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Leah Caroline Thomas Byrne, Ph.D. - Publications

School of Veterinary Medicine, Ophthalmology University of Pennsylvania, Philadelphia, PA, United States 
Viral gene therapy, retinal degeneration

18 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Byrne LC, Day TP, Visel M, Fortuny C, Dalkara D, Merigan WH, Schaffer DV, Flannery JG. In vivo directed evolution of AAV in the primate retina. Jci Insight. PMID 32271719 DOI: 10.1172/jci.insight.135112  0.56
2018 Day TP, Byrne LC, Flannery JG, Schaffer DV. Screening for Neutralizing Antibodies Against Natural and Engineered AAV Capsids in Nonhuman Primate Retinas. Methods in Molecular Biology (Clifton, N.J.). 1715: 239-249. PMID 29188518 DOI: 10.1007/978-1-4939-7522-8_17  0.56
2017 Gaj T, Ojala DS, Ekman FK, Byrne LC, Limsirichai P, Schaffer DV. In vivo genome editing improves motor function and extends survival in a mouse model of ALS. Science Advances. 3: eaar3952. PMID 29279867 DOI: 10.1126/sciadv.aar3952  0.56
2015 Shen SQ, Myers CA, Hughes AE, Byrne LC, Flannery JG, Corbo JC. Massively parallel cis-regulatory analysis in the mammalian central nervous system. Genome Research. PMID 26576614 DOI: 10.1101/gr.193789.115  0.56
2015 Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, et al. Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis. Cell. 161: 817-32. PMID 25957687 DOI: 10.1016/j.cell.2015.03.023  0.56
2015 Xue Y, Shen SQ, Jui J, Rupp AC, Byrne LC, Hattar S, Flannery JG, Corbo JC, Kefalov VJ. CRALBP supports the mammalian retinal visual cycle and cone vision. The Journal of Clinical Investigation. 125: 727-38. PMID 25607845 DOI: 10.1172/JCI79651  0.56
2015 Byrne LC, Dalkara D, Luna G, Fisher SK, Clérin E, Sahel JA, Léveillard T, Flannery JG. Viral-mediated RdCVF and RdCVFL expression protects cone and rod photoreceptors in retinal degeneration. The Journal of Clinical Investigation. 125: 105-16. PMID 25415434 DOI: 10.1172/JCI65654  0.56
2015 Byrne LC, Lin YJ, Lee T, Schaffer DV, Flannery JG. The expression pattern of systemically injected AAV9 in the developing mouse retina is determined by age. Molecular Therapy : the Journal of the American Society of Gene Therapy. 23: 290-6. PMID 25224467 DOI: 10.1038/mt.2014.181  0.56
2015 Aït-Ali N, Fridlich R, Millet-Puel G, Clérin E, Delalande F, Jaillard C, Blond F, Perrocheau L, Reichman S, Byrne LC, Olivier-Bandini A, Bellalou J, Moyse E, Bouillaud F, Nicol X, et al. Rod-derived cone viability factor promotes cone survival by stimulating aerobic glycolysis Cell. 161: 817-832. DOI: 10.1016/j.cell.2015.03.023  0.56
2014 Byrne LC, Oztürk BE, Lee T, Fortuny C, Visel M, Dalkara D, Schaffer DV, Flannery JG. Retinoschisin gene therapy in photoreceptors, Müller glia or all retinal cells in the Rs1h-/- mouse. Gene Therapy. 21: 585-92. PMID 24694538 DOI: 10.1038/gt.2014.31  0.56
2014 Day TP, Byrne LC, Schaffer DV, Flannery JG. Advances in AAV vector development for gene therapy in the retina. Advances in Experimental Medicine and Biology. 801: 687-93. PMID 24664759 DOI: 10.1007/978-1-4614-3209-8_86  0.56
2013 Byrne LC, Khalid F, Lee T, Zin EA, Greenberg KP, Visel M, Schaffer DV, Flannery JG. AAV-mediated, optogenetic ablation of Müller Glia leads to structural and functional changes in the mouse retina. Plos One. 8: e76075. PMID 24086689 DOI: 10.1371/journal.pone.0076075  0.56
2013 Dalkara D, Byrne LC, Klimczak RR, Visel M, Yin L, Merigan WH, Flannery JG, Schaffer DV. In vivo-directed evolution of a new adeno-associated virus for therapeutic outer retinal gene delivery from the vitreous. Science Translational Medicine. 5: 189ra76. PMID 23761039 DOI: 10.1126/scitranslmed.3005708  0.56
2012 Dalkara D, Byrne LC, Lee T, Hoffmann NV, Schaffer DV, Flannery JG. Enhanced gene delivery to the neonatal retina through systemic administration of tyrosine-mutated AAV9. Gene Therapy. 19: 176-81. PMID 22011645 DOI: 10.1038/gt.2011.163  0.56
2004 Byrne LC, Zhou Z, Tryggvason K, Hökfelt T, Fetissov SO. Altered NPY and AgRP in membrane type-1 matrix metalloproteinase-deficient mice. Neuroreport. 15: 569-74. PMID 15094525 DOI: 10.1097/00001756-200403010-00037  0.56
2004 Fetissov SO, Byrne LC, Hassani H, Ernfors P, Hökfelt T. Characterization of neuropeptide Y Y2 and Y5 receptor expression in the mouse hypothalamus. The Journal of Comparative Neurology. 470: 256-65. PMID 14755515 DOI: 10.1002/cne.11047  0.56
2003 Fetissov SO, Xu ZQ, Byrne LC, Hassani H, Ernfors P, Hökfelt T. Neuropeptide y targets in the hypothalamus: nitric oxide synthesizing neurones express Y1 receptor. Journal of Neuroendocrinology. 15: 754-60. PMID 12834436  0.56
1989 McBride AA, Byrne LC, Howley PM. E2 polypeptides encoded by bovine papillomavirus type 1 form dimers through the common carboxyl-terminal domain: Transactivation is mediated by the conserved amino-terminal domain Proceedings of the National Academy of Sciences of the United States of America. 86: 510-514. PMID 2536165 DOI: 10.1073/pnas.86.2.510  0.56
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