| Year |
Citation |
Score |
| 2024 |
Gebru NT, Guergues J, Verdina LA, Wohlfahrt J, Wang S, Armendariz DS, Gray M, Beaulieu-Abdelahad D, Stevens SM, Gulick D, Blair LJ. Fkbp5 gene deletion: Circadian rhythm profile and brain proteomics in aged mice. Aging Cell. e14314. PMID 39225086 DOI: 10.1111/acel.14314 |
0.304 |
|
| 2023 |
Esquivel AR, Hill SE, Blair LJ. DnaJs are enriched in tau regulators. International Journal of Biological Macromolecules. 253: 127486. PMID 37852393 DOI: 10.1016/j.ijbiomac.2023.127486 |
0.456 |
|
| 2023 |
Hill SE, Beaulieu-Abdelahad D, Lemus A, Webster JM, Ospina SR, Darling AL, Martin MD, Patel S, Bridenstine L, Swonger R, Paul S, Blackburn R, Calcul L, Dickey CA, Leahy JW, ... Blair LJ, et al. . Acs Chemical Biology. PMID 37144894 DOI: 10.1021/acschembio.2c00919 |
0.801 |
|
| 2023 |
Jiang L, Chakraborty P, Zhang L, Wong M, Hill SE, Webber CJ, Libera J, Blair LJ, Wolozin B, Zweckstetter M. Chaperoning of specific tau structure by immunophilin FKBP12 regulates the neuronal resilience to extracellular stress. Science Advances. 9: eadd9789. PMID 36724228 DOI: 10.1126/sciadv.add9789 |
0.447 |
|
| 2022 |
Zhu Y, Gandy L, Zhang F, Liu J, Wang C, Blair LJ, Linhardt RJ, Wang L. Heparan Sulfate Proteoglycans in Tauopathy. Biomolecules. 12. PMID 36551220 DOI: 10.3390/biom12121792 |
0.437 |
|
| 2022 |
Hill SE, Esquivel AR, Ospina SR, Rahal LM, Dickey CA, Blair LJ. Chaperoning activity of the cyclophilin family prevents tau aggregation. Protein Science : a Publication of the Protein Society. 31: e4448. PMID 36305768 DOI: 10.1002/pro.4448 |
0.788 |
|
| 2022 |
Criado-Marrero M, Blazier DM, Gould LA, Gebru NT, Rodriguez Ospina S, Armendariz DS, Darling AL, Beaulieu-Abdelahad D, Blair LJ. Evidence against a contribution of the CCAAT-enhancer binding protein homologous protein (CHOP) in mediating neurotoxicity in rTg4510 mice. Scientific Reports. 12: 7372. PMID 35513476 DOI: 10.1038/s41598-022-11025-x |
0.401 |
|
| 2022 |
Rodriguez Ospina S, Blazier DM, Criado-Marrero M, Gould LA, Gebru NT, Beaulieu-Abdelahad D, Wang X, Remily-Wood E, Chaput D, Stevens S, Uversky VN, Bickford PC, Dickey CA, Blair LJ. Small Heat Shock Protein 22 Improves Cognition and Learning in the Tauopathic Brain. International Journal of Molecular Sciences. 23. PMID 35055033 DOI: 10.3390/ijms23020851 |
0.791 |
|
| 2021 |
Criado-Marrero M, Gebru NT, Blazier DM, Gould LA, Baker JD, Beaulieu-Abdelahad D, Blair LJ. Correction to: Hsp90 co‑chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild‑type mice. Acta Neuropathologica Communications. 9: 85. PMID 33975631 DOI: 10.1186/s40478-021-01188-5 |
0.32 |
|
| 2021 |
Criado-Marrero M, Gebru NT, Gould LA, Blazier DM, Vidal-Aguiar Y, Smith TM, Abdelmaboud SS, Shelton LB, Wang X, Dahrendorff J, Beaulieu-Abdelahad D, Dickey CA, Blair LJ. FKBP52 overexpression accelerates hippocampal-dependent memory impairments in a tau transgenic mouse model. Npj Aging and Mechanisms of Disease. 7: 9. PMID 33941782 DOI: 10.1038/s41514-021-00062-x |
0.751 |
|
| 2021 |
Criado-Marrero M, Gebru NT, Blazier DM, Gould LA, Baker JD, Beaulieu-Abdelahad D, Blair LJ. Hsp90 co-chaperones, FKBP52 and Aha1, promote tau pathogenesis in aged wild-type mice. Acta Neuropathologica Communications. 9: 65. PMID 33832539 DOI: 10.1186/s40478-021-01159-w |
0.508 |
|
| 2021 |
Darling AL, Dahrendorff J, Creodore SG, Dickey CA, Blair LJ, Uversky VN. Small heat shock protein 22kDa can modulate the aggregation and liquid-liquid phase separation behavior of Tau. Protein Science : a Publication of the Protein Society. PMID 33686711 DOI: 10.1002/pro.4060 |
0.768 |
|
| 2021 |
Sandusky-Beltran LA, Kovalenko A, Placides DS, Ratnasamy K, Ma C, Hunt JB, Liang H, Calahatian JIT, Michalski C, Fahnestock M, Blair LJ, Darling AL, Baker JD, Fontaine SN, Dickey CA, et al. Aberrant AZIN2 and polyamine metabolism precipitates tau neuropathology. The Journal of Clinical Investigation. 131. PMID 33586680 DOI: 10.1172/JCI126299 |
0.752 |
|
| 2020 |
Criado-Marrero M, Smith TM, Gould LA, Kim S, Penny HJ, Sun Z, Gulick D, Dickey CA, Blair LJ. FKBP5 and early life stress affect the hippocampus by an age-dependent mechanism. Brain, Behavior, & Immunity - Health. 9: 100143. PMID 34589890 DOI: 10.1016/j.bbih.2020.100143 |
0.68 |
|
| 2020 |
Webster JM, Darling AL, Sanders TA, Blazier DM, Vidal-Aguiar Y, Beaulieu-Abdelahad D, Plemmons DG, Hill SE, Uversky VN, Bickford PC, Dickey CA, Blair LJ. Hsp22 with an N-Terminal Domain Truncation Mediates a Reduction in Tau Protein Levels. International Journal of Molecular Sciences. 21. PMID 32751642 DOI: 10.3390/Ijms21155442 |
0.791 |
|
| 2020 |
Singh JK, Hutt DM, Tait B, Guy NC, Sivils JC, Ortiz NR, Payan AN, Komaragiri SK, Owens JJ, Culbertson D, Blair LJ, Dickey C, Kuo SY, Finley D, Dyson HJ, et al. Management of Hsp90-Dependent Protein Folding by Small Molecules Targeting the Aha1 Co-Chaperone. Cell Chemical Biology. PMID 32017918 DOI: 10.1016/J.Chembiol.2020.01.008 |
0.734 |
|
| 2019 |
Gracia L, Lora G, Blair LJ, Jinwal UK. Therapeutic Potential of the Hsp90/Cdc37 Interaction in Neurodegenerative Diseases. Frontiers in Neuroscience. 13: 1263. PMID 31824256 DOI: 10.3389/fnins.2019.01263 |
0.411 |
|
| 2019 |
Webster JM, Darling AL, Uversky VN, Blair LJ. Small Heat Shock Proteins, Big Impact on Protein Aggregation in Neurodegenerative Disease. Frontiers in Pharmacology. 10: 1047. PMID 31619995 DOI: 10.3389/Fphar.2019.01047 |
0.412 |
|
| 2019 |
Sandusky-Beltran LA, Kovalenko A, Ma C, Calahatian JIT, Placides DS, Watler MD, Hunt JB, Darling AL, Baker JD, Blair LJ, Martin MD, Fontaine SN, Dickey CA, Lussier AL, Weeber EJ, et al. Spermidine/spermine-N-acetyltransferase ablation impacts tauopathy-induced polyamine stress response. Alzheimer's Research & Therapy. 11: 58. PMID 31253191 DOI: 10.1186/S13195-019-0507-Y |
0.796 |
|
| 2019 |
Criado-Marrero M, Gebru NT, Gould LA, Smith TM, Kim S, Blackburn RJ, Dickey CA, Blair LJ. Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus. International Journal of Molecular Sciences. 20. PMID 31167373 DOI: 10.3390/ijms20112738 |
0.695 |
|
| 2019 |
Blair LJ, Criado-Marrero M, Zheng D, Wang X, Kamath S, Nordhues BA, Weeber EJ, Dickey CA. The Disease-Associated Chaperone FKBP51 Impairs Cognitive Function by Accelerating AMPA Receptor Recycling. Eneuro. 6. PMID 30963102 DOI: 10.1523/ENEURO.0242-18.2019 |
0.697 |
|
| 2019 |
Darling AL, Breydo L, Rivas EG, Gebru NT, Zheng D, Baker JD, Blair LJ, Dickey CA, Koren J, Uversky VN. Repeated repeat problems: Combinatorial effect of C9orf72-derived dipeptide repeat proteins. International Journal of Biological Macromolecules. PMID 30639592 DOI: 10.1016/J.Ijbiomac.2019.01.035 |
0.753 |
|
| 2018 |
Oroz J, Chang BJ, Wysoczanski P, Lee CT, Pérez-Lara Á, Chakraborty P, Hofele RV, Baker JD, Blair LJ, Biernat J, Urlaub H, Mandelkow E, Dickey CA, Zweckstetter M. Structure and pro-toxic mechanism of the human Hsp90/PPIase/Tau complex. Nature Communications. 9: 4532. PMID 30382094 DOI: 10.1038/s41467-018-06880-0 |
0.757 |
|
| 2018 |
Sabbagh JJ, Cordova RA, Zheng D, Criado-Marrero M, Lemus A, Li P, Baker JD, Nordhues BA, Darling AL, Martinez-Licha C, Rutz DA, Patel S, Buchner J, Leahy JW, Koren J, ... ... Blair LJ, et al. Targeting the FKBP51/GR/Hsp90 complex to identify functionally relevant treatments for depression and PTSD. Acs Chemical Biology. PMID 29893552 DOI: 10.1021/Acschembio.8B00454 |
0.78 |
|
| 2018 |
Huard DJ, Crowley VM, Du Y, Cordova RA, Sun Z, Tomlin MO, Dickey CA, Koren J, Blair L, Fu H, Blagg BSJ, Lieberman RL. Trifunctional high-throughput screen identifies promising scaffold to inhibit Grp94 and treat myocilin-associated glaucoma. Acs Chemical Biology. PMID 29402077 DOI: 10.1021/Acschembio.7B01083 |
0.78 |
|
| 2018 |
Criado-Marrero M, Rein T, Binder EB, Porter JT, Koren J, Blair LJ. Hsp90 and FKBP51: complex regulators of psychiatric diseases. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 373. PMID 29203717 DOI: 10.1098/Rstb.2016.0532 |
0.643 |
|
| 2017 |
Shelton LB, Koren J, Blair LJ. Imbalances in the Hsp90 Chaperone Machinery: Implications for Tauopathies. Frontiers in Neuroscience. 11: 724. PMID 29311797 DOI: 10.3389/Fnins.2017.00724 |
0.752 |
|
| 2017 |
Stothert AR, Suntharalingam A, Tang X, Crowley VM, Mishra SJ, Webster JM, Nordhues BA, Huard DJE, Passaglia CL, Lieberman RL, Blagg BSJ, Blair LJ, Koren J, Dickey CA. Isoform-selective Hsp90 inhibition rescues model of hereditary open-angle glaucoma. Scientific Reports. 7: 17951. PMID 29263415 DOI: 10.1038/S41598-017-18344-4 |
0.792 |
|
| 2017 |
Shelton LB, Baker JD, Zheng D, Sullivan LE, Solanki PK, Webster JM, Sun Z, Sabbagh JJ, Nordhues BA, Koren J, Ghosh S, Blagg BSJ, Blair LJ, Dickey CA. Hsp90 activator Aha1 drives production of pathological tau aggregates. Proceedings of the National Academy of Sciences of the United States of America. PMID 28827321 DOI: 10.1073/Pnas.1707039114 |
0.846 |
|
| 2017 |
Baker JD, Shelton LB, Zheng D, Favretto F, Nordhues BA, Darling A, Sullivan LE, Sun Z, Solanki PK, Martin MD, Suntharalingam A, Sabbagh JJ, Becker S, Mandelkow E, Uversky VN, ... ... Blair LJ, et al. Human cyclophilin 40 unravels neurotoxic amyloids. Plos Biology. 15: e2001336. PMID 28654636 DOI: 10.1371/Journal.Pbio.2001336 |
0.828 |
|
| 2016 |
Zheng D, Sabbagh JJ, Blair LJ, Darling AL, Wen X, Dickey CA. MicroRNA-511 binds to FKBP5 mRNA, which encodes a chaperone protein, and regulates neuronal differentiation. The Journal of Biological Chemistry. PMID 27334923 DOI: 10.1074/Jbc.M116.727941 |
0.668 |
|
| 2016 |
Fontaine SN, Zheng D, Sabbagh JJ, Martin MD, Chaput D, Darling A, Trotter JH, Stothert AR, Nordhues BA, Lussier A, Baker J, Shelton L, Kahn M, Blair LJ, Stevens SM, et al. DnaJ/Hsc70 chaperone complexes control the extracellular release of neurodegenerative-associated proteins. The Embo Journal. PMID 27261198 DOI: 10.15252/Embj.201593489 |
0.762 |
|
| 2016 |
Sabbagh JJ, Fontaine SN, Shelton LB, Blair LJ, Hunt JB, Zhang B, Lee DC, Lloyd JD, Dickey CA. Non-contact rotational head injury produces transient cognitive deficits but lasting neuropathological changes. Journal of Neurotrauma. PMID 26739819 DOI: 10.1089/neu.2015.4288 |
0.647 |
|
| 2015 |
Blair LJ, Frauen HD, Zhang B, Nordhues BA, Bijan S, Lin YC, Zamudio F, Hernandez LD, Sabbagh JJ, Selenica ML, Dickey CA. Tau depletion prevents progressive blood-brain barrier damage in a mouse model of tauopathy. Acta Neuropathologica Communications. 3: 8. PMID 25775028 DOI: 10.1186/s40478-015-0186-2 |
0.732 |
|
| 2015 |
Blair LJ, Baker JD, Sabbagh JJ, Dickey CA. The emerging role of peptidyl-prolyl isomerase chaperones in tau oligomerization, amyloid processing, and Alzheimer's disease. Journal of Neurochemistry. 133: 1-13. PMID 25628064 DOI: 10.1111/jnc.13033 |
0.789 |
|
| 2014 |
Sabbagh JJ, O'Leary JC, Blair LJ, Klengel T, Nordhues BA, Fontaine SN, Binder EB, Dickey CA. Age-associated epigenetic upregulation of the FKBP5 gene selectively impairs stress resiliency. Plos One. 9: e107241. PMID 25191701 DOI: 10.1371/journal.pone.0107241 |
0.685 |
|
| 2014 |
Selenica ML, Davtyan H, Housley SB, Blair LJ, Gillies A, Nordhues BA, Zhang B, Liu J, Gestwicki JE, Lee DC, Gordon MN, Morgan D, Dickey CA. Epitope analysis following active immunization with tau proteins reveals immunogens implicated in tau pathogenesis. Journal of Neuroinflammation. 11: 152. PMID 25183004 DOI: 10.1186/S12974-014-0152-0 |
0.792 |
|
| 2014 |
Blair LJ, Sabbagh JJ, Dickey CA. Targeting Hsp90 and its co-chaperones to treat Alzheimer's disease. Expert Opinion On Therapeutic Targets. 18: 1219-32. PMID 25069659 DOI: 10.1517/14728222.2014.943185 |
0.781 |
|
| 2013 |
Blair LJ, Zhang B, Dickey CA. Potential synergy between tau aggregation inhibitors and tau chaperone modulators. Alzheimer's Research & Therapy. 5: 41. PMID 24041111 DOI: 10.1186/alzrt207 |
0.793 |
|
| 2013 |
O'Leary JC, Zhang B, Koren J, Blair L, Dickey CA. The role of FKBP5 in mood disorders: action of FKBP5 on steroid hormone receptors leads to questions about its evolutionary importance. Cns & Neurological Disorders Drug Targets. 12: 1157-62. PMID 24040820 DOI: 10.2174/187152731131200121 |
0.746 |
|
| 2013 |
Blair LJ, Nordhues BA, Hill SE, Scaglione KM, O'Leary JC, Fontaine SN, Breydo L, Zhang B, Li P, Wang L, Cotman C, Paulson HL, Muschol M, Uversky VN, Klengel T, et al. Accelerated neurodegeneration through chaperone-mediated oligomerization of tau. The Journal of Clinical Investigation. 123: 4158-69. PMID 23999428 DOI: 10.1172/Jci69003 |
0.797 |
|
| 2013 |
Abisambra JF, Jinwal UK, Blair LJ, O'Leary JC, Li Q, Brady S, Wang L, Guidi CE, Zhang B, Nordhues BA, Cockman M, Suntharalingham A, Li P, Jin Y, Atkins CA, et al. Tau accumulation activates the unfolded protein response by impairing endoplasmic reticulum-associated degradation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 9498-507. PMID 23719816 DOI: 10.1523/Jneurosci.5397-12.2013 |
0.842 |
|
| 2013 |
Abisambra J, Jinwal UK, Miyata Y, Rogers J, Blair L, Li X, Seguin SP, Wang L, Jin Y, Bacon J, Brady S, Cockman M, Guidi C, Zhang J, Koren J, et al. Allosteric heat shock protein 70 inhibitors rapidly rescue synaptic plasticity deficits by reducing aberrant tau. Biological Psychiatry. 74: 367-74. PMID 23607970 DOI: 10.1016/J.Biopsych.2013.02.027 |
0.834 |
|
| 2013 |
Jinwal UK, Akoury E, Abisambra JF, O'Leary JC, Thompson AD, Blair LJ, Jin Y, Bacon J, Nordhues BA, Cockman M, Zhang J, Li P, Zhang B, Borysov S, Uversky VN, et al. Imbalance of Hsp70 family variants fosters tau accumulation. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 27: 1450-9. PMID 23271055 DOI: 10.1096/Fj.12-220889 |
0.843 |
|
| 2012 |
Suntharalingam A, Abisambra JF, O'Leary JC, Koren J, Zhang B, Joe MK, Blair LJ, Hill SE, Jinwal UK, Cockman M, Duerfeldt AS, Tomarev S, Blagg BS, Lieberman RL, Dickey CA. Glucose-regulated protein 94 triage of mutant myocilin through endoplasmic reticulum-associated degradation subverts a more efficient autophagic clearance mechanism. The Journal of Biological Chemistry. 287: 40661-9. PMID 23035116 DOI: 10.1074/Jbc.M112.384800 |
0.793 |
|
| 2012 |
Koren J, Miyata Y, Kiray J, O'Leary JC, Nguyen L, Guo J, Blair LJ, Li X, Li X, Jinwal UK, Cheng JQ, Gestwicki JE, Dickey CA. Rhodacyanine derivative selectively targets cancer cells and overcomes tamoxifen resistance. Plos One. 7: e35566. PMID 22563386 DOI: 10.1371/Journal.Pone.0035566 |
0.734 |
|
| 2011 |
Abisambra JF, Jinwal UK, Jones JR, Blair LJ, Koren J, Dickey CA. Exploiting the diversity of the heat-shock protein family for primary and secondary tauopathy therapeutics. Current Neuropharmacology. 9: 623-31. PMID 22654720 DOI: 10.2174/157015911798376226 |
0.836 |
|
| 2011 |
O'Leary JC, Dharia S, Blair LJ, Brady S, Johnson AG, Peters M, Cheung-Flynn J, Cox MB, de Erausquin G, Weeber EJ, Jinwal UK, Dickey CA. A new anti-depressive strategy for the elderly: ablation of FKBP5/FKBP51. Plos One. 6: e24840. PMID 21935478 DOI: 10.1371/journal.pone.0024840 |
0.679 |
|
| 2011 |
Jones JR, Lebar MD, Jinwal UK, Abisambra JF, Koren J, Blair L, O'Leary JC, Davey Z, Trotter J, Johnson AG, Weeber E, Eckman CB, Baker BJ, Dickey CA. The diarylheptanoid (+)-aR,11S-myricanol and two flavones from bayberry (Myrica cerifera) destabilize the microtubule-associated protein tau. Journal of Natural Products. 74: 38-44. PMID 21141876 DOI: 10.1021/Np100572Z |
0.831 |
|
| 2010 |
Abisambra JF, Blair LJ, Hill SE, Jones JR, Kraft C, Rogers J, Koren J, Jinwal UK, Lawson L, Johnson AG, Wilcock D, O'Leary JC, Jansen-West K, Muschol M, Golde TE, et al. Phosphorylation dynamics regulate Hsp27-mediated rescue of neuronal plasticity deficits in tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 15374-82. PMID 21084594 DOI: 10.1523/Jneurosci.3155-10.2010 |
0.838 |
|
| 2010 |
O'Leary JC, Li Q, Marinec P, Blair LJ, Congdon EE, Johnson AG, Jinwal UK, Koren J, Jones JR, Kraft C, Peters M, Abisambra JF, Duff KE, Weeber EJ, Gestwicki JE, et al. Phenothiazine-mediated rescue of cognition in tau transgenic mice requires neuroprotection and reduced soluble tau burden. Molecular Neurodegeneration. 5: 45. PMID 21040568 DOI: 10.1186/1750-1326-5-45 |
0.821 |
|
| 2010 |
Lee DC, Rizer J, Selenica ML, Reid P, Kraft C, Johnson A, Blair L, Gordon MN, Dickey CA, Morgan D. LPS- induced inflammation exacerbates phospho-tau pathology in rTg4510 mice. Journal of Neuroinflammation. 7: 56. PMID 20846376 DOI: 10.1186/1742-2094-7-56 |
0.776 |
|
| 2010 |
Jinwal UK, O'Leary JC, Borysov SI, Jones JR, Li Q, Koren J, Abisambra JF, Vestal GD, Lawson LY, Johnson AG, Blair LJ, Jin Y, Miyata Y, Gestwicki JE, Dickey CA. Hsc70 rapidly engages tau after microtubule destabilization. The Journal of Biological Chemistry. 285: 16798-805. PMID 20308058 DOI: 10.1074/Jbc.M110.113753 |
0.832 |
|
| 2010 |
Jinwal UK, Koren J, Borysov SI, Schmid AB, Abisambra JF, Blair LJ, Johnson AG, Jones JR, Shults CL, O'Leary JC, Jin Y, Buchner J, Cox MB, Dickey CA. The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 591-9. PMID 20071522 DOI: 10.1523/Jneurosci.4815-09.2010 |
0.845 |
|
| 2010 |
Koren J, Jinwal UK, Jin Y, O'Leary J, Jones JR, Johnson AG, Blair LJ, Abisambra JF, Chang L, Miyata Y, Cheng AM, Guo J, Cheng JQ, Gestwicki JE, Dickey CA. Facilitating Akt clearance via manipulation of Hsp70 activity and levels. The Journal of Biological Chemistry. 285: 2498-505. PMID 19889640 DOI: 10.1074/Jbc.M109.057208 |
0.794 |
|
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