Wayne Michael Patrick - Publications

University of Victoria, Victoria, British Columbia, Canada 

35 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Brewster JL, Pachl P, McKellar JLO, Selmer M, Squire CJ, Patrick WM. Structures and kinetics of Thermotoga maritima MetY reveal new insights into the predominant sulfurylation enzyme of bacterial methionine biosynthesis. The Journal of Biological Chemistry. 100797. PMID 34019879 DOI: 10.1016/j.jbc.2021.100797  0.336
2021 Vickers CJ, Fraga D, Patrick WM. Quantifying the taxonomic bias in enzymology. Protein Science : a Publication of the Protein Society. PMID 33583070 DOI: 10.1002/pro.4041  0.311
2020 Hall KR, Robins KJ, Williams EM, Rich MH, Calcott MJ, Copp JN, Little RF, Schwörer R, Evans GB, Patrick WM, Ackerley DF. Intracellular complexities of acquiring a new enzymatic function revealed by mass-randomisation of active site residues. Elife. 9. PMID 33185191 DOI: 10.7554/eLife.59081  0.318
2020 Söderholm A, Newton MS, Patrick WM, Selmer M. Structure and kinetics of indole-3-glycerol phosphate synthase from - decarboxylation is not essential for indole formation. The Journal of Biological Chemistry. PMID 32928960 DOI: 10.1074/jbc.RA120.014936  0.315
2019 Wardell SJT, Rehman A, Martin LW, Winstanley C, Patrick WM, Lamont IL. A large-scale whole-genome comparison shows that experimental evolution in response to antibiotics predicts changes in naturally evolved clinical . Antimicrobial Agents and Chemotherapy. PMID 31570397 DOI: 10.1128/Aac.01619-19  0.324
2019 Rehman A, Patrick WM, Lamont IL. Mechanisms of ciprofloxacin resistance in Pseudomonas aeruginosa: new approaches to an old problem. Journal of Medical Microbiology. 68: 1-10. PMID 30605076 DOI: 10.1099/Jmm.0.000873  0.314
2017 Newton MS, Arcus VL, Gerth ML, Patrick WM. Enzyme evolution: innovation is easy, optimization is complicated. Current Opinion in Structural Biology. 48: 110-116. PMID 29207314 DOI: 10.1016/J.Sbi.2017.11.007  0.444
2017 Maddock DJ, Gerth ML, Patrick WM. An engineered glycerol dehydratase with improved activity for the conversion of meso-2,3-butanediol to butanone. Biotechnology Journal. PMID 28881100 DOI: 10.1002/Biot.201700480  0.398
2017 Ferla MP, Brewster JL, Hall KR, Evans GB, Patrick WM. Primordial-like enzymes from bacteria with reduced genomes. Molecular Microbiology. PMID 28640457 DOI: 10.1111/Mmi.13737  0.671
2017 Newton MS, Guo X, Söderholm A, Näsvall J, Lundström P, Andersson DI, Selmer M, Patrick WM. Structural and functional innovations in the real-time evolution of new (βα)8 barrel enzymes. Proceedings of the National Academy of Sciences of the United States of America. PMID 28416687 DOI: 10.1073/Pnas.1618552114  0.448
2016 Soo VW, Yosaatmadja Y, Squire CJ, Patrick WM. Mechanistic and Evolutionary Insights from the Reciprocal Promiscuity of Two Pyridoxal Phosphate-Dependent Enzymes. The Journal of Biological Chemistry. PMID 27474741 DOI: 10.1074/Jbc.M116.739557  0.443
2016 Newton MS, Guo X, Söderholm A, Näsvall J, Lundström P, Andersson DI, Selmer M, Patrick WM. Structural and functional innovations in the real-time evolution of new ( beta alpha )8 barrel enzymes. Proceedings of the National Academy of Sciences of the United States of America. 114: 4727-4732. DOI: 10.2210/Pdb5Ab3/Pdb  0.366
2015 Söderholm A, Guo X, Newton MS, Evans GB, Näsvall J, Patrick WM, Selmer M. Two-step Ligand Binding in a (βα)8 Barrel Enzyme: SUBSTRATE-BOUND STRUCTURES SHED NEW LIGHT ON THE CATALYTIC CYCLE OF HisA. The Journal of Biological Chemistry. 290: 24657-68. PMID 26294764 DOI: 10.1074/Jbc.M115.678086  0.392
2015 Maddock DJ, Patrick WM, Gerth ML. Substitutions at the cofactor phosphate-binding site of a clostridial alcohol dehydrogenase lead to unexpected changes in substrate specificity. Protein Engineering, Design & Selection : Peds. 28: 251-8. PMID 26034298 DOI: 10.1093/Protein/Gzv028  0.428
2015 Newton MS, Arcus VL, Patrick WM. Rapid bursts and slow declines: on the possible evolutionary trajectories of enzymes. Journal of the Royal Society, Interface / the Royal Society. 12. PMID 25926697 DOI: 10.1098/Rsif.2015.0036  0.423
2014 Patrick WM, Gerth ML. ITCHY: Incremental Truncation for the Creation of Hybrid enzYmes. Methods in Molecular Biology (Clifton, N.J.). 1179: 225-44. PMID 25055782 DOI: 10.1007/978-1-4939-1053-3_16  0.401
2014 Copp JN, Hanson-Manful P, Ackerley DF, Patrick WM. Error-prone PCR and effective generation of gene variant libraries for directed evolution. Methods in Molecular Biology (Clifton, N.J.). 1179: 3-22. PMID 25055767 DOI: 10.1007/978-1-4939-1053-3_1  0.411
2014 Ferla MP, Patrick WM. Bacterial methionine biosynthesis. Microbiology (Reading, England). 160: 1571-84. PMID 24939187 DOI: 10.1099/Mic.0.077826-0  0.666
2014 Köpke M, Gerth ML, Maddock DJ, Mueller AP, Liew F, Simpson SD, Patrick WM. Reconstruction of an acetogenic 2,3-butanediol pathway involving a novel NADPH-dependent primary-secondary alcohol dehydrogenase. Applied and Environmental Microbiology. 80: 3394-403. PMID 24657865 DOI: 10.1128/Aem.00301-14  0.343
2013 Ferla MP, Thrash JC, Giovannoni SJ, Patrick WM. New rRNA gene-based phylogenies of the Alphaproteobacteria provide perspective on major groups, mitochondrial ancestry and phylogenetic instability. Plos One. 8: e83383. PMID 24349502 DOI: 10.1371/Journal.Pone.0083383  0.644
2013 Hanson-Manful P, Patrick WM. Construction and analysis of randomized protein-encoding libraries using error-prone PCR. Methods in Molecular Biology (Clifton, N.J.). 996: 251-67. PMID 23504429 DOI: 10.1007/978-1-62703-354-1_15  0.374
2012 Gerth ML, Nigon LV, Patrick WM. Characterization of the indole-3-glycerol phosphate synthase from Pseudomonas aeruginosa PAO1. The Protein Journal. 31: 359-65. PMID 22555873 DOI: 10.1007/S10930-012-9412-Y  0.364
2011 Setiyaputra S, Mackay JP, Patrick WM. The structure of a truncated phosphoribosylanthranilate isomerase suggests a unified model for evolution of the (βα)8 barrel fold. Journal of Molecular Biology. 408: 291-303. PMID 21354426 DOI: 10.1016/J.Jmb.2011.02.048  0.385
2011 Soo VW, Hanson-Manful P, Patrick WM. Artificial gene amplification reveals an abundance of promiscuous resistance determinants in Escherichia coli. Proceedings of the National Academy of Sciences of the United States of America. 108: 1484-9. PMID 21173244 DOI: 10.1073/Pnas.1012108108  0.406
2010 Patrick WM, Nakatani Y, Cutfield SM, Sharpe ML, Ramsay RJ, Cutfield JF. Carbohydrate binding sites in Candida albicans exo-β-1,3-glucanase and the role of the Phe-Phe 'clamp' at the active site entrance Febs Journal. 277: 4549-4561. PMID 20875088 DOI: 10.1111/J.1742-4658.2010.07869.X  0.63
2008 Firth AE, Patrick WM. GLUE-IT and PEDEL-AA: new programmes for analyzing protein diversity in randomized libraries. Nucleic Acids Research. 36: W281-5. PMID 18442989 DOI: 10.1093/Nar/Gkn226  0.321
2008 Patrick WM, Matsumura I. A study in molecular contingency: glutamine phosphoribosylpyrophosphate amidotransferase is a promiscuous and evolvable phosphoribosylanthranilate isomerase. Journal of Molecular Biology. 377: 323-36. PMID 18272177 DOI: 10.1016/J.Jmb.2008.01.043  0.433
2007 Patrick WM, Quandt EM, Swartzlander DB, Matsumura I. Multicopy suppression underpins metabolic evolvability. Molecular Biology and Evolution. 24: 2716-22. PMID 17884825 DOI: 10.1093/Molbev/Msm204  0.449
2006 O'Loughlin TL, Patrick WM, Matsumura I. Natural history as a predictor of protein evolvability. Protein Engineering, Design & Selection : Peds. 19: 439-42. PMID 16868005 DOI: 10.1093/Protein/Gzl029  0.408
2005 Patrick WM, Firth AE. Strategies and computational tools for improving randomized protein libraries. Biomolecular Engineering. 22: 105-12. PMID 16095966 DOI: 10.1016/J.Bioeng.2005.06.001  0.342
2005 Patrick WM, Blackburn JM. In vitro selection and characterization of a stable subdomain of phosphoribosylanthranilate isomerase. The Febs Journal. 272: 3684-97. PMID 16008567 DOI: 10.1111/J.1742-4658.2005.04794.X  0.564
2004 Gerth ML, Patrick WM, Lutz S. A second-generation system for unbiased reading frame selection. Protein Engineering, Design & Selection : Peds. 17: 595-602. PMID 15331775 DOI: 10.1093/Protein/Gzh068  0.325
2004 Lutz S, Patrick WM. Novel methods for directed evolution of enzymes: quality, not quantity. Current Opinion in Biotechnology. 15: 291-7. PMID 15296927 DOI: 10.1016/J.Copbio.2004.05.004  0.326
2003 Patrick WM, Firth AE, Blackburn JM. User-friendly algorithms for estimating completeness and diversity in randomized protein-encoding libraries. Protein Engineering. 16: 451-7. PMID 12874379 DOI: 10.1093/Protein/Gzg057  0.563
2002 Patrick WM, Weisner J, Blackburn JM. Site-directed mutagenesis of Tyr354 in Geobacillus stearothermophilus alanine racemase identifies a role in controlling substrate specificity and a possible role in the evolution of antibiotic resistance. Chembiochem : a European Journal of Chemical Biology. 3: 789-92. PMID 12203980 DOI: 10.1002/1439-7633(20020802)3:8<789::Aid-Cbic789>3.0.Co;2-D  0.573
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