Thiruma V Arumugam, PhD - Publications

Affiliations: 
Department of Physiology National University SIngapore 
 Pharmacology University of Queensland, Saint Lucia, Queensland, Australia 
Area:
Aging

116 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Bahn G, Park JS, Yun UJ, Lee YJ, Choi Y, Park JS, Baek SH, Choi BY, Cho YS, Kim HK, Han J, Sul JH, Baik SH, Lim J, Wakabayashi N, ... ... Arumugam TV, et al. NRF2/ARE pathway negatively regulates BACE1 expression and ameliorates cognitive deficits in mouse Alzheimer's models. Proceedings of the National Academy of Sciences of the United States of America. PMID 31164420 DOI: 10.1073/pnas.1819541116  1
2019 Zhang SR, Nold MF, Tang SC, Bui CB, Nold CA, Arumugam TV, Drummond GR, Sobey CG, Kim HA. IL-37 increases in patients after ischemic stroke and protects from inflammatory brain injury, motor impairment and lung infection in mice. Scientific Reports. 9: 6922. PMID 31061403 DOI: 10.1038/s41598-019-43364-7  1
2019 Selvaraji S, Poh L, Natarajan V, Mallilankaraman K, Arumugam TV. Negative Conditioning of Mitochondrial Dysfunction in Age-related Neurodegenerative Diseases. Conditioning Medicine. 2: 30-39. PMID 31058265  1
2019 Kim J, Selvaraji S, Wook Kang S, Thye Lee W, Li-Hsian Chen C, Choi H, Koo EH, Jo DG, Leong Lim K, Lim YA, Arumugam TV. Cerebral transcriptome analysis reveals age-dependent progression of neuroinflammation in P301S mutant tau transgenic male mice. Brain, Behavior, and Immunity. PMID 30980950 DOI: 10.1016/j.bbi.2019.04.011  1
2018 Choi BY, Choi Y, Park JS, Kang LJ, Baek SH, Park JS, Bahn G, Cho Y, Kim HK, Han J, Sul JH, Baik SH, Hyun DH, Arumugam TV, Yang S, et al. Inhibition of Notch1 induces population and suppressive activity of regulatory T cell in inflammatory arthritis. Theranostics. 8: 4795-4804. PMID 30279738 DOI: 10.7150/thno.26093  1
2018 Zhang SR, Piepke M, Chu HX, Broughton BR, Shim R, Wong CH, Lee S, Evans MA, Vinh A, Sakkal S, Arumugam TV, Magnus T, Huber S, Gelderblom M, Drummond GR, et al. IL-33 modulates inflammatory brain injury but exacerbates systemic immunosuppression following ischemic stroke. Jci Insight. 3. PMID 30232272 DOI: 10.1172/jci.insight.121560  1
2018 Poh L, Kang SW, Baik SH, Yong Quan Ng G, She DT, Balaganapathy P, Thameem Dheen S, Magnus T, Gelderblom M, Sobey CG, Koo EH, Fann DY, Arumugam TV. Evidence that NLRC4 Inflammasome Mediates Apoptotic and Pyroptotic Microglial Death Following Ischemic Stroke. Brain, Behavior, and Immunity. PMID 30195027 DOI: 10.1016/j.bbi.2018.09.001  1
2018 Mattson MP, Arumugam TV. Hallmarks of Brain Aging: Adaptive and Pathological Modification by Metabolic States. Cell Metabolism. 27: 1176-1199. PMID 29874566 DOI: 10.1016/j.cmet.2018.05.011  0.88
2018 Ng GY, Yun-An L, Sobey CG, Dheen T, Fann DY, Arumugam TV. Epigenetic regulation of inflammation in stroke. Therapeutic Advances in Neurological Disorders. 11: 1756286418771815. PMID 29774056 DOI: 10.1177/1756286418771815  1
2018 Kim J, Kang SW, Mallilankaraman K, Baik SH, Lim JC, Balaganapathy P, She DT, Lok KZ, Fann DY, Thambiayah U, Tang SC, Stranahan AM, Dheen ST, Gelderblom M, Seet RC, ... ... Arumugam TV, et al. Transcriptome analysis reveals intermittent fasting-induced genetic changes in ischemic stroke. Human Molecular Genetics. PMID 29688516 DOI: 10.1093/hmg/ddy138  1
2018 She DT, Wong LJ, Baik SH, Arumugam TV. SIRT2 Inhibition Confers Neuroprotection by Downregulation of FOXO3a and MAPK Signaling Pathways in Ischemic Stroke. Molecular Neurobiology. PMID 29654491 DOI: 10.1007/s12035-018-1058-0  1
2018 Arumugam TV, Baik SH, Balaganapathy P, Sobey CG, Mattson MP, Jo DG. Notch Signaling and Neuronal Death in Stroke. Progress in Neurobiology. PMID 29574014 DOI: 10.1016/j.pneurobio.2018.03.002  1
2018 Evans MA, Kim HA, Ling YH, Uong S, Vinh A, De Silva TM, Arumugam TV, Clarkson AN, Zosky GR, Drummond GR, Broughton BRS, Sobey CG. Vitamin DSupplementation Reduces Subsequent Brain Injury and Inflammation Associated with Ischemic Stroke. Neuromolecular Medicine. PMID 29476479 DOI: 10.1007/s12017-018-8484-z  1
2018 Kim J, Kang SW, Mallilankaraman K, Baik SH, Lim JC, Balaganapathy P, She DT, Lok KZ, Fann DY, Thambiayah U, Tang SC, Stranahan AM, Dheen ST, Gelderblom M, Seet RC, ... ... Arumugam TV, et al. Transcriptome Analysis Reveals Intermittent Fasting-Induced Genetic Changes in Ischemic Stroke. Human Molecular Genetics. PMID 29447348 DOI: 10.1093/hmg/ddy057  1
2018 Evans MA, Lim R, Kim HA, Chu HX, Gardiner-Mann CV, Taylor KWE, Chan CT, Brait VH, Lee S, Dinh QN, Vinh A, Phan TG, Srikanth VK, Ma H, Arumugam TV, et al. Acute or Delayed Systemic Administration of Human Amnion Epithelial Cells Improves Outcomes in Experimental Stroke. Stroke. PMID 29382802 DOI: 10.1161/STROKEAHA.117.019136  1
2018 Chen X, Arumugam TV, Cheng YL, Lee JH, Chigurupati S, Mattson MP, Basta M. Combination Therapy with Low-Dose IVIG and a C1-esterase Inhibitor Ameliorates Brain Damage and Functional Deficits in Experimental Ischemic Stroke. Neuromolecular Medicine. PMID 29299869 DOI: 10.1007/s12017-017-8474-6  0.88
2017 Dasgupta A, Kim J, Manakkadan A, Arumugam TV, Sajikumar S. Intermittent fasting promotes prolonged associative interactions during synaptic tagging/capture by altering the metaplastic properties of the CA1 hippocampal neurons. Neurobiology of Learning and Memory. PMID 29277679 DOI: 10.1016/j.nlm.2017.12.004  0.32
2017 Evans MA, Kim HA, De Silva TM, Arumugam TV, Clarkson AN, Drummond GR, Zosky GR, Broughton BR, Sobey CG. Diet-induced vitamin D deficiency has no effect on acute post-stroke outcomes in young male mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17719208. PMID 28832249 DOI: 10.1177/0271678X17719208  1
2017 She DT, Jo DG, Arumugam TV. Emerging Roles of Sirtuins in Ischemic Stroke. Translational Stroke Research. PMID 28656393 DOI: 10.1007/s12975-017-0544-4  1
2017 Balaganapathy P, Baik SH, Mallilankaraman K, Sobey CG, Jo DG, Arumugam TV. Interplay between Notch and p53 promotes neuronal cell death in ischemic stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17715956. PMID 28617078 DOI: 10.1177/0271678X17715956  1
2017 Baek SH, Park SJ, In Jeong J, Hyun Kim S, Han J, Won Kyung J, Baik SH, Choi Y, Choi BY, Park J, Bahn G, Shin JH, Sin Jo D, Lee JY, Jang CG, ... Arumugam TV, et al. Inhibition of Drp1 Ameliorates Synaptic Depression, Aβ Deposition and Cognitive Impairment in Alzheimer's Disease Model. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28432138 DOI: 10.1523/JNEUROSCI.2385-16.2017  1
2017 Fann DY, Ng GY, Poh L, Arumugam TV. Positive effects of intermittent fasting in ischemic stroke. Experimental Gerontology. PMID 28115234 DOI: 10.1016/j.exger.2017.01.014  0.32
2017 Fann DY, Lim YA, Cheng YL, Lok KZ, Chunduri P, Baik SH, Drummond GR, Dheen ST, Sobey CG, Jo DG, Chen CL, Arumugam TV. Evidence that NF-κB and MAPK Signaling Promotes NLRP Inflammasome Activation in Neurons Following Ischemic Stroke. Molecular Neurobiology. PMID 28092085 DOI: 10.1007/s12035-017-0394-9  1
2017 Ng GJ, Quek AM, Cheung C, Arumugam TV, Seet RC. Stroke biomarkers in clinical practice: A critical appraisal. Neurochemistry International. PMID 28088349 DOI: 10.1016/j.neuint.2017.01.005  0.32
2017 Chen M, Arumugam TV, Leanage G, Tieng QM, Yadav A, Ullmann JF, She DT, Truong V, Ruitenberg MJ, Reutens DC. Disease-modifying effect of intravenous immunoglobulin in an experimental model of epilepsy. Scientific Reports. 7: 40528. PMID 28074934 DOI: 10.1038/srep40528  1
2016 Arumugam TV, Manzanero S, Furtado M, Biggins PJ, Hsieh YH, Gelderblom M, MacDonald KP, Salimova E, Li YI, Korn O, Dewar D, Macrae IM, Ashman RB, Tang SC, Rosenthal NA, et al. An atypical role for the myeloid receptor Mincle in central nervous system injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 27492949 DOI: 10.1177/0271678X16661201  0.48
2016 Kim J, Fann DY, Seet RC, Jo DG, Mattson MP, Arumugam TV. Phytochemicals in Ischemic Stroke. Neuromolecular Medicine. PMID 27193940 DOI: 10.1007/s12017-016-8403-0  1
2016 Lok KZ, Manzanero S, Arumugam TV. Neuronal low-density lipoprotein receptor-related protein 1 (LRP1) enhances the anti-apoptotic effect of intravenous immunoglobulin (IVIg) in ischemic stroke. Brain Research. 1644: 192-202. PMID 27181517 DOI: 10.1016/j.brainres.2016.05.023  0.48
2016 Wang KC, Tang SC, Lee JE, Li YI, Huang YS, Yang WS, Jeng JS, Arumugam TV, Tu YK. Cerebrospinal fluid high mobility group box 1 is associated with neuronal death in subarachnoid hemorrhage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26823474 DOI: 10.1177/0271678X16629484  0.44
2015 Madar R, Rotter A, Ben-Asher HW, Mughal MR, Arumugam TV, Wood WH, Becker KG, Mattson MP, Okun E. Postnatal TLR2 activation impairs learning and memory in adulthood. Brain, Behavior, and Immunity. PMID 26021559 DOI: 10.1016/j.bbi.2015.04.020  0.8
2015 Lok KZ, Basta M, Manzanero S, Arumugam TV. Intravenous immunoglobulin (IVIg) dampens neuronal toll-like receptor-mediated responses in ischemia. Journal of Neuroinflammation. 12: 73. PMID 25886362 DOI: 10.1186/s12974-015-0294-8  0.48
2015 Baik SH, Fane M, Park JH, Cheng YL, Yang-Wei Fann D, Yun UJ, Choi Y, Park JS, Chai BH, Park JS, Back SH, Jeong JI, Jang YJ, Bahn G, Lee JY, ... ... Arumugam TV, et al. Pin1 promotes neuronal death in stroke by stabilizing Notch intracellular domain. Annals of Neurology. 77: 504-16. PMID 25558977 DOI: 10.1002/ana.24347  0.8
2015 Cheng YL, Choi Y, Sobey CG, Arumugam TV, Jo DG. Emerging roles of the γ-secretase-notch axis in inflammation. Pharmacology & Therapeutics. 147: 80-90. PMID 25448038 DOI: 10.1016/j.pharmthera.2014.11.005  0.8
2015 Park JS, Kim SH, Kim K, Jin CH, Choi KY, Jang J, Choi Y, Gwon AR, Baik SH, Yun UJ, Chae SY, Lee S, Kang YM, Lee KC, Arumugam TV, et al. Inhibition of notch signalling ameliorates experimental inflammatory arthritis. Annals of the Rheumatic Diseases. 74: 267-74. PMID 24255545 DOI: 10.1136/annrheumdis-2013-203467  0.8
2014 Kim HA, Whittle SC, Lee S, Chu HX, Zhang SR, Wei Z, Arumugam TV, Vinh A, Drummond GR, Sobey CG. Brain immune cell composition and functional outcome after cerebral ischemia: comparison of two mouse strains. Frontiers in Cellular Neuroscience. 8: 365. PMID 25477780 DOI: 10.3389/fncel.2014.00365  1
2014 Rajaram H, Palanivelu MK, Arumugam TV, Rao VM, Shaw PN, McGeary RP, Ross BP. 'Click' assembly of glycoclusters and discovery of a trehalose analogue that retards Aβ40 aggregation and inhibits Aβ40-induced neurotoxicity. Bioorganic & Medicinal Chemistry Letters. 24: 4523-8. PMID 25172417 DOI: 10.1016/j.bmcl.2014.07.077  0.8
2014 Cheng YL, Choi Y, Seow WL, Manzanero S, Sobey CG, Jo DG, Arumugam TV. Evidence that neuronal Notch-1 promotes JNK/c-Jun activation and cell death following ischemic stress. Brain Research. 1586: 193-202. PMID 25168760 DOI: 10.1016/j.brainres.2014.08.054  0.8
2014 Widiapradja A, Santro T, Basta M, Sobey CG, Manzanero S, Arumugam TV. Intravenous immunoglobulin (IVIg) provides protection against endothelial cell dysfunction and death in ischemic stroke. Experimental & Translational Stroke Medicine. 6: 7. PMID 24991401 DOI: 10.1186/2040-7378-6-7  1
2014 Chu HX, Arumugam TV, Gelderblom M, Magnus T, Drummond GR, Sobey CG. Role of CCR2 in inflammatory conditions of the central nervous system. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 1425-9. PMID 24984897 DOI: 10.1038/jcbfm.2014.120  1
2014 Fann DY, Santro T, Manzanero S, Widiapradja A, Cheng YL, Lee SY, Chunduri P, Jo DG, Stranahan AM, Mattson MP, Arumugam TV. Intermittent fasting attenuates inflammasome activity in ischemic stroke. Experimental Neurology. 257: 114-9. PMID 24805069 DOI: 10.1016/j.expneurol.2014.04.017  0.8
2014 Low PC, Manzanero S, Mohannak N, Narayana VK, Nguyen TH, Kvaskoff D, Brennan FH, Ruitenberg MJ, Gelderblom M, Magnus T, Kim HA, Broughton BR, Sobey CG, Vanhaesebroeck B, Stow JL, ... Arumugam TV, et al. PI3Kδ inhibition reduces TNF secretion and neuroinflammation in a mouse cerebral stroke model. Nature Communications. 5: 3450. PMID 24625684 DOI: 10.1038/ncomms4450  1
2014 Manzanero S, Erion JR, Santro T, Steyn FJ, Chen C, Arumugam TV, Stranahan AM. Intermittent fasting attenuates increases in neurogenesis after ischemia and reperfusion and improves recovery. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 897-905. PMID 24549184 DOI: 10.1038/jcbfm.2014.36  0.8
2014 Broughton BR, Brait VH, Kim HA, Lee S, Chu HX, Gardiner-Mann CV, Guida E, Evans MA, Miller AA, Arumugam TV, Drummond GR, Sobey CG. Sex-dependent effects of G protein-coupled estrogen receptor activity on outcome after ischemic stroke. Stroke; a Journal of Cerebral Circulation. 45: 835-41. PMID 24457292 DOI: 10.1161/STROKEAHA.113.001499  0.8
2014 Chu HX, Kim HA, Lee S, Moore JP, Chan CT, Vinh A, Gelderblom M, Arumugam TV, Broughton BR, Drummond GR, Sobey CG. Immune cell infiltration in malignant middle cerebral artery infarction: comparison with transient cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 450-9. PMID 24326388 DOI: 10.1038/jcbfm.2013.217  1
2014 Rashid M, Wangler NJ, Yang L, Shah K, Arumugam TV, Abbruscato TJ, Karamyan VT. Functional up-regulation of endopeptidase neurolysin during post-acute and early recovery phases of experimental stroke in mouse brain. Journal of Neurochemistry. 129: 179-89. PMID 24164478 DOI: 10.1111/jnc.12513  0.44
2014 Cheng YL, Park JS, Manzanero S, Choi Y, Baik SH, Okun E, Gelderblom M, Fann DY, Magnus T, Launikonis BS, Mattson MP, Sobey CG, Jo DG, Arumugam TV. Evidence that collaboration between HIF-1α and Notch-1 promotes neuronal cell death in ischemic stroke. Neurobiology of Disease. 62: 286-95. PMID 24141018 DOI: 10.1016/j.nbd.2013.10.009  0.8
2013 Morrell CH, Shetty V, Phillips T, Arumugam TV, Mattson MP, Wan R. Testing the product of slopes in related regressions. Advances and Applications in Statistics. 36: 29-46. PMID 25346580  0.88
2013 Tang SC, Yeh SJ, Li YI, Wang YC, Baik SH, Santro T, Widiapradja A, Manzanero S, Sobey CG, Jo DG, Arumugam TV, Jeng JS. Evidence for a detrimental role of TLR8 in ischemic stroke. Experimental Neurology. 250: 341-7. PMID 24196452 DOI: 10.1016/j.expneurol.2013.10.012  0.8
2013 Fann DY, Lee SY, Manzanero S, Chunduri P, Sobey CG, Arumugam TV. Pathogenesis of acute stroke and the role of inflammasomes. Ageing Research Reviews. 12: 941-66. PMID 24103368 DOI: 10.1016/j.arr.2013.09.004  1
2013 Thundyil J, Manzanero S, Pavlovski D, Cully TR, Lok KZ, Widiapradja A, Chunduri P, Jo DG, Naruse C, Asano M, Launikonis BS, Sobey CG, Coulthard MG, Arumugam TV. Evidence that the EphA2 receptor exacerbates ischemic brain injury. Plos One. 8: e53528. PMID 23308246 DOI: 10.1371/journal.pone.0053528  1
2013 Tang SC, Wang YC, Li YI, Lin HC, Manzanero S, Hsieh YH, Phipps S, Hu CJ, Chiou HY, Huang YS, Yang WS, Mattson MP, Arumugam TV, Jeng JS. Functional role of soluble receptor for advanced glycation end products in stroke. Arteriosclerosis, Thrombosis, and Vascular Biology. 33: 585-94. PMID 23288172 DOI: 10.1161/ATVBAHA.112.300523  0.8
2013 Park JS, Manzanero S, Chang JW, Choi Y, Baik SH, Cheng YL, Li YI, Gwon AR, Woo HN, Jang J, Choi IY, Lee JY, Jung YK, Tang SC, Sobey CG, ... Arumugam TV, et al. Calsenilin contributes to neuronal cell death in ischemic stroke. Brain Pathology (Zurich, Switzerland). 23: 402-12. PMID 23211047 DOI: 10.1111/bpa.12013  0.8
2013 Manzanero S, Santro T, Arumugam TV. Neuronal oxidative stress in acute ischemic stroke: sources and contribution to cell injury. Neurochemistry International. 62: 712-8. PMID 23201332 DOI: 10.1016/j.neuint.2012.11.009  0.48
2013 Broughton BR, Brait VH, Guida E, Lee S, Arumugam TV, Gardiner-Mann CV, Miller AA, Tang SC, Drummond GR, Sobey CG. Stroke increases g protein-coupled estrogen receptor expression in the brain of male but not female mice. Neuro-Signals. 21: 229-39. PMID 22869326 DOI: 10.1159/000338019  1
2012 Broughton BR, Lim R, Arumugam TV, Drummond GR, Wallace EM, Sobey CG. Post-stroke inflammation and the potential efficacy of novel stem cell therapies: focus on amnion epithelial cells. Frontiers in Cellular Neuroscience. 6: 66. PMID 23335880 DOI: 10.3389/fncel.2012.00066  1
2012 Brait VH, Martin KR, Corlett A, Broughton BRS, Kim HA, Thundyil J, Drummond GR, Arumugam TV, Pritchard MA, Sobey CG. Over-Expression of DSCR1 Protects against Post-Ischemic Neuronal Injury Plos One. 7. PMID 23144708 DOI: 10.1371/journal.pone.0047841  0.8
2012 Dinh QN, Arumugam TV, Young MJ, Drummond GR, Sobey CG, Chrissobolis S. Aldosterone and the mineralocorticoid receptor in the cerebral circulation and stroke. Experimental & Translational Stroke Medicine. 4: 21. PMID 23110876 DOI: 10.1186/2040-7378-4-21  1
2012 Okun E, Barak B, Saada-Madar R, Rothman SM, Griffioen KJ, Roberts N, Castro K, Mughal MR, Pita MA, Stranahan AM, Arumugam TV, Mattson MP. Evidence for a developmental role for TLR4 in learning and memory. Plos One. 7: e47522. PMID 23071817 DOI: 10.1371/journal.pone.0047522  0.8
2012 Coulthard MG, Morgan M, Woodruff TM, Arumugam TV, Taylor SM, Carpenter TC, Lackmann M, Boyd AW. Eph/Ephrin signaling in injury and inflammation. The American Journal of Pathology. 181: 1493-503. PMID 23021982 DOI: 10.1016/j.ajpath.2012.06.043  0.8
2012 Gelderblom M, Weymar A, Bernreuther C, Velden J, Arunachalam P, Steinbach K, Orthey E, Arumugam TV, Leypoldt F, Simova O, Thom V, Friese MA, Prinz I, Hölscher C, Glatzel M, et al. Neutralization of the IL-17 axis diminishes neutrophil invasion and protects from ischemic stroke. Blood. 120: 3793-802. PMID 22976954 DOI: 10.1182/blood-2012-02-412726  0.8
2012 Lee S, Brait VH, Arumugam TV, Evans MA, Kim HA, Widdop RE, Drummond GR, Sobey CG, Jones ES. Neuroprotective effect of an angiotensin receptor type 2 agonist following cerebral ischemia in vitro and in vivo. Experimental & Translational Stroke Medicine. 4: 16. PMID 22920387 DOI: 10.1186/2040-7378-4-16  0.8
2012 Kim HA, Miller AA, Drummond GR, Thrift AG, Arumugam TV, Phan TG, Srikanth VK, Sobey CG. Vascular cognitive impairment and Alzheimer's disease: role of cerebral hypoperfusion and oxidative stress. Naunyn-Schmiedeberg's Archives of Pharmacology. 385: 953-9. PMID 22872171 DOI: 10.1007/s00210-012-0790-7  0.8
2012 Widiapradja A, Vegh V, Lok KZ, Manzanero S, Thundyil J, Gelderblom M, Cheng YL, Pavlovski D, Tang SC, Jo DG, Magnus T, Chan SL, Sobey CG, Reutens D, Basta M, ... ... Arumugam TV, et al. Intravenous immunoglobulin protects neurons against amyloid beta-peptide toxicity and ischemic stroke by attenuating multiple cell death pathways. Journal of Neurochemistry. 122: 321-32. PMID 22494053 DOI: 10.1111/j.1471-4159.2012.07754.x  0.8
2012 Gwon AR, Park JS, Arumugam TV, Kwon YK, Chan SL, Kim SH, Baik SH, Yang S, Yun YK, Choi Y, Kim S, Tang SC, Hyun DH, Cheng A, Dann CE, et al. Oxidative lipid modification of nicastrin enhances amyloidogenic γ-secretase activity in Alzheimer's disease. Aging Cell. 11: 559-68. PMID 22404891 DOI: 10.1111/j.1474-9726.2012.00817.x  0.8
2012 Brait VH, Arumugam TV, Drummond GR, Sobey CG. Importance of T lymphocytes in brain injury, immunodeficiency, and recovery after cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 598-611. PMID 22293986 DOI: 10.1038/jcbfm.2012.6  1
2012 Thundyil J, Pavlovski D, Hsieh YH, Gelderblom M, Magnus T, Fairlie DP, Arumugam TV. C5a receptor (CD88) inhibition improves hypothermia-induced neuroprotection in an in vitro ischemic model. Neuromolecular Medicine. 14: 30-9. PMID 22249919 DOI: 10.1007/s12017-012-8167-0  0.44
2012 Gelderblom M, Leypoldt F, Lewerenz J, Birkenmayer G, Orozco D, Ludewig P, Thundyil J, Arumugam TV, Gerloff C, Tolosa E, Maher P, Magnus T. The flavonoid fisetin attenuates postischemic immune cell infiltration, activation and infarct size after transient cerebral middle artery occlusion in mice. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 835-43. PMID 22234339 DOI: 10.1038/jcbfm.2011.189  0.8
2012 Thundyil J, Pavlovski D, Sobey CG, Arumugam TV. Adiponectin receptor signalling in the brain. British Journal of Pharmacology. 165: 313-27. PMID 21718299 DOI: 10.1111/j.1476-5381.2011.01560.x  1
2011 Manzanero S, Gelderblom M, Magnus T, Arumugam TV. Calorie restriction and stroke. Experimental & Translational Stroke Medicine. 3: 8. PMID 21910904 DOI: 10.1186/2040-7378-3-8  0.48
2011 Wei Z, Chigurupati S, Arumugam TV, Jo DG, Li H, Chan SL. Notch activation enhances the microglia-mediated inflammatory response associated with focal cerebral ischemia. Stroke; a Journal of Cerebral Circulation. 42: 2589-94. PMID 21737799 DOI: 10.1161/STROKEAHA.111.614834  1
2011 Hsieh YH, McCartney K, Moore TA, Thundyil J, Gelderblom M, Manzanero S, Arumugam TV. Intestinal ischemia-reperfusion injury leads to inflammatory changes in the brain. Shock (Augusta, Ga.). 36: 424-30. PMID 21701413 DOI: 10.1097/SHK.0b013e3182295f91  0.48
2011 Arumugam TV, Cheng YL, Choi Y, Choi YH, Yang S, Yun YK, Park JS, Yang DK, Thundyil J, Gelderblom M, Karamyan VT, Tang SC, Chan SL, Magnus T, Sobey CG, et al. Evidence that gamma-secretase-mediated Notch signaling induces neuronal cell death via the nuclear factor-kappaB-Bcl-2-interacting mediator of cell death pathway in ischemic stroke. Molecular Pharmacology. 80: 23-31. PMID 21450930 DOI: 10.1124/mol.111.071076  1
2011 Woodruff TM, Thundyil J, Tang SC, Sobey CG, Taylor SM, Arumugam TV. Pathophysiology, treatment, and animal and cellular models of human ischemic stroke. Molecular Neurodegeneration. 6: 11. PMID 21266064 DOI: 10.1186/1750-1326-6-11  1
2011 Stranahan AM, Arumugam TV, Mattson MP. Lowering corticosterone levels reinstates hippocampal brain-derived neurotropic factor and Trkb expression without influencing deficits in hypothalamic brain-derived neurotropic factor expression in leptin receptor-deficient mice. Neuroendocrinology. 93: 58-64. PMID 21160171 DOI: 10.1159/000322808  0.8
2010 Rashid M, Arumugam TV, Karamyan VT. Association of the novel non-AT1, non-AT2 angiotensin binding site with neuronal cell death. The Journal of Pharmacology and Experimental Therapeutics. 335: 754-61. PMID 20861168 DOI: 10.1124/jpet.110.171439  0.44
2010 Thundyil J, Tang SC, Okun E, Shah K, Karamyan VT, Li YI, Woodruff TM, Taylor SM, Jo DG, Mattson MP, Arumugam TV. Evidence that adiponectin receptor 1 activation exacerbates ischemic neuronal death. Experimental & Translational Stroke Medicine. 2: 15. PMID 20701790 DOI: 10.1186/2040-7378-2-15  0.8
2010 Okun E, Griffioen KJ, Son TG, Lee JH, Roberts NJ, Mughal MR, Hutchison E, Cheng A, Arumugam TV, Lathia JD, van Praag H, Mattson MP. TLR2 activation inhibits embryonic neural progenitor cell proliferation. Journal of Neurochemistry. 114: 462-74. PMID 20456021 DOI: 10.1111/j.1471-4159.2010.06778.x  0.8
2010 Chigurupati S, Mughal MR, Chan SL, Arumugam TV, Baharani A, Tang SC, Yu QS, Holloway HW, Wheeler R, Poosala S, Greig NH, Mattson MP. A synthetic uric acid analog accelerates cutaneous wound healing in mice. Plos One. 5: e10044. PMID 20386608 DOI: 10.1371/journal.pone.0010044  0.8
2010 Stranahan AM, Arumugam TV, Lee K, Mattson MP. Mineralocorticoid receptor activation restores medial perforant path LTP in diabetic rats. Synapse (New York, N.Y.). 64: 528-32. PMID 20196138 DOI: 10.1002/syn.20758  0.8
2010 Arumugam TV, Phillips TM, Cheng A, Morrell CH, Mattson MP, Wan R. Age and energy intake interact to modify cell stress pathways and stroke outcome. Annals of Neurology. 67: 41-52. PMID 20186857 DOI: 10.1002/ana.21798  0.8
2010 Choi YH, Gwon AR, Jeong HY, Park JS, Baik SH, Arumugam TV, Jo DG. Contribution of gamma-secretase to calcium-mediated cell death. Neuroscience Letters. 469: 425-8. PMID 20035833 DOI: 10.1016/j.neulet.2009.12.043  1
2010 Son TG, Camandola S, Arumugam TV, Cutler RG, Telljohann RS, Mughal MR, Moore TA, Luo W, Yu QS, Johnson DA, Johnson JA, Greig NH, Mattson MP. Plumbagin, a novel Nrf2/ARE activator, protects against cerebral ischemia. Journal of Neurochemistry. 112: 1316-26. PMID 20028456 DOI: 10.1111/j.1471-4159.2009.06552.x  0.88
2010 Okun E, Mattson MP, Arumugam TV. Involvement of Fc receptors in disorders of the central nervous system. Neuromolecular Medicine. 12: 164-78. PMID 19844812 DOI: 10.1007/s12017-009-8099-5  0.88
2010 Lathia JD, Chigurupati S, Thundyil J, Selvaraj PK, Mughal MR, Woodruff TM, Chan SL, Karamyan VT, Mattson MP, Arumugam TV. Pivotal role for beta-1 integrin in neurovascular remodelling after ischemic stroke. Experimental Neurology. 221: 107-14. PMID 19837065 DOI: 10.1016/j.expneurol.2009.10.007  0.8
2010 Jo DG, Arumugam TV, Woo HN, Park JS, Tang SC, Mughal M, Hyun DH, Park JH, Choi YH, Gwon AR, Camandola S, Cheng A, Cai H, Song W, Markesbery WR, et al. Evidence that gamma-secretase mediates oxidative stress-induced beta-secretase expression in Alzheimer's disease. Neurobiology of Aging. 31: 917-25. PMID 18687504 DOI: 10.1016/j.neurobiolaging.2008.07.003  0.8
2009 Woo HN, Park JS, Gwon AR, Arumugam TV, Jo DG. Alzheimer's disease and Notch signaling. Biochemical and Biophysical Research Communications. 390: 1093-7. PMID 19853579 DOI: 10.1016/j.bbrc.2009.10.093  1
2009 Chigurupati S, Wei Z, Belal C, Vandermey M, Kyriazis GA, Arumugam TV, Chan SL. The homocysteine-inducible endoplasmic reticulum stress protein counteracts calcium store depletion and induction of CCAAT enhancer-binding protein homologous protein in a neurotoxin model of Parkinson disease. The Journal of Biological Chemistry. 284: 18323-33. PMID 19447887 DOI: 10.1074/jbc.M109.020891  0.44
2009 Gelderblom M, Leypoldt F, Steinbach K, Behrens D, Choe CU, Siler DA, Arumugam TV, Orthey E, Gerloff C, Tolosa E, Magnus T. Temporal and spatial dynamics of cerebral immune cell accumulation in stroke. Stroke; a Journal of Cerebral Circulation. 40: 1849-57. PMID 19265055 DOI: 10.1161/STROKEAHA.108.534503  0.8
2009 Arumugam TV, Okun E, Tang SC, Thundyil J, Taylor SM, Woodruff TM. Toll-like receptors in ischemia-reperfusion injury. Shock (Augusta, Ga.). 32: 4-16. PMID 19008778 DOI: 10.1097/SHK.0b013e318193e333  0.44
2009 Okun E, Griffioen KJ, Lathia JD, Tang SC, Mattson MP, Arumugam TV. Toll-like receptors in neurodegeneration. Brain Research Reviews. 59: 278-92. PMID 18822314 DOI: 10.1016/j.brainresrev.2008.09.001  0.8
2008 Lathia JD, Okun E, Tang SC, Griffioen K, Cheng A, Mughal MR, Laryea G, Selvaraj PK, ffrench-Constant C, Magnus T, Arumugam TV, Mattson MP. Toll-like receptor 3 is a negative regulator of embryonic neural progenitor cell proliferation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 13978-84. PMID 19091986 DOI: 10.1523/JNEUROSCI.2140-08.2008  0.8
2008 Chigurupati S, Son TG, Hyun DH, Lathia JD, Mughal MR, Savell J, Li SC, Nagaraju GP, Chan SL, Arumugam TV, Mattson MP. Lifelong running reduces oxidative stress and degenerative changes in the testes of mice. The Journal of Endocrinology. 199: 333-41. PMID 18701639 DOI: 10.1677/JOE-08-0306  0.88
2008 Tang SC, Lathia JD, Selvaraj PK, Jo DG, Mughal MR, Cheng A, Siler DA, Markesbery WR, Arumugam TV, Mattson MP. Toll-like receptor-4 mediates neuronal apoptosis induced by amyloid beta-peptide and the membrane lipid peroxidation product 4-hydroxynonenal. Experimental Neurology. 213: 114-21. PMID 18586243 DOI: 10.1016/j.expneurol.2008.05.014  0.8
2008 Stranahan AM, Arumugam TV, Cutler RG, Lee K, Egan JM, Mattson MP. Diabetes impairs hippocampal function through glucocorticoid-mediated effects on new and mature neurons. Nature Neuroscience. 11: 309-17. PMID 18278039 DOI: 10.1038/nn2055  0.8
2008 Arumugam TV, Selvaraj PK, Woodruff TM, Mattson MP. Targeting ischemic brain injury with intravenous immunoglobulin. Expert Opinion On Therapeutic Targets. 12: 19-29. PMID 18076367 DOI: 10.1517/14728222.12.1.19  0.8
2007 Chigurupati S, Arumugam TV, Son TG, Lathia JD, Jameel S, Mughal MR, Tang SC, Jo DG, Camandola S, Giunta M, Rakova I, McDonnell N, Miele L, Mattson MP, Poosala S. Involvement of notch signaling in wound healing. Plos One. 2: e1167. PMID 18000539 DOI: 10.1371/journal.pone.0001167  1
2007 Haberman F, Tang SC, Arumugam TV, Hyun DH, Yu QS, Cutler RG, Guo Z, Holloway HW, Greig NH, Mattson MP. Soluble neuroprotective antioxidant uric acid analogs ameliorate ischemic brain injury in mice. Neuromolecular Medicine. 9: 315-23. PMID 17999205 DOI: 10.1007/s12017-007-8010-1  0.88
2007 Arumugam TV, Tang SC, Lathia JD, Cheng A, Mughal MR, Chigurupati S, Magnus T, Chan SL, Jo DG, Ouyang X, Fairlie DP, Granger DN, Vortmeyer A, Basta M, Mattson MP. Intravenous immunoglobulin (IVIG) protects the brain against experimental stroke by preventing complement-mediated neuronal cell death. Proceedings of the National Academy of Sciences of the United States of America. 104: 14104-9. PMID 17715065 DOI: 10.1073/pnas.0700506104  0.8
2007 Tang SC, Arumugam TV, Xu X, Cheng A, Mughal MR, Jo DG, Lathia JD, Siler DA, Chigurupati S, Ouyang X, Magnus T, Camandola S, Mattson MP. Pivotal role for neuronal Toll-like receptors in ischemic brain injury and functional deficits. Proceedings of the National Academy of Sciences of the United States of America. 104: 13798-803. PMID 17693552 DOI: 10.1073/pnas.0702553104  0.8
2007 Okun E, Arumugam TV, Tang SC, Gleichmann M, Albeck M, Sredni B, Mattson MP. The organotellurium compound ammonium trichloro(dioxoethylene-0,0') tellurate enhances neuronal survival and improves functional outcome in an ischemic stroke model in mice. Journal of Neurochemistry. 102: 1232-41. PMID 17542809 DOI: 10.1111/j.1471-4159.2007.04615.x  0.88
2007 Magnus T, Coksaygan T, Korn T, Xue H, Arumugam TV, Mughal MR, Eckley DM, Tang SC, Detolla L, Rao MS, Cassiani-Ingoni R, Mattson MP. Evidence that nucleocytoplasmic Olig2 translocation mediates brain-injury-induced differentiation of glial precursors to astrocytes. Journal of Neuroscience Research. 85: 2126-37. PMID 17510983 DOI: 10.1002/jnr.21368  0.88
2007 Cheng A, Arumugam TV, Liu D, Khatri RG, Mustafa K, Kwak S, Ling HP, Gonzales C, Xin O, Jo DG, Guo Z, Mark RJ, Mattson MP. Pancortin-2 interacts with WAVE1 and Bcl-xL in a mitochondria-associated protein complex that mediates ischemic neuronal death. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 1519-28. PMID 17301160 DOI: 10.1523/JNEUROSCI.5154-06.2007  0.8
2007 Tang SC, Arumugam TV, Cutler RG, Jo DG, Magnus T, Chan SL, Mughal MR, Telljohann RS, Nassar M, Ouyang X, Calderan A, Ruzza P, Guiotto A, Mattson MP. Neuroprotective actions of a histidine analogue in models of ischemic stroke. Journal of Neurochemistry. 101: 729-36. PMID 17254011 DOI: 10.1111/j.1471-4159.2006.04412.x  1
2006 Arumugam TV, Magnus T, Woodruff TM, Proctor LM, Shiels IA, Taylor SM. Complement mediators in ischemia-reperfusion injury. Clinica Chimica Acta; International Journal of Clinical Chemistry. 374: 33-45. PMID 16872589 DOI: 10.1016/j.cca.2006.06.010  0.8
2006 Arumugam TV, Gleichmann M, Tang SC, Mattson MP. Hormesis/preconditioning mechanisms, the nervous system and aging. Ageing Research Reviews. 5: 165-78. PMID 16682262 DOI: 10.1016/j.arr.2006.03.003  0.88
2006 Arumugam TV, Chan SL, Jo DG, Yilmaz G, Tang SC, Cheng A, Gleichmann M, Okun E, Dixit VD, Chigurupati S, Mughal MR, Ouyang X, Miele L, Magnus T, Poosala S, et al. Gamma secretase-mediated Notch signaling worsens brain damage and functional outcome in ischemic stroke. Nature Medicine. 12: 621-3. PMID 16680150 DOI: 10.1038/nm1403  0.8
2005 Arumugam TV, Granger DN, Mattson MP. Stroke and T-cells. Neuromolecular Medicine. 7: 229-42. PMID 16247183 DOI: 10.1385/NMM:7:3:229  0.88
2005 Woodruff TM, Arumugam TV, Shiels IA, Newman ML, Ross PA, Reid RC, Fairlie DP, Taylor SM. A potent and selective inhibitor of group IIa secretory phospholipase A2 protects rats from TNBS-induced colitis. International Immunopharmacology. 5: 883-92. PMID 15778124 DOI: 10.1016/j.intimp.2005.01.003  0.8
2004 Proctor LM, Arumugam TV, Shiels I, Reid RC, Fairlie DP, Taylor SM. Comparative anti-inflammatory activities of antagonists to C3a and C5a receptors in a rat model of intestinal ischaemia/reperfusion injury. British Journal of Pharmacology. 142: 756-64. PMID 15159277 DOI: 10.1038/sj.bjp.0705819  0.8
2004 Arumugam TV, Woodruff TM, Stocks SZ, Proctor LM, Pollitt S, Shiels IA, Reid RC, Fairlie DP, Taylor SM. Protective effect of a human C5a receptor antagonist against hepatic ischaemia-reperfusion injury in rats. Journal of Hepatology. 40: 934-41. PMID 15158333 DOI: 10.1016/j.jhep.2004.02.017  0.8
2004 Arumugam TV, Shiels IA, Woodruff TM, Granger DN, Taylor SM. The role of the complement system in ischemia-reperfusion injury. Shock (Augusta, Ga.). 21: 401-9. PMID 15087815  0.44
2004 Woodruff TM, Arumugam TV, Shiels IA, Reid RC, Fairlie DP, Taylor SM. Protective effects of a potent C5a receptor antagonist on experimental acute limb ischemia-reperfusion in rats. The Journal of Surgical Research. 116: 81-90. PMID 14732352 DOI: 10.1016/j.jss.2003.04.001  0.8
2003 Woodruff TM, Arumugam TV, Shiels IA, Reid RC, Fairlie DP, Taylor SM. A potent human C5a receptor antagonist protects against disease pathology in a rat model of inflammatory bowel disease. Journal of Immunology (Baltimore, Md. : 1950). 171: 5514-20. PMID 14607958  0.8
2003 Arumugam TV, Arnold N, Proctor LM, Newman M, Reid RC, Hansford KA, Fairlie DP, Shiels IA, Taylor SM. Comparative protection against rat intestinal reperfusion injury by a new inhibitor of sPLA2, COX-1 and COX-2 selective inhibitors, and an LTC4 receptor antagonist. British Journal of Pharmacology. 140: 71-80. PMID 12967936 DOI: 10.1038/sj.bjp.0705402  0.8
2002 Arumugam TV, Shiels IA, Margolin SB, Taylor SM, Brown L. Pirfenidone attenuates ischaemia-reperfusion injury in the rat small intestine. Clinical and Experimental Pharmacology & Physiology. 29: 996-1000. PMID 12366391 DOI: 10.1046/j.1440-1681.2002.03766.x  0.8
2002 Arumugam TV, Shiels IA, Woodruff TM, Reid RC, Fairlie DP, Taylor SM. Protective effect of a new C5a receptor antagonist against ischemia-reperfusion injury in the rat small intestine. The Journal of Surgical Research. 103: 260-7. PMID 11922743 DOI: 10.1006/jsre.2002.6369  0.8
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