Junjie Chen, Ph.D. - Publications

2009- Department of Experimental Radiation Oncology The University of Texas M. D. Anderson Cancer Center, USA 
genomic stability, DNA damage responsive pathways, cancer biology

247 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Nie L, Wang C, Huang M, Liu X, Feng X, Tang M, Li S, Hang Q, Teng H, Shen X, Ma L, Gan B, Chen J. DePARylation is critical for S phase progression and cell survival. Elife. 12. PMID 38578205 DOI: 10.7554/eLife.89303  0.358
2024 Zhao M, Wang T, Gleber-Netto FO, Chen Z, McGrail DJ, Gomez JA, Ju W, Gadhikar MA, Ma W, Shen L, Wang Q, Tang X, Pathak S, Raso MG, Burks JK, ... ... Chen J, et al. Mutant p53 gains oncogenic functions through a chromosomal instability-induced cytosolic DNA response. Nature Communications. 15: 180. PMID 38167338 DOI: 10.1038/s41467-023-44239-2  0.325
2023 Zhang H, Xiong Y, Sun Y, Park JM, Su D, Feng X, Keast S, Tang M, Huang M, Wang C, Srivastava M, Yang C, Zhu D, Chen Z, Li S, ... ... Chen J, et al. RAD54L2-mediated DNA damage avoidance pathway specifically preserves genome integrity in response to topoisomerase 2 poisons. Science Advances. 9: eadi6681. PMID 38055811 DOI: 10.1126/sciadv.adi6681  0.4
2023 Nie L, Wang C, Liu X, Huang M, Feng X, Tang M, Li S, Hang Q, Teng H, Shen X, Ma L, Gan B, Chen J. DePARylation is critical for S phase progression and cell survival. Biorxiv : the Preprint Server For Biology. PMID 37577639 DOI: 10.1101/2023.07.31.551317  0.358
2023 Huang M, Yao F, Nie L, Wang C, Su D, Zhang H, Li S, Tang M, Feng X, Yu B, Chen Z, Wang S, Yin L, Mou L, Hart T, ... Chen J, et al. FACS-based genome-wide CRISPR screens define key regulators of DNA damage signaling pathways. Molecular Cell. 83: 2810-2828.e6. PMID 37541219 DOI: 10.1016/j.molcel.2023.07.004  0.351
2023 Chen J, Chapski DJ, Jong J, Awada J, Wang Y, Slamon DJ, Vondriska TM, Packard RRS. Integrative transcriptomics and cell systems analyses reveal protective pathways controlled by Igfbp-3 in anthracycline-induced cardiotoxicity. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 37: e22977. PMID 37219486 DOI: 10.1096/fj.202201885RR  0.301
2023 Park JM, Zhang H, Nie L, Wang C, Huang M, Feng X, Tang M, Chen Z, Xiong Y, Lee N, Li S, Yin L, Hart T, Chen J. Genome-Wide CRISPR Screens Reveal ZATT as a Synthetic Lethal Target of TOP2-Poison Etoposide That Can Act in a TDP2-Independent Pathway. International Journal of Molecular Sciences. 24. PMID 37047518 DOI: 10.3390/ijms24076545  0.369
2022 Zhang H, Xiong Y, Su D, Wang C, Srivastava M, Tang M, Feng X, Huang M, Chen Z, Chen J. TDP1-independent pathways in the process and repair of TOP1-induced DNA damage. Nature Communications. 13: 4240. PMID 35869071 DOI: 10.1038/s41467-022-31801-7  0.379
2022 Tang M, Chen Z, Wang C, Feng X, Lee N, Huang M, Zhang H, Li S, Xiong Y, Chen J. Histone chaperone ASF1 acts with RIF1 to promote DNA end-joining in BRCA1-deficient cells. The Journal of Biological Chemistry. 101979. PMID 35472331 DOI: 10.1016/j.jbc.2022.101979  0.439
2021 Wang C, Tang M, Chen Z, Nie L, Li S, Xiong Y, Szymonowicz KA, Park JM, Zhang H, Feng X, Huang M, Su D, Hart T, Chen J. Genetic vulnerabilities upon inhibition of DNA damage response. Nucleic Acids Research. PMID 34320214 DOI: 10.1093/nar/gkab643  0.3
2021 Hang Q, Zeng L, Wang L, Nie L, Yao F, Teng H, Deng Y, Yap S, Sun Y, Frank SJ, Chen J, Ma L. Non-canonical function of DGCR8 in DNA double-strand break repair signaling and tumor radioresistance. Nature Communications. 12: 4033. PMID 34188037 DOI: 10.1038/s41467-021-24298-z  0.379
2021 Tang M, Li S, Chen J. Ubiquitylation in DNA double-strand break repair. Dna Repair. 103: 103129. PMID 33990032 DOI: 10.1016/j.dnarep.2021.103129  0.379
2021 Chen Z, Chen J. Mass spectrometry-based protein‒protein interaction techniques and their applications in studies of DNA damage repair. Journal of Zhejiang University. Science. B. 22: 1-20. PMID 33448183 DOI: 10.1631/jzus.B2000356  0.325
2020 Chen Z, Wang C, Jain A, Srivastava M, Tang M, Zhang H, Feng X, Nie L, Su D, Xiong Y, Jung SY, Qin J, Chen J. AMPK Interactome Reveals New Function in Non-homologous End Joining DNA Repair. Molecular & Cellular Proteomics : McP. 19: 467-477. PMID 33451682 DOI: 10.1074/mcp.RA119.001794  0.318
2020 Wang R, Lenoir WF, Wang C, Su D, McLaughlin M, Hu Q, Shen X, Tian Y, Klages-Mundt N, Lynn E, Wood RD, Chen J, Hart T, Li L. DNA polymerase ι compensates for Fanconi anemia pathway deficiency by countering DNA replication stress. Proceedings of the National Academy of Sciences of the United States of America. 117: 33436-33445. PMID 33376220 DOI: 10.1073/pnas.2008821117  0.392
2020 Shen X, Wang R, Kim MJ, Hu Q, Hsu CC, Yao J, Klages-Mundt N, Tian Y, Lynn E, Brewer TF, Zhang Y, Arun B, Gan B, Andreeff M, Takeda S, ... Chen J, et al. A Surge of DNA Damage Links Transcriptional Reprogramming and Hematopoietic Deficit in Fanconi Anemia. Molecular Cell. 80: 1013-1024.e6. PMID 33338401 DOI: 10.1016/j.molcel.2020.11.040  0.37
2020 Nie L, Wang C, Li N, Feng X, Lee N, Su D, Tang M, Yao F, Chen J. Proteome-wide analysis reveals substrates of E3 ligase RNF146 targeted for degradation. Molecular & Cellular Proteomics : McP. PMID 32958691 DOI: 10.1074/Mcp.Ra120.002290  0.315
2020 Wang C, Chen Z, Su D, Tang M, Nie L, Zhang H, Feng X, Wang R, Shen X, Srivastava M, McLaughlin ME, Hart T, Li L, Chen J. C17orf53 is identified as a novel gene involved in inter-strand crosslink repair. Dna Repair. 95: 102946. PMID 32853826 DOI: 10.1016/J.Dnarep.2020.102946  0.499
2020 Tang M, Feng X, Pei G, Srivastava M, Wang C, Chen Z, Li S, Zhang H, Zhao Z, Li X, Chen J. FOXK1 Participates in DNA Damage Response by Controlling 53BP1 Function. Cell Reports. 32: 108018. PMID 32783940 DOI: 10.1016/J.Celrep.2020.108018  0.512
2020 Feng X, Tubbs A, Zhang C, Tang M, Sridharan S, Wang C, Jiang D, Su D, Zhang H, Chen Z, Nie L, Xiong Y, Huang M, Nussenzweig A, Chen J. ATR inhibition potentiates ionizing radiation-induced interferon response via cytosolic nucleic acid-sensing pathways. The Embo Journal. e104036. PMID 32484965 DOI: 10.15252/Embj.2019104036  0.433
2020 Chen Z, Wang C, Lei C, Feng X, Li C, Jung SY, Qin J, Chen J. Phosphoproteomics Analysis Reveals a Potential Role of CHK1 in Regulation of Innate Immunity through IRF3. Journal of Proteome Research. PMID 32314919 DOI: 10.1021/Acs.Jproteome.9B00829  0.45
2020 Srivastava M, Su D, Zhang H, Chen Z, Tang M, Nie L, Chen J. HMCES safeguards replication from oxidative stress and ensures error-free repair. Embo Reports. e49123. PMID 32307824 DOI: 10.15252/Embr.201949123  0.412
2020 Huang M, Feng X, Su D, Wang G, Wang C, Tang M, Paulucci-Holthauzen A, Hart T, Chen J. Genome-wide CRISPR screen uncovers a synergistic effect of combining Haspin and Aurora kinase B inhibition. Oncogene. PMID 32300176 DOI: 10.1038/S41388-020-1296-2  0.314
2020 Hu Q, Klages-Mundt N, Wang R, Lynn E, Kuma Saha L, Zhang H, Srivastava M, Shen X, Tian Y, Kim H, Ye Y, Paull T, Takeda S, Chen J, Li L. The ARK Assay Is a Sensitive and Versatile Method for the Global Detection of DNA-Protein Crosslinks. Cell Reports. 30: 1235-1245.e4. PMID 31995761 DOI: 10.1016/J.Celrep.2019.12.067  0.35
2020 Su D, Feng X, Colic M, Wang Y, Zhang C, Wang C, Tang M, Hart T, Chen J. CRISPR/CAS9-based DNA damage response screens reveal gene-drug interactions. Dna Repair. 87: 102803. PMID 31991288 DOI: 10.1016/J.Dnarep.2020.102803  0.365
2020 Zhang H, Xiong Y, Chen J. DNA-protein cross-link repair: what do we know now? Cell & Bioscience. 10: 3. PMID 31921408 DOI: 10.1186/s13578-019-0366-z  0.394
2020 Chen Z, Wang C, Jain A, Srivastava M, Tang M, Zhang H, Feng X, Nie L, Su D, Xiong Y, Jung SY, Qin J, Chen J. AMPK interactome reveals its new function in non-homologous end joining DNA repair. Molecular & Cellular Proteomics : McP. PMID 31900314 DOI: 10.1074/mcp.RA119.001794  0.318
2019 Vargas RE, Duong VT, Han H, Ta AP, Chen Y, Zhao S, Yang B, Seo G, Chuc K, Oh S, El Ali A, Razorenova OV, Chen J, Luo R, Li X, et al. Elucidation of WW domain ligand binding specificities in the Hippo pathway reveals STXBP4 as YAP inhibitor. The Embo Journal. e102406. PMID 31782549 DOI: 10.15252/Embj.2019102406  0.387
2019 Xu M, Qin J, Wang L, Lee HJ, Kao CY, Liu D, Songyang Z, Chen J, Tsai MJ, Tsai SY. Nuclear receptors regulate alternative lengthening of telomeres through a novel noncanonical FANCD2 pathway. Science Advances. 5: eaax6366. PMID 31633027 DOI: 10.1126/Sciadv.Aax6366  0.468
2019 Zhang H, Chen Z, Ye Y, Ye Z, Cao D, Xiong Y, Srivastava M, Feng X, Tang M, Wang C, Tainer JA, Chen J. SLX4IP acts with SLX4 and XPF-ERCC1 to promote interstrand crosslink repair. Nucleic Acids Research. PMID 31495888 DOI: 10.1093/nar/gkz769  0.4
2019 Huang J, Zhang J, Bellani MA, Pokharel D, Gichimu J, James RC, Gali H, Ling C, Yan Z, Xu D, Chen J, Meetei AR, Li L, Wang W, Seidman MM. Remodeling of Interstrand Crosslink Proximal Replisomes Is Dependent on ATR, FANCM, and FANCD2. Cell Reports. 27: 1794-1808.e5. PMID 31067464 DOI: 10.1016/J.Celrep.2019.04.032  0.443
2019 Zhao M, Wang T, Zhen C, Wang J, Pickering CR, Chen J, Myers JN, Zhou G. Abstract 5289: Gain-of-function mutant p53 predisposes head and neck keratinocytes and squamous cell carcinoma cells to replicative stress and genomic instability through minichromosome maintenance complex component 5 Cancer Research. 79: 5289-5289. DOI: 10.1158/1538-7445.Am2019-5289  0.387
2018 Srivastava M, Chen Z, Zhang H, Tang M, Wang C, Jung SY, Chen J. Replisome Dynamics and Their Functional Relevance upon DNA Damage through the PCNA Interactome. Cell Reports. 25: 3869-3883.e4. PMID 30590055 DOI: 10.1016/j.celrep.2018.11.099  0.367
2018 Wang C, Wang G, Feng X, Shepherd P, Zhang J, Tang M, Chen Z, Srivastava M, McLaughlin ME, Navone NM, Hart GT, Chen J. Genome-wide CRISPR screens reveal synthetic lethality of RNASEH2 deficiency and ATR inhibition. Oncogene. PMID 30532030 DOI: 10.1038/S41388-018-0606-4  0.434
2018 Jung YS, Jun S, Kim MJ, Lee SH, Suh HN, Lien EM, Jung HY, Lee S, Zhang J, Yang JI, Ji H, Wu JY, Wang W, Miller RK, Chen J, et al. TMEM9 promotes intestinal tumorigenesis through vacuolar-ATPase-activated Wnt/β-catenin signalling. Nature Cell Biology. PMID 30374053 DOI: 10.1038/S41556-018-0219-8  0.315
2018 Jung YS, Wang W, Jun S, Zhang J, Srivastava M, Kim MJ, Lien EM, Shang J, Chen J, McCrea PD, Zhang S, Park JI. Deregulation of CRAD-controlled cytoskeleton initiates mucinous colorectal cancer via β-catenin. Nature Cell Biology. 20: 1303-1314. PMID 30361697 DOI: 10.1038/S41556-018-0215-Z  0.336
2018 Xu R, Xu Y, Huo W, Lv Z, Yuan J, Ning S, Wang Q, Hou M, Gao G, Ji J, Chen J, Guo R, Xu D. Mitosis-specific MRN complex promotes a mitotic signaling cascade to regulate spindle dynamics and chromosome segregation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30297404 DOI: 10.1073/Pnas.1806665115  0.396
2018 Zhang P, Xiao Z, Wang S, Zhang M, Wei Y, Hang Q, Kim J, Yao F, Rodriguez-Aguayo C, Ton BN, Lee M, Wang Y, Zhou Z, Zeng L, Hu X, ... ... Chen J, et al. ZRANB1 Is an EZH2 Deubiquitinase and a Potential Therapeutic Target in Breast Cancer. Cell Reports. 23: 823-837. PMID 29669287 DOI: 10.1016/J.Celrep.2018.03.078  0.316
2018 Huang Y, Hu K, Zhang S, Dong X, Yin Z, Meng R, Zhao Y, Dai X, Zhang T, Yang K, Liu L, Huang K, Shi S, Zhang Y, Chen J, et al. S6K1 phosphorylation-dependent degradation of Mxi1 by β-Trcp ubiquitin ligase promotes Myc activation and radioresistance in lung cancer. Theranostics. 8: 1286-1300. PMID 29507620 DOI: 10.7150/Thno.22552  0.335
2018 Xie J, Li Y, Jiang K, Hu K, Zhang S, Dong X, Dai X, Liu L, Zhang T, Yang K, Huang K, Chen J, Shi S, Zhang Y, Wu G, et al. CDK16 Phosphorylates and Degrades p53 to Promote Radioresistance and Predicts Prognosis in Lung Cancer. Theranostics. 8: 650-662. PMID 29344296 DOI: 10.7150/Thno.21963  0.367
2018 Jung Y, Wang W, Jun S, Zhang J, Srivastava M, Kim MJ, Lien EM, Shang J, McCrea PD, Zhang S, Chen J, Park J. Abstract 4473: Tumorigenesis by deregulation of CRAD-controlled cytoskeleton dynamics Cancer Research. 78: 4473-4473. DOI: 10.1158/1538-7445.Am2018-4473  0.353
2017 Tian Y, Shen X, Wang R, Klages-Mundt N, Lynn EJ, Martin SK, Ye Y, Gao M, Chen J, Schlacher K, Li L. Constitutive role of the Fanconi anemia D2 gene in the replication stress response. The Journal of Biological Chemistry. PMID 29021208 DOI: 10.1074/Jbc.M117.814780  0.458
2017 Li X, Han H, Zhou MT, Yang B, Ta AP, Li N, Chen J, Wang W. Proteomic Analysis of the Human Tankyrase Protein Interaction Network Reveals Its Role in Pexophagy. Cell Reports. 20: 737-749. PMID 28723574 DOI: 10.1016/J.Celrep.2017.06.077  0.334
2017 Zhang A, Peng B, Huang P, Chen J, Gong Z. The p53-binding Protein 1-Tudor Interacting Repair Regulator Complex Participates in the DNA Damage Response. The Journal of Biological Chemistry. PMID 28213517 DOI: 10.1074/Jbc.M117.777474  0.493
2017 Li X, Gao M, Choi JM, Kim BJ, Zhou MT, Chen Z, Jain AN, Jung SY, Yuan J, Wang W, Wang Y, Chen J. CRISPR/Cas9-Coupled Affinity Purification/Mass Spectrometry Analysis Revealed a Novel Role of Neurofibromin in mTOR Signaling. Molecular & Cellular Proteomics : McP. PMID 28174230 DOI: 10.1074/Mcp.M116.064543  0.361
2017 Chen J, Shukla V, Farci P, Andricovich J, Jogunoori W, Kwong LN, Katz LH, Shetty K, Rashid A, Su X, White J, Li L, Wang AY, Blechacz B, Raju GS, ... ... Chen J, et al. Loss of the transforming growth factor-β effector β2-Spectrin promotes genomic instability. Hepatology (Baltimore, Md.). 65: 678-693. PMID 28114741 DOI: 10.1002/Hep.28927  0.328
2016 Chen J, Shukla V, Farci P, Andricovich J, Jogunoori W, Kwong LN, Katz LH, Shetty K, Rashid A, Su X, White J, Li L, Wang AY, Blechacz B, Raju GS, ... ... Chen J, et al. Loss of the TGF-β Effector β2SP Promotes Genomic Instability. Hepatology (Baltimore, Md.). PMID 27831662 DOI: 10.1002/hep.28927  0.338
2016 Lee YC, Zhou Q, Chen J, Yuan J. RPA-Binding Protein ETAA1 Is an ATR Activator Involved in DNA Replication Stress Response. Current Biology : Cb. PMID 27818175 DOI: 10.1016/j.cub.2016.10.030  0.348
2016 Li X, Tran KM, Aziz KE, Sorokin AV, Chen J, Wang W. Defining the protein-protein interaction network of the human protein tyrosine phosphatase family. Molecular & Cellular Proteomics : McP. PMID 27432908 DOI: 10.1074/Mcp.M116.060277  0.368
2016 Wang L, Zhang P, Molkentine DP, Chen C, Molkentine JM, Piao H, Raju U, Zhang J, Valdecanas DR, Tailor RC, Thames HD, Buchholz TA, Chen J, Ma L, Mason KA, et al. TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects. Oncogene. PMID 27425591 DOI: 10.1038/Onc.2016.250  0.317
2016 Li X, Wang W, Xi Y, Gao M, Tran M, Aziz KE, Qin J, Li W, Chen J. FOXR2 Interacts with MYC to Promote Its Transcriptional Activities and Tumorigenesis. Cell Reports. PMID 27346356 DOI: 10.1016/J.Celrep.2016.06.004  0.349
2016 Li N, Feng L, Liu H, Wang J, Kasembeli M, Tran MK, Tweardy DJ, Lin SH, Chen J. PARP Inhibition Suppresses Growth of EGFR-Mutant Cancers by Targeting Nuclear PKM2. Cell Reports. PMID 27149849 DOI: 10.1016/J.Celrep.2016.03.070  0.312
2016 Chen Z, Tran M, Tang M, Wang W, Gong Z, Chen J. Proteomic Analysis Reveals a Novel Mutator S (MutS) Partner Involved in Mismatch Repair Pathway. Molecular & Cellular Proteomics : McP. 15: 1299-308. PMID 27037360 DOI: 10.1074/Mcp.M115.056093  0.451
2016 Jun S, Jung YS, Suh HN, Wang W, Kim MJ, Oh YS, Lien EM, Shen X, Matsumoto Y, McCrea PD, Li L, Chen J, Park JI. LIG4 mediates Wnt signalling-induced radioresistance. Nature Communications. 7: 10994. PMID 27009971 DOI: 10.1038/Ncomms10994  0.393
2016 Liu X, Xiao ZD, Han L, Zhang J, Lee SW, Wang W, Lee H, Zhuang L, Chen J, Lin HK, Wang J, Liang H, Gan B. LncRNA NBR2 engages a metabolic checkpoint by regulating AMPK under energy stress. Nature Cell Biology. PMID 26999735 DOI: 10.1038/Ncb3328  0.306
2016 Zhang W, Wu KP, Sartori MA, Kamadurai HB, Ordureau A, Jiang C, Mercredi PY, Murchie R, Hu J, Persaud A, Mukherjee M, Li N, Doye A, Walker JR, Sheng Y, ... ... Chen J, et al. System-Wide Modulation of HECT E3 Ligases with Selective Ubiquitin Variant Probes. Molecular Cell. PMID 26949039 DOI: 10.1016/J.Molcel.2016.02.005  0.308
2016 Wang X, Jung YS, Jun S, Lee S, Wang W, Schneider A, Sun Oh Y, Lin SH, Park BJ, Chen J, Keyomarsi K, Park JI. PAF-Wnt signaling-induced cell plasticity is required for maintenance of breast cancer cell stemness. Nature Communications. 7: 10633. PMID 26843124 DOI: 10.1038/Ncomms10633  0.318
2016 Chen Z, Tran M, Tang M, Wang W, Gong Z, Chen J. Proteomic Analysis Reveals a Novel MutS Partner Involved in Mismatch Repair Pathway. Molecular & Cellular Proteomics : McP. PMID 26828036 DOI: 10.1074/mcp.M115.056093  0.347
2016 Chen J, Shukla V, Chen J, Panditab RK, Jeong YS, Katz LH, Shin J, Gi Y, Kwongc LN, Huntb CR, Farci P, Su X, White J, Mishra B, Rashid A, ... ... Chen J, et al. Abstract 3594: The TGF-β effector β2SP depletion abrogates DNA damage repair Cancer Research. 76: 3594-3594. DOI: 10.1158/1538-7445.Am2016-3594  0.436
2016 Wang L, Zhang P, Molkentine D, Molkentine J, Raju U, Valdecanas D, Tailor R, Thames H, Buchholz T, Chen J, Ma L, Mason K, Meyn R, Skinner HD. Abstract 1661: TRIP12 as a mediator of human papillomavirus/p16-related radiation enhancement effects Cancer Research. 76: 1661-1661. DOI: 10.1158/1538-7445.Am2016-1661  0.352
2015 Feng L, Li N, Li Y, Wang J, Gao M, Wang W, Chen J. Cell cycle-dependent inhibition of 53BP1 signaling by BRCA1. Cell Discovery. 1: 15019. PMID 27462418 DOI: 10.1038/Celldisc.2015.19  0.438
2015 Mu Y, Lou J, Srivastava M, Zhao B, Feng XH, Liu T, Chen J, Huang J. SLFN11 inhibits checkpoint maintenance and homologous recombination repair. Embo Reports. PMID 26658330 DOI: 10.15252/Embr.201540964  0.483
2015 Huen MS, Chen J. H1 provides the missing link. Cell Research. PMID 26596785 DOI: 10.1038/Cr.2015.138  0.386
2015 Wang W, Li N, Li X, Tran MK, Han X, Chen J. Tankyrase Inhibitors Target YAP by Stabilizing Angiomotin Family Proteins. Cell Reports. PMID 26456820 DOI: 10.1016/J.Celrep.2015.09.014  0.336
2015 Sorokin AV, Nair BC, Wei Y, Aziz KE, Evdokimova V, Hung MC, Chen J. Aberrant Expression of proPTPRN2 in Cancer Cells Confers Resistance to Apoptosis. Cancer Research. 75: 1846-58. PMID 25877877 DOI: 10.1158/0008-5472.Can-14-2718  0.349
2015 Tian Y, Paramasivam M, Ghosal G, Chen D, Shen X, Huang Y, Akhter S, Legerski R, Chen J, Seidman MM, Qin J, Li L. UHRF1 contributes to DNA damage repair as a lesion recognition factor and nuclease scaffold. Cell Reports. 10: 1957-66. PMID 25818288 DOI: 10.1016/J.Celrep.2015.03.038  0.452
2015 Wang W, Li X, Lee M, Jun S, Aziz KE, Feng L, Tran MK, Li N, McCrea PD, Park JI, Chen J. FOXKs promote Wnt/β-catenin signaling by translocating DVL into the nucleus. Developmental Cell. 32: 707-18. PMID 25805136 DOI: 10.1016/J.Devcel.2015.01.031  0.302
2015 Xu G, Chapman JR, Brandsma I, Yuan J, Mistrik M, Bouwman P, Bartkova J, Gogola E, Warmerdam D, Barazas M, Jaspers JE, Watanabe K, Pieterse M, Kersbergen A, Sol W, ... ... Chen J, et al. REV7 counteracts DNA double-strand break resection and affects PARP inhibition. Nature. 521: 541-4. PMID 25799992 DOI: 10.1038/Nature14328  0.479
2015 Wang J, Chen J, Gong Z. TopBP1 stabilizes BLM protein to suppress sister chromatid exchange. Molecular Cell. 57: 955-6. PMID 25794614 DOI: 10.1016/J.Molcel.2015.02.011  0.334
2015 Wang W, Xiao ZD, Li X, Aziz KE, Gan B, Johnson RL, Chen J. AMPK modulates Hippo pathway activity to regulate energy homeostasis. Nature Cell Biology. 17: 490-9. PMID 25751139 DOI: 10.1038/Ncb3113  0.311
2015 Li X, Wang W, Wang J, Malovannaya A, Xi Y, Li W, Guerra R, Hawke DH, Qin J, Chen J. Proteomic analyses reveal distinct chromatin-associated and soluble transcription factor complexes. Molecular Systems Biology. 11: 775. PMID 25609649 DOI: 10.15252/Msb.20145504  0.375
2015 Li N, Zhang Y, Han X, Liang K, Wang J, Feng L, Wang W, Songyang Z, Lin C, Yang L, Yu Y, Chen J. Poly-ADP ribosylation of PTEN by tankyrases promotes PTEN degradation and tumor growth. Genes & Development. 29: 157-70. PMID 25547115 DOI: 10.1101/Gad.251785.114  0.394
2014 Wang J, Aroumougame A, Lobrich M, Li Y, Chen D, Chen J, Gong Z. PTIP associates with Artemis to dictate DNA repair pathway choice. Genes & Development. 28: 2693-8. PMID 25512557 DOI: 10.1101/Gad.252478.114  0.487
2014 Barton O, Naumann SC, Diemer-Biehs R, Künzel J, Steinlage M, Conrad S, Makharashvili N, Wang J, Feng L, Lopez BS, Paull TT, Chen J, Jeggo PA, Löbrich M. Polo-like kinase 3 regulates CtIP during DNA double-strand break repair in G1. The Journal of Cell Biology. 206: 877-94. PMID 25267294 DOI: 10.1083/Jcb.201401146  0.458
2014 Cleaver JE, Brennan-Minnella AM, Swanson RA, Fong KW, Chen J, Chou KM, Chen YW, Revet I, Bezrookove V. Mitochondrial reactive oxygen species are scavenged by Cockayne syndrome B protein in human fibroblasts without nuclear DNA damage. Proceedings of the National Academy of Sciences of the United States of America. 111: 13487-92. PMID 25136123 DOI: 10.1073/Pnas.1414135111  0.404
2014 Xu S, Li X, Gong Z, Wang W, Li Y, Nair BC, Piao H, Yang K, Wu G, Chen J. Proteomic analysis of the human cyclin-dependent kinase family reveals a novel CDK5 complex involved in cell growth and migration. Molecular & Cellular Proteomics : McP. 13: 2986-3000. PMID 25096995 DOI: 10.1074/Mcp.M113.036699  0.397
2014 Zhang P, Wei Y, Wang L, Debeb BG, Yuan Y, Zhang J, Yuan J, Wang M, Chen D, Sun Y, Woodward WA, Liu Y, Dean DC, Liang H, Hu Y, ... ... Chen J, et al. ATM-mediated stabilization of ZEB1 promotes DNA damage response and radioresistance through CHK1. Nature Cell Biology. 16: 864-75. PMID 25086746 DOI: 10.1038/Ncb3013  0.401
2014 Huang Y, Leung JW, Lowery M, Matsushita N, Wang Y, Shen X, Huong D, Takata M, Chen J, Li L. Modularized functions of the Fanconi anemia core complex. Cell Reports. 7: 1849-57. PMID 24910428 DOI: 10.1016/J.Celrep.2014.04.029  0.356
2014 Li Y, Fong KW, Tang M, Han X, Gong Z, Ma W, Hebert M, Songyang Z, Chen J. Fam118B, a newly identified component of Cajal bodies, is required for Cajal body formation, snRNP biogenesis and cell viability. Journal of Cell Science. 127: 2029-39. PMID 24569877 DOI: 10.1242/Jcs.143453  0.33
2014 Li N, Chen J. ADP-ribosylation: activation, recognition, and removal. Molecules and Cells. 37: 9-16. PMID 24552704 DOI: 10.14348/Molcells.2014.2245  0.364
2014 Wang W, Li X, Huang J, Feng L, Dolinta KG, Chen J. Defining the protein-protein interaction network of the human hippo pathway. Molecular & Cellular Proteomics : McP. 13: 119-31. PMID 24126142 DOI: 10.1074/Mcp.M113.030049  0.365
2014 Wang L, Zhang P, Molkentine DP, Piao H, Chen C, Molkentine JM, Zhang J, Valdecanas DR, Skinner H, Buchholz TA, Chen J, Ma L, Mason KA, Ang K, Meyn RE. Abstract 4895: P16INK4A, a surrogate marker of HPV infection and prognosis for head and neck cancer, delays DNA damage repair and enhances radiation response Cancer Research. 74: 4895-4895. DOI: 10.1158/1538-7445.Am2014-4895  0.379
2013 Zhang J, Zhang P, Wei Y, Piao HL, Wang W, Maddika S, Wang M, Chen D, Sun Y, Hung MC, Chen J, Ma L. Deubiquitylation and stabilization of PTEN by USP13. Nature Cell Biology. 15: 1486-94. PMID 24270891 DOI: 10.1038/Ncb2874  0.385
2013 Wang J, Chen J, Gong Z. TopBP1 controls BLM protein level to maintain genome stability. Molecular Cell. 52: 667-78. PMID 24239288 DOI: 10.1016/J.Molcel.2013.10.012  0.454
2013 Fong KW, Li Y, Wang W, Ma W, Li K, Qi RZ, Liu D, Songyang Z, Chen J. Whole-genome screening identifies proteins localized to distinct nuclear bodies. The Journal of Cell Biology. 203: 149-64. PMID 24127217 DOI: 10.1083/Jcb.201303145  0.312
2013 Ghosal G, Chen J. DNA damage tolerance: a double-edged sword guarding the genome. Translational Cancer Research. 2: 107-129. PMID 24058901 DOI: 10.3978/J.Issn.2218-676X.2013.04.01  0.475
2013 Wang Y, Han X, Wu F, Leung JW, Lowery MG, Do H, Chen J, Shi C, Tian C, Li L, Gong W. Structure analysis of FAAP24 reveals single-stranded DNA-binding activity and domain functions in DNA damage response. Cell Research. 23: 1215-28. PMID 23999858 DOI: 10.1038/Cr.2013.124  0.471
2013 Leung CC, Sun L, Gong Z, Burkat M, Edwards R, Assmus M, Chen J, Glover JN. Structural insights into recognition of MDC1 by TopBP1 in DNA replication checkpoint control. Structure (London, England : 1993). 21: 1450-9. PMID 23891287 DOI: 10.1016/J.Str.2013.06.015  0.439
2013 Han X, Liu D, Zhang Y, Li Y, Lu W, Chen J, Songyang Z. Akt regulates TPP1 homodimerization and telomere protection. Aging Cell. 12: 1091-9. PMID 23862686 DOI: 10.1111/Acel.12137  0.417
2013 Yuan J, Chen J. FIGNL1-containing protein complex is required for efficient homologous recombination repair. Proceedings of the National Academy of Sciences of the United States of America. 110: 10640-5. PMID 23754376 DOI: 10.1073/pnas.1220662110  0.429
2013 Wang L, Zeng X, Chen S, Ding L, Zhong J, Zhao JC, Wang L, Sarver A, Koller A, Zhi J, Ma Y, Yu J, Chen J, Huang H. BRCA1 is a negative modulator of the PRC2 complex. The Embo Journal. 32: 1584-97. PMID 23624935 DOI: 10.1038/Emboj.2013.95  0.379
2013 Feng L, Fong KW, Wang J, Wang W, Chen J. RIF1 counteracts BRCA1-mediated end resection during DNA repair. The Journal of Biological Chemistry. 288: 11135-43. PMID 23486525 DOI: 10.1074/Jbc.M113.457440  0.501
2013 Wang Y, Leung JW, Jiang Y, Lowery MG, Do H, Vasquez KM, Chen J, Wang W, Li L. FANCM and FAAP24 maintain genome stability via cooperative as well as unique functions. Molecular Cell. 49: 997-1009. PMID 23333308 DOI: 10.1016/J.Molcel.2012.12.010  0.381
2013 Leung JW, Ghosal G, Wang W, Shen X, Wang J, Li L, Chen J. Alpha thalassemia/mental retardation syndrome X-linked gene product ATRX is required for proper replication restart and cellular resistance to replication stress. The Journal of Biological Chemistry. 288: 6342-50. PMID 23329831 DOI: 10.1074/Jbc.M112.411603  0.418
2013 Fong KW, Leung JW, Li Y, Wang W, Feng L, Ma W, Liu D, Songyang Z, Chen J. MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis. Journal of Cell Science. 126: 825-37. PMID 23264731 DOI: 10.1242/Jcs.116137  0.326
2013 Wang J, Leung JW, Gong Z, Feng L, Shi X, Chen J. PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis. The Journal of Biological Chemistry. 288: 3174-83. PMID 23229552 DOI: 10.1074/Jbc.M112.414839  0.456
2013 Yang SH, Zhou R, Campbell J, Chen J, Ha T, Paull TT. The SOSS1 single-stranded DNA binding complex promotes DNA end resection in concert with Exo1. The Embo Journal. 32: 126-39. PMID 23178594 DOI: 10.1038/Emboj.2012.314  0.46
2013 Kavela S, Shinde SR, Ratheesh R, Viswakalyan K, Bashyam MD, Gowrishankar S, Vamsy M, Pattnaik S, Rao S, Sastry RA, Srinivasulu M, Chen J, Maddika S. PNUTS functions as a proto-oncogene by sequestering PTEN. Cancer Research. 73: 205-14. PMID 23117887 DOI: 10.1158/0008-5472.Can-12-1394  0.407
2013 Wang J, Leung JWC, Gong Z, Feng L, Shi X, Chen J. PHF6 regulates cell cycle progression by suppressing ribosomal RNA synthesis Epigenetics & Chromatin. 6. DOI: 10.1186/1756-8935-6-S1-P134  0.456
2013 Yuan J, Chen J. Abstract 620: Defects of homologous recombination repair in breast cancer: Identification of a novel RAD51-associated protein complex. Cancer Research. 73: 620-620. DOI: 10.1158/1538-7445.Am2013-620  0.48
2013 Shukla V, Chen J, Chen J, Li Y, Katz L, Majumdar A, Li L, Hittleman W, Su X, Chen J, Wu X, Farci P, Mishra L. Abstract 1775: High resolution characterization of human hepatocellular cancer (HCC) reveals a novel inactivating mutation in the TGF-β pathway that promotes alcohol induced HCC. Cancer Research. 73: 1775-1775. DOI: 10.1158/1538-7445.Am2013-1775  0.368
2012 Sin HS, Barski A, Zhang F, Kartashov AV, Nussenzweig A, Chen J, Andreassen PR, Namekawa SH. RNF8 regulates active epigenetic modifications and escape gene activation from inactive sex chromosomes in post-meiotic spermatids. Genes & Development. 26: 2737-48. PMID 23249736 DOI: 10.1101/Gad.202713.112  0.344
2012 Ghosal G, Chen J. Alteration/deficiency in activation 3 (ADA3): Regulator of DNA repair and genome stability. Cell Cycle (Georgetown, Tex.). 11: 4496. PMID 23222062 DOI: 10.4161/Cc.22934  0.514
2012 Wang W, Huang J, Wang X, Yuan J, Li X, Feng L, Park JI, Chen J. PTPN14 is required for the density-dependent control of YAP1. Genes & Development. 26: 1959-71. PMID 22948661 DOI: 10.1101/Gad.192955.112  0.386
2012 Ghosal G, Leung JW, Nair BC, Fong KW, Chen J. Proliferating cell nuclear antigen (PCNA)-binding protein C1orf124 is a regulator of translesion synthesis. The Journal of Biological Chemistry. 287: 34225-33. PMID 22902628 DOI: 10.1074/Jbc.M112.400135  0.505
2012 Fei J, Chen J. KIAA1530 protein is recruited by Cockayne syndrome complementation group protein A (CSA) to participate in transcription-coupled repair (TCR). The Journal of Biological Chemistry. 287: 35118-26. PMID 22902626 DOI: 10.1074/Jbc.M112.398131  0.643
2012 Yuan J, Ghosal G, Chen J. The HARP-like domain-containing protein AH2/ZRANB3 binds to PCNA and participates in cellular response to replication stress. Molecular Cell. 47: 410-21. PMID 22705370 DOI: 10.1016/J.Molcel.2012.05.025  0.411
2012 Wu J, Liu C, Chen J, Yu X. RAP80 protein is important for genomic stability and is required for stabilizing BRCA1-A complex at DNA damage sites in vivo. The Journal of Biological Chemistry. 287: 22919-26. PMID 22539352 DOI: 10.1074/Jbc.M112.351007  0.49
2012 Leung JW, Wang Y, Fong KW, Huen MS, Li L, Chen J. Fanconi anemia (FA) binding protein FAAP20 stabilizes FA complementation group A (FANCA) and participates in interstrand cross-link repair. Proceedings of the National Academy of Sciences of the United States of America. 109: 4491-6. PMID 22396592 DOI: 10.1073/Pnas.1118720109  0.486
2012 Feng L, Chen J. The E3 ligase RNF8 regulates KU80 removal and NHEJ repair. Nature Structural & Molecular Biology. 19: 201-6. PMID 22266820 DOI: 10.1038/Nsmb.2211  0.436
2011 Rai R, Li JM, Zheng H, Lok GT, Deng Y, Huen MS, Chen J, Jin J, Chang S. The E3 ubiquitin ligase Rnf8 stabilizes Tpp1 to promote telomere end protection. Nature Structural & Molecular Biology. 18: 1400-7. PMID 22101936 DOI: 10.1038/Nsmb.2172  0.45
2011 Liu T, Chen H, Kim H, Huen MS, Chen J, Huang J. RAD18-BRCTx interaction is required for efficient repair of UV-induced DNA damage. Dna Repair. 11: 131-8. PMID 22036607 DOI: 10.1016/J.Dnarep.2011.10.012  0.513
2011 Liu T, Wan L, Wu Y, Chen J, Huang J. hSWS1·SWSAP1 is an evolutionarily conserved complex required for efficient homologous recombination repair. The Journal of Biological Chemistry. 286: 41758-66. PMID 21965664 DOI: 10.1074/Jbc.M111.271080  0.431
2011 Sy SM, Jiang J, Dong SS, Lok GT, Wu J, Cai H, Yeung ES, Huang J, Chen J, Deng Y, Huen MS. Critical roles of ring finger protein RNF8 in replication stress responses. The Journal of Biological Chemistry. 286: 22355-61. PMID 21558560 DOI: 10.1074/Jbc.M111.232041  0.501
2011 Ichijima Y, Ichijima M, Lou Z, Nussenzweig A, Camerini-Otero RD, Chen J, Andreassen PR, Namekawa SH. MDC1 directs chromosome-wide silencing of the sex chromosomes in male germ cells. Genes & Development. 25: 959-71. PMID 21536735 DOI: 10.1101/Gad.2030811  0.381
2011 Maddika S, Kavela S, Rani N, Palicharla VR, Pokorny JL, Sarkaria JN, Chen J. WWP2 is an E3 ubiquitin ligase for PTEN. Nature Cell Biology. 13: 728-33. PMID 21532586 DOI: 10.1038/Ncb2240  0.406
2011 Ghosal G, Yuan J, Chen J. The HARP domain dictates the annealing helicase activity of HARP/SMARCAL1. Embo Reports. 12: 574-80. PMID 21525954 DOI: 10.1038/Embor.2011.74  0.375
2011 Leung JW, Leitch A, Wood JL, Shaw-Smith C, Metcalfe K, Bicknell LS, Jackson AP, Chen J. SET nuclear oncogene associates with microcephalin/MCPH1 and regulates chromosome condensation. The Journal of Biological Chemistry. 286: 21393-400. PMID 21515671 DOI: 10.1074/Jbc.M110.208793  0.38
2011 Wang J, Gong Z, Chen J. MDC1 collaborates with TopBP1 in DNA replication checkpoint control. The Journal of Cell Biology. 193: 267-73. PMID 21482717 DOI: 10.1083/Jcb.201010026  0.505
2011 Yuan J, Chen J. The role of the human SWI5-MEI5 complex in homologous recombination repair. The Journal of Biological Chemistry. 286: 9888-93. PMID 21252223 DOI: 10.1074/jbc.M110.207290  0.317
2011 Leung CC, Gong Z, Chen J, Glover JN. Molecular basis of BACH1/FANCJ recognition by TopBP1 in DNA replication checkpoint control. The Journal of Biological Chemistry. 286: 4292-301. PMID 21127055 DOI: 10.1074/Jbc.M110.189555  0.426
2010 Sy SM, Chen J, Huen MS. The 53BP1-EXPAND1 connection in chromatin structure regulation. Nucleus (Austin, Tex.). 1: 472-4. PMID 21327088 DOI: 10.4161/Nucl.1.6.13059  0.483
2010 Wang W, Huang J, Chen J. Angiomotin-like proteins associate with and negatively regulate YAP1. The Journal of Biological Chemistry. 286: 4364-70. PMID 21187284 DOI: 10.1074/Jbc.C110.205401  0.405
2010 Dray E, Etchin J, Wiese C, Saro D, Williams GJ, Hammel M, Yu X, Galkin VE, Liu D, Tsai MS, Sy SM, Schild D, Egelman E, Chen J, Sung P. Enhancement of RAD51 recombinase activity by the tumor suppressor PALB2. Nature Structural & Molecular Biology. 17: 1255-9. PMID 20871616 DOI: 10.1038/Nsmb.1916  0.463
2010 Liu T, Ghosal G, Yuan J, Chen J, Huang J. FAN1 acts with FANCI-FANCD2 to promote DNA interstrand cross-link repair. Science (New York, N.Y.). 329: 693-6. PMID 20671156 DOI: 10.1126/Science.1192656  0.49
2010 Feng L, Wang J, Chen J. The Lys63-specific deubiquitinating enzyme BRCC36 is regulated by two scaffold proteins localizing in different subcellular compartments. The Journal of Biological Chemistry. 285: 30982-8. PMID 20656690 DOI: 10.1074/Jbc.M110.135392  0.422
2010 Huen MS, Sy SM, Leung KM, Ching YP, Tipoe GL, Man C, Dong S, Chen J. SON is a spliceosome-associated factor required for mitotic progression. Cell Cycle (Georgetown, Tex.). 9: 2679-85. PMID 20581448 DOI: 10.4161/Cc.9.13.12151  0.353
2010 Huen MS, Chen J. ATM Creates a veil of transcriptional silence. Cell. 141: 924-6. PMID 20550929 DOI: 10.1016/J.Cell.2010.05.035  0.457
2010 Yuan J, Adamski R, Chen J. Focus on histone variant H2AX: to be or not to be. Febs Letters. 584: 3717-24. PMID 20493860 DOI: 10.1016/j.febslet.2010.05.021  0.403
2010 Park G, Gong Z, Chen J, Kim JE. Characterization of the DOT1L network: implications of diverse roles for DOT1L. The Protein Journal. 29: 213-23. PMID 20431927 DOI: 10.1007/S10930-010-9242-8  0.366
2010 Santos MA, Huen MS, Jankovic M, Chen HT, López-Contreras AJ, Klein IA, Wong N, Barbancho JL, Fernandez-Capetillo O, Nussenzweig MC, Chen J, Nussenzweig A. Class switching and meiotic defects in mice lacking the E3 ubiquitin ligase RNF8. The Journal of Experimental Medicine. 207: 973-81. PMID 20385748 DOI: 10.1084/Jem.20092308  0.445
2010 Huen MS, Huang J, Leung JW, Sy SM, Leung KM, Ching YP, Tsao SW, Chen J. Regulation of chromatin architecture by the PWWP domain-containing DNA damage-responsive factor EXPAND1/MUM1. Molecular Cell. 37: 854-64. PMID 20347427 DOI: 10.1016/J.Molcel.2009.12.040  0.492
2010 Gong Z, Kim JE, Leung CC, Glover JN, Chen J. BACH1/FANCJ acts with TopBP1 and participates early in DNA replication checkpoint control. Molecular Cell. 37: 438-46. PMID 20159562 DOI: 10.1016/J.Molcel.2010.01.002  0.476
2010 Becherel OJ, Jakob B, Cherry AL, Gueven N, Fusser M, Kijas AW, Peng C, Katyal S, McKinnon PJ, Chen J, Epe B, Smerdon SJ, Taucher-Scholz G, Lavin MF. CK2 phosphorylation-dependent interaction between aprataxin and MDC1 in the DNA damage response. Nucleic Acids Research. 38: 1489-503. PMID 20008512 DOI: 10.1093/nar/gkp1149  0.379
2010 Richards MW, Leung JW, Roe SM, Li K, Chen J, Bayliss R. A pocket on the surface of the N-terminal BRCT domain of Mcph1 is required to prevent abnormal chromosome condensation. Journal of Molecular Biology. 395: 908-15. PMID 19925808 DOI: 10.1016/J.Jmb.2009.11.029  0.332
2010 Yuan J, Chen J. MRE11-RAD50-NBS1 complex dictates DNA repair independent of H2AX. The Journal of Biological Chemistry. 285: 1097-104. PMID 19910469 DOI: 10.1074/Jbc.M109.078436  0.49
2009 Huen MS, Sy SM, Chen J. BRCA1 and its toolbox for the maintenance of genome integrity. Nature Reviews. Molecular Cell Biology. 11: 138-48. PMID 20029420 DOI: 10.1038/Nrm2831  0.5
2009 Huen MS, Chen J. Assembly of checkpoint and repair machineries at DNA damage sites. Trends in Biochemical Sciences. 35: 101-8. PMID 19875294 DOI: 10.1016/J.Tibs.2009.09.001  0.47
2009 Kim JE, Lou Z, Chen J. Interactions between DBC1 and SIRT 1 are deregulated in breast cancer cells. Cell Cycle (Georgetown, Tex.). 8: 3784-5. PMID 19855164 DOI: 10.4161/Cc.8.22.10055  0.302
2009 Ande SR, Chen J, Maddika S. The ubiquitin pathway: an emerging drug target in cancer therapy. European Journal of Pharmacology. 625: 199-205. PMID 19835866 DOI: 10.1016/J.Ejphar.2009.08.042  0.354
2009 Yuan J, Ghosal G, Chen J. The annealing helicase HARP protects stalled replication forks. Genes & Development. 23: 2394-9. PMID 19793864 DOI: 10.1101/Gad.1836409  0.471
2009 Yuan J, Chen J. N terminus of CtIP is critical for homologous recombination-mediated double-strand break repair. The Journal of Biological Chemistry. 284: 31746-52. PMID 19759395 DOI: 10.1074/Jbc.M109.023424  0.486
2009 Cao L, Xu X, Bunting SF, Liu J, Wang RH, Cao LL, Wu JJ, Peng TN, Chen J, Nussenzweig A, Deng CX, Finkel T. A selective requirement for 53BP1 in the biological response to genomic instability induced by Brca1 deficiency. Molecular Cell. 35: 534-41. PMID 19716796 DOI: 10.1016/J.Molcel.2009.06.037  0.413
2009 Fu Z, Regan K, Zhang L, Muders MH, Thibodeau SN, French A, Wu Y, Kaufmann SH, Lingle WL, Chen J, Tindall DJ. Deficiencies in Chfr and Mlh1 synergistically enhance tumor susceptibility in mice. The Journal of Clinical Investigation. 119: 2714-24. PMID 19690386 DOI: 10.1172/Jci37405  0.401
2009 Huang J, Gong Z, Ghosal G, Chen J. SOSS complexes participate in the maintenance of genomic stability. Molecular Cell. 35: 384-93. PMID 19683501 DOI: 10.1016/J.Molcel.2009.06.011  0.456
2009 Kim JE, Chen J, Lou Z. p30 DBC is a potential regulator of tumorigenesis Cell Cycle (Georgetown, Tex.). 8: 2932-2935. PMID 19657230 DOI: 10.4161/Cc.8.18.9473  0.351
2009 Sy SM, Huen MS, Chen J. MRG15 is a novel PALB2-interacting factor involved in homologous recombination. The Journal of Biological Chemistry. 284: 21127-31. PMID 19553677 DOI: 10.1074/Jbc.C109.023937  0.476
2009 Sy SM, Huen MS, Zhu Y, Chen J. PALB2 regulates recombinational repair through chromatin association and oligomerization. The Journal of Biological Chemistry. 284: 18302-10. PMID 19423707 DOI: 10.1074/Jbc.M109.016717  0.503
2009 Huang J, Huen MS, Kim H, Leung CC, Glover JN, Yu X, Chen J. RAD18 transmits DNA damage signalling to elicit homologous recombination repair. Nature Cell Biology. 11: 592-603. PMID 19396164 DOI: 10.1038/Ncb1865  0.499
2009 Sy SMH, Huen MSY, Chen J. PALB2 is an integral component of the BRCA complex required for homologous recombination repair Proceedings of the National Academy of Sciences of the United States of America. 106: 7155-7160. PMID 19369211 DOI: 10.1073/Pnas.0811159106  0.452
2009 Maddika S, Sy SM, Chen J. Functional interaction between Chfr and Kif22 controls genomic stability. The Journal of Biological Chemistry. 284: 12998-3003. PMID 19321445 DOI: 10.1074/Jbc.M900333200  0.418
2009 Maddika S, Chen J. Protein kinase DYRK2 is a scaffold that facilitates assembly of an E3 ligase. Nature Cell Biology. 11: 409-19. PMID 19287380 DOI: 10.1038/Ncb1848  0.344
2009 Feng L, Huang J, Chen J. MERIT40 facilitates BRCA1 localization and DNA damage repair. Genes & Development. 23: 719-28. PMID 19261748 DOI: 10.1101/Gad.1770609  0.534
2009 Gong Z, Cho YW, Kim JE, Ge K, Chen J. Accumulation of Pax2 transactivation domain interaction protein (PTIP) at sites of DNA breaks via RNF8-dependent pathway is required for cell survival after DNA damage. The Journal of Biological Chemistry. 284: 7284-93. PMID 19124460 DOI: 10.1074/Jbc.M809158200  0.523
2009 Luo K, Yuan J, Chen J, Lou Z. Topoisomerase IIalpha controls the decatenation checkpoint. Nature Cell Biology. 11: 204-10. PMID 19098900 DOI: 10.1038/Ncb1828  0.459
2009 Wu J, Huen MS, Lu LY, Ye L, Dou Y, Ljungman M, Chen J, Yu X. Histone ubiquitination associates with BRCA1-dependent DNA damage response. Molecular and Cellular Biology. 29: 849-60. PMID 19015238 DOI: 10.1128/Mcb.01302-08  0.448
2008 Fu Z, Malureanu L, Huang J, Wang W, Li H, van Deursen JM, Tindall DJ, Chen J. Plk1-dependent phosphorylation of FoxM1 regulates a transcriptional programme required for mitotic progression. Nature Cell Biology. 10: 1076-82. PMID 19160488 DOI: 10.1038/Ncb1767  0.373
2008 Huen MS, Chen J. When loose ends finally meet. Nature Structural & Molecular Biology. 15: 1241-2. PMID 19050718 DOI: 10.1038/Nsmb1208-1241  0.438
2008 Lu LY, Wood JL, Ye L, Minter-Dykhouse K, Saunders TL, Yu X, Chen J. Aurora A is essential for early embryonic development and tumor suppression Journal of Biological Chemistry. 283: 31785-31790. PMID 18801727 DOI: 10.1074/Jbc.M805880200  0.344
2008 Lu LY, Wood JL, Minter-Dykhouse K, Ye L, Saunders TL, Yu X, Chen J. Polo-like kinase 1 is essential for early embryonic development and tumor suppression Molecular and Cellular Biology. 28: 6870-6876. PMID 18794363 DOI: 10.1128/Mcb.00392-08  0.35
2008 Wood JL, Chen J. DNA-damage checkpoints: location, location, location. Trends in Cell Biology. 18: 451-5. PMID 18760607 DOI: 10.1016/J.Tcb.2008.07.006  0.488
2008 Wood JL, Liang Y, Li K, Chen J. Microcephalin/MCPH1 associates with the Condensin II complex to function in homologous recombination repair. The Journal of Biological Chemistry. 283: 29586-92. PMID 18718915 DOI: 10.1074/Jbc.M804080200  0.386
2008 Wu L, Beito T, Chen J. Generation and characterization of novel monoclonal antibodies against human aurora-A. Hybridoma (2005). 27: 313-8. PMID 18707550 DOI: 10.1089/Hyb.2008.0016  0.325
2008 Wu L, Luo K, Lou Z, Chen J. MDC1 regulates intra-S-phase checkpoint by targeting NBS1 to DNA double-strand breaks. Proceedings of the National Academy of Sciences of the United States of America. 105: 11200-5. PMID 18678890 DOI: 10.1073/Pnas.0802885105  0.507
2008 Huen MSY, Huang J, Yuan J, Yamamoto M, Akira S, Ashley C, Xiao W, Chen J. Noncanonical E2 variant-independent function of UBC13 in promoting checkpoint protein assembly Molecular and Cellular Biology. 28: 6104-6112. PMID 18678647 DOI: 10.1128/Mcb.00987-08  0.463
2008 Xu C, Wu L, Cui G, Botuyan MV, Chen J, Mer G. Structure of a second BRCT domain identified in the nijmegen breakage syndrome protein Nbs1 and its function in an MDC1-dependent localization of Nbs1 to DNA damage sites. Journal of Molecular Biology. 381: 361-72. PMID 18582474 DOI: 10.1016/J.Jmb.2008.05.087  0.46
2008 Minter-Dykhouse K, Ward I, Huen MS, Chen J, Lou Z. Distinct versus overlapping functions of MDC1 and 53BP1 in DNA damage response and tumorigenesis. The Journal of Cell Biology. 181: 727-35. PMID 18504301 DOI: 10.1083/Jcb.200801083  0.471
2008 Kim H, Chen J. New players in the BRCA1-mediated DNA damage responsive pathway. Molecules and Cells. 25: 457-61. PMID 18443409  0.408
2008 Huang J, Chen J. VprBP targets Merlin to the Roc1-Cul4A-DDB1 E3 ligase complex for degradation Oncogene. 27: 4056-4064. PMID 18332868 DOI: 10.1038/Onc.2008.44  0.366
2008 Huen MS, Sy SM, van Deursen JM, Chen J. Direct interaction between SET8 and proliferating cell nuclear antigen couples H4-K20 methylation with DNA replication. The Journal of Biological Chemistry. 283: 11073-7. PMID 18319261 DOI: 10.1074/Jbc.C700242200  0.347
2008 Steger DJ, Lefterova MI, Ying L, Stonestrom AJ, Schupp M, Zhuo D, Vakoc AL, Kim JE, Chen J, Lazar MA, Blobel GA, Vakoc CR. DOT1L/KMT4 recruitment and H3K79 methylation are ubiquitously coupled with gene transcription in mammalian cells. Molecular and Cellular Biology. 28: 2825-39. PMID 18285465 DOI: 10.1128/Mcb.02076-07  0.314
2008 Kim JE, Chen J, Lou Z. DBC1 is a negative regulator of SIRT1. Nature. 451: 583-6. PMID 18235501 DOI: 10.1038/Nature06500  0.387
2008 Huen MS, Chen J. The DNA damage response pathways: at the crossroad of protein modifications. Cell Research. 18: 8-16. PMID 18087291 DOI: 10.1038/Cr.2007.109  0.517
2007 Xie A, Hartlerode A, Stucki M, Odate S, Puget N, Kwok A, Nagaraju G, Yan C, Alt FW, Chen J, Jackson SP, Scully R. Distinct roles of chromatin-associated proteins MDC1 and 53BP1 in mammalian double-strand break repair. Molecular Cell. 28: 1045-57. PMID 18158901 DOI: 10.1016/J.Molcel.2007.12.005  0.677
2007 Huen MS, Grant R, Manke I, Minn K, Yu X, Yaffe MB, Chen J. RNF8 transduces the DNA-damage signal via histone ubiquitylation and checkpoint protein assembly. Cell. 131: 901-14. PMID 18001825 DOI: 10.1016/J.Cell.2007.09.041  0.517
2007 Wood JL, Singh N, Mer G, Chen J. MCPH1 functions in an H2AX-dependent but MDC1-independent pathway in response to DNA damage. The Journal of Biological Chemistry. 282: 35416-23. PMID 17925396 DOI: 10.1074/Jbc.M705245200  0.493
2007 Kim H, Chen J. c-Myc interacts with TRF1/PIN2 and regulates telomere length. Biochemical and Biophysical Research Communications. 362: 842-7. PMID 17765874 DOI: 10.1016/J.Bbrc.2007.08.064  0.405
2007 Kim H, Huang J, Chen J. CCDC98 is a BRCA1-BRCT domain-binding protein involved in the DNA damage response. Nature Structural & Molecular Biology. 14: 710-5. PMID 17643122 DOI: 10.1038/Nsmb1277  0.491
2007 Kim H, Chen J, Yu X. Ubiquitin-binding protein RAP80 mediates BRCA1-dependent DNA damage response. Science (New York, N.Y.). 316: 1202-5. PMID 17525342 DOI: 10.1126/Science.1139621  0.514
2007 Ahmed EA, van der Vaart A, Barten A, Kal HB, Chen J, Lou Z, Minter-Dykhouse K, Bartkova J, Bartek J, de Boer P, de Rooij DG. Differences in DNA double strand breaks repair in male germ cell types: Lessons learned from a differential expression of Mdc1 and 53BP1 Dna Repair. 6: 1243-1254. PMID 17376750 DOI: 10.1016/J.Dnarep.2007.02.011  0.442
2007 Reina-San-Martin B, Chen J, Nussenzweig A, Nussenzweig MC. Enhanced intra-switch region recombination during immunoglobulin class switch recombination in 53BP1-/- B cells. European Journal of Immunology. 37: 235-9. PMID 17183606 DOI: 10.1002/Eji.200636789  0.374
2006 Botuyan MV, Lee J, Ward IM, Kim JE, Thompson JR, Chen J, Mer G. Structural basis for the methylation state-specific recognition of histone H4-K20 by 53BP1 and Crb2 in DNA repair. Cell. 127: 1361-73. PMID 17190600 DOI: 10.1016/J.Cell.2006.10.043  0.374
2006 Ward I, Kim JE, Minn K, Chini CC, Mer G, Chen J. The tandem BRCT domain of 53BP1 is not required for its repair function. The Journal of Biological Chemistry. 281: 38472-7. PMID 17043355 DOI: 10.1074/Jbc.M607577200  0.497
2006 Huang H, Regan KM, Lou Z, Chen J, Tindall DJ. CDK2-dependent phosphorylation of FOXO1 as an apoptotic response to DNA damage. Science (New York, N.Y.). 314: 294-7. PMID 17038621 DOI: 10.1126/Science.1130512  0.491
2006 Lai M, Chen J. The role of Vpr in HIV-1 disease progression is independent of its G2 arrest induction function. Cell Cycle (Georgetown, Tex.). 5: 2275-80. PMID 16969134 DOI: 10.4161/Cc.5.19.3317  0.354
2006 Chini CC, Chen J. Repeated phosphopeptide motifs in human Claspin are phosphorylated by Chk1 and mediate Claspin function. The Journal of Biological Chemistry. 281: 33276-82. PMID 16963448 DOI: 10.1074/Jbc.M604373200  0.438
2006 Lou Z, Chen J. Cellular senescence and DNA repair Experimental Cell Research. 312: 2641-2646. PMID 16893723 DOI: 10.1016/J.Yexcr.2006.06.009  0.464
2006 Wu X, Dong X, Liu W, Chen J. Characterization of CHEK2 mutations in prostate cancer. Human Mutation. 27: 742-7. PMID 16835864 DOI: 10.1002/Humu.20321  0.367
2006 Yu X, Fu S, Lai M, Baer R, Chen J. BRCA1 ubiquitinates its phosphorylation-dependent binding partner CtIP. Genes & Development. 20: 1721-6. PMID 16818604 DOI: 10.1101/Gad.1431006  0.401
2006 Kim JE, Minter-Dykhouse K, Chen J. Signaling networks controlled by the MRN complex and MDC1 during early DNA damage responses. Molecular Carcinogenesis. 45: 403-8. PMID 16691596 DOI: 10.1002/Mc.20221  0.479
2006 Chini CCS, Wood J, Chen J. Chk1 is required to maintain Claspin stability Oncogene. 25: 4165-4171. PMID 16501606 DOI: 10.1038/Sj.Onc.1209447  0.483
2006 Franco S, Gostissa M, Zha S, Lombard DB, Murphy MM, Zarrin AA, Yan C, Tepsuporn S, Morales JC, Adams MM, Lou Z, Bassing CH, Manis JP, Chen J, Carpenter PB, et al. H2AX prevents DNA breaks from progressing to chromosome breaks and translocations. Molecular Cell. 21: 201-14. PMID 16427010 DOI: 10.1016/J.Molcel.2006.01.005  0.415
2006 Lou Z, Minter-Dykhouse K, Franco S, Gostissa M, Rivera MA, Celeste A, Manis JP, van Deursen J, Nussenzweig A, Paull TT, Alt FW, Chen J. MDC1 maintains genomic stability by participating in the amplification of ATM-dependent DNA damage signals. Molecular Cell. 21: 187-200. PMID 16427009 DOI: 10.1016/J.Molcel.2005.11.025  0.496
2006 Ramiro AR, Jankovic M, Callen E, Difilippantonio S, Chen HT, McBride KM, Eisenreich TR, Chen J, Dickins RA, Lowe SW, Nussenzweig A, Nussenzweig MC. Role of genomic instability and p53 in AID-induced c-myc-Igh translocations. Nature. 440: 105-9. PMID 16400328 DOI: 10.1038/Nature04495  0.462
2006 Kim JE, McAvoy SA, Smith DI, Chen J. Human TopBP1 ensures genome integrity during normal S phase. Molecular and Cellular Biology. 25: 10907-15. PMID 16314514 DOI: 10.1128/Mcb.25.24.10907-10915.2005  0.5
2005 Lou Z, Chen J. Mammalian DNA damage response pathway Advances in Experimental Medicine and Biology. 570: 425-455. PMID 18727510 DOI: 10.1007/1-4020-3764-3_15  0.46
2005 Lai M, Zimmerman ES, Planelles V, Chen J. Activation of the ATR pathway by human immunodeficiency virus type 1 Vpr involves its direct binding to chromatin in vivo. Journal of Virology. 79: 15443-51. PMID 16306615 DOI: 10.1128/Jvi.79.24.15443-15451.2005  0.459
2005 Ward IM, Difilippantonio S, Minn K, Mueller MD, Molina JR, Yu X, Frisk CS, Ried T, Nussenzweig A, Chen J. 53BP1 cooperates with p53 and functions as a haploinsufficient tumor suppressor in mice Molecular and Cellular Biology. 25: 10079-10086. PMID 16260621 DOI: 10.1128/Mcb.25.22.10079-10086.2005  0.361
2005 Baker DJ, Chen J, van Deursen JM. The mitotic checkpoint in cancer and aging: what have mice taught us? Current Opinion in Cell Biology. 17: 583-9. PMID 16226453 DOI: 10.1016/J.Ceb.2005.09.011  0.343
2005 Karnitz LM, Flatten KS, Wagner JM, Loegering D, Hackbarth JS, Arlander SJ, Vroman BT, Thomas MB, Baek YU, Hopkins KM, Lieberman HB, Chen J, Cliby WA, Kaufmann SH. Gemcitabine-induced activation of checkpoint signaling pathways that affect tumor cell survival. Molecular Pharmacology. 68: 1636-44. PMID 16126823 DOI: 10.1124/Mol.105.012716  0.48
2005 Liu B, Wang J, Chan KM, Tjia WM, Deng W, Guan X, Huang JD, Li KM, Chau PY, Chen DJ, Pei D, Pendas AM, Cadiñanos J, López-Otín C, Tse HF, ... ... Chen J, et al. Genomic instability in laminopathy-based premature aging. Nature Medicine. 11: 780-5. PMID 15980864 DOI: 10.1038/Nm1266  0.474
2005 Lou Z, Minter-Dykhouse K, Chen J. BRCA1 participates in DNA decatenation. Nature Structural & Molecular Biology. 12: 589-93. PMID 15965487 DOI: 10.1038/Nsmb953  0.516
2005 Yu X, Minter-Dykhouse K, Malureanu L, Zhao WM, Zhang D, Merkle CJ, Ward IM, Saya H, Fang G, van Deursen J, Chen J. Chfr is required for tumor suppression and Aurora A regulation. Nature Genetics. 37: 401-6. PMID 15793587 DOI: 10.1038/Ng1538  0.322
2005 Ohashi A, Zdzienicka MZ, Chen J, Couch FJ. Fanconi anemia complementation group D2 (FANCD2) functions independently of BRCA2- and RAD51-associated homologous recombination in response to DNA damage. The Journal of Biological Chemistry. 280: 14877-83. PMID 15671039 DOI: 10.1074/Jbc.M414669200  0.536
2005 Andersen JL, Zimmerman ES, DeHart JL, Murala S, Ardon O, Blackett J, Chen J, Planelles V. ATR and GADD45α mediate HIV-1 Vpr-induced apoptosis Cell Death and Differentiation. 12: 326-334. PMID 15650754 DOI: 10.1038/Sj.Cdd.4401565  0.398
2005 Kim JE, Billadeau DD, Chen J. The tandem BRCT domains of Ect2 are required for both negative and positive regulation of Ect2 in cytokinesis. The Journal of Biological Chemistry. 280: 5733-9. PMID 15545273 DOI: 10.1074/Jbc.M409298200  0.336
2005 Chini CC, Chen J. Claspin, a regulator of Chk1 in DNA replication stress pathway. Dna Repair. 3: 1033-7. PMID 15279790 DOI: 10.1016/J.Dnarep.2004.03.001  0.486
2004 Ward I, Chen J. Early events in the DNA damage response. Current Topics in Developmental Biology. 63: 1-35. PMID 15536012 DOI: 10.1016/S0070-2153(04)63001-8  0.484
2004 Yu X, Chen J. DNA damage-induced cell cycle checkpoint control requires CtIP, a phosphorylation-dependent binding partner of BRCA1 C-terminal domains. Molecular and Cellular Biology. 24: 9478-86. PMID 15485915 DOI: 10.1128/Mcb.24.21.9478-9486.2004  0.479
2004 Zimmerman ES, Chen J, Andersen JL, Ardon O, Dehart JL, Blackett J, Choudhary SK, Camerini D, Nghiem P, Planelles V. Human immunodeficiency virus type 1 Vpr-mediated G2 arrest requires Rad17 and Hus1 and induces nuclear BRCA1 and gamma-H2AX focus formation. Molecular and Cellular Biology. 24: 9286-94. PMID 15485898 DOI: 10.1128/Mcb.24.21.9286-9294.2004  0.431
2004 Lou Z, Chen BP, Asaithamby A, Minter-Dykhouse K, Chen DJ, Chen J. MDC1 regulates DNA-PK autophosphorylation in response to DNA damage. The Journal of Biological Chemistry. 279: 46359-62. PMID 15377652 DOI: 10.1074/Jbc.C400375200  0.492
2004 Sengupta S, Robles AI, Linke SP, Sinogeeva NI, Zhang R, Pedeux R, Ward IM, Celeste A, Nussenzweig A, Chen J, Halazonetis TD, Harris CC. Functional interaction between BLM helicase and 53BP1 in a Chk1-mediated pathway during S-phase arrest. The Journal of Cell Biology. 166: 801-13. PMID 15364958 DOI: 10.1083/Jcb.200405128  0.481
2004 Buscemi G, Perego P, Carenini N, Nakanishi M, Chessa L, Chen J, Khanna K, Delia D. Activation of ATM and Chk2 kinases in relation to the amount of DNA strand breaks. Oncogene. 23: 7691-700. PMID 15361830 DOI: 10.1038/sj.onc.1207986  0.371
2004 Botuyan MV, Nominé Y, Yu X, Juranic N, Macura S, Chen J, Mer G. Structural basis of BACH1 phosphopeptide recognition by BRCA1 tandem BRCT domains. Structure (London, England : 1993). 12: 1137-46. PMID 15242590 DOI: 10.1016/J.Str.2004.06.002  0.431
2004 Lou Z, Chen J. Use of siRNA to study the function of MDC1 in DNA damage responses Methods in Molecular Biology (Clifton, N.J.). 281: 179-187. PMID 15220529 DOI: 10.1385/1-59259-811-0:179  0.438
2004 Ward IM, Reina-San-Martin B, Olaru A, Minn K, Tamada K, Lau JS, Cascalho M, Chen L, Nussenzweig A, Livak F, Nussenzweig MC, Chen J. 53BP1 is required for class switch recombination. The Journal of Cell Biology. 165: 459-64. PMID 15159415 DOI: 10.1083/Jcb.200403021  0.437
2004 Ward IM, Minn K, Chen J. UV-induced ataxia-telangiectasia-mutated and Rad3-related (ATR) activation requires replication stress. The Journal of Biological Chemistry. 279: 9677-80. PMID 14742437 DOI: 10.1074/Jbc.C300554200  0.479
2003 Rodriguez M, Yu X, Chen J, Songyang Z. Phosphopeptide binding specificities of BRCA1 COOH-terminal (BRCT) domains. The Journal of Biological Chemistry. 278: 52914-8. PMID 14578343 DOI: 10.1074/Jbc.C300407200  0.416
2003 Yu X, Chini CC, He M, Mer G, Chen J. The BRCT domain is a phospho-protein binding domain. Science (New York, N.Y.). 302: 639-42. PMID 14576433 DOI: 10.1126/Science.1088753  0.436
2003 Wu X, Chen J. Autophosphorylation of checkpoint kinase 2 at serine 516 is required for radiation-induced apoptosis. The Journal of Biological Chemistry. 278: 36163-8. PMID 12855706 DOI: 10.1074/Jbc.M303795200  0.41
2003 Yamane K, Chen J, Kinsella TJ. Both DNA topoisomerase II-binding protein 1 and BRCA1 regulate the G2-M cell cycle checkpoint. Cancer Research. 63: 3049-53. PMID 12810625  0.356
2003 Merkle CJ, Karnitz LM, Henry-Sánchez JT, Chen J. Cloning and characterization of hCTF18, hCTF8, and hDCC1. Human homologs of a Saccharomyces cerevisiae complex involved in sister chromatid cohesion establishment. The Journal of Biological Chemistry. 278: 30051-6. PMID 12766176 DOI: 10.1074/Jbc.M211591200  0.43
2003 Chini CC, Chen J. Human claspin is required for replication checkpoint control. The Journal of Biological Chemistry. 278: 30057-62. PMID 12766152 DOI: 10.1074/Jbc.M301136200  0.504
2003 Lou Z, Chen J. BRCA proteins and DNA damage checkpoints Frontiers in Bioscience : a Journal and Virtual Library. 8. PMID 12700125 DOI: 10.2741/1127  0.464
2003 Ward IM, Minn K, Jorda KG, Chen J. Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX. The Journal of Biological Chemistry. 278: 19579-82. PMID 12697768 DOI: 10.1074/Jbc.C300117200  0.458
2003 Ward IM, Minn K, van Deursen J, Chen J. p53 Binding protein 53BP1 is required for DNA damage responses and tumor suppression in mice. Molecular and Cellular Biology. 23: 2556-63. PMID 12640136 DOI: 10.1128/Mcb.23.7.2556-2563.2003  0.492
2003 Lou Z, Chini CC, Minter-Dykhouse K, Chen J. Mediator of DNA damage checkpoint protein 1 regulates BRCA1 localization and phosphorylation in DNA damage checkpoint control. The Journal of Biological Chemistry. 278: 13599-602. PMID 12611903 DOI: 10.1074/Jbc.C300060200  0.497
2003 Lou Z, Minter-Dykhouse K, Wu X, Chen J. MDC1 is coupled to activated CHK2 in mammalian DNA damage response pathways. Nature. 421: 957-61. PMID 12607004 DOI: 10.1038/Nature01447  0.509
2002 Fernandez-Capetillo O, Chen HT, Celeste A, Ward I, Romanienko PJ, Morales JC, Naka K, Xia Z, Camerini-Otero RD, Motoyama N, Carpenter PB, Bonner WM, Chen J, Nussenzweig A. DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nature Cell Biology. 4: 993-7. PMID 12447390 DOI: 10.1038/Ncb884  0.496
2002 Yamane K, Wu X, Chen J. A DNA damage-regulated BRCT-containing protein, TopBP1, is required for cell survival. Molecular and Cellular Biology. 22: 555-66. PMID 11756551 DOI: 10.1128/Mcb.22.2.555-566.2002  0.523
2002 Sum EY, Peng B, Yu X, Chen J, Byrne J, Lindeman GJ, Visvader JE. The LIM domain protein LMO4 interacts with the cofactor CtIP and the tumor suppressor BRCA1 and inhibits BRCA1 activity. The Journal of Biological Chemistry. 277: 7849-56. PMID 11751867 DOI: 10.1074/Jbc.M110603200  0.421
2001 Ward IM, Chen J. Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress. The Journal of Biological Chemistry. 276: 47759-62. PMID 11673449 DOI: 10.1074/Jbc.C100569200  0.47
2001 Ward IM, Wu X, Chen J. Threonine 68 of Chk2 is phosphorylated at sites of DNA strand breaks. The Journal of Biological Chemistry. 276: 47755-8. PMID 11668173 DOI: 10.1074/Jbc.C100587200  0.464
2001 Joukov V, Chen J, Fox EA, Green JB, Livingston DM. Functional communication between endogenous BRCA1 and its partner, BARD1, during Xenopus laevis development. Proceedings of the National Academy of Sciences of the United States of America. 98: 12078-83. PMID 11593018 DOI: 10.1073/Pnas.211427098  0.559
2001 Rappold I, Iwabuchi K, Date T, Chen J. Tumor Suppressor P53 Binding Protein 1 (53bp1) Is Involved in DNA Damage–Signaling Pathways Journal of Cell Biology. 153: 613-620. PMID 11331310 DOI: 10.1083/Jcb.153.3.613  0.511
2001 Wu X, Webster SR, Chen J. Characterization of tumor-associated Chk2 mutations. The Journal of Biological Chemistry. 276: 2971-4. PMID 11053450 DOI: 10.1074/Jbc.M009727200  0.454
2000 Wu X, Petrini JH, Heine WF, Weaver DT, Livingston DM, Chen J. Independence of R/M/N focus formation and the presence of intact BRCA1 Science. 289: 11. PMID 10928918 DOI: 10.1126/Science.289.5476.11A  0.592
1999 Scully R, Ganesan S, Vlasakova K, Chen J, Socolovsky M, Livingston DM. Genetic analysis of BRCA1 function in a defined tumor cell line. Molecular Cell. 4: 1093-9. PMID 10635334 DOI: 10.1016/S1097-2765(00)80238-5  0.735
1998 Chen J, Silver DP, Walpita D, Cantor SB, Gazdar AF, Tomlinson G, Couch FJ, Weber BL, Ashley T, Livingston DM, Scully R. Stable interaction between the products of the BRCA1 and BRCA2 tumor suppressor genes in mitotic and meiotic cells. Molecular Cell. 2: 317-28. PMID 9774970 DOI: 10.1016/S1097-2765(00)80276-2  0.723
1998 Geraghty DS, Sucic HB, Chen J, Pederson DS. Evidence that partial unwrapping of DNA from nucleosomes facilitates the binding of heat shock factor following DNA replication in yeast. Journal of Biological Chemistry. 273: 20463-20472. PMID 9685401 DOI: 10.1074/Jbc.273.32.20463  0.403
1998 Saha P, Chen J, Thome KC, Lawlis SJ, Hou ZH, Hendricks M, Parvin JD, Dutta A. Human CDC6/Cdc18 associates with Orc1 and cyclin-cdk and is selectively eliminated from the nucleus at the onset of S phase. Molecular and Cellular Biology. 18: 2758-67. PMID 9566895 DOI: 10.1128/Mcb.18.5.2758  0.42
1997 Scully R, Chen J, Ochs RL, Keegan K, Hoekstra M, Feunteun J, Livingston DM. Dynamic changes of BRCA1 subnuclear location and phosphorylation state are initiated by DNA damage. Cell. 90: 425-35. PMID 9267023 DOI: 10.1016/S0092-8674(00)80503-6  0.757
1997 Scully R, Chen J, Plug A, Xiao Y, Weaver D, Feunteun J, Ashley T, Livingston DM. Association of BRCA1 with Rad51 in mitotic and meiotic cells. Cell. 88: 265-75. PMID 9008167 DOI: 10.1016/S0092-8674(00)81847-4  0.733
1996 Chen J, Saha P, Kornbluth S, Dynlacht BD, Dutta A. Cyclin-binding motifs are essential for the function of p21CIP1. Molecular and Cellular Biology. 16: 4673-82. PMID 8756624 DOI: 10.1128/Mcb.16.9.4673  0.375
1996 Chen J, Peters R, Saha P, Lee P, Theodoras A, Pagano M, Wagner G, Dutta A. A 39 Amino Acid Fragment of the Cell Cycle Regulator p21 Is Sufficient to Bind PCNA and Partially Inhibit DNA Replication in vivo Nucleic Acids Research. 24: 1727-1733. PMID 8649992 DOI: 10.1093/Nar/24.9.1727  0.392
1995 Chen J, Ding M, Pederson DS. Binding of TFIID to the CYC1 TATA boxes in yeast occurs independently of upstream activating sequences. Proceedings of the National Academy of Sciences of the United States of America. 91: 11909-13. PMID 7991556 DOI: 10.1073/Pnas.91.25.11909  0.318
1995 Chen J, Jackson PK, Kirschner MW, Dutta A. Separate domains of p21 involved in the inhibition of Cdk kinase and PCNA. Nature. 374: 386-8. PMID 7885482 DOI: 10.1038/374386A0  0.401
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