Philip Biggin - Publications

2011- Biochemistry University of Oxford, Oxford, United Kingdom 

98 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Busch JMC, Matsoukas MT, Musgaard M, Spyroulias GA, Biggin PC, Vakonakis I. Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerisation. The Journal of Biological Chemistry. PMID 32873708 DOI: 10.1074/jbc.RA120.014780  0.76
2019 Stenum-Berg C, Musgaard M, Chavez-Abiega S, Thisted CL, Barrella L, Biggin PC, Kristensen AS. Mutational analysis and modeling of negative allosteric modulator binding sites in AMPA receptors. Molecular Pharmacology. PMID 31582576 DOI: 10.1124/mol.119.116871  0.76
2019 Busch JMC, Erat MC, Blank ID, Musgaard M, Biggin PC, Vakonakis I. A dynamically interacting flexible loop assists oligomerisation of the Caenorhabditis elegans centriolar protein SAS-6. Scientific Reports. 9: 3526. PMID 30837637 DOI: 10.1038/s41598-019-40294-2  0.76
2018 Finelli MJ, Paramo T, Pires E, Ryan BJ, Wade-Martins R, Biggin PC, McCullagh J, Oliver PL. Oxidation Resistance 1 Modulates Glycolytic Pathways in the Cerebellum via an Interaction with Glucose-6-Phosphate Isomerase. Molecular Neurobiology. PMID 29905912 DOI: 10.1007/s12035-018-1174-x  0.52
2017 Chu Y, Tu T, Penttinen L, Xue X, Wang X, Yi Z, Gong L, Rouvinen J, Luo H, Hakulinen N, Yao B, Su X. Insights into the roles of non-catalytic residues in the active site of a GH10 xylanase with activity on cellulose. The Journal of Biological Chemistry. PMID 28974575 DOI: 10.1074/jbc.M117.807768  0.32
2017 Paramo T, Brown PMGE, Musgaard M, Bowie D, Biggin PC. Functional Validation of Heteromeric Kainate Receptor Models. Biophysical Journal. PMID 28935133 DOI: 10.1016/j.bpj.2017.08.047  0.76
2017 Musgaard M, Paramo T, Domicevica L, Andersen OJ, Biggin PC. Insights into channel dysfunction from modelling and molecular dynamics simulations. Neuropharmacology. PMID 28669899 DOI: 10.1016/j.neuropharm.2017.06.030  0.76
2017 Safar F, Hurdiss E, Erotocritou M, Greiner T, Lape R, Irvine MW, Fang G, Jane D, Yu R, Dämgen MA, Biggin PC, Sivilotti LG. The startle disease mutation E103K impairs activation of human homomeric α1 glycine receptors by disrupting an intersubunit salt bridge across the agonist binding site. The Journal of Biological Chemistry. PMID 28174298 DOI: 10.1074/jbc.M116.767616  0.4
2016 Alcaino C, Musgaard M, Minguez T, Mazzaferro S, Faundez M, Iturriaga-Vasquez P, Biggin PC, Bermudez I. Role of the Cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. PMID 27864368 DOI: 10.1074/jbc.M116.751206  0.76
2016 Musgaard M, Biggin PC. Steered Molecular Dynamics Simulations Predict Conformational Stability of Glutamate Receptors. Journal of Chemical Information and Modeling. PMID 27482759 DOI: 10.1021/acs.jcim.6b00297  0.76
2016 Sridhar A, Johnston AJ, Varathan L, McLain SE, Biggin PC. The solvation structure of alprazolam. Physical Chemistry Chemical Physics : Pccp. PMID 27465367 DOI: 10.1039/c6cp02645a  0.76
2016 Dawe GB, Musgaard M, Aurousseau MR, Nayeem N, Green T, Biggin PC, Bowie D. Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes. Neuron. PMID 26924438 DOI: 10.1016/j.neuron.2016.01.038  0.76
2016 Aldeghi M, Heifetz A, Bodkin MJ, Knapp S, Biggin PC. Accurate calculation of the absolute free energy of binding for drug molecules. Chemical Science (Royal Society of Chemistry : 2010). 7: 207-218. PMID 26798447 DOI: 10.1039/c5sc02678d  0.76
2016 Braun N, Lynagh T, Yu R, Biggin PC, Pless SA. The role of an absolutely conserved tryptophan pair in the extracellular domain of Cys-loop receptors. Acs Chemical Neuroscience. PMID 26764897 DOI: 10.1021/acschemneuro.5b00298  0.4
2015 Brown PM, Aurousseau MR, Musgaard M, Biggin PC, Bowie D. Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism. The Journal of Physiology. PMID 26682513 DOI: 10.1113/JP271690  0.76
2015 Johnston AJ, Busch S, Pardo LC, Callear SK, Biggin PC, McLain SE. On the atomic structure of cocaine in solution. Physical Chemistry Chemical Physics : Pccp. PMID 26660073 DOI: 10.1039/c5cp06090g  0.76
2015 Heifetz A, Chudyk E, Gleave L, Aldeghi M, Cherezov V, Fedorov DG, Biggin PC, Bodkin M. The Fragment Molecular Orbital Method Reveals New Insight into the Chemical Nature of GPCR-Ligand Interactions. Journal of Chemical Information and Modeling. PMID 26642258 DOI: 10.1021/acs.jcim.5b00644  0.76
2015 Domicevica L, Biggin PC. Homology modelling of human P-glycoprotein. Biochemical Society Transactions. 43: 952-8. PMID 26517909 DOI: 10.1042/BST20150125  0.76
2015 Heifetz A, Bodkin MJ, Biggin PC. Discovery of the First Selective, Nonpeptidic Orexin 2 Receptor Agonists. Journal of Medicinal Chemistry. 58: 7928-30. PMID 26375584 DOI: 10.1021/acs.jmedchem.5b01394  0.76
2015 Ma J, Domicevica L, Schnell JR, Biggin PC. Position and orientational preferences of drug-like compounds in lipid membranes: a computational and NMR approach. Physical Chemistry Chemical Physics : Pccp. 17: 19766-76. PMID 26153345 DOI: 10.1039/c5cp03218k  0.76
2015 Heifetz A, Schertler GF, Seifert R, Tate CG, Sexton PM, Gurevich VV, Fourmy D, Cherezov V, Marshall FH, Storer RI, Moraes I, Tikhonova IG, Tautermann CS, Hunt P, Ceska T, ... ... Biggin PC, et al. GPCR structure, function, drug discovery and crystallography: report from Academia-Industry International Conference (UK Royal Society) Chicheley Hall, 1-2 September 2014. Naunyn-Schmiedeberg's Archives of Pharmacology. 388: 883-903. PMID 25772061 DOI: 10.1007/s00210-015-1111-8  0.76
2015 Lee J, Daniels V, Sands ZA, Lebon F, Shi J, Biggin PC. Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis. Plos One. 10: e0116589. PMID 25692762 DOI: 10.1371/journal.pone.0116589  0.76
2015 Biggin PC, Bond PJ. Molecular dynamics simulations of membrane proteins. Methods in Molecular Biology (Clifton, N.J.). 1215: 91-108. PMID 25330960 DOI: 10.1007/978-1-4939-1465-4_5  0.76
2014 Yu R, Hurdiss E, Greiner T, Lape R, Sivilotti L, Biggin PC. Agonist and antagonist binding in human glycine receptors. Biochemistry. 53: 6041-51. PMID 25184435 DOI: 10.1021/bi500815f  0.76
2014 Kufareva I, Katritch V, Stevens RC, Abagyan R. Advances in GPCR modeling evaluated by the GPCR Dock 2013 assessment: meeting new challenges. Structure (London, England : 1993). 22: 1120-39. PMID 25066135 DOI: 10.1016/j.str.2014.06.012  0.76
2014 Mazzaferro S, Gasparri F, New K, Alcaino C, Faundez M, Iturriaga Vasquez P, Vijayan R, Biggin PC, Bermudez I. Non-equivalent ligand selectivity of agonist sites in (α4β2)2α4 nicotinic acetylcholine receptors: a key determinant of agonist efficacy. The Journal of Biological Chemistry. 289: 21795-806. PMID 24936069 DOI: 10.1074/jbc.M114.555136  0.76
2014 Lees K, Musgaard M, Suwanmanee S, Buckingham SD, Biggin P, Sattelle D. Actions of agonists, fipronil and ivermectin on the predominant in vivo splice and edit variant (RDLbd, I/V) of the Drosophila GABA receptor expressed in Xenopus laevis oocytes. Plos One. 9: e97468. PMID 24823815 DOI: 10.1371/journal.pone.0097468  0.76
2014 Wong K, Ma J, Rothnie A, Biggin PC, Kerr ID. Towards understanding promiscuity in multidrug efflux pumps. Trends in Biochemical Sciences. 39: 8-16. PMID 24316304 DOI: 10.1016/j.tibs.2013.11.002  0.76
2013 Heifetz A, Barker O, Morris GB, Law RJ, Slack M, Biggin PC. Toward an understanding of agonist binding to human Orexin-1 and Orexin-2 receptors with G-protein-coupled receptor modeling and site-directed mutagenesis. Biochemistry. 52: 8246-60. PMID 24144388 DOI: 10.1021/bi401119m  0.76
2013 Ross GA, Morris GM, Biggin PC. One Size Does Not Fit All: The Limits of Structure-Based Models in Drug Discovery. Journal of Chemical Theory and Computation. 9: 4266-4274. PMID 24124403 DOI: 10.1021/ct4004228  0.76
2013 Dawe GB, Musgaard M, Andrews ED, Daniels BA, Aurousseau MR, Biggin PC, Bowie D. Defining the structural relationship between kainate-receptor deactivation and desensitization. Nature Structural & Molecular Biology. 20: 1054-61. PMID 23955023 DOI: 10.1038/nsmb.2654  0.76
2013 Vohra S, Biggin PC. Mutationmapper: a tool to aid the mapping of protein mutation data. Plos One. 8: e71711. PMID 23951226 DOI: 10.1371/journal.pone.0071711  0.76
2013 Vohra S, Musgaard M, Bell SG, Wong LL, Zhou W, Biggin PC. The dynamics of camphor in the cytochrome P450 CYP101D2. Protein Science : a Publication of the Protein Society. 22: 1218-29. PMID 23832606 DOI: 10.1002/pro.2309  0.76
2013 Marcoux J, Wang SC, Politis A, Reading E, Ma J, Biggin PC, Zhou M, Tao H, Zhang Q, Chang G, Morgner N, Robinson CV. Mass spectrometry reveals synergistic effects of nucleotides, lipids, and drugs binding to a multidrug resistance efflux pump. Proceedings of the National Academy of Sciences of the United States of America. 110: 9704-9. PMID 23690617 DOI: 10.1073/pnas.1303888110  0.76
2013 Ma J, Biggin PC. Substrate versus inhibitor dynamics of P-glycoprotein. Proteins. 81: 1653-68. PMID 23670856 DOI: 10.1002/prot.24324  0.76
2013 Biggin PC. Protein dynamics--a moving target: comment on "Comparing proteins by their internal dynamics: exploring structure-function relationships beyond static structural alignments" by C. Micheletti. Physics of Life Reviews. 10: 27-8; discussion 39-. PMID 23122425 DOI: 10.1016/j.plrev.2012.10.005  0.76
2012 Münz M, Hein J, Biggin PC. The role of flexibility and conformational selection in the binding promiscuity of PDZ domains. Plos Computational Biology. 8: e1002749. PMID 23133356 DOI: 10.1371/journal.pcbi.1002749  0.76
2012 Biggin PC. An interview with Philip Biggin, Section Editor for Computational, in silico and modelling studies. Bmc Pharmacology & Toxicology. 13: 2. PMID 22947036 DOI: 10.1186/2050-6511-13-2  0.76
2012 Heifetz A, Morris GB, Biggin PC, Barker O, Fryatt T, Bentley J, Hallett D, Manikowski D, Pal S, Reifegerste R, Slack M, Law R. Study of human Orexin-1 and -2 G-protein-coupled receptors with novel and published antagonists by modeling, molecular dynamics simulations, and site-directed mutagenesis. Biochemistry. 51: 3178-97. PMID 22448975 DOI: 10.1021/bi300136h  0.76
2012 Ross GA, Morris GM, Biggin PC. Rapid and accurate prediction and scoring of water molecules in protein binding sites. Plos One. 7: e32036. PMID 22396746 DOI: 10.1371/journal.pone.0032036  0.76
2012 Münz M, Biggin PC. JGromacs: a Java package for analyzing protein simulations. Journal of Chemical Information and Modeling. 52: 255-9. PMID 22191855 DOI: 10.1021/ci200289s  0.76
2011 Moroni M, Biro I, Giugliano M, Vijayan R, Biggin PC, Beato M, Sivilotti LG. Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14095-106. PMID 21976494 DOI: 10.1523/JNEUROSCI.1985-11.2011  0.76
2011 Mazzaferro S, Benallegue N, Carbone A, Gasparri F, Vijayan R, Biggin PC, Moroni M, Bermudez I. Additional acetylcholine (ACh) binding site at alpha4/alpha4 interface of (alpha4beta2)2alpha4 nicotinic receptor influences agonist sensitivity. The Journal of Biological Chemistry. 286: 31043-54. PMID 21757735 DOI: 10.1074/jbc.M111.262014  0.76
2011 Whitfield T, Miles AJ, Scheinost JC, Offer J, Wentworth P, Dwek RA, Wallace BA, Biggin PC, Zitzmann N. The influence of different lipid environments on the structure and function of the hepatitis C virus p7 ion channel protein. Molecular Membrane Biology. 28: 254-64. PMID 21604991 DOI: 10.3109/09687688.2011.581253  0.76
2011 Sahai MA, Biggin PC. Quantifying water-mediated protein-ligand interactions in a glutamate receptor: a DFT study. The Journal of Physical Chemistry. B. 115: 7085-96. PMID 21545106 DOI: 10.1021/jp200776t  0.76
2010 Vohra S, Hall BA, Holdbrook DA, Khalid S, Biggin PC. Bookshelf: a simple curation system for the storage of biomolecular simulation data. Database : the Journal of Biological Databases and Curation. 2010: baq033. PMID 21169341 DOI: 10.1093/database/baq033  0.76
2010 Vijayan R, Sahai MA, Czajkowski T, Biggin PC. A comparative analysis of the role of water in the binding pockets of ionotropic glutamate receptors. Physical Chemistry Chemical Physics : Pccp. 12: 14057-66. PMID 20856958 DOI: 10.1039/c004336b  0.76
2010 Iturriaga-Vásquez P, Carbone A, García-Beltrán O, Livingstone PD, Biggin PC, Cassels BK, Wonnacott S, Zapata-Torres G, Bermudez I. Molecular determinants for competitive inhibition of alpha4beta2 nicotinic acetylcholine receptors. Molecular Pharmacology. 78: 366-75. PMID 20547737 DOI: 10.1124/mol.110.065490  0.76
2010 Münz M, Lyngsø R, Hein J, Biggin PC. Dynamics based alignment of proteins: an alternative approach to quantify dynamic similarity. Bmc Bioinformatics. 11: 188. PMID 20398246 DOI: 10.1186/1471-2105-11-188  0.76
2010 Vijayan R, Biggin PC. Conformational preferences of a 14-residue fibrillogenic peptide from acetylcholinesterase. Biochemistry. 49: 3678-84. PMID 20356043 DOI: 10.1021/bi1001807  0.76
2009 Luik P, Chew C, Aittoniemi J, Chang J, Wentworth P, Dwek RA, Biggin PC, Vénien-Bryan C, Zitzmann N. The 3-dimensional structure of a hepatitis C virus p7 ion channel by electron microscopy. Proceedings of the National Academy of Sciences of the United States of America. 106: 12712-6. PMID 19590017 DOI: 10.1073/pnas.0905966106  0.76
2009 Vijayan R, Plested AJ, Mayer ML, Biggin PC. Selectivity and cooperativity of modulatory ions in a neurotransmitter receptor. Biophysical Journal. 96: 1751-60. PMID 19254535 DOI: 10.1016/j.bpj.2008.11.039  0.76
2009 Chew CF, Vijayan R, Chang J, Zitzmann N, Biggin PC. Determination of pore-lining residues in the hepatitis C virus p7 protein. Biophysical Journal. 96: L10-2. PMID 19167280 DOI: 10.1016/j.bpj.2008.10.004  0.76
2008 Chew CF, Guy A, Biggin PC. Distribution and dynamics of adamantanes in a lipid bilayer. Biophysical Journal. 95: 5627-36. PMID 18835906 DOI: 10.1529/biophysj.108.139477  0.76
2008 Vijayan R, Biggin PC. A steroid in a lipid bilayer: localization, orientation, and energetics. Biophysical Journal. 95: L45-7. PMID 18689457 DOI: 10.1529/biophysj.108.140087  0.76
2008 Moroni M, Vijayan R, Carbone A, Zwart R, Biggin PC, Bermudez I. Non-agonist-binding subunit interfaces confer distinct functional signatures to the alternate stoichiometries of the alpha4beta2 nicotinic receptor: an alpha4-alpha4 interface is required for Zn2+ potentiation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6884-94. PMID 18596163 DOI: 10.1523/JNEUROSCI.1228-08.2008  0.76
2008 Plested AJ, Vijayan R, Biggin PC, Mayer ML. Molecular basis of kainate receptor modulation by sodium. Neuron. 58: 720-35. PMID 18549784 DOI: 10.1016/j.neuron.2008.04.001  0.76
2008 Biggin PC, Bond PJ. Molecular dynamics simulations of membrane proteins. Methods in Molecular Biology (Clifton, N.J.). 443: 147-60. PMID 18446286 DOI: 10.1007/978-1-59745-177-2_8  0.76
2008 Amiri S, Shimomura M, Vijayan R, Nishiwaki H, Akamatsu M, Matsuda K, Jones AK, Sansom MS, Biggin PC, Sattelle DB. A role for Leu118 of loop E in agonist binding to the alpha 7 nicotinic acetylcholine receptor. Molecular Pharmacology. 73: 1659-67. PMID 18339894 DOI: 10.1124/mol.107.041590  0.76
2008 Bjerrum EJ, Biggin PC. Rigid body essential X-ray crystallography: distinguishing the bend and twist of glutamate receptor ligand binding domains. Proteins. 72: 434-46. PMID 18214958 DOI: 10.1002/prot.21941  0.76
2007 Hall BA, Kaye SL, Pang A, Perera R, Biggin PC. Characterization of protein conformational states by normal-mode frequencies. Journal of the American Chemical Society. 129: 11394-401. PMID 17715919 DOI: 10.1021/ja071797y  0.76
2007 Amiri S, Sansom MS, Biggin PC. Molecular dynamics studies of AChBP with nicotine and carbamylcholine: the role of water in the binding pocket. Protein Engineering, Design & Selection : Peds. 20: 353-9. PMID 17595341 DOI: 10.1093/protein/gzm029  0.76
2007 Kaye SL, Sansom MS, Biggin PC. In silico mutation of cysteine residues in the ligand-binding domain of an N-methyl-D-aspartate receptor. Biochemistry. 46: 2136-45. PMID 17269660 DOI: 10.1021/bi061462d  0.76
2006 Kaye SL, Sansom MS, Biggin PC. Molecular dynamics simulations of the ligand-binding domain of an N-methyl-D-aspartate receptor. The Journal of Biological Chemistry. 281: 12736-42. PMID 16513640 DOI: 10.1074/jbc.M512728200  0.76
2006 Arinaminpathy Y, Sansom MS, Biggin PC. Binding site flexibility: molecular simulation of partial and full agonists within a glutamate receptor. Molecular Pharmacology. 69: 11-8. PMID 16219907 DOI: 10.1124/mol.105.016691  0.76
2005 Pang A, Arinaminpathy Y, Sansom MS, Biggin PC. Comparative molecular dynamics--similar folds and similar motions? Proteins. 61: 809-22. PMID 16231327 DOI: 10.1002/prot.20672  0.76
2005 Amiri S, Tai K, Beckstein O, Biggin PC, Sansom MS. The alpha7 nicotinic acetylcholine receptor: molecular modelling, electrostatics, and energetics. Molecular Membrane Biology. 22: 151-62. PMID 16096259 DOI: 10.1080/09687860500063340  0.76
2005 Buckingham SD, Biggin PC, Sattelle BM, Brown LA, Sattelle DB. Insect GABA receptors: splicing, editing, and targeting by antiparasitics and insecticides. Molecular Pharmacology. 68: 942-51. PMID 16027231 DOI: 10.1124/mol.105.015313  0.76
2005 Sattelle DB, Jones AK, Sattelle BM, Matsuda K, Reenan R, Biggin PC. Edit, cut and paste in the nicotinic acetylcholine receptor gene family of Drosophila melanogaster. Bioessays : News and Reviews in Molecular, Cellular and Developmental Biology. 27: 366-76. PMID 15770687 DOI: 10.1002/bies.20207  0.76
2005 Buckingham SD, Pym L, Jones AK, Brown L, Sansom MS, Sattelle DB, Biggin PC. A7DB: a relational database for mutational, physiological and pharmacological data related to the alpha7 nicotinic acetylcholine receptor. Bmc Neuroscience. 6: 2. PMID 15661073 DOI: 10.1186/1471-2202-6-2  0.76
2003 Beckstein O, Biggin PC, Bond P, Bright JN, Domene C, Grottesi A, Holyoake J, Sansom MS. Ion channel gating: insights via molecular simulations. Febs Letters. 555: 85-90. PMID 14630324 DOI: 10.1016/S0014-5793(03)01151-7  0.76
2003 Arinaminpathy Y, Biggin PC, Shrivastava IH, Sansom MS. A prokaryotic glutamate receptor: homology modelling and molecular dynamics simulations of GluR0. Febs Letters. 553: 321-7. PMID 14572644 DOI: 10.1016/S0014-5793(03)01036-6  0.76
2003 Pang A, Arinaminpathy Y, Sansom MS, Biggin PC. Interdomain dynamics and ligand binding: molecular dynamics simulations of glutamine binding protein. Febs Letters. 550: 168-74. PMID 12935905 DOI: 10.1016/S0014-5793(03)00866-4  0.76
2003 Campbell JD, Biggin PC, Baaden M, Sansom MS. Extending the structure of an ABC transporter to atomic resolution: modeling and simulation studies of MsbA. Biochemistry. 42: 3666-73. PMID 12667056 DOI: 10.1021/bi027337t  0.76
2003 Biggin PC, Sansom MS. Mechanosensitive channels: stress relief. Current Biology : Cb. 13: R183-5. PMID 12620208 DOI: 10.1016/S0960-9822(03)00119-2  0.76
2002 Sansom MS, Shrivastava IH, Bright JN, Tate J, Capener CE, Biggin PC. Potassium channels: structures, models, simulations. Biochimica Et Biophysica Acta. 1565: 294-307. PMID 12409202 DOI: 10.1016/S0005-2736(02)00576-X  0.76
2002 Biggin PC. Glutamate receptors: desensitizing dimers. Current Biology : Cb. 12: R631-2. PMID 12372271 DOI: 10.1016/S0960-9822(02)01138-7  0.76
2002 Biggin PC, Sansom MS. Open-state models of a potassium channel. Biophysical Journal. 83: 1867-76. PMID 12324408 DOI: 10.1016/S0006-3495(02)73951-9  0.76
2002 Shrivastava IH, Tieleman DP, Biggin PC, Sansom MS. K(+) versus Na(+) ions in a K channel selectivity filter: a simulation study. Biophysical Journal. 83: 633-45. PMID 12124253  0.76
2002 Sansom MS, Bond P, Beckstein O, Biggin PC, Faraldo-Gómez J, Law RJ, Patargias G, Tieleman DP. Water in ion channels and pores--simulation studies. Novartis Foundation Symposium. 245: 66-78; discussion 79. PMID 12027016  0.76
2002 Arinaminpathy Y, Sansom MS, Biggin PC. Molecular dynamics simulations of the ligand-binding domain of the ionotropic glutamate receptor GluR2. Biophysical Journal. 82: 676-83. PMID 11806910 DOI: 10.1016/S0006-3495(02)75430-1  0.76
2001 Tieleman DP, Biggin PC, Smith GR, Sansom MS. Simulation approaches to ion channel structure-function relationships. Quarterly Reviews of Biophysics. 34: 473-561. PMID 11852594  0.76
2001 Sansom MS, Biggin PC. Water at the nanoscale. Nature. 414: 156-9. PMID 11700536 DOI: 10.1038/35102651  0.76
2001 Biggin PC, Sansom MS. Channel gating: twist to open. Current Biology : Cb. 11: R364-6. PMID 11369249 DOI: 10.1016/S0960-9822(01)00195-6  0.76
2001 Biggin PC, Smith GR, Shrivastava I, Choe S, Sansom MS. Potassium and sodium ions in a potassium channel studied by molecular dynamics simulations. Biochimica Et Biophysica Acta. 1510: 1-9. PMID 11342142 DOI: 10.1016/S0005-2736(00)00345-X  0.76
2001 Beckstein O, Biggin PC, Sansom MSP. A hydrophobic gating mechanism for nanopores Journal of Physical Chemistry B. 105: 12902-12905. DOI: 10.1021/jp012233y  0.76
2000 Biggin PC, Roosild T, Choe S. Potassium channel structure: domain by domain. Current Opinion in Structural Biology. 10: 456-61. PMID 10981635 DOI: 10.1016/S0959-440X(00)00114-7  0.76
1999 La Rocca P, Biggin PC, Tieleman DP, Sansom MS. Simulation studies of the interaction of antimicrobial peptides and lipid bilayers. Biochimica Et Biophysica Acta. 1462: 185-200. PMID 10590308 DOI: 10.1016/S0005-2736(99)00206-0  0.76
1999 Biggin PC, Sansom MS. Interactions of alpha-helices with lipid bilayers: a review of simulation studies. Biophysical Chemistry. 76: 161-83. PMID 10074693 DOI: 10.1016/S0301-4622(98)00233-6  0.76
1999 Helluin O, Cosette P, Biggin PC, Sansom MSP, Duclohier H. Functional, structural and molecular dynamics correlates of voltage sensors: implications for gating mechanisms Ferroelectrics. 220: 329-341.  0.76
1997 Jaikaran DC, Biggin PC, Wenschuh H, Sansom MS, Woolley GA. Structure-function relationships in helix-bundle channels probed via total chemical synthesis of alamethicin dimers: effects of a Gln7 to Asn7 mutation. Biochemistry. 36: 13873-81. PMID 9374865 DOI: 10.1021/bi9716130  0.76
1997 Sansom MS, Smith GR, Adcock C, Biggin PC. The dielectric properties of water within model transbilayer pores. Biophysical Journal. 73: 2404-15. PMID 9370434 DOI: 10.1016/S0006-3495(97)78269-9  0.76
1997 Woolley GA, Biggin PC, Schultz A, Lien L, Jaikaran DC, Breed J, Crowhurst K, Sansom MS. Intrinsic rectification of ion flux in alamethicin channels: studies with an alamethicin dimer. Biophysical Journal. 73: 770-8. PMID 9251793 DOI: 10.1016/S0006-3495(97)78109-8  0.76
1997 Breed J, Biggin PC, Kerr ID, Smart OS, Sansom MS. Alamethicin channels - modelling via restrained molecular dynamics simulations. Biochimica Et Biophysica Acta. 1325: 235-49. PMID 9168149 DOI: 10.1016/S0005-2736(96)00262-3  0.76
1997 Biggin PC, Breed J, Son HS, Sansom MS. Simulation studies of alamethicin-bilayer interactions. Biophysical Journal. 72: 627-36. PMID 9017192  0.76
1996 Biggin PC, Sansom MS. Simulation of voltage-dependent interactions of alpha-helical peptides with lipid bilayers. Biophysical Chemistry. 60: 99-110. PMID 8679929 DOI: 10.1016/0301-4622(96)00015-4  0.76
1996 Biggin PC, Sansom MS. Simulation of voltage-dependent insertion of alpha-helical peptides into lipid bilayers. Biochemical Society Transactions. 24: 137S. PMID 8674627  0.76
1996 Gazit E, Miller IR, Biggin PC, Sansom MS, Shai Y. Structure and orientation of the mammalian antibacterial peptide cecropin P1 within phospholipid membranes. Journal of Molecular Biology. 258: 860-70. PMID 8637016 DOI: 10.1006/jmbi.1996.0293  0.76
Show low-probability matches.