| Year | Citation | Score | |||
|---|---|---|---|---|---|
| 2023 | Brady EB, McQuillan M, Medeiros AT, Bubacco L, Sousa R, Lafer EM, Morgan JR. Hsc70 rescues the synaptic vesicle trafficking defects caused by α-synuclein dimers. Micropublication Biology. 2023. PMID 36938331 DOI: 10.17912/micropub.biology.000737 | 0.562 | |||
| 2020 | Filippini A, Mutti V, Faustini G, Longhena F, Ramazzina I, Rizzi F, Kaganovich A, Roosen DA, Landeck N, Duffy M, Tessari I, Bono F, Fiorentini C, Greggio E, Bubacco L, et al. Extracellular clusterin limits the uptake of α-synuclein fibrils by murine and human astrocytes. Glia. PMID 33045109 DOI: 10.1002/glia.23920 | 0.516 | |||
| 2020 | Sulzer D, Antonini A, Leta V, Nordvig A, Smeyne RJ, Goldman JE, Al-Dalahmah O, Zecca L, Sette A, Bubacco L, Meucci O, Moro E, Harms AS, Xu Y, Fahn S, et al. COVID-19 and possible links with Parkinson's disease and parkinsonism: from bench to bedside. Npj Parkinson's Disease. 6: 18. PMID 32885037 DOI: 10.1038/S41531-020-00123-0 | 0.316 | |||
| 2020 | Moretti P, Mariani P, Ortore MG, Plotegher N, Bubacco L, Beltramini M, Spinozzi F. Comprehensive Structural and Thermodynamic Analysis of Pre-Fibrillar WT α-Synuclein and its G51D, E46K and A53T Mutants by a Combination of Small-Angle X-Ray Scattering and Variational Bayesian Weighting. Journal of Chemical Information and Modeling. PMID 32866007 DOI: 10.1021/Acs.Jcim.0C00807 | 0.349 | |||
| 2020 | Munari F, Barracchia CG, Parolini F, Tira R, Bubacco L, Assfalg M, D'Onofrio M. Semisynthetic Modification of Tau Protein with Di-Ubiquitin Chains for Aggregation Studies. International Journal of Molecular Sciences. 21. PMID 32575755 DOI: 10.3390/Ijms21124400 | 0.355 | |||
| 2020 | Barracchia CG, Tira R, Parolini F, Munari F, Bubacco L, Spyroulias GA, D'Onofrio M, Assfalg M. Unsaturated Fatty Acid-Induced Conformational Transitions and Aggregation of the Repeat Domain of Tau. Molecules (Basel, Switzerland). 25. PMID 32545360 DOI: 10.3390/Molecules25112716 | 0.302 | |||
| 2020 | Antonini A, Bravi D, Sandre M, Bubacco L. Immunization therapies for Parkinson's disease: state of the art and considerations for future clinical trials. Expert Opinion On Investigational Drugs. PMID 32419521 DOI: 10.1080/13543784.2020.1771693 | 0.346 | |||
| 2020 | Bellucci A, Bubacco L, Longhena F, Parrella E, Faustini G, Porrini V, Bono F, Missale C, Pizzi M. Nuclear Factor-κB Dysregulation and α-Synuclein Pathology: Critical Interplay in the Pathogenesis of Parkinson's Disease. Frontiers in Aging Neuroscience. 12: 68. PMID 32265684 DOI: 10.3389/Fnagi.2020.00068 | 0.394 | |||
| 2020 | Munari F, Barracchia CG, Franchin C, Parolini F, Capaldi S, Romeo A, Bubacco L, Assfalg M, Arrigoni G, D'Onofrio M. Semisynthetic and enzyme-mediated conjugate preparations illuminate the ubiquitination-dependent aggregation of protein tau. Angewandte Chemie (International Ed. in English). PMID 32022419 DOI: 10.1002/Anie.201916756 | 0.355 | |||
| 2019 | Masato A, Plotegher N, Boassa D, Bubacco L. Impaired dopamine metabolism in Parkinson's disease pathogenesis. Molecular Neurodegeneration. 14: 35. PMID 31488222 DOI: 10.1186/S13024-019-0332-6 | 0.393 | |||
| 2019 | Capucciati A, Galliano M, Bubacco L, Zecca L, Casella L, Monzani E, Nicolis S. Neuronal proteins as targets of 3-hydroxykynurenine: Implications in neurodegenerative diseases. Acs Chemical Neuroscience. PMID 31298828 DOI: 10.1021/Acschemneuro.9B00265 | 0.381 | |||
| 2019 | Biosa A, De Lazzari F, Masato A, Filograna R, Plotegher N, Beltramini M, Bubacco L, Bisaglia M. Superoxide Dismutases SOD1 and SOD2 Rescue the Toxic Effect of Dopamine-Derived Products in Human SH-SY5Y Neuroblastoma Cells. Neurotoxicity Research. PMID 31228093 DOI: 10.1007/S12640-019-00078-Y | 0.362 | |||
| 2019 | Russo I, Kaganovich A, Ding J, Landeck N, Mamais A, Varanita T, Biosa A, Tessari I, Bubacco L, Greggio E, Cookson MR. Transcriptase analysis of LRRK2 knock-out microglia cells reveals alterations of inflammatory- and oxidative stress-related pathways upon treatment with α-synuclein fibrils. Neurobiology of Disease. PMID 31102768 DOI: 10.1016/J.Nbd.2019.05.012 | 0.551 | |||
| 2019 | Plotegher N, Bubacco L, Greggio E, Civiero L. Ceramides in Parkinson's Disease: From Recent Evidence to New Hypotheses. Frontiers in Neuroscience. 13: 330. PMID 31001082 DOI: 10.3389/Fnins.2019.00330 | 0.339 | |||
| 2018 | Russo I, Di Benedetto G, Kaganovich A, Ding J, Mercatelli D, Morari M, Cookson MR, Bubacco L, Greggio E. Leucine-rich repeat kinase 2 controls protein kinase A activation state through phosphodiesterase 4. Journal of Neuroinflammation. 15: 297. PMID 30368241 DOI: 10.1186/S12974-018-1337-8 | 0.618 | |||
| 2018 | De Lazzari F, Bubacco L, Whitworth AJ, Bisaglia M. Superoxide Radical Dismutation as New Therapeutic Strategy in Parkinson's Disease. Aging and Disease. 9: 716-728. PMID 30090659 DOI: 10.14336/Ad.2017.1018 | 0.37 | |||
| 2018 | Faustini G, Longhena F, Varanita T, Bubacco L, Pizzi M, Missale C, Benfenati F, Björklund A, Spano P, Bellucci A. Synapsin III deficiency hampers α-synuclein aggregation, striatal synaptic damage and nigral cell loss in an AAV-based mouse model of Parkinson's disease. Acta Neuropathologica. PMID 30046897 DOI: 10.1007/S00401-018-1892-1 | 0.407 | |||
| 2018 | Biosa A, Arduini I, Soriano ME, Giorgio V, Bernardi P, Bisaglia M, Bubacco L. Dopamine oxidation products as mitochondrial endotoxins, a potential molecular mechanism for preferential neurodegeneration in Parkinson Disease. Acs Chemical Neuroscience. PMID 29906101 DOI: 10.1021/Acschemneuro.8B00276 | 0.344 | |||
| 2018 | Medeiros AT, Bubacco L, Morgan JR. Impacts of increased α-synuclein on clathrin-mediated endocytosis at synapses: implications for neurodegenerative diseases. Neural Regeneration Research. 13: 647-648. PMID 29722314 DOI: 10.4103/1673-5374.230289 | 0.595 | |||
| 2018 | Biosa A, Outeiro TF, Bubacco L, Bisaglia M. Diabetes Mellitus as a Risk Factor for Parkinson's Disease: a Molecular Point of View. Molecular Neurobiology. PMID 29594935 DOI: 10.1007/S12035-018-1025-9 | 0.362 | |||
| 2018 | Biosa A, Sanchez-Martinez A, Filograna R, Terriente-Felix A, Alam SM, Beltramini M, Bubacco L, Bisaglia M, Whitworth AJ. Superoxide dismutating molecules rescue the toxic effects of PINK1 and parkin loss. Human Molecular Genetics. PMID 29529199 DOI: 10.1093/Hmg/Ddy069 | 0.36 | |||
| 2018 | Longhena F, Faustini G, Varanita T, Zaltieri M, Porrini V, Tessari I, Poliani PL, Missale C, Borroni B, Padovani A, Bubacco L, Pizzi M, Spano P, Bellucci A. Synapsin III is a key component of α-synuclein fibrils in Lewy bodies of PD brains. Brain Pathology (Zurich, Switzerland). PMID 29330884 DOI: 10.1111/Bpa.12587 | 0.378 | |||
| 2018 | De Lazzari F, Frighetto G, Stramazzo M, Bubacco L, Whitworth A, Malacrida S, Zordan MA, Megighian A, Sandrelli F, Bisaglia M. The involvement of the anti-oxidant protein DJ-1 in SOD1 maturation pathway: implications for neurobehavioral deficits in Drosophila Melanogaster Free Radical Biology and Medicine. 120: S75. DOI: 10.1016/J.Freeradbiomed.2018.04.249 | 0.33 | |||
| 2017 | Medeiros AT, Soll LG, Tessari I, Bubacco L, Morgan JR. α-Synuclein Dimers Impair Vesicle Fission during Clathrin-Mediated Synaptic Vesicle Recycling. Frontiers in Cellular Neuroscience. 11: 388. PMID 29321725 DOI: 10.3389/Fncel.2017.00388 | 0.619 | |||
| 2017 | Civiero L, Cogo S, Kiekens A, Morganti C, Tessari I, Lobbestael E, Baekelandt V, Taymans JM, Chartier-Harlin MC, Franchin C, Arrigoni G, Lewis PA, Piccoli G, Bubacco L, Cookson MR, et al. PAK6 Phosphorylates 14-3-3γ to Regulate Steady State Phosphorylation of LRRK2. Frontiers in Molecular Neuroscience. 10: 417. PMID 29311810 DOI: 10.3389/Fnmol.2017.00417 | 0.559 | |||
| 2017 | Piccirilli F, Plotegher N, Ortore MG, Tessari I, Brucale M, Spinozzi F, Beltramini M, Mariani P, Militello V, Lupi S, Perucchi A, Bubacco L. High-Pressure-Driven Reversible Dissociation of α-Synuclein Fibrils Reveals Structural Hierarchy. Biophysical Journal. 113: 1685-1696. PMID 29045863 DOI: 10.1016/J.Bpj.2017.08.042 | 0.336 | |||
| 2017 | Biosa A, Sandrelli F, Beltramini M, Greggio E, Bubacco L, Bisaglia M. Recent findings on the physiological function of DJ-1: Beyond Parkinson's disease. Neurobiology of Disease. 108: 65-72. PMID 28823929 DOI: 10.1016/J.Nbd.2017.08.005 | 0.35 | |||
| 2017 | Piccirilli F, Plotegher N, Spinozzi F, Bubacco L, Mariani P, Beltramini M, Tessari I, Militello V, Perucchi A, Amenitsch H, Baldassarri E, Steinhart M, Lupi S, Ortore MG. Pressure effects on α-synuclein amyloid fibrils: An experimental investigation on their dissociation and reversible nature. Archives of Biochemistry and Biophysics. 627: 46-55. PMID 28624352 DOI: 10.1016/J.Abb.2017.06.007 | 0.349 | |||
| 2017 | Ramírez MB, Ordóñez AJL, Fdez E, Madero-Pérez J, Gonnelli A, Drouyer M, Chartier-Harlin MC, Taymans JM, Bubacco L, Greggio E, Hilfiker S. GTP binding regulates cellular localization of Parkinson's disease-associated LRRK2. Human Molecular Genetics. 26: 2747-2767. PMID 28453723 DOI: 10.1093/Hmg/Ddx161 | 0.374 | |||
| 2017 | Civiero L, Russo I, Bubacco L, Greggio E. Molecular Insights and Functional Implication of LRRK2 Dimerization. Advances in Neurobiology. 14: 107-121. PMID 28353281 DOI: 10.1007/978-3-319-49969-7_6 | 0.363 | |||
| 2017 | Longo F, Mercatelli D, Novello S, Arcuri L, Brugnoli A, Vincenzi F, Russo I, Berti G, Mabrouk OS, Kennedy RT, Shimshek DR, Varani K, Bubacco L, Greggio E, Morari M. Age-dependent dopamine transporter dysfunction and Serine129 phospho-α-synuclein overload in G2019S LRRK2 mice. Acta Neuropathologica Communications. 5: 22. PMID 28292328 DOI: 10.1186/S40478-017-0426-8 | 0.531 | |||
| 2017 | Ferrari E, Capucciati A, Prada I, Zucca FA, D'Arrigo G, Pontiroli D, Bridelli MG, Sturini M, Bubacco L, Monzani E, Verderio C, Zecca L, Casella L. Synthesis, Structure Characterization, and Evaluation in Microglia Cultures of Neuromelanin Analogues Suitable for Modeling Parkinson's Disease. Acs Chemical Neuroscience. 8: 501-512. PMID 28292181 DOI: 10.1021/Acschemneuro.6B00231 | 0.364 | |||
| 2017 | Greggio E, Bubacco L, Russo I. Cross-talk between LRRK2 and PKA: implication for Parkinson's disease? Biochemical Society Transactions. 45: 261-267. PMID 28202680 DOI: 10.1042/Bst20160396 | 0.389 | |||
| 2017 | Plotegher N, Berti G, Ferrari E, Tessari I, Zanetti M, Lunelli L, Greggio E, Bisaglia M, Veronesi M, Girotto S, Dalla Serra M, Perego C, Casella L, Bubacco L. DOPAL derived alpha-synuclein oligomers impair synaptic vesicles physiological function. Scientific Reports. 7: 40699. PMID 28084443 DOI: 10.1038/Srep40699 | 0.36 | |||
| 2016 | Cartelli D, Aliverti A, Barbiroli A, Santambrogio C, Ragg EM, Casagrande FV, Cantele F, Beltramone S, Marangon J, De Gregorio C, Pandini V, Emanuele M, Chieregatti E, Pieraccini S, Holmqvist S, ... Bubacco L, et al. α-Synuclein is a Novel Microtubule Dynamase. Scientific Reports. 6: 33289. PMID 27628239 DOI: 10.1038/Srep33289 | 0.373 | |||
| 2016 | Ferrazza R, Cogo S, Melrose H, Bubacco L, Greggio E, Guella G, Civiero L, Plotegher N. LRRK2 deficiency impacts ceramide metabolism in brain. Biochemical and Biophysical Research Communications. 478: 1141-6. PMID 27539321 DOI: 10.1016/J.Bbrc.2016.08.082 | 0.362 | |||
| 2016 | Filograna R, Godena VK, Sanchez-Martinez A, Ferrari E, Casella L, Beltramini M, Bubacco L, Whitworth AJ, Bisaglia M. SOD-mimetic M40403 is protective in cell and fly models of paraquat toxicity: Implications for Parkinson disease. The Journal of Biological Chemistry. PMID 26953346 DOI: 10.1074/Jbc.M115.708057 | 0.341 | |||
| 2016 | Belluzzi E, Gonnelli A, Cirnaru MD, Marte A, Plotegher N, Russo I, Civiero L, Cogo S, Carrion MP, Franchin C, Arrigoni G, Beltramini M, Bubacco L, Onofri F, Piccoli G, et al. LRRK2 phosphorylates pre-synaptic N-ethylmaleimide sensitive fusion (NSF) protein enhancing its ATPase activity and SNARE complex disassembling rate. Molecular Neurodegeneration. 11: 1. PMID 26758690 DOI: 10.1186/S13024-015-0066-Z | 0.356 | |||
| 2016 | Plotegher N, Bubacco L. Lysines, Achilles' heel in alpha-synuclein conversion to a deadly neuronal endotoxin. Ageing Research Reviews. 26: 62-71. PMID 26690800 DOI: 10.1016/J.Arr.2015.12.002 | 0.356 | |||
| 2016 | Filograna R, Beltramini M, Bubacco L, Bisaglia M. Anti-Oxidants in Parkinson's Disease Therapy: A Critical Point of View. Current Neuropharmacology. 14: 260-71. PMID 26517052 DOI: 10.2174/1570159X13666151030102718 | 0.345 | |||
| 2015 | Russo I, Berti G, Plotegher N, Bernardo G, Filograna R, Bubacco L, Greggio E. Leucine-rich repeat kinase 2 positively regulates inflammation and down-regulates NF-κB p50 signaling in cultured microglia cells. Journal of Neuroinflammation. 12: 230. PMID 26646749 DOI: 10.1186/S12974-015-0449-7 | 0.365 | |||
| 2015 | Civiero L, Cirnaru MD, Beilina A, Rodella U, Russo I, Belluzzi E, Lobbestael E, Reyniers L, Hondhamuni G, Lewis PA, Van den Haute C, Baekelandt V, Bandopadhyay R, Bubacco L, Piccoli G, et al. Leucine-rich repeat kinase 2 interacts with p21-activated kinase 6 to control neurite complexity in mammalian brain. Journal of Neurochemistry. PMID 26375402 DOI: 10.1111/Jnc.13369 | 0.55 | |||
| 2015 | Plotegher N, Stringari C, Jahid S, Veronesi M, Girotto S, Gratton E, Bubacco L. NADH fluorescence lifetime is an endogenous reporter of α-synuclein aggregation in live cells. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 2484-94. PMID 25713058 DOI: 10.1096/Fj.14-260281 | 0.346 | |||
| 2015 | Sivanesam K, Byrne A, Bisaglia M, Bubacco L, Andersen N. Binding Interactions of Agents That Alter α-Synuclein Aggregation. Rsc Advances. 5: 11577-11590. PMID 25705374 DOI: 10.1039/C5Ra00325C | 0.331 | |||
| 2015 | Ruzza P, Gazziero M, Marchi MD, Massalongo G, Marchiani A, Autiero I, Tessari I, Bubacco L, Calderan A. Peptides as modulators of α-synuclein aggregation. Protein and Peptide Letters. 22: 354-61. PMID 25666040 DOI: 10.2174/0929866522666150209142649 | 0.365 | |||
| 2015 | De Ricco R, Valensin D, Dell'Acqua S, Casella L, Gaggelli E, Valensin G, Bubacco L, Mangani S. Differences in the binding of copper(I) to α- and β-synuclein. Inorganic Chemistry. 54: 265-72. PMID 25495902 DOI: 10.1021/Ic502407W | 0.42 | |||
| 2014 | Vicario M, Zagari A, Granata V, Munari F, Mammi S, Bubacco L, Skaper SD, Negro A. A novel prion protein-tyrosine hydroxylase interaction. Cns & Neurological Disorders Drug Targets. 13: 896-908. PMID 25012618 DOI: 10.2174/1871527313666140711092955 | 0.342 | |||
| 2014 | Cirnaru MD, Marte A, Belluzzi E, Russo I, Gabrielli M, Longo F, Arcuri L, Murru L, Bubacco L, Matteoli M, Fedele E, Sala C, Passafaro M, Morari M, Greggio E, et al. LRRK2 kinase activity regulates synaptic vesicle trafficking and neurotransmitter release through modulation of LRRK2 macro-molecular complex. Frontiers in Molecular Neuroscience. 7: 49. PMID 24904275 DOI: 10.3389/Fnmol.2014.00049 | 0.543 | |||
| 2014 | Plotegher N, Kumar D, Tessari I, Brucale M, Munari F, Tosatto L, Belluzzi E, Greggio E, Bisaglia M, Capaldi S, Aioanei D, Mammi S, Monaco HL, Samo B, Bubacco L. The chaperone-like protein 14-3-3η interacts with human α-synuclein aggregation intermediates rerouting the amyloidogenic pathway and reducing α-synuclein cellular toxicity. Human Molecular Genetics. 23: 5615-29. PMID 24895406 DOI: 10.1093/Hmg/Ddu275 | 0.393 | |||
| 2014 | Russo I, Bubacco L, Greggio E. LRRK2 and neuroinflammation: partners in crime in Parkinson's disease? Journal of Neuroinflammation. 11: 52. PMID 24655756 DOI: 10.1186/1742-2094-11-52 | 0.38 | |||
| 2014 | Girotto S, Cendron L, Bisaglia M, Tessari I, Mammi S, Zanotti G, Bubacco L. DJ-1 is a copper chaperone acting on SOD1 activation. The Journal of Biological Chemistry. 289: 10887-99. PMID 24567322 DOI: 10.1074/Jbc.M113.535112 | 0.377 | |||
| 2014 | Plotegher N, Gratton E, Bubacco L. Number and Brightness analysis of alpha-synuclein oligomerization and the associated mitochondrial morphology alterations in live cells Biochimica Et Biophysica Acta - General Subjects. 1840: 2014-2024. PMID 24561157 DOI: 10.1016/J.Bbagen.2014.02.013 | 0.34 | |||
| 2014 | Plotegher N, Greggio E, Bisaglia M, Bubacco L. Biophysical groundwork as a hinge to unravel the biology of α-synuclein aggregation and toxicity. Quarterly Reviews of Biophysics. 47: 1-48. PMID 24443929 DOI: 10.1017/S0033583513000097 | 0.366 | |||
| 2014 | Bisaglia M, Filograna R, Beltramini M, Bubacco L. Are dopamine derivatives implicated in the pathogenesis of Parkinson's disease? Ageing Research Reviews. 13: 107-14. PMID 24389159 DOI: 10.1016/J.Arr.2013.12.009 | 0.395 | |||
| 2014 | Ruzza P, Siligardi G, Hussain R, Marchiani A, Islami M, Bubacco L, Delogu G, Fabbri D, Dettori MA, Sechi M, Pala N, Spissu Y, Migheli R, Serra PA, Sechi G. Ceftriaxone blocks the polymerization of α-synuclein and exerts neuroprotective effects in vitro Acs Chemical Neuroscience. 5: 30-38. PMID 24099687 DOI: 10.1021/Cn400149K | 0.41 | |||
| 2014 | Plotegher N, Stringari C, Jahid S, Gratton E, Bubacco L. NADH is an Endogenous Reporter for Alpha-Synuclein Aggregation in Live Cells Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.392 | 0.333 | |||
| 2013 | Fecchio C, De Franceschi G, Relini A, Greggio E, Dalla Serra M, Bubacco L, Polverino de Laureto P. α-Synuclein oligomers induced by docosahexaenoic acid affect membrane integrity. Plos One. 8: e82732. PMID 24312431 DOI: 10.1371/Journal.Pone.0082732 | 0.341 | |||
| 2013 | Marchiani A, Mammi S, Siligardi G, Hussain R, Tessari I, Bubacco L, Delogu G, Fabbri D, Dettori MA, Sanna D, Dedola S, Serra PA, Ruzza P. Small molecules interacting with α-synuclein: antiaggregating and cytoprotective properties. Amino Acids. 45: 327-38. PMID 23645386 DOI: 10.1007/S00726-013-1503-3 | 0.356 | |||
| 2013 | Bisaglia M, Greggio E, Beltramini M, Bubacco L. Dysfunction of dopamine homeostasis: clues in the hunt for novel Parkinson's disease therapies. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 2101-10. PMID 23463698 DOI: 10.1096/Fj.12-226852 | 0.357 | |||
| 2013 | Codolo G, Plotegher N, Pozzobon T, Brucale M, Tessari I, Bubacco L, de Bernard M. Triggering of inflammasome by aggregated α-synuclein, an inflammatory response in synucleinopathies. Plos One. 8: e55375. PMID 23383169 DOI: 10.1371/Journal.Pone.0055375 | 0.361 | |||
| 2013 | Camponeschi F, Valensin D, Tessari I, Bubacco L, Dell'Acqua S, Casella L, Monzani E, Gaggelli E, Valensin G. Copper(I)-α-synuclein interaction: structural description of two independent and competing metal binding sites. Inorganic Chemistry. 52: 1358-67. PMID 23343468 DOI: 10.1021/Ic302050M | 0.35 | |||
| 2013 | Biosa A, Trancikova A, Civiero L, Glauser L, Bubacco L, Greggio E, Moore DJ. GTPase activity regulates kinase activity and cellular phenotypes of Parkinson's disease-associated LRRK2. Human Molecular Genetics. 22: 1140-56. PMID 23241358 DOI: 10.1093/Hmg/Dds522 | 0.349 | |||
| 2012 | Pivato M, De Franceschi G, Tosatto L, Frare E, Kumar D, Aioanei D, Brucale M, Tessari I, Bisaglia M, Samori B, de Laureto PP, Bubacco L. Covalent α-synuclein dimers: chemico-physical and aggregation properties. Plos One. 7: e50027. PMID 23272053 DOI: 10.1371/Journal.Pone.0050027 | 0.374 | |||
| 2012 | Civiero L, Bubacco L. Human leucine-rich repeat kinase 1 and 2: intersecting or unrelated functions? Biochemical Society Transactions. 40: 1095-101. PMID 22988872 DOI: 10.1042/Bst20120123 | 0.37 | |||
| 2012 | Civiero L, Vancraenenbroeck R, Belluzzi E, Beilina A, Lobbestael E, Reyniers L, Gao F, Micetic I, De Maeyer M, Bubacco L, Baekelandt V, Cookson MR, Greggio E, Taymans JM. Biochemical characterization of highly purified leucine-rich repeat kinases 1 and 2 demonstrates formation of homodimers. Plos One. 7: e43472. PMID 22952686 DOI: 10.1371/Journal.Pone.0043472 | 0.573 | |||
| 2012 | Tosatto L, Andrighetti AO, Plotegher N, Antonini V, Tessari I, Ricci L, Bubacco L, Dalla Serra M. Alpha-synuclein pore forming activity upon membrane association Biochimica Et Biophysica Acta - Biomembranes. 1818: 2876-2883. PMID 22820150 DOI: 10.1016/J.Bbamem.2012.07.007 | 0.37 | |||
| 2012 | Belluzzi E, Bisaglia M, Lazzarini E, Tabares LC, Beltramini M, Bubacco L. Human SOD2 modification by dopamine quinones affects enzymatic activity by promoting its aggregation: possible implications for Parkinson's disease. Plos One. 7: e38026. PMID 22723845 DOI: 10.1371/Journal.Pone.0038026 | 0.375 | |||
| 2012 | Greggio E, Civiero L, Bisaglia M, Bubacco L. Parkinson's disease and immune system: is the culprit LRRKing in the periphery? Journal of Neuroinflammation. 9: 94. PMID 22594666 DOI: 10.1186/1742-2094-9-94 | 0.33 | |||
| 2012 | Girotto S, Sturlese M, Bellanda M, Tessari I, Cappellini R, Bisaglia M, Bubacco L, Mammi S. Dopamine-derived quinones affect the structure of the redox sensor DJ-1 through modifications at Cys-106 and Cys-53. The Journal of Biological Chemistry. 287: 18738-49. PMID 22431735 DOI: 10.1074/Jbc.M111.311589 | 0.374 | |||
| 2012 | Civiero L, Lobbestael E, Gao F, Beilina A, Reyniers L, Vancraenenbroeck R, Belluzzi E, Micetic I, Maeyer MD, Bubacco L, Baekelandt V, Cookson M, Taymans J, Greggio E. Electron microscopy analysis of purified LRRK1 and LRRK2 demonstrates formation of dimers F1000research. 3. DOI: 10.7490/F1000Research.1090051.1 | 0.476 | |||
| 2011 | Huggins KN, Bisaglia M, Bubacco L, Tatarek-Nossol M, Kapurniotu A, Andersen NH. Designed hairpin peptides interfere with amyloidogenesis pathways: fibril formation and cytotoxicity inhibition, interception of the preamyloid state. Biochemistry. 50: 8202-12. PMID 21848289 DOI: 10.1021/Bi200760H | 0.331 | |||
| 2011 | De Franceschi G, Frare E, Pivato M, Relini A, Penco A, Greggio E, Bubacco L, Fontana A, de Laureto PP. Structural and morphological characterization of aggregated species of α-synuclein induced by docosahexaenoic acid. The Journal of Biological Chemistry. 286: 22262-74. PMID 21527634 DOI: 10.1074/Jbc.M110.202937 | 0.404 | |||
| 2011 | Greggio E, Bisaglia M, Civiero L, Bubacco L. Leucine-rich repeat kinase 2 and alpha-synuclein: intersecting pathways in the pathogenesis of Parkinson's disease? Molecular Neurodegeneration. 6: 6. PMID 21244648 DOI: 10.1186/1750-1326-6-6 | 0.427 | |||
| 2010 | Bortolus M, Bisaglia M, Zoleo A, Fittipaldi M, Benfatto M, Bubacco L, Maniero AL. Structural characterization of a high affinity mononuclear site in the copper(II)-α-synuclein complex. Journal of the American Chemical Society. 132: 18057-66. PMID 21141829 DOI: 10.1021/Ja103338N | 0.352 | |||
| 2010 | Bisaglia M, Soriano ME, Arduini I, Mammi S, Bubacco L. Molecular characterization of dopamine-derived quinones reactivity toward NADH and glutathione: implications for mitochondrial dysfunction in Parkinson disease. Biochimica Et Biophysica Acta. 1802: 699-706. PMID 20600874 DOI: 10.1016/J.Bbadis.2010.06.006 | 0.356 | |||
| 2010 | Bisaglia M, Greggio E, Maric D, Miller DW, Cookson MR, Bubacco L. Alpha-synuclein overexpression increases dopamine toxicity in BE2-M17 cells. Bmc Neuroscience. 11: 41. PMID 20334701 DOI: 10.1186/1471-2202-11-41 | 0.557 | |||
| 2010 | Bisaglia M, Tosatto L, Munari F, Tessari I, de Laureto PP, Mammi S, Bubacco L. Dopamine quinones interact with α-synuclein to form unstructured adducts Biochemical and Biophysical Research Communications. 394: 424-428. PMID 20226175 DOI: 10.1016/J.Bbrc.2010.03.044 | 0.397 | |||
| 2010 | Tosatto L, Plotegher N, Tessari I, Bisaglia M, Bubacco L, Serra MD. Insights on Channel-Like Activity of Membrane Bound Alpha-Synuclein Biophysical Journal. 98: 1-9. DOI: 10.1016/J.Bpj.2009.12.606 | 0.372 | |||
| 2009 | De Franceschi G, Frare E, Bubacco L, Mammi S, Fontana A, de Laureto PP. Molecular insights into the interaction between alpha-synuclein and docosahexaenoic acid. Journal of Molecular Biology. 394: 94-107. PMID 19747490 DOI: 10.1016/J.Jmb.2009.09.008 | 0.382 | |||
| 2009 | Bisaglia M, Tessari I, Mammi S, Bubacco L. Interaction between alpha-synuclein and metal ions, still looking for a role in the pathogenesis of Parkinson's disease. Neuromolecular Medicine. 11: 239-51. PMID 19669606 DOI: 10.1007/S12017-009-8082-1 | 0.32 | |||
| 2009 | Brucale M, Sandal M, Di Maio S, Rampioni A, Tessari I, Tosatto L, Bisaglia M, Bubacco L, Samorì B. Pathogenic mutations shift the equilibria of alpha-synuclein single molecules towards structured conformers. Chembiochem : a European Journal of Chemical Biology. 10: 176-83. PMID 19067456 DOI: 10.1002/Cbic.200800581 | 0.343 | |||
| 2009 | Bisaglia M, Mammi S, Bubacco L. Structural insights on physiological functions and pathological effects of alpha-synuclein. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 23: 329-40. PMID 18948383 DOI: 10.1096/Fj.08-119784 | 0.353 | |||
| 2009 | Arduini I, Soriano ME, Bisaglia M, Bernardi P, Bubacco L. P3.083 Dopamine oxidation products as mitochondrial endotoxins, a potential molecular mechanism for selective neurodegeneration in Parkinson disease Parkinsonism & Related Disorders. 15. DOI: 10.1016/S1353-8020(09)70647-9 | 0.322 | |||
| 2009 | Bisaglia M, Greggio E, Tosatto L, Munari F, Maric D, Tessari I, Polverino de Laureto P, Miller D, Mammi S, Cookson M, Bubacco L. P3.002 Modiflcation by dopamine adducts links a-synuclein to oxidative stress in Parkinson's disease Parkinsonism & Related Disorders. 15: S148. DOI: 10.1016/S1353-8020(09)70566-8 | 0.528 | |||
| 2008 | Tessari I, Bisaglia M, Valle F, Samorì B, Bergantino E, Mammi S, Bubacco L. The reaction of alpha-synuclein with tyrosinase: possible implications for Parkinson disease. The Journal of Biological Chemistry. 283: 16808-17. PMID 18390556 DOI: 10.1074/Jbc.M709014200 | 0.376 | |||
| 2008 | Campello S, Beltramini M, Giordano G, Di Muro P, Marino SM, Bubacco L. Role of the tertiary structure in the diphenol oxidase activity of Octopus vulgaris hemocyanin. Archives of Biochemistry and Biophysics. 471: 159-67. PMID 18237542 DOI: 10.1016/J.Abb.2008.01.006 | 0.317 | |||
| 2008 | Sandal M, Valle F, Tessari I, Mammi S, Bergantino E, Musiani F, Brucale M, Bubacco L, Samorì B. Conformational equilibria in monomeric alpha-synuclein at the single-molecule level. Plos Biology. 6: e6. PMID 18198943 DOI: 10.1371/Journal.Pbio.0060006 | 0.354 | |||
| 2007 | Bisaglia M, Mammi S, Bubacco L. Kinetic and structural analysis of the early oxidation products of dopamine: analysis of the interactions with alpha-synuclein. The Journal of Biological Chemistry. 282: 15597-605. PMID 17395592 DOI: 10.1074/Jbc.M610893200 | 0.373 | |||
| 2006 | Bisaglia M, Trolio A, Bellanda M, Bergantino E, Bubacco L, Mammi S. Structure and topology of the non-amyloid-beta component fragment of human alpha-synuclein bound to micelles: implications for the aggregation process. Protein Science : a Publication of the Protein Society. 15: 1408-16. PMID 16731975 DOI: 10.1110/Ps.052048706 | 0.344 | |||
| 2005 | Greggio E, Bergantino E, Carter D, Ahmad R, Costin GE, Hearing VJ, Clarimon J, Singleton A, Eerola J, Hellström O, Tienari PJ, Miller DW, Beilina A, Bubacco L, Cookson MR. Tyrosinase exacerbates dopamine toxicity but is not genetically associated with Parkinson's disease. Journal of Neurochemistry. 93: 246-56. PMID 15773923 DOI: 10.1111/J.1471-4159.2005.03019.X | 0.562 | |||
| 2005 | Tepper AW, Bubacco L, Canters GW. Interaction between the type-3 copper protein tyrosinase and the substrate analogue p-nitrophenol studied by NMR. Journal of the American Chemical Society. 127: 567-75. PMID 15643881 DOI: 10.1021/Ja0454687 | 0.316 | |||
| 2005 | Bisaglia M, Tessari I, Pinato L, Bellanda M, Giraudo S, Fasano M, Bergantino E, Bubacco L, Mammi S. A topological model of the interaction between alpha-synuclein and sodium dodecyl sulfate micelles. Biochemistry. 44: 329-39. PMID 15628875 DOI: 10.1021/Bi048448Q | 0.327 | |||
| 2005 | Bisaglia M, Trolio A, Tessari I, Bubacco L, Mammi S, Bergantino E. Cloning, expression, purification, and spectroscopic analysis of the fragment 57-102 of human alpha-synuclein. Protein Expression and Purification. 39: 90-6. PMID 15596364 DOI: 10.1016/J.Pep.2004.09.018 | 0.349 | |||
| 2004 | Bubacco L, van Gastel M, Benfatto M, Tepper AW, Canters GW. What are the structural features of the active site that define binuclear copper proteins function? Micron (Oxford, England : 1993). 35: 143-5. PMID 15036320 DOI: 10.1016/J.Micron.2003.10.046 | 0.324 | |||
| 2004 | Gatto S, De Filippis V, Spinozzi F, Di Muro P, Bubacco L, Beltramini M. Structural role of the copper ions in the dinuclear active site of Carcinus aestuarii hemocyanin. Micron (Oxford, England : 1993). 35: 43-4. PMID 15036286 DOI: 10.1016/J.Micron.2003.10.011 | 0.305 | |||
| 2003 | Bubacco L, Van Gastel M, Groenen EJ, Vijgenboom E, Canters GW. Spectroscopic characterization of the electronic changes in the active site of Streptomyces antibioticus tyrosinase upon binding of transition state analogue inhibitors. The Journal of Biological Chemistry. 278: 7381-9. PMID 12473668 DOI: 10.1074/Jbc.M206394200 | 0.319 | |||
| 2002 | Tepper AW, Bubacco L, Canters GW. Structural basis and mechanism of the inhibition of the type-3 copper protein tyrosinase from Streptomyces antibioticus by halide ions. The Journal of Biological Chemistry. 277: 30436-44. PMID 12048185 DOI: 10.1074/Jbc.M202461200 | 0.316 | |||
| 1998 | Zlateva T, Santagostini L, Bubacco L, Casella L, Salvato B, Beltramini M. Isolation of the met-derivative intermediate in the catalase-like activity of deoxygenated Octopus vulgaris hemocyanin Journal of Inorganic Biochemistry. 72: 211-215. DOI: 10.1016/S0162-0134(98)10082-X | 0.301 | |||
| 1997 | Alzuet G, Bubacco L, Casella L, Rocco GP, Salvato B, Beltramini M. The binding of azide to copper-containing and cobalt-containing forms of hemocyanin from the mediterranean crab Carcinus aestuarii. European Journal of Biochemistry. 247: 688-94. PMID 9266714 DOI: 10.1111/J.1432-1033.1997.00688.X | 0.317 | |||
| 1995 | Magliozzo RS, Bubacco L, McCracken J, Jiang F, Beltramini M, Salvato B, Peisach J. Cu(II) coordination in arthropod and mollusk green half-methemocyanins analyzed by electron spin-echo envelope modulation spectroscopy. Biochemistry. 34: 1513-23. PMID 7849010 DOI: 10.1021/Bi00005A007 | 0.306 | |||
| 1995 | Beltramini M, Bubacco L, Casella L, Alzuet G, Gullotti M, Salvato B. The oxidation of hemocyanin. Kinetics, reaction mechanism and characterization of met-hemocyanin product. European Journal of Biochemistry. 232: 98-105. PMID 7556177 DOI: 10.1111/J.1432-1033.1995.Tb20786.X | 0.313 | |||
| 1992 | Ricchelli F, Beltramini M, Bubacco L, Salvato B, Filippi B. Circular dichroism and fluorescence studies to probe the conformational properties of Rhus vernicifera laccase Inorganica Chimica Acta. 193: 237-243. DOI: 10.1016/S0020-1693(00)80358-8 | 0.313 | |||
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