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Brian C. Kraemer, Ph.D. - Publications

Affiliations: 
University of Wisconsin, Madison, Madison, WI 
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43 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2024 Waldherr SM, Han M, Saxton AD, Vadset TA, McMillan PJ, Wheeler JM, Liachko NF, Kraemer BC. Endoplasmic reticulum unfolded protein response transcriptional targets of XBP-1s mediate rescue from tauopathy. Communications Biology. 7: 903. PMID 39060347 DOI: 10.1038/s42003-024-06570-2  0.34
2023 Kow RL, Black AH, Henderson BP, Kraemer BC. Sut-6/NIPP1 modulates tau toxicity. Human Molecular Genetics. PMID 37000013 DOI: 10.1093/hmg/ddad049  0.382
2023 McMillan PJ, Benbow SJ, Uhrich R, Saxton A, Baum M, Strovas T, Wheeler JM, Baker J, Liachko NF, Keene CD, Latimer CS, Kraemer BC. Tau-RNA complexes inhibit microtubule polymerization and drive disease-relevant conformation change. Brain : a Journal of Neurology. PMID 36732296 DOI: 10.1093/brain/awad032  0.396
2022 Eck RJ, Kow RL, Black AH, Liachko NF, Kraemer BC. SPOP loss of function protects against tauopathy. Proceedings of the National Academy of Sciences of the United States of America. 120: e2207250120. PMID 36574656 DOI: 10.1073/pnas.2207250120  0.333
2022 Kow RL, Black AH, Saxton AD, Liachko NF, Kraemer BC. Loss of aly/ALYREF suppresses toxicity in both tau and TDP-43 models of neurodegeneration. Geroscience. PMID 35122183 DOI: 10.1007/s11357-022-00526-2  0.449
2021 McMillan PJ, Strovas TJ, Baum M, Mitchell BK, Eck RJ, Hendricks N, Wheeler JM, Latimer CS, Keene CD, Kraemer BC. Pathological tau drives ectopic nuclear speckle scaffold protein SRRM2 accumulation in neuron cytoplasm in Alzheimer's disease. Acta Neuropathologica Communications. 9: 117. PMID 34187600 DOI: 10.1186/s40478-021-01219-1  0.442
2020 Kow RL, Strovas TJ, McMillan PJ, Jacobi AM, Behlke MA, Saxton AD, Latimer CS, Keene CD, Kraemer BC. Distinct Poly(A) nucleases have differential impact on sut-2 dependent tauopathy phenotypes. Neurobiology of Disease. 147: 105148. PMID 33184027 DOI: 10.1016/j.nbd.2020.105148  0.386
2020 Baker JD, Uhrich RL, Strovas TJ, Saxton AD, Kraemer BC. AlphaScreen Identifies MSUT2 Inhibitors for Tauopathy-Targeting Therapeutic Discovery. Slas Discovery : Advancing Life Sciences R & D. 2472555220958387. PMID 32981422 DOI: 10.1177/2472555220958387  0.316
2020 Baker JD, Uhrich RL, Strovas TJ, Saxton AD, Kraemer BC. Targeting pathological tau by small molecule inhibition of the poly(A):MSUT2 RNA-protein interaction. Acs Chemical Neuroscience. PMID 32589834 DOI: 10.1021/acschemneuro.0c00214  0.473
2020 Lee EG, Tulloch J, Chen S, Leong L, Saxton AD, Kraemer B, Darvas M, Keene CD, Shutes-David A, Todd K, Millard S, Yu CE. Redefining transcriptional regulation of the APOE gene and its association with Alzheimer's disease. Plos One. 15: e0227667. PMID 31978088 DOI: 10.1371/Journal.Pone.0227667  0.328
2020 Baker JD, Kraemer BC. Inhibition of the MSUT2: RNA interaction for the treatment of tauopathies Alzheimer's & Dementia. 16. DOI: 10.1002/alz.047632  0.318
2019 Wheeler JM, McMillan P, Strovas TJ, Liachko NF, Amlie-Wolf A, Kow RL, Klein RL, Szot P, Robinson L, Guthrie C, Saxton A, Kanaan NM, Raskind M, Peskind E, Trojanowski JQ, ... ... Kraemer B, et al. Activity of the poly(A) binding protein MSUT2 determines susceptibility to pathological tau in the mammalian brain. Science Translational Medicine. 11. PMID 31852801 DOI: 10.1126/Scitranslmed.Aao6545  0.326
2019 Waldherr SM, Strovas TJ, Vadset TA, Liachko NF, Kraemer BC. Constitutive XBP-1s-mediated activation of the endoplasmic reticulum unfolded protein response protects against pathological tau. Nature Communications. 10: 4443. PMID 31570707 DOI: 10.1038/s41467-019-12070-3  0.382
2016 Guerrero EN, Wang H, Mitra J, Hegde PM, Stowell SE, Liachko NF, Kraemer BC, Garruto RM, Rao KS, Hegde ML. TDP-43/FUS in motor neuron disease: Complexity and challenges. Progress in Neurobiology. PMID 27693252 DOI: 10.1016/J.Pneurobio.2016.09.004  0.371
2016 Liachko NF, Saxton AD, McMillan PJ, Strovas TJ, Currey HN, Taylor LM, Wheeler JM, Oblak AL, Ghetti B, Montine TJ, Keene CD, Raskind MA, Bird TD, Kraemer BC. The phosphatase calcineurin regulates pathological TDP-43 phosphorylation. Acta Neuropathologica. PMID 27473149 DOI: 10.1007/S00401-016-1600-Y  0.396
2015 Jablonski AM, Lamitina T, Liachko NF, Sabatella M, Lu J, Zhang L, Ostrow LW, Gupta P, Wu CY, Doshi S, Mojsilovic-Petrovic J, Lans H, Wang J, Kraemer B, Kalb RG. Loss of RAD-23 Protects Against Models of Motor Neuron Disease by Enhancing Mutant Protein Clearance. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 14286-306. PMID 26490867 DOI: 10.1523/Jneurosci.0642-15.2015  0.413
2015 Chen X, McCueF HV, Wong SQ, Kashyap SS, Kraemer BC, Barclay JW, Burgoyne RD, Morgan A. Ethosuximide ameliorates neurodegenerative disease phenotypes by modulating DAF-16/FOXO target gene expression. Molecular Neurodegeneration. 10: 51. PMID 26419537 DOI: 10.1186/S13024-015-0046-3  0.376
2014 Liachko NF, McMillan PJ, Strovas TJ, Loomis E, Greenup L, Murrell JR, Ghetti B, Raskind MA, Montine TJ, Bird TD, Leverenz JB, Kraemer BC. The tau tubulin kinases TTBK1/2 promote accumulation of pathological TDP-43. Plos Genetics. 10: e1004803. PMID 25473830 DOI: 10.1371/Journal.Pgen.1004803  0.348
2014 Salado IG, Redondo M, Bello ML, Perez C, Liachko NF, Kraemer BC, Miguel L, Lecourtois M, Gil C, Martinez A, Perez DI. Protein kinase CK-1 inhibitors as new potential drugs for amyotrophic lateral sclerosis. Journal of Medicinal Chemistry. 57: 2755-72. PMID 24592867 DOI: 10.1021/Jm500065F  0.323
2013 Yu CE, Cudaback E, Foraker J, Thomson Z, Leong L, Lutz F, Gill JA, Saxton A, Kraemer B, Navas P, Keene CD, Montine T, Bekris LM. Epigenetic signature and enhancer activity of the human APOE gene. Human Molecular Genetics. 22: 5036-47. PMID 23892237 DOI: 10.1093/Hmg/Ddt354  0.334
2013 Korvatska O, Strand NS, Berndt JD, Strovas T, Chen DH, Leverenz JB, Kiianitsa K, Mata IF, Karakoc E, Greenup JL, Bonkowski E, Chuang J, Moon RT, Eichler EE, Nickerson DA, ... ... Kraemer BC, et al. Altered splicing of ATP6AP2 causes X-linked parkinsonism with spasticity (XPDS). Human Molecular Genetics. 22: 3259-68. PMID 23595882 DOI: 10.1093/Hmg/Ddt180  0.423
2013 Liachko NF, McMillan PJ, Guthrie CR, Bird TD, Leverenz JB, Kraemer BC. CDC7 inhibition blocks pathological TDP-43 phosphorylation and neurodegeneration. Annals of Neurology. 74: 39-52. PMID 23424178 DOI: 10.1002/Ana.23870  0.33
2013 McCormick AV, Wheeler JM, Guthrie CR, Liachko NF, Kraemer BC. Dopamine D2 receptor antagonism suppresses tau aggregation and neurotoxicity. Biological Psychiatry. 73: 464-71. PMID 23140663 DOI: 10.1016/J.Biopsych.2012.08.027  0.312
2013 Chen X, Kraemer B, Barclay J, Burgoyne R, Morgan A. Using Caenorhabditis elegans to fight human neurodegenerative diseases Molecular Neurodegeneration. 8: P12. DOI: 10.1186/1750-1326-8-S1-P12  0.355
2012 Watkins GR, Wang N, Mazalouskas MD, Gomez RJ, Guthrie CR, Kraemer BC, Schweiger S, Spiller BW, Wadzinski BE. Monoubiquitination promotes calpain cleavage of the protein phosphatase 2A (PP2A) regulatory subunit α4, altering PP2A stability and microtubule-associated protein phosphorylation. The Journal of Biological Chemistry. 287: 24207-15. PMID 22613722 DOI: 10.1074/Jbc.M112.368613  0.405
2012 Lim MA, Selak MA, Xiang Z, Krainc D, Neve RL, Kraemer BC, Watts JL, Kalb RG. Reduced activity of AMP-activated protein kinase protects against genetic models of motor neuron disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 1123-41. PMID 22262909 DOI: 10.1523/Jneurosci.6554-10.2012  0.355
2011 Guthrie CR, Kraemer BC. Proteasome inhibition drives HDAC6-dependent recruitment of tau to aggresomes Journal of Molecular Neuroscience. 45: 32-41. PMID 21340680 DOI: 10.1007/S12031-011-9502-X  0.375
2010 Liachko NF, Guthrie CR, Kraemer BC. Phosphorylation promotes neurotoxicity in a Caenorhabditis elegans model of TDP-43 proteinopathy Journal of Neuroscience. 30: 16208-16219. PMID 21123567 DOI: 10.1523/Jneurosci.2911-10.2010  0.396
2010 Wheeler JM, Guthrie CR, Kraemer BC. The role of MSUT-2 in tau neurotoxicity: A target for neuroprotection in tauopathy? Biochemical Society Transactions. 38: 973-976. PMID 20658987 DOI: 10.1042/Bst0380973  0.325
2010 Kraemer BC, Schuck T, Wheeler JM, Robinson LC, Trojanowski JQ, Lee VM, Schellenberg GD. Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis. Acta Neuropathologica. 119: 409-19. PMID 20198480 DOI: 10.1007/S00401-010-0659-0  0.318
2009 Guthrie CR, Schellenberg GD, Kraemer BC. SUT-2 potentiates tau-induced neurotoxicity in Caenorhabditis elegans. Human Molecular Genetics. 18: 1825-38. PMID 19273536 DOI: 10.1093/Hmg/Ddp099  0.51
2007 Kraemer BC, Schellenberg GD. SUT-1 enables tau-induced neurotoxicity in C. elegans. Human Molecular Genetics. 16: 1959-71. PMID 17576746 DOI: 10.1093/Hmg/Ddm143  0.503
2007 MacMorris M, Kumar M, Lasda E, Larsen A, Kraemer B, Blumenthal T. A novel family of C. elegans snRNPs contains proteins associated with trans-splicing. Rna (New York, N.Y.). 13: 511-20. PMID 17283210 DOI: 10.1261/Rna.426707  0.578
2006 Kraemer BC, Burgess JK, Chen JH, Thomas JH, Schellenberg GD. Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans. Human Molecular Genetics. 15: 1483-96. PMID 16600994 DOI: 10.1093/Hmg/Ddl067  0.375
2006 Kraemer BC, McMillan P, Strovas TC, Keene D, Schellenberg GD, Wheeler JM. P2-171: THE POLY(A) BINDING PROTEIN MSUT2 MODULATES GLIOSIS IN TAUOPATHY Alzheimer's & Dementia. 14: P734-P734. DOI: 10.1016/J.Jalz.2018.06.858  0.316
2003 Kraemer BC, Zhang B, Leverenz JB, Thomas JH, Trojanowski JQ, Schellenberg GD. Neurodegeneration and defective neurotransmission in a Caenorhabditis elegans model of tauopathy. Proceedings of the National Academy of Sciences of the United States of America. 100: 9980-5. PMID 12872001 DOI: 10.1073/Pnas.1533448100  0.311
2002 Eckmann CR, Kraemer B, Wickens M, Kimble J. GLD-3, a bicaudal-C homolog that inhibits FBF to control germline sex determination in C. elegans. Developmental Cell. 3: 697-710. PMID 12431376 DOI: 10.1016/S1534-5807(02)00322-2  0.699
2000 Kraemer B, Zhang B, SenGupta D, Fields S, Wickens M. Using the yeast three-hybrid system to detect and analyze RNA-protein interactions. Methods in Enzymology. 328: 297-321. PMID 11075352 DOI: 10.1016/S0076-6879(00)28404-8  0.708
2000 Luitjens C, Gallegos M, Kraemer B, Kimble J, Wickens M. CPEB proteins control two key steps in spermatogenesis in C. elegans. Genes & Development. 14: 2596-609. PMID 11040214 DOI: 10.1101/Gad.831700  0.425
2000 Zhang B, Kraemer B, SenGupta D, Fields S, Wickens M. Yeast three-hybrid system to detect and analyze RNA-protein interactions. Methods in Enzymology. 318: 399-419. PMID 10890002 DOI: 10.1016/S0076-6879(00)18066-8  0.683
1999 Zhang B, Kraemer B, SenGupta D, Fields S, Wickens M. Yeast three-hybrid system to detect and analyze interactions between RNA and protein. Methods in Enzymology. 306: 93-113. PMID 10432449 DOI: 10.1016/S0076-6879(99)06007-3  0.711
1999 Lee Eg, Yeo A, Kraemer B, Wickens M, Linial ML. The gag domains required for avian retroviral RNA encapsidation determined by using two independent assays. Journal of Virology. 73: 6282-92. PMID 10400719 DOI: 10.1128/Jvi.73.8.6282-6292.1999  0.668
1996 SenGupta DJ, Zhang B, Kraemer B, Pochart P, Fields S, Wickens M. A three-hybrid system to detect RNA-protein interactions in vivo. Proceedings of the National Academy of Sciences of the United States of America. 93: 8496-501. PMID 8710898 DOI: 10.1073/Pnas.93.16.8496  0.717
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