Akira Nakai - Publications

Affiliations: 
1991-1993 Biochemistry Yamaguchi University Graduate School of Medicine 

127 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Fujimoto M, Takii R, Nakai A. Regulation of HSF1 transcriptional complexes under proteotoxic stress: Mechanisms of heat shock gene transcription involve the stress-induced HSF1 complex formation, changes in chromatin states, and formation of phase-separated condensates. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. e2300036. PMID 37092382 DOI: 10.1002/bies.202300036  0.413
2023 Okada M, Fujimoto M, Srivastava P, Pandey A, Takii R, Nakai A. The Mediator subunit MED12 promotes formation of HSF1 condensates on heat shock response element arrays in heat-shocked cells. Febs Letters. PMID 36971000 DOI: 10.1002/1873-3468.14617  0.477
2022 Kose S, Imai K, Watanabe A, Nakai A, Suzuki Y, Imamoto N. Lack of Hikeshi activates HSF1 activity under normal conditions and disturbs the heat-shock response. Life Science Alliance. 5. PMID 35580988 DOI: 10.26508/lsa.202101241  0.468
2021 Srivastava P, Takii R, Okada M, Fujimoto M, Nakai A. MED12 interacts with the heat shock transcription factor HSF1 and recruits CDK8 to promote the heat shock response in mammalian cells. Febs Letters. PMID 34056708 DOI: 10.1002/1873-3468.14139  0.46
2020 Katiyar A, Fujimoto M, Tan K, Kurashima A, Srivastava P, Okada M, Takii R, Nakai A. HSF1 is required for induction of mitochondrial chaperones during the mitochondrial unfolded protein response. Febs Open Bio. PMID 32302062 DOI: 10.1002/2211-5463.12863  0.307
2019 Takii R, Fujimoto M, Matsumoto M, Srivastava P, Katiyar A, Nakayama KI, Nakai A. The pericentromeric protein shugoshin 2 cooperates with HSF1 in heat shock response and RNA Pol II recruitment. The Embo Journal. e102566. PMID 31657478 DOI: 10.15252/Embj.2019102566  0.522
2019 Shao J, Han B, Cao P, Zhang B, Liu M, Li D, Zhou N, Hao Q, Duan X, Chang Y, Nakai A, Fan Y, Tan K. HSF1 phosphorylation by cyclosporin A confers hyperthermia sensitivity through suppression of HSP expression. Biochimica Et Biophysica Acta. Gene Regulatory Mechanisms. PMID 31054961 DOI: 10.1016/J.Bbagrm.2019.04.009  0.553
2019 Taufiq F, Maharani N, Li P, Kurata Y, Ikeda N, Kuwabara M, Otani N, Miake J, Hasegawa A, Tsuneto M, Shirayoshi Y, Ninomiya H, Saitoh T, Nakai A, Yamamoto K, et al. Uric Acid-Induced Enhancements of Kv1.5 Protein Expression and Channel Activity via the Akt-HSF1-Hsp70 Pathway in HL-1 Atrial Myocytes. Circulation Journal : Official Journal of the Japanese Circulation Society. PMID 30787218 DOI: 10.1253/Circj.Cj-18-1088  0.331
2018 Fujimoto M, Takii R, Katiyar A, Srivastava P, Nakai A. PARP1 promotes the human heat shock response by facilitating HSF1 binding to DNA. Molecular and Cellular Biology. PMID 29661921 DOI: 10.1128/Mcb.00051-18  0.561
2018 Oda T, Sekimoto T, Kurashima K, Fujimoto M, Nakai A, Yamashita T. Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts. Journal of Cell Science. 131. PMID 29632240 DOI: 10.1242/Jcs.210724  0.449
2017 Fujimoto M, Takii R, Takaki E, Katiyar A, Nakato R, Shirahige K, Nakai A. The HSF1-PARP13-PARP1 complex facilitates DNA repair and promotes mammary tumorigenesis. Nature Communications. 8: 1638. PMID 29158484 DOI: 10.1038/S41467-017-01807-7  0.326
2017 Takii R, Fujimoto M, Matsuura Y, Wu F, Oshibe N, Takaki E, Katiyar A, Akashi H, Makino T, Kawata M, Nakai A. HSF1 and HSF3 cooperatively regulate the heat shock response in lizards. Plos One. 12: e0180776. PMID 28686674 DOI: 10.1371/Journal.Pone.0180776  0.587
2017 Oka S, Shiraishi K, Fujimoto M, Katiyar A, Takii R, Nakai A, Matsuyama H. Role of Heat Shock Factor 1 in Conserving Cholesterol Transportation in Leydig Cell Steroidogenesis via Steroidogenic Acute Regulatory Protein. Endocrinology. 158: 2648-2658. PMID 28575284 DOI: 10.1210/En.2017-00132  0.501
2017 Ishii S, Torii M, Son AI, Rajendraprasad M, Morozov YM, Kawasawa YI, Salzberg AC, Fujimoto M, Brennand K, Nakai A, Mezger V, Gage FH, Rakic P, Hashimoto-Torii K. Variations in brain defects result from cellular mosaicism in the activation of heat shock signalling. Nature Communications. 8: 15157. PMID 28462912 DOI: 10.1038/Ncomms15157  0.36
2016 Mahati E, Li P, Kurata Y, Maharani N, Ikeda N, Sakata S, Ogura K, Miake J, Aiba T, Shimizu W, Nakasone N, Ninomiya H, Higaki K, Yamamoto K, Nakai A, et al. M3 Muscarinic Receptor Signaling Stabilizes a Novel Mutant Human Ether-a-Go-Go-Related Gene Channel Protein via Phosphorylation of Heat Shock Factor 1 in Transfected Cells. Circulation Journal : Official Journal of the Japanese Circulation Society. 80: 2443-2452. PMID 27803431 DOI: 10.1253/Circj.Cj-16-0712  0.45
2016 Kondo T, Hisatome I, Yoshimura S, Mahati E, Notsu T, Li P, Iitsuka K, Kato M, Ogura K, Miake J, Aiba T, Shimizu W, Kurata Y, Sakata S, Nakasone N, ... ... Nakai A, et al. Characterization of the novel mutant A78T-HERG from a long QT syndrome type 2 patient: Instability of the mutant protein and stabilization by heat shock factor 1. Journal of Arrhythmia. 32: 433-440. PMID 27761169 DOI: 10.1016/J.Joa.2015.10.005  0.396
2016 Nakai A. Molecular basis of HSF regulation. Nature Structural & Molecular Biology. 23: 93-5. PMID 26840894 DOI: 10.1038/Nsmb.3165  0.304
2015 Ohno Y, Egawa T, Yokoyama S, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Goto K. Deficiency of heat shock transcription factor 1 suppresses heat stress-associated increase in slow soleus muscle mass of mice. Acta Physiologica (Oxford, England). PMID 26347147 DOI: 10.1111/Apha.12600  0.483
2015 Saito K, Kukita K, Kutomi G, Okuya K, Asanuma H, Tabeya T, Naishiro Y, Yamamoto M, Takahashi H, Torigoe T, Nakai A, Shinomura Y, Hirata K, Sato N, Tamura Y. Heat shock protein 90 associates with Toll-like receptors 7/9 and mediates self-nucleic acid recognition in SLE. European Journal of Immunology. 45: 2028-41. PMID 25871979 DOI: 10.1002/Eji.201445293  0.402
2015 Fujimoto M, Takii R, Hayashida N, Nakai A. Analysis of the heat shock factor complex in mammalian HSP70 promoter. Methods in Molecular Biology (Clifton, N.J.). 1292: 53-65. PMID 25804747 DOI: 10.1007/978-1-4939-2522-3_4  0.565
2015 Tan K, Fujimoto M, Takii R, Takaki E, Hayashida N, Nakai A. Mitochondrial SSBP1 protects cells from proteotoxic stresses by potentiating stress-induced HSF1 transcriptional activity. Nature Communications. 6: 6580. PMID 25762445 DOI: 10.1038/Ncomms7580  0.404
2015 Kagawa Y, Yasumoto Y, Sharifi K, Ebrahimi M, Islam A, Miyazaki H, Yamamoto Y, Sawada T, Kishi H, Kobayashi S, Maekawa M, Yoshikawa T, Takaki E, Nakai A, Kogo H, et al. Fatty acid-binding protein 7 regulates function of caveolae in astrocytes through expression of caveolin-1. Glia. 63: 780-94. PMID 25601031 DOI: 10.1002/Glia.22784  0.305
2015 Takii R, Fujimoto M, Tan K, Takaki E, Hayashida N, Nakato R, Shirahige K, Nakai A. ATF1 modulates the heat shock response by regulating the stress-inducible heat shock factor 1 transcription complex. Molecular and Cellular Biology. 35: 11-25. PMID 25312646 DOI: 10.1128/Mcb.00754-14  0.568
2014 Nakamura Y, Fujimoto M, Fukushima S, Nakamura A, Hayashida N, Takii R, Takaki E, Nakai A, Muto M. Heat shock factor 1 is required for migration and invasion of human melanoma in vitro and in vivo. Cancer Letters. 354: 329-35. PMID 25194503 DOI: 10.1016/J.Canlet.2014.08.029  0.471
2014 Hashimoto-Torii K, Torii M, Fujimoto M, Nakai A, El Fatimy R, Mezger V, Ju MJ, Ishii S, Chao SH, Brennand KJ, Gage FH, Rakic P. Roles of heat shock factor 1 in neuronal response to fetal environmental risks and its relevance to brain disorders. Neuron. 82: 560-72. PMID 24726381 DOI: 10.1016/J.Neuron.2014.03.002  0.334
2014 Chuma M, Sakamoto N, Nakai A, Hige S, Nakanishi M, Natsuizaka M, Suda G, Sho T, Hatanaka K, Matsuno Y, Yokoo H, Kamiyama T, Taketomi A, Fujii G, Tashiro K, et al. Heat shock factor 1 accelerates hepatocellular carcinoma development by activating nuclear factor-κB/mitogen-activated protein kinase. Carcinogenesis. 35: 272-81. PMID 24130164 DOI: 10.1093/Carcin/Bgt343  0.414
2013 Nishizawa S, Koya T, Ohno Y, Goto A, Ikuita A, Suzuki M, Ohira T, Egawa T, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Beppu M, Goto K. Regeneration of injured skeletal muscle in heat shock transcription factor 1-null mice. Physiological Reports. 1: e00071. PMID 24303143 DOI: 10.1002/Phy2.71  0.359
2013 Koya T, Nishizawa S, Ohno Y, Goto A, Ikuta A, Suzuki M, Ohira T, Egawa T, Nakai A, Sugiura T, Ohira Y, Yoshioka T, Beppu M, Goto K. Heat shock transcription factor 1-deficiency attenuates overloading-associated hypertrophy of mouse soleus muscle. Plos One. 8: e77788. PMID 24167582 DOI: 10.1371/Journal.Pone.0077788  0.349
2013 Prakasam R, Fujimoto M, Takii R, Hayashida N, Takaki E, Tan K, Wu F, Inouye S, Nakai A. Chicken IL-6 is a heat-shock gene. Febs Letters. 587: 3541-7. PMID 24055475 DOI: 10.1016/J.Febslet.2013.09.012  0.351
2013 Iwai C, Li P, Kurata Y, Hoshikawa Y, Morikawa K, Maharani N, Higaki K, Sasano T, Notsu T, Ishido Y, Miake J, Yamamoto Y, Shirayoshi Y, Ninomiya H, Nakai A, et al. Hsp90 prevents interaction between CHIP and HERG proteins to facilitate maturation of wild-type and mutant HERG proteins. Cardiovascular Research. 100: 520-8. PMID 23963841 DOI: 10.1093/Cvr/Cvt200  0.439
2013 Kondo N, Katsuno M, Adachi H, Minamiyama M, Doi H, Matsumoto S, Miyazaki Y, Iida M, Tohnai G, Nakatsuji H, Ishigaki S, Fujioka Y, Watanabe H, Tanaka F, Nakai A, et al. Heat shock factor-1 influences pathological lesion distribution of polyglutamine-induced neurodegeneration Nature Communications. 4. PMID 23360996 DOI: 10.1038/Ncomms2417  0.533
2013 Lennikov A, Kitaichi N, Kase S, Noda K, Horie Y, Nakai A, Ohno S, Ishida S. Induction of heat shock protein 70 ameliorates ultraviolet-induced photokeratitis in mice. International Journal of Molecular Sciences. 14: 2175-89. PMID 23340653 DOI: 10.3390/Ijms14012175  0.448
2013 Akagi R, Ohno M, Matsubara K, Fujimoto M, Nakai A, Inouye S. Glutamine protects intestinal barrier function of colon epithelial cells from ethanol by modulating Hsp70 expression. Pharmacology. 91: 104-11. PMID 23328693 DOI: 10.1159/000345930  0.443
2012 Fujimoto M, Takaki E, Takii R, Tan K, Prakasam R, Hayashida N, Iemura S, Natsume T, Nakai A. RPA assists HSF1 access to nucleosomal DNA by recruiting histone chaperone FACT. Molecular Cell. 48: 182-94. PMID 22940245 DOI: 10.1016/J.Molcel.2012.07.026  0.484
2012 Kubo M, Li TS, Kurazumi H, Takemoto Y, Ohshima M, Yamamoto Y, Nishimoto A, Mikamo A, Fujimoto M, Nakai A, Hamano K. Heat shock factor 1 contributes to ischemia-induced angiogenesis by regulating the mobilization and recruitment of bone marrow stem/progenitor cells. Plos One. 7: e37934. PMID 22655083 DOI: 10.1371/Journal.Pone.0037934  0.334
2012 Ma H, Gong H, Chen Z, Liang Y, Yuan J, Zhang G, Wu J, Ye Y, Yang C, Nakai A, Komuro I, Ge J, Zou Y. Association of Stat3 with HSF1 plays a critical role in G-CSF-induced cardio-protection against ischemia/reperfusion injury. Journal of Molecular and Cellular Cardiology. 52: 1282-90. PMID 22426029 DOI: 10.1016/J.Yjmcc.2012.02.011  0.334
2012 Nakamoto T, Mikuriya T, Sugahara K, Hirose Y, Hashimoto T, Shimogori H, Takii R, Nakai A, Yamashita H. Geranylgeranylacetone suppresses noise-induced expression of proinflammatory cytokines in the cochlea. Auris, Nasus, Larynx. 39: 270-4. PMID 21794995 DOI: 10.1016/J.Anl.2011.06.001  0.458
2011 Zou Y, Li J, Ma H, Jiang H, Yuan J, Gong H, Liang Y, Guan A, Wu J, Li L, Zhou N, Niu Y, Sun A, Nakai A, Wang P, et al. Heat shock transcription factor 1 protects heart after pressure overload through promoting myocardial angiogenesis in male mice Journal of Molecular and Cellular Cardiology. 51: 821-829. PMID 21854784 DOI: 10.1016/J.Yjmcc.2011.07.030  0.336
2011 Yasuhara K, Ohno Y, Kojima A, Uehara K, Beppu M, Sugiura T, Fujimoto M, Nakai A, Ohira Y, Yoshioka T, Goto K. Absence of heat shock transcription factor 1 retards the regrowth of atrophied soleus muscle in mice. Journal of Applied Physiology (Bethesda, Md. : 1985). 111: 1142-9. PMID 21817109 DOI: 10.1152/Japplphysiol.00471.2011  0.391
2011 Shinkawa T, Tan K, Fujimoto M, Hayashida N, Yamamoto K, Takaki E, Takii R, Prakasam R, Inouye S, Mezger V, Nakai A. Heat shock factor 2 is required for maintaining proteostasis against febrile-range thermal stress and polyglutamine aggregation. Molecular Biology of the Cell. 22: 3571-83. PMID 21813737 DOI: 10.1091/Mbc.E11-04-0330  0.582
2011 Hayashida N, Fujimoto M, Nakai A. Transcription factor cooperativity with heat shock factor 1. Transcription. 2: 91-94. PMID 21468236 DOI: 10.4161/trns.2.2.14962  0.469
2011 Hatori M, Hirota T, Iitsuka M, Kurabayashi N, Haraguchi S, Kokame K, Sato R, Nakai A, Miyata T, Tsutsui K, Fukada Y. Light-dependent and circadian clock-regulated activation of sterol regulatory element-binding protein, X-box-binding protein 1, and heat shock factor pathways. Proceedings of the National Academy of Sciences of the United States of America. 108: 4864-9. PMID 21383147 DOI: 10.1073/Pnas.1015959108  0.384
2011 Ting Y, Morikawa K, Kurata Y, Li P, Bahrudin U, Mizuta E, Kato M, Miake J, Yamamoto Y, Yoshida A, Murata M, Inoue T, Nakai A, Shiota G, Higaki K, et al. Transcriptional activation of the anchoring protein SAP97 by heat shock factor (HSF)‐1 stabilizes Kv1.5 channels in HL‐1 cells British Journal of Pharmacology. 162: 1832-1842. PMID 21232033 DOI: 10.1111/J.1476-5381.2011.01204.X  0.503
2011 Uchida S, Hara K, Kobayashi A, Fujimoto M, Otsuki K, Yamagata H, Hobara T, Abe N, Higuchi F, Shibata T, Hasegawa S, Kida S, Nakai A, Watanabe Y. Impaired hippocampal spinogenesis and neurogenesis and altered affective behavior in mice lacking heat shock factor 1. Proceedings of the National Academy of Sciences of the United States of America. 108: 1681-6. PMID 21205885 DOI: 10.1073/Pnas.1016424108  0.36
2011 Li P, Ninomiya H, Kurata Y, Kato M, Miake J, Yamamoto Y, Igawa O, Nakai A, Higaki K, Toyoda F, Wu J, Horie M, Matsuura H, Yoshida A, Shirayoshi Y, et al. Reciprocal control of hERG stability by Hsp70 and Hsc70 with implication for restoration of LQT2 mutant stability. Circulation Research. 108: 458-68. PMID 21183741 DOI: 10.1161/Circresaha.110.227835  0.508
2010 He S, Pirity MK, Wang WL, Wolf L, Chauhan BK, Cveklova K, Tamm ER, Ashery-Padan R, Metzger D, Nakai A, Chambon P, Zavadil J, Cvekl A. Chromatin remodeling enzyme Brg1 is required for mouse lens fiber cell terminal differentiation and its denucleation. Epigenetics & Chromatin. 3: 21. PMID 21118511 DOI: 10.1186/1756-8935-3-21  0.346
2010 Nakamura Y, Fujimoto M, Hayashida N, Takii R, Nakai A, Muto M. Silencing HSF1 by short hairpin RNA decreases cell proliferation and enhances sensitivity to hyperthermia in human melanoma cell lines. Journal of Dermatological Science. 60: 187-92. PMID 21044828 DOI: 10.1016/J.Jdermsci.2010.09.009  0.537
2010 Fujimoto M, Nakai A. The heat shock factor family and adaptation to proteotoxic stress. The Febs Journal. 277: 4112-25. PMID 20945528 DOI: 10.1111/J.1742-4658.2010.07827.X  0.568
2010 Nakai A. Novel aspects of heat shock factors. The Febs Journal. 277: 4111. PMID 20945527 DOI: 10.1111/J.1742-4658.2010.07826.X  0.503
2010 Hayashida N, Fujimoto M, Tan K, Prakasam R, Shinkawa T, Li L, Ichikawa H, Takii R, Nakai A. Heat shock factor 1 ameliorates proteotoxicity in cooperation with the transcription factor NFAT. The Embo Journal. 29: 3459-69. PMID 20834230 DOI: 10.1038/Emboj.2010.225  0.516
2010 Ichiyanagi T, Imai T, Kajiwara C, Mizukami S, Nakai A, Nakayama T, Udono H. Essential role of endogenous heat shock protein 90 of dendritic cells in antigen cross-presentation. Journal of Immunology (Baltimore, Md. : 1950). 185: 2693-700. PMID 20668218 DOI: 10.4049/Jimmunol.1000821  0.418
2010 Takii R, Inouye S, Fujimoto M, Nakamura T, Shinkawa T, Prakasam R, Tan K, Hayashida N, Ichikawa H, Hai T, Nakai A. Heat shock transcription factor 1 inhibits expression of IL-6 through activating transcription factor 3. Journal of Immunology (Baltimore, Md. : 1950). 184: 1041-8. PMID 20018623 DOI: 10.4049/Jimmunol.0902579  0.458
2010 Fujimoto M, Hayashida N, Katoh T, Oshima K, Shinkawa T, Prakasam R, Tan K, Inouye S, Takii R, Nakai A. A novel mouse HSF3 has the potential to activate nonclassical heat-shock genes during heat shock. Molecular Biology of the Cell. 21: 106-16. PMID 19864465 DOI: 10.1091/Mbc.E09-07-0639  0.554
2009 Adachi M, Liu Y, Fujii K, Calderwood SK, Nakai A, Imai K, Shinomura Y. Oxidative stress impairs the heat stress response and delays unfolded protein recovery. Plos One. 4: e7719. PMID 19936221 DOI: 10.1371/Journal.Pone.0007719  0.474
2009 Nakai A. Heat shock transcription factors and sensory placode development. Bmb Reports. 42: 631-5. PMID 19874706 DOI: 10.5483/Bmbrep.2009.42.10.631  0.528
2009 Fujimoto M, Nakai A. Heat shock response and homeostasis Seikagaku. 81: 465-473. PMID 19618870  0.394
2009 Suemasu S, Tanaka K, Namba T, Ishihara T, Katsu T, Fujimoto M, Adachi H, Sobue G, Takeuchi K, Nakai A, Mizushima T. A role for HSP70 in protecting against indomethacin-induced gastric lesions. The Journal of Biological Chemistry. 284: 19705-15. PMID 19439408 DOI: 10.1074/Jbc.M109.006817  0.382
2009 Tateishi Y, Ariyoshi M, Igarashi R, Hara H, Mizuguchi K, Seto A, Nakai A, Kokubo T, Tochio H, Shirakawa M. Molecular basis for SUMOylation-dependent regulation of DNA binding activity of heat shock factor 2. The Journal of Biological Chemistry. 284: 2435-47. PMID 19017645 DOI: 10.1074/Jbc.M806392200  0.421
2008 Fujimoto M, Oshima K, Shinkawa T, Wang BB, Inouye S, Hayashida N, Takii R, Nakai A. Analysis of HSF4 binding regions reveals its necessity for gene regulation during development and heat shock response in mouse lenses. The Journal of Biological Chemistry. 283: 29961-70. PMID 18755693 DOI: 10.1074/Jbc.M804629200  0.534
2008 Hirota Y, Kurata Y, Kato M, Notsu T, Koshida S, Inoue T, Kawata Y, Miake J, Bahrudin U, Li P, Hoshikawa Y, Yamamoto Y, Igawa O, Shirayoshi Y, Nakai A, et al. Functional stabilization of Kv1.5 protein by Hsp70 in mammalian cell lines. Biochemical and Biophysical Research Communications. 372: 469-74. PMID 18502196 DOI: 10.1016/J.Bbrc.2008.05.068  0.496
2008 Mikuriya T, Sugahara K, Sugimoto K, Fujimoto M, Takemoto T, Hashimoto M, Hirose Y, Shimogori H, Hayashida N, Inouye S, Nakai A, Yamashita H. Attenuation of progressive hearing loss in a model of age-related hearing loss by a heat shock protein inducer, geranylgeranylacetone. Brain Research. 1212: 9-17. PMID 18445491 DOI: 10.1016/J.Brainres.2008.03.031  0.489
2008 Li J, Ge J, Yuan J, Jiang H, Ma H, Liang Y, Niu Y, Gong H, Zhou N, Guan A, Ma Z, Yuan L, Sun A, Wang Y, Nakai A, et al. Heat shock transcription factor 1 preserves cardiac angiogenesis and adaptation during pressure overload Nature Precedings. DOI: 10.1038/Npre.2008.2716.1  0.439
2007 Takaki E, Fujimoto M, Nakahari T, Yonemura S, Miyata Y, Hayashida N, Yamamoto K, Vallee RB, Mikuriya T, Sugahara K, Yamashita H, Inouye S, Nakai A. Heat shock transcription factor 1 is required for maintenance of ciliary beating in mice. The Journal of Biological Chemistry. 282: 37285-92. PMID 17965413 DOI: 10.1074/Jbc.M704562200  0.525
2007 Inouye S, Fujimoto M, Nakamura T, Takaki E, Hayashida N, Hai T, Nakai A. Heat shock transcription factor 1 opens chromatin structure of interleukin-6 promoter to facilitate binding of an activator or a repressor. The Journal of Biological Chemistry. 282: 33210-7. PMID 17766920 DOI: 10.1074/Jbc.M704471200  0.422
2007 Tanaka K, Namba T, Arai Y, Fujimoto M, Adachi H, Sobue G, Takeuchi K, Nakai A, Mizushima T. Genetic evidence for a protective role for heat shock factor 1 and heat shock protein 70 against colitis. The Journal of Biological Chemistry. 282: 23240-52. PMID 17556362 DOI: 10.1074/Jbc.M704081200  0.468
2007 Tanaka KI, Tsutsumi S, Arai Y, Hoshino T, Suzuki K, Takaki E, Ito T, Takeuchi K, Nakai A, Mizushima T. Genetic evidence for a protective role of heat shock factor 1 against irritant-induced gastric lesions Molecular Pharmacology. 71: 985-993. PMID 17189318 DOI: 10.1124/Mol.106.033282  0.409
2007 Otaka M, Yamamoto S, Ogasawara K, Takaoka Y, Noguchi S, Miyazaki T, Nakai A, Odashima M, Matsuhashi T, Watanabe S, Itoh H. The induction mechanism of the molecular chaperone HSP70 in the gastric mucosa by Geranylgeranylacetone (HSP-inducer). Biochemical and Biophysical Research Communications. 353: 399-404. PMID 17182004 DOI: 10.1016/J.Bbrc.2006.12.031  0.447
2007 Uchiyama T, Atsuta H, Utsugi T, Oguri M, Hasegawa A, Nakamura T, Nakai A, Nakata M, Maruyama I, Tomura H, Okajima F, Tomono S, Kawazu S, Nagai R, Kurabayashi M. HSF1 and constitutively active HSF1 improve vascular endothelial function (heat shock proteins improve vascular endothelial function). Atherosclerosis. 190: 321-9. PMID 16678833 DOI: 10.1016/J.Atherosclerosis.2006.03.037  0.485
2006 Kitamei H, Kitaichi N, Yoshida K, Nakai A, Fujimoto M, Kitamura M, Iwabuchi K, Miyazaki A, Namba K, Ohno S, Onoé K. Association of heat shock protein 70 induction and the amelioration of experimental autoimmune uveoretinitis in mice. Immunobiology. 212: 11-8. PMID 17270705 DOI: 10.1016/J.Imbio.2006.08.004  0.412
2006 Sakamoto M, Minamino T, Toko H, Kayama Y, Zou Y, Sano M, Takaki E, Aoyagi T, Tojo K, Tajima N, Nakai A, Aburatani H, Komuro I. Upregulation of heat shock transcription factor 1 plays a critical role in adaptive cardiac hypertrophy. Circulation Research. 99: 1411-8. PMID 17095722 DOI: 10.1161/01.Res.0000252345.80198.97  0.362
2006 Hayashida N, Inouye S, Fujimoto M, Tanaka Y, Izu H, Takaki E, Ichikawa H, Rho J, Nakai A. A novel HSF1-mediated death pathway that is suppressed by heat shock proteins. The Embo Journal. 25: 4773-83. PMID 17024176 DOI: 10.1038/Sj.Emboj.7601370  0.557
2006 Shinozaki F, Minami M, Chiba T, Suzuki M, Yoshimatsu K, Ichikawa Y, Terasawa K, Emori Y, Matsumoto K, Kurosaki T, Nakai A, Tanaka K, Minami Y. Depletion of hsp90beta induces multiple defects in B cell receptor signaling. The Journal of Biological Chemistry. 281: 16361-9. PMID 16617057 DOI: 10.1074/Jbc.M600891200  0.429
2006 Uchiyama T, Atsuta H, Utsugi T, Ohyama Y, Nakamura T, Nakai A, Nakata M, Maruyama I, Tomura H, Okajima F, Tomono S, Kawazu S, Nagai R, Kurarbayashi M. Simvastatin induces heat shock factor 1 in vascular endothelial cells. Atherosclerosis. 188: 265-73. PMID 16375908 DOI: 10.1016/J.Atherosclerosis.2005.10.045  0.472
2006 Hietakangas V, Anckar J, Blomster HA, Fujimoto M, Palvimo JJ, Nakai A, Sistonen L. PDSM, a motif for phosphorylation-dependent SUMO modification. Proceedings of the National Academy of Sciences of the United States of America. 103: 45-50. PMID 16371476 DOI: 10.1073/Pnas.0503698102  0.605
2006 Takaki E, Fujimoto M, Sugahara K, Nakahari T, Yonemura S, Tanaka Y, Hayashida N, Inouye S, Takemoto T, Yamashita H, Nakai A. Maintenance of olfactory neurogenesis requires HSF1, a major heat shock transcription factor in mice. The Journal of Biological Chemistry. 281: 4931-7. PMID 16306048 DOI: 10.1074/Jbc.M506911200  0.428
2005 Mikuriya T, Sugahara K, Takemoto T, Tanaka K, Takeno K, Shimogori H, Nakai A, Yamashita H. Geranylgeranylacetone, a heat shock protein inducer, prevents acoustic injury in the guinea pig. Brain Research. 1065: 107-14. PMID 16309629 DOI: 10.1016/J.Brainres.2005.10.045  0.401
2005 Fujimoto M, Takaki E, Hayashi T, Kitaura Y, Tanaka Y, Inouye S, Nakai A. Active HSF1 significantly suppresses polyglutamine aggregate formation in cellular and mouse models. The Journal of Biological Chemistry. 280: 34908-16. PMID 16051598 DOI: 10.1074/Jbc.M506288200  0.469
2004 Fujimoto M, Izu H, Seki K, Fukuda K, Nishida T, Yamada S, Kato K, Yonemura S, Inouye S, Nakai A. HSF4 is required for normal cell growth and differentiation during mouse lens development. The Embo Journal. 23: 4297-306. PMID 15483628 DOI: 10.1038/Sj.Emboj.7600435  0.484
2004 Katsuki K, Fujimoto M, Zhang XY, Izu H, Takaki E, Tanizawa Y, Inouye S, Nakai A. Feeding induces expression of heat shock proteins that reduce oxidative stress. Febs Letters. 571: 187-91. PMID 15280040 DOI: 10.1016/J.Febslet.2004.06.087  0.539
2004 Inouye S, Izu H, Takaki E, Suzuki H, Shirai M, Yokota Y, Ichikawa H, Fujimoto M, Nakai A. Impaired IgG production in mice deficient for heat shock transcription factor 1. The Journal of Biological Chemistry. 279: 38701-9. PMID 15226319 DOI: 10.1074/Jbc.M405986200  0.443
2004 Fujimoto M, Inouye S, Nakai A. [Physiological roles of heat shock transcription factors]. Seikagaku. the Journal of Japanese Biochemical Society. 76: 419-28. PMID 15212230  0.42
2004 Katoh Y, Fujimoto M, Nakamura K, Inouye S, Sugahara K, Izu H, Nakai A. Hsp25, a member of the Hsp30 family, promotes inclusion formation in response to stress. Febs Letters. 565: 28-32. PMID 15135047 DOI: 10.1016/J.Febslet.2003.12.085  0.482
2004 Izu H, Inouye S, Fujimoto M, Shiraishi K, Naito K, Nakai A. Heat shock transcription factor 1 is involved in quality-control mechanisms in male germ cells. Biology of Reproduction. 70: 18-24. PMID 12954729 DOI: 10.1095/Biolreprod.103.020065  0.528
2003 Zou Y, Zhu W, Sakamoto M, Qin Y, Akazawa H, Toko H, Mizukami M, Takeda N, Minamino T, Takano H, Nagai T, Nakai A, Komuro I. Heat shock transcription factor 1 protects cardiomyocytes from ischemia/reperfusion injury. Circulation. 108: 3024-30. PMID 14623809 DOI: 10.1161/01.Cir.0000101923.54751.77  0.369
2003 Sugahara K, Inouye S, Izu H, Katoh Y, Katsuki K, Takemoto T, Shimogori H, Yamashita H, Nakai A. Heat shock transcription factor HSF1 is required for survival of sensory hair cells against acoustic overexposure. Hearing Research. 182: 88-96. PMID 12948605 DOI: 10.1016/S0378-5955(03)00180-1  0.529
2003 Inouye S, Katsuki K, Izu H, Fujimoto M, Sugahara K, Yamada S, Shinkai Y, Oka Y, Katoh Y, Nakai A. Activation of heat shock genes is not necessary for protection by heat shock transcription factor 1 against cell death due to a single exposure to high temperatures. Molecular and Cellular Biology. 23: 5882-95. PMID 12897157 DOI: 10.1128/Mcb.23.16.5882-5895.2003  0.57
2003 Widłak W, Benedyk K, Vydra N, Głowala M, Scieglińska D, Małusecka E, Nakai A, Krawczyk Z. Expression of a constitutively active mutant of heat shock factor 1 under the control of testis-specific hst70 gene promoter in transgenic mice induces degeneration of seminiferous epithelium. Acta Biochimica Polonica. 50: 535-41. PMID 12833178 DOI: 10.18388/Abp.2003_3706  0.545
2002 Shallom JM, Di Carlo AL, Ko D, Penafiel LM, Nakai A, Litovitz TA. Microwave exposure induces Hsp70 and confers protection against hypoxia in chick embryos. Journal of Cellular Biochemistry. 86: 490-6. PMID 12210755 DOI: 10.1002/Jcb.10243  0.343
2002 Nishizawa J, Nakai A, Komeda M, Ban T, Nagata K. Increased preload directly induces the activation of heat shock transcription factor 1 in the left ventricular overloaded heart Cardiovascular Research. 55: 341-348. PMID 12123773 DOI: 10.1016/S0008-6363(02)00404-2  0.516
2001 Nakai A, Ishikawa T. Cell cycle transition under stress conditions controlled by vertebrate heat shock factors The Embo Journal. 20: 2885-2895. PMID 11387221 DOI: 10.1093/Emboj/20.11.2885  0.543
2000 Nakai A, Ishikawa T. A Nuclear Localization Signal Is Essential for Stress-induced Dimer-to-Trimer Transition of Heat Shock Transcription Factor 3 Journal of Biological Chemistry. 275: 34665-34671. PMID 10942768 DOI: 10.1074/Jbc.M005302200  0.484
2000 Tanikawa J, Ichikawa-Iwata E, Kanei-Ishii C, Nakai A, Matsuzawa SI, Reed JC, Ishii S. p53 Suppresses the c-Myb-induced activation of heat shock transcription factor 3 Journal of Biological Chemistry. 275: 15578-15585. PMID 10747903 DOI: 10.1074/Jbc.M000372200  0.478
2000 Nakai A, Suzuki M, Tanabe M. Arrest of spermatogenesis in mice expressing an active heat shock transcription factor 1 The Embo Journal. 19: 1545-1554. PMID 10747023 DOI: 10.1093/Emboj/19.7.1545  0.466
1999 Nakai A. New aspects in the vertebrate heat shock factor system: Hsf3 and Hsf4. Cell Stress & Chaperones. 4: 86-93. PMID 10547058 DOI: 10.1379/1466-1268(1999)004<0086:Naitvh>2.3.Co;2  0.453
1999 Kawazoe Y, Tanabe M, Sasai N, Nagata K, Nakai A. HSF3 is a major heat shock responsive factor duringchicken embryonic development. Febs Journal. 265: 688-697. PMID 10504401 DOI: 10.1046/J.1432-1327.1999.00762.X  0.543
1999 Tanabe M, Sasai N, Nagata K, Liu XD, Liu PCC, Thiele DJ, Nakai A. The mammalian HSF4 gene generates both an activator and a repressor of heat shock genes by alternative splicing Journal of Biological Chemistry. 274: 27845-27856. PMID 10488131 DOI: 10.1074/Jbc.274.39.27845  0.546
1999 Kawazoe Y, Tanabe M, Nakai A. Ubiquitous and cell-specific members of the avian small heat shock protein family. Febs Letters. 455: 271-275. PMID 10437787 DOI: 10.1016/S0014-5793(99)00900-X  0.53
1999 Nishizawa J, Nakai A, Matsuda K, Komeda M, Ban T, Nagata K. Reactive Oxygen Species Play an Important Role in the Activation of Heat Shock Factor 1 in Ischemic-Reperfused Heart Circulation. 99: 934-941. PMID 10027818 DOI: 10.1161/01.Cir.99.7.934  0.493
1998 Kawazoe Y, Nakai A, Tanabe M, Nagata K. Proteasome inhibition leads to the activation of all members of the heat-shock-factor family. Febs Journal. 255: 356-362. PMID 9716376 DOI: 10.1046/J.1432-1327.1998.2550356.X  0.533
1998 Tanabe M, Kawazoe Y, Takeda S, Morimoto RI, Nagata K, Nakai A. Disruption of the HSF3 gene results in the severe reduction of heat shock gene expression and loss of thermotolerance. The Embo Journal. 17: 1750-8. PMID 9501096 DOI: 10.1093/Emboj/17.6.1750  0.692
1997 Watanabe N, Tsuji N, Akiyama S, Sasaki H, Okamoto T, Kobayashi D, Sato T, Hagino T, Yamauchi N, Niitsu Y, Nakai A, Nagata K. Induction of heat shock protein 72 synthesis by endogenous tumor necrosis factor via enhancement of the heat shock element-binding activity of heat shock factor 1 European Journal of Immunology. 27: 2830-2834. PMID 9394806 DOI: 10.1002/Eji.1830271113  0.559
1997 Kanei-Ishii C, Tanikawa J, Nakai A, Morimoto RI, Ishii S. Activation of heat shock transcription factor 3 by c-Myb in the absence of cellular stress. Science (New York, N.Y.). 277: 246-8. PMID 9211854 DOI: 10.1126/Science.277.5323.246  0.622
1997 Tanabe M, Nakai A, Kawazoe Y, Nagata K. Different Thresholds in the Responses of Two Heat Shock Transcription Factors, HSF1 and HSF3 Journal of Biological Chemistry. 272: 15389-15395. PMID 9182569 DOI: 10.1074/Jbc.272.24.15389  0.549
1997 Nakai A, Tanabe M, Kawazoe Y, Inazawa J, Morimoto RI, Nagata K. HSF4, a new member of the human heat shock factor family which lacks properties of a transcriptional activator. Molecular and Cellular Biology. 17: 469-81. PMID 8972228 DOI: 10.1128/Mcb.17.1.469  0.671
1996 Nishizawa J, Nakai A, Higashi T, Tanabe M, Nomoto S, Matsuda K, Ban T, Nagata K. Reperfusion Causes Significant Activation of Heat Shock Transcription Factor 1 in Ischemic Rat Heart Circulation. 94: 2185-2192. PMID 8901670 DOI: 10.1161/01.Cir.94.9.2185  0.549
1996 Higashi T, Nakai A, Uemura Y, Kikuchi H, Nagata K. Activation of heat shock factor 1 in rat brain during cerebral ischemia or after heat shock. Brain Research. Molecular Brain Research. 34: 262-70. PMID 8750829 DOI: 10.1016/0169-328X(95)00163-M  0.531
1995 Higashi T, Nishi S, Nakai A, Nagata K. Regulatory mechanism of stress response in mammalian nervous system during cerebral ischaemia or after heat shock. Neuropathology and Applied Neurobiology. 21: 480-483. PMID 8745234 DOI: 10.1111/J.1365-2990.1995.Tb01091.X  0.467
1995 Yasuda K, Nakai A, Hatayama T, Nagata K. Cloning and Expression of Murine High Molecular Mass Heat Shock Proteins, HSP105 Journal of Biological Chemistry. 270: 29718-29723. PMID 8530361 DOI: 10.1074/Jbc.270.50.29718  0.51
1995 Nakai A, Kawatani T, Ohi S, Kawasaki H, Yoshimori T, Tashiro Y, Miyata Y, Yahara I, Satoh M, Nagata K. Expression and phosphorylation of BiP/GRP78, a molecular chaperone in the endoplasmic reticulum, during the differentiation of a mouse myeloblastic cell line. Cell Structure and Function. 20: 33-9. PMID 7796466 DOI: 10.1247/Csf.20.33  0.343
1995 Nagai N, Nakai A, Nagata K. Quercetin suppresses heat shock response by down regulation of HSF1. Biochemical and Biophysical Research Communications. 208: 1099-1105. PMID 7702609 DOI: 10.1006/Bbrc.1995.1447  0.546
1995 Nakai A, Kawazoe Y, Tanabe M, Nagata K, Morimoto RI. The DNA-binding properties of two heat shock factors, HSF1 and HSF3, are induced in the avian erythroblast cell line HD6. Molecular and Cellular Biology. 15: 5268-78. PMID 7565675 DOI: 10.1128/Mcb.15.10.5268  0.65
1995 Davids JW, Elthaher TSH, Nakai A, Nagata K, Miller AD. Modeling the Three-Dimensional Structure of Serpin/Molecular Chaperone HSP47 Bioorganic Chemistry. 23: 427-438. DOI: 10.1006/Bioo.1995.1029  0.381
1994 Morimoto RI, Jurivich DA, Kroeger PE, Mathur SK, Murphy SP, Nakai A, Sarge K, Abravaya K, Sistonen LT. 17 Regulation of Heat Shock Gene Transcription by a Family of Heat Shock Factors Cold Spring Harbor Monograph Archive. 26: 417-455. DOI: 10.1101/087969427.26.417  0.769
1994 Higashi T, Nakai A, Uemura Y, Kikuchi H, Nagata K. Activation of heat shock factor 1 following focal cerebral ischemia in rats Pathophysiology. 1: 139. DOI: 10.1016/0928-4680(94)90295-X  0.316
1994 Nagata K, Nakai A. Expression and function of stress (Heat shock) proteins: Pathophysiological significance of HSP47, a collagen-specific molecular chaperone Pathophysiology. 1: 137. DOI: 10.1016/0928-4680(94)90291-7  0.434
1993 Nakai A, Morimoto RI. Characterization of a novel chicken heat shock transcription factor, heat shock factor 3, suggests a new regulatory pathway. Molecular and Cellular Biology. 13: 1983-97. PMID 8455593 DOI: 10.1128/mcb.13.4.1983-1997.1993  0.64
1993 Satoh M, Nakai A, Sokawa Y, Hirayoshi K, Nagata K. Modulation of the phosphorylation of glucose-regulated protein, GRP78, by transformation and inhibition of glycosylation. Experimental Cell Research. 205: 76-83. PMID 8454000 DOI: 10.1006/Excr.1993.1060  0.334
1992 Nakai A, Satoh M, Hirayoshi K, Nagata K. Involvement of the stress protein HSP47 in procollagen processing in the endoplasmic reticulum. The Journal of Cell Biology. 117: 903-14. PMID 1577863 DOI: 10.1083/Jcb.117.4.903  0.47
1992 Koishi M, Hosokawa N, Sato M, Nakai A, Hirayoshi K, Hiraoka M, Abe M, Nagata K. Quercetin, an inhibitor of heat shock protein synthesis, inhibits the acquisition of thermotolerance in a human colon carcinoma cell line. Japanese Journal of Cancer Research. 83: 1216-1222. PMID 1483935 DOI: 10.1111/J.1349-7006.1992.Tb02748.X  0.475
1992 Takechi H, Hirayoshi K, Nakai A, Kudo H, Saga S, Nagata K. Molecular cloning of a mouse 47-kDa heat-shock protein (HSP47), a collagen-binding stress protein, and its expression during the differentiation of F9 teratocarcinoma cells. Febs Journal. 206: 323-329. PMID 1317794 DOI: 10.1111/J.1432-1033.1992.Tb16930.X  0.504
1991 Hirayoshi K, Kudo H, Takechi H, Nakai A, Iwamatsu A, Yamada KM, Nagata K. HSP47: a tissue-specific, transformation-sensitive, collagen-binding heat shock protein of chicken embryo fibroblasts. Molecular and Cellular Biology. 11: 4036-44. PMID 2072906 DOI: 10.1128/Mcb.11.8.4036  0.486
1991 Nakai A, Satoh M, Hirayoshi K, Nagata K. Identification of the ATP-binding heat-inducible protein of MR = 37,000 as glyceraldehyde-3-phosphate dehydrogenase. Biochemical and Biophysical Research Communications. 176: 59-64. PMID 2018545 DOI: 10.1016/0006-291X(91)90889-F  0.446
1990 Ohtsuka K, Masuda A, Nakai A, Nagata K. A novel 40-kDa protein induced by heat shock and other stresses in mammalian and avian cells Biochemical and Biophysical Research Communications. 166: 642-647. PMID 2302229 DOI: 10.1016/0006-291X(90)90857-J  0.525
1990 Nakai A, Hirayama C, Ohtsuka K, Hirayoshi K, Nagata K. Novel ATP-binding heat-inducible protein of Mr = 37,000 that is sensitive to transformation in BALB/3T3 cells Journal of Cellular Physiology. 143: 577-589. PMID 2113536 DOI: 10.1002/Jcp.1041430324  0.479
1990 Hosokawa N, Hirayoshi K, Nakai A, Hosokawa Y, Marui N, Yoshida M, Sakai T, Nishino H, Aoike A, Kawai K, Nagata K. Flavonoids inhibit the expression of heat shock proteins Cell Structure and Function. 15: 393-401. PMID 2085852 DOI: 10.1247/Csf.15.393  0.556
1990 Nakai A, Hirayoshi K, Nagata K. Transformation of BALB/3T3 cells by simian virus 40 causes a decreased synthesis of a collagen-binding heat-shock protein (hsp47). Journal of Biological Chemistry. 265: 992-999. DOI: 10.1016/s0021-9258(19)40148-8  0.365
1989 Nakai A, Hirayoshi K, Saga S, Yamada KM, Nagata K. The transformation-sensitive heat shock protein (hsp47) binds specifically to Fetuin. Biochemical and Biophysical Research Communications. 164: 259-64. PMID 2478127 DOI: 10.1016/0006-291X(89)91711-7  0.457
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