| Year |
Citation |
Score |
| 2021 |
Rivas CM, Yee MC, Addison KJ, Lovett M, Pal K, Ledford JG, Dussor G, Price TJ, Vagner J, DeFea KA, Boitano S. Novel proteinase-activated receptor-2 (PAR2) antagonist C391 inhibits Alternaria-induced human airway epithelial signaling in vitro and asthma indicators in acute exposure murine models. British Journal of Pharmacology. PMID 34841515 DOI: 10.1111/bph.15745 |
0.703 |
|
| 2018 |
Yee MC, Nichols HL, Polley D, Saifeddine M, Pal K, Lee K, Wilson EH, Daines MO, Hollenberg MD, Boitano S, DeFea KA. Protease-activated Receptor-2 Signaling through β-Arrestin-2 Mediates Alternaria Alkaline Serine Protease-induced Airway Inflammation. American Journal of Physiology. Lung Cellular and Molecular Physiology. PMID 30335499 DOI: 10.1152/Ajplung.00196.2018 |
0.716 |
|
| 2016 |
Pal K, Hwang SH, Somatilaka B, Badgandi H, Jackson PK, DeFea K, Mukhopadhyay S. Smoothened determines β-arrestin-mediated removal of the G protein-coupled receptor Gpr161 from the primary cilium. The Journal of Cell Biology. PMID 27002170 DOI: 10.1083/Jcb.201506132 |
0.757 |
|
| 2015 |
Asaduzzaman M, Nadeem A, Arizmendi N, Davidson C, Nichols HL, Abel M, Ionescu LI, Puttagunta L, Thebaud B, Gordon J, DeFea K, Hollenberg MD, Vliagoftis H. Functional inhibition of PAR2 alleviates allergen-induced airway hyperresponsiveness and inflammation. Clinical and Experimental Allergy : Journal of the British Society For Allergy and Clinical Immunology. PMID 26312432 DOI: 10.1111/Cea.12628 |
0.355 |
|
| 2015 |
Boitano S, Hoffman J, Flynn AN, Asiedu MN, Tillu DV, Zhang Z, Sherwood CL, Rivas CM, DeFea K, Vagner J, Price TJ. The novel PAR2 ligand C391 blocks multiple PAR2 signaling pathways in vitro and in vivo. British Journal of Pharmacology. PMID 26140338 DOI: 10.1111/Bph.13238 |
0.457 |
|
| 2014 |
Walker JK, DeFea KA. Role for β-arrestin in mediating paradoxical β2AR and PAR2 signaling in asthma. Current Opinion in Pharmacology. 16: 142-7. PMID 24907413 DOI: 10.1016/j.coph.2014.03.007 |
0.465 |
|
| 2014 |
McGovern KW, DeFea KA. Molecular mechanisms underlying beta-arrestin-dependent chemotaxis and actin-cytoskeletal reorganization. Handbook of Experimental Pharmacology. 219: 341-59. PMID 24292838 DOI: 10.1007/978-3-642-41199-1_17 |
0.433 |
|
| 2013 |
Mittal N, Roberts K, Pal K, Bentolila LA, Fultz E, Minasyan A, Cahill C, Pradhan A, Conner D, DeFea K, Evans C, Walwyn W. Select G-protein-coupled receptors modulate agonist-induced signaling via a ROCK, LIMK, and β-arrestin 1 pathway. Cell Reports. 5: 1010-21. PMID 24239352 DOI: 10.1016/J.Celrep.2013.10.015 |
0.521 |
|
| 2013 |
DeFea KA. Arrestins in actin reorganization and cell migration. Progress in Molecular Biology and Translational Science. 118: 205-22. PMID 23764055 DOI: 10.1016/B978-0-12-394440-5.00008-5 |
0.471 |
|
| 2013 |
Lin A, DeFea KA. β-Arrestin-kinase scaffolds: turn them on or turn them off? Wiley Interdisciplinary Reviews. Systems Biology and Medicine. 5: 231-41. PMID 23319470 DOI: 10.1002/Wsbm.1203 |
0.455 |
|
| 2013 |
Pal K, Mathur M, Kumar P, DeFea K. Divergent β-arrestin-dependent signaling events are dependent upon sequences within G-protein-coupled receptor C termini. The Journal of Biological Chemistry. 288: 3265-74. PMID 23235155 DOI: 10.1074/Jbc.M112.400234 |
0.763 |
|
| 2013 |
Zahedi A, DeFea K, Ethell I. Optogenetics to target actin-mediated synaptic loss in Alzheimer's Proceedings of Spie. 8586. DOI: 10.1117/12.2000480 |
0.403 |
|
| 2012 |
Nichols HL, Saffeddine M, Theriot BS, Hegde A, Polley D, El-Mays T, Vliagoftis H, Hollenberg MD, Wilson EH, Walker JK, DeFea KA. β-Arrestin-2 mediates the proinflammatory effects of proteinase-activated receptor-2 in the airway. Proceedings of the National Academy of Sciences of the United States of America. 109: 16660-5. PMID 23012429 DOI: 10.1073/Pnas.1208881109 |
0.435 |
|
| 2012 |
Pontrello CG, Sun MY, Lin A, Fiacco TA, DeFea KA, Ethell IM. Cofilin under control of β-arrestin-2 in NMDA-dependent dendritic spine plasticity, long-term depression (LTD), and learning. Proceedings of the National Academy of Sciences of the United States of America. 109: E442-51. PMID 22308427 DOI: 10.1073/Pnas.1118803109 |
0.323 |
|
| 2012 |
Ramachandran R, Noorbakhsh F, Defea K, Hollenberg MD. Targeting proteinase-activated receptors: therapeutic potential and challenges. Nature Reviews. Drug Discovery. 11: 69-86. PMID 22212680 DOI: 10.1038/Nrd3615 |
0.492 |
|
| 2011 |
Min J, Defea K. β-arrestin-dependent actin reorganization: bringing the right players together at the leading edge. Molecular Pharmacology. 80: 760-8. PMID 21836019 DOI: 10.1124/Mol.111.072470 |
0.67 |
|
| 2011 |
Ramachandran R, Mihara K, Chung H, Renaux B, Lau CS, Muruve DA, DeFea KA, Bouvier M, Hollenberg MD. Neutrophil elastase acts as a biased agonist for proteinase-activated receptor-2 (PAR2). The Journal of Biological Chemistry. 286: 24638-48. PMID 21576245 DOI: 10.1074/Jbc.M110.201988 |
0.717 |
|
| 2011 |
Lau C, Lytle C, Straus DS, DeFea KA. Apical and basolateral pools of proteinase-activated receptor-2 direct distinct signaling events in the intestinal epithelium. American Journal of Physiology. Cell Physiology. 300: C113-23. PMID 21068362 DOI: 10.1152/Ajpcell.00162.2010 |
0.714 |
|
| 2011 |
DeFea KA. Beta-arrestins as regulators of signal termination and transduction: how do they determine what to scaffold? Cellular Signalling. 23: 621-9. PMID 20946952 DOI: 10.1016/J.Cellsig.2010.10.004 |
0.448 |
|
| 2010 |
Wang P, Jiang Y, Wang Y, Shyy JY, DeFea KA. Beta-arrestin inhibits CAMKKbeta-dependent AMPK activation downstream of protease-activated-receptor-2. Bmc Biochemistry. 11: 36. PMID 20858278 DOI: 10.1186/1471-2091-11-36 |
0.608 |
|
| 2010 |
Zoudilova M, Min J, Richards HL, Carter D, Huang T, DeFea KA. beta-Arrestins scaffold cofilin with chronophin to direct localized actin filament severing and membrane protrusions downstream of protease-activated receptor-2. The Journal of Biological Chemistry. 285: 14318-29. PMID 20207744 DOI: 10.1074/Jbc.M109.055806 |
0.757 |
|
| 2009 |
Ramachandran R, Mihara K, Mathur M, Rochdi MD, Bouvier M, Defea K, Hollenberg MD. Agonist-biased signaling via proteinase activated receptor-2: differential activation of calcium and mitogen-activated protein kinase pathways. Molecular Pharmacology. 76: 791-801. PMID 19605524 DOI: 10.1124/Mol.109.055509 |
0.8 |
|
| 2009 |
Shi Y, Pontrello CG, DeFea KA, Reichardt LF, Ethell IM. Focal adhesion kinase acts downstream of EphB receptors to maintain mature dendritic spines by regulating cofilin activity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 8129-42. PMID 19553453 DOI: 10.1523/Jneurosci.4681-08.2009 |
0.479 |
|
| 2009 |
Chen Z, Peng IC, Sun W, Su MI, Hsu PH, Fu Y, Zhu Y, DeFea K, Pan S, Tsai MD, Shyy JY. AMP-activated protein kinase functionally phosphorylates endothelial nitric oxide synthase Ser633. Circulation Research. 104: 496-505. PMID 19131647 DOI: 10.1161/Circresaha.108.187567 |
0.366 |
|
| 2008 |
DeFea KA. Beta-arrestin multimers: does a crowd help or hinder function? The Biochemical Journal. 413. PMID 18537791 DOI: 10.1042/Bj20081009 |
0.592 |
|
| 2007 |
Defea K. Beta-arrestins and heterotrimeric G-proteins: collaborators and competitors in signal transduction. British Journal of Pharmacology. S298-309. PMID 18037927 DOI: 10.1038/Sj.Bjp.0707508 |
0.561 |
|
| 2007 |
Petreaca ML, Yao M, Liu Y, Defea K, Martins-Green M. Transactivation of vascular endothelial growth factor receptor-2 by interleukin-8 (IL-8/CXCL8) is required for IL-8/CXCL8-induced endothelial permeability. Molecular Biology of the Cell. 18: 5014-23. PMID 17928406 DOI: 10.1091/Mbc.E07-01-0004 |
0.311 |
|
| 2007 |
Wang P, Kumar P, Wang C, Defea KA. Differential regulation of class IA phosphoinositide 3-kinase catalytic subunits p110 alpha and beta by protease-activated receptor 2 and beta-arrestins. The Biochemical Journal. 408: 221-30. PMID 17680774 DOI: 10.1042/Bj20070483 |
0.684 |
|
| 2007 |
Zoudilova M, Kumar P, Ge L, Wang P, Bokoch GM, DeFea KA. Beta-arrestin-dependent regulation of the cofilin pathway downstream of protease-activated receptor-2. The Journal of Biological Chemistry. 282: 20634-46. PMID 17500066 DOI: 10.1074/Jbc.M701391200 |
0.767 |
|
| 2007 |
Kumar P, Lau CS, Mathur M, Wang P, DeFea KA. Differential effects of beta-arrestins on the internalization, desensitization and ERK1/2 activation downstream of protease activated receptor-2. American Journal of Physiology. Cell Physiology. 293: C346-57. PMID 17442737 DOI: 10.1152/Ajpcell.00010.2007 |
0.769 |
|
| 2007 |
DeFea KA. Stop that cell! Beta-arrestin-dependent chemotaxis: a tale of localized actin assembly and receptor desensitization. Annual Review of Physiology. 69: 535-60. PMID 17002593 DOI: 10.1146/Annurev.Physiol.69.022405.154804 |
0.54 |
|
| 2007 |
Kumar P, Mathur M, Lau M, DeFea K. Multiple Independent Effects of Beta‐arrestins 1 & 2 in Protease Activated Receptor‐2 (PAR‐2) desensitization, internalization and signaling The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A246-A |
0.77 |
|
| 2006 |
Wang P, DeFea KA. Protease-activated receptor-2 simultaneously directs beta-arrestin-1-dependent inhibition and Galphaq-dependent activation of phosphatidylinositol 3-kinase. Biochemistry. 45: 9374-85. PMID 16878972 DOI: 10.1021/bi0602617 |
0.57 |
|
| 2004 |
Ge L, Shenoy SK, Lefkowitz RJ, DeFea K. Constitutive protease-activated receptor-2-mediated migration of MDA MB-231 breast cancer cells requires both beta-arrestin-1 and -2. The Journal of Biological Chemistry. 279: 55419-24. PMID 15489220 DOI: 10.1074/Jbc.M410312200 |
0.658 |
|
| 2003 |
Ge L, Ly Y, Hollenberg M, DeFea K. A beta-arrestin-dependent scaffold is associated with prolonged MAPK activation in pseudopodia during protease-activated receptor-2-induced chemotaxis. The Journal of Biological Chemistry. 278: 34418-26. PMID 12821670 DOI: 10.1074/Jbc.M300573200 |
0.749 |
|
| 2003 |
Lin T, Zeng L, Liu Y, DeFea K, Schwartz MA, Chien S, Shyy JY. Rho-ROCK-LIMK-cofilin pathway regulates shear stress activation of sterol regulatory element binding proteins. Circulation Research. 92: 1296-304. PMID 12775580 DOI: 10.1161/01.Res.0000078780.65824.8B |
0.419 |
|
| 2001 |
Déry O, Defea KA, Bunnett NW. Protein kinase C-mediated desensitization of the neurokinin 1 receptor American Journal of Physiology - Cell Physiology. 280. PMID 11287322 DOI: 10.1152/Ajpcell.2001.280.5.C1097 |
0.354 |
|
| 2000 |
DeFea KA, Vaughn ZD, O'Bryan EM, Nishijima D, Déry O, Bunnett NW. The proliferative and antiapoptotic effects of substance P are facilitated by formation of a β-arrestin-dependent scaffolding complex Proceedings of the National Academy of Sciences of the United States of America. 97: 11086-11091. PMID 10995467 DOI: 10.1073/Pnas.190276697 |
0.458 |
|
| 2000 |
DeFea KA, Zalevsky J, Thoma MS, Déry O, Mullins RD, Bunnett NW. beta-arrestin-dependent endocytosis of proteinase-activated receptor 2 is required for intracellular targeting of activated ERK1/2. The Journal of Cell Biology. 148: 1267-81. PMID 10725339 DOI: 10.1083/Jcb.148.6.1267 |
0.652 |
|
| 2000 |
DeFea K, Dery O, Schmidlin F, Bunnett NW. The Mechanism and Function of Agonist-Induced Trafficking of G-protein Coupled Receptors Biochemical Society Transactions. 28. DOI: 10.1042/Bst028A059B |
0.424 |
|
| 2000 |
DeFea K, Schmidlin F, Déry O, Grady EF, Bunnett NW. Mechanisms of initiation and termination of signalling by neuropeptide receptors: a comparison with the proteinase-activated receptors. Biochemical Society Transactions. 28: 419-426. DOI: 10.1042/Bst0280419 |
0.561 |
|
| 2000 |
Schmidlin F, Defea KA, Dery O, Lovett M, Vaughn ZD, Grady EF, Bunnett NW. Dynamin, B-arrestin and Rab5a mediated trafficking and signaling of the neurokinin 1 receptor (NK-1R) Regulatory Peptides. 94: 17. DOI: 10.1016/S0167-0115(00)80034-8 |
0.433 |
|
| 2000 |
Dery O, Lovett M, DeFea K, Bunnett NW. Protein kinase c (PKC)-induced desensitization of the neurokinin 1 receptor (NK1R): Diminished desensitization of a naturally occurring truncated receptor Gastroenterology. 118. DOI: 10.1016/S0016-5085(00)83306-5 |
0.453 |
|
| 2000 |
DeFea KA, Vaughn ZD, Dery O, Bunnett NW. B-Arrestin-dependent endocytosis of the neurokinin 1 receptor (NK1R) is required for activation of p42/44 map kinases Gastroenterology. 118. DOI: 10.1016/S0016-5085(00)82426-9 |
0.42 |
|
| 1999 |
Li J, DeFea K, Roth RA. Modulation of insulin receptor substrate-1 tyrosine phosphorylation by an Akt/phosphatidylinositol 3-kinase pathway Journal of Biological Chemistry. 274: 9351-9356. PMID 10092613 DOI: 10.1074/Jbc.274.14.9351 |
0.434 |
|
| Low-probability matches (unlikely to be authored by this person) |
| 2021 |
Rivas CM, Schiff HV, Moutal A, Khanna R, Kiela PR, Dussor G, Price TJ, Vagner J, DeFea KA, Boitano S. Alternaria alternata-induced airway epithelial signaling and inflammatory responses via protease-activated receptor-2 expression. Biochemical and Biophysical Research Communications. 591: 13-19. PMID 34990903 DOI: 10.1016/j.bbrc.2021.12.090 |
0.288 |
|
| 2008 |
Lee JW, Wang P, Kattah MG, Youssef S, Steinman L, DeFea K, Straus DS. Differential regulation of chemokines by IL-17 in colonic epithelial cells Journal of Immunology. 181: 6536-6545. PMID 18941244 DOI: 10.4049/Jimmunol.181.9.6536 |
0.288 |
|
| 2023 |
Mason BN, Hassler SN, DeFea K, Boitano S, Vagner J, Price TJ, Dussor G. PAR2 activation in the dura causes acute behavioral responses and priming to glyceryl trinitrate in a mouse migraine model. The Journal of Headache and Pain. 24: 42. PMID 37072694 DOI: 10.1186/s10194-023-01574-5 |
0.274 |
|
| 2022 |
Kume M, Ahmad A, Shiers S, Burton MD, DeFea KA, Vagner J, Dussor G, Boitano S, Price TJ. C781, a β-arrestin biased antagonist at protease-activated receptor-2 (PAR2), displays in vivo efficacy against protease-induced pain in mice. The Journal of Pain. PMID 36417966 DOI: 10.1016/j.jpain.2022.11.006 |
0.269 |
|
| 2008 |
Straus DS, Lee JW, DeFea K. T1228 Differential Regulation of Chemokines By Interleukin 17 in Colonic Epithelial Cells Gastroenterology. 134: A-511. DOI: 10.1016/S0016-5085(08)62385-9 |
0.264 |
|
| 1998 |
Hegde RS, Mastrianni JA, Scott MR, DeFea KA, Tremblay P, Torchia M, DeArmond SJ, Prusiner SB, Lingappa VR. A transmembrane form of the prion protein in neurodegenerative disease. Science (New York, N.Y.). 279: 827-34. PMID 9452375 DOI: 10.1126/Science.279.5352.827 |
0.251 |
|
| 2021 |
Lee AS, Tiwari S, Bishop I, Matossian V, Romaneschi N, Miyazaki T, VanderVeen L, Zalevsky J, DeFea K, Cahill CM, Walwyn WM. and Characterization of a Partial Mu Opioid Receptor Agonist, NKTR-181, Supports Future Therapeutic Development. Frontiers in Pain Research (Lausanne, Switzerland). 2: 695962. PMID 35295409 DOI: 10.3389/fpain.2021.695962 |
0.243 |
|
| 2022 |
Schiff HV, Rivas CM, Pederson WP, Sandoval E, Gillman S, Prisco J, Kume M, Dussor G, Vagner J, Ledford JG, Price TJ, DeFea KA, Boitano S. β-arrestin-biased proteinase-activated receptor-2 antagonist C781 limits allergen-induced airway hyperresponsiveness and inflammation. British Journal of Pharmacology. PMID 35735078 DOI: 10.1111/bph.15903 |
0.238 |
|
| 2019 |
DeFea K. Arresting CCR4: A New Look at an Old Approach to Combating Asthma. American Journal of Respiratory Cell and Molecular Biology. 58: 673-675. PMID 29856260 DOI: 10.1165/Rcmb.2017-0396Ed |
0.219 |
|
| 1988 |
Borejdo J, DeFea K. The orientation of DNA fragments in the agarose gels Analytical Biochemistry. 174: 393-398. PMID 3239744 DOI: 10.1016/0003-2697(88)90038-3 |
0.208 |
|
| 2023 |
Kume M, Ahmad A, DeFea KA, Vagner J, Dussor G, Boitano S, Price TJ. Protease-Activated Receptor 2 (PAR2) expressed in sensory neurons contributes to signs of pain and neuropathy in paclitaxel treated mice. The Journal of Pain. PMID 37315729 DOI: 10.1016/j.jpain.2023.06.006 |
0.117 |
|
| 2023 |
John S, Walwyn DR, DeFea K, Hales TG, Walwyn W. Editorial: Opioids in the time of the COVID-19 pandemic: from cellular mechanisms to public health policy. Frontiers in Pharmacology. 14: 1251958. PMID 37521481 DOI: 10.3389/fphar.2023.1251958 |
0.033 |
|
| Hide low-probability matches. |