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Virginia Man-Yee Lee, PhD, MBA - Publications

Affiliations: 
Pathology University of Pennsylvania, Philadelphia, PA, United States 
Area:
tau, dementia, neurodegeneration
Website:
http://www.med.upenn.edu/cndr/VMYLeebio.shtml

426 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Chu Y, Muller S, Tavares A, Barret O, Alagille D, Seibyl J, Tamagnan G, Marek K, Luk KC, Trojanowski JQ, Lee VMY, Kordower JH. Intrastriatal alpha-synuclein fibrils in monkeys: spreading, imaging and neuropathological changes. Brain : a Journal of Neurology. PMID 31580415 DOI: 10.1093/brain/awz296  1
2019 Henderson MX, Cornblath EJ, Darwich A, Zhang B, Brown H, Gathagan RJ, Sandler RM, Bassett DS, Trojanowski JQ, Lee VMY. Spread of α-synuclein pathology through the brain connectome is modulated by selective vulnerability and predicted by network analysis. Nature Neuroscience. 22: 1248-1257. PMID 31346295 DOI: 10.1038/s41593-019-0457-5  1
2019 Saito T, Mihira N, Matsuba Y, Sasaguri H, Hashimoto S, Narasimhan S, Zhang B, Murayama S, Higuchi M, Lee VMY, Trojanowski JQ, Saido TC. Humanization of the entire murine gene provides a murine model of pathological human tau propagation. The Journal of Biological Chemistry. PMID 31273083 DOI: 10.1074/jbc.RA119.009487  1
2019 Leyns CEG, Gratuze M, Narasimhan S, Jain N, Koscal LJ, Jiang H, Manis M, Colonna M, Lee VMY, Ulrich JD, Holtzman DM. TREM2 function impedes tau seeding in neuritic plaques. Nature Neuroscience. PMID 31235932 DOI: 10.1038/s41593-019-0433-0  0.4
2019 Henderson MX, Sengupta M, McGeary I, Zhang B, Olufemi MF, Brown H, Trojanowski JQ, Lee VMY. LRRK2 inhibition does not impart protection from α-synuclein pathology and neuron death in non-transgenic mice. Acta Neuropathologica Communications. 7: 28. PMID 30808409 DOI: 10.1186/s40478-019-0679-5  1
2018 Placek K, Baer GM, Elman L, McCluskey L, Hennessy L, Ferraro PM, Lee EB, Lee VMY, Trojanowski JQ, Van Deerlin VM, Grossman M, Irwin DJ, McMillan CT. UNC13A polymorphism contributes to frontotemporal disease in sporadic amyotrophic lateral sclerosis. Neurobiology of Aging. 73: 190-199. PMID 30368160 DOI: 10.1016/j.neurobiolaging.2018.09.031  1
2018 Sandelius Å, Portelius E, Källén Å, Zetterberg H, Rot U, Olsson B, Toledo JB, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, McCluskey L, et al. Elevated CSF GAP-43 is Alzheimer's disease specific and associated with tau and amyloid pathology. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. PMID 30321501 DOI: 10.1016/j.jalz.2018.08.006  1
2018 Gibbons GS, Lee VMY, Trojanowski JQ. Mechanisms of Cell-to-Cell Transmission of Pathological Tau: A Review. Jama Neurology. PMID 30193298 DOI: 10.1001/jamaneurol.2018.2505  1
2018 Martini-Stoica H, Cole AL, Swartzlander DB, Chen F, Wan YW, Bajaj L, Bader DA, Lee VMY, Trojanowski JQ, Liu Z, Sardiello M, Zheng H. TFEB enhances astroglial uptake of extracellular tau species and reduces tau spreading. The Journal of Experimental Medicine. PMID 30108137 DOI: 10.1084/jem.20172158  1
2018 Henderson MX, Peng C, Trojanowski JQ, Lee VMY. LRRK2 activity does not dramatically alter α-synuclein pathology in primary neurons. Acta Neuropathologica Communications. 6: 45. PMID 29855356 DOI: 10.1186/s40478-018-0550-0  1
2018 Portelius E, Olsson B, Höglund K, Cullen NC, Kvartsberg H, Andreasson U, Zetterberg H, Sandelius Å, Shaw LM, Lee VMY, Irwin DJ, Grossman M, Weintraub D, Chen-Plotkin A, Wolk DA, et al. Cerebrospinal fluid neurogranin concentration in neurodegeneration: relation to clinical phenotypes and neuropathology. Acta Neuropathologica. PMID 29700597 DOI: 10.1007/s00401-018-1851-x  1
2018 Luna E, Decker SC, Riddle DM, Caputo A, Zhang B, Cole T, Caswell C, Xie SX, Lee VMY, Luk KC. Differential α-synuclein expression contributes to selective vulnerability of hippocampal neuron subpopulations to fibril-induced toxicity. Acta Neuropathologica. PMID 29502200 DOI: 10.1007/s00401-018-1829-8  1
2018 Gibbons GS, Banks RA, Kim B, Changolkar L, Riddle DM, Leight SN, Irwin DJ, Trojanowski JQ, Lee VMY. Detection of Alzheimer Disease (AD)-Specific Tau Pathology in AD and NonAD Tauopathies by Immunohistochemistry With Novel Conformation-Selective Tau Antibodies. Journal of Neuropathology and Experimental Neurology. PMID 29415231 DOI: 10.1093/jnen/nly010  1
2018 Polinski NK, Volpicelli-Daley LA, Sortwell CE, Luk KC, Cremades N, Gottler LM, Froula J, Duffy MF, Lee VM, Martinez TN, Dave KD. Best Practices for Generating and Using Alpha-Synuclein Pre-Formed Fibrils to Model Parkinson's Disease in Rodents. Journal of Parkinson's Disease. PMID 29400668 DOI: 10.3233/JPD-171248  0.68
2017 Irwin DJ, McMillan CT, Xie SX, Rascovsky K, Van Deerlin VM, Coslett HB, Hamilton R, Aguirre G, Lee EB, Lee VMY, Trojanowski JQ, Grossman M. Asymmetry of post-mortem neuropathology in behavioural-variant frontotemporal dementia. Brain : a Journal of Neurology. PMID 29228211 DOI: 10.1093/brain/awx319  1
2017 Narasimhan S, Guo JL, Changolkar L, Stieber A, McBride JD, Silva LV, He Z, Zhang B, Gathagan RJ, Trojanowski JQ, Lee VMY. Pathological tau strains from human brains recapitulate the diversity of tauopathies in non-transgenic mouse brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29054878 DOI: 10.1523/JNEUROSCI.1230-17.2017  1
2017 Wang J, Han X, Leu NA, Sterling S, Kurosaka S, Fina M, Lee VM, Dong DW, Yates JR, Kashina A. Protein arginylation targets alpha synuclein, facilitates normal brain health, and prevents neurodegeneration. Scientific Reports. 7: 11323. PMID 28900170 DOI: 10.1038/s41598-017-11713-z  0.72
2017 Thakur P, Breger LS, Lundblad M, Wan OW, Mattsson B, Luk KC, Lee VMY, Trojanowski JQ, Björklund A. Modeling Parkinson's disease pathology by combination of fibril seeds and α-synuclein overexpression in the rat brain. Proceedings of the National Academy of Sciences of the United States of America. PMID 28900002 DOI: 10.1073/pnas.1710442114  1
2017 Narasimhan S, Lee VMY. The use of mouse models to study cell-to-cell transmission of pathological tau. Methods in Cell Biology. 141: 287-305. PMID 28882308 DOI: 10.1016/bs.mcb.2017.06.009  0.36
2017 Kovacs GG, Lee VM, Trojanowski JQ. Protein astrogliopathies in human neurodegenerative diseases and aging. Brain Pathology (Zurich, Switzerland). 27: 675-690. PMID 28805003 DOI: 10.1111/bpa.12536  1
2017 Kovacs GG, Yousef A, Kaindl S, Lee VM, Trojanowski JQ. Connexin-43 and Aquaporin-4 are markers of ARTAG-related astroglial response. Neuropathology and Applied Neurobiology. PMID 28755467 DOI: 10.1111/nan.12427  1
2017 McKeith IG, Boeve BF, Dickson DW, Halliday G, Taylor JP, Weintraub D, Aarsland D, Galvin J, Attems J, Ballard CG, Bayston A, Beach TG, Blanc F, Bohnen N, Bonanni L, ... ... Lee VMY, et al. Diagnosis and management of dementia with Lewy bodies: Fourth consensus report of the DLB Consortium. Neurology. PMID 28592453 DOI: 10.1212/WNL.0000000000004058  1
2017 Tapias V, Hu X, Luk KC, Sanders LH, Lee VM, Timothy Greenamyre J. Synthetic alpha-synuclein fibrils cause mitochondrial impairment and selective dopamine neurodegeneration in part via iNOS-mediated nitric oxide production. Cellular and Molecular Life Sciences : Cmls. PMID 28534083 DOI: 10.1007/s00018-017-2541-x  0.68
2017 Henderson MX, Chung CH, Riddle DM, Zhang B, Gathagan RJ, Seeholzer SH, Trojanowski JQ, Lee VMY. Unbiased proteomics of early Lewy body formation model implicates active microtubule affinity-regulating kinases (MARKs) in synucleinopathies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28522732 DOI: 10.1523/JNEUROSCI.2705-16.2017  1
2016 Kovacs GG, Kwong LK, Grossman M, Irwin DJ, Lee EB, Robinson JL, Suh E, Van Deerlin VM, Lee VM, Trojanowski JQ. Tauopathy with hippocampal 4-repeat tau immunoreactive spherical inclusions: a report of three cases. Brain Pathology (Zurich, Switzerland). PMID 28019685 DOI: 10.1111/bpa.12482  1
2016 Hwang AW, Trzeciakiewicz H, Friedmann D, Yuan CX, Marmorstein R, Lee VM, Cohen TJ. Conserved Lysine Acetylation within the Microtubule-Binding Domain Regulates MAP2/Tau Family Members. Plos One. 11: e0168913. PMID 28002468 DOI: 10.1371/journal.pone.0168913  0.64
2016 Crescenzi R, DeBrosse C, Nanga RP, Byrne MD, Krishnamoorthy G, D'Aquilla K, Nath H, Morales KH, Iba M, Hariharan H, Lee VM, Detre JA, Reddy R. Longitudinal imaging reveals sub-hippocampal dynamics in glutamate levels associated with histopathologic events in a mouse model of tauopathy and healthy mice. Hippocampus. PMID 27997993 DOI: 10.1002/hipo.22693  0.76
2016 Guo JL, Narasimhan S, Changolkar L, He Z, Stieber A, Zhang B, Gathagan RJ, Iba M, McBride JD, Trojanowski JQ, Lee VM. Unique pathological tau conformers from Alzheimer's brains transmit tau pathology in nontransgenic mice. The Journal of Experimental Medicine. PMID 27810929 DOI: 10.1084/jem.20160833  1
2016 Makani V, Zhang B, Han H, Yao Y, Lassalas P, Lou K, Paterson I, Lee VM, Trojanowski JQ, Ballatore C, Smith AB, Brunden KR. Evaluation of the brain-penetrant microtubule-stabilizing agent, dictyostatin, in the PS19 tau transgenic mouse model of tauopathy. Acta Neuropathologica Communications. 4: 106. PMID 27687527 DOI: 10.1186/s40478-016-0378-4  1
2016 Guo JL, Buist A, Soares A, Callaerts K, Calafate S, Stevenaert F, Daniels JP, Zoll BE, Crowe A, Brunden KR, Moechars D, Lee VM. The Dynamics and Turnover of Tau Aggregates in Cultured Cells: Insights into Therapies for Tauopathies. The Journal of Biological Chemistry. PMID 27129267 DOI: 10.1074/jbc.M115.712083  0.92
2016 Tuttle MD, Comellas G, Nieuwkoop AJ, Covell DJ, Berthold DA, Kloepper KD, Courtney JM, Kim JK, Barclay AM, Kendall A, Wan W, Stubbs G, Schwieters CD, Lee VM, George JM, et al. Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein. Nature Structural & Molecular Biology. PMID 27018801 DOI: 10.1038/nsmb.3194  0.32
2015 Toledo JB, Gopal P, Raible K, Irwin DJ, Brettschneider J, Sedor S, Waits K, Boluda S, Grossman M, Van Deerlin VM, Lee EB, Arnold SE, Duda JE, Hurtig H, Lee VM, et al. Pathological α-synuclein distribution in subjects with coincident Alzheimer's and Lewy body pathology. Acta Neuropathologica. PMID 26721587 DOI: 10.1007/s00401-015-1526-9  0.52
2015 Haney CM, Wissner RF, Warner JB, Wang YJ, Ferrie JJ, J Covell D, Karpowicz RJ, Lee VM, James Petersson E. Comparison of strategies for non-perturbing labeling of α-synuclein to study amyloidogenesis. Organic & Biomolecular Chemistry. PMID 26695131 DOI: 10.1039/c5ob02329g  0.68
2015 Leung YY, Toledo JB, Nefedov A, Polikar R, Raghavan N, Xie SX, Farnum M, Schultz T, Baek Y, Deerlin VV, Hu WT, Holtzman DM, Fagan AM, Perrin RJ, Grossman M, ... ... Lee VM, et al. Identifying amyloid pathology-related cerebrospinal fluid biomarkers for Alzheimer's disease in a multicohort study. Alzheimer's & Dementia (Amsterdam, Netherlands). 1: 339-348. PMID 26693175 DOI: 10.1016/j.dadm.2015.06.008  1
2015 Irwin DJ, Brettschneider J, McMillan CT, Cooper F, Olm C, Arnold SE, Van Deerlin VM, Seeley WW, Miller BL, Lee EB, Lee VM, Grossman M, Trojanowski JQ. Deep Clinical and Neuropathological Phenotyping of Pick's Disease. Annals of Neurology. PMID 26583316 DOI: 10.1002/ana.24559  0.52
2015 Irwin DJ, Byrne MD, McMillan CT, Cooper F, Arnold SE, Lee EB, Van Deerlin VM, Xie SX, Lee VM, Grossman M, Trojanowski JQ. Semi-Automated Digital Image Analysis of Pick's Disease and TDP-3 Proteinopathy. The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society. PMID 26538548 DOI: 10.1369/0022155415614303  0.68
2015 Amlie-Wolf A, Ryvkin P, Tong R, Dragomir I, Suh E, Xu Y, Van Deerlin VM, Gregory BD, Kwong LK, Trojanowski JQ, Lee VM, Wang LS, Lee EB. Transcriptomic Changes Due to Cytoplasmic TDP-43 Expression Reveal Dysregulation of Histone Transcripts and Nuclear Chromatin. Plos One. 10: e0141836. PMID 26510133 DOI: 10.1371/journal.pone.0141836  0.68
2015 Walker AK, Tripathy K, Restrepo CR, Ge G, Xu Y, Kwong LK, Trojanowski JQ, Lee VM. An insoluble frontotemporal lobar degeneration-associated TDP-43 C-terminal fragment causes neurodegeneration and hippocampus pathology in transgenic mice. Human Molecular Genetics. PMID 26476406 DOI: 10.1093/hmg/ddv424  1
2015 Walker AK, Spiller KJ, Ge G, Zheng A, Xu Y, Zhou M, Tripathy K, Kwong LK, Trojanowski JQ, Lee VM. Functional recovery in new mouse models of ALS/FTLD after clearance of pathological cytoplasmic TDP-43. Acta Neuropathologica. PMID 26197969 DOI: 10.1007/s00401-015-1460-x  1
2015 Iba M, McBride JD, Guo JL, Zhang B, Trojanowski JQ, Lee VM. Tau pathology spread in PS19 tau transgenic mice following locus coeruleus (LC) injections of synthetic tau fibrils is determined by the LC's afferent and efferent connections. Acta Neuropathologica. PMID 26150341 DOI: 10.1007/s00401-015-1458-4  1
2015 Robinson JL, Suh E, Wood EM, Lee EB, Coslett HB, Raible K, Lee VM, Trojanowski JQ, Van Deerlin VM. Common neuropathological features underlie distinct clinical presentations in three siblings with hereditary diffuse leukoencephalopathy with spheroids caused by CSF1R p.Arg782His. Acta Neuropathologica Communications. 3: 42. PMID 26141825 DOI: 10.1186/s40478-015-0219-x  1
2015 Paumier KL, Luk KC, Manfredsson FP, Kanaan NM, Lipton JW, Collier TJ, Steece-Collier K, Kemp CJ, Celano S, Schulz E, Sandoval IM, Fleming S, Dirr E, Polinski NK, Trojanowski JQ, ... Lee VM, et al. Intrastriatal injection of pre-formed mouse α-synuclein fibrils into rats triggers α-synuclein pathology and bilateral nigrostriatal degeneration. Neurobiology of Disease. 82: 185-199. PMID 26093169 DOI: 10.1016/j.nbd.2015.06.003  1
2015 Kouri N, Ross OA, Dombroski B, Younkin CS, Serie DJ, Soto-Ortolaza A, Baker M, Finch NC, Yoon H, Kim J, Fujioka S, McLean CA, Ghetti B, Spina S, Cantwell LB, ... ... Lee VM, et al. Genome-wide association study of corticobasal degeneration identifies risk variants shared with progressive supranuclear palsy. Nature Communications. 6: 7247. PMID 26077951 DOI: 10.1038/ncomms8247  1
2015 Wheeler JM, McMillan PJ, Hawk M, Iba M, Robinson L, Xu GJ, Dombroski BA, Jeong D, Dichter MA, Juul H, Loomis E, Raskind M, Leverenz JB, Trojanowski JQ, Lee VM, et al. High copy wildtype human 1N4R tau expression promotes early pathological tauopathy accompanied by cognitive deficits without progressive neurofibrillary degeneration. Acta Neuropathologica Communications. 3: 33. PMID 26041339 DOI: 10.1186/s40478-015-0210-6  1
2015 Sankaranarayanan S, Barten DM, Vana L, Devidze N, Yang L, Cadelina G, Hoque N, DeCarr L, Keenan S, Lin A, Cao Y, Snyder B, Zhang B, Nitla M, Hirschfeld G, ... ... Lee VM, et al. Passive immunization with phospho-tau antibodies reduces tau pathology and functional deficits in two distinct mouse tauopathy models. Plos One. 10: e0125614. PMID 25933020 DOI: 10.1371/journal.pone.0125614  1
2015 Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Erratum to: Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 129: 929. PMID 25931052 DOI: 10.1007/s00401-015-1428-x  1
2015 Mitsui J, Matsukawa T, Sasaki H, Yabe I, Matsushima M, Dürr A, Brice A, Takashima H, Kikuchi A, Aoki M, Ishiura H, Yasuda T, Date H, Ahsan B, Iwata A, ... ... Lee VM, et al. Variants associated with Gaucher disease in multiple system atrophy. Annals of Clinical and Translational Neurology. 2: 417-26. PMID 25909086 DOI: 10.1002/acn3.185  1
2015 Goossens J, Vanmechelen E, Trojanowski JQ, Lee VM, Van Broeckhoven C, van der Zee J, Engelborghs S. TDP-43 as a possible biomarker for frontotemporal lobar degeneration: a systematic review of existing antibodies. Acta Neuropathologica Communications. 3: 15. PMID 25853864 DOI: 10.1186/s40478-015-0195-1  1
2015 Cornec AS, James MJ, Kovalevich J, Trojanowski JQ, Lee VM, Smith AB, Ballatore C, Brunden KR. Pharmacokinetic, pharmacodynamic and metabolic characterization of a brain retentive microtubule (MT)-stabilizing triazolopyrimidine. Bioorganic & Medicinal Chemistry Letters. PMID 25819095 DOI: 10.1016/j.bmcl.2015.03.002  1
2015 Porta S, Kwong LK, Trojanowski JQ, Lee VM. Drosha inclusions are new components of dipeptide-repeat protein aggregates in FTLD-TDP and ALS C9orf72 expansion cases. Journal of Neuropathology and Experimental Neurology. 74: 380-7. PMID 25756586 DOI: 10.1097/NEN.0000000000000182  1
2015 Brettschneider J, Del Tredici K, Lee VM, Trojanowski JQ. Spreading of pathology in neurodegenerative diseases: a focus on human studies. Nature Reviews. Neuroscience. 16: 109-20. PMID 25588378 DOI: 10.1038/nrn3887  1
2015 Cohen TJ, Hwang AW, Restrepo CR, Yuan CX, Trojanowski JQ, Lee VM. An acetylation switch controls TDP-43 function and aggregation propensity. Nature Communications. 6: 5845. PMID 25556531 DOI: 10.1038/ncomms6845  1
2015 Irwin DJ, Cairns NJ, Grossman M, McMillan CT, Lee EB, Van Deerlin VM, Lee VM, Trojanowski JQ. Frontotemporal lobar degeneration: defining phenotypic diversity through personalized medicine. Acta Neuropathologica. 129: 469-91. PMID 25549971 DOI: 10.1007/s00401-014-1380-1  1
2015 Boluda S, Iba M, Zhang B, Raible KM, Lee VM, Trojanowski JQ. Differential induction and spread of tau pathology in young PS19 tau transgenic mice following intracerebral injections of pathological tau from Alzheimer's disease or corticobasal degeneration brains. Acta Neuropathologica. 129: 221-37. PMID 25534024 DOI: 10.1007/s00401-014-1373-0  1
2015 Peeraer E, Bottelbergs A, Van Kolen K, Stancu IC, Vasconcelos B, Mahieu M, Duytschaever H, Ver Donck L, Torremans A, Sluydts E, Van Acker N, Kemp JA, Mercken M, Brunden KR, Trojanowski JQ, ... ... Lee VM, et al. Intracerebral injection of preformed synthetic tau fibrils initiates widespread tauopathy and neuronal loss in the brains of tau transgenic mice. Neurobiology of Disease. 73: 83-95. PMID 25220759 DOI: 10.1016/j.nbd.2014.08.032  1
2014 Volpicelli-Daley LA, Gamble KL, Schultheiss CE, Riddle DM, West AB, Lee VM. Formation of α-synuclein Lewy neurite-like aggregates in axons impedes the transport of distinct endosomes. Molecular Biology of the Cell. 25: 4010-23. PMID 25298402 DOI: 10.1091/mbc.E14-02-0741  1
2014 Wang X, Liu L, Huang L, Herbst-Robinson K, Cornec AS, James MJ, Sugiyama S, Bassetto M, Brancale A, Trojanowski JQ, Lee VM, Smith AB, Brunden KR, Ballatore C. Potent, long-acting cyclopentane-1,3-Dione thromboxane (A2)-receptor antagonists. Acs Medicinal Chemistry Letters. 5: 1015-20. PMID 25221659 DOI: 10.1021/ml5002085  1
2014 Sieber BA, Landis S, Koroshetz W, Bateman R, Siderowf A, Galpern WR, Dunlop J, Finkbeiner S, Sutherland M, Wang H, Lee VM, Orr HT, Gwinn K, Ludwig K, Taylor A, et al. Prioritized research recommendations from the National Institute of Neurological Disorders and Stroke Parkinson's Disease 2014 conference. Annals of Neurology. 76: 469-72. PMID 25164235 DOI: 10.1002/ana.24261  1
2014 Ballatore C, Gay B, Huang L, Robinson KH, James MJ, Trojanowski JQ, Lee VM, Brunden KR, Smith AB. Evaluation of the cyclopentane-1,2-dione as a potential bio-isostere of the carboxylic acid functional group. Bioorganic & Medicinal Chemistry Letters. 24: 4171-5. PMID 25127105 DOI: 10.1016/j.bmcl.2014.07.047  1
2014 Volpicelli-Daley LA, Luk KC, Lee VM. Addition of exogenous α-synuclein preformed fibrils to primary neuronal cultures to seed recruitment of endogenous α-synuclein to Lewy body and Lewy neurite-like aggregates. Nature Protocols. 9: 2135-46. PMID 25122523 DOI: 10.1038/nprot.2014.143  0.68
2014 McGurk L, Lee VM, Trojanowksi JQ, Van Deerlin VM, Lee EB, Bonini NM. Poly-A binding protein-1 localization to a subset of TDP-43 inclusions in amyotrophic lateral sclerosis occurs more frequently in patients harboring an expansion in C9orf72. Journal of Neuropathology and Experimental Neurology. 73: 837-45. PMID 25111021 DOI: 10.1097/NEN.0000000000000102  1
2014 Yarchoan M, Toledo JB, Lee EB, Arvanitakis Z, Kazi H, Han LY, Louneva N, Lee VM, Kim SF, Trojanowski JQ, Arnold SE. Abnormal serine phosphorylation of insulin receptor substrate 1 is associated with tau pathology in Alzheimer's disease and tauopathies. Acta Neuropathologica. 128: 679-89. PMID 25107476 DOI: 10.1007/s00401-014-1328-5  1
2014 Polito VA, Li H, Martini-Stoica H, Wang B, Yang L, Xu Y, Swartzlander DB, Palmieri M, di Ronza A, Lee VM, Sardiello M, Ballabio A, Zheng H. Selective clearance of aberrant tau proteins and rescue of neurotoxicity by transcription factor EB. Embo Molecular Medicine. 6: 1142-60. PMID 25069841 DOI: 10.15252/emmm.201303671  1
2014 Robinson JL, Molina-Porcel L, Corrada MM, Raible K, Lee EB, Lee VM, Kawas CH, Trojanowski JQ. Perforant path synaptic loss correlates with cognitive impairment and Alzheimer's disease in the oldest-old. Brain : a Journal of Neurology. 137: 2578-87. PMID 25012223 DOI: 10.1093/brain/awu190  1
2014 Crescenzi R, DeBrosse C, Nanga RP, Reddy S, Haris M, Hariharan H, Iba M, Lee VM, Detre JA, Borthakur A, Reddy R. In vivo measurement of glutamate loss is associated with synapse loss in a mouse model of tauopathy. Neuroimage. 101: 185-92. PMID 25003815 DOI: 10.1016/j.neuroimage.2014.06.067  1
2014 Irwin DJ, McMillan CT, Suh E, Powers J, Rascovsky K, Wood EM, Toledo JB, Arnold SE, Lee VM, Van Deerlin VM, Trojanowski JQ, Grossman M. Myelin oligodendrocyte basic protein and prognosis in behavioral-variant frontotemporal dementia. Neurology. 83: 502-9. PMID 24994843 DOI: 10.1212/WNL.0000000000000668  1
2014 Lou K, Yao Y, Hoye AT, James MJ, Cornec AS, Hyde E, Gay B, Lee VM, Trojanowski JQ, Smith AB, Brunden KR, Ballatore C. Brain-penetrant, orally bioavailable microtubule-stabilizing small molecules are potential candidate therapeutics for Alzheimer's disease and related tauopathies. Journal of Medicinal Chemistry. 57: 6116-27. PMID 24992153 DOI: 10.1021/jm5005623  1
2014 Tran HT, Chung CH, Iba M, Zhang B, Trojanowski JQ, Luk KC, Lee VM. Α-synuclein immunotherapy blocks uptake and templated propagation of misfolded α-synuclein and neurodegeneration. Cell Reports. 7: 2054-65. PMID 24931606 DOI: 10.1016/j.celrep.2014.05.033  1
2014 Boluda S, Toledo JB, Irwin DJ, Raible KM, Byrne MD, Lee EB, Lee VM, Trojanowski JQ. A comparison of Aβ amyloid pathology staging systems and correlation with clinical diagnosis. Acta Neuropathologica. 128: 543-50. PMID 24916271 DOI: 10.1007/s00401-014-1308-9  1
2014 Brettschneider J, Arai K, Del Tredici K, Toledo JB, Robinson JL, Lee EB, Kuwabara S, Shibuya K, Irwin DJ, Fang L, Van Deerlin VM, Elman L, McCluskey L, Ludolph AC, Lee VM, et al. TDP-43 pathology and neuronal loss in amyotrophic lateral sclerosis spinal cord. Acta Neuropathologica. 128: 423-37. PMID 24916269 DOI: 10.1007/s00401-014-1299-6  1
2014 McCluskey LF, Geser F, Elman LB, Van Deerlin VM, Robinson JL, Lee VM, Trojanowski JQ. Atypical Alzheimer's disease in an elderly United States resident with amyotrophic lateral sclerosis and pathological tau in spinal motor neurons. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 15: 466-72. PMID 24809433 DOI: 10.3109/21678421.2014.903973  1
2014 Walker AK, Daniels CM, Goldman JE, Trojanowski JQ, Lee VM, Messing A. Astrocytic TDP-43 pathology in Alexander disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 6448-58. PMID 24806671 DOI: 10.1523/JNEUROSCI.0248-14.2014  1
2014 Kwong LK, Irwin DJ, Walker AK, Xu Y, Riddle DM, Trojanowski JQ, Lee VM. Novel monoclonal antibodies to normal and pathologically altered human TDP-43 proteins. Acta Neuropathologica Communications. 2: 33. PMID 24690345 DOI: 10.1186/2051-5960-2-33  0.68
2014 Nuytemans K, Inchausti V, Beecham GW, Wang L, Dickson DW, Trojanowski JQ, Lee VM, Mash DC, Frosch MP, Foroud TM, Honig LS, Montine TJ, Dawson TM, Martin ER, Scott WK, et al. Absence of C9ORF72 expanded or intermediate repeats in autopsy-confirmed Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society. 29: 827-30. PMID 24573903 DOI: 10.1002/mds.25838  1
2014 Guo JL, Lee VM. Cell-to-cell transmission of pathogenic proteins in neurodegenerative diseases. Nature Medicine. 20: 130-8. PMID 24504409 DOI: 10.1038/nm.3457  1
2014 Grossman M, Elman L, McCluskey L, McMillan CT, Boller A, Powers J, Rascovsky K, Hu W, Shaw L, Irwin DJ, Lee VM, Trojanowski JQ. Phosphorylated tau as a candidate biomarker for amyotrophic lateral sclerosis. Jama Neurology. 71: 442-8. PMID 24492862 DOI: 10.1001/jamaneurol.2013.6064  1
2014 Gallagher MD, Suh E, Grossman M, Elman L, McCluskey L, Van Swieten JC, Al-Sarraj S, Neumann M, Gelpi E, Ghetti B, Rohrer JD, Halliday G, Van Broeckhoven C, Seilhean D, Shaw PJ, ... ... Lee VM, et al. TMEM106B is a genetic modifier of frontotemporal lobar degeneration with C9orf72 hexanucleotide repeat expansions. Acta Neuropathologica. 127: 407-18. PMID 24442578 DOI: 10.1007/s00401-013-1239-x  1
2014 Brunden KR, Trojanowski JQ, Smith AB, Lee VM, Ballatore C. Microtubule-stabilizing agents as potential therapeutics for neurodegenerative disease. Bioorganic & Medicinal Chemistry. 22: 5040-9. PMID 24433963 DOI: 10.1016/j.bmc.2013.12.046  0.68
2014 Brettschneider J, Del Tredici K, Irwin DJ, Grossman M, Robinson JL, Toledo JB, Lee EB, Fang L, Van Deerlin VM, Ludolph AC, Lee VM, Braak H, Trojanowski JQ. Sequential distribution of pTDP-43 pathology in behavioral variant frontotemporal dementia (bvFTD). Acta Neuropathologica. 127: 423-39. PMID 24407427 DOI: 10.1007/s00401-013-1238-y  1
2014 Ballatore C, Smith AB, Lee VM, Trojanowski JQ, Brunden KR. Aminothienopyridazines as imaging probes of tau pathology: a patent evaluation of WO2013090497. Expert Opinion On Therapeutic Patents. 24: 355-60. PMID 24387030 DOI: 10.1517/13543776.2014.871526  1
2014 McMillan CT, Toledo JB, Avants BB, Cook PA, Wood EM, Suh E, Irwin DJ, Powers J, Olm C, Elman L, McCluskey L, Schellenberg GD, Lee VM, Trojanowski JQ, Van Deerlin VM, et al. Genetic and neuroanatomic associations in sporadic frontotemporal lobar degeneration. Neurobiology of Aging. 35: 1473-82. PMID 24373676 DOI: 10.1016/j.neurobiolaging.2013.11.029  1
2014 Kim HJ, Raphael AR, LaDow ES, McGurk L, Weber RA, Trojanowski JQ, Lee VM, Finkbeiner S, Gitler AD, Bonini NM. Therapeutic modulation of eIF2α phosphorylation rescues TDP-43 toxicity in amyotrophic lateral sclerosis disease models. Nature Genetics. 46: 152-60. PMID 24336168 DOI: 10.1038/ng.2853  1
2014 Luk KC, Lee VM. Modeling Lewy pathology propagation in Parkinson's disease. Parkinsonism & Related Disorders. 20: S85-7. PMID 24262196 DOI: 10.1016/S1353-8020(13)70022-1  0.68
2014 Toledo JB, Van Deerlin VM, Lee EB, Suh E, Baek Y, Robinson JL, Xie SX, McBride J, Wood EM, Schuck T, Irwin DJ, Gross RG, Hurtig H, McCluskey L, Elman L, ... ... Lee VM, et al. A platform for discovery: The University of Pennsylvania Integrated Neurodegenerative Disease Biobank. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 10: 477-84.e1. PMID 23978324 DOI: 10.1016/j.jalz.2013.06.003  1
2013 Brunden KR, Gardner NM, James MJ, Yao Y, Trojanowski JQ, Lee VM, Paterson I, Ballatore C, Smith AB. MT-Stabilizer, Dictyostatin, Exhibits Prolonged Brain Retention and Activity: Potential Therapeutic Implications. Acs Medicinal Chemistry Letters. 4: 886-9. PMID 24900764 DOI: 10.1021/ml400233e  1
2013 Busch JI, Martinez-Lage M, Ashbridge E, Grossman M, Van Deerlin VM, Hu F, Lee VM, Trojanowski JQ, Chen-Plotkin AS. Expression of TMEM106B, the frontotemporal lobar degeneration-associated protein, in normal and diseased human brain. Acta Neuropathologica Communications. 1: 36. PMID 24252750 DOI: 10.1186/2051-5960-1-36  1
2013 Stutzbach LD, Xie SX, Naj AC, Albin R, Gilman S, Lee VM, Trojanowski JQ, Devlin B, Schellenberg GD. The unfolded protein response is activated in disease-affected brain regions in progressive supranuclear palsy and Alzheimer's disease. Acta Neuropathologica Communications. 1: 31. PMID 24252572 DOI: 10.1186/2051-5960-1-31  1
2013 Braak H, Brettschneider J, Ludolph AC, Lee VM, Trojanowski JQ, Del Tredici K. Amyotrophic lateral sclerosis--a model of corticofugal axonal spread. Nature Reviews. Neurology. 9: 708-14. PMID 24217521 DOI: 10.1038/nrneurol.2013.221  1
2013 Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, et al. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. 79: 1094-108. PMID 24050400 DOI: 10.1016/j.neuron.2013.07.037  0.64
2013 Yarchoan M, Louneva N, Xie SX, Swenson FJ, Hu W, Soares H, Trojanowski JQ, Lee VM, Kling MA, Shaw LM, Chen-Plotkin A, Wolk DA, Arnold SE. Association of plasma C-reactive protein levels with the diagnosis of Alzheimer's disease. Journal of the Neurological Sciences. 333: 9-12. PMID 23978419 DOI: 10.1016/j.jns.2013.05.028  1
2013 Irwin DJ, Lee VM, Trojanowski JQ. Parkinson's disease dementia: convergence of α-synuclein, tau and amyloid-β pathologies. Nature Reviews. Neuroscience. 14: 626-36. PMID 23900411 DOI: 10.1038/nrn3549  1
2013 Irwin DJ, Cohen TJ, Grossman M, Arnold SE, McCarty-Wood E, Van Deerlin VM, Lee VM, Trojanowski JQ. Acetylated tau neuropathology in sporadic and hereditary tauopathies. The American Journal of Pathology. 183: 344-51. PMID 23885714 DOI: 10.1016/j.ajpath.2013.04.025  1
2013 Arnold SE, Toledo JB, Appleby DH, Xie SX, Wang LS, Baek Y, Wolk DA, Lee EB, Miller BL, Lee VM, Trojanowski JQ. Comparative survey of the topographical distribution of signature molecular lesions in major neurodegenerative diseases. The Journal of Comparative Neurology. 521: 4339-55. PMID 23881776 DOI: 10.1002/cne.23430  1
2013 Guo JL, Covell DJ, Daniels JP, Iba M, Stieber A, Zhang B, Riddle DM, Kwong LK, Xu Y, Trojanowski JQ, Lee VM. Distinct α-synuclein strains differentially promote tau inclusions in neurons. Cell. 154: 103-17. PMID 23827677 DOI: 10.1016/j.cell.2013.05.057  1
2013 Dryanovski DI, Guzman JN, Xie Z, Galteri DJ, Volpicelli-Daley LA, Lee VM, Miller RJ, Schumacker PT, Surmeier DJ. Calcium entry and α-synuclein inclusions elevate dendritic mitochondrial oxidant stress in dopaminergic neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 10154-64. PMID 23761910 DOI: 10.1523/JNEUROSCI.5311-12.2013  1
2013 Chahine LM, Qiang J, Ashbridge E, Minger J, Yearout D, Horn S, Colcher A, Hurtig HI, Lee VM, Van Deerlin VM, Leverenz JB, Siderowf AD, Trojanowski JQ, Zabetian CP, Chen-Plotkin A. Clinical and biochemical differences in patients having Parkinson disease with vs without GBA mutations. Jama Neurology. 70: 852-8. PMID 23699752 DOI: 10.1001/jamaneurol.2013.1274  1
2013 Brettschneider J, Del Tredici K, Toledo JB, Robinson JL, Irwin DJ, Grossman M, Suh E, Van Deerlin VM, Wood EM, Baek Y, Kwong L, Lee EB, Elman L, McCluskey L, Fang L, ... ... Lee VM, et al. Stages of pTDP-43 pathology in amyotrophic lateral sclerosis. Annals of Neurology. 74: 20-38. PMID 23686809 DOI: 10.1002/ana.23937  1
2013 Cohen TJ, Friedmann D, Hwang AW, Marmorstein R, Lee VM. The microtubule-associated tau protein has intrinsic acetyltransferase activity. Nature Structural & Molecular Biology. 20: 756-62. PMID 23624859 DOI: 10.1038/nsmb.2555  1
2013 Cruchaga C, Kauwe JS, Harari O, Jin SC, Cai Y, Karch CM, Benitez BA, Jeng AT, Skorupa T, Carrell D, Bertelsen S, Bailey M, McKean D, Shulman JM, De Jager PL, ... ... Lee VM, et al. GWAS of cerebrospinal fluid tau levels identifies risk variants for Alzheimer's disease. Neuron. 78: 256-68. PMID 23562540 DOI: 10.1016/j.neuron.2013.02.026  1
2013 Tanik SA, Schultheiss CE, Volpicelli-Daley LA, Brunden KR, Lee VM. Lewy body-like α-synuclein aggregates resist degradation and impair macroautophagy. The Journal of Biological Chemistry. 288: 15194-210. PMID 23532841 DOI: 10.1074/jbc.M113.457408  1
2013 McMillan CT, Irwin DJ, Avants BB, Powers J, Cook PA, Toledo JB, McCarty Wood E, Van Deerlin VM, Lee VM, Trojanowski JQ, Grossman M. White matter imaging helps dissociate tau from TDP-43 in frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 949-55. PMID 23475817 DOI: 10.1136/jnnp-2012-304418  1
2013 Berlau DJ, Corrada MM, Robinson JL, Geser F, Arnold SE, Lee VM, Kawas CH, Trojanowski JQ. Neocortical β-amyloid area is associated with dementia and APOE in the oldest-old. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 699-705. PMID 23474043 DOI: 10.1016/j.jalz.2012.11.011  1
2013 Qiang JK, Wong YC, Siderowf A, Hurtig HI, Xie SX, Lee VM, Trojanowski JQ, Yearout D, B Leverenz J, Montine TJ, Stern M, Mendick S, Jennings D, Zabetian C, Marek K, et al. Plasma apolipoprotein A1 as a biomarker for Parkinson disease. Annals of Neurology. 74: 119-27. PMID 23447138 DOI: 10.1002/ana.23872  1
2013 Crowe A, James MJ, Lee VM, Smith AB, Trojanowski JQ, Ballatore C, Brunden KR. Aminothienopyridazines and methylene blue affect Tau fibrillization via cysteine oxidation. The Journal of Biological Chemistry. 288: 11024-37. PMID 23443659 DOI: 10.1074/jbc.M112.436006  1
2013 Guo JL, Lee VM. Neurofibrillary tangle-like tau pathology induced by synthetic tau fibrils in primary neurons over-expressing mutant tau. Febs Letters. 587: 717-23. PMID 23395797 DOI: 10.1016/j.febslet.2013.01.051  1
2013 Irwin DJ, Abrams JY, Schonberger LB, Leschek EW, Mills JL, Lee VM, Trojanowski JQ. Evaluation of potential infectivity of Alzheimer and Parkinson disease proteins in recipients of cadaver-derived human growth hormone. Jama Neurology. 70: 462-8. PMID 23380910 DOI: 10.1001/jamaneurol.2013.1933  1
2013 Iba M, Guo JL, McBride JD, Zhang B, Trojanowski JQ, Lee VM. Synthetic tau fibrils mediate transmission of neurofibrillary tangles in a transgenic mouse model of Alzheimer's-like tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 1024-37. PMID 23325240 DOI: 10.1523/JNEUROSCI.2642-12.2013  1
2013 Kling MA, Trojanowski JQ, Wolk DA, Lee VM, Arnold SE. Vascular disease and dementias: paradigm shifts to drive research in new directions. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 9: 76-92. PMID 23183137 DOI: 10.1016/j.jalz.2012.02.007  1
2013 Robinson JL, Geser F, Stieber A, Umoh M, Kwong LK, Van Deerlin VM, Lee VM, Trojanowski JQ. TDP-43 skeins show properties of amyloid in a subset of ALS cases. Acta Neuropathologica. 125: 121-31. PMID 23124365 DOI: 10.1007/s00401-012-1055-8  1
2013 Irwin DJ, McMillan CT, Brettschneider J, Libon DJ, Powers J, Rascovsky K, Toledo JB, Boller A, Bekisz J, Chandrasekaran K, Wood EM, Shaw LM, Woo JH, Cook PA, Wolk DA, ... ... Lee VM, et al. Cognitive decline and reduced survival in C9orf72 expansion frontotemporal degeneration and amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 163-9. PMID 23117491 DOI: 10.1136/jnnp-2012-303507  1
2013 Yoshiyama Y, Lee VM, Trojanowski JQ. Therapeutic strategies for tau mediated neurodegeneration. Journal of Neurology, Neurosurgery, and Psychiatry. 84: 784-95. PMID 23085937 DOI: 10.1136/jnnp-2012-303144  1
2013 Greenamyre JT, Cannon JR, Sanders LH, Tapias V, Bai Q, Volpicelli-Daley L, Lee VM, Burton EA. Synuclein-Mitochondrial Interactions in Substantia Nigra Dopamine Neurons Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. 126-127. DOI: 10.1016/B978-0-12-800044-1.00111-2  1
2013 Meng H, Lee VM. Widespread Expression of Sphingosine Kinases and Sphingosine 1-Phosphate (S1P) Lyase Suggests Diverse Functions in the Vertebrate Nervous System Lysophospholipid Receptors: Signaling and Biochemistry. 419-432. DOI: 10.1002/9781118531426.ch19  0.44
2012 Yarchoan M, Xie SX, Kling MA, Toledo JB, Wolk DA, Lee EB, Van Deerlin V, Lee VM, Trojanowski JQ, Arnold SE. Cerebrovascular atherosclerosis correlates with Alzheimer pathology in neurodegenerative dementias. Brain : a Journal of Neurology. 135: 3749-56. PMID 23204143 DOI: 10.1093/brain/aws271  1
2012 Soper JH, Sugiyama S, Herbst-Robinson K, James MJ, Wang X, Trojanowski JQ, Smith AB, Lee VM, Ballatore C, Brunden KR. Brain-penetrant tetrahydronaphthalene thromboxane A2-prostanoid (TP) receptor antagonists as prototype therapeutics for Alzheimer's disease. Acs Chemical Neuroscience. 3: 928-40. PMID 23173073 DOI: 10.1021/cn3000795  1
2012 Luk KC, Kehm V, Carroll J, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Pathological α-synuclein transmission initiates Parkinson-like neurodegeneration in nontransgenic mice. Science (New York, N.Y.). 338: 949-53. PMID 23161999 DOI: 10.1126/science.1227157  1
2012 Trojanowski JQ, Arnold SE, Karlawish JH, Naylor M, Brunden KR, Lee VM. A model for improving the treatment and care of Alzheimer's disease patients through interdisciplinary research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 564-73. PMID 23102127 DOI: 10.1016/j.jalz.2011.08.005  1
2012 Toledo JB, Toledo E, Weiner MW, Jack CR, Jagust W, Lee VM, Shaw LM, Trojanowski JQ. Cardiovascular risk factors, cortisol, and amyloid-β deposition in Alzheimer's Disease Neuroimaging Initiative. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 483-9. PMID 23102118 DOI: 10.1016/j.jalz.2011.08.008  1
2012 Irwin DJ, White MT, Toledo JB, Xie SX, Robinson JL, Van Deerlin V, Lee VM, Leverenz JB, Montine TJ, Duda JE, Hurtig HI, Trojanowski JQ. Neuropathologic substrates of Parkinson disease dementia. Annals of Neurology. 72: 587-98. PMID 23037886 DOI: 10.1002/ana.23659  1
2012 Ballatore C, Brunden KR, Huryn DM, Trojanowski JQ, Lee VM, Smith AB. Microtubule stabilizing agents as potential treatment for Alzheimer's disease and related neurodegenerative tauopathies. Journal of Medicinal Chemistry. 55: 8979-96. PMID 23020671 DOI: 10.1021/jm301079z  1
2012 Naylor MD, Karlawish JH, Arnold SE, Khachaturian AS, Khachaturian ZS, Lee VM, Baumgart M, Banerjee S, Beck C, Blennow K, Brookmeyer R, Brunden KR, Buckwalter KC, Comer M, Covinsky K, et al. Advancing Alzheimer's disease diagnosis, treatment, and care: recommendations from the Ware Invitational Summit. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 445-52. PMID 22959699 DOI: 10.1016/j.jalz.2012.08.001  1
2012 Chen-Plotkin AS, Unger TL, Gallagher MD, Bill E, Kwong LK, Volpicelli-Daley L, Busch JI, Akle S, Grossman M, Van Deerlin V, Trojanowski JQ, Lee VM. TMEM106B, the risk gene for frontotemporal dementia, is regulated by the microRNA-132/212 cluster and affects progranulin pathways. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 11213-27. PMID 22895706 DOI: 10.1523/JNEUROSCI.0521-12.2012  1
2012 Hu WT, Holtzman DM, Fagan AM, Shaw LM, Perrin R, Arnold SE, Grossman M, Xiong C, Craig-Schapiro R, Clark CM, Pickering E, Kuhn M, Chen Y, Van Deerlin VM, McCluskey L, ... ... Lee VM, et al. Plasma multianalyte profiling in mild cognitive impairment and Alzheimer disease. Neurology. 79: 897-905. PMID 22855860 DOI: 10.1212/WNL.0b013e318266fa70  1
2012 Gensure RH, Foran DJ, Lee VM, Gendel VM, Jabbour SK, Carpizo DR, Nosher JL, Yang L. Evaluation of hepatic tumor response to yttrium-90 radioembolization therapy using texture signatures generated from contrast-enhanced CT images. Academic Radiology. 19: 1201-7. PMID 22841288 DOI: 10.1016/j.acra.2012.04.015  0.32
2012 Arnold SE, Xie SX, Leung YY, Wang LS, Kling MA, Han X, Kim EJ, Wolk DA, Bennett DA, Chen-Plotkin A, Grossman M, Hu W, Lee VM, Mackin RS, Trojanowski JQ, et al. Plasma biomarkers of depressive symptoms in older adults. Translational Psychiatry. 2: e65. PMID 22832727 DOI: 10.1038/tp.2011.63  1
2012 Brunden KR, Ballatore C, Lee VM, Smith AB, Trojanowski JQ. Brain-penetrant microtubule-stabilizing compounds as potential therapeutic agents for tauopathies. Biochemical Society Transactions. 40: 661-6. PMID 22817712 DOI: 10.1042/BST20120010  1
2012 Cooper O, Seo H, Andrabi S, Guardia-Laguarta C, Graziotto J, Sundberg M, McLean JR, Carrillo-Reid L, Xie Z, Osborn T, Hargus G, Deleidi M, Lawson T, Bogetofte H, Perez-Torres E, ... ... Lee VM, et al. Pharmacological rescue of mitochondrial deficits in iPSC-derived neural cells from patients with familial Parkinson's disease. Science Translational Medicine. 4: 141ra90. PMID 22764206 DOI: 10.1126/scitranslmed.3003985  1
2012 Figurski MJ, Waligórska T, Toledo J, Vanderstichele H, Korecka M, Lee VM, Trojanowski JQ, Shaw LM. Improved protocol for measurement of plasma β-amyloid in longitudinal evaluation of Alzheimer's Disease Neuroimaging Initiative study patients. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 8: 250-60. PMID 22748936 DOI: 10.1016/j.jalz.2012.01.001  1
2012 Brettschneider J, Toledo JB, Van Deerlin VM, Elman L, McCluskey L, Lee VM, Trojanowski JQ. Microglial activation correlates with disease progression and upper motor neuron clinical symptoms in amyotrophic lateral sclerosis. Plos One. 7: e39216. PMID 22720079 DOI: 10.1371/journal.pone.0039216  1
2012 Ballatore C, Crowe A, Piscitelli F, James M, Lou K, Rossidivito G, Yao Y, Trojanowski JQ, Lee VM, Brunden KR, Smith AB. Aminothienopyridazine inhibitors of tau aggregation: evaluation of structure-activity relationship leads to selection of candidates with desirable in vivo properties. Bioorganic & Medicinal Chemistry. 20: 4451-61. PMID 22717239 DOI: 10.1016/j.bmc.2012.05.027  1
2012 Koffie RM, Hashimoto T, Tai HC, Kay KR, Serrano-Pozo A, Joyner D, Hou S, Kopeikina KJ, Frosch MP, Lee VM, Holtzman DM, Hyman BT, Spires-Jones TL. Apolipoprotein E4 effects in Alzheimer's disease are mediated by synaptotoxic oligomeric amyloid-β. Brain : a Journal of Neurology. 135: 2155-68. PMID 22637583 DOI: 10.1093/brain/aws127  1
2012 Hurtado DE, Molina-Porcel L, Carroll JC, Macdonald C, Aboagye AK, Trojanowski JQ, Lee VM. Selectively silencing GSK-3 isoforms reduces plaques and tangles in mouse models of Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 7392-402. PMID 22623685 DOI: 10.1523/JNEUROSCI.0889-12.2012  1
2012 Wang LS, Leung YY, Chang SK, Leight S, Knapik-Czajka M, Baek Y, Shaw LM, Lee VM, Trojanowski JQ, Clark CM. Comparison of xMAP and ELISA assays for detecting cerebrospinal fluid biomarkers of Alzheimer's disease. Journal of Alzheimer's Disease : Jad. 31: 439-45. PMID 22571982 DOI: 10.3233/JAD-2012-120082  1
2012 Coppola G, Chinnathambi S, Lee JJ, Dombroski BA, Baker MC, Soto-Ortolaza AI, Lee SE, Klein E, Huang AY, Sears R, Lane JR, Karydas AM, Kenet RO, Biernat J, Wang LS, ... ... Lee VM, et al. Evidence for a role of the rare p.A152T variant in MAPT in increasing the risk for FTD-spectrum and Alzheimer's diseases. Human Molecular Genetics. 21: 3500-12. PMID 22556362 DOI: 10.1093/hmg/dds161  1
2012 Hart MP, Brettschneider J, Lee VM, Trojanowski JQ, Gitler AD. Distinct TDP-43 pathology in ALS patients with ataxin 2 intermediate-length polyQ expansions. Acta Neuropathologica. 124: 221-30. PMID 22526021 DOI: 10.1007/s00401-012-0985-5  1
2012 Toledo JB, Brettschneider J, Grossman M, Arnold SE, Hu WT, Xie SX, Lee VM, Shaw LM, Trojanowski JQ. CSF biomarkers cutoffs: the importance of coincident neuropathological diseases. Acta Neuropathologica. 124: 23-35. PMID 22526019 DOI: 10.1007/s00401-012-0983-7  1
2012 Luk KC, Kehm VM, Zhang B, O'Brien P, Trojanowski JQ, Lee VM. Intracerebral inoculation of pathological α-synuclein initiates a rapidly progressive neurodegenerative α-synucleinopathy in mice. The Journal of Experimental Medicine. 209: 975-86. PMID 22508839 DOI: 10.1084/jem.20112457  1
2012 Irwin DJ, McMillan CT, Toledo JB, Arnold SE, Shaw LM, Wang LS, Van Deerlin V, Lee VM, Trojanowski JQ, Grossman M. Comparison of cerebrospinal fluid levels of tau and Aβ 1-42 in Alzheimer disease and frontotemporal degeneration using 2 analytical platforms. Archives of Neurology. 69: 1018-25. PMID 22490326 DOI: 10.1001/archneurol.2012.26  1
2012 Couthouis J, Hart MP, Erion R, King OD, Diaz Z, Nakaya T, Ibrahim F, Kim HJ, Mojsilovic-Petrovic J, Panossian S, Kim CE, Frackelton EC, Solski JA, Williams KL, Clay-Falcone D, ... ... Lee VM, et al. Evaluating the role of the FUS/TLS-related gene EWSR1 in amyotrophic lateral sclerosis. Human Molecular Genetics. 21: 2899-911. PMID 22454397 DOI: 10.1093/hmg/dds116  1
2012 Brettschneider J, Van Deerlin VM, Robinson JL, Kwong L, Lee EB, Ali YO, Safren N, Monteiro MJ, Toledo JB, Elman L, McCluskey L, Irwin DJ, Grossman M, Molina-Porcel L, Lee VM, et al. Pattern of ubiquilin pathology in ALS and FTLD indicates presence of C9ORF72 hexanucleotide expansion. Acta Neuropathologica. 123: 825-39. PMID 22426854 DOI: 10.1007/s00401-012-0970-z  1
2012 Zhang B, Carroll J, Trojanowski JQ, Yao Y, Iba M, Potuzak JS, Hogan AM, Xie SX, Ballatore C, Smith AB, Lee VM, Brunden KR. The microtubule-stabilizing agent, epothilone D, reduces axonal dysfunction, neurotoxicity, cognitive deficits, and Alzheimer-like pathology in an interventional study with aged tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 3601-11. PMID 22423084 DOI: 10.1523/JNEUROSCI.4922-11.2012  1
2012 Irwin DJ, Cohen TJ, Grossman M, Arnold SE, Xie SX, Lee VM, Trojanowski JQ. Acetylated tau, a novel pathological signature in Alzheimer's disease and other tauopathies. Brain : a Journal of Neurology. 135: 807-18. PMID 22366796 DOI: 10.1093/brain/aws013  1
2012 Wang Y, Shi M, Chung KA, Zabetian CP, Leverenz JB, Berg D, Srulijes K, Trojanowski JQ, Lee VM, Siderowf AD, Hurtig H, Litvan I, Schiess MC, Peskind ER, Masuda M, et al. Phosphorylated α-synuclein in Parkinson's disease. Science Translational Medicine. 4: 121ra20. PMID 22344688 DOI: 10.1126/scitranslmed.3002566  1
2012 Martinez-Lage M, Molina-Porcel L, Falcone D, McCluskey L, Lee VM, Van Deerlin VM, Trojanowski JQ. TDP-43 pathology in a case of hereditary spastic paraplegia with a NIPA1/SPG6 mutation. Acta Neuropathologica. 124: 285-91. PMID 22302102 DOI: 10.1007/s00401-012-0947-y  1
2012 Brettschneider J, Libon DJ, Toledo JB, Xie SX, McCluskey L, Elman L, Geser F, Lee VM, Grossman M, Trojanowski JQ. Microglial activation and TDP-43 pathology correlate with executive dysfunction in amyotrophic lateral sclerosis. Acta Neuropathologica. 123: 395-407. PMID 22210083 DOI: 10.1007/s00401-011-0932-x  1
2012 Cohen TJ, Hwang AW, Unger T, Trojanowski JQ, Lee VM. Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking. The Embo Journal. 31: 1241-52. PMID 22193716 DOI: 10.1038/emboj.2011.471  1
2012 Lee EB, Lee VM, Trojanowski JQ. Gains or losses: molecular mechanisms of TDP43-mediated neurodegeneration. Nature Reviews. Neuroscience. 13: 38-50. PMID 22127299 DOI: 10.1038/nrn3121  1
2011 Lee VM, Brunden KR, Hutton M, Trojanowski JQ. Developing therapeutic approaches to tau, selected kinases, and related neuronal protein targets. Cold Spring Harbor Perspectives in Medicine. 1: a006437. PMID 22229117 DOI: 10.1101/cshperspect.a006437  1
2011 Robinson JL, Geser F, Corrada MM, Berlau DJ, Arnold SE, Lee VM, Kawas CH, Trojanowski JQ. Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old. Brain : a Journal of Neurology. 134: 3708-15. PMID 22120149 DOI: 10.1093/brain/awr308  1
2011 Meng H, Yuan Y, Lee VM. Loss of sphingosine kinase 1/S1P signaling impairs cell growth and survival of neurons and progenitor cells in the developing sensory ganglia. Plos One. 6: e27150. PMID 22096531 DOI: 10.1371/journal.pone.0027150  0.44
2011 Couthouis J, Hart MP, Shorter J, DeJesus-Hernandez M, Erion R, Oristano R, Liu AX, Ramos D, Jethava N, Hosangadi D, Epstein J, Chiang A, Diaz Z, Nakaya T, Ibrahim F, ... ... Lee VM, et al. A yeast functional screen predicts new candidate ALS disease genes. Proceedings of the National Academy of Sciences of the United States of America. 108: 20881-90. PMID 22065782 DOI: 10.1073/pnas.1109434108  1
2011 Volpicelli-Daley LA, Luk KC, Patel TP, Tanik SA, Riddle DM, Stieber A, Meaney DF, Trojanowski JQ, Lee VM. Exogenous α-synuclein fibrils induce Lewy body pathology leading to synaptic dysfunction and neuron death. Neuron. 72: 57-71. PMID 21982369 DOI: 10.1016/j.neuron.2011.08.033  1
2011 Carroll JC, Iba M, Bangasser DA, Valentino RJ, James MJ, Brunden KR, Lee VM, Trojanowski JQ. Chronic stress exacerbates tau pathology, neurodegeneration, and cognitive performance through a corticotropin-releasing factor receptor-dependent mechanism in a transgenic mouse model of tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 14436-49. PMID 21976528 DOI: 10.1523/JNEUROSCI.3836-11.2011  1
2011 Yamada K, Cirrito JR, Stewart FR, Jiang H, Finn MB, Holmes BB, Binder LI, Mandelkow EM, Diamond MI, Lee VM, Holtzman DM. In vivo microdialysis reveals age-dependent decrease of brain interstitial fluid tau levels in P301S human tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 13110-7. PMID 21917794 DOI: 10.1523/JNEUROSCI.2569-11.2011  1
2011 Ballatore C, Soper JH, Piscitelli F, James M, Huang L, Atasoylu O, Huryn DM, Trojanowski JQ, Lee VM, Brunden KR, Smith AB. Cyclopentane-1,3-dione: a novel isostere for the carboxylic acid functional group. Application to the design of potent thromboxane (A2) receptor antagonists. Journal of Medicinal Chemistry. 54: 6969-83. PMID 21863799 DOI: 10.1021/jm200980u  1
2011 Toledo JB, Vanderstichele H, Figurski M, Aisen PS, Petersen RC, Weiner MW, Jack CR, Jagust W, Decarli C, Toga AW, Toledo E, Xie SX, Lee VM, Trojanowski JQ, Shaw LM, et al. Factors affecting Aβ plasma levels and their utility as biomarkers in ADNI. Acta Neuropathologica. 122: 401-13. PMID 21805181 DOI: 10.1007/s00401-011-0861-8  1
2011 Xie SX, Baek Y, Grossman M, Arnold SE, Karlawish J, Siderowf A, Hurtig H, Elman L, McCluskey L, Van Deerlin V, Lee VM, Trojanowski JQ. Building an integrated neurodegenerative disease database at an academic health center. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 7: e84-93. PMID 21784346 DOI: 10.1016/j.jalz.2010.08.233  1
2011 Cohen TJ, Lee VM, Trojanowski JQ. TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies. Trends in Molecular Medicine. 17: 659-67. PMID 21783422 DOI: 10.1016/j.molmed.2011.06.004  1
2011 Lim Y, Kehm VM, Lee EB, Soper JH, Li C, Trojanowski JQ, Lee VM. α-Syn suppression reverses synaptic and memory defects in a mouse model of dementia with Lewy bodies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 10076-87. PMID 21734300 DOI: 10.1523/JNEUROSCI.0618-11.2011  1
2011 Takeuchi H, Iba M, Inoue H, Higuchi M, Takao K, Tsukita K, Karatsu Y, Iwamoto Y, Miyakawa T, Suhara T, Trojanowski JQ, Lee VM, Takahashi R. P301S mutant human tau transgenic mice manifest early symptoms of human tauopathies with dementia and altered sensorimotor gating. Plos One. 6: e21050. PMID 21698260 DOI: 10.1371/journal.pone.0021050  1
2011 Mackenzie IR, Neumann M, Baborie A, Sampathu DM, Du Plessis D, Jaros E, Perry RH, Trojanowski JQ, Mann DM, Lee VM. A harmonized classification system for FTLD-TDP pathology. Acta Neuropathologica. 122: 111-3. PMID 21644037 DOI: 10.1007/s00401-011-0845-8  1
2011 Winton MJ, Lee EB, Sun E, Wong MM, Leight S, Zhang B, Trojanowski JQ, Lee VM. Intraneuronal APP, not free Aβ peptides in 3xTg-AD mice: implications for tau versus Aβ-mediated Alzheimer neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 7691-9. PMID 21613482 DOI: 10.1523/JNEUROSCI.6637-10.2011  1
2011 Takasugi N, Sasaki T, Suzuki K, Osawa S, Isshiki H, Hori Y, Shimada N, Higo T, Yokoshima S, Fukuyama T, Lee VM, Trojanowski JQ, Tomita T, Iwatsubo T. BACE1 activity is modulated by cell-associated sphingosine-1-phosphate. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 6850-7. PMID 21543615 DOI: 10.1523/JNEUROSCI.6467-10.2011  1
2011 Chen-Plotkin AS, Hu WT, Siderowf A, Weintraub D, Goldmann Gross R, Hurtig HI, Xie SX, Arnold SE, Grossman M, Clark CM, Shaw LM, McCluskey L, Elman L, Van Deerlin VM, Lee VM, et al. Plasma epidermal growth factor levels predict cognitive decline in Parkinson disease. Annals of Neurology. 69: 655-63. PMID 21520231 DOI: 10.1002/ana.22271  1
2011 Chen-Plotkin AS, Martinez-Lage M, Sleiman PM, Hu W, Greene R, Wood EM, Bing S, Grossman M, Schellenberg GD, Hatanpaa KJ, Weiner MF, White CL, Brooks WS, Halliday GM, Kril JJ, ... ... Lee VM, et al. Genetic and clinical features of progranulin-associated frontotemporal lobar degeneration. Archives of Neurology. 68: 488-97. PMID 21482928 DOI: 10.1001/archneurol.2011.53  1
2011 Yu Z, Zhu Y, Chen-Plotkin AS, Clay-Falcone D, McCluskey L, Elman L, Kalb RG, Trojanowski JQ, Lee VM, Van Deerlin VM, Gitler AD, Bonini NM. PolyQ repeat expansions in ATXN2 associated with ALS are CAA interrupted repeats. Plos One. 6: e17951. PMID 21479228 DOI: 10.1371/journal.pone.0017951  1
2011 Pesiridis GS, Tripathy K, Tanik S, Trojanowski JQ, Lee VM. A "two-hit" hypothesis for inclusion formation by carboxyl-terminal fragments of TDP-43 protein linked to RNA depletion and impaired microtubule-dependent transport. The Journal of Biological Chemistry. 286: 18845-55. PMID 21454607 DOI: 10.1074/jbc.M111.231118  1
2011 Maeda J, Zhang MR, Okauchi T, Ji B, Ono M, Hattori S, Kumata K, Iwata N, Saido TC, Trojanowski JQ, Lee VM, Staufenbiel M, Tomiyama T, Mori H, Fukumura T, et al. In vivo positron emission tomographic imaging of glial responses to amyloid-beta and tau pathologies in mouse models of Alzheimer's disease and related disorders. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 4720-30. PMID 21430171 DOI: 10.1523/JNEUROSCI.3076-10.2011  1
2011 Cohen TJ, Guo JL, Hurtado DE, Kwong LK, Mills IP, Trojanowski JQ, Lee VM. The acetylation of tau inhibits its function and promotes pathological tau aggregation. Nature Communications. 2: 252. PMID 21427723 DOI: 10.1038/ncomms1255  1
2011 Guo JL, Lee VM. Seeding of normal Tau by pathological Tau conformers drives pathogenesis of Alzheimer-like tangles. The Journal of Biological Chemistry. 286: 15317-31. PMID 21372138 DOI: 10.1074/jbc.M110.209296  1
2011 Ballatore C, Brunden KR, Trojanowski JQ, Lee VM, Smith AB, Huryn DM. Modulation of protein-protein interactions as a therapeutic strategy for the treatment of neurodegenerative tauopathies. Current Topics in Medicinal Chemistry. 11: 317-30. PMID 21320060 DOI: 10.2174/156802611794072605  1
2011 Shaw LM, Vanderstichele H, Knapik-Czajka M, Figurski M, Coart E, Blennow K, Soares H, Simon AJ, Lewczuk P, Dean RA, Siemers E, Potter W, Lee VM, Trojanowski JQ. Qualification of the analytical and clinical performance of CSF biomarker analyses in ADNI. Acta Neuropathologica. 121: 597-609. PMID 21311900 DOI: 10.1007/s00401-011-0808-0  1
2011 Geser F, Stein B, Partain M, Elman LB, McCluskey LF, Xie SX, Van Deerlin VM, Kwong LK, Lee VM, Trojanowski JQ. Motor neuron disease clinically limited to the lower motor neuron is a diffuse TDP-43 proteinopathy. Acta Neuropathologica. 121: 509-17. PMID 21225272 DOI: 10.1007/s00401-011-0797-z  1
2011 Igaz LM, Kwong LK, Lee EB, Chen-Plotkin A, Swanson E, Unger T, Malunda J, Xu Y, Winton MJ, Trojanowski JQ, Lee VM. Dysregulation of the ALS-associated gene TDP-43 leads to neuronal death and degeneration in mice. The Journal of Clinical Investigation. 121: 726-38. PMID 21206091 DOI: 10.1172/JCI44867  1
2011 Brunden KR, Yao Y, Potuzak JS, Ferrer NI, Ballatore C, James MJ, Hogan AM, Trojanowski JQ, Smith AB, Lee VM. The characterization of microtubule-stabilizing drugs as possible therapeutic agents for Alzheimer's disease and related tauopathies. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 63: 341-51. PMID 21163349 DOI: 10.1016/j.phrs.2010.12.002  1
2011 Lin L, Lee VM, Wang Y, Lin JS, Sock E, Wegner M, Lei L. Sox11 regulates survival and axonal growth of embryonic sensory neurons. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 240: 52-64. PMID 21117150 DOI: 10.1002/dvdy.22489  0.44
2011 Vass R, Ashbridge E, Geser F, Hu WT, Grossman M, Clay-Falcone D, Elman L, McCluskey L, Lee VM, Van Deerlin VM, Trojanowski JQ, Chen-Plotkin AS. Risk genotypes at TMEM106B are associated with cognitive impairment in amyotrophic lateral sclerosis. Acta Neuropathologica. 121: 373-80. PMID 21104415 DOI: 10.1007/s00401-010-0782-y  1
2011 Geser F, Malunda JA, Hurtig HI, Duda JE, Wenning GK, Gilman S, Low PA, Lee VM, Trojanowski JQ. TDP-43 pathology occurs infrequently in multiple system atrophy. Neuropathology and Applied Neurobiology. 37: 358-65. PMID 20942898 DOI: 10.1111/j.1365-2990.2010.01136.x  1
2011 Soper JH, Kehm V, Burd CG, Bankaitis VA, Lee VM. Aggregation of α-synuclein in S. cerevisiae is associated with defects in endosomal trafficking and phospholipid biosynthesis. Journal of Molecular Neuroscience : Mn. 43: 391-405. PMID 20890676 DOI: 10.1007/s12031-010-9455-5  1
2010 Hu WT, Chen-Plotkin A, Grossman M, Arnold SE, Clark CM, Shaw LM, McCluskey L, Elman L, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ. Novel CSF biomarkers for frontotemporal lobar degenerations. Neurology. 75: 2079-86. PMID 21048198 DOI: 10.1212/WNL.0b013e318200d78d  1
2010 Brunden KR, Zhang B, Carroll J, Yao Y, Potuzak JS, Hogan AM, Iba M, James MJ, Xie SX, Ballatore C, Smith AB, Lee VM, Trojanowski JQ. Epothilone D improves microtubule density, axonal integrity, and cognition in a transgenic mouse model of tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 13861-6. PMID 20943926 DOI: 10.1523/JNEUROSCI.3059-10.2010  1
2010 Geser F, Robinson JL, Malunda JA, Xie SX, Clark CM, Kwong LK, Moberg PJ, Moore EM, Van Deerlin VM, Lee VM, Arnold SE, Trojanowski JQ. Pathological 43-kDa transactivation response DNA-binding protein in older adults with and without severe mental illness. Archives of Neurology. 67: 1238-50. PMID 20937952 DOI: 10.1001/archneurol.2010.254  1
2010 Hu WT, Wang Z, Lee VM, Trojanowski JQ, Detre JA, Grossman M. Distinct cerebral perfusion patterns in FTLD and AD. Neurology. 75: 881-8. PMID 20819999 DOI: 10.1212/WNL.0b013e3181f11e35  1
2010 Hurtado DE, Molina-Porcel L, Iba M, Aboagye AK, Paul SM, Trojanowski JQ, Lee VM. A{beta} accelerates the spatiotemporal progression of tau pathology and augments tau amyloidosis in an Alzheimer mouse model. The American Journal of Pathology. 177: 1977-88. PMID 20802182 DOI: 10.2353/ajpath.2010.100346  1
2010 Elden AC, Kim HJ, Hart MP, Chen-Plotkin AS, Johnson BS, Fang X, Armakola M, Geser F, Greene R, Lu MM, Padmanabhan A, Clay-Falcone D, McCluskey L, Elman L, Juhr D, ... ... Lee VM, et al. Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS. Nature. 466: 1069-75. PMID 20740007 DOI: 10.1038/nature09320  1
2010 Hu WT, McMillan C, Libon D, Leight S, Forman M, Lee VM, Trojanowski JQ, Grossman M. Multimodal predictors for Alzheimer disease in nonfluent primary progressive aphasia. Neurology. 75: 595-602. PMID 20713948 DOI: 10.1212/WNL.0b013e3181ed9c52  1
2010 Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, Soares H, Trojanowski JQ. Biomarker discovery for Alzheimer's disease, frontotemporal lobar degeneration, and Parkinson's disease. Acta Neuropathologica. 120: 385-99. PMID 20652578 DOI: 10.1007/s00401-010-0723-9  1
2010 Korecka M, Clark CM, Lee VM, Trojanowski JQ, Shaw LM. Simultaneous HPLC-MS-MS quantification of 8-iso-PGF(2alpha) and 8,12-iso-iPF(2alpha) in CSF and brain tissue samples with on-line cleanup. Journal of Chromatography. B, Analytical Technologies in the Biomedical and Life Sciences. 878: 2209-16. PMID 20643588 DOI: 10.1016/j.jchromb.2010.06.029  1
2010 Ritson GP, Custer SK, Freibaum BD, Guinto JB, Geffel D, Moore J, Tang W, Winton MJ, Neumann M, Trojanowski JQ, Lee VM, Forman MS, Taylor JP. TDP-43 mediates degeneration in a novel Drosophila model of disease caused by mutations in VCP/p97. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7729-39. PMID 20519548 DOI: 10.1523/JNEUROSCI.5894-09.2010  1
2010 Trojanowski JQ, Vandeerstichele H, Korecka M, Clark CM, Aisen PS, Petersen RC, Blennow K, Soares H, Simon A, Lewczuk P, Dean R, Siemers E, Potter WZ, Weiner MW, Jack CR, ... ... Lee VM, et al. Update on the biomarker core of the Alzheimer's Disease Neuroimaging Initiative subjects. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 230-8. PMID 20451871 DOI: 10.1016/j.jalz.2010.03.008  1
2010 Arnold SE, Lee EB, Moberg PJ, Stutzbach L, Kazi H, Han LY, Lee VM, Trojanowski JQ. Olfactory epithelium amyloid-beta and paired helical filament-tau pathology in Alzheimer disease. Annals of Neurology. 67: 462-9. PMID 20437581 DOI: 10.1002/ana.21910  1
2010 Garbern JY, Neumann M, Trojanowski JQ, Lee VM, Feldman G, Norris JW, Friez MJ, Schwartz CE, Stevenson R, Sima AA. A mutation affecting the sodium/proton exchanger, SLC9A6, causes mental retardation with tau deposition. Brain : a Journal of Neurology. 133: 1391-402. PMID 20395263 DOI: 10.1093/brain/awq071  1
2010 Ballatore C, Brunden KR, Piscitelli F, James MJ, Crowe A, Yao Y, Hyde E, Trojanowski JQ, Lee VM, Smith AB. Discovery of brain-penetrant, orally bioavailable aminothienopyridazine inhibitors of tau aggregation. Journal of Medicinal Chemistry. 53: 3739-47. PMID 20392114 DOI: 10.1021/jm100138f  1
2010 Uryu K, Haddix T, Robinson J, Nakashima-Yasuda H, Lee VM, Trojanowski JQ. Burden of neurodegenerative diseases in a cohort of medical examiner subjects. Journal of Forensic Sciences. 55: 642-5. PMID 20345790 DOI: 10.1111/j.1556-4029.2010.01347.x  1
2010 Trojanowski JQ, Arnold SE, Karlawish JH, Brunden K, Cary M, Davatzikos C, Detre J, Gaulton G, Grossman M, Hurtig H, Jedrziewski K, McCluskey L, Naylor M, Polsky D, Schellenberg GD, ... ... Lee VM, et al. Design of comprehensive Alzheimer's disease centers to address unmet national needs. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 150-5. PMID 20298979 DOI: 10.1016/j.jalz.2009.11.004  1
2010 Xu S, Brunden KR, Trojanowski JQ, Lee VM. Characterization of tau fibrillization in vitro. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 6: 110-7. PMID 20298971 DOI: 10.1016/j.jalz.2009.06.002  1
2010 Chen-Plotkin AS, Lee VM, Trojanowski JQ. TAR DNA-binding protein 43 in neurodegenerative disease. Nature Reviews. Neurology. 6: 211-20. PMID 20234357 DOI: 10.1038/nrneurol.2010.18  1
2010 Hu WT, Chen-Plotkin A, Arnold SE, Grossman M, Clark CM, Shaw LM, Pickering E, Kuhn M, Chen Y, McCluskey L, Elman L, Karlawish J, Hurtig HI, Siderowf A, Lee VM, et al. Novel CSF biomarkers for Alzheimer's disease and mild cognitive impairment. Acta Neuropathologica. 119: 669-78. PMID 20232070 DOI: 10.1007/s00401-010-0667-0  1
2010 Kraemer BC, Schuck T, Wheeler JM, Robinson LC, Trojanowski JQ, Lee VM, Schellenberg GD. Loss of murine TDP-43 disrupts motor function and plays an essential role in embryogenesis. Acta Neuropathologica. 119: 409-19. PMID 20198480 DOI: 10.1007/s00401-010-0659-0  1
2010 Van Deerlin VM, Sleiman PM, Martinez-Lage M, Chen-Plotkin A, Wang LS, Graff-Radford NR, Dickson DW, Rademakers R, Boeve BF, Grossman M, Arnold SE, Mann DM, Pickering-Brown SM, Seelaar H, Heutink P, ... ... Lee VM, et al. Common variants at 7p21 are associated with frontotemporal lobar degeneration with TDP-43 inclusions. Nature Genetics. 42: 234-9. PMID 20154673 DOI: 10.1038/ng.536  0.88
2010 Yu CE, Bird TD, Bekris LM, Montine TJ, Leverenz JB, Steinbart E, Galloway NM, Feldman H, Woltjer R, Miller CA, Wood EM, Grossman M, McCluskey L, Clark CM, Neumann M, ... ... Lee VM, et al. The spectrum of mutations in progranulin: a collaborative study screening 545 cases of neurodegeneration. Archives of Neurology. 67: 161-70. PMID 20142524 DOI: 10.1001/archneurol.2009.328  1
2010 Geser F, Lee VM, Trojanowski JQ. Amyotrophic lateral sclerosis and frontotemporal lobar degeneration: a spectrum of TDP-43 proteinopathies. Neuropathology : Official Journal of the Japanese Society of Neuropathology. 30: 103-12. PMID 20102519 DOI: 10.1111/j.1440-1789.2009.01091.x  1
2010 Lim Y, Kehm VM, Li C, Trojanowski JQ, Lee VM. Forebrain overexpression of alpha-synuclein leads to early postnatal hippocampal neuron loss and synaptic disruption. Experimental Neurology. 221: 86-97. PMID 19833127 DOI: 10.1016/j.expneurol.2009.10.005  1
2010 Brunden KR, Ballatore C, Crowe A, Smith AB, Lee VM, Trojanowski JQ. Tau-directed drug discovery for Alzheimer's disease and related tauopathies: a focus on tau assembly inhibitors. Experimental Neurology. 223: 304-10. PMID 19744482 DOI: 10.1016/j.expneurol.2009.08.031  1
2010 Chen-Plotkin AS, Xiao J, Geser F, Martinez-Lage M, Grossman M, Unger T, Wood EM, Van Deerlin VM, Trojanowski JQ, Lee VM. Brain progranulin expression in GRN-associated frontotemporal lobar degeneration. Acta Neuropathologica. 119: 111-22. PMID 19649643 DOI: 10.1007/s00401-009-0576-2  1
2009 Lippa CF, Rosso AL, Stutzbach LD, Neumann M, Lee VM, Trojanowski JQ. Transactive response DNA-binding protein 43 burden in familial Alzheimer disease and Down syndrome. Archives of Neurology. 66: 1483-8. PMID 20008652 DOI: 10.1001/archneurol.2009.277  1
2009 Portelius E, Zhang B, Gustavsson MK, Brinkmalm G, Westman-Brinkmalm A, Zetterberg H, Lee VM, Trojanowski JQ, Blennow K. Effects of gamma-secretase inhibition on the amyloid beta isoform pattern in a mouse model of Alzheimer's disease. Neuro-Degenerative Diseases. 6: 258-62. PMID 19955704 DOI: 10.1159/000264639  1
2009 Hu WT, Seelaar H, Josephs KA, Knopman DS, Boeve BF, Sorenson EJ, McCluskey L, Elman L, Schelhaas HJ, Parisi JE, Kuesters B, Lee VM, Trojanowski JQ, Petersen RC, van Swieten JC, et al. Survival profiles of patients with frontotemporal dementia and motor neuron disease. Archives of Neurology. 66: 1359-64. PMID 19901167 DOI: 10.1001/archneurol.2009.253  1
2009 Luk KC, Song C, O'Brien P, Stieber A, Branch JR, Brunden KR, Trojanowski JQ, Lee VM. Exogenous alpha-synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells. Proceedings of the National Academy of Sciences of the United States of America. 106: 20051-6. PMID 19892735 DOI: 10.1073/pnas.0908005106  1
2009 Pesiridis GS, Lee VM, Trojanowski JQ. Mutations in TDP-43 link glycine-rich domain functions to amyotrophic lateral sclerosis. Human Molecular Genetics. 18: R156-62. PMID 19808791 DOI: 10.1093/hmg/ddp303  1
2009 Brunden KR, Trojanowski JQ, Lee VM. Advances in tau-focused drug discovery for Alzheimer's disease and related tauopathies. Nature Reviews. Drug Discovery. 8: 783-93. PMID 19794442 DOI: 10.1038/nrd2959  1
2009 Crowe A, Huang W, Ballatore C, Johnson RL, Hogan AM, Huang R, Wichterman J, McCoy J, Huryn D, Auld DS, Smith AB, Inglese J, Trojanowski JQ, Austin CP, Brunden KR, ... Lee VM, et al. Identification of aminothienopyridazine inhibitors of tau assembly by quantitative high-throughput screening. Biochemistry. 48: 7732-45. PMID 19580328 DOI: 10.1021/bi9006435  1
2009 Li W, Sperry JB, Crowe A, Trojanowski JQ, Smith AB, Lee VM. Inhibition of tau fibrillization by oleocanthal via reaction with the amino groups of tau. Journal of Neurochemistry. 110: 1339-51. PMID 19549281 DOI: 10.1111/j.1471-4159.2009.06224.x  1
2009 Shaw LM, Vanderstichele H, Knapik-Czajka M, Clark CM, Aisen PS, Petersen RC, Blennow K, Soares H, Simon A, Lewczuk P, Dean R, Siemers E, Potter W, Lee VM, Trojanowski JQ, et al. Cerebrospinal fluid biomarker signature in Alzheimer's disease neuroimaging initiative subjects. Annals of Neurology. 65: 403-13. PMID 19296504 DOI: 10.1002/ana.21610  1
2009 Geser F, Martinez-Lage M, Kwong LK, Lee VM, Trojanowski JQ. Amyotrophic lateral sclerosis, frontotemporal dementia and beyond: the TDP-43 diseases. Journal of Neurology. 256: 1205-14. PMID 19271105 DOI: 10.1007/s00415-009-5069-7  1
2009 Shineman DW, Dain AS, Kim ML, Lee VM. Constitutively active Akt inhibits trafficking of amyloid precursor protein and amyloid precursor protein metabolites through feedback inhibition of phosphoinositide 3-kinase. Biochemistry. 48: 3787-94. PMID 19236051 DOI: 10.1021/bi802070j  1
2009 Koffie RM, Meyer-Luehmann M, Hashimoto T, Adams KW, Mielke ML, Garcia-Alloza M, Micheva KD, Smith SJ, Kim ML, Lee VM, Hyman BT, Spires-Jones TL. Oligomeric amyloid beta associates with postsynaptic densities and correlates with excitatory synapse loss near senile plaques. Proceedings of the National Academy of Sciences of the United States of America. 106: 4012-7. PMID 19228947 DOI: 10.1073/pnas.0811698106  1
2009 Geser F, Martinez-Lage M, Robinson J, Uryu K, Neumann M, Brandmeir NJ, Xie SX, Kwong LK, Elman L, McCluskey L, Clark CM, Malunda J, Miller BL, Zimmerman EA, Qian J, ... ... Lee VM, et al. Clinical and pathological continuum of multisystem TDP-43 proteinopathies. Archives of Neurology. 66: 180-9. PMID 19204154 DOI: 10.1001/archneurol.2008.558  1
2009 Igaz LM, Kwong LK, Chen-Plotkin A, Winton MJ, Unger TL, Xu Y, Neumann M, Trojanowski JQ, Lee VM. Expression of TDP-43 C-terminal Fragments in Vitro Recapitulates Pathological Features of TDP-43 Proteinopathies. The Journal of Biological Chemistry. 284: 8516-24. PMID 19164285 DOI: 10.1074/jbc.M809462200  1
2009 Meng H, Lee VM. Differential expression of sphingosine-1-phosphate receptors 1-5 in the developing nervous system. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 238: 487-500. PMID 19161225 DOI: 10.1002/dvdy.21852  0.52
2009 Neumann M, Kwong LK, Lee EB, Kremmer E, Flatley A, Xu Y, Forman MS, Troost D, Kretzschmar HA, Trojanowski JQ, Lee VM. Phosphorylation of S409/410 of TDP-43 is a consistent feature in all sporadic and familial forms of TDP-43 proteinopathies. Acta Neuropathologica. 117: 137-49. PMID 19125255 DOI: 10.1007/s00401-008-0477-9  1
2008 Ji B, Maeda J, Sawada M, Ono M, Okauchi T, Inaji M, Zhang MR, Suzuki K, Ando K, Staufenbiel M, Trojanowski JQ, Lee VM, Higuchi M, Suhara T. Imaging of peripheral benzodiazepine receptor expression as biomarkers of detrimental versus beneficial glial responses in mouse models of Alzheimer's and other CNS pathologies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12255-67. PMID 19020019 DOI: 10.1523/JNEUROSCI.2312-08.2008  1
2008 Kim ML, Zhang B, Mills IP, Milla ME, Brunden KR, Lee VM. Effects of TNFalpha-converting enzyme inhibition on amyloid beta production and APP processing in vitro and in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 12052-61. PMID 19005070 DOI: 10.1523/JNEUROSCI.2913-08.2008  1
2008 Steinacker P, Hendrich C, Sperfeld AD, Jesse S, von Arnim CA, Lehnert S, Pabst A, Uttner I, Tumani H, Lee VM, Trojanowski JQ, Kretzschmar HA, Ludolph A, Neumann M, Otto M. TDP-43 in cerebrospinal fluid of patients with frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Archives of Neurology. 65: 1481-7. PMID 19001167 DOI: 10.1001/archneur.65.11.1481  1
2008 Vuletic S, Li G, Peskind ER, Kennedy H, Marcovina SM, Leverenz JB, Petrie EC, Lee VM, Galasko D, Schellenberg GD, Albers JJ. Apolipoprotein E highly correlates with AbetaPP- and tau-related markers in human cerebrospinal fluid. Journal of Alzheimer's Disease : Jad. 15: 409-17. PMID 18997294  1
2008 Luk KC, Mills IP, Trojanowski JQ, Lee VM. Interactions between Hsp70 and the hydrophobic core of alpha-synuclein inhibit fibril assembly. Biochemistry. 47: 12614-25. PMID 18975920 DOI: 10.1021/bi801475r  1
2008 Ballatore C, Zhang B, Trojanowski JQ, Lee VM, Smith AB. In situ blood-brain barrier permeability of a C-10 paclitaxel carbamate. Bioorganic & Medicinal Chemistry Letters. 18: 6119-21. PMID 18947993 DOI: 10.1016/j.bmcl.2008.10.024  1
2008 Kühnlein P, Sperfeld AD, Vanmassenhove B, Van Deerlin V, Lee VM, Trojanowski JQ, Kretzschmar HA, Ludolph AC, Neumann M. Two German kindreds with familial amyotrophic lateral sclerosis due to TARDBP mutations. Archives of Neurology. 65: 1185-9. PMID 18779421 DOI: 10.1001/archneur.65.9.1185  1
2008 Brunden KR, Trojanowski JQ, Lee VM. Evidence that non-fibrillar tau causes pathology linked to neurodegeneration and behavioral impairments. Journal of Alzheimer's Disease : Jad. 14: 393-9. PMID 18688089  1
2008 Gao HM, Kotzbauer PT, Uryu K, Leight S, Trojanowski JQ, Lee VM. Neuroinflammation and oxidation/nitration of alpha-synuclein linked to dopaminergic neurodegeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 7687-98. PMID 18650345 DOI: 10.1523/JNEUROSCI.0143-07.2008  1
2008 Trojanowski JQ, Hendricks JC, Jedrziewski K, Johnson FB, Michel KE, Hess RS, Cancro MP, Sleeper MM, Pignolo R, Teff KL, Aguirre GD, Lee VM, Lawler DF, Pack AI, Davies PF. Exploring human/animal intersections: converging lines of evidence in comparative models of aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 4: 1-5. PMID 18631944 DOI: 10.1016/j.jalz.2007.09.007  1
2008 Cheung KH, Shineman D, Müller M, Cárdenas C, Mei L, Yang J, Tomita T, Iwatsubo T, Lee VM, Foskett JK. Mechanism of Ca2+ disruption in Alzheimer's disease by presenilin regulation of InsP3 receptor channel gating. Neuron. 58: 871-83. PMID 18579078 DOI: 10.1016/j.neuron.2008.04.015  1
2008 Igaz LM, Kwong LK, Xu Y, Truax AC, Uryu K, Neumann M, Clark CM, Elman LB, Miller BL, Grossman M, McCluskey LF, Trojanowski JQ, Lee VM. Enrichment of C-terminal fragments in TAR DNA-binding protein-43 cytoplasmic inclusions in brain but not in spinal cord of frontotemporal lobar degeneration and amyotrophic lateral sclerosis. The American Journal of Pathology. 173: 182-94. PMID 18535185 DOI: 10.2353/ajpath.2008.080003  1
2008 Uryu K, Nakashima-Yasuda H, Forman MS, Kwong LK, Clark CM, Grossman M, Miller BL, Kretzschmar HA, Lee VM, Trojanowski JQ, Neumann M. Concomitant TAR-DNA-binding protein 43 pathology is present in Alzheimer disease and corticobasal degeneration but not in other tauopathies. Journal of Neuropathology and Experimental Neurology. 67: 555-64. PMID 18520774 DOI: 10.1097/NEN.0b013e31817713b5  1
2008 Winton MJ, Van Deerlin VM, Kwong LK, Yuan W, Wood EM, Yu CE, Schellenberg GD, Rademakers R, Caselli R, Karydas A, Trojanowski JQ, Miller BL, Lee VM. A90V TDP-43 variant results in the aberrant localization of TDP-43 in vitro. Febs Letters. 582: 2252-6. PMID 18505686 DOI: 10.1016/j.febslet.2008.05.024  1
2008 Lee VM, Lwigale PY. Neural crest, sensory neuron, and muscle cultures. Methods in Cell Biology. 87: 115-33. PMID 18485294 DOI: 10.1016/S0091-679X(08)00206-9  0.44
2008 Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM. Cytoskeletal requirements in axonal transport of slow component-b. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 5248-56. PMID 18480281 DOI: 10.1523/JNEUROSCI.0309-08.2008  1
2008 Geser F, Brandmeir NJ, Kwong LK, Martinez-Lage M, Elman L, McCluskey L, Xie SX, Lee VM, Trojanowski JQ. Evidence of multisystem disorder in whole-brain map of pathological TDP-43 in amyotrophic lateral sclerosis. Archives of Neurology. 65: 636-41. PMID 18474740 DOI: 10.1001/archneur.65.5.636  1
2008 Bian H, Van Swieten JC, Leight S, Massimo L, Wood E, Forman M, Moore P, de Koning I, Clark CM, Rosso S, Trojanowski J, Lee VM, Grossman M. CSF biomarkers in frontotemporal lobar degeneration with known pathology. Neurology. 70: 1827-35. PMID 18458217 DOI: 10.1212/01.wnl.0000311445.21321.fc  1
2008 Shineman DW, Zhang B, Leight SN, Pratico D, Lee VM. Thromboxane receptor activation mediates isoprostane-induced increases in amyloid pathology in Tg2576 mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 4785-94. PMID 18448655 DOI: 10.1523/JNEUROSCI.0684-08.2008  1
2008 Lim J, Balastik M, Lee TH, Nakamura K, Liou YC, Sun A, Finn G, Pastorino L, Lee VM, Lu KP. Pin1 has opposite effects on wild-type and P301L tau stability and tauopathy. The Journal of Clinical Investigation. 118: 1877-89. PMID 18431510 DOI: 10.1172/JCI34308  1
2008 Grossman M, Xie SX, Libon DJ, Wang X, Massimo L, Moore P, Vesely L, Berkowitz R, Chatterjee A, Coslett HB, Hurtig HI, Forman MS, Lee VM, Trojanowski JQ. Longitudinal decline in autopsy-defined frontotemporal lobar degeneration. Neurology. 70: 2036-45. PMID 18420483 DOI: 10.1212/01.wnl.0000303816.25065.bc  1
2008 Van Deerlin VM, Leverenz JB, Bekris LM, Bird TD, Yuan W, Elman LB, Clay D, Wood EM, Chen-Plotkin AS, Martinez-Lage M, Steinbart E, McCluskey L, Grossman M, Neumann M, Wu IL, ... ... Lee VM, et al. TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis. The Lancet. Neurology. 7: 409-16. PMID 18396105 DOI: 10.1016/S1474-4422(08)70071-1  1
2008 Winton MJ, Igaz LM, Wong MM, Kwong LK, Trojanowski JQ, Lee VM. Disturbance of nuclear and cytoplasmic TAR DNA-binding protein (TDP-43) induces disease-like redistribution, sequestration, and aggregate formation. The Journal of Biological Chemistry. 283: 13302-9. PMID 18305110 DOI: 10.1074/jbc.M800342200  1
2008 Chen-Plotkin AS, Geser F, Plotkin JB, Clark CM, Kwong LK, Yuan W, Grossman M, Van Deerlin VM, Trojanowski JQ, Lee VM. Variations in the progranulin gene affect global gene expression in frontotemporal lobar degeneration. Human Molecular Genetics. 17: 1349-62. PMID 18223198 DOI: 10.1093/hmg/ddn023  1
2008 Morais VA, Leight S, Pijak DS, Lee VM, Costa J. Cellular localization of Nicastrin affects amyloid beta species production. Febs Letters. 582: 427-33. PMID 18201567 DOI: 10.1016/j.febslet.2008.01.003  0.8
2008 Soper JH, Roy S, Stieber A, Lee E, Wilson RB, Trojanowski JQ, Burd CG, Lee VM. Alpha-synuclein-induced aggregation of cytoplasmic vesicles in Saccharomyces cerevisiae. Molecular Biology of the Cell. 19: 1093-103. PMID 18172022 DOI: 10.1091/mbc.E07-08-0827  1
2008 Kwong LK, Uryu K, Trojanowski JQ, Lee VM. TDP-43 proteinopathies: neurodegenerative protein misfolding diseases without amyloidosis. Neuro-Signals. 16: 41-51. PMID 18097159 DOI: 10.1159/000109758  1
2008 Clark CM, Davatzikos C, Borthakur A, Newberg A, Leight S, Lee VM, Trojanowski JQ. Biomarkers for early detection of Alzheimer pathology. Neuro-Signals. 16: 11-8. PMID 18097155 DOI: 10.1159/000109754  1
2008 Lee EB, Lee VM, Trojanowski JQ, Neumann M. TDP-43 immunoreactivity in anoxic, ischemic and neoplastic lesions of the central nervous system. Acta Neuropathologica. 115: 305-11. PMID 18087705 DOI: 10.1007/s00401-007-0331-5  1
2008 Brandmeir NJ, Geser F, Kwong LK, Zimmerman E, Qian J, Lee VM, Trojanowski JQ. Severe subcortical TDP-43 pathology in sporadic frontotemporal lobar degeneration with motor neuron disease. Acta Neuropathologica. 115: 123-31. PMID 18004574 DOI: 10.1007/s00401-007-0315-5  1
2008 Chen-Plotkin AS, Yuan W, Anderson C, McCarty Wood E, Hurtig HI, Clark CM, Miller BL, Lee VM, Trojanowski JQ, Grossman M, Van Deerlin VM. Corticobasal syndrome and primary progressive aphasia as manifestations of LRRK2 gene mutations. Neurology. 70: 521-7. PMID 17914064 DOI: 10.1212/01.WNL.0000280574.17166.26  1
2008 Geser F, Winton MJ, Kwong LK, Xu Y, Xie SX, Igaz LM, Garruto RM, Perl DP, Galasko D, Lee VM, Trojanowski JQ. Pathological TDP-43 in parkinsonism-dementia complex and amyotrophic lateral sclerosis of Guam. Acta Neuropathologica. 115: 133-45. PMID 17713769 DOI: 10.1007/s00401-007-0257-y  1
2008 Xie SX, Forman MS, Farmer J, Moore P, Wang Y, Wang X, Clark CM, Coslett HB, Chatterjee A, Arnold SE, Rosen H, Karlawish JH, Van Deerlin VM, Lee VM, Trojanowski JQ, et al. Factors associated with survival probability in autopsy-proven frontotemporal lobar degeneration. Journal of Neurology, Neurosurgery, and Psychiatry. 79: 126-9. PMID 17615171 DOI: 10.1136/jnnp.2006.110288  1
2007 Jedrziewski MK, Lee VM, Trojanowski JQ. Physical activity and cognitive health. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 3: 98-108. PMID 18379636 DOI: 10.1016/j.jalz.2007.01.009  1
2007 Grossman M, Libon DJ, Forman MS, Massimo L, Wood E, Moore P, Anderson C, Farmer J, Chatterjee A, Clark CM, Coslett HB, Hurtig HI, Lee VM, Trojanowski JQ. Distinct antemortem profiles in patients with pathologically defined frontotemporal dementia. Archives of Neurology. 64: 1601-9. PMID 17998442 DOI: 10.1001/archneur.64.11.1601  1
2007 Forman MS, Trojanowski JQ, Lee VM. TDP-43: a novel neurodegenerative proteinopathy. Current Opinion in Neurobiology. 17: 548-55. PMID 17936612 DOI: 10.1016/j.conb.2007.08.005  1
2007 Luk KC, Hyde EG, Trojanowski JQ, Lee VM. Sensitive fluorescence polarization technique for rapid screening of alpha-synuclein oligomerization/fibrillization inhibitors. Biochemistry. 46: 12522-9. PMID 17927212 DOI: 10.1021/bi701128c  1
2007 Grossman M, Wood EM, Moore P, Neumann M, Kwong L, Forman MS, Clark CM, McCluskey LF, Miller BL, Lee VM, Trojanowski JQ. TDP-43 pathologic lesions and clinical phenotype in frontotemporal lobar degeneration with ubiquitin-positive inclusions. Archives of Neurology. 64: 1449-54. PMID 17923628 DOI: 10.1001/archneur.64.10.1449  1
2007 Neumann M, Kwong LK, Sampathu DM, Trojanowski JQ, Lee VM. TDP-43 proteinopathy in frontotemporal lobar degeneration and amyotrophic lateral sclerosis: protein misfolding diseases without amyloidosis. Archives of Neurology. 64: 1388-94. PMID 17923623 DOI: 10.1001/archneur.64.10.1388  1
2007 Uryu K, Chen XH, Martinez D, Browne KD, Johnson VE, Graham DI, Lee VM, Trojanowski JQ, Smith DH. Multiple proteins implicated in neurodegenerative diseases accumulate in axons after brain trauma in humans. Experimental Neurology. 208: 185-92. PMID 17826768 DOI: 10.1016/j.expneurol.2007.06.018  1
2007 Van Deerlin VM, Wood EM, Moore P, Yuan W, Forman MS, Clark CM, Neumann M, Kwong LK, Trojanowski JQ, Lee VM, Grossman M. Clinical, genetic, and pathologic characteristics of patients with frontotemporal dementia and progranulin mutations. Archives of Neurology. 64: 1148-53. PMID 17698705 DOI: 10.1001/archneur.64.8.1148  1
2007 Ballatore C, Lee VM, Trojanowski JQ. Tau-mediated neurodegeneration in Alzheimer's disease and related disorders. Nature Reviews. Neuroscience. 8: 663-72. PMID 17684513 DOI: 10.1038/nrn2194  1
2007 Nakashima-Yasuda H, Uryu K, Robinson J, Xie SX, Hurtig H, Duda JE, Arnold SE, Siderowf A, Grossman M, Leverenz JB, Woltjer R, Lopez OL, Hamilton R, Tsuang DW, Galasko D, ... ... Lee VM, et al. Co-morbidity of TDP-43 proteinopathy in Lewy body related diseases. Acta Neuropathologica. 114: 221-9. PMID 17653732 DOI: 10.1007/s00401-007-0261-2  1
2007 Choi SH, Leight SN, Lee VM, Li T, Wong PC, Johnson JA, Saraiva MJ, Sisodia SS. Accelerated Abeta deposition in APPswe/PS1deltaE9 mice with hemizygous deletions of TTR (transthyretin). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 7006-10. PMID 17596449 DOI: 10.1523/JNEUROSCI.1919-07.2007  1
2007 Cairns NJ, Neumann M, Bigio EH, Holm IE, Troost D, Hatanpaa KJ, Foong C, White CL, Schneider JA, Kretzschmar HA, Carter D, Taylor-Reinwald L, Paulsmeyer K, Strider J, Gitcho M, ... ... Lee VM, et al. TDP-43 in familial and sporadic frontotemporal lobar degeneration with ubiquitin inclusions. The American Journal of Pathology. 171: 227-40. PMID 17591968 DOI: 10.2353/ajpath.2007.070182  1
2007 Cairns NJ, Bigio EH, Mackenzie IR, Neumann M, Lee VM, Hatanpaa KJ, White CL, Schneider JA, Grinberg LT, Halliday G, Duyckaerts C, Lowe JS, Holm IE, Tolnay M, Okamoto K, et al. Neuropathologic diagnostic and nosologic criteria for frontotemporal lobar degeneration: consensus of the Consortium for Frontotemporal Lobar Degeneration. Acta Neuropathologica. 114: 5-22. PMID 17579875 DOI: 10.1007/s00401-007-0237-2  1
2007 Kim DY, Carey BW, Wang H, Ingano LA, Binshtok AM, Wertz MH, Pettingell WH, He P, Lee VM, Woolf CJ, Kovacs DM. BACE1 regulates voltage-gated sodium channels and neuronal activity. Nature Cell Biology. 9: 755-64. PMID 17576410 DOI: 10.1038/ncb1602  1
2007 Kwong LK, Neumann M, Sampathu DM, Lee VM, Trojanowski JQ. TDP-43 proteinopathy: the neuropathology underlying major forms of sporadic and familial frontotemporal lobar degeneration and motor neuron disease. Acta Neuropathologica. 114: 63-70. PMID 17492294 DOI: 10.1007/s00401-007-0226-5  1
2007 Ballatore C, Hyde E, Deiches RF, Lee VM, Trojanowski JQ, Huryn D, Smith AB. Paclitaxel C-10 carbamates: potential candidates for the treatment of neurodegenerative tauopathies. Bioorganic & Medicinal Chemistry Letters. 17: 3642-6. PMID 17485207 DOI: 10.1016/j.bmcl.2007.04.058  1
2007 Crowe A, Ballatore C, Hyde E, Trojanowski JQ, Lee VM. High throughput screening for small molecule inhibitors of heparin-induced tau fibril formation. Biochemical and Biophysical Research Communications. 358: 1-6. PMID 17482143 DOI: 10.1016/j.bbrc.2007.03.056  1
2007 Mackenzie IR, Bigio EH, Ince PG, Geser F, Neumann M, Cairns NJ, Kwong LK, Forman MS, Ravits J, Stewart H, Eisen A, McClusky L, Kretzschmar HA, Monoranu CM, Highley JR, ... ... Lee VM, et al. Pathological TDP-43 distinguishes sporadic amyotrophic lateral sclerosis from amyotrophic lateral sclerosis with SOD1 mutations. Annals of Neurology. 61: 427-34. PMID 17469116 DOI: 10.1002/ana.21147  1
2007 Leverenz JB, Yu CE, Montine TJ, Steinbart E, Bekris LM, Zabetian C, Kwong LK, Lee VM, Schellenberg GD, Bird TD. A novel progranulin mutation associated with variable clinical presentation and tau, TDP43 and alpha-synuclein pathology. Brain : a Journal of Neurology. 130: 1360-74. PMID 17439980 DOI: 10.1093/brain/awm069  1
2007 Murray R, Neumann M, Forman MS, Farmer J, Massimo L, Rice A, Miller BL, Johnson JK, Clark CM, Hurtig HI, Gorno-Tempini ML, Lee VM, Trojanowski JQ, Grossman M. Cognitive and motor assessment in autopsy-proven corticobasal degeneration. Neurology. 68: 1274-83. PMID 17438218 DOI: 10.1212/01.wnl.0000259519.78480.c3  1
2007 Neumann M, Igaz LM, Kwong LK, Nakashima-Yasuda H, Kolb SJ, Dreyfuss G, Kretzschmar HA, Trojanowski JQ, Lee VM. Absence of heterogeneous nuclear ribonucleoproteins and survival motor neuron protein in TDP-43 positive inclusions in frontotemporal lobar degeneration. Acta Neuropathologica. 113: 543-8. PMID 17415574 DOI: 10.1007/s00401-007-0221-x  1
2007 Roy S, Winton MJ, Black MM, Trojanowski JQ, Lee VM. Rapid and intermittent cotransport of slow component-b proteins. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3131-8. PMID 17376974 DOI: 10.1523/JNEUROSCI.4999-06.2007  1
2007 Neumann M, Kwong LK, Truax AC, Vanmassenhove B, Kretzschmar HA, Van Deerlin VM, Clark CM, Grossman M, Miller BL, Trojanowski JQ, Lee VM. TDP-43-positive white matter pathology in frontotemporal lobar degeneration with ubiquitin-positive inclusions. Journal of Neuropathology and Experimental Neurology. 66: 177-83. PMID 17356379 DOI: 10.1097/01.jnen.0000248554.45456.58  1
2007 Lippa CF, Duda JE, Grossman M, Hurtig HI, Aarsland D, Boeve BF, Brooks DJ, Dickson DW, Dubois B, Emre M, Fahn S, Farmer JM, Galasko D, Galvin JE, Goetz CG, ... ... Lee VM, et al. DLB and PDD boundary issues: diagnosis, treatment, molecular pathology, and biomarkers. Neurology. 68: 812-9. PMID 17353469 DOI: 10.1212/01.wnl.0000256715.13907.d3  1
2007 Shaw LM, Korecka M, Clark CM, Lee VM, Trojanowski JQ. Biomarkers of neurodegeneration for diagnosis and monitoring therapeutics. Nature Reviews. Drug Discovery. 6: 295-303. PMID 17347655 DOI: 10.1038/nrd2176  1
2007 Forman MS, Mufson EJ, Leurgans S, Pratico D, Joyce S, Leight S, Lee VM, Trojanowski JQ. Cortical biochemistry in MCI and Alzheimer disease: lack of correlation with clinical diagnosis. Neurology. 68: 757-63. PMID 17339583 DOI: 10.1212/01.wnl.0000256373.39415.b1  1
2007 Brito C, Escrevente C, Reis CA, Lee VM, Trojanowski JQ, Costa J. Increased levels of fucosyltransferase IX and carbohydrate Lewis(x) adhesion determinant in human NT2N neurons. Journal of Neuroscience Research. 85: 1260-70. PMID 17335083 DOI: 10.1002/jnr.21230  1
2007 Yoshiyama Y, Higuchi M, Zhang B, Huang SM, Iwata N, Saido TC, Maeda J, Suhara T, Trojanowski JQ, Lee VM. Synapse loss and microglial activation precede tangles in a P301S tauopathy mouse model. Neuron. 53: 337-51. PMID 17270732 DOI: 10.1016/j.neuron.2007.01.010  1
2007 Norris EH, Uryu K, Leight S, Giasson BI, Trojanowski JQ, Lee VM. Pesticide exposure exacerbates alpha-synucleinopathy in an A53T transgenic mouse model. The American Journal of Pathology. 170: 658-66. PMID 17255333 DOI: 10.2353/ajpath.2007.060359  1
2007 Van Deerlin VM, Forman MS, Farmer JM, Grossman M, Joyce S, Crowe A, Trojanowski JQ, Lee VM, Chatterjee A. Biochemical and pathological characterization of frontotemporal dementia due to a Leu266Val mutation in microtubule-associated protein tau in an African American individual. Acta Neuropathologica. 113: 471-9. PMID 17072625 DOI: 10.1007/s00401-006-0155-8  1
2006 Beal MF, Bossy-Wetzel E, Finkbeiner S, Fiskum G, Giasson B, Johnson C, Khachaturian ZS, Lee VM, Nicholls D, Reddy H, Reynolds I, Teplow DB, Thal LJ, Trojanowski JQ, Walsh DM, et al. Common threads in neurodegenerative disorders of aging. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 322-6. PMID 19595906 DOI: 10.1016/j.jalz.2006.08.008  1
2006 Clark CM, Pratico D, Shaw LM, Leight S, Xie SX, Gu A, Lee VM, Trojanowski JQ. Commentary on "Optimal design of clinical trials for drugs designed to slow the course of Alzheimer's disease." Biochemical biomarkers of late-life dementia. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 2: 287-93. PMID 19595902 DOI: 10.1016/j.jalz.2006.05.2347  1
2006 Skovronsky DM, Lee VM, Trojanowski JQ. Neurodegenerative diseases: new concepts of pathogenesis and their therapeutic implications. Annual Review of Pathology. 1: 151-70. PMID 18039111 DOI: 10.1146/annurev.pathol.1.110304.100113  1
2006 Riekse RG, Li G, Petrie EC, Leverenz JB, Vavrek D, Vuletic S, Albers JJ, Montine TJ, Lee VM, Lee M, Seubert P, Galasko D, Schellenberg GD, Hazzard WR, Peskind ER. Effect of statins on Alzheimer's disease biomarkers in cerebrospinal fluid. Journal of Alzheimer's Disease : Jad. 10: 399-406. PMID 17183151  1
2006 Li W, Lee VM. Characterization of two VQIXXK motifs for tau fibrillization in vitro. Biochemistry. 45: 15692-701. PMID 17176091 DOI: 10.1021/bi061422+  1
2006 Borthakur A, Gur T, Wheaton AJ, Corbo M, Trojanowski JQ, Lee VM, Reddy R. In vivo measurement of plaque burden in a mouse model of Alzheimer's disease. Journal of Magnetic Resonance Imaging : Jmri. 24: 1011-7. PMID 17036339 DOI: 10.1002/jmri.20751  1
2006 Neumann M, Sampathu DM, Kwong LK, Truax AC, Micsenyi MC, Chou TT, Bruce J, Schuck T, Grossman M, Clark CM, McCluskey LF, Miller BL, Masliah E, Mackenzie IR, Feldman H, ... ... Lee VM, et al. Ubiquitinated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis. Science (New York, N.Y.). 314: 130-3. PMID 17023659 DOI: 10.1126/science.1134108  1
2006 Lee VM, Trojanowski JQ. Mechanisms of Parkinson's disease linked to pathological alpha-synuclein: new targets for drug discovery. Neuron. 52: 33-8. PMID 17015225 DOI: 10.1016/j.neuron.2006.09.026  1
2006 Sampathu DM, Neumann M, Kwong LK, Chou TT, Micsenyi M, Truax A, Bruce J, Grossman M, Trojanowski JQ, Lee VM. Pathological heterogeneity of frontotemporal lobar degeneration with ubiquitin-positive inclusions delineated by ubiquitin immunohistochemistry and novel monoclonal antibodies. The American Journal of Pathology. 169: 1343-52. PMID 17003490 DOI: 10.2353/ajpath.2006.060438  1
2006 Fan Y, Limprasert P, Murray IV, Smith AC, Lee VM, Trojanowski JQ, Sopher BL, La Spada AR. Beta-synuclein modulates alpha-synuclein neurotoxicity by reducing alpha-synuclein protein expression. Human Molecular Genetics. 15: 3002-11. PMID 16959793 DOI: 10.1093/hmg/ddl242  1
2006 Lee VM, Trojanowski JQ. Progress from Alzheimer's tangles to pathological tau points towards more effective therapies now. Journal of Alzheimer's Disease : Jad. 9: 257-62. PMID 16914864  1
2006 Liu K, Solano I, Mann D, Lemere C, Mercken M, Trojanowski JQ, Lee VM. Characterization of Abeta11-40/42 peptide deposition in Alzheimer's disease and young Down's syndrome brains: implication of N-terminally truncated Abeta species in the pathogenesis of Alzheimer's disease. Acta Neuropathologica. 112: 163-74. PMID 16865398 DOI: 10.1007/s00401-006-0077-5  1
2006 Peskind ER, Li G, Shofer J, Quinn JF, Kaye JA, Clark CM, Farlow MR, DeCarli C, Raskind MA, Schellenberg GD, Lee VM, Galasko DR. Age and apolipoprotein E*4 allele effects on cerebrospinal fluid beta-amyloid 42 in adults with normal cognition. Archives of Neurology. 63: 936-9. PMID 16831961 DOI: 10.1001/archneur.63.7.936  1
2006 Zhukareva V, Joyce S, Schuck T, Van Deerlin V, Hurtig H, Albin R, Gilman S, Chin S, Miller B, Trojanowski JQ, Lee VM. Unexpected abundance of pathological tau in progressive supranuclear palsy white matter. Annals of Neurology. 60: 335-45. PMID 16823854 DOI: 10.1002/ana.20916  1
2006 Goker-Alpan O, Giasson BI, Eblan MJ, Nguyen J, Hurtig HI, Lee VM, Trojanowski JQ, Sidransky E. Glucocerebrosidase mutations are an important risk factor for Lewy body disorders. Neurology. 67: 908-10. PMID 16790605 DOI: 10.1212/01.wnl.0000230215.41296.18  1
2006 Forman MS, Farmer J, Johnson JK, Clark CM, Arnold SE, Coslett HB, Chatterjee A, Hurtig HI, Karlawish JH, Rosen HJ, Van Deerlin V, Lee VM, Miller BL, Trojanowski JQ, Grossman M. Frontotemporal dementia: clinicopathological correlations. Annals of Neurology. 59: 952-62. PMID 16718704 DOI: 10.1002/ana.20873  1
2006 Winton MJ, Joyce S, Zhukareva V, Practico D, Perl DP, Galasko D, Craig U, Trojanowski JQ, Lee VM. Characterization of tau pathologies in gray and white matter of Guam parkinsonism-dementia complex. Acta Neuropathologica. 111: 401-12. PMID 16609851 DOI: 10.1007/s00401-006-0053-0  1
2006 Uryu K, Richter-Landsberg C, Welch W, Sun E, Goldbaum O, Norris EH, Pham CT, Yazawa I, Hilburger K, Micsenyi M, Giasson BI, Bonini NM, Lee VM, Trojanowski JQ. Convergence of heat shock protein 90 with ubiquitin in filamentous alpha-synuclein inclusions of alpha-synucleinopathies. The American Journal of Pathology. 168: 947-61. PMID 16507910 DOI: 10.2353/ajpath.2006.050770  1
2006 Liang TW, Truax AC, Trojanowski JQ, Lee VM, Stern MB, Kotzbauer PT. Partial deficit of pantothenate kinase 2 catalytic activity in a case of tremor-predominant neurodegeneration with brain iron accumulation. Movement Disorders : Official Journal of the Movement Disorder Society. 21: 718-22. PMID 16450344 DOI: 10.1002/mds.20797  1
2006 Dabir DV, Robinson MB, Swanson E, Zhang B, Trojanowski JQ, Lee VM, Forman MS. Impaired glutamate transport in a mouse model of tau pathology in astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 644-54. PMID 16407562 DOI: 10.1523/JNEUROSCI.3861-05.2006  1
2006 Lee EB, Leng LZ, Zhang B, Kwong L, Trojanowski JQ, Abel T, Lee VM. Targeting amyloid-beta peptide (Abeta) oligomers by passive immunization with a conformation-selective monoclonal antibody improves learning and memory in Abeta precursor protein (APP) transgenic mice. The Journal of Biological Chemistry. 281: 4292-9. PMID 16361260 DOI: 10.1074/jbc.M511018200  1
2005 Jedrziewski MK, Lee VM, Trojanowski JQ. Lowering the risk of Alzheimer's disease: evidence-based practices emerge from new research. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 1: 152-60. PMID 19595848 DOI: 10.1016/j.jalz.2005.09.007  1
2005 Trojanowski JQ, Lee VM. Commentary on "Diagnosis of Alzheimer's disease: two decades of progress". Alzheimer's disease research: new opportunities for early diagnosis and drug discovery. Alzheimer's & Dementia : the Journal of the Alzheimer's Association. 1: 119-20. PMID 19595841 DOI: 10.1016/j.jalz.2005.10.004  1
2005 Zhang C, Saatman KE, Royo NC, Soltesz KM, Millard M, Schouten JW, Motta M, Hoover RC, McMillan A, Watson DJ, Lee VM, Trojanowski JQ, McIntosh TK. Delayed transplantation of human neurons following brain injury in rats: a long-term graft survival and behavior study. Journal of Neurotrauma. 22: 1456-74. PMID 16379583 DOI: 10.1089/neu.2005.22.1456  1
2005 Goldman JS, Farmer JM, Wood EM, Johnson JK, Boxer A, Neuhaus J, Lomen-Hoerth C, Wilhelmsen KC, Lee VM, Grossman M, Miller BL. Comparison of family histories in FTLD subtypes and related tauopathies. Neurology. 65: 1817-9. PMID 16344531 DOI: 10.1212/01.wnl.0000187068.92184.63  1
2005 Gilman S, May SJ, Shults CW, Tanner CM, Kukull W, Lee VM, Masliah E, Low P, Sandroni P, Trojanowski JQ, Ozelius L, Foroud T. The North American Multiple System Atrophy Study Group. Journal of Neural Transmission (Vienna, Austria : 1996). 112: 1687-94. PMID 16284910 DOI: 10.1007/s00702-005-0381-6  1
2005 Zhang B, Veasey SC, Wood MA, Leng LZ, Kaminski C, Leight S, Abel T, Lee VM, Trojanowski JQ. Impaired rapid eye movement sleep in the Tg2576 APP murine model of Alzheimer's disease with injury to pedunculopontine cholinergic neurons. The American Journal of Pathology. 167: 1361-9. PMID 16251420 DOI: 10.1016/S0002-9440(10)61223-0  1
2005 Trojanowski JQ, Lee VM. Rous-Whipple Award Lecture. The Alzheimer's brain: finding out what's broken tells us how to fix it. The American Journal of Pathology. 167: 1183-8. PMID 16251403  1
2005 Yoshiyama Y, Uryu K, Higuchi M, Longhi L, Hoover R, Fujimoto S, McIntosh T, Lee VM, Trojanowski JQ. Enhanced neurofibrillary tangle formation, cerebral atrophy, and cognitive deficits induced by repetitive mild brain injury in a transgenic tauopathy mouse model. Journal of Neurotrauma. 22: 1134-41. PMID 16238489 DOI: 10.1089/neu.2005.22.1134  1
2005 McKeith IG, Dickson DW, Lowe J, Emre M, O'Brien JT, Feldman H, Cummings J, Duda JE, Lippa C, Perry EK, Aarsland D, Arai H, Ballard CG, Boeve B, Burn DJ, ... ... Lee VM, et al. Diagnosis and management of dementia with Lewy bodies: third report of the DLB Consortium. Neurology. 65: 1863-72. PMID 16237129 DOI: 10.1212/01.wnl.0000187889.17253.b1  1
2005 Nakashima H, Ishihara T, Suguimoto P, Yokota O, Oshima E, Kugo A, Terada S, Hamamura T, Trojanowski JQ, Lee VM, Kuroda S. Chronic lithium treatment decreases tau lesions by promoting ubiquitination in a mouse model of tauopathies. Acta Neuropathologica. 110: 547-56. PMID 16228182 DOI: 10.1007/s00401-005-1087-4  1
2005 Higuchi M, Zhang B, Forman MS, Yoshiyama Y, Trojanowski JQ, Lee VM. Axonal degeneration induced by targeted expression of mutant human tau in oligodendrocytes of transgenic mice that model glial tauopathies. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 9434-43. PMID 16221853 DOI: 10.1523/JNEUROSCI.2691-05.2005  1
2005 Trojanowski JQ, Lee VM. Pathological tau: a loss of normal function or a gain in toxicity? Nature Neuroscience. 8: 1136-7. PMID 16127446 DOI: 10.1038/nn0905-1136  1
2005 Forman MS, Lee VM, Trojanowski JQ. Nosology of Parkinson's disease: looking for the way out of a quagmire. Neuron. 47: 479-82. PMID 16102530 DOI: 10.1016/j.neuron.2005.07.021  1
2005 Yao Y, Clark CM, Trojanowski JQ, Lee VM, Praticò D. Elevation of 12/15 lipoxygenase products in AD and mild cognitive impairment. Annals of Neurology. 58: 623-6. PMID 16037976 DOI: 10.1002/ana.20558  1
2005 Willer GB, Lee VM, Gregg RG, Link BA. Analysis of the Zebrafish perplexed mutation reveals tissue-specific roles for de novo pyrimidine synthesis during development. Genetics. 170: 1827-37. PMID 15937129 DOI: 10.1534/genetics.105.041608  0.44
2005 Trojanowski JQ, Smith AB, Huryn D, Lee VM. Microtubule-stabilising drugs for therapy of Alzheimer's disease and other neurodegenerative disorders with axonal transport impairments. Expert Opinion On Pharmacotherapy. 6: 683-6. PMID 15934894 DOI: 10.1517/14656566.6.5.683  1
2005 Mishizen-Eberz AJ, Norris EH, Giasson BI, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR. Cleavage of alpha-synuclein by calpain: potential role in degradation of fibrillized and nitrated species of alpha-synuclein. Biochemistry. 44: 7818-29. PMID 15909996 DOI: 10.1021/bi047846q  1
2005 Mott RT, Dickson DW, Trojanowski JQ, Zhukareva V, Lee VM, Forman M, Van Deerlin V, Ervin JF, Wang DS, Schmechel DE, Hulette CM. Neuropathologic, biochemical, and molecular characterization of the frontotemporal dementias. Journal of Neuropathology and Experimental Neurology. 64: 420-8. PMID 15892300  1
2005 Lee EB, Leng LZ, Lee VM, Trojanowski JQ. Meningoencephalitis associated with passive immunization of a transgenic murine model of Alzheimer's amyloidosis. Febs Letters. 579: 2564-8. PMID 15862291 DOI: 10.1016/j.febslet.2005.03.070  1
2005 Grossman M, Farmer J, Leight S, Work M, Moore P, Van Deerlin V, Pratico D, Clark CM, Coslett HB, Chatterjee A, Gee J, Trojanowski JQ, Lee VM. Cerebrospinal fluid profile in frontotemporal dementia and Alzheimer's disease. Annals of Neurology. 57: 721-9. PMID 15852395 DOI: 10.1002/ana.20477  1
2005 Liu CW, Giasson BI, Lewis KA, Lee VM, Demartino GN, Thomas PJ. A precipitating role for truncated alpha-synuclein and the proteasome in alpha-synuclein aggregation: implications for pathogenesis of Parkinson disease. The Journal of Biological Chemistry. 280: 22670-8. PMID 15840579 DOI: 10.1074/jbc.M501508200  1
2005 Norris EH, Giasson BI, Hodara R, Xu S, Trojanowski JQ, Ischiropoulos H, Lee VM. Reversible inhibition of alpha-synuclein fibrillization by dopaminochrome-mediated conformational alterations. The Journal of Biological Chemistry. 280: 21212-9. PMID 15817478 DOI: 10.1074/jbc.M412621200  1
2005 Forman MS, Lal D, Zhang B, Dabir DV, Swanson E, Lee VM, Trojanowski JQ. Transgenic mouse model of tau pathology in astrocytes leading to nervous system degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 3539-50. PMID 15814784 DOI: 10.1523/JNEUROSCI.0081-05.2005  1
2005 Yazawa I, Giasson BI, Sasaki R, Zhang B, Joyce S, Uryu K, Trojanowski JQ, Lee VM. Mouse model of multiple system atrophy alpha-synuclein expression in oligodendrocytes causes glial and neuronal degeneration. Neuron. 45: 847-59. PMID 15797547 DOI: 10.1016/j.neuron.2005.01.032  1
2005 Lazarov O, Robinson J, Tang YP, Hairston IS, Korade-Mirnics Z, Lee VM, Hersh LB, Sapolsky RM, Mirnics K, Sisodia SS. Environmental enrichment reduces Abeta levels and amyloid deposition in transgenic mice. Cell. 120: 701-13. PMID 15766532 DOI: 10.1016/j.cell.2005.01.015  1
2005 Lazarov O, Morfini GA, Lee EB, Farah MH, Szodorai A, DeBoer SR, Koliatsos VE, Kins S, Lee VM, Wong PC, Price DL, Brady ST, Sisodia SS. Axonal transport, amyloid precursor protein, kinesin-1, and the processing apparatus: revisited. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 2386-95. PMID 15745965 DOI: 10.1523/JNEUROSCI.3089-04.2005  1
2005 Easton RM, Cho H, Roovers K, Shineman DW, Mizrahi M, Forman MS, Lee VM, Szabolcs M, de Jong R, Oltersdorf T, Ludwig T, Efstratiadis A, Birnbaum MJ. Role for Akt3/protein kinase Bgamma in attainment of normal brain size. Molecular and Cellular Biology. 25: 1869-78. PMID 15713641 DOI: 10.1128/MCB.25.5.1869-1878.2005  1
2005 Geerts H, Trojanowski JQ, Lee VM. Drug discovery in neurodegenerative diseases. Science of Aging Knowledge Environment : Sage Ke. 2005: pe4. PMID 15703448 DOI: 10.1126/sageke.2005.6.pe4  1
2005 Kotzbauer PT, Truax AC, Trojanowski JQ, Lee VM. Altered neuronal mitochondrial coenzyme A synthesis in neurodegeneration with brain iron accumulation caused by abnormal processing, stability, and catalytic activity of mutant pantothenate kinase 2. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 689-98. PMID 15659606 DOI: 10.1523/JNEUROSCI.4265-04.2005  1
2005 Lee VM, Bronner-Fraser M, Baker CV. Restricted response of mesencephalic neural crest to sympathetic differentiation signals in the trunk. Developmental Biology. 278: 175-92. PMID 15649470 DOI: 10.1016/j.ydbio.2004.10.024  0.44
2005 Roy S, Zhang B, Lee VM, Trojanowski JQ. Axonal transport defects: a common theme in neurodegenerative diseases. Acta Neuropathologica. 109: 5-13. PMID 15645263 DOI: 10.1007/s00401-004-0952-x  1
2005 Lee EB, Zhang B, Liu K, Greenbaum EA, Doms RW, Trojanowski JQ, Lee VM. BACE overexpression alters the subcellular processing of APP and inhibits Abeta deposition in vivo. The Journal of Cell Biology. 168: 291-302. PMID 15642747 DOI: 10.1083/jcb.200407070  1
2005 Zhang B, Maiti A, Shively S, Lakhani F, McDonald-Jones G, Bruce J, Lee EB, Xie SX, Joyce S, Li C, Toleikis PM, Lee VM, Trojanowski JQ. Microtubule-binding drugs offset tau sequestration by stabilizing microtubules and reversing fast axonal transport deficits in a tauopathy model. Proceedings of the National Academy of Sciences of the United States of America. 102: 227-31. PMID 15615853 DOI: 10.1073/pnas.0406361102  1
2005 Lee VM, Kenyon TK, Trojanowski JQ. Transgenic animal models of tauopathies. Biochimica Et Biophysica Acta. 1739: 251-9. PMID 15615643 DOI: 10.1016/j.bbadis.2004.06.014  1
2004 Longhi L, Watson DJ, Saatman KE, Thompson HJ, Zhang C, Fujimoto S, Royo N, Castelbuono D, Raghupathi R, Trojanowski JQ, Lee VM, Wolfe JH, Stocchetti N, McIntosh TK. Ex vivo gene therapy using targeted engraftment of NGF-expressing human NT2N neurons attenuates cognitive deficits following traumatic brain injury in mice. Journal of Neurotrauma. 21: 1723-36. PMID 15684764 DOI: 10.1089/neu.2004.21.1723  1
2004 Popescu A, Lippa CF, Lee VM, Trojanowski JQ. Lewy bodies in the amygdala: increase of alpha-synuclein aggregates in neurodegenerative diseases with tau-based inclusions. Archives of Neurology. 61: 1915-9. PMID 15596612 DOI: 10.1001/archneur.61.12.1915  1
2004 Sung S, Yang H, Uryu K, Lee EB, Zhao L, Shineman D, Trojanowski JQ, Lee VM, Praticò D. Modulation of nuclear factor-kappa B activity by indomethacin influences A beta levels but not A beta precursor protein metabolism in a model of Alzheimer's disease. The American Journal of Pathology. 165: 2197-206. PMID 15579461  1
2004 Forman MS, Trojanowski JQ, Lee VM. Neurodegenerative diseases: a decade of discoveries paves the way for therapeutic breakthroughs. Nature Medicine. 10: 1055-63. PMID 15459709 DOI: 10.1038/nm1113  1
2004 Ohtake H, Limprasert P, Fan Y, Onodera O, Kakita A, Takahashi H, Bonner LT, Tsuang DW, Murray IV, Lee VM, Trojanowski JQ, Ishikawa A, Idezuka J, Murata M, Toda T, et al. Beta-synuclein gene alterations in dementia with Lewy bodies. Neurology. 63: 805-11. PMID 15365127  1
2004 Hodara R, Norris EH, Giasson BI, Mishizen-Eberz AJ, Lynch DR, Lee VM, Ischiropoulos H. Functional consequences of alpha-synuclein tyrosine nitration: diminished binding to lipid vesicles and increased fibril formation. The Journal of Biological Chemistry. 279: 47746-53. PMID 15364911 DOI: 10.1074/jbc.M408906200  1
2004 Kotzbauer PT, Giasson BI, Kravitz AV, Golbe LI, Mark MH, Trojanowski JQ, Lee VM. Fibrillization of alpha-synuclein and tau in familial Parkinson's disease caused by the A53T alpha-synuclein mutation. Experimental Neurology. 187: 279-88. PMID 15144854 DOI: 10.1016/j.expneurol.2004.01.007  1
2004 Zhang B, Higuchi M, Yoshiyama Y, Ishihara T, Forman MS, Martinez D, Joyce S, Trojanowski JQ, Lee VM. Retarded axonal transport of R406W mutant tau in transgenic mice with a neurodegenerative tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4657-67. PMID 15140937 DOI: 10.1523/JNEUROSCI.0797-04.2004  1
2004 Wilson CA, Murphy DD, Giasson BI, Zhang B, Trojanowski JQ, Lee VM. Degradative organelles containing mislocalized alpha-and beta-synuclein proliferate in presenilin-1 null neurons. The Journal of Cell Biology. 165: 335-46. PMID 15123735 DOI: 10.1083/jcb.200403061  1
2004 Norris EH, Giasson BI, Lee VM. Alpha-synuclein: normal function and role in neurodegenerative diseases. Current Topics in Developmental Biology. 60: 17-54. PMID 15094295 DOI: 10.1016/S0070-2153(04)60002-0  1
2004 Lee VM, Giasson BI, Trojanowski JQ. More than just two peas in a pod: common amyloidogenic properties of tau and alpha-synuclein in neurodegenerative diseases. Trends in Neurosciences. 27: 129-34. PMID 15036877 DOI: 10.1016/j.tins.2004.01.007  1
2004 Crystal AS, Morais VA, Fortna RR, Carlin D, Pierson TC, Wilson CA, Lee VM, Doms RW. Presenilin modulates Pen-2 levels posttranslationally by protecting it from proteasomal degradation. Biochemistry. 43: 3555-63. PMID 15035625 DOI: 10.1021/bi0361214  1
2004 Wilhelmsen KC, Forman MS, Rosen HJ, Alving LI, Goldman J, Feiger J, Lee JV, Segall SK, Kramer JH, Lomen-Hoerth C, Rankin KP, Johnson J, Feiler HS, Weiner MW, Lee VM, et al. 17q-linked frontotemporal dementia-amyotrophic lateral sclerosis without tau mutations with tau and alpha-synuclein inclusions. Archives of Neurology. 61: 398-406. PMID 15023818 DOI: 10.1001/archneur.61.3.398  1
2004 Dabir DV, Trojanowski JQ, Richter-Landsberg C, Lee VM, Forman MS. Expression of the small heat-shock protein alphaB-crystallin in tauopathies with glial pathology. The American Journal of Pathology. 164: 155-66. PMID 14695329  1
2004 Fortna RR, Crystal AS, Morais VA, Pijak DS, Lee VM, Doms RW. Membrane topology and nicastrin-enhanced endoproteolysis of APH-1, a component of the gamma-secretase complex. The Journal of Biological Chemistry. 279: 3685-93. PMID 14593096 DOI: 10.1074/jbc.M310505200  1
2003 Kung HF, Kung MP, Zhuang ZP, Hou C, Lee CW, Plössl K, Zhuang B, Skovronsky DM, Lee VM, Trojanowski JQ. Iodinated tracers for imaging amyloid plaques in the brain. Molecular Imaging and Biology : Mib : the Official Publication of the Academy of Molecular Imaging. 5: 418-26. PMID 14667496 DOI: 10.1016/j.mibio.2003.09.003  1
2003 Söderberg L, Zhukareva V, Bogdanovic N, Hashimoto T, Winblad B, Iwatsubo T, Lee VM, Trojanowski JQ, Näslund J. Molecular identification of AMY, an Alzheimer disease amyloid-associated protein. Journal of Neuropathology and Experimental Neurology. 62: 1108-17. PMID 14656069  1
2003 Uryu K, Giasson BI, Longhi L, Martinez D, Murray I, Conte V, Nakamura M, Saatman K, Talbot K, Horiguchi T, McIntosh T, Lee VM, Trojanowski JQ. Age-dependent synuclein pathology following traumatic brain injury in mice. Experimental Neurology. 184: 214-24. PMID 14637093 DOI: 10.1016/S0014-4886(03)00245-0  1
2003 Wilson CA, Doms RW, Lee VM. Distinct presenilin-dependent and presenilin-independent gamma-secretases are responsible for total cellular Abeta production. Journal of Neuroscience Research. 74: 361-9. PMID 14598312 DOI: 10.1002/jnr.10776  1
2003 Giasson BI, Lee VM, Trojanowski JQ. Interactions of amyloidogenic proteins. Neuromolecular Medicine. 4: 49-58. PMID 14528052 DOI: 10.1385/NMM:4:1-2:49  1
2003 Goldbaum O, Oppermann M, Handschuh M, Dabir D, Zhang B, Forman MS, Trojanowski JQ, Lee VM, Richter-Landsberg C. Proteasome inhibition stabilizes tau inclusions in oligodendroglial cells that occur after treatment with okadaic acid. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 8872-80. PMID 14523089  1
2003 Pawlyk AC, Giasson BI, Sampathu DM, Perez FA, Lim KL, Dawson VL, Dawson TM, Palmiter RD, Trojanowski JQ, Lee VM. Novel monoclonal antibodies demonstrate biochemical variation of brain parkin with age. The Journal of Biological Chemistry. 278: 48120-8. PMID 12972409 DOI: 10.1074/jbc.M306889200  1
2003 Crystal AS, Giasson BI, Crowe A, Kung MP, Zhuang ZP, Trojanowski JQ, Lee VM. A comparison of amyloid fibrillogenesis using the novel fluorescent compound K114. Journal of Neurochemistry. 86: 1359-68. PMID 12950445 DOI: 10.1046/j.1471-4159.2003.01949.x  1
2003 Horiguchi T, Uryu K, Giasson BI, Ischiropoulos H, LightFoot R, Bellmann C, Richter-Landsberg C, Lee VM, Trojanowski JQ. Nitration of tau protein is linked to neurodegeneration in tauopathies. The American Journal of Pathology. 163: 1021-31. PMID 12937143 DOI: 10.1016/S0002-9440(10)63462-1  1
2003 Morais VA, Crystal AS, Pijak DS, Carlin D, Costa J, Lee VM, Doms RW. The transmembrane domain region of nicastrin mediates direct interactions with APH-1 and the gamma-secretase complex. The Journal of Biological Chemistry. 278: 43284-91. PMID 12917438 DOI: 10.1074/jbc.M305685200  1
2003 Forman MS, Lee VM, Trojanowski JQ. 'Unfolding' pathways in neurodegenerative disease. Trends in Neurosciences. 26: 407-10. PMID 12900170 DOI: 10.1016/S0166-2236(03)00197-8  1
2003 Mishizen-Eberz AJ, Guttmann RP, Giasson BI, Day GA, Hodara R, Ischiropoulos H, Lee VM, Trojanowski JQ, Lynch DR. Distinct cleavage patterns of normal and pathologic forms of alpha-synuclein by calpain I in vitro. Journal of Neurochemistry. 86: 836-47. PMID 12887682 DOI: 10.1046/j.1471-4159.2003.01878.x  1
2003 Giasson BI, Lee VM. Are ubiquitination pathways central to Parkinson's disease? Cell. 114: 1-8. PMID 12859888 DOI: 10.1016/S0092-8674(03)00509-9  1
2003 Murray IV, Giasson BI, Quinn SM, Koppaka V, Axelsen PH, Ischiropoulos H, Trojanowski JQ, Lee VM. Role of alpha-synuclein carboxy-terminus on fibril formation in vitro. Biochemistry. 42: 8530-40. PMID 12859200 DOI: 10.1021/bi027363r  1
2003 Norris EH, Giasson BI, Ischiropoulos H, Lee VM. Effects of oxidative and nitrative challenges on alpha-synuclein fibrillogenesis involve distinct mechanisms of protein modifications. The Journal of Biological Chemistry. 278: 27230-40. PMID 12857790 DOI: 10.1074/jbc.M212436200  1
2003 Sampathu DM, Giasson BI, Pawlyk AC, Trojanowski JQ, Lee VM. Ubiquitination of alpha-synuclein is not required for formation of pathological inclusions in alpha-synucleinopathies. The American Journal of Pathology. 163: 91-100. PMID 12819014  1
2003 Giasson BI, Mabon ME, Duda JE, Montine TJ, Robertson D, Hurtig HI, Lee VM, Trojanowski JQ. Tau and 14-3-3 in glial cytoplasmic inclusions of multiple system atrophy. Acta Neuropathologica. 106: 243-50. PMID 12811584 DOI: 10.1007/s00401-003-0726-x  1
2003 Chalasani SH, Baribaud F, Coughlan CM, Sunshine MJ, Lee VM, Doms RW, Littman DR, Raper JA. The chemokine stromal cell-derived factor-1 promotes the survival of embryonic retinal ganglion cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 4601-12. PMID 12805300  1
2003 Phiel CJ, Wilson CA, Lee VM, Klein PS. GSK-3alpha regulates production of Alzheimer's disease amyloid-beta peptides. Nature. 423: 435-9. PMID 12761548 DOI: 10.1038/nature01640  0.88
2003 Watson DJ, Longhi L, Lee EB, Fulp CT, Fujimoto S, Royo NC, Passini MA, Trojanowski JQ, Lee VM, McIntosh TK, Wolfe JH. Genetically modified NT2N human neuronal cells mediate long-term gene expression as CNS grafts in vivo and improve functional cognitive outcome following experimental traumatic brain injury. Journal of Neuropathology and Experimental Neurology. 62: 368-80. PMID 12722829  1
2003 Giasson BI, Forman MS, Higuchi M, Golbe LI, Graves CL, Kotzbauer PT, Trojanowski JQ, Lee VM. Initiation and synergistic fibrillization of tau and alpha-synuclein. Science (New York, N.Y.). 300: 636-40. PMID 12714745 DOI: 10.1126/science.1082324  1
2003 Kung MP, Skovronsky DM, Hou C, Zhuang ZP, Gur TL, Zhang B, Trojanowski JQ, Lee VM, Kung HF. Detection of amyloid plaques by radioligands for Abeta40 and Abeta42: potential imaging agents in Alzheimer's patients. Journal of Molecular Neuroscience : Mn. 20: 15-24. PMID 12663930 DOI: 10.1385/JMN:20:1:15  1
2003 Crystal AS, Morais VA, Pierson TC, Pijak DS, Carlin D, Lee VM, Doms RW. Membrane topology of gamma-secretase component PEN-2. The Journal of Biological Chemistry. 278: 20117-23. PMID 12639958 DOI: 10.1074/jbc.M213107200  1
2003 Lee EB, Skovronsky DM, Abtahian F, Doms RW, Lee VM. Secretion and intracellular generation of truncated Abeta in beta-site amyloid-beta precursor protein-cleaving enzyme expressing human neurons. The Journal of Biological Chemistry. 278: 4458-66. PMID 12480937 DOI: 10.1074/jbc.M210105200  1
2002 Giasson BI, Sampathu DM, Wilson CA, Vogelsberg-Ragaglia V, Mushynski WE, Lee VM. The environmental toxin arsenite induces tau hyperphosphorylation. Biochemistry. 41: 15376-87. PMID 12484777 DOI: 10.1021/bi026813c  1
2002 Higuchi M, Lee VM, Trojanowski JQ. Tau and axonopathy in neurodegenerative disorders. Neuromolecular Medicine. 2: 131-50. PMID 12428808 DOI: 10.1385/NMM:2:2:131  1
2002 Trojanowski JQ, Lee VM. Parkinson's disease and related synucleinopathies are a new class of nervous system amyloidoses. Neurotoxicology. 23: 457-60. PMID 12428717  1
2002 Kung MP, Hou C, Zhuang ZP, Skovronsky DM, Zhang B, Gur TL, Trojanowski JQ, Lee VM, Kung HF. Radioiodinated styrylbenzene derivatives as potential SPECT imaging agents for amyloid plaque detection in Alzheimer's disease. Journal of Molecular Neuroscience : Mn. 19: 7-10. PMID 12212796 DOI: 10.1007/s12031-002-0003-9  1
2002 Duda JE, Giasson BI, Mabon ME, Lee VM, Trojanowski JQ. Novel antibodies to synuclein show abundant striatal pathology in Lewy body diseases. Annals of Neurology. 52: 205-10. PMID 12210791 DOI: 10.1002/ana.10279  1
2002 Trojanowski JQ, Lee VM. The role of tau in Alzheimer's disease. The Medical Clinics of North America. 86: 615-27. PMID 12168561  1
2002 Wilson CA, Doms RW, Zheng H, Lee VM. Presenilins are not required for A beta 42 production in the early secretory pathway. Nature Neuroscience. 5: 849-55. PMID 12145638 DOI: 10.1038/nn898  1
2002 Pan ZZ, Bruening W, Giasson BI, Lee VM, Godwin AK. Gamma-synuclein promotes cancer cell survival and inhibits stress- and chemotherapy drug-induced apoptosis by modulating MAPK pathways. The Journal of Biological Chemistry. 277: 35050-60. PMID 12121974 DOI: 10.1074/jbc.M201650200  1
2002 Trojanowski JQ, Ishihara T, Higuchi M, Yoshiyama Y, Hong M, Zhang B, Forman MS, Zhukareva V, Lee VM. Amyotrophic lateral sclerosis/parkinsonism dementia complex: transgenic mice provide insights into mechanisms underlying a common tauopathy in an ethnic minority on Guam. Experimental Neurology. 176: 1-11. PMID 12093078 DOI: 10.1006/exnr.2002.7940  1
2002 Duda JE, Giasson BI, Mabon ME, Miller DC, Golbe LI, Lee VM, Trojanowski JQ. Concurrence of alpha-synuclein and tau brain pathology in the Contursi kindred. Acta Neuropathologica. 104: 7-11. PMID 12070658 DOI: 10.1007/s00401-002-0563-3  1
2002 Giasson BI, Duda JE, Quinn SM, Zhang B, Trojanowski JQ, Lee VM. Neuronal alpha-synucleinopathy with severe movement disorder in mice expressing A53T human alpha-synuclein. Neuron. 34: 521-33. PMID 12062037 DOI: 10.1016/S0896-6273(02)00682-7  1
2002 Forman MS, Zhukareva V, Bergeron C, Chin SS, Grossman M, Clark C, Lee VM, Trojanowski JQ. Signature tau neuropathology in gray and white matter of corticobasal degeneration. The American Journal of Pathology. 160: 2045-53. PMID 12057909 DOI: 10.1016/S0002-9440(10)61154-6  1
2002 Giasson BI, Ischiropoulos H, Lee VM, Trojanowski JQ. The relationship between oxidative/nitrative stress and pathological inclusions in Alzheimer's and Parkinson's diseases. Free Radical Biology & Medicine. 32: 1264-75. PMID 12057764 DOI: 10.1016/S0891-5849(02)00804-3  1
2002 Forman MS, Schmidt ML, Kasturi S, Perl DP, Lee VM, Trojanowski JQ. Tau and alpha-synuclein pathology in amygdala of Parkinsonism-dementia complex patients of Guam. The American Journal of Pathology. 160: 1725-31. PMID 12000724  1
2002 Liu K, Doms RW, Lee VM. Glu11 site cleavage and N-terminally truncated A beta production upon BACE overexpression. Biochemistry. 41: 3128-36. PMID 11863452 DOI: 10.1021/bi015800g  1
2002 Huse JT, Liu K, Pijak DS, Carlin D, Lee VM, Doms RW. Beta-secretase processing in the trans-Golgi network preferentially generates truncated amyloid species that accumulate in Alzheimer's disease brain. The Journal of Biological Chemistry. 277: 16278-84. PMID 11847218 DOI: 10.1074/jbc.M111141200  1
2002 Mitchell TW, Mufson EJ, Schneider JA, Cochran EJ, Nissanov J, Han LY, Bienias JL, Lee VM, Trojanowski JQ, Bennett DA, Arnold SE. Parahippocampal tau pathology in healthy aging, mild cognitive impairment, and early Alzheimer's disease. Annals of Neurology. 51: 182-9. PMID 11835374 DOI: 10.1002/ana.10086  1
2002 Auluck PK, Chan HY, Trojanowski JQ, Lee VM, Bonini NM. Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease. Science (New York, N.Y.). 295: 865-8. PMID 11823645 DOI: 10.1126/science.1067389  1
2001 Trojanowski JQ, Lee VM. Brain degeneration linked to "fatal attractions" of proteins in Alzheimer's disease and related disorders. Journal of Alzheimer's Disease : Jad. 3: 117-119. PMID 12214080  1
2001 Giasson BI, Duda JE, Forman MS, Lee VM, Trojanowski JQ. Prominent perikaryal expression of alpha- and beta-synuclein in neurons of dorsal root ganglion and in medullary neurons. Experimental Neurology. 172: 354-62. PMID 11716559 DOI: 10.1006/exnr.2001.7805  1
2001 Paxinou E, Chen Q, Weisse M, Giasson BI, Norris EH, Rueter SM, Trojanowski JQ, Lee VM, Ischiropoulos H. Induction of alpha-synuclein aggregation by intracellular nitrative insult. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 8053-61. PMID 11588178  1
2001 Skovronsky DM, Fath S, Lee VM, Milla ME. Neuronal localization of the TNFalpha converting enzyme (TACE) in brain tissue and its correlation to amyloid plaques. Journal of Neurobiology. 49: 40-6. PMID 11536196 DOI: 10.1002/neu.1064  0.84
2001 Zhuang ZP, Kung MP, Hou C, Skovronsky DM, Gur TL, Plössl K, Trojanowski JQ, Lee VM, Kung HF. Radioiodinated styrylbenzenes and thioflavins as probes for amyloid aggregates. Journal of Medicinal Chemistry. 44: 1905-14. PMID 11384236 DOI: 10.1021/jm010045q  1
2001 Skovronsky DM, Lee VM, Praticò D. Amyloid precursor protein and amyloid beta peptide in human platelets. Role of cyclooxygenase and protein kinase C. The Journal of Biological Chemistry. 276: 17036-43. PMID 11278299 DOI: 10.1074/jbc.M006285200  1
2001 Giasson BI, Murray IV, Trojanowski JQ, Lee VM. A hydrophobic stretch of 12 amino acid residues in the middle of alpha-synuclein is essential for filament assembly. The Journal of Biological Chemistry. 276: 2380-6. PMID 11060312 DOI: 10.1074/jbc.M008919200  1
2000 Skovronsky DM, Wang J, Lee VM, Doms RW. Quantifying Aβ(1-40) and Aβ (1-42) Using Sandwich-ELISA. Methods in Molecular Medicine. 32: 79-89. PMID 21318512 DOI: 10.1385/1-59259-195-7:79  0.88
2000 Giasson BI, Duda JE, Murray IV, Chen Q, Souza JM, Hurtig HI, Ischiropoulos H, Trojanowski JQ, Lee VM. Oxidative damage linked to neurodegeneration by selective alpha-synuclein nitration in synucleinopathy lesions. Science (New York, N.Y.). 290: 985-9. PMID 11062131 DOI: 10.1126/science.290.5493.985  1
2000 Skovronsky DM, Zhang B, Kung MP, Kung HF, Trojanowski JQ, Lee VM. In vivo detection of amyloid plaques in a mouse model of Alzheimer's disease. Proceedings of the National Academy of Sciences of the United States of America. 97: 7609-14. PMID 10861023 DOI: 10.1073/pnas.97.13.7609  1
2000 Skovronsky DM, Lee VM. Beta-secretase revealed: starting gate for race to novel therapies for Alzheimer's disease. Trends in Pharmacological Sciences. 21: 161-3. PMID 10785643 DOI: 10.1016/S0165-6147(00)01467-X  1
2000 Skovronsky DM, Pijak DS, Doms RW, Lee VM. A distinct ER/IC gamma-secretase competes with the proteasome for cleavage of APP. Biochemistry. 39: 810-7. PMID 10651647 DOI: 10.1021/bi991728z  1
2000 Skovronsky DM, Moore DB, Milla ME, Doms RW, Lee VM. Protein kinase C-dependent alpha-secretase competes with beta-secretase for cleavage of amyloid-beta precursor protein in the trans-golgi network. The Journal of Biological Chemistry. 275: 2568-75. PMID 10644715 DOI: 10.1074/jbc.275.4.2568  1
1999 Wilson CA, Doms RW, Lee VM. Intracellular APP processing and A beta production in Alzheimer disease. Journal of Neuropathology and Experimental Neurology. 58: 787-94. PMID 10446803  1
1999 Muir JK, Raghupathi R, Saatman KE, Wilson CA, Lee VM, Trojanowski JQ, Philips MF, McIntosh TK. Terminally differentiated human neurons survive and integrate following transplantation into the traumatically injured rat brain. Journal of Neurotrauma. 16: 403-14. PMID 10369560  1
1998 Skovronsky DM, Doms RW, Lee VM. Detection of a novel intraneuronal pool of insoluble amyloid beta protein that accumulates with time in culture. The Journal of Cell Biology. 141: 1031-9. PMID 9585420 DOI: 10.1083/jcb.141.4.1031  1
1996 Cook DG, Turner RS, Kolson DL, Lee VM, Doms RW. Vaccinia virus serves as an efficient vector for expressing heterologous proteins in human NTera 2 neurons. The Journal of Comparative Neurology. 374: 481-92. PMID 8910730 DOI: 10.1002/(SICI)1096-9861(19961028)374:4<481::AID-CNE1>3.0.CO;2-Y  1
1996 Turner RS, Suzuki N, Chyung AS, Younkin SG, Lee VM. Amyloids beta40 and beta42 are generated intracellularly in cultured human neurons and their secretion increases with maturation. The Journal of Biological Chemistry. 271: 8966-70. PMID 8621541  1
1995 Merrick SE, Pleasure SJ, Lurie DI, Pijak DS, Selzer ME, Lee VM. Glial cells of the lamprey nervous system contain keratin-like proteins. The Journal of Comparative Neurology. 355: 199-210. PMID 7541809 DOI: 10.1002/cne.903550204  1
1993 Wertkin AM, Turner RS, Pleasure SJ, Golde TE, Younkin SG, Trojanowski JQ, Lee VM. Human neurons derived from a teratocarcinoma cell line express solely the 695-amino acid amyloid precursor protein and produce intracellular beta-amyloid or A4 peptides. Proceedings of the National Academy of Sciences of the United States of America. 90: 9513-7. PMID 8415732  1
1993 Pleasure SJ, Lee VM. NTera 2 cells: a human cell line which displays characteristics expected of a human committed neuronal progenitor cell. Journal of Neuroscience Research. 35: 585-602. PMID 8411264 DOI: 10.1002/jnr.490350603  1
1993 Younkin DP, Tang CM, Hardy M, Reddy UR, Shi QY, Pleasure SJ, Lee VM, Pleasure D. Inducible expression of neuronal glutamate receptor channels in the NT2 human cell line. Proceedings of the National Academy of Sciences of the United States of America. 90: 2174-8. PMID 7681588  1
1992 Pleasure SJ, Page C, Lee VM. Pure, postmitotic, polarized human neurons derived from NTera 2 cells provide a system for expressing exogenous proteins in terminally differentiated neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 1802-15. PMID 1578271  1
1991 Reddy UR, Pleasure S, Baker D, Lee VM, Ross AH, Pleasure D. Primitive neuroectodermal tumors (PNETs) of the CNS and PNS that express functional nerve growth factor receptors (NGFR) but fail to differentiate in response to NGF. Progress in Clinical and Biological Research. 366: 243-8. PMID 1648743  1
1990 Pleasure SJ, Reddy UR, Venkatakrishnan G, Roy AK, Chen J, Ross AH, Trojanowski JQ, Pleasure DE, Lee VM. Introduction of nerve growth factor (NGF) receptors into a medulloblastoma cell line results in expression of high- and low-affinity NGF receptors but not NGF-mediated differentiation. Proceedings of the National Academy of Sciences of the United States of America. 87: 8496-500. PMID 2172988  1
1990 Pleasure SJ, Lee VM, Nelson DL. Site-specific phosphorylation of the middle molecular weight human neurofilament protein in transfected non-neuronal cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 10: 2428-37. PMID 1695947  1
1989 Pleasure SJ, Selzer ME, Lee VM. Lamprey neurofilaments combine in one subunit the features of each mammalian NF triplet protein but are highly phosphorylated only in large axons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 9: 698-709. PMID 2493079  1
1984 Richter-Landsberg C, Lee VM, Salton SR, Shelanski ML, Greene LA. Release of the NILE and other glycoproteins from cultured PC12 rat pheochromocytoma cells and sympathetic neurons. Journal of Neurochemistry. 43: 841-8. PMID 6747638  0.72
1981 Lee VM, Greene L, Shelanski ML. Identification of neural and adrenal medullary surface membrane glycoproteins recognized by antisera to cultured rat sympathetic neurons and PC12 pheochromocytoma cells. Neuroscience. 6: 2773-86. PMID 7322360 DOI: 10.1016/0306-4522(81)90119-6  0.72
1980 Lee VM, Shelanski ML, Greene LA. Characterization of antisera raised against cultured rat sympathetic neurons. Neuroscience. 5: 2239-45. PMID 7007913 DOI: 10.1016/0306-4522(80)90140-2  0.72
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