CC. The absence of LPA2 attenuates tumor formation in an experimental model of colitis-associated cancer. Gastroenterology. 136: 1711-20. PMID 19328876 DOI: 10.1053/j.gastro.2009.01.002  1
2009 Noguchi K, Herr D, Mutoh T, Chun J. Lysophosphatidic acid (LPA) and its receptors. Current Opinion in Pharmacology. 9: 15-23. PMID 19119080 DOI: 10.1016/j.coph.2008.11.010  1
2009 Ikeda H, Watanabe N, Ishii I, Shimosawa T, Kume Y, Tomiya T, Inoue Y, Nishikawa T, Ohtomo N, Tanoue Y, Iitsuka S, Fujita R, Omata M, Chun J, Yatomi Y. Sphingosine 1-phosphate regulates regeneration and fibrosis after liver injury via sphingosine 1-phosphate receptor 2. Journal of Lipid Research. 50: 556-64. PMID 18955732 DOI: 10.1194/jlr.M800496-JLR200  1
2008 Xie W, Matsumoto M, Chun J, Ueda H. Involvement of LPA1 receptor signaling in the reorganization of spinal input through Abeta-fibers in mice with partial sciatic nerve injury. Molecular Pain. 4: 46. PMID 18854053 DOI: 10.1186/1744-8069-4-46  1
2008 Mutoh T, Chun J. Lysophospholipid activation of G protein-coupled receptors. Sub-Cellular Biochemistry. 49: 269-97. PMID 18751915 DOI: 10.1007/978-1-4020-8831-5_10  1
2008 Matas-Rico E, García-Diaz B, Llebrez-Zayas P, López-Barroso D, Santín L, Pedraza C, Smith-Fernández A, Fernández-Llebrez P, Tellez T, Redondo M, Chun J, De Fonseca FR, Estivill-Torrús G. Deletion of lysophosphatidic acid receptor LPA1 reduces neurogenesis in the mouse dentate gyrus. Molecular and Cellular Neurosciences. 39: 342-55. PMID 18708146 DOI: 10.1016/j.mcn.2008.07.014  1
2008 Panchatcharam M, Miriyala S, Yang F, Rojas M, End C, Vallant C, Dong A, Lynch K, Chun J, Morris AJ, Smyth SS. Lysophosphatidic acid receptors 1 and 2 play roles in regulation of vascular injury responses but not blood pressure. Circulation Research. 103: 662-70. PMID 18703779 DOI: 10.1161/CIRCRESAHA.108.180778  1
2008 Ye X, Skinner MK, Kennedy G, Chun J. Age-dependent loss of sperm production in mice via impaired lysophosphatidic acid signaling. Biology of Reproduction. 79: 328-36. PMID 18448840 DOI: 10.1095/biolreprod.108.068783  1
2008 Choi JW, Lee CW, Chun J. Biological roles of lysophospholipid receptors revealed by genetic null mice: an update. Biochimica Et Biophysica Acta. 1781: 531-9. PMID 18407842 DOI: 10.1016/j.bbalip.2008.03.004  1
2008 Peterson SE, Westra JW, Paczkowski CM, Chun J. Chromosomal mosaicism in neural stem cells. Methods in Molecular Biology (Clifton, N.J.). 438: 197-204. PMID 18369759 DOI: 10.1007/978-1-59745-133-8_16  1
2008 Niessen F, Schaffner F, Furlan-Freguia C, Pawlinski R, Bhattacharjee G, Chun J, Derian CK, Andrade-Gordon P, Rosen H, Ruf W. Dendritic cell PAR1-S1P3 signalling couples coagulation and inflammation. Nature. 452: 654-8. PMID 18305483 DOI: 10.1038/nature06663  1
2008 Means CK, Miyamoto S, Chun J, Brown JH. S1P1 receptor localization confers selectivity for Gi-mediated cAMP and contractile responses. The Journal of Biological Chemistry. 283: 11954-63. PMID 18296752 DOI: 10.1074/jbc.M707422200  1
2008 Westra JW, Peterson SE, Yung YC, Mutoh T, Barral S, Chun J. Aneuploid mosaicism in the developing and adult cerebellar cortex. The Journal of Comparative Neurology. 507: 1944-51. PMID 18273885 DOI: 10.1002/cne.21648  1
2008 Inoue M, Ma L, Aoki J, Chun J, Ueda H. Autotaxin, a synthetic enzyme of lysophosphatidic acid (LPA), mediates the induction of nerve-injured neuropathic pain. Molecular Pain. 4: 6. PMID 18261210 DOI: 10.1186/1744-8069-4-6  1
2008 Spohr TC, de Sampaio E Spohr TC, Choi JW, Gardell SE, Herr DR, Rehen SK, Gomes FC, Chun J. Lysophosphatidic acid receptor-dependent secondary effects via astrocytes promote neuronal differentiation. The Journal of Biological Chemistry. 283: 7470-9. PMID 18198181 DOI: 10.1074/jbc.M707758200  1
2008 Lee CW, Kim NH, Choi HK, Sun Y, Nam JS, Rhee HJ, Chun J, Huh SO. Lysophosphatidic acid-induced c-fos up-regulation involves cyclic AMP response element-binding protein activated by mitogen- and stress-activated protein kinase-1. Journal of Cellular Biochemistry. 104: 785-94. PMID 18172855 DOI: 10.1002/jcb.21663  1
2008 Tager AM, LaCamera P, Shea BS, Campanella GS, Selman M, Zhao Z, Polosukhin V, Wain J, Karimi-Shah BA, Kim ND, Hart WK, Pardo A, Blackwell TS, Xu Y, Chun J, et al. The lysophosphatidic acid receptor LPA1 links pulmonary fibrosis to lung injury by mediating fibroblast recruitment and vascular leak. Nature Medicine. 14: 45-54. PMID 18066075 DOI: 10.1038/nm1685  1
2008 Shano S, Moriyama R, Chun J, Fukushima N. Lysophosphatidic acid stimulates astrocyte proliferation through LPA1. Neurochemistry International. 52: 216-20. PMID 17692995 DOI: 10.1016/j.neuint.2007.07.004  1
2008 Estivill-Torrús G, Llebrez-Zayas P, Matas-Rico E, Santín L, Pedraza C, De Diego I, Del Arco I, Fernández-Llebrez P, Chun J, De Fonseca FR. Absence of LPA1 signaling results in defective cortical development. Cerebral Cortex (New York, N.Y. : 1991). 18: 938-50. PMID 17656621 DOI: 10.1093/cercor/bhm132  1
2007 Hama K, Aoki J, Inoue A, Endo T, Amano T, Motoki R, Kanai M, Ye X, Chun J, Matsuki N, Suzuki H, Shibasaki M, Arai H. Embryo spacing and implantation timing are differentially regulated by LPA3-mediated lysophosphatidic acid signaling in mice. Biology of Reproduction. 77: 954-9. PMID 17823089 DOI: 10.1095/biolreprod.107.060293  1
2007 Chan LC, Peters W, Xu Y, Chun J, Farese RV, Cases S. LPA3 receptor mediates chemotaxis of immature murine dendritic cells to unsaturated lysophosphatidic acid (LPA). Journal of Leukocyte Biology. 82: 1193-200. PMID 17709403 DOI: 10.1189/jlb.0407221  1
2007 Rajendran RS, Zupanc MM, Lösche A, Westra J, Chun J, Zupanc GK. Numerical chromosome variation and mitotic segregation defects in the adult brain of teleost fish. Developmental Neurobiology. 67: 1334-47. PMID 17638379 DOI: 10.1002/dneu.20365  1
2007 Chun J. Immunology. The sources of a lipid conundrum. Science (New York, N.Y.). 316: 208-10. PMID 17431159 DOI: 10.1126/science.1142239  1
2007 Means CK, Xiao CY, Li Z, Zhang T, Omens JH, Ishii I, Chun J, Brown JH. Sphingosine 1-phosphate S1P2 and S1P3 receptor-mediated Akt activation protects against in vivo myocardial ischemia-reperfusion injury. American Journal of Physiology. Heart and Circulatory Physiology. 292: H2944-51. PMID 17293497 DOI: 10.1152/ajpheart.01331.2006  1
2007 Herr DR, Grillet N, Schwander M, Rivera R, Müller U, Chun J. Sphingosine 1-phosphate (S1P) signaling is required for maintenance of hair cells mainly via activation of S1P2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1474-8. PMID 17287522 DOI: 10.1523/JNEUROSCI.4245-06.2007  1
2007 Lee CW, Rivera R, Dubin AE, Chun J. LPA(4)/GPR23 is a lysophosphatidic acid (LPA) receptor utilizing G(s)-, G(q)/G(i)-mediated calcium signaling and G(12/13)-mediated Rho activation. The Journal of Biological Chemistry. 282: 4310-7. PMID 17166850 DOI: 10.1074/jbc.M610826200  1
2007 Walter DH, Rochwalsky U, Reinhold J, Seeger F, Aicher A, Urbich C, Spyridopoulos I, Chun J, Brinkmann V, Keul P, Levkau B, Zeiher AM, Dimmeler S, Haendeler J. Sphingosine-1-phosphate stimulates the functional capacity of progenitor cells by activation of the CXCR4-dependent signaling pathway via the S1P3 receptor. Arteriosclerosis, Thrombosis, and Vascular Biology. 27: 275-82. PMID 17158356 DOI: 10.1161/01.ATV.0000254669.12675.70  1
2007 Fukushima N, Shano S, Moriyama R, Chun J. Lysophosphatidic acid stimulates neuronal differentiation of cortical neuroblasts through the LPA1-G(i/o) pathway. Neurochemistry International. 50: 302-7. PMID 17056154 DOI: 10.1016/j.neuint.2006.09.008  1
2006 Theilmeier G, Schmidt C, Herrmann J, Keul P, Schäfers M, Herrgott I, Mersmann J, Larmann J, Hermann S, Stypmann J, Schober O, Hildebrand R, Schulz R, Heusch G, Haude M, ... ... Chun J, et al. High-density lipoproteins and their constituent, sphingosine-1-phosphate, directly protect the heart against ischemia/reperfusion injury in vivo via the S1P3 lysophospholipid receptor. Circulation. 114: 1403-9. PMID 16982942 DOI: 10.1161/CIRCULATIONAHA.105.607135  1
2006 Inoue M, Yamaguchi A, Kawakami M, Chun J, Ueda H. Loss of spinal substance P pain transmission under the condition of LPA1 receptor-mediated neuropathic pain. Molecular Pain. 2: 25. PMID 16914035 DOI: 10.1186/1744-8069-2-25  1
2006 Rehen SK, Kingsbury MA, Almeida BS, Herr DR, Peterson S, Chun J. A new method of embryonic culture for assessing global changes in brain organization. Journal of Neuroscience Methods. 158: 100-8. PMID 16824613 DOI: 10.1016/j.jneumeth.2006.05.025  1
2006 Lee CW, Rivera R, Gardell S, Dubin AE, Chun J. GPR92 as a new G12/13- and Gq-coupled lysophosphatidic acid receptor that increases cAMP, LPA5. The Journal of Biological Chemistry. 281: 23589-97. PMID 16774927 DOI: 10.1074/jbc.M603670200  1
2006 Chao C, Herr D, Chun J, Xu Y. Ser18 and 23 phosphorylation is required for p53-dependent apoptosis and tumor suppression. The Embo Journal. 25: 2615-22. PMID 16757976 DOI: 10.1038/sj.emboj.7601167  1
2006 Chun J, Rosen H. Lysophospholipid receptors as potential drug targets in tissue transplantation and autoimmune diseases. Current Pharmaceutical Design. 12: 161-71. PMID 16454733  1
2006 Gardell SE, Dubin AE, Chun J. Emerging medicinal roles for lysophospholipid signaling. Trends in Molecular Medicine. 12: 65-75. PMID 16406843 DOI: 10.1016/j.molmed.2005.12.001  1
2005 Chun J. Lysophospholipids in the nervous system Prostaglandins and Other Lipid Mediators. 77: 46-51. PMID 16099390 DOI: 10.1016/j.prostaglandins.2004.09.009  1
2005 Gon Y, Wood MR, Kiosses WB, Jo E, Sanna MG, Chun J, Rosen H. S1P3 receptor-induced reorganization of epithelial tight junctions compromises lung barrier integrity and is potentiated by TNF Proceedings of the National Academy of Sciences of the United States of America. 102: 9270-9275. PMID 15968000 DOI: 10.1073/pnas.0501997102  1
2005 Ye X, Hama K, Contos JJ, Anliker B, Inoue A, Skinner MK, Suzuki H, Amano T, Kennedy G, Arai H, Aoki J, Chun J. LPA3-mediated lysophosphatidic acid signalling in embryo implantation and spacing. Nature. 435: 104-8. PMID 15875025 DOI: 10.1038/nature03505  1
2005 Goparaju SK, Jolly PS, Watterson KR, Bektas M, Alvarez S, Sarkar S, Mel L, Ishii I, Chun J, Milstien S, Spiegel S. The S1P2 receptor negatively regulates platelet-derived growth factor-induced motility and proliferation. Molecular and Cellular Biology. 25: 4237-49. PMID 15870293 DOI: 10.1128/MCB.25.10.4237-4249.2005  1
2005 Tölle M, Levkau B, Keul P, Brinkmann V, Giebing G, Schönfelder G, Schäfers M, von Wnuck Lipinski K, Jankowski J, Jankowski V, Chun J, Zidek W, Van der Giet M. Immunomodulator FTY720 Induces eNOS-dependent arterial vasodilatation via the lysophospholipid receptor S1P3. Circulation Research. 96: 913-20. PMID 15802614 DOI: 10.1161/01.RES.0000164321.91452.00  1
2005 Rehen SK, Yung YC, McCreight MP, Kaushal D, Yang AH, Almeida BS, Kingsbury MA, Cabral KM, McConnell MJ, Anliker B, Fontanoz M, Chun J. Constitutional aneuploidy in the normal human brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2176-80. PMID 15745943 DOI: 10.1523/JNEUROSCI.4560-04.2005  1
2005 Li H, Ye X, Mahanivong C, Bian D, Chun J, Huang S. Signaling mechanisms responsible for lysophosphatidic acid-induced urokinase plasminogen activator expression in ovarian cancer cells. The Journal of Biological Chemistry. 280: 10564-71. PMID 15653692 DOI: 10.1074/jbc.M412152200  1
2004 Levkau B, Hermann S, Theilmeier G, van der Giet M, Chun J, Schober O, Schäfers M. High-density lipoprotein stimulates myocardial perfusion in vivo. Circulation. 110: 3355-9. PMID 15545521 DOI: 10.1161/01.CIR.0000147827.43912.AE  1
2004 McConnell MJ, Kaushal D, Yang AH, Kingsbury MA, Rehen SK, Treuner K, Helton R, Annas EG, Chun J, Barlow C. Failed clearance of aneuploid embryonic neural progenitor cells leads to excess aneuploidy in the Atm-deficient but not the Trp53-deficient adult cerebral cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 8090-6. PMID 15371510 DOI: 10.1523/JNEUROSCI.2263-04.2004  1
2004 Anliker B, Chun J. Cell surface receptors in lysophospholipid signaling. Seminars in Cell & Developmental Biology. 15: 457-65. PMID 15271291 DOI: 10.1016/j.semcdb.2004.05.005  1
2004 Webb M, Tham CS, Lin FF, Lariosa-Willingham K, Yu N, Hale J, Mandala S, Chun J, Rao TS. Sphingosine 1-phosphate receptor agonists attenuate relapsing-remitting experimental autoimmune encephalitis in SJL mice Journal of Neuroimmunology. 153: 108-121. PMID 15265669 DOI: 10.1016/j.jneuroim.2004.04.015  1
2004 Inoue M, Rashid MH, Fujita R, Contos JJ, Chun J, Ueda H. Initiation of neuropathic pain requires lysophosphatidic acid receptor signaling. Nature Medicine. 10: 712-8. PMID 15195086 DOI: 10.1038/nm1060  1
2004 Ishii I, Fukushima N, Ye X, Chun J. Lysophospholipid receptors: signaling and biology. Annual Review of Biochemistry. 73: 321-54. PMID 15189145 DOI: 10.1146/annurev.biochem.73.011303.073731  1
2004 Anliker B, Chun J. Lysophospholipid G protein-coupled receptors. The Journal of Biological Chemistry. 279: 20555-8. PMID 15023998 DOI: 10.1074/jbc.R400013200  1
2004 Nofer JR, van der Giet M, Tölle M, Wolinska I, von Wnuck Lipinski K, Baba HA, Tietge UJ, Gödecke A, Ishii I, Kleuser B, Schäfers M, Fobker M, Zidek W, Assmann G, Chun J, et al. HDL induces NO-dependent vasorelaxation via the lysophospholipid receptor S1P3. The Journal of Clinical Investigation. 113: 569-81. PMID 14966566 DOI: 10.1172/JCI18004  1
2004 Baudhuin LM, Jiang Y, Zaslavsky A, Ishii I, Chun J, Xu Y. S1P3-mediated Akt activation and cross-talk with platelet-derived growth factor receptor (PDGFR). Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 18: 341-3. PMID 14657000 DOI: 10.1096/fj.03-0302fje  1
2003 Kingsbury MA, Rehen SK, Contos JJ, Higgins CM, Chun J. Non-proliferative effects of lysophosphatidic acid enhance cortical growth and folding. Nature Neuroscience. 6: 1292-9. PMID 14625558 DOI: 10.1038/nn1157  1
2003 Yang AH, Kaushal D, Rehen SK, Kriedt K, Kingsbury MA, McConnell MJ, Chun J. Chromosome segregation defects contribute to aneuploidy in normal neural progenitor cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 10454-62. PMID 14614104  1
2003 Olivera A, Rosenfeldt HM, Bektas M, Wang F, Ishii I, Chun J, Milstien S, Spiegel S. Sphingosine kinase type 1 induces G12/13-mediated stress fiber formation, yet promotes growth and survival independent of G protein-coupled receptors. The Journal of Biological Chemistry. 278: 46452-60. PMID 12963721 DOI: 10.1074/jbc.M308749200  1
2003 Kaushal D, Contos JJ, Treuner K, Yang AH, Kingsbury MA, Rehen SK, McConnell MJ, Okabe M, Barlow C, Chun J. Alteration of gene expression by chromosome loss in the postnatal mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5599-606. PMID 12843262  1
2003 Liu H, Toman RE, Goparaju SK, Maceyka M, Nava VE, Sankala H, Payne SG, Bektas M, Ishii I, Chun J, Milstien S, Spiegel S. Sphingosine kinase type 2 is a putative BH3-only protein that induces apoptosis. The Journal of Biological Chemistry. 278: 40330-6. PMID 12835323 DOI: 10.1074/jbc.M304455200  1
2003 Zhao X, Ueba T, Christie BR, Barkho B, McConnell MJ, Nakashima K, Lein ES, Eadie BD, Willhoite AR, Muotri AR, Summers RG, Chun J, Lee KF, Gage FH. Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proceedings of the National Academy of Sciences of the United States of America. 100: 6777-82. PMID 12748381 DOI: 10.1073/pnas.1131928100  1
2002 Ye X, Ishii I, Kingsbury MA, Chun J. Lysophosphatidic acid as a novel cell survival/apoptotic factor. Biochimica Et Biophysica Acta. 1585: 108-13. PMID 12531543 DOI: 10.1016/S1388-1981(02)00330-X  1
2002 Ye X, Fukushima N, Kingsbury MA, Chun J. Lysophosphatidic acid in neural signaling. Neuroreport. 13: 2169-75. PMID 12488791 DOI: 10.1097/00001756-200212030-00002  1
2002 Fukushima N, Ye X, Chun J. Neurobiology of lysophosphatidic acid signaling Neuroscientist. 8: 540-550. PMID 12467376 DOI: 10.1177/1073858402238513  1
2002 McGiffert C, Contos JJ, Friedman B, Chun J. Embryonic brain expression analysis of lysophospholipid receptor genes suggests roles for s1p(1) in neurogenesis and s1p(1-3) in angiogenesis. Febs Letters. 531: 103-8. PMID 12401212 DOI: 10.1016/S0014-5793(02)03404-X  1
2002 Contos JJ, Ye X, Sah VP, Chun J. Tandem genomic arrangement of a G protein (Gna15) and G protein-coupled receptor (s1p(4)/lp(C1)/Edg6) gene. Febs Letters. 531: 99-102. PMID 12401211  1
2002 Contos JJ, Ishii I, Fukushima N, Kingsbury MA, Ye X, Kawamura S, Brown JH, Chun J. Characterization of lpa(2) (Edg4) and lpa(1)/lpa(2) (Edg2/Edg4) lysophosphatidic acid receptor knockout mice: signaling deficits without obvious phenotypic abnormality attributable to lpa(2). Molecular and Cellular Biology. 22: 6921-9. PMID 12215548 DOI: 10.1128/MCB.22.19.6921-6929.2002  1
2002 Fukushima N, Ishii I, Habara Y, Allen CB, Chun J. Dual regulation of actin rearrangement through lysophosphatidic acid receptor in neuroblast cell lines: actin depolymerization by Ca(2+)-alpha-actinin and polymerization by rho. Molecular Biology of the Cell. 13: 2692-705. PMID 12181339 DOI: 10.1091/mbc.01-09-0465  1
2002 Fukushima N, Weiner JA, Kaushal D, Contos JJ, Rehen SK, Kingsbury MA, Kim KY, Chun J. Lysophosphatidic acid influences the morphology and motility of young, postmitotic cortical neurons. Molecular and Cellular Neurosciences. 20: 271-82. PMID 12093159 DOI: 10.1006/mcne.2002.1123  1
2002 Yang AH, Ishii I, Chun J. In vivo roles of lysophospholipid receptors revealed by gene targeting studies in mice. Biochimica Et Biophysica Acta. 1582: 197-203. PMID 12069829 DOI: 10.1016/S1388-1981(02)00172-5  1
2002 Ishii I, Ye X, Friedman B, Kawamura S, Contos JJ, Kingsbury MA, Yang AH, Zhang G, Brown JH, Chun J. Marked perinatal lethality and cellular signaling deficits in mice null for the two sphingosine 1-phosphate (S1P) receptors, S1P(2)/LP(B2)/EDG-5 and S1P(3)/LP(B3)/EDG-3. The Journal of Biological Chemistry. 277: 25152-9. PMID 12006579 DOI: 10.1074/jbc.M200137200  1
2002 Ishii I, Chun J. Anandamide-induced neuroblastoma cell rounding via the CBI cannabinoid receptors Neuroreport. 13: 593-596. PMID 11973452  1
2001 Chun J, Blaschke AJ. Identification of neural programmed cell death through the detection of DNA fragmentation in situ and by PCR Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. PMID 18428472  1
2000 Pompeiano M, Blaschke AJ, Flavell RA, Srinivasan A, Chun J. Decreased apoptosis in proliferative and postmitotic regions of the Caspase 3-deficient embryonic central nervous system. The Journal of Comparative Neurology. 423: 1-12. PMID 10861532 DOI: 10.1002/1096-9861(20000717)423:1<1::AID-CNE1>3.0.CO;2-S  1
1998 Blaschke AJ, Weiner JA, Chun J. Programmed cell death is a universal feature of embryonic and postnatal neuroproliferative regions throughout the central nervous system. The Journal of Comparative Neurology. 396: 39-50. PMID 9623886 DOI: 10.1002/(SICI)1096-9861(19980622)396:1<39::AID-CNE4>3.0.CO;2-J  1
1997 Staley K, Blaschke AJ, Chun J. Apoptotic DNA fragmentation is detected by a semi-quantitative ligation-mediated PCR of blunt DNA ends. Cell Death and Differentiation. 4: 66-75. PMID 16465212 DOI: 10.1038/sj.cdd.4400207  1
1996 Blaschke AJ, Staley K, Chun J. Widespread programmed cell death in proliferative and postmitotic regions of the fetal cerebral cortex. Development (Cambridge, England). 122: 1165-74. PMID 8620843  1
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