Kelly L. Jordan-Sciutto, PhD - Publications

University of Pennsylvania, Philadelphia, PA, United States 
Molecular mechanisms underlying neuronal loss in neurodegenerative disorders

62 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Lopez Lloreda C, Chowdhury S, Ghura S, Alvarez-Periel E, Jordan-Sciutto K. HIV-Associated Insults Modulate ADAM10 and Its Regulator Sirtuin1 in an NMDA Receptor-Dependent Manner. Cells. 11. PMID 36230925 DOI: 10.3390/cells11192962  0.406
2022 Smith AS, Ankam S, Farhy C, Fiengo L, Basa RCB, Gordon KL, Martin CT, Terskikh AV, Jordan-Sciutto KL, Price JH, McDonough PM. High-content analysis and Kinetic Image Cytometry identify toxicity and epigenetic effects of HIV antiretrovirals on human iPSC-neurons and primary neural precursor cells. Journal of Pharmacological and Toxicological Methods. 107157. PMID 35143957 DOI: 10.1016/j.vascn.2022.107157  0.385
2021 Starr A, Jordan-Sciutto KL, Mironets E. Confound, Cause, or Cure: The Effect of Cannabinoids on HIV-Associated Neurological Sequelae. Viruses. 13. PMID 34206839 DOI: 10.3390/v13071242  0.35
2021 Roth LM, Akay-Espinoza C, Grinspan JB, Jordan-Sciutto KL. HIV-induced neuroinflammation inhibits oligodendrocyte maturation via glutamate-dependent activation of the PERK arm of the integrated stress response. Glia. PMID 34058792 DOI: 10.1002/glia.24033  0.399
2020 Roth LM, Zidane B, Festa L, Putatunda R, Romer M, Monnerie H, Jordan-Sciutto KL, Grinspan JB. Differential effects of integrase strand transfer inhibitors, elvitegravir and raltegravir, on oligodendrocyte maturation: A role for the integrated stress response. Glia. PMID 32894619 DOI: 10.1002/glia.23902  0.348
2020 Ryan SK, Gonzalez MV, Garifallou JP, Bennett FC, Williams KS, Sotuyo NP, Mironets E, Cook K, Hakonarson H, Anderson SA, Jordan-Sciutto KL. Neuroinflammation and EIF2 Signaling Persist despite Antiretroviral Treatment in an hiPSC Tri-culture Model of HIV Infection. Stem Cell Reports. PMID 32220329 DOI: 10.1016/J.Stemcr.2020.02.010  0.474
2020 Bond S, Lopez-Lloreda C, Gannon PJ, Akay-Espinoza C, Jordan-Sciutto KL. The Integrated Stress Response and Phosphorylated Eukaryotic Initiation Factor 2α in Neurodegeneration. Journal of Neuropathology and Experimental Neurology. PMID 31913484 DOI: 10.1093/Jnen/Nlz129  0.683
2019 Ghura S, Gross R, Jordan-Sciutto K, Dubroff J, Schnoll R, Collman RG, Ashare RL. Bidirectional Associations among Nicotine and Tobacco Smoke, NeuroHIV, and Antiretroviral Therapy. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 31834620 DOI: 10.1007/S11481-019-09897-4  0.318
2019 Festa L, Roth LM, K Jensen B, Geiger JD, Jordan-Sciutto KL, Grinspan JB. Protease Inhibitors, Saquinavir and Darunavir, Inhibit Oligodendrocyte Maturation: Implications for Lysosomal Stress. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 31776836 DOI: 10.1007/s11481-019-09893-8  0.396
2019 Jensen BK, Roth LM, Grinspan JB, Jordan-Sciutto KL. White matter loss and oligodendrocyte dysfunction in HIV: a consequence of the infection, the antiretroviral therapy or both? Brain Research. 146397. PMID 31442414 DOI: 10.1016/j.brainres.2019.146397  0.373
2018 Jackson DP, Ting JH, Pozniak PD, Meurice C, Schleidt SS, Dao A, Lee AH, Klinman E, Jordan-Sciutto KL. Identification and characterization of two novel alternatively spliced E2F1 transcripts in the rat CNS. Molecular and Cellular Neurosciences. PMID 29936143 DOI: 10.1016/J.Mcn.2018.06.003  0.716
2018 Stern AL, Ghura S, Gannon PJ, Akay-Espinoza C, Phan JM, Yee AC, Vassar R, Gelman BB, Kolson DL, Jordan-Sciutto KL. BACE1 mediates HIV-associated and excitotoxic neuronal damage through an APP-dependent mechanism. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29632166 DOI: 10.1523/Jneurosci.1280-17.2018  0.751
2017 Stern AL, Lee RN, Panvelker N, Li J, Harowitz J, Jordan-Sciutto KL, Akay-Espinoza C. Differential Effects of Antiretroviral Drugs on Neurons In Vitro: Roles for Oxidative Stress and Integrated Stress Response. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. PMID 28861811 DOI: 10.1007/s11481-017-9761-6  0.495
2017 Gannon PJ, Akay-Espinoza C, Yee AC, Briand LA, Erickson MA, Gelman BB, Gao Y, Haughey NJ, Zink MC, Clements JE, Kim NS, Van De Walle G, Jensen BK, Vassar R, Pierce RC, ... ... Jordan-Sciutto KL, et al. HIV Protease Inhibitors Alter Amyloid Precursor Protein Processing via β-Site Amyloid Precursor Protein Cleaving Enzyme-1 Translational Up-Regulation. The American Journal of Pathology. 187: 91-109. PMID 27993242 DOI: 10.1016/J.Ajpath.2016.09.006  0.751
2016 Monnerie H, Romer M, Jensen BK, Millar JS, Jordan-Sciutto KL, Kim SF, Grinspan JB. Reduced Sterol Regulatory Element-Binding Protein (SREBP) Processing Through Site-1 Protease (S1P) inhibition Alters Oligodendrocyte Differentiation in vitro. Journal of Neurochemistry. PMID 27385127 DOI: 10.1111/jnc.13721  0.318
2015 Colacurcio DJ, Zyskind JW, Jordan-Sciutto KL, Espinoza CA. Caspase-dependent degradation of MDMx/MDM4 cell cycle regulatory protein in amyloid β-induced neuronal damage. Neuroscience Letters. 609: 182-188. PMID 26477779 DOI: 10.1016/j.neulet.2015.10.031  0.514
2015 Jensen BK, Monnerie H, Mannell MV, Gannon PJ, Espinoza CA, Erickson MA, Bruce-Keller AJ, Gelman BB, Briand LA, Pierce RC, Jordan-Sciutto KL, Grinspan JB. Altered Oligodendrocyte Maturation and Myelin Maintenance: The Role of Antiretrovirals in HIV-Associated Neurocognitive Disorders. Journal of Neuropathology and Experimental Neurology. 74: 1093-118. PMID 26469251 DOI: 10.1097/Nen.0000000000000255  0.691
2015 Zyskind JW, Wang Y, Cho G, Ting JH, Kolson DL, Lynch DR, Jordan-Sciutto KL. E2F1 in neurons is cleaved by calpain in an NMDA receptor-dependent manner in a model of HIV-induced neurotoxicity. Journal of Neurochemistry. 132: 742-55. PMID 25279448 DOI: 10.1111/Jnc.12956  0.773
2014 Gill AJ, Kovacsics CE, Cross SA, Vance PJ, Kolson LL, Jordan-Sciutto KL, Gelman BB, Kolson DL. Heme oxygenase-1 deficiency accompanies neuropathogenesis of HIV-associated neurocognitive disorders. The Journal of Clinical Investigation. 124: 4459-72. PMID 25202977 DOI: 10.1172/Jci72279  0.488
2014 Ting JH, Marks DR, Schleidt SS, Wu JN, Zyskind JW, Lindl KA, Blendy JA, Pierce RC, Jordan-Sciutto KL. Targeted gene mutation of E2F1 evokes age-dependent synaptic disruption and behavioral deficits. Journal of Neurochemistry. 129: 850-63. PMID 24460902 DOI: 10.1111/Jnc.12655  0.768
2014 Akay C, Cooper M, Odeleye A, Jensen BK, White MG, Vassoler F, Gannon PJ, Mankowski J, Dorsey JL, Buch AM, Cross SA, Cook DR, Peña MM, Andersen ES, Christofidou-Solomidou M, ... ... Jordan-Sciutto KL, et al. Antiretroviral drugs induce oxidative stress and neuronal damage in the central nervous system. Journal of Neurovirology. 20: 39-53. PMID 24420448 DOI: 10.1007/S13365-013-0227-1  0.803
2013 Colacurcio DJ, Yeager A, Kolson DL, Jordan-Sciutto KL, Akay C. Calpain-mediated degradation of MDMx/MDM4 contributes to HIV-induced neuronal damage. Molecular and Cellular Neurosciences. 57: 54-62. PMID 24128662 DOI: 10.1016/J.Mcn.2013.10.003  0.568
2012 Wang Y, Zyskind JW, Colacurcio DJ, Lindl KA, Ting JH, Grigoriev G, Jordan-Sciutto KL. Differential roles for caspase-mediated and calpain-mediated cell death in 1- and 3-week-old rat cortical cultures. Neuroreport. 23: 1052-8. PMID 23111339 DOI: 10.1097/Wnr.0B013E32835Ad25D  0.756
2012 Akay C, Lindl KA, Shyam N, Nabet B, Goenaga-Vazquez Y, Ruzbarsky J, Wang Y, Kolson DL, Jordan-Sciutto KL. Activation status of integrated stress response pathways in neurones and astrocytes of HIV-associated neurocognitive disorders (HAND) cortex. Neuropathology and Applied Neurobiology. 38: 175-200. PMID 21883374 DOI: 10.1111/J.1365-2990.2011.01215.X  0.825
2011 Cross SA, Cook DR, Chi AW, Vance PJ, Kolson LL, Wong BJ, Jordan-Sciutto KL, Kolson DL. Dimethyl fumarate, an immune modulator and inducer of the antioxidant response, suppresses HIV replication and macrophage-mediated neurotoxicity: a novel candidate for HIV neuroprotection. Journal of Immunology (Baltimore, Md. : 1950). 187: 5015-25. PMID 21976775 DOI: 10.4049/Jimmunol.1101868  0.475
2011 Dong L, Guarino BB, Jordan-Sciutto KL, Winkelstein BA. Activating transcription factor 4, a mediator of the integrated stress response, is increased in the dorsal root ganglia following painful facet joint distraction. Neuroscience. 193: 377-86. PMID 21821103 DOI: 10.1016/J.Neuroscience.2011.07.059  0.31
2011 Cook DR, Gleichman AJ, Cross SA, Doshi S, Ho W, Jordan-Sciutto KL, Lynch DR, Kolson DL. NMDA receptor modulation by the neuropeptide apelin: implications for excitotoxic injury. Journal of Neurochemistry. 118: 1113-23. PMID 21749375 DOI: 10.1111/J.1471-4159.2011.07383.X  0.368
2011 Akay C, Lindl KA, Wang Y, White MG, Isaacman-Beck J, Kolson DL, Jordan-Sciutto KL. Site-specific hyperphosphorylation of pRb in HIV-induced neurotoxicity. Molecular and Cellular Neurosciences. 47: 154-65. PMID 21504794 DOI: 10.1016/J.Mcn.2011.04.001  0.821
2011 White MG, Wang Y, Akay C, Lindl KA, Kolson DL, Jordan-Sciutto KL. Parallel high throughput neuronal toxicity assays demonstrate uncoupling between loss of mitochondrial membrane potential and neuronal damage in a model of HIV-induced neurodegeneration. Neuroscience Research. 70: 220-9. PMID 21291924 DOI: 10.1016/J.Neures.2011.01.013  0.819
2010 Wang Y, Shyam N, Ting JH, Akay C, Lindl KA, Jordan-Sciutto KL. E2F1 localizes predominantly to neuronal cytoplasm and fails to induce expression of its transcriptional targets in human immunodeficiency virus-induced neuronal damage. Neuroscience Letters. 479: 97-101. PMID 20580656 DOI: 10.1016/J.Neulet.2010.05.032  0.82
2010 Lindl KA, Marks DR, Kolson DL, Jordan-Sciutto KL. HIV-associated neurocognitive disorder: pathogenesis and therapeutic opportunities. Journal of Neuroimmune Pharmacology : the Official Journal of the Society On Neuroimmune Pharmacology. 5: 294-309. PMID 20396973 DOI: 10.1007/S11481-010-9205-Z  0.811
2008 Lindl KA, Jordan-Sciutto KL. Examining the endogenous antioxidant response through immunofluorescent analysis of Nrf2 in tissue. Methods in Molecular Biology (Clifton, N.J.). 477: 229-43. PMID 19082951 DOI: 10.1007/978-1-60327-517-0_18  0.773
2007 Markowitz AJ, White MG, Kolson DL, Jordan-Sciutto KL. Cellular interplay between neurons and glia: toward a comprehensive mechanism for excitotoxic neuronal loss in neurodegeneration. Cellscience. 4: 111-146. PMID 19122795  0.526
2007 Lindl KA, Akay C, Wang Y, White MG, Jordan-Sciutto KL. Expression of the endoplasmic reticulum stress response marker, BiP, in the central nervous system of HIV-positive individuals. Neuropathology and Applied Neurobiology. 33: 658-69. PMID 17931354 DOI: 10.1111/J.1365-2990.2007.00866.X  0.82
2007 Chu CT, Plowey ED, Wang Y, Patel V, Jordan-Sciutto KL. Location, location, location: altered transcription factor trafficking in neurodegeneration. Journal of Neuropathology and Experimental Neurology. 66: 873-83. PMID 17917581 DOI: 10.1097/Nen.0B013E318156A3D7  0.725
2007 Wang Y, White MG, Akay C, Chodroff RA, Robinson J, Lindl KA, Dichter MA, Qian Y, Mao Z, Kolson DL, Jordan-Sciutto KL. Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity. Journal of Neurochemistry. 103: 439-55. PMID 17897354 DOI: 10.1111/J.1471-4159.2007.04746.X  0.818
2007 Ramsey CP, Glass CA, Montgomery MB, Lindl KA, Ritson GP, Chia LA, Hamilton RL, Chu CT, Jordan-Sciutto KL. Expression of Nrf2 in neurodegenerative diseases. Journal of Neuropathology and Experimental Neurology. 66: 75-85. PMID 17204939 DOI: 10.1097/Nen.0B013E31802D6Da9  0.786
2006 Wang Y, Xie WY, He Y, Wang M, Yang YR, Zhang Y, Yin DM, Jordan-Sciutto KL, Han JS, Wang Y. Role of CDK5 in neuroprotection from serum deprivation by mu-opioid receptor agonist. Experimental Neurology. 202: 313-23. PMID 16879821 DOI: 10.1016/J.Expneurol.2006.06.005  0.327
2006 O'Donnell LA, Agrawal A, Jordan-Sciutto KL, Dichter MA, Lynch DR, Kolson DL. Human immunodeficiency virus (HIV)-induced neurotoxicity: roles for the NMDA receptor subtypes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 981-90. PMID 16421318 DOI: 10.1523/Jneurosci.4617-05.2006  0.539
2005 Chalovich EM, Koike MA, Aras MA, Murphey-Corb M, Wiley CA, Jordan-Sciutto KL. Pocket proteins p107 and p130 exhibit increased expression in macrophages during SIV encephalitis. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 25: 315-25. PMID 16382780 DOI: 10.1111/J.1440-1789.2005.00645.X  0.573
2005 Strachan GD, Ostrow LA, Jordan-Sciutto KL. Expression of the fetal Alz-50 clone 1 protein induces apoptotic cell death. Biochemical and Biophysical Research Communications. 336: 490-5. PMID 16137655 DOI: 10.1016/j.bbrc.2005.08.127  0.4
2005 Strachan GD, Koike MA, Siman R, Hall DJ, Jordan-Sciutto KL. E2F1 induces cell death, calpain activation, and MDMX degradation in a transcription independent manner implicating a novel role for E2F1 in neuronal loss in SIV encephalitis. Journal of Cellular Biochemistry. 96: 728-40. PMID 16088944 DOI: 10.1002/jcb.20574  0.567
2005 Morgan KL, Chalovich EM, Strachan GD, Otis LL, Jordan-Sciutto KL. E2F4 expression patterns in SIV encephalitis. Neuroscience Letters. 382: 259-64. PMID 15925101 DOI: 10.1016/J.Neulet.2005.03.044  0.427
2005 Strachan GD, Kopp AS, Koike MA, Morgan KL, Jordan-Sciutto KL. Chemokine- and neurotrophic factor-induced changes in E2F1 localization and phosphorylation of the retinoblastoma susceptibility gene product (pRb) occur by distinct mechanisms in murine cortical cultures. Experimental Neurology. 193: 455-68. PMID 15869948 DOI: 10.1016/j.expneurol.2004.08.038  0.432
2004 Strachan GD, Morgan KL, Otis LL, Caltagarone J, Gittis A, Bowser R, Jordan-Sciutto KL. Fetal Alz-50 clone 1 interacts with the human orthologue of the Kelch-like Ech-associated protein. Biochemistry. 43: 12113-22. PMID 15379550 DOI: 10.1021/Bi0494166  0.621
2004 Jordan-Sciutto KL, Glass CA, Kopp AS, Morgan KL, Koike MA. P4-236 Expression of the antioxidant response transcriptional regulator, NRF2, in Alzheimer's disease Neurobiology of Aging. 25: S542-S543. DOI: 10.1016/S0197-4580(04)81794-9  0.328
2003 Rhodes J, Lutka FA, Jordan-Sciutto KL, Bowser R. Altered expression and distribution of FAC1 during NGF-induced neurite outgrowth of PC12 cells. Neuroreport. 14: 449-52. PMID 12634501 DOI: 10.1097/00001756-200303030-00030  0.591
2003 Strachan GD, Jordan-Sciutto KL, Rallapalli R, Tuan RS, Hall DJ. The E2F-1 transcription factor is negatively regulated by its interaction with the MDMX protein. Journal of Cellular Biochemistry. 88: 557-68. PMID 12532331 DOI: 10.1002/Jcb.10318  0.429
2003 Jordan-Sciutto KL, Dorsey R, Chalovich EM, Hammond RR, Achim CL. Expression patterns of retinoblastoma protein in Parkinson disease. Journal of Neuropathology and Experimental Neurology. 62: 68-74. PMID 12528819 DOI: 10.1093/Jnen/62.1.68  0.66
2002 Jordan-Sciutto KL, Malaiyandi LM, Bowser R. Altered distribution of cell cycle transcriptional regulators during Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 61: 358-67. PMID 11939591 DOI: 10.1093/Jnen/61.4.358  0.588
2002 Jordan-Sciutto KL, Wang G, Murphey-Corb M, Wiley CA. Cell cycle proteins exhibit altered expression patterns in lentiviral-associated encephalitis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 2185-95. PMID 11896158 DOI: 10.1523/Jneurosci.22-06-02185.2002  0.599
2001 Jordan-Sciutto K, Rhodes J, Bowser R. Altered subcellular distribution of transcriptional regulators in response to Aβ peptide and during Alzheimer's disease Mechanisms of Ageing and Development. 123: 11-20. PMID 11640947 DOI: 10.1016/S0047-6374(01)00334-7  0.576
2001 Jordan-Sciutto KL, Murray Fenner BA, Wiley CA, Achim CL. Response of cell cycle proteins to neurotrophic factor and chemokine stimulation in human neuroglia. Experimental Neurology. 167: 205-14. PMID 11161609 DOI: 10.1006/Exnr.2000.7594  0.716
2000 Jordan-Sciutto KL, Wang G, Murphy-Corb M, Wiley CA. Induction of cell-cycle regulators in simian immunodeficiency virus encephalitis. The American Journal of Pathology. 157: 497-507. PMID 10934153 DOI: 10.1016/S0002-9440(10)64561-0  0.594
2000 Jordan-Sciutto KL, Dragich JM, Caltagarone J, Hall DJ, Bowser R. Fetal Alz-50 clone 1 (FAC1) protein interacts with the Myc-associated zinc finger protein (ZF87/MAZ) and alters its transcriptional activity. Biochemistry. 39: 3206-15. PMID 10727212 DOI: 10.1021/Bi992211Q  0.626
2000 Bowser RP, Jordan-Sciutto KL, Rhodes JL. Functional role of transcription factors during aβinduced neuronal cell death Neurobiology of Aging. 21: 53. DOI: 10.1016/S0197-4580(00)82916-4  0.641
1999 Jordan-Sciutto KL, Morgan K, Bowser R. Increased Cyclin G1 Immunoreactivity During Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. 1: 409-417. PMID 12214116 DOI: 10.3233/Jad-1999-1605  0.585
1999 Jordan-Sciutto KL, Dragich JM, Rhodes JL, Bowser R. Fetal Alz-50 clone 1, a novel zinc finger protein, binds a specific DNA sequence and acts as a transcriptional regulator. The Journal of Biological Chemistry. 274: 35262-8. PMID 10575013 DOI: 10.1074/Jbc.274.49.35262  0.514
1999 Jordan-Sciutto KL, Dragich JM, Bowser R. DNA binding activity of the fetal Alz-50 clone 1 (FAC1) protein is enhanced by phosphorylation. Biochemical and Biophysical Research Communications. 260: 785-9. PMID 10403843 DOI: 10.1006/Bbrc.1999.0986  0.559
1998 Jordan-Sciutto KL, Hall DJ. A mutant E2F-1 transcription factor that affects the phenotype of NIH3T3 fibroblasts inefficiency associates with cyclin A-cdk2. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire. 76: 37-44. PMID 9666304 DOI: 10.1139/O98-015  0.421
1998 Jordan-Sciutto K, Bowser R. Alzheimer's disease and brain development: common molecular pathways Frontiers in Bioscience : a Journal and Virtual Library. 3: d100-112. PMID 9422711  0.548
1997 Jordan-Sciutto KL, Logan TJ, Norton PA, Derfoul A, Dodge GR, Hall DJ. Reduction in fibronectin expression and alteration in cell morphology are coincident in NIH3T3 cells expressing a mutant E2F1 transcription factor. Experimental Cell Research. 236: 527-36. PMID 9367638 DOI: 10.1006/excr.1997.3762  0.42
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