| Year |
Citation |
Score |
| 2024 |
Zaki AM, Çınaroğlu SS, Rahman T, Patel S, Biggin PC. Plasticity of the selectivity filter is essential for permeation in lysosomal TPC2 channels. Proceedings of the National Academy of Sciences of the United States of America. 121: e2320153121. PMID 39074274 DOI: 10.1073/pnas.2320153121 |
0.369 |
|
| 2024 |
Seiferth D, Biggin PC. Exploring the influence of pore shape on conductance and permeation. Biophysical Journal. PMID 38973159 DOI: 10.1016/j.bpj.2024.07.010 |
0.372 |
|
| 2024 |
Wu Z, Smith K, Gerondopoulos A, Sobajima T, Parker JL, Barr FA, Newstead S, Biggin PC. Molecular basis for pH sensing in the KDEL trafficking receptor. Structure (London, England : 1993). PMID 38626766 DOI: 10.1016/j.str.2024.03.013 |
0.32 |
|
| 2024 |
Bharambe N, Li Z, Seiferth D, Balakrishna AM, Biggin PC, Basak S. Cryo-EM structures of prokaryotic ligand-gated ion channel GLIC provide insights into gating in a lipid environment. Nature Communications. 15: 2967. PMID 38580666 DOI: 10.1038/s41467-024-47370-w |
0.338 |
|
| 2024 |
Larsen AH, Perozzo AM, Biggin PC, Bowie D, Kastrup JS. Recovery from desensitization in GluA2 AMPA receptors is affected by a single mutation in the N-terminal domain interface. The Journal of Biological Chemistry. 300: 105717. PMID 38311178 DOI: 10.1016/j.jbc.2024.105717 |
0.593 |
|
| 2023 |
Bay Y, Venskutonytė R, Frantsen SM, Thorsen TS, Musgaard M, Frydenvang K, Francotte P, Pirotte B, Biggin PC, Kristensen AS, Boesen T, Pickering DS, Gajhede M, Kastrup JS. Small-molecule positive allosteric modulation of homomeric kainate receptors GluK1-3: development of screening assays and insight into GluK3 structure. The Febs Journal. PMID 38145505 DOI: 10.1111/febs.17046 |
0.478 |
|
| 2023 |
Viscarra F, Chrestia JF, Sanchez Y, Pérez EG, Biggin PC, Bouzat C, Bermudez I, López JJ. Side Groups Convert the α7 Nicotinic Receptor Agonist Ether Quinuclidine into a Type I Positive Allosteric Modulator. Acs Chemical Neuroscience. 14: 2876-2887. PMID 37535446 DOI: 10.1021/acschemneuro.3c00225 |
0.381 |
|
| 2023 |
Seiferth D, Tucker SJ, Biggin PC. Limitations of non-polarizable force fields in describing anion binding poses in non-polar synthetic hosts. Physical Chemistry Chemical Physics : Pccp. 25: 17596-17608. PMID 37365974 DOI: 10.1039/d3cp00479a |
0.317 |
|
| 2023 |
Gibbs E, Klemm E, Seiferth D, Kumar A, Ilca SL, Biggin PC, Chakrapani S. Conformational transitions and allosteric modulation in a heteromeric glycine receptor. Nature Communications. 14: 1363. PMID 36914669 DOI: 10.1038/s41467-023-37106-7 |
0.396 |
|
| 2022 |
Seiferth D, Biggin PC, Tucker SJ. When is a hydrophobic gate not a hydrophobic gate? The Journal of General Physiology. 154. PMID 36287215 DOI: 10.1085/jgp.202213210 |
0.353 |
|
| 2022 |
Kumar A, Kindig K, Rao S, Zaki AM, Basak S, Sansom MSP, Biggin PC, Chakrapani S. Structural basis for cannabinoid-induced potentiation of alpha1-glycine receptors in lipid nanodiscs. Nature Communications. 13: 4862. PMID 35982060 DOI: 10.1038/s41467-022-32594-5 |
0.408 |
|
| 2022 |
Chou TH, Epstein M, Michalski K, Fine E, Biggin PC, Furukawa H. Structural insights into binding of therapeutic channel blockers in NMDA receptors. Nature Structural & Molecular Biology. 29: 507-518. PMID 35637422 DOI: 10.1038/s41594-022-00772-0 |
0.487 |
|
| 2022 |
Ladefoged LK, Koch R, Biggin PC, Schiøtt B. Binding and Activation of Serotonergic G-Protein Coupled Receptors by the Multimodal Antidepressant Vortioxetine. Acs Chemical Neuroscience. 13: 1129-1142. PMID 35348335 DOI: 10.1021/acschemneuro.1c00029 |
0.351 |
|
| 2022 |
Habgood M, Seiferth D, Zaki AM, Alibay I, Biggin PC. Atomistic mechanisms of human TRPA1 activation by electrophile irritants through molecular dynamics simulation and mutual information analysis. Scientific Reports. 12: 4929. PMID 35322090 DOI: 10.1038/s41598-022-08824-7 |
0.365 |
|
| 2022 |
Mancino AS, Glass WG, Yan Y, Biggin PC, Bowie D. Spliced isoforms of the cardiac Nav1.5 channel modify channel activation by distinct structural mechanisms. The Journal of General Physiology. 154. PMID 35297947 DOI: 10.1085/jgp.202112906 |
0.62 |
|
| 2021 |
Patel S, Gunaratne GS, Marchant JS, Biggin PC, Rahman T. NAADP receptors: A one-two. Cell Calcium. 100: 102478. PMID 34600271 DOI: 10.1016/j.ceca.2021.102478 |
0.316 |
|
| 2021 |
Gerondopoulos A, Bräuer P, Sobajima T, Wu Z, Parker JL, Biggin P, Barr FA, Newstead S. A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval. Elife. 10. PMID 34137369 DOI: 10.7554/eLife.68380 |
0.353 |
|
| 2021 |
Gerondopoulos A, Bräuer P, Sobajima T, Wu Z, Parker JL, Biggin P, Barr FA, Newstead S. A signal capture and proofreading mechanism for the KDEL-receptor explains selectivity and dynamic range in ER retrieval. Elife. 10. PMID 34137369 DOI: 10.7554/eLife.68380 |
0.353 |
|
| 2021 |
Dämgen MA, Biggin PC. State-dependent protein-lipid interactions of a pentameric ligand-gated ion channel in a neuronal membrane. Plos Computational Biology. 17: e1007856. PMID 33571182 DOI: 10.1371/journal.pcbi.1007856 |
0.405 |
|
| 2020 |
Wu Z, Newstead S, Biggin PC. The KDEL trafficking receptor exploits pH to tune the strength of an unusual short hydrogen bond. Scientific Reports. 10: 16903. PMID 33037300 DOI: 10.1038/s41598-020-73906-3 |
0.352 |
|
| 2020 |
Busch JMC, Matsoukas MT, Musgaard M, Spyroulias GA, Biggin PC, Vakonakis I. Identification of compounds that bind the centriolar protein SAS-6 and inhibit its oligomerisation. The Journal of Biological Chemistry. PMID 32873708 DOI: 10.1074/Jbc.Ra120.014780 |
0.31 |
|
| 2020 |
Dämgen MA, Zaki AM, Biggin PC. Comment on "On the Functional Annotation of Open-Channel Structures in the Glycine Receptor". Structure (London, England : 1993). 28: 601-603. PMID 32492412 DOI: 10.1016/j.str.2020.04.021 |
0.33 |
|
| 2019 |
Dämgen MA, Biggin PC. A Refined Open State of the Glycine Receptor Obtained via Molecular Dynamics Simulations. Structure (London, England : 1993). PMID 31753620 DOI: 10.1016/j.str.2019.10.019 |
0.435 |
|
| 2019 |
Stenum-Berg C, Musgaard M, Chavez-Abiega S, Thisted CL, Barrella L, Biggin PC, Kristensen AS. Mutational analysis and modeling of negative allosteric modulator binding sites in AMPA receptors. Molecular Pharmacology. PMID 31582576 DOI: 10.1124/Mol.119.116871 |
0.549 |
|
| 2019 |
Cetin H, Epstein M, Liu WW, Maxwell S, Rodriguez Cruz PM, Cossins J, Vincent A, Webster R, Biggin PC, Beeson D. Muscle acetylcholine receptor conversion into chloride conductance at positive potentials by a single mutation. Proceedings of the National Academy of Sciences of the United States of America. PMID 31570625 DOI: 10.1073/pnas.1908284116 |
0.418 |
|
| 2018 |
Dämgen MA, Biggin PC. Computational methods to examine conformational changes and ligand-binding properties: Examples in neurobiology. Neuroscience Letters. PMID 29518541 DOI: 10.1016/j.neulet.2018.03.004 |
0.361 |
|
| 2018 |
Dämgen MA, Greiner T, Lape R, Sivilotti LG, Biggin PC. Alternative Binding Mode of Full and Partial Agonists in a Pentameric Ligand-Gated Ion Channel Stabilises Loop C in an Open Conformation Biophysical Journal. 114: 297a. DOI: 10.1016/J.Bpj.2017.11.1694 |
0.685 |
|
| 2017 |
Laverty D, Thomas P, Field M, Andersen OJ, Gold MG, Biggin PC, Gielen M, Smart TG. Crystal structures of a GABAA-receptor chimera reveal new endogenous neurosteroid-binding sites. Nature Structural & Molecular Biology. PMID 28967882 DOI: 10.1038/Nsmb.3477 |
0.343 |
|
| 2017 |
Paramo T, Brown PMGE, Musgaard M, Bowie D, Biggin PC. Functional Validation of Heteromeric Kainate Receptor Models. Biophysical Journal. PMID 28935133 DOI: 10.1016/J.Bpj.2017.08.047 |
0.668 |
|
| 2017 |
Musgaard M, Paramo T, Domicevica L, Andersen OJ, Biggin PC. Insights into channel dysfunction from modelling and molecular dynamics simulations. Neuropharmacology. PMID 28669899 DOI: 10.1016/j.neuropharm.2017.06.030 |
0.368 |
|
| 2017 |
Safar F, Hurdiss E, Erotocritou M, Greiner T, Lape R, Irvine MW, Fang G, Jane D, Yu R, Dämgen MA, Biggin PC, Sivilotti LG. The startle disease mutation E103K impairs activation of human homomeric α1 glycine receptors by disrupting an intersubunit salt bridge across the agonist binding site. The Journal of Biological Chemistry. PMID 28174298 DOI: 10.1074/Jbc.M116.767616 |
0.696 |
|
| 2017 |
Dämgen MA, Greiner T, Lape R, Sivilotti LG, Biggin PC. Binding Modes of Full and Partial Agonists in the Orthosteric Binding Site of the Glycine Receptor Biophysical Journal. 112: 556a. DOI: 10.1016/J.Bpj.2016.11.2997 |
0.715 |
|
| 2016 |
Alcaino C, Musgaard M, Minguez T, Mazzaferro S, Faundez M, Iturriaga-Vasquez P, Biggin PC, Bermudez I. Role of the Cys loop and transmembrane domain in the allosteric modulation of α4β2 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. PMID 27864368 DOI: 10.1074/Jbc.M116.751206 |
0.421 |
|
| 2016 |
Musgaard M, Biggin PC. Steered Molecular Dynamics Simulations Predict Conformational Stability of Glutamate Receptors. Journal of Chemical Information and Modeling. PMID 27482759 DOI: 10.1021/acs.jcim.6b00297 |
0.493 |
|
| 2016 |
Heifetz A, James T, Morao I, Bodkin MJ, Biggin PC. Guiding lead optimization with GPCR structure modeling and molecular dynamics. Current Opinion in Pharmacology. 30: 14-21. PMID 27419904 DOI: 10.1016/j.coph.2016.06.004 |
0.392 |
|
| 2016 |
Heifetz A, Aldeghi M, Chudyk EI, Fedorov DG, Bodkin MJ, Biggin PC. Using the fragment molecular orbital method to investigate agonist-orexin-2 receptor interactions. Biochemical Society Transactions. 44: 574-81. PMID 27068972 DOI: 10.1042/BST20150250 |
0.347 |
|
| 2016 |
Dawe GB, Musgaard M, Aurousseau MR, Nayeem N, Green T, Biggin PC, Bowie D. Distinct Structural Pathways Coordinate the Activation of AMPA Receptor-Auxiliary Subunit Complexes. Neuron. PMID 26924438 DOI: 10.1016/J.Neuron.2016.01.038 |
0.664 |
|
| 2016 |
Heifetz A, Storer RI, McMurray G, James T, Morao I, Aldeghi M, Bodkin MJ, Biggin PC. Application of an Integrated GPCR SAR-Modelling Platform to Explain the Activation Selectivity of Human 5-HT2C over 5-HT2B. Acs Chemical Biology. PMID 26900768 DOI: 10.1021/acschembio.5b01045 |
0.316 |
|
| 2016 |
Braun N, Lynagh T, Yu R, Biggin PC, Pless SA. The role of an absolutely conserved tryptophan pair in the extracellular domain of Cys-loop receptors. Acs Chemical Neuroscience. PMID 26764897 DOI: 10.1021/Acschemneuro.5B00298 |
0.393 |
|
| 2016 |
Braun N, Lynagh T, Yu R, Biggin PC, Pless SA. The Role of a Tryptophan Cluster in the Extracelluar Domain of Cys-Loop Receptors Biophysical Journal. 110: 602a. DOI: 10.1016/J.Bpj.2015.11.3216 |
0.345 |
|
| 2016 |
Paramo T, Brown PM, Aurousseau MR, Musgaard M, Bowie D, Biggin PC. Functional and Structural Characterization of the GluK2/GluK5 Heterotetramer Gating Mechanism Biophysical Journal. 110: 289a. DOI: 10.1016/J.Bpj.2015.11.1565 |
0.708 |
|
| 2015 |
Brown PM, Aurousseau MR, Musgaard M, Biggin PC, Bowie D. Kainate receptor pore-forming and auxiliary subunits regulate channel block by a novel mechanism. The Journal of Physiology. PMID 26682513 DOI: 10.1113/Jp271690 |
0.647 |
|
| 2015 |
Lee J, Daniels V, Sands ZA, Lebon F, Shi J, Biggin PC. Exploring the interaction of SV2A with racetams using homology modelling, molecular dynamics and site-directed mutagenesis. Plos One. 10: e0116589. PMID 25692762 DOI: 10.1371/journal.pone.0116589 |
0.366 |
|
| 2015 |
Musgaard M, Daniels B, Dawe GB, Aurousseau M, Bowie D, Biggin PC. Can Activation and Desensitization Properties of iGluRs Be Predicted and Understood by Studying the LBD Dimer Dynamics? Biophysical Journal. 108: 287a-288a. DOI: 10.1016/J.Bpj.2014.11.1570 |
0.69 |
|
| 2015 |
Dawe GB, Musgaard M, Aurousseau MR, Biggin PC, Bowie D. Characterization of a “Hotspot” in the AMPA Receptor Activation Pathway Biophysical Journal. 108: 287a. DOI: 10.1016/J.Bpj.2014.11.1565 |
0.712 |
|
| 2015 |
Yu R, Biggin PC. Conformational Dynamics in the GABAA Receptor Biophysical Journal. 108: 192a. DOI: 10.1016/J.Bpj.2014.11.1062 |
0.5 |
|
| 2014 |
Yu R, Hurdiss E, Greiner T, Lape R, Sivilotti L, Biggin PC. Agonist and antagonist binding in human glycine receptors. Biochemistry. 53: 6041-51. PMID 25184435 DOI: 10.1021/Bi500815F |
0.738 |
|
| 2014 |
Mazzaferro S, Gasparri F, New K, Alcaino C, Faundez M, Iturriaga Vasquez P, Vijayan R, Biggin PC, Bermudez I. Non-equivalent ligand selectivity of agonist sites in (α4β2)2α4 nicotinic acetylcholine receptors: a key determinant of agonist efficacy. The Journal of Biological Chemistry. 289: 21795-806. PMID 24936069 DOI: 10.1074/Jbc.M114.555136 |
0.361 |
|
| 2014 |
Lees K, Musgaard M, Suwanmanee S, Buckingham SD, Biggin P, Sattelle D. Actions of agonists, fipronil and ivermectin on the predominant in vivo splice and edit variant (RDLbd, I/V) of the Drosophila GABA receptor expressed in Xenopus laevis oocytes. Plos One. 9: e97468. PMID 24823815 DOI: 10.1371/Journal.Pone.0097468 |
0.388 |
|
| 2014 |
Daniels BA, Aurousseau MR, Musgaard M, Dawe GB, Biggin PC, Bowie D. Functional Consequences of Cysteine Mutations at the Kainate Receptor Dimer Interface Biophysical Journal. 106: 150a. DOI: 10.1016/J.Bpj.2013.11.864 |
0.593 |
|
| 2014 |
Greiner T, Hurdiss E, Yu R, Lape R, Biggin PC, Sivilotti LG. Interaction of the Glycine Receptor Alpha 1 Binding Site with Partial Agonists Biophysical Journal. 106: 547a. DOI: 10.1016/J.Bpj.2013.11.3047 |
0.731 |
|
| 2014 |
Musgaard M, Barber J, bin Imtiaz MK, Biggin PC. Regulatory Ions Bound at the iGluR Ligand Binding Domain Dimer Interface - A Shared Property of GluK2 and AvGluR1? Biophysical Journal. 106: 29a. DOI: 10.1016/j.bpj.2013.11.213 |
0.359 |
|
| 2014 |
Heifetz A, Barker O, Morris GB, Law RJ, Slack M, Biggin PC. Combining Modelling and Site-Directed Mutagenesis to Explore Agonist Binding to Human Orexin Receptors Biophysical Journal. 106: 14a. DOI: 10.1016/j.bpj.2013.11.132 |
0.38 |
|
| 2013 |
Heifetz A, Barker O, Morris GB, Law RJ, Slack M, Biggin PC. Toward an understanding of agonist binding to human Orexin-1 and Orexin-2 receptors with G-protein-coupled receptor modeling and site-directed mutagenesis. Biochemistry. 52: 8246-60. PMID 24144388 DOI: 10.1021/bi401119m |
0.39 |
|
| 2013 |
Dawe GB, Musgaard M, Andrews ED, Daniels BA, Aurousseau MR, Biggin PC, Bowie D. Defining the structural relationship between kainate-receptor deactivation and desensitization. Nature Structural & Molecular Biology. 20: 1054-61. PMID 23955023 DOI: 10.1038/Nsmb.2654 |
0.689 |
|
| 2013 |
Vohra S, Musgaard M, Bell SG, Wong LL, Zhou W, Biggin PC. The dynamics of camphor in the cytochrome P450 CYP101D2. Protein Science : a Publication of the Protein Society. 22: 1218-29. PMID 23832606 DOI: 10.1002/Pro.2309 |
0.32 |
|
| 2013 |
Musgaard M, Daniels B, Andrews E, Dawe GB, Aurousseau M, Bowie D, Biggin PC. Atomistic Simulations Explain Mutational Effects on Ion Modulation and Kainate Receptor Activity Biophysical Journal. 104: 274a-275a. DOI: 10.1016/J.Bpj.2012.11.1539 |
0.675 |
|
| 2013 |
Dawe GB, Daniels BA, Andrews ED, Aurousseau MR, Musgaard M, Biggin PC, Bowie D. Re-Evaluating a Proposed Mechanism for Ion Modulation in Kainate Receptors Biophysical Journal. 104: 274a. DOI: 10.1016/J.Bpj.2012.11.1538 |
0.674 |
|
| 2012 |
Münz M, Hein J, Biggin PC. The role of flexibility and conformational selection in the binding promiscuity of PDZ domains. Plos Computational Biology. 8: e1002749. PMID 23133356 DOI: 10.1371/journal.pcbi.1002749 |
0.367 |
|
| 2012 |
Heifetz A, Morris GB, Biggin PC, Barker O, Fryatt T, Bentley J, Hallett D, Manikowski D, Pal S, Reifegerste R, Slack M, Law R. Study of human Orexin-1 and -2 G-protein-coupled receptors with novel and published antagonists by modeling, molecular dynamics simulations, and site-directed mutagenesis. Biochemistry. 51: 3178-97. PMID 22448975 DOI: 10.1021/bi300136h |
0.428 |
|
| 2012 |
Vijayan R, Biggin PC. An Ionic Switch in the Ligand-Binding Domain of Non-NMDA Receptors Biophysical Journal. 102: 613a. DOI: 10.1016/j.bpj.2011.11.3341 |
0.408 |
|
| 2011 |
Moroni M, Biro I, Giugliano M, Vijayan R, Biggin PC, Beato M, Sivilotti LG. Chloride ions in the pore of glycine and GABA channels shape the time course and voltage dependence of agonist currents. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14095-106. PMID 21976494 DOI: 10.1523/JNEUROSCI.1985-11.2011 |
0.665 |
|
| 2011 |
Mazzaferro S, Benallegue N, Carbone A, Gasparri F, Vijayan R, Biggin PC, Moroni M, Bermudez I. Additional acetylcholine (ACh) binding site at alpha4/alpha4 interface of (alpha4beta2)2alpha4 nicotinic receptor influences agonist sensitivity. The Journal of Biological Chemistry. 286: 31043-54. PMID 21757735 DOI: 10.1074/jbc.M111.262014 |
0.418 |
|
| 2011 |
Sahai MA, Biggin PC. Quantifying water-mediated protein-ligand interactions in a glutamate receptor: a DFT study. The Journal of Physical Chemistry. B. 115: 7085-96. PMID 21545106 DOI: 10.1021/Jp200776T |
0.71 |
|
| 2010 |
Vijayan R, Sahai MA, Czajkowski T, Biggin PC. A comparative analysis of the role of water in the binding pockets of ionotropic glutamate receptors. Physical Chemistry Chemical Physics : Pccp. 12: 14057-66. PMID 20856958 DOI: 10.1039/C004336B |
0.715 |
|
| 2010 |
Iturriaga-Vásquez P, Carbone A, GarcÃa-Beltrán O, Livingstone PD, Biggin PC, Cassels BK, Wonnacott S, Zapata-Torres G, Bermudez I. Molecular determinants for competitive inhibition of alpha4beta2 nicotinic acetylcholine receptors. Molecular Pharmacology. 78: 366-75. PMID 20547737 DOI: 10.1124/mol.110.065490 |
0.357 |
|
| 2010 |
Vijayan R, Biggin PC. A Comparative Molecular Dynamics Simulation Study of the Amino Terminal Domain of Ionotropic Glutamate Receptors Biophysical Journal. 98: 524a. DOI: 10.1016/j.bpj.2009.12.2847 |
0.327 |
|
| 2009 |
Vijayan R, Plested AJ, Mayer ML, Biggin PC. Selectivity and cooperativity of modulatory ions in a neurotransmitter receptor. Biophysical Journal. 96: 1751-60. PMID 19254535 DOI: 10.1016/J.Bpj.2008.11.039 |
0.505 |
|
| 2008 |
Plested AJ, Vijayan R, Biggin PC, Mayer ML. Molecular basis of kainate receptor modulation by sodium. Neuron. 58: 720-35. PMID 18549784 DOI: 10.1016/J.Neuron.2008.04.001 |
0.492 |
|
| 2008 |
Amiri S, Shimomura M, Vijayan R, Nishiwaki H, Akamatsu M, Matsuda K, Jones AK, Sansom MS, Biggin PC, Sattelle DB. A role for Leu118 of loop E in agonist binding to the alpha 7 nicotinic acetylcholine receptor. Molecular Pharmacology. 73: 1659-67. PMID 18339894 DOI: 10.1124/Mol.107.041590 |
0.432 |
|
| 2008 |
Bjerrum EJ, Biggin PC. Rigid body essential X-ray crystallography: distinguishing the bend and twist of glutamate receptor ligand binding domains. Proteins. 72: 434-46. PMID 18214958 DOI: 10.1002/prot.21941 |
0.432 |
|
| 2007 |
Amiri S, Sansom MS, Biggin PC. Molecular dynamics studies of AChBP with nicotine and carbamylcholine: the role of water in the binding pocket. Protein Engineering, Design & Selection : Peds. 20: 353-9. PMID 17595341 DOI: 10.1093/Protein/Gzm029 |
0.427 |
|
| 2007 |
Kaye SL, Sansom MS, Biggin PC. In silico mutation of cysteine residues in the ligand-binding domain of an N-methyl-D-aspartate receptor. Biochemistry. 46: 2136-45. PMID 17269660 DOI: 10.1021/Bi061462D |
0.393 |
|
| 2006 |
Kaye SL, Sansom MS, Biggin PC. Molecular dynamics simulations of the ligand-binding domain of an N-methyl-D-aspartate receptor. The Journal of Biological Chemistry. 281: 12736-42. PMID 16513640 DOI: 10.1074/Jbc.M512728200 |
0.413 |
|
| 2006 |
Arinaminpathy Y, Sansom MS, Biggin PC. Binding site flexibility: molecular simulation of partial and full agonists within a glutamate receptor. Molecular Pharmacology. 69: 11-8. PMID 16219907 DOI: 10.1124/Mol.105.016691 |
0.51 |
|
| 2005 |
Amiri S, Tai K, Beckstein O, Biggin PC, Sansom MS. The alpha7 nicotinic acetylcholine receptor: molecular modelling, electrostatics, and energetics. Molecular Membrane Biology. 22: 151-62. PMID 16096259 DOI: 10.1080/09687860500063340 |
0.347 |
|
| 2005 |
Buckingham SD, Biggin PC, Sattelle BM, Brown LA, Sattelle DB. Insect GABA receptors: splicing, editing, and targeting by antiparasitics and insecticides. Molecular Pharmacology. 68: 942-51. PMID 16027231 DOI: 10.1124/mol.105.015313 |
0.381 |
|
| 2003 |
Beckstein O, Biggin PC, Bond P, Bright JN, Domene C, Grottesi A, Holyoake J, Sansom MS. Ion channel gating: insights via molecular simulations. Febs Letters. 555: 85-90. PMID 14630324 DOI: 10.1016/S0014-5793(03)01151-7 |
0.471 |
|
| 2003 |
Arinaminpathy Y, Biggin PC, Shrivastava IH, Sansom MS. A prokaryotic glutamate receptor: homology modelling and molecular dynamics simulations of GluR0. Febs Letters. 553: 321-7. PMID 14572644 DOI: 10.1016/S0014-5793(03)01036-6 |
0.473 |
|
| 2003 |
Pang A, Arinaminpathy Y, Sansom MS, Biggin PC. Interdomain dynamics and ligand binding: molecular dynamics simulations of glutamine binding protein. Febs Letters. 550: 168-74. PMID 12935905 DOI: 10.1016/S0014-5793(03)00866-4 |
0.38 |
|
| 2003 |
Biggin PC, Sansom MS. Mechanosensitive channels: stress relief. Current Biology : Cb. 13: R183-5. PMID 12620208 DOI: 10.1016/S0960-9822(03)00119-2 |
0.303 |
|
| 2002 |
Sansom MS, Shrivastava IH, Bright JN, Tate J, Capener CE, Biggin PC. Potassium channels: structures, models, simulations. Biochimica Et Biophysica Acta. 1565: 294-307. PMID 12409202 DOI: 10.1016/S0005-2736(02)00576-X |
0.368 |
|
| 2002 |
Biggin PC. Glutamate receptors: desensitizing dimers. Current Biology : Cb. 12: R631-2. PMID 12372271 DOI: 10.1016/S0960-9822(02)01138-7 |
0.522 |
|
| 2002 |
Biggin PC, Sansom MS. Open-state models of a potassium channel. Biophysical Journal. 83: 1867-76. PMID 12324408 DOI: 10.1016/S0006-3495(02)73951-9 |
0.331 |
|
| 2002 |
Sansom MS, Bond P, Beckstein O, Biggin PC, Faraldo-Gómez J, Law RJ, Patargias G, Tieleman DP. Water in ion channels and pores--simulation studies. Novartis Foundation Symposium. 245: 66-78; discussion 79. PMID 12027016 |
0.319 |
|
| 2002 |
Arinaminpathy Y, Sansom MS, Biggin PC. Molecular dynamics simulations of the ligand-binding domain of the ionotropic glutamate receptor GluR2. Biophysical Journal. 82: 676-83. PMID 11806910 DOI: 10.1016/S0006-3495(02)75430-1 |
0.486 |
|
| 2001 |
Tieleman DP, Biggin PC, Smith GR, Sansom MS. Simulation approaches to ion channel structure-function relationships. Quarterly Reviews of Biophysics. 34: 473-561. PMID 11852594 DOI: 10.1017/S0033583501003729 |
0.303 |
|
| 2001 |
Biggin PC, Sansom MS. Channel gating: twist to open. Current Biology : Cb. 11: R364-6. PMID 11369249 DOI: 10.1016/S0960-9822(01)00195-6 |
0.307 |
|
| 2001 |
Beckstein O, Biggin PC, Sansom MSP. A hydrophobic gating mechanism for nanopores Journal of Physical Chemistry B. 105: 12902-12905. DOI: 10.1021/Jp012233Y |
0.321 |
|
| 2000 |
Biggin PC, Roosild T, Choe S. Potassium channel structure: domain by domain. Current Opinion in Structural Biology. 10: 456-61. PMID 10981635 DOI: 10.1016/S0959-440X(00)00114-7 |
0.332 |
|
| 1997 |
Jaikaran DC, Biggin PC, Wenschuh H, Sansom MS, Woolley GA. Structure-function relationships in helix-bundle channels probed via total chemical synthesis of alamethicin dimers: effects of a Gln7 to Asn7 mutation. Biochemistry. 36: 13873-81. PMID 9374865 DOI: 10.1021/Bi9716130 |
0.359 |
|
| 1997 |
Woolley GA, Biggin PC, Schultz A, Lien L, Jaikaran DC, Breed J, Crowhurst K, Sansom MS. Intrinsic rectification of ion flux in alamethicin channels: studies with an alamethicin dimer. Biophysical Journal. 73: 770-8. PMID 9251793 DOI: 10.1016/S0006-3495(97)78109-8 |
0.323 |
|
| 1997 |
Breed J, Biggin PC, Kerr ID, Smart OS, Sansom MS. Alamethicin channels - modelling via restrained molecular dynamics simulations. Biochimica Et Biophysica Acta. 1325: 235-49. PMID 9168149 DOI: 10.1016/S0005-2736(96)00262-3 |
0.304 |
|
| 1997 |
Biggin PC, Breed J, Son HS, Sansom MS. Simulation studies of alamethicin-bilayer interactions. Biophysical Journal. 72: 627-36. PMID 9017192 DOI: 10.1016/S0006-3495(97)78701-0 |
0.324 |
|
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