Oliver Howes, MBBS - Publications

Affiliations: 
Clinical Sciences Centre Imperial College, London, London, England, United Kingdom 
Area:
Schizophrenia

265 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Guo X, McCutcheon RA, Pillinger T, Mizuno Y, Natesan S, Brown K, Howes O. The magnitude and heterogeneity of antidepressant response in depression: A meta-analysis of over 45,000 patients. Journal of Affective Disorders. 276: 991-1000. PMID 32750615 DOI: 10.1016/j.jad.2020.07.102  0.48
2020 Baumeister D, Ward T, Garety P, Jackson M, Morgan C, Charalambides M, Chadwick P, Howes O, Peters E. Need for care, adversity exposure and perceived stress in clinical and healthy voice-hearers. Psychological Medicine. 1-7. PMID 32686627 DOI: 10.1017/S0033291720002433  0.36
2020 McCutcheon RA, Jauhar S, Pepper F, Nour MM, Rogdaki M, Veronese M, Turkheimer FE, Egerton A, McGuire P, Mehta MM, Howes OD. The Topography of Striatal Dopamine and Symptoms in Psychosis: An Integrative Positron Emission Tomography and Magnetic Resonance Imaging Study. Biological Psychiatry. Cognitive Neuroscience and Neuroimaging. PMID 32653578 DOI: 10.1016/j.bpsc.2020.04.004  1
2020 Cheng PWC, Chang WC, Lo GG, Chan KWS, Lee HME, Hui LMC, Suen YN, Leung YLE, Au Yeung KMP, Chen S, Mak KFH, Sham PC, Santangelo B, Veronese M, Ho CL, ... ... Howes OD, et al. The role of dopamine dysregulation and evidence for the transdiagnostic nature of elevated dopamine synthesis in psychosis: a positron emission tomography (PET) study comparing schizophrenia, delusional disorder, and other psychotic disorders. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 32612207 DOI: 10.1038/s41386-020-0740-x  0.4
2020 Siskind D, Honer WG, Clark S, Correll CU, Hasan A, Howes O, Kane JM, Kelly DL, Laitman R, Lee J, MacCabe JH, Myles N, Nielsen J, Schulte PF, Taylor D, et al. Clozapine and COVID-19: The authors respond. Journal of Psychiatry & Neuroscience : Jpn. 45: E1-E2. PMID 32584530 DOI: 10.1503/jpn.2045302  0.32
2020 Beck K, Hindley G, Borgan F, Ginestet C, McCutcheon R, Brugger S, Driesen N, Ranganathan M, D'Souza DC, Taylor M, Krystal JH, Howes OD. Association of Ketamine With Psychiatric Symptoms and Implications for Its Therapeutic Use and for Understanding Schizophrenia: A Systematic Review and Meta-analysis. Jama Network Open. 3: e204693. PMID 32437573 DOI: 10.1001/jamanetworkopen.2020.4693  0.48
2020 Howes OD, Hird EJ, Adams RA, Corlett PR, McGuire P. Aberrant Salience, Information Processing, and Dopaminergic Signaling in People at Clinical High Risk for Psychosis. Biological Psychiatry. PMID 32430200 DOI: 10.1016/j.biopsych.2020.03.012  0.72
2020 Kokkinou M, Irvine EE, Bonsall DR, Natesan S, Wells LA, Smith M, Glegola J, Paul EJ, Tossell K, Veronese M, Khadayate S, Dedic N, Hopkins SC, Ungless MA, Withers DJ, ... Howes OD, et al. Reproducing the dopamine pathophysiology of schizophrenia and approaches to ameliorate it: a translational imaging study with ketamine. Molecular Psychiatry. PMID 32382134 DOI: 10.1038/s41380-020-0740-6  0.4
2020 Siskind D, Honer WG, Clark S, Correll CU, Hasan A, Howes O, Kane JM, Kelly DL, Laitman R, Lee J, MacCabe JH, Myles N, Nielsen J, Schulte PF, Taylor D, et al. Consensus statement on the use of clozapine during the COVID-19 pandemic. Journal of Psychiatry & Neuroscience : Jpn. 45: 200061. PMID 32297722 DOI: 10.1503/jpn.200061  0.32
2020 Marques TR, Ashok AH, Angelescu I, Borgan F, Myers J, Lingford-Hughes A, Nutt DJ, Veronese M, Turkheimer FE, Howes OD. GABA-A receptor differences in schizophrenia: a positron emission tomography study using [C]Ro154513. Molecular Psychiatry. PMID 32296127 DOI: 10.1038/s41380-020-0711-y  0.52
2020 Siskind D, Honer WG, Clark S, Correll CU, Hasan A, Howes O, Kane JM, Kelly DL, Laitman R, Lee J, MacCabe JH, Myles N, Nielsen J, Schulte PF, Taylor D, et al. Consensus statement on the use of clozapine during the COVID-19 pandemic Journal of Psychiatry & Neuroscience : Jpn. 45: 2. PMID 32242646  0.32
2020 Adams RA, Bush D, Zheng F, Meyer SS, Kaplan R, Orfanos S, Marques TR, Howes OD, Burgess N. Impaired theta phase coupling underlies frontotemporal dysconnectivity in schizophrenia. Brain : a Journal of Neurology. PMID 32236540 DOI: 10.1093/brain/awaa035  0.52
2020 Hindley G, Beck K, Borgan F, Ginestet CE, McCutcheon R, Kleinloog D, Ganesh S, Radhakrishnan R, D'Souza DC, Howes OD. Psychiatric symptoms caused by cannabis constituents: a systematic review and meta-analysis. The Lancet. Psychiatry. PMID 32197092 DOI: 10.1016/S2215-0366(20)30074-2  0.48
2020 Osimo EF, Pillinger T, Rodriguez IM, Khandaker GM, Pariante CM, Howes OD. Inflammatory Markers in Depression: a Meta-Analysis of Mean Differences and Variability in 5,166 Patients and 5,083 Controls. Brain, Behavior, and Immunity. PMID 32113908 DOI: 10.1016/j.bbi.2020.02.010  0.48
2020 Adams RA, Moutoussis M, Nour MM, Dahoun T, Lewis D, Illingworth B, Veronese M, Mathys C, de Boer L, Guitart-Masip M, Friston KJ, Howes OD, Roiser JP. Variability in Action Selection Relates to Striatal Dopamine 2/3 Receptor Availability in Humans: A PET Neuroimaging Study Using Reinforcement Learning and Active Inference Models. Cerebral Cortex (New York, N.Y. : 1991). PMID 32083297 DOI: 10.1093/cercor/bhz327  1
2020 Onwordi EC, Halff EF, Whitehurst T, Mansur A, Cotel MC, Wells L, Creeney H, Bonsall D, Rogdaki M, Shatalina E, Reis Marques T, Rabiner EA, Gunn RN, Natesan S, Vernon AC, ... Howes OD, et al. Synaptic density marker SV2A is reduced in schizophrenia patients and unaffected by antipsychotics in rats. Nature Communications. 11: 246. PMID 31937764 DOI: 10.1038/s41467-019-14122-0  0.48
2020 Rogdaki M, Gudbrandsen M, McCutcheon RA, Blackmore CE, Brugger S, Ecker C, Craig MC, Daly E, Murphy DGM, Howes O. Magnitude and heterogeneity of brain structural abnormalities in 22q11.2 deletion syndrome: a meta-analysis. Molecular Psychiatry. PMID 31925327 DOI: 10.1038/s41380-019-0638-3  0.52
2020 McCutcheon RA, Krystal JH, Howes OD. Dopamine and glutamate in schizophrenia: biology, symptoms and treatment. World Psychiatry : Official Journal of the World Psychiatric Association (Wpa). 19: 15-33. PMID 31922684 DOI: 10.1002/wps.20693  0.48
2020 Osimo EF, Brugger SP, de Marvao A, Pillinger T, Whitehurst T, Statton B, Quinlan M, Berry A, Cook SA, O'Regan DP, Howes OD. Cardiac structure and function in schizophrenia: cardiac magnetic resonance imaging study. The British Journal of Psychiatry : the Journal of Mental Science. 1-8. PMID 31915079 DOI: 10.1192/bjp.2019.268  0.48
2020 Pillinger T, McCutcheon RA, Vano L, Mizuno Y, Arumuham A, Hindley G, Beck K, Natesan S, Efthimiou O, Cipriani A, Howes OD. Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis. The Lancet. Psychiatry. 7: 64-77. PMID 31860457 DOI: 10.1016/S2215-0366(19)30416-X  0.48
2019 Modinos G, Allen P, Zugman A, Dima D, Azis M, Samson C, Bonoldi I, Quinn B, Gifford GWG, Smart SE, Antoniades M, Bossong MG, Broome MR, Perez J, Howes OD, et al. Neural Circuitry of Novelty Salience Processing in Psychosis Risk: Association With Clinical Outcome. Schizophrenia Bulletin. PMID 32227226 DOI: 10.1093/schbul/sbz089  0.88
2019 Barnes TR, Drake R, Paton C, Cooper SJ, Deakin B, Ferrier IN, Gregory CJ, Haddad PM, Howes OD, Jones I, Joyce EM, Lewis S, Lingford-Hughes A, MacCabe JH, Owens DC, et al. Evidence-based guidelines for the pharmacological treatment of schizophrenia: Updated recommendations from the British Association for Psychopharmacology. Journal of Psychopharmacology (Oxford, England). 269881119889296. PMID 31829775 DOI: 10.1177/0269881119889296  0.6
2019 Borgan F, O'Daly O, Veronese M, Reis Marques T, Laurikainen H, Hietala J, Howes O. The neural and molecular basis of working memory function in psychosis: a multimodal PET-fMRI study. Molecular Psychiatry. PMID 31801965 DOI: 10.1038/s41380-019-0619-6  0.4
2019 Mizuno Y, McCutcheon RA, Brugger SP, Howes OD. Heterogeneity and efficacy of antipsychotic treatment for schizophrenia with or without treatment resistance: a meta-analysis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31766049 DOI: 10.1038/s41386-019-0577-3  0.48
2019 Dahoun T, Nour MM, McCutcheon RA, Adams RA, Bloomfield MAP, Howes OD. The relationship between childhood trauma, dopamine release and dexamphetamine-induced positive psychotic symptoms: a [C]-(+)-PHNO PET study. Translational Psychiatry. 9: 287. PMID 31712556 DOI: 10.1038/s41398-019-0627-y  1
2019 Bloomfield MA, McCutcheon RA, Kempton M, Freeman TP, Howes O. The effects of psychosocial stress on dopaminergic function and the acute stress response. Elife. 8. PMID 31711569 DOI: 10.7554/eLife.46797  0.48
2019 D'Ambrosio E, Jauhar S, Kim S, Veronese M, Rogdaki M, Pepper F, Bonoldi I, Kotoula V, Kempton MJ, Turkheimer F, Kwon JS, Kim E, Howes OD. The relationship between grey matter volume and striatal dopamine function in psychosis: a multimodal F-DOPA PET and voxel-based morphometry study. Molecular Psychiatry. PMID 31690805 DOI: 10.1038/s41380-019-0570-6  0.88
2019 McCutcheon RA, Reis Marques T, Howes OD. Schizophrenia-An Overview. Jama Psychiatry. 1-10. PMID 31664453 DOI: 10.1001/jamapsychiatry.2019.3360  0.48
2019 McCutcheon RA, Reis Marques T, Howes OD. Treatment of First-Episode Schizophrenia in a Young Woman. Jama Psychiatry. PMID 31664438 DOI: 10.1001/jamapsychiatry.2019.3369  0.48
2019 Rogdaki M, Hathway P, Gudbrandsen M, McCutcheon RA, Jauhar S, Daly E, Howes O. Glutamatergic function in a genetic high-risk group for psychosis: A proton magnetic resonance spectroscopy study in individuals with 22q11.2 deletion. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 31648854 DOI: 10.1016/j.euroneuro.2019.09.005  0.52
2019 Howes OD, Bonoldi I, McCutcheon RA, Azis M, Antoniades M, Bossong M, Modinos G, Perez J, Stone JM, Santangelo B, Veronese M, Grace A, Allen P, McGuire PK. Glutamatergic and dopaminergic function and the relationship to outcome in people at clinical high risk of psychosis: a multi-modal PET-magnetic resonance brain imaging study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 31618752 DOI: 10.1038/s41386-019-0541-2  0.88
2019 Barešić A, Nash AJ, Dahoun T, Howes O, Lenhard B. Understanding the genetics of neuropsychiatric disorders: the potential role of genomic regulatory blocks. Molecular Psychiatry. PMID 31616042 DOI: 10.1038/s41380-019-0518-x  0.52
2019 McCutcheon RA, Pillinger T, Mizuno Y, Montgomery A, Pandian H, Vano L, Marques TR, Howes OD. The efficacy and heterogeneity of antipsychotic response in schizophrenia: A meta-analysis. Molecular Psychiatry. PMID 31471576 DOI: 10.1038/s41380-019-0502-5  0.48
2019 D'Ambrosio E, Dahoun T, Pardiñas AF, Veronese M, Bloomfield MAP, Jauhar S, Bonoldi I, Rogdaki M, Froudist-Walsh S, Walters JTR, Howes OD. The effect of a genetic variant at the schizophrenia associated AS3MT/BORCS7 locus on striatal dopamine function: A PET imaging study. Psychiatry Research. Neuroimaging. 291: 34-41. PMID 31386983 DOI: 10.1016/j.pscychresns.2019.07.005  0.88
2019 Merritt K, Perez-Iglesias R, Sendt KV, Goozee R, Jauhar S, Pepper F, Barker GJ, Glenthøj B, Arango C, Lewis S, Kahn R, Stone J, Howes O, Dazzan P, McGuire P, et al. Remission from antipsychotic treatment in first episode psychosis related to longitudinal changes in brain glutamate. Npj Schizophrenia. 5: 12. PMID 31371817 DOI: 10.1038/s41537-019-0080-1  0.8
2019 Gaughran F, Stahl D, Stringer D, Hopkins D, Atakan Z, Greenwood K, Patel A, Smith S, Gardner-Sood P, Lally J, Heslin M, Stubbs B, Bonaccorso S, Kolliakou A, Howes O, et al. Effect of lifestyle, medication and ethnicity on cardiometabolic risk in the year following the first episode of psychosis: prospective cohort study. The British Journal of Psychiatry : the Journal of Mental Science. 1-8. PMID 31347480 DOI: 10.1192/bjp.2019.159  0.92
2019 Kaar SJ, Natesan S, McCutcheon R, Howes OD. Antipsychotics: mechanisms underlying clinical response and side-effects and novel treatment approaches based on pathophysiology. Neuropharmacology. 107704. PMID 31299229 DOI: 10.1016/j.neuropharm.2019.107704  0.48
2019 Nour MM, Dahoun T, McCutcheon RA, Adams RA, Wall MB, Howes OD. Task-induced functional brain connectivity mediates the relationship between striatal D2/3 receptors and working memory. Elife. 8. PMID 31290741 DOI: 10.7554/eLife.45045  1
2019 Borgan F, Laurikainen H, Veronese M, Marques TR, Haaparanta-Solin M, Solin O, Dahoun T, Rogdaki M, Salokangas RK, Karukivi M, Di Forti M, Turkheimer F, Hietala J, Howes O. In Vivo Availability of Cannabinoid 1 Receptor Levels in Patients With First-Episode Psychosis. Jama Psychiatry. PMID 31268519 DOI: 10.1001/jamapsychiatry.2019.1427  0.56
2019 Borgan FR, Jauhar S, McCutcheon RA, Pepper FS, Rogdaki M, Lythgoe DJ, Howes OD. Glutamate levels in the anterior cingulate cortex in un-medicated first episode psychosis: a proton magnetic resonance spectroscopy study. Scientific Reports. 9: 8685. PMID 31266965 DOI: 10.1038/s41598-019-45018-0  0.52
2019 Dahoun T, Nour MM, Adams RA, Trossbach S, Lee SH, Patel H, Curtis C, Korth C, Howes OD. Disrupted-in-Schizophrenia 1 (DISC1) functional polymorphisms and D /D receptor availability: a [ C]-(+)-PHNO imaging study. Genes, Brain, and Behavior. e12596. PMID 31264367 DOI: 10.1111/gbb.12596  1
2019 Beck K, McCutcheon R, Stephenson L, Schilderman M, Patel N, Ramsay R, Howes OD. Prevalence of treatment-resistant psychoses in the community: A naturalistic study. Journal of Psychopharmacology (Oxford, England). 269881119855995. PMID 31241396 DOI: 10.1177/0269881119855995  0.48
2019 Beck K, Lally J, Shergill SS, Bloomfield MAP, MacCabe JH, Gaughran F, Howes OD. Prevalence of serum N-methyl-d-aspartate receptor autoantibodies in refractory psychosis - ADDENDUM. The British Journal of Psychiatry : the Journal of Mental Science. 1. PMID 31180301 DOI: 10.1192/bjp.2019.141  0.44
2019 Pillinger T, Osimo EF, de Marvao A, Berry MA, Whitehurst T, Statton B, Quinlan M, Brugger S, Vazir A, Cook SA, O'Regan DP, Howes OD. Cardiac structure and function in patients with schizophrenia taking antipsychotic drugs: an MRI study. Translational Psychiatry. 9: 163. PMID 31175270 DOI: 10.1038/s41398-019-0502-x  0.48
2019 Borgan F, Beck K, Butler E, McCutcheon R, Veronese M, Vernon A, Howes OD. The effects of cannabinoid 1 receptor compounds on memory: a meta-analysis and systematic review across species. Psychopharmacology. PMID 31165913 DOI: 10.1007/s00213-019-05283-3  0.48
2019 Bonoldi I, Allen P, Madeira L, Tognin S, Bossong MG, Azis M, Samson C, Quinn B, Calem M, Valmaggia L, Modinos G, Stone J, Perez J, Howes O, Politi P, et al. Basic Self-Disturbances Related to Reduced Anterior Cingulate Volume in Subjects at Ultra-High Risk for Psychosis. Frontiers in Psychiatry. 10: 254. PMID 31133887 DOI: 10.3389/fpsyt.2019.00254  0.88
2019 Dahoun T, Calcia MA, Veronese M, Bloomfield P, Reis Marques T, Turkheimer F, Howes OD. The association of psychosocial risk factors for mental health with a brain marker altered by inflammation: A translocator protein (TSPO) PET imaging study. Brain, Behavior, and Immunity. PMID 31112791 DOI: 10.1016/j.bbi.2019.05.023  0.56
2019 Jauhar S, Howes OD. Understanding and Predicting Variability in Response to Treatment in Psychotic Disorders: In Vivo Findings. Clinical Pharmacology and Therapeutics. PMID 30883694 DOI: 10.1002/cpt.1357  0.4
2019 Pillinger T, Rogdaki M, McCutcheon RA, Hathway P, Egerton A, Howes OD. Altered glutamatergic response and functional connectivity in treatment resistant schizophrenia: the effect of riluzole and therapeutic implications. Psychopharmacology. PMID 30820633 DOI: 10.1007/s00213-019-5188-5  0.8
2019 Veronese M, Moro L, Arcolin M, Dipasquale O, Rizzo G, Expert P, Khan W, Fisher PM, Svarer C, Bertoldo A, Howes O, Turkheimer FE. Covariance statistics and network analysis of brain PET imaging studies. Scientific Reports. 9: 2496. PMID 30792460 DOI: 10.1038/s41598-019-39005-8  0.52
2019 Borgan F, O'Daly O, Hoang K, Veronese M, Withers D, Batterham R, Howes O. Neural Responsivity to Food Cues in Patients With Unmedicated First-Episode Psychosis. Jama Network Open. 2: e186893. PMID 30646204 DOI: 10.1001/jamanetworkopen.2018.6893  0.4
2019 McCutcheon RA, Abi-Dargham A, Howes OD. Schizophrenia, Dopamine and the Striatum: From Biology to Symptoms. Trends in Neurosciences. PMID 30621912 DOI: 10.1016/j.tins.2018.12.004  0.48
2018 McCutcheon RA, Bloomfield MAP, Dahoun T, Mehta M, Howes OD. Chronic psychosocial stressors are associated with alterations in salience processing and corticostriatal connectivity. Schizophrenia Research. PMID 30573409 DOI: 10.1016/j.schres.2018.12.011  0.52
2018 Kim S, Jung WH, Howes OD, Veronese M, Turkheimer FE, Lee YS, Lee JS, Kim E, Kwon JS. Frontostriatal functional connectivity and striatal dopamine synthesis capacity in schizophrenia in terms of antipsychotic responsiveness: an [18F]DOPA PET and fMRI study. Psychological Medicine. 1-10. PMID 30460891 DOI: 10.1017/S0033291718003471  0.52
2018 Bossong MG, Antoniades M, Azis M, Samson C, Quinn B, Bonoldi I, Modinos G, Perez J, Howes OD, Stone JM, Allen P, McGuire P. Association of Hippocampal Glutamate Levels With Adverse Outcomes in Individuals at Clinical High Risk for Psychosis. Jama Psychiatry. PMID 30427993 DOI: 10.1001/jamapsychiatry.2018.3252  0.88
2018 Pillinger T, Osimo EF, Brugger S, Mondelli V, McCutcheon RA, Howes OD. A Meta-analysis of Immune Parameters, Variability, and Assessment of Modal Distribution in Psychosis and Test of the Immune Subgroup Hypothesis. Schizophrenia Bulletin. PMID 30407606 DOI: 10.1093/schbul/sby160  0.48
2018 McCutcheon RA, Nour MM, Dahoun T, Jauhar S, Pepper F, Expert P, Veronese M, Adams RA, Turkheimer F, Mehta MA, Howes OD. Mesolimbic Dopamine Function Is Related to Salience Network Connectivity: An Integrative Positron Emission Tomography and Magnetic Resonance Study. Biological Psychiatry. PMID 30389131 DOI: 10.1016/j.biopsych.2018.09.010  1
2018 Marques TR, Ashok AH, Pillinger T, Veronese M, Turkheimer FE, Dazzan P, Sommer IEC, Howes OD. Neuroinflammation in schizophrenia: meta-analysis of in vivo microglial imaging studies. Psychological Medicine. 1-11. PMID 30355368 DOI: 10.1017/S0033291718003057  0.52
2018 McGinnity CJ, Årstad E, Beck K, Brooks DJ, Coles JP, Duncan JS, Galovic M, Hinz R, Hirani E, Howes OD, Jones PA, Koepp MJ, Luo F, Riaño Barros DA, Singh N, et al. Comment on " In Vivo [F]GE-179 Brain Signal Does Not Show NMDA-Specific Modulation with Drug Challenges in Rodents and Nonhuman Primates". Acs Chemical Neuroscience. PMID 30346706 DOI: 10.1021/acschemneuro.8b00246  0.36
2018 Pillinger T, D'Ambrosio E, McCutcheon R, Howes OD. Correction to: Is psychosis a multisystem disorder? A meta-review of central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models. Molecular Psychiatry. PMID 30337658 DOI: 10.1038/s41380-018-0275-2  0.48
2018 Tonietto M, Rizzo G, Veronese M, Borgan F, Bloomfield P, Howes O, Bertoldo A. A unified framework for plasma data modelling in dynamic Positron Emission Tomography studies. Ieee Transactions On Bio-Medical Engineering. PMID 30307849 DOI: 10.1109/TBME.2018.2874308  0.4
2018 Nour MM, Dahoun T, Schwartenbeck P, Adams RA, FitzGerald THB, Coello C, Wall MB, Dolan RJ, Howes OD. Dopaminergic basis for signaling belief updates, but not surprise, and the link to paranoia. Proceedings of the National Academy of Sciences of the United States of America. PMID 30297411 DOI: 10.1073/pnas.1809298115  1
2018 Laurikainen H, Tuominen L, Tikka M, Merisaari H, Armio RL, Sormunen E, Borgan F, Veronese M, Howes O, Haaparanta-Solin M, Solin O, Hietala J. Sex difference in brain CB1 receptor availability in man. Neuroimage. 184: 834-842. PMID 30296558 DOI: 10.1016/j.neuroimage.2018.10.013  0.4
2018 Horder J, Andersson M, Mendez MA, Singh N, Tangen Ä, Lundberg J, Gee A, Halldin C, Veronese M, Bölte S, Farde L, Sementa T, Cash D, Higgins K, Spain D, ... ... Howes OD, et al. GABA receptor availability is not altered in adults with autism spectrum disorder or in mouse models. Science Translational Medicine. 10. PMID 30282698 DOI: 10.1126/scitranslmed.aam8434  0.56
2018 Modinos G, Şimşek F, Azis M, Bossong M, Bonoldi I, Samson C, Quinn B, Perez J, Broome MR, Zelaya F, Lythgoe DJ, Howes OD, Stone JM, Grace AA, Allen P, et al. Correction: Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 30279560 DOI: 10.1038/s41386-018-0118-5  0.88
2018 Jauhar S, McCutcheon R, Borgan F, Veronese M, Nour M, Pepper F, Rogdaki M, Stone J, Egerton A, Turkheimer F, McGuire P, Howes OD. The relationship between cortical glutamate and striatal dopamine in first-episode psychosis: a cross-sectional multimodal PET and magnetic resonance spectroscopy imaging study. The Lancet. Psychiatry. PMID 30236864 DOI: 10.1016/S2215-0366(18)30268-2  0.8
2018 Lally J, Ajnakina O, Singh N, Gardner-Sood P, Stubbs B, Stringer D, Di Forti M, David AS, Smith S, Murray RM, Howes OD, Gaughran F. Vitamin D and clinical symptoms in First Episode Psychosis (FEP): A prospective cohort study. Schizophrenia Research. PMID 30154029 DOI: 10.1016/j.schres.2018.08.011  0.92
2018 Jauhar S, Veronese M, Nour MM, Rogdaki M, Hathway P, Natesan S, Turkheimer F, Stone J, Egerton A, McGuire P, Kapur S, Howes OD. The Effects of Antipsychotic Treatment on Presynaptic Dopamine Synthesis Capacity in First-Episode Psychosis: A Positron Emission Tomography Study. Biological Psychiatry. PMID 30122287 DOI: 10.1016/j.biopsych.2018.07.003  1
2018 Dahoun T, Pardiñas AF, Veronese M, Bloomfield MAP, Jauhar S, Bonoldi I, Froudist-Walsh S, Nosarti C, Korth C, Hennah W, Walters J, Prata D, Howes OD. The effect of the DISC1 Ser704Cys polymorphism on striatal dopamine synthesis capacity: an [18F]-DOPA PET study. Human Molecular Genetics. PMID 29945223 DOI: 10.1093/hmg/ddy242  0.88
2018 Pillinger T, D'Ambrosio E, McCutcheon R, Howes OD. Is psychosis a multisystem disorder? A meta-review of central nervous system, immune, cardiometabolic, and endocrine alterations in first-episode psychosis and perspective on potential models. Molecular Psychiatry. PMID 29743584 DOI: 10.1038/s41380-018-0058-9  0.48
2018 Shin S, Kim S, Seo S, Lee JS, Howes OD, Kim E, Kwon JS. The relationship between dopamine receptor blockade and cognitive performance in schizophrenia: a [C]-raclopride PET study with aripiprazole. Translational Psychiatry. 8: 87. PMID 29686254 DOI: 10.1038/s41398-018-0134-6  0.36
2018 Jauhar S, Veronese M, Nour MM, Rogdaki M, Hathway P, Turkheimer FE, Stone J, Egerton A, McGuire P, Kapur S, Howes OD. Determinants of treatment response in first-episode psychosis: an F-DOPA PET study. Molecular Psychiatry. PMID 29679071 DOI: 10.1038/s41380-018-0042-4  1
2018 Nour MM, McCutcheon R, Howes OD. The Relationship Between Dopamine Synthesis Capacity and Release: Implications for Psychosis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 43: 1195-1196. PMID 29670249 DOI: 10.1038/npp.2017.293  1
2018 Plavén-Sigray P, Matheson GJ, Collste K, Ashok AH, Coughlin JM, Howes OD, Mizrahi R, Pomper MG, Rusjan P, Veronese M, Wang Y, Cervenka S. Positron Emission Tomography Studies of the Glial Cell Marker Translocator Protein in Patients With Psychosis: A Meta-analysis Using Individual Participant Data. Biological Psychiatry. PMID 29653835 DOI: 10.1016/j.biopsych.2018.02.1171  0.4
2018 Modinos G, Şimşek F, Azis M, Bossong M, Bonoldi I, Samson C, Quinn B, Perez J, Broome MR, Zelaya F, Lythgoe DJ, Howes OD, Stone JM, Grace AA, Allen P, et al. Prefrontal GABA levels, hippocampal resting perfusion and the risk of psychosis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 29440719 DOI: 10.1038/s41386-017-0004-6  0.88
2018 McCutcheon R, Bloomfield MAP, Dahoun T, Quinlan M, Terbeck S, Mehta M, Howes O. Amygdala reactivity in ethnic minorities and its relationship to the social environment: an fMRI study. Psychological Medicine. 1-8. PMID 29328019 DOI: 10.1017/S0033291717003506  0.52
2017 McCutcheon R, Beck K, Jauhar S, Howes OD. Defining the Locus of Dopaminergic Dysfunction in Schizophrenia: A Meta-analysis and Test of the Mesolimbic Hypothesis. Schizophrenia Bulletin. PMID 29301039 DOI: 10.1093/schbul/sbx180  0.48
2017 Allen P, Azis M, Modinos G, Bossong MG, Bonoldi I, Samson C, Quinn B, Kempton MJ, Howes OD, Stone JM, Calem M, Perez J, Bhattacharayya S, Broome MR, Grace AA, et al. Increased Resting Hippocampal and Basal Ganglia Perfusion in People at Ultra High Risk for Psychosis: Replication in a Second Cohort. Schizophrenia Bulletin. PMID 29294102 DOI: 10.1093/schbul/sbx169  0.88
2017 Howes OD, Rogdaki M, Findon JL, Wichers RH, Charman T, King BH, Loth E, McAlonan GM, McCracken JT, Parr JR, Povey C, Santosh P, Wallace S, Simonoff E, Murphy DG. Autism spectrum disorder: Consensus guidelines on assessment, treatment and research from the British Association for Psychopharmacology. Journal of Psychopharmacology (Oxford, England). 269881117741766. PMID 29237331 DOI: 10.1177/0269881117741766  0.48
2017 Lee J, Kim BH, Kim E, Howes OD, Cho KIK, Yoon YB, Kwon JS. Higher serotonin transporter availability in early-onset obsessive-compulsive disorder patients undergoing escitalopram treatment: A [11 C]DASB PET study. Human Psychopharmacology. PMID 29210107 DOI: 10.1002/hup.2642  0.36
2017 Froudist-Walsh S, Bloomfield MA, Veronese M, Kroll J, Karolis VR, Jauhar S, Bonoldi I, McGuire PK, Kapur S, Murray RM, Nosarti C, Howes O. The effect of perinatal brain injury on dopaminergic function and hippocampal volume in adult life. Elife. 6. PMID 29179814 DOI: 10.7554/eLife.29088  0.92
2017 Rizzo G, Veronese M, Tonietto M, Bodini B, Stankoff B, Wimberley C, Lavisse S, Bottlaender M, Bloomfield PS, Howes O, Zanotti-Fregonara P, Turkheimer FE, Bertoldo A. Generalization of endothelial modelling of TSPO PET imaging: Considerations on tracer affinities. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17742004. PMID 29135382 DOI: 10.1177/0271678X17742004  0.52
2017 Bhattacharyya S, Egerton A, Kim E, Rosso L, Riano Barros D, Hammers A, Brammer M, Turkheimer FE, Howes OD, McGuire P. Acute induction of anxiety in humans by delta-9-tetrahydrocannabinol related to amygdalar cannabinoid-1 (CB1) receptors. Scientific Reports. 7: 15025. PMID 29101333 DOI: 10.1038/s41598-017-14203-4  0.8
2017 Jauhar S, Nour MM, Veronese M, Rogdaki M, Bonoldi I, Azis M, Turkheimer F, McGuire P, Young AH, Howes OD. A Test of the Transdiagnostic Dopamine Hypothesis of Psychosis Using Positron Emission Tomographic Imaging in Bipolar Affective Disorder and Schizophrenia. Jama Psychiatry. PMID 29049482 DOI: 10.1001/jamapsychiatry.2017.2943  1
2017 Modinos G, Simsek F, Horder J, Bossong M, Bonoldi I, Azis M, Perez J, Broome M, Lythgoe DJ, Stone JM, Howes OD, Murphy DG, Grace AA, Allen P, McGuire P. Cortical GABA In Subjects At Ultra-High Risk Of Psychosis: Relationship To Negative Prodromal Symptoms. The International Journal of Neuropsychopharmacology. PMID 29020419 DOI: 10.1093/ijnp/pyx076  0.88
2017 Pillinger T, Beck K, Stubbs B, Howes OD. Cholesterol and triglyceride levels in first-episode psychosis: systematic review and meta-analysis. The British Journal of Psychiatry : the Journal of Mental Science. PMID 28982658 DOI: 10.1192/bjp.bp.117.200907  0.48
2017 Murray RM, Bhavsar V, Tripoli G, Howes O. 30 Years on: How the Neurodevelopmental Hypothesis of Schizophrenia Morphed into the Developmental Risk Factor Model of Psychosis. Schizophrenia Bulletin. PMID 28981842 DOI: 10.1093/schbul/sbx121  0.92
2017 Bonsall DR, Kokkinou M, Veronese M, Coello C, Wells LA, Howes OD. Single cocaine exposure does not alter striatal presynaptic dopamine function in mice: an [(18) F]-FDOPA PET study. Journal of Neurochemistry. PMID 28921596 DOI: 10.1111/jnc.14223  0.52
2017 Selvaraj S, Bloomfield PS, Cao B, Veronese M, Turkheimer F, Howes OD. Brain TSPO imaging and gray matter volume in schizophrenia patients and in people at ultra high risk of psychosis: An [(11)C]PBR28 study. Schizophrenia Research. PMID 28893493 DOI: 10.1016/j.schres.2017.08.063  0.56
2017 Selvaraj S, Walker C, Arnone D, Cao B, Faulkner P, Cowen PJ, Roiser JP, Howes O. Effect of Citalopram on Emotion Processing in Humans: A Combined 5-HT1A [(11)C]CUMI-101 PET and Functional MRI Study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 28776580 DOI: 10.1038/npp.2017.166  0.6
2017 Lally J, Ajnakina O, Stubbs B, Williams HR, Colizzi M, Carra E, Fraietta S, Gardner-Sood P, Greenwood KE, Atakan Z, Mondelli V, Ismail K, Howes O, Taylor DM, Smith S, et al. Hyperprolactinaemia in first episode psychosis - A longitudinal assessment. Schizophrenia Research. PMID 28755878 DOI: 10.1016/j.schres.2017.07.037  0.92
2017 Lapa CO, Rocha GP, Marques TR, Howes O, Smith S, Monteiro RT, Zorzetti R, Spanemberg L. Translation and cross-cultural adaptation of the Sexual Function Questionnaire (SFQ) into Brazilian Portuguese. Trends in Psychiatry and Psychotherapy. 39: 110-115. PMID 28700040 DOI: 10.1590/2237-6089-2016-0089  0.44
2017 Veronese M, Reis Marques T, Bloomfield PS, Rizzo G, Singh N, Jones D, Agushi E, Mosses D, Bertoldo A, Howes O, Roncaroli F, Turkheimer FE. Kinetic modelling of [(11)C]PBR28 for 18 kDa translocator protein PET data: A validation study of vascular modelling in the brain using XBD173 and tissue analysis. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17712388. PMID 28580888 DOI: 10.1177/0271678X17712388  0.52
2017 Pillinger T, Beck K, Howes O. First-Episode Schizophrenia and Diabetes Risk-Reply. Jama Psychiatry. PMID 28538995 DOI: 10.1001/jamapsychiatry.2017.0765  0.48
2017 Pillinger T, Beck K, Gobjila C, Donocik JG, Jauhar S, Howes OD. Impaired Glucose Homeostasis in First-Episode Schizophrenia: A Systematic Review and Meta-analysis. Jama Psychiatry. PMID 28097367 DOI: 10.1001/jamapsychiatry.2016.3803  0.48
2017 Egerton A, Howes OD, Houle S, McKenzie K, Valmaggia LR, Bagby MR, Tseng HH, Bloomfield MA, Kenk M, Bhattacharyya S, Suridjan I, Chaddock CA, Winton-Brown TT, Allen P, Rusjan P, et al. Elevated Striatal Dopamine Function in Immigrants and Their Children: A Risk Mechanism for Psychosis. Schizophrenia Bulletin. PMID 28057720 DOI: 10.1093/schbul/sbw181  0.8
2016 Howes OD, McCutcheon R, Agid O, de Bartolomeis A, van Beveren NJ, Birnbaum ML, Bloomfield MA, Bressan RA, Buchanan RW, Carpenter WT, Castle DJ, Citrome L, Daskalakis ZJ, Davidson M, Drake RJ, et al. Treatment-Resistant Schizophrenia: Treatment Response and Resistance in Psychosis (TRRIP) Working Group Consensus Guidelines on Diagnosis and Terminology. The American Journal of Psychiatry. appiajp201616050503. PMID 27919182 DOI: 10.1176/appi.ajp.2016.16050503  0.48
2016 Kim E, Howes OD, Veronese M, Beck K, Seo S, Park JW, Lee JS, Lee YS, Kwon JS. Presynaptic Dopamine Capacity in Patients with Treatment Resistant Schizophrenia Taking Clozapine: An [(18)F]DOPA PET Study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. PMID 27857125 DOI: 10.1038/npp.2016.258  0.4
2016 Murray RM, Quattrone D, Natesan S, van Os J, Nordentoft M, Howes O, Di Forti M, Taylor D. Should psychiatrists be more cautious about the long-term prophylactic use of antipsychotics? The British Journal of Psychiatry : the Journal of Mental Science. 209: 361-365. PMID 27802977 DOI: 10.1192/bjp.bp.116.182683  0.92
2016 Howes OD, McCutcheon R, Owen MJ, Murray RM. The Role of Genes, Stress, and Dopamine in the Development of Schizophrenia. Biological Psychiatry. PMID 27720198 DOI: 10.1016/j.biopsych.2016.07.014  0.92
2016 Kim E, Howes OD, Kim BH, Chon MW, Seo S, Turkheimer FE, Lee JS, Lee YS, Kwon JS. Regional Differences in Serotonin Transporter Occupancy by Escitalopram: An [(11)C]DASB PK-PD Study. Clinical Pharmacokinetics. PMID 27557550 DOI: 10.1007/s40262-016-0444-x  1
2016 Egerton A, Valmaggia LR, Howes OD, Day F, Chaddock CA, Allen P, Winton-Brown TT, Bloomfield MA, Bhattacharyya S, Chilcott J, Lappin JM, Murray RM, McGuire P. Adversity in childhood linked to elevated striatal dopamine function in adulthood. Schizophrenia Research. PMID 27344984 DOI: 10.1016/j.schres.2016.06.005  0.92
2016 Bloomfield PS, Howes OD, Turkheimer F, Selvaraj S, Veronese M. Response to Narendran and Frankle: The Interpretation of PET Microglial Imaging in Schizophrenia. The American Journal of Psychiatry. 173: 537-8. PMID 27133411 DOI: 10.1176/appi.ajp.2016.15111417r  1
2016 Kambeitz J, Howes OD. Consistent biological findings in major depression: Results from serotonin transporter meta-analyses. Journal of Affective Disorders. 199: 171. PMID 27128823 DOI: 10.1016/j.jad.2016.04.043  0.36
2016 Madeira L, Bonoldi I, Rocchetti M, Brandizzi M, Samson C, Azis M, Queen B, Bossong M, Allen P, Perez J, Howes OD, McGuire P, Fusar-Poli P. Prevalence and implications of Truman symptoms in subjects at ultra high risk for psychosis. Psychiatry Research. 238: 270-6. PMID 27086244 DOI: 10.1016/j.psychres.2016.02.001  0.88
2016 Diggle CP, Sukoff Rizzo SJ, Popiolek M, Hinttala R, Schülke JP, Kurian MA, Carr IM, Markham AF, Bonthron DT, Watson C, Sharif SM, Reinhart V, James LC, Vanase-Frawley MA, Charych E, ... ... Howes O, et al. Biallelic Mutations in PDE10A Lead to Loss of Striatal PDE10A and a Hyperkinetic Movement Disorder with Onset in Infancy. American Journal of Human Genetics. 98: 735-43. PMID 27058446 DOI: 10.1016/j.ajhg.2016.03.015  1
2016 Madeira L, Bonoldi I, Rocchetti M, Samson C, Azis M, Queen B, Bossong M, Perez J, Stone J, Allen P, Howes OD, McGuire P, Raballo A, Fusar-Poli P, Ballerini M, et al. An initial investigation of abnormal bodily phenomena in subjects at ultra high risk for psychosis: Their prevalence and clinical implications. Comprehensive Psychiatry. 66: 39-45. PMID 26995234 DOI: 10.1016/j.comppsych.2015.12.005  1
2016 Mouchlianitis E, McCutcheon R, Howes OD. Brain-imaging studies of treatment-resistant schizophrenia: a systematic review. The Lancet. Psychiatry. PMID 26948188 DOI: 10.1016/S2215-0366(15)00540-4  1
2016 Marques TR, Natesan S, Niccolini F, Politis M, Gunn RN, Searle GE, Howes O, Rabiner EA, Kapur S. Phosphodiesterase 10A in Schizophrenia: A PET Study Using [(11)C]IMA107. The American Journal of Psychiatry. appiajp201515040518. PMID 26892941 DOI: 10.1176/appi.ajp.2015.15040518  0.52
2016 Calcia MA, Bonsall DR, Bloomfield PS, Selvaraj S, Barichello T, Howes OD. Stress and neuroinflammation: a systematic review of the effects of stress on microglia and the implications for mental illness. Psychopharmacology. PMID 26847047 DOI: 10.1007/s00213-016-4218-9  1
2016 Howes OD, Nour MM. Dopamine and the aberrant salience hypothesis of schizophrenia. World Psychiatry : Official Journal of the World Psychiatric Association (Wpa). 15: 3-4. PMID 26833595 DOI: 10.1002/wps.20276  1
2016 Gee S, Howes O. Optimising treatment of schizophrenia: the role of adjunctive fluvoxamine. Psychopharmacology. PMID 26780617 DOI: 10.1007/s00213-016-4207-z  1
2016 Fond G, Howes O. Pharmacoterrorism: the potential role of psychoactive drugs in the Paris and Tunisian attacks. Psychopharmacology. PMID 26750118 DOI: 10.1007/s00213-016-4204-2  1
2015 Iyegbe CO, Acharya A, Lally J, Gardner-Sood P, Smith LS, Smith S, Murray R, Howes O, Gaughran F. Does environmental confounding mask pleiotropic effects of a multiple sclerosis susceptibility variant on vitamin D in psychosis? Npj Schizophrenia. 1: 15036. PMID 27336042 DOI: 10.1038/npjschz.2015.36  0.56
2015 Allen P, Chaddock CA, Egerton A, Howes OD, Bonoldi I, Zelaya F, Bhattacharyya S, Murray R, McGuire P. Resting Hyperperfusion of the Hippocampus, Midbrain, and Basal Ganglia in People at High Risk for Psychosis. The American Journal of Psychiatry. appiajp201515040485. PMID 26684922 DOI: 10.1176/appi.ajp.2015.15040485  1
2015 Mouchlianitis E, Bloomfield MA, Law V, Beck K, Selvaraj S, Rasquinha N, Waldman A, Turkheimer FE, Egerton A, Stone J, Howes OD. Treatment-Resistant Schizophrenia Patients Show Elevated Anterior Cingulate Cortex Glutamate Compared to Treatment-Responsive. Schizophrenia Bulletin. PMID 26683625 DOI: 10.1093/schbul/sbv151  0.8
2015 Froudist-Walsh S, Karolis V, Caldinelli C, Brittain PJ, Kroll J, Rodríguez-Toscano E, Tesse M, Colquhoun M, Howes O, Dell'Acqua F, Thiebaut de Schotten M, Murray RM, Williams SC, Nosarti C. Very Early Brain Damage Leads to Remodeling of the Working Memory System in Adulthood: A Combined fMRI/Tractography Study. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 15787-99. PMID 26631462 DOI: 10.1523/JNEUROSCI.4769-14.2015  1
2015 Rogdaki M, Jauhar S, McCutcheon R, Howes O. Treatment-Resistant Schizophrenia in a Patient With 17q12 Duplication. Biological Psychiatry. PMID 26582588 DOI: 10.1016/j.biopsych.2015.10.001  1
2015 Turkheimer FE, Rizzo G, Bloomfield PS, Howes O, Zanotti-Fregonara P, Bertoldo A, Veronese M. The methodology of TSPO imaging with positron emission tomography. Biochemical Society Transactions. 43: 586-92. PMID 26551697 DOI: 10.1042/BST20150058  1
2015 Bloomfield PS, Selvaraj S, Veronese M, Rizzo G, Bertoldo A, Owen DR, Bloomfield MA, Bonoldi I, Kalk N, Turkheimer F, McGuire P, de Paola V, Howes OD. Microglial Activity in People at Ultra High Risk of Psychosis and in Schizophrenia: An [(11)C]PBR28 PET Brain Imaging Study. The American Journal of Psychiatry. appiajp201514101358. PMID 26472628 DOI: 10.1176/appi.ajp.2015.14101358  1
2015 Kim E, Howes OD, Park JW, Kim SN, Shin SA, Kim BH, Turkheimer FE, Lee YS, Kwon JS. Altered serotonin transporter binding potential in patients with obsessive-compulsive disorder under escitalopram treatment: [11C]DASB PET study. Psychological Medicine. 1-10. PMID 26423910 DOI: 10.1017/S0033291715001865  1
2015 Kambeitz JP, Howes OD. The serotonin transporter in depression: Meta-analysis of in vivo and post mortem findings and implications for understanding and treating depression. Journal of Affective Disorders. 186: 358-66. PMID 26281039 DOI: 10.1016/j.jad.2015.07.034  1
2015 Valmaggia LR, Byrne M, Day F, Broome MR, Johns L, Howes O, Power P, Badger S, Fusar-Poli P, McGuire PK. Duration of untreated psychosis and need for admission in patients who engage with mental health services in the prodromal phase. The British Journal of Psychiatry : the Journal of Mental Science. PMID 26045348 DOI: 10.1192/bjp.bp.114.150623  1
2015 Nour MM, Howes OD. Interpreting the neurodevelopmental hypothesis of schizophrenia in the context of normal brain development and ageing. Proceedings of the National Academy of Sciences of the United States of America. 112: E2745. PMID 25941415 DOI: 10.1073/pnas.1502170112  1
2015 Bossong MG, Mehta MA, van Berckel BN, Howes OD, Kahn RS, Stokes PR. Further human evidence for striatal dopamine release induced by administration of ∆9-tetrahydrocannabinol (THC): selectivity to limbic striatum. Psychopharmacology. 232: 2723-9. PMID 25801289 DOI: 10.1007/s00213-015-3915-0  1
2015 McCutcheon R, Beck K, Bloomfield MA, Marques TR, Rogdaki M, Howes OD. Treatment resistant or resistant to treatment? Antipsychotic plasma levels in patients with poorly controlled psychotic symptoms. Journal of Psychopharmacology (Oxford, England). 29: 892-7. PMID 25788157 DOI: 10.1177/0269881115576688  1
2015 Howes O, McCutcheon R, Stone J. Glutamate and dopamine in schizophrenia: an update for the 21st century. Journal of Psychopharmacology (Oxford, England). 29: 97-115. PMID 25586400 DOI: 10.1177/0269881114563634  1
2015 Shaikh M, Dutt A, Broome MR, Vozmediano AG, Ranlund S, Diez A, Caseiro O, Lappin J, Amankwa S, Carletti F, Fusar-Poli P, Walshe M, Hall MH, Howes O, Ellett L, et al. Sensory gating deficits in the attenuated psychosis syndrome. Schizophrenia Research. 161: 277-82. PMID 25556079 DOI: 10.1016/j.schres.2014.12.021  1
2015 Winton-Brown TT, Broome MR, Allen P, Valli I, Howes O, Garety PA, Johns LC, McGuire P. Misattributing speech and jumping to conclusions: a longitudinal study in people at high risk of psychosis. European Psychiatry : the Journal of the Association of European Psychiatrists. 30: 32-7. PMID 25511317 DOI: 10.1016/j.eurpsy.2014.09.416  1
2015 Bloomfield MA, Jauhar S, Froudist-Walsh S, Bonoldi I, Howes OD. Commentary on a study of the prevalence of mental disorders by Breslau et al. Journal of Psychiatric Research. 61: 231-2. PMID 25499560 DOI: 10.1016/j.jpsychires.2014.11.006  1
2015 Beck K, Lally J, Shergill SS, Bloomfield MA, MacCabe JH, Gaughran F, Howes OD. Prevalence of serum N-methyl-D-aspartate receptor autoantibodies in refractory psychosis. The British Journal of Psychiatry : the Journal of Mental Science. 206: 164-5. PMID 25431428 DOI: 10.1192/bjp.bp.113.142216  1
2015 Serafini G, Pompili M, Borgwardt S, Giuffra E, Howes O, Girardi P, Amore M. The role of white matter abnormalities in treatment-resistant depression: a systematic review. Current Pharmaceutical Design. 21: 1337-46. PMID 25269562  1
2015 Allen P, Chaddock CA, Egerton A, Howes OD, Barker G, Bonoldi I, Fusar-Poli P, Murray R, McGuire P. Functional outcome in people at high risk for psychosis predicted by thalamic glutamate levels and prefronto-striatal activation. Schizophrenia Bulletin. 41: 429-39. PMID 25123110 DOI: 10.1093/schbul/sbu115  1
2015 Pollak TA, Beck K, Irani SR, Howes OD, David AS, McGuire PK. Autoantibodies to central nervous system neuronal surface antigens: psychiatric symptoms and psychopharmacological implications Psychopharmacology. 1-17. DOI: 10.1007/s00213-015-4156-y  1
2014 Morgan CJ, Dodds CM, Furby H, Pepper F, Fam J, Freeman TP, Hughes E, Doeller C, King J, Howes O, Stone JM. Long-Term Heavy Ketamine Use is Associated with Spatial Memory Impairment and Altered Hippocampal Activation. Frontiers in Psychiatry. 5: 149. PMID 25538631 DOI: 10.3389/fpsyt.2014.00149  1
2014 Beck K, McCutcheon R, Bloomfield MA, Gaughran F, Reis Marques T, MacCabe J, Selvaraj S, Taylor D, Howes OD. The practical management of refractory schizophrenia--the Maudsley Treatment REview and Assessment Team service approach. Acta Psychiatrica Scandinavica. 130: 427-38. PMID 25201058 DOI: 10.1111/acps.12327  1
2014 Valmaggia LR, Day FL, Jones C, Bissoli S, Pugh C, Hall D, Bhattacharyya S, Howes O, Stone J, Fusar-Poli P, Byrne M, McGuire PK. Cannabis use and transition to psychosis in people at ultra-high risk. Psychological Medicine. 44: 2503-12. PMID 25055169 DOI: 10.1017/S0033291714000117  1
2014 Kambeitz J, Abi-Dargham A, Kapur S, Howes OD. Alterations in cortical and extrastriatal subcortical dopamine function in schizophrenia: systematic review and meta-analysis of imaging studies. The British Journal of Psychiatry : the Journal of Mental Science. 204: 420-9. PMID 25029687 DOI: 10.1192/bjp.bp.113.132308  1
2014 Howes OD, Kapur S. A neurobiological hypothesis for the classification of schizophrenia: type A (hyperdopaminergic) and type B (normodopaminergic). The British Journal of Psychiatry : the Journal of Mental Science. 205: 1-3. PMID 24986384 DOI: 10.1192/bjp.bp.113.138578  1
2014 Selvaraj S, Arnone D, Cappai A, Howes O. Alterations in the serotonin system in schizophrenia: a systematic review and meta-analysis of postmortem and molecular imaging studies. Neuroscience and Biobehavioral Reviews. 45: 233-45. PMID 24971825 DOI: 10.1016/j.neubiorev.2014.06.005  1
2014 Bonoldi I, Howes OD. Presynaptic dopaminergic function: implications for understanding treatment response in psychosis. Cns Drugs. 28: 649-63. PMID 24919790 DOI: 10.1007/s40263-014-0177-z  1
2014 Egerton A, Stone JM, Chaddock CA, Barker GJ, Bonoldi I, Howard RM, Merritt K, Allen P, Howes OD, Murray RM, McLean MA, Lythgoe DJ, O'Gorman RL, McGuire PK. Relationship between brain glutamate levels and clinical outcome in individuals at ultra high risk of psychosis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2891-9. PMID 24917199 DOI: 10.1038/npp.2014.143  1
2014 Selvaraj S, Mouchlianitis E, Faulkner P, Turkheimer F, Cowen PJ, Roiser JP, Howes O. Presynaptic Serotoninergic Regulation of Emotional Processing: A Multimodal Brain Imaging Study. Biological Psychiatry. PMID 24882568 DOI: 10.1016/j.biopsych.2014.04.011  1
2014 Riaño Barros DA, McGinnity CJ, Rosso L, Heckemann RA, Howes OD, Brooks DJ, Duncan JS, Turkheimer FE, Koepp MJ, Hammers A. Test-retest reproducibility of cannabinoid-receptor type 1 availability quantified with the PET ligand [¹¹C]MePPEP. Neuroimage. 97: 151-62. PMID 24736184 DOI: 10.1016/j.neuroimage.2014.04.020  1
2014 Bloomfield MA, Pepper F, Egerton A, Demjaha A, Tomasi G, Mouchlianitis E, Maximen L, Veronese M, Turkheimer F, Selvaraj S, Howes OD. Dopamine function in cigarette smokers: an [¹⁸F]-DOPA PET study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 39: 2397-404. PMID 24718373 DOI: 10.1038/npp.2014.87  1
2014 Bloomfield MA, Morgan CJ, Kapur S, Curran HV, Howes OD. The link between dopamine function and apathy in cannabis users: an [18F]-DOPA PET imaging study. Psychopharmacology. 231: 2251-9. PMID 24696078 DOI: 10.1007/s00213-014-3523-4  1
2014 Selvaraj S, Turkheimer F, Howes O. Dopamine transporter imaging: nonindependence of regional measures. Molecular Psychiatry. 19: 964. PMID 24589891 DOI: 10.1038/mp.2014.15  1
2014 Howes O. Cognitive therapy: at last an alternative to antipsychotics? Lancet. 383: 1364-6. PMID 24508319 DOI: 10.1016/S0140-6736(13)62569-6  1
2014 Rizzo G, Veronese M, Heckemann RA, Selvaraj S, Howes OD, Hammers A, Turkheimer FE, Bertoldo A. The predictive power of brain mRNA mappings for in vivo protein density: a positron emission tomography correlation study. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 34: 827-35. PMID 24496175 DOI: 10.1038/jcbfm.2014.21  1
2014 Faulkner P, Selvaraj S, Pine A, Howes OD, Roiser JP. The relationship between reward and punishment processing and the 5-HT1A receptor as shown by PET. Psychopharmacology. 231: 2579-86. PMID 24429872 DOI: 10.1007/s00213-013-3426-9  1
2014 Goghari VM, Brett C, Tabraham P, Johns L, Valmaggia L, Broome M, Woolley J, Bramon E, Howes O, Byrne M, McGuire P. Spatial working memory ability in individuals at ultra high risk for psychosis. Journal of Psychiatric Research. 50: 100-5. PMID 24398256 DOI: 10.1016/j.jpsychires.2013.12.010  1
2014 Winton-Brown TT, Fusar-Poli P, Ungless MA, Howes OD. Dopaminergic basis of salience dysregulation in psychosis. Trends in Neurosciences. 37: 85-94. PMID 24388426 DOI: 10.1016/j.tins.2013.11.003  1
2014 Williams MR, Galvin K, O'Sullivan B, MacDonald CD, Ching EW, Turkheimer F, Howes OD, Pearce RK, Hirsch SR, Maier M. Neuropathological changes in the substantia nigra in schizophrenia but not depression. European Archives of Psychiatry and Clinical Neuroscience. 264: 285-96. PMID 24374935 DOI: 10.1007/s00406-013-0479-z  1
2014 Mondelli V, Howes O. Inflammation: its role in schizophrenia and the potential anti-inflammatory effects of antipsychotics. Psychopharmacology. 231: 317-8. PMID 24337065 DOI: 10.1007/s00213-013-3383-3  1
2014 Howes OD, Murray RM. Schizophrenia: an integrated sociodevelopmental-cognitive model. Lancet. 383: 1677-87. PMID 24315522 DOI: 10.1016/S0140-6736(13)62036-X  1
2014 Stone JM, Pepper F, Fam J, Furby H, Hughes E, Morgan C, Howes OD. Glutamate, N-acetyl aspartate and psychotic symptoms in chronic ketamine users. Psychopharmacology. 231: 2107-16. PMID 24264567 DOI: 10.1007/s00213-013-3354-8  1
2014 Stokes PR, Benecke A, Puraite J, Bloomfield MA, Shotbolt P, Reeves SJ, Lingford-Hughes AR, Howes O, Egerton A. Does human presynaptic striatal dopamine function predict social conformity? Journal of Psychopharmacology (Oxford, England). 28: 237-43. PMID 24257812 DOI: 10.1177/0269881113512037  1
2014 Gee S, Vergunst F, Howes O, Taylor D. Practitioner attitudes to clozapine initiation. Acta Psychiatrica Scandinavica. 130: 16-24. PMID 24004162 DOI: 10.1111/acps.12193  1
2014 Demjaha A, Egerton A, Murray RM, Kapur S, Howes OD, Stone JM, McGuire PK. Antipsychotic treatment resistance in schizophrenia associated with elevated glutamate levels but normal dopamine function. Biological Psychiatry. 75: e11-3. PMID 23890739 DOI: 10.1016/j.biopsych.2013.06.011  1
2014 Bloomfield MA, Morgan CJ, Egerton A, Kapur S, Curran HV, Howes OD. Dopaminergic function in cannabis users and its relationship to cannabis-induced psychotic symptoms. Biological Psychiatry. 75: 470-8. PMID 23820822 DOI: 10.1016/j.biopsych.2013.05.027  1
2014 Demjaha A, Howes OD. Dopamine and the biology and course of treatment resistance Treatment-Refractory Schizophrenia: a Clinical Conundrum. 31-44. DOI: 10.1007/978-3-642-45257-4_3  1
2013 Kim E, Howes OD, Kapur S. Molecular imaging as a guide for the treatment of central nervous system disorders. Dialogues in Clinical Neuroscience. 15: 315-28. PMID 24174903  1
2013 Howes OD, Williams M, Ibrahim K, Leung G, Egerton A, McGuire PK, Turkheimer F. Midbrain dopamine function in schizophrenia and depression: a post-mortem and positron emission tomographic imaging study. Brain : a Journal of Neurology. 136: 3242-51. PMID 24097339 DOI: 10.1093/brain/awt264  1
2013 Crews M, Lally J, Gardner-Sood P, Howes O, Bonaccorso S, Smith S, Murray RM, Di Forti M, Gaughran F. Vitamin D deficiency in first episode psychosis: a case-control study. Schizophrenia Research. 150: 533-7. PMID 24060571 DOI: 10.1016/j.schres.2013.08.036  1
2013 Bonoldi I, Howes OD. The enduring centrality of dopamine in the pathophysiology of schizophrenia: in vivo evidence from the prodrome to the first psychotic episode. Advances in Pharmacology (San Diego, Calif.). 68: 199-220. PMID 24054146 DOI: 10.1016/B978-0-12-411512-5.00010-5  1
2013 Howes OD, Beck K. Mind the mortality gap: the importance of metabolic function in mental illnesses. Psychopharmacology. 230: 1-2. PMID 24005530 DOI: 10.1007/s00213-013-3259-6  1
2013 Howes OD, Gee S, Taylor D. Authors' reply. The British Journal of Psychiatry : the Journal of Mental Science. 202: 238. PMID 23869033 DOI: 10.1192/bjp.202.3.238a  1
2013 Tseng HH, Chen SH, Liu CM, Howes O, Huang YL, Hsieh MH, Liu CC, Shan JC, Lin YT, Hwu HG. Facial and prosodic emotion recognition deficits associate with specific clusters of psychotic symptoms in schizophrenia. Plos One. 8: e66571. PMID 23818944 DOI: 10.1371/journal.pone.0066571  1
2013 Beck K, Howes O. Optimising treatment of refractory schizophrenia. Psychopharmacology. 227: 373-4. PMID 23568576 DOI: 10.1007/s00213-013-3076-y  1
2013 Howes OD, Taylor D. Authors' reply. The British Journal of Psychiatry : the Journal of Mental Science. 202: 155. PMID 23495385 DOI: 10.1192/bjp.202.2.155  1
2013 Kim E, Shidahara M, Tsoumpas C, McGinnity CJ, Kwon JS, Howes OD, Turkheimer FE. Partial volume correction using structural-functional synergistic resolution recovery: comparison with geometric transfer matrix method. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 914-20. PMID 23486292 DOI: 10.1038/jcbfm.2013.29  1
2013 Egerton A, Chaddock CA, Winton-Brown TT, Bloomfield MA, Bhattacharyya S, Allen P, McGuire PK, Howes OD. Presynaptic striatal dopamine dysfunction in people at ultra-high risk for psychosis: findings in a second cohort. Biological Psychiatry. 74: 106-12. PMID 23312565 DOI: 10.1016/j.biopsych.2012.11.017  1
2013 Kim E, Howes OD, Turkheimer FE, Kim BH, Jeong JM, Kim JW, Lee JS, Jang IJ, Shin SG, Kapur S, Kwon JS. The relationship between antipsychotic D2 occupancy and change in frontal metabolism and working memory : A dual [(11)C]raclopride and [(18) F]FDG imaging study with aripiprazole. Psychopharmacology. 227: 221-9. PMID 23271192 DOI: 10.1007/s00213-012-2953-0  1
2013 Roiser JP, Howes OD, Chaddock CA, Joyce EM, McGuire P. Neural and behavioral correlates of aberrant salience in individuals at risk for psychosis. Schizophrenia Bulletin. 39: 1328-36. PMID 23236077 DOI: 10.1093/schbul/sbs147  1
2013 Stokes PR, Shotbolt P, Mehta MA, Turkheimer E, Benecke A, Copeland C, Turkheimer FE, Lingford-Hughes AR, Howes OD. Nature or nurture? Determining the heritability of human striatal dopamine function: an [18F]-DOPA PET study. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 38: 485-91. PMID 23093224 DOI: 10.1038/npp.2012.207  1
2013 Freeman TP, Morgan CJ, Pepper F, Howes OD, Stone JM, Curran HV. Associative blocking to reward-predicting cues is attenuated in ketamine users but can be modulated by images associated with drug use. Psychopharmacology. 225: 41-50. PMID 22829431 DOI: 10.1007/s00213-012-2791-0  1
2013 Mendez MA, Horder J, Myers J, Coghlan S, Stokes P, Erritzoe D, Howes O, Lingford-Hughes A, Murphy D, Nutt D. The brain GABA-benzodiazepine receptor alpha-5 subtype in autism spectrum disorder: a pilot [(11)C]Ro15-4513 positron emission tomography study. Neuropharmacology. 68: 195-201. PMID 22546616 DOI: 10.1016/j.neuropharm.2012.04.008  1
2013 Howes OD, Shotbolt P, Bloomfield M, Daalman K, Demjaha A, Diederen KM, Ibrahim K, Kim E, McGuire P, Kahn RS, Sommer IE. Dopaminergic function in the psychosis spectrum: an [18F]-DOPA imaging study in healthy individuals with auditory hallucinations. Schizophrenia Bulletin. 39: 807-14. PMID 22282457 DOI: 10.1093/schbul/sbr195  1
2013 Chen KC, Yang YK, Howes O, Lee IH, Landau S, Yeh TL, Chiu NT, Chen PS, Lu RB, David AS, Bramon E. Striatal dopamine transporter availability in drug-naive patients with schizophrenia: a case-control SPECT study with [(99m)Tc]-TRODAT-1 and a meta-analysis. Schizophrenia Bulletin. 39: 378-86. PMID 22156764 DOI: 10.1093/schbul/sbr163  1
2012 Lord LD, Allen P, Expert P, Howes O, Broome M, Lambiotte R, Fusar-Poli P, Valli I, McGuire P, Turkheimer FE. Functional brain networks before the onset of psychosis: A prospective fMRI study with graph theoretical analysis. Neuroimage. Clinical. 1: 91-8. PMID 24179741 DOI: 10.1016/j.nicl.2012.09.008  1
2012 Selvaraj S, Faulkner P, Mouchlianitis E, Roiser JP, Howes O. Effects of citalopram on serotonin neurotransmission. Molecular Psychiatry. 17: 1143. PMID 23168914 DOI: 10.1038/mp.2012.166  1
2012 Demjaha A, Murray RM, McGuire PK, Kapur S, Howes OD. Dopamine synthesis capacity in patients with treatment-resistant schizophrenia. The American Journal of Psychiatry. 169: 1203-10. PMID 23034655 DOI: 10.1176/appi.ajp.2012.12010144  1
2012 Howes OD, Vergunst F, Gee S, McGuire P, Kapur S, Taylor D. Adherence to treatment guidelines in clinical practice: study of antipsychotic treatment prior to clozapine initiation. The British Journal of Psychiatry : the Journal of Mental Science. 201: 481-5. PMID 22955007 DOI: 10.1192/bjp.bp.111.105833  1
2012 Marques TR, Smith S, Bonaccorso S, Gaughran F, Kolliakou A, Dazzan P, Mondelli V, Taylor H, Diforti M, McGuire PK, Murray RM, Howes OD. Sexual dysfunction in people with prodromal or first-episode psychosis. The British Journal of Psychiatry : the Journal of Mental Science. 201: 131-6. PMID 22700081 DOI: 10.1192/bjp.bp.111.101220  1
2012 Selvaraj S, Turkheimer F, Rosso L, Faulkner P, Mouchlianitis E, Roiser JP, McGuire P, Cowen PJ, Howes O. Measuring endogenous changes in serotonergic neurotransmission in humans: a [11C]CUMI-101 PET challenge study. Molecular Psychiatry. 17: 1254-60. PMID 22665264 DOI: 10.1038/mp.2012.78  1
2012 Fusar-Poli P, Deste G, Smieskova R, Barlati S, Yung AR, Howes O, Stieglitz RD, Vita A, McGuire P, Borgwardt S. Cognitive functioning in prodromal psychosis: a meta-analysis. Archives of General Psychiatry. 69: 562-71. PMID 22664547 DOI: 10.1001/archgenpsychiatry.2011.1592  1
2012 Reeves SJ, Polling C, Stokes PR, Lappin JM, Shotbolt PP, Mehta MA, Howes OD, Egerton A. Limbic striatal dopamine D2/3 receptor availability is associated with non-planning impulsivity in healthy adults after exclusion of potential dissimulators. Psychiatry Research. 202: 60-4. PMID 22595510 DOI: 10.1016/j.pscychresns.2011.09.011  1
2012 van Os J, Howes OD. Antipsychotic drugs for prevention of relapse. Lancet. 379: 2030-1. PMID 22560608 DOI: 10.1016/S0140-6736(12)60406-1  1
2012 Howes OD, Kambeitz J, Kim E, Stahl D, Slifstein M, Abi-Dargham A, Kapur S. The nature of dopamine dysfunction in schizophrenia and what this means for treatment. Archives of General Psychiatry. 69: 776-86. PMID 22474070 DOI: 10.1001/archgenpsychiatry.2012.169  1
2012 Fusar-Poli P, Howes O, Bechdolf A, Borgwardt S. Mapping vulnerability to bipolar disorder: a systematic review and meta-analysis of neuroimaging studies. Journal of Psychiatry & Neuroscience : Jpn. 37: 170-84. PMID 22297067 DOI: 10.1503/jpn.110061  1
2012 Allen P, Luigjes J, Howes OD, Egerton A, Hirao K, Valli I, Kambeitz J, Fusar-Poli P, Broome M, McGuire P. Transition to psychosis associated with prefrontal and subcortical dysfunction in ultra high-risk individuals. Schizophrenia Bulletin. 38: 1268-76. PMID 22290265 DOI: 10.1093/schbul/sbr194  1
2012 Valmaggia LR, McGuire PK, Fusar-Poli P, Howes O, McCrone P. Economic impact of early detection and early intervention of psychosis. Current Pharmaceutical Design. 18: 592-5. PMID 22239592 DOI: 10.2174/138161212799316145  1
2012 Howes OD, Fusar-Poli P, Bloomfield M, Selvaraj S, McGuire P. From the prodrome to chronic schizophrenia: the neurobiology underlying psychotic symptoms and cognitive impairments. Current Pharmaceutical Design. 18: 459-65. PMID 22239576 DOI: 10.2174/138161212799316217  1
2012 Crews MP, Howes OD. Is antipsychotic treatment linked to low bone mineral density and osteoporosis? A review of the evidence and the clinical implications. Human Psychopharmacology. 27: 15-23. PMID 22228316 DOI: 10.1002/hup.1265  1
2012 Masillo A, Day F, Laing J, Howes O, Fusar-Poli P, Byrne M, Bhattacharyya S, Fiori Nastro P, Girardi P, McGuire PK, Valmaggia LR. Interpersonal sensitivity in the at-risk mental state for psychosis. Psychological Medicine. 42: 1835-45. PMID 22225783 DOI: 10.1017/S0033291711002996  1
2012 Kim E, Howes OD, Kim BH, Jeong JM, Lee JS, Jang IJ, Shin SG, Turkheimer FE, Kapur S, Kwon JS. Predicting brain occupancy from plasma levels using PET: superiority of combining pharmacokinetics with pharmacodynamics while modeling the relationship. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 759-68. PMID 22186667 DOI: 10.1038/jcbfm.2011.180  1
2012 Shaikh M, Valmaggia L, Broome MR, Dutt A, Lappin J, Day F, Woolley J, Tabraham P, Walshe M, Johns L, Fusar-Poli P, Howes O, Murray RM, McGuire P, Bramon E. Reduced mismatch negativity predates the onset of psychosis. Schizophrenia Research. 134: 42-8. PMID 22024244 DOI: 10.1016/j.schres.2011.09.022  1
2012 Stokes PR, Egerton A, Watson B, Reid A, Lappin J, Howes OD, Nutt DJ, Lingford-Hughes AR. History of cannabis use is not associated with alterations in striatal dopamine D2/D3 receptor availability. Journal of Psychopharmacology (Oxford, England). 26: 144-9. PMID 21890594 DOI: 10.1177/0269881111414090  1
2012 Turkheimer FE, Selvaraj S, Hinz R, Murthy V, Bhagwagar Z, Grasby P, Howes O, Rosso L, Bose SK. Quantification of ligand PET studies using a reference region with a displaceable fraction: application to occupancy studies with [(11)C]-DASB as an example. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 70-80. PMID 21811290 DOI: 10.1038/jcbfm.2011.108  1
2012 Allen P, Chaddock CA, Howes OD, Egerton A, Seal ML, Fusar-Poli P, Valli I, Day F, McGuire PK. Abnormal relationship between medial temporal lobe and subcortical dopamine function in people with an ultra high risk for psychosis. Schizophrenia Bulletin. 38: 1040-9. PMID 21536784 DOI: 10.1093/schbul/sbr017  1
2012 Broome MR, Day F, Valli I, Valmaggia L, Johns LC, Howes O, Garety P, McGuire PK. Delusional ideation, manic symptomatology and working memory in a cohort at clinical high-risk for psychosis: a longitudinal study. European Psychiatry : the Journal of the Association of European Psychiatrists. 27: 258-63. PMID 20934858 DOI: 10.1016/j.eurpsy.2010.07.008  1
2012 Howes O. Molecular imaging in schizophrenia Neuromethods. 71: 305-321. DOI: 10.1007/7657-2012-57  1
2011 McGuire P, Selvaraj S, Howes O. Is clinical intervention in the ultra high risk phase effective? Revista Brasileira De Psiquiatria (SãO Paulo, Brazil : 1999). 33: s161-74. PMID 22286566 DOI: 10.1590/S1516-44462011000600004  1
2011 Howes OD, Falkenberg I. Early detection and intervention in bipolar affective disorder: targeting the development of the disorder. Current Psychiatry Reports. 13: 493-9. PMID 21850462 DOI: 10.1007/s11920-011-0229-8  1
2011 Howes OD, Bose SK, Turkheimer F, Valli I, Egerton A, Valmaggia LR, Murray RM, McGuire P. Dopamine synthesis capacity before onset of psychosis: a prospective [18F]-DOPA PET imaging study. The American Journal of Psychiatry. 168: 1311-7. PMID 21768612 DOI: 10.1176/appi.ajp.2011.11010160  1
2011 Bose SK, Mehta MA, Selvaraj S, Howes OD, Hinz R, Rabiner EA, Grasby PM, Turkheimer FE, Murthy V. Presynaptic 5-HT1A is related to 5-HTT receptor density in the human brain. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 2258-65. PMID 21750580 DOI: 10.1038/npp.2011.113  1
2011 Kim E, Howes OD, Yu KS, Jeong JM, Lee JS, Jang IJ, Shin SG, Kapur S, Kwon JS. Calculating occupancy when one does not have baseline: a comparison of different options. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 1760-7. PMID 21522162 DOI: 10.1038/jcbfm.2011.54  1
2011 Kim E, Howes OD, Kim BH, Yu KS, Jeong JM, Lee JS, Kim SJ, Jang IJ, Park JS, Kim YG, Shin SG, Turkheimer FE, Kapur S, Kwon JS. The use of healthy volunteers instead of patients to inform drug dosing studies: a [¹¹C]raclopride PET study. Psychopharmacology. 217: 515-23. PMID 21503604 DOI: 10.1007/s00213-011-2306-4  1
2011 Shotbolt P, Stokes PR, Owens SF, Toulopoulou T, Picchioni MM, Bose SK, Murray RM, Howes OD. Striatal dopamine synthesis capacity in twins discordant for schizophrenia. Psychological Medicine. 41: 2331-8. PMID 21426628 DOI: 10.1017/S0033291711000341  1
2011 Howes O, Bose S, Turkheimer F, Valli I, Egerton A, Stahl D, Valmaggia L, Allen P, Murray R, McGuire P. Progressive increase in striatal dopamine synthesis capacity as patients develop psychosis: a PET study. Molecular Psychiatry. 16: 885-6. PMID 21358709 DOI: 10.1038/mp.2011.20  1
2011 Lord LD, Allen P, Expert P, Howes O, Lambiotte R, McGuire P, Bose SK, Hyde S, Turkheimer FE. Characterization of the anterior cingulate's role in the at-risk mental state using graph theory. Neuroimage. 56: 1531-9. PMID 21316462 DOI: 10.1016/j.neuroimage.2011.02.012  1
2011 Selvaraj S, Godlewska BR, Norbury R, Bose S, Turkheimer F, Stokes P, Rhodes R, Howes O, Cowen PJ. Decreased regional gray matter volume in S' allele carriers of the 5-HTTLPR triallelic polymorphism. Molecular Psychiatry. 16: 471, 472-3. PMID 21042318 DOI: 10.1038/mp.2010.112  1
2011 Howes OD, Lim S, Theologos G, Yung AR, Goodwin GM, McGuire P. A comprehensive review and model of putative prodromal features of bipolar affective disorder. Psychological Medicine. 41: 1567-77. PMID 20836910 DOI: 10.1017/S0033291710001790  1
2011 Fusar-Poli P, Howes OD, Allen P, Broome M, Valli I, Asselin MC, Montgomery AJ, Grasby PM, McGuire P. Abnormal prefrontal activation directly related to pre-synaptic striatal dopamine dysfunction in people at clinical high risk for psychosis. Molecular Psychiatry. 16: 67-75. PMID 19949389 DOI: 10.1038/mp.2009.108  1
2011 Egerton A, Borgwardt SJ, Tognin S, Howes OD, McGuire P, Allen P. An overview of functional, structural and neurochemical imaging studies in individuals with a clinical high risk for psychosis Neuropsychiatry. 1: 477-493. DOI: 10.2217/npy.11.51  1
2011 Stone JM, Howes OD, Egerton A, Kambeitz J, Allen P, Lythgoe DJ, O'Gorman RL, McLean MA, Barker GJ, McGuire P. Reply to: Hippocampal glutamate levels and striatal dopamine D 2/3 receptor occupancy in subjects at ultra high risk of psychosis Biological Psychiatry. 70: e3-e4. DOI: 10.1016/j.biopsych.2011.01.039  1
2010 Stansby G, Noble S, Howes O. The importance of venous thromboembolism - a physical consequence of psychiatric treatments. International Journal of Clinical Practice. 64: 1005-6. PMID 20642699 DOI: 10.1111/j.1742-1241.2010.02435.x  1
2010 Stone JM, Howes OD, Egerton A, Kambeitz J, Allen P, Lythgoe DJ, O'Gorman RL, McLean MA, Barker GJ, McGuire P. Altered relationship between hippocampal glutamate levels and striatal dopamine function in subjects at ultra high risk of psychosis. Biological Psychiatry. 68: 599-602. PMID 20638047 DOI: 10.1016/j.biopsych.2010.05.034  1
2010 Fusar-Poli P, Howes OD, Allen P, Broome M, Valli I, Asselin MC, Grasby PM, McGuire PK. Abnormal frontostriatal interactions in people with prodromal signs of psychosis: a multimodal imaging study. Archives of General Psychiatry. 67: 683-91. PMID 20603449 DOI: 10.1001/archgenpsychiatry.2010.77  1
2010 Egerton A, Demjaha A, McGuire P, Mehta MA, Howes OD. The test-retest reliability of 18F-DOPA PET in assessing striatal and extrastriatal presynaptic dopaminergic function. Neuroimage. 50: 524-31. PMID 20034580 DOI: 10.1016/j.neuroimage.2009.12.058  1
2010 Egerton A, Shotbolt JP, Stokes PR, Hirani E, Ahmad R, Lappin JM, Reeves SJ, Mehta MA, Howes OD, Grasby PM. Acute effect of the anti-addiction drug bupropion on extracellular dopamine concentrations in the human striatum: an [11C]raclopride PET study. Neuroimage. 50: 260-6. PMID 19969097 DOI: 10.1016/j.neuroimage.2009.11.077  1
2010 Egerton A, Hirani E, Ahmad R, Turton DR, Brickute D, Rosso L, Howes OD, Luthra SK, Grasby PM. Further evaluation of the carbon11-labeled D(2/3) agonist PET radiotracer PHNO: reproducibility in tracer characteristics and characterization of extrastriatal binding. Synapse (New York, N.Y.). 64: 301-12. PMID 19957364 DOI: 10.1002/syn.20718  1
2010 Johns LC, Allen P, Valli I, Winton-Brown T, Broome M, Woolley J, Tabraham P, Day F, Howes O, Wykes T, McGuire P. Impaired verbal self-monitoring in individuals at high risk of psychosis. Psychological Medicine. 40: 1433-42. PMID 19951449 DOI: 10.1017/S0033291709991991  1
2010 Howes OD, Lim SJ, Fusar-Poli P. Mind the translation gap: problems in the implementation of early intervention services. Psychological Medicine. 40: 171-2. PMID 19732484 DOI: 10.1017/S0033291709991127  1
2010 Murray RM, Forti MD, Howes O. Integrating the epidemiology and pathogenesis of schizophrenia from the street to the striatum: Integrating the epidemiology and pathogenesis of schizophrenia Advances in Schizophrenia Research 2009. 357-366. DOI: 10.1007/978-1-4419-0913-8_19  1
2009 Fusar-Poli P, Howes O, Borgwardt S. Johann Cristian Reil on the 200th anniversary of the first description of the insula (1809). Journal of Neurology, Neurosurgery, and Psychiatry. 80: 1409. PMID 19917825 DOI: 10.1136/jnnp.2009.185884  1
2009 Howes OD, Egerton A, Allan V, McGuire P, Stokes P, Kapur S. Mechanisms underlying psychosis and antipsychotic treatment response in schizophrenia: insights from PET and SPECT imaging. Current Pharmaceutical Design. 15: 2550-9. PMID 19689327 DOI: 10.2174/138161209788957528  1
2009 Fusar-Poli P, Howes OD, McGuire P. Pseudohallucinations versus true hallucinations in prodromal psychosis: does it really matter? The Journal of Clinical Psychiatry. 70: 1056-7. PMID 19653984 DOI: 10.4088/JCP.08l04848  1
2009 Howes OD, Hundal H. Sex hormone augmentation as an adjunctive treatment in schizophrenia. Journal of Clinical Psychopharmacology. 29: 195-6; author reply . PMID 19512993 DOI: 10.1097/JCP.0b013e31819a6c92  1
2009 Egerton A, Mehta MA, Montgomery AJ, Lappin JM, Howes OD, Reeves SJ, Cunningham VJ, Grasby PM. The dopaminergic basis of human behaviors: A review of molecular imaging studies. Neuroscience and Biobehavioral Reviews. 33: 1109-32. PMID 19481108 DOI: 10.1016/j.neubiorev.2009.05.005  1
2009 Bose SK, Mackinnon T, Mehta MA, Turkheimer FE, Howes OD, Selvaraj S, Kempton MJ, Grasby PM. The effect of ageing on grey and white matter reductions in schizophrenia. Schizophrenia Research. 112: 7-13. PMID 19450953 DOI: 10.1016/j.schres.2009.04.023  1
2009 Howes OD, Khambhaita A, Fusar-Poli P. Julius Wagner-Jauregg, 1857-1940. The American Journal of Psychiatry. 166: 409. PMID 19339366 DOI: 10.1176/appi.ajp.2008.08081271  1
2009 Howes OD, Kapur S. The dopamine hypothesis of schizophrenia: version III--the final common pathway. Schizophrenia Bulletin. 35: 549-62. PMID 19325164 DOI: 10.1093/schbul/sbp006  1
2009 Egerton A, McGuire PK, Howes OD. Functionally defined regions may aid interpretation of striatal dopamine elevation in schizophrenia. Schizophrenia Research. 109: 200. PMID 19250801 DOI: 10.1016/j.schres.2009.02.004  1
2009 Howes OD, Montgomery AJ, Asselin MC, Murray RM, Valli I, Tabraham P, Bramon-Bosch E, Valmaggia L, Johns L, Broome M, McGuire PK, Grasby PM. Elevated striatal dopamine function linked to prodromal signs of schizophrenia. Archives of General Psychiatry. 66: 13-20. PMID 19124684 DOI: 10.1001/archgenpsychiatry.2008.514  1
2009 Prata DP, Mechelli A, Fu CH, Picchioni M, Kane F, Kalidindi S, McDonald C, Howes O, Kravariti E, Demjaha A, Toulopoulou T, Diforti M, Murray RM, Collier DA, McGuire PK. Opposite effects of catechol-O-methyltransferase Val158Met on cortical function in healthy subjects and patients with schizophrenia. Biological Psychiatry. 65: 473-80. PMID 19054502 DOI: 10.1016/j.biopsych.2008.09.027  1
2009 Fusar-Poli P, Howes O, Valli I, Allen P, Broome M, Grasby P, McGuire P. Multimodal functional imaging investigation before and after the onset of psychosis. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 12: 579-81. PMID 18925982 DOI: 10.1017/S146114570800953X  1
2009 Howes OD, Mcguire PK, Kapur S. Understanding pathophysiology is crucial in linking clinical staging to targeted therapeutics | Zrozumienie patofizjologii kluczem do powiazania stadiów klinicznych z ukierunkowana farmakoterapia Postepy Psychiatrii I Neurologii. 18: 19-21.  1
2008 Bose SK, Turkheimer FE, Howes OD, Mehta MA, Cunliffe R, Stokes PR, Grasby PM. Classification of schizophrenic patients and healthy controls using [18F] fluorodopa PET imaging. Schizophrenia Research. 106: 148-55. PMID 18849151 DOI: 10.1016/j.schres.2008.09.011  1
2008 Howes OD, McGuire PK, Kapur S. Understanding pathophysiology is crucial in linking clinical staging to targeted therapeutics. World Psychiatry : Official Journal of the World Psychiatric Association (Wpa). 7: 162-3. PMID 18836539  1
2008 Fusar-Poli P, Howes O, Valmaggia L, McGuire P. 'Truman' signs and vulnerability to psychosis. The British Journal of Psychiatry : the Journal of Mental Science. 193: 168. PMID 18670010 DOI: 10.1192/bjp.193.2.168  1
2008 Bramon E, Shaikh M, Broome M, Lappin J, Bergé D, Day F, Woolley J, Tabraham P, Madre M, Johns L, Howes O, Valmaggia L, Pérez V, Sham P, Murray RM, et al. Abnormal P300 in people with high risk of developing psychosis. Neuroimage. 41: 553-60. PMID 18387827 DOI: 10.1016/j.neuroimage.2007.12.038  1
2008 McGuire P, Howes OD, Stone J, Fusar-Poli P. Functional neuroimaging in schizophrenia: diagnosis and drug discovery Trends in Pharmacological Sciences. 29: 91-98. PMID 18187211 DOI: 10.1016/j.tips.2007.11.005  1
2007 Howes OD, Weinstein S, Tabraham P, Valmaggia L, Broome M, McGuire P. Slang and schizophrenia British Medical Journal. 335: 1294. PMID 18156234  1
2007 Howes OD, Montgomery AJ, Asselin MC, Murray RM, Grasby PM, McGuire PK. Molecular imaging studies of the striatal dopaminergic system in psychosis and predictions for the prodromal phase of psychosis. The British Journal of Psychiatry. Supplement. 51: s13-8. PMID 18055930 DOI: 10.1192/bjp.191.51.s13  1
2007 Howes OD, Wheeler MJ, Pilowsky LS, Landau S, Murray RM, Smith S. Sexual function and gonadal hormones in patients taking antipsychotic treatment for schizophrenia or schizoaffective disorder Journal of Clinical Psychiatry. 68: 361-367. PMID 17388704  1
2007 Asselin MC, Howes OD, Osman S, Yau K, Stokes PR, Grasby PM. Increases in striatal FDOPA influx constants in UHRP patients are not due to changes in plasma OMFD concentrations Journal of Cerebral Blood Flow and Metabolism. 27: PO01-03M.  1
2006 Howes OD, Smith S, Gaughran FP, Amiel SA, Murray RM, Pilowsky LS. The relationship between prolactin levels and glucose homeostasis in antipsychotic-treated schizophrenic patients Journal of Clinical Psychopharmacology. 26: 629-631. PMID 17110820 DOI: 10.1097/01.jcp.0000239791.91330.48  1
2006 Howes OD. Compulsions in depression: Stalking by text message [1] American Journal of Psychiatry. 163: 1642. PMID 16946195  1
2005 Howes OD, Smith S, Aitchison KJ. Comments on "Prolactin levels and erectile function in patients treated with risperidone" (J Clin Psychopharmacol 2004;24:161-166). Journal of Clinical Psychopharmacology. 25: 393-4. PMID 16012288 DOI: 10.1097/01.jcp.0000170033.78060.84  1
2005 Howes OD, Wheeler MJ, Meaney AM, O'Keane V, Fogelman I, Blake G, Murray RM, Smith S. Bone mineral density and its relationship to prolactin levels in patients taking antipsychotic treatment Journal of Clinical Psychopharmacology. 25: 259-261. PMID 15876906 DOI: 10.1097/01.jcp.0000162798.87249.4d  1
2005 Gaughran F, Chrisman L, Howes OD, Vincent A. Serum glutamic acid decarboxylase 65 antibody levels in people with schizophrenia and their families [5] Schizophrenia Research. 73: 379-381. PMID 15653287 DOI: 10.1016/j.schres.2004.05.004  1
2004 Howes OD, Gaughran FP, Amiel SA, Murray RM, Pilowsky LS. The effect of clozapine on factors controlling glucose homeostasis Journal of Clinical Psychiatry. 65: 1352-1355. PMID 15491238 DOI: 10.4088/JCP.v65n1009  1
2004 Howes OD, Smith S, Aitchison KJ. Comment on Hyperprolactinaemia and antipsychotic therapy in schizophrenia. Current Medical Research and Opinion. 20: 1649. PMID 15462698 DOI: 10.1185/030079904X4941  1
2004 Howes OD, Rifkin L. Diabetic keto-acidotic (DKA) coma following olanzapine initiation in a previously euglycaemic woman and successful continued therapy with olanzapine Journal of Psychopharmacology. 18: 435-437. PMID 15358991 DOI: 10.1177/026988110401800317  1
2004 Meaney AM, Smith S, Howes OD, O'Brien M, Murray RM, O'Keane V. Effects of long-term prolactin-raising antipsychotic medication an bone mineral density in patients with schizophrenia British Journal of Psychiatry. 184: 503-508. PMID 15172944 DOI: 10.1192/bjp.184.6.503  1
2004 Howes O, Smith S. Alendronic Acid for Antipsychotic-Related Osteopenia [1] American Journal of Psychiatry. 161: 756. PMID 15056528  1
2004 Howes OD, McDonald C, Cannon M, Arseneault L, Boydell J, Murray RM. Pathways to schizophrenia: The impact of environmental factors International Journal of Neuropsychopharmacology. 7: S7-S13. PMID 14972079 DOI: 10.1017/S1461145704004122  1
2004 Howes OD, Bhatnagar A, Gaughran FP, Amiel SA, Murray RM, Pilowsky LS. A Prospective Study of Impairment in Glucose Control Caused by Clozapine Without Changes in Insulin Resistance American Journal of Psychiatry. 161: 361-363. PMID 14754788 DOI: 10.1176/appi.ajp.161.2.361  1
2004 Howes O. Bone mineral density and prolactin associations in patients with chronic schizophrenia [3] Schizophrenia Research. 66: 77-78. PMID 14693356 DOI: 10.1016/S0920-9964(03)00054-9  1
2003 Howes O, Ohlsen R, Pilowsky LS. Effect of clozapine on mortality [3] British Journal of Psychiatry. 183: 460. PMID 14594927 DOI: 10.1192/bjp.183.5.460  1
2002 Howes O, Smith S, Winning S. Hyperprolactinaemia caused by antipsychotic drugs: Endocrine antipsychotic side effects must be systematically assessed [5] (multiple letters) British Medical Journal. 324: 1278-1279. PMID 12028991  1
2000 Howes OD, Mckenzie KJ. Manic psychosis induced by long term alpha-interferon treatment for hepatitis C International Journal of Psychiatry in Clinical Practice. 4: 161-162.  1
1998 Howes OD, Salkovskis PM. Health anxiety in medical students Lancet. 351: 1332. PMID 9643804 DOI: 10.1016/S0140-6736(05)79059-0  1
1998 Howes O. Environmentally friendly health care begins in Madagascar Lancet. 351: 577. PMID 9492793  1
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