Peter Århem - Publications

Affiliations: 
Karolinska Institute, Stockholm, Sweden 

70 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Ågren R, Zeberg H, Maciej Stępniewski T, Free RB, Reilly SW, Luedtke RR, Århem P, Ciruela F, Sibley DR, Mach RH, Selent J, Nilsson J, Sahlholm K. A ligand with two modes of interaction with the dopamine D2 receptor - An induced-fit mechanism of insurmountable antagonism. Acs Chemical Neuroscience. PMID 32865974 DOI: 10.1021/Acschemneuro.0C00477  0.784
2019 Ågren R, Nilsson J, Århem P. Closed and open state dependent block of potassium channels cause opposing effects on excitability - a computational approach. Scientific Reports. 9: 8175. PMID 31160624 DOI: 10.1038/S41598-019-44564-X  0.388
2018 Ågren R, Århem P, Nilsson J, Sahlholm K. The beta-arrestin-biased dopamine D2 receptor ligand, UNC9994, is a partial agonist at G-protein-mediated potassium channel activation. The International Journal of Neuropsychopharmacology. PMID 29986044 DOI: 10.1093/Ijnp/Pyy059  0.675
2018 Zeberg H, Nilsson J, Århem P. The Importance of the Dissociation Rate in Ion Channel Blocking. Frontiers in Cellular Neuroscience. 12: 33. PMID 29479308 DOI: 10.3389/Fncel.2018.00033  0.731
2018 Ågren R, Sahlholm K, Nilsson J, Århem P. Point mutation of a conserved aspartate, D69, in the muscarinic M2 receptor does not modify voltage-sensitive agonist potency. Biochemical and Biophysical Research Communications. PMID 29305262 DOI: 10.1016/J.Bbrc.2018.01.005  0.675
2016 Elinder F, Madeja M, Zeberg H, Århem P. Extracellular Linkers Completely Transplant the Voltage Dependence from Kv1.2 Ion Channels to Kv2.1. Biophysical Journal. 111: 1679-1691. PMID 27760355 DOI: 10.1016/J.Bpj.2016.08.043  0.765
2016 Sahlholm K, Zeberg H, Nilsson J, Ögren SO, Fuxe K, Århem P. The fast-off hypothesis revisited: A functional kinetic study of antipsychotic antagonism of the dopamine D2 receptor. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology. PMID 26811292 DOI: 10.1016/J.Euroneuro.2016.01.001  0.782
2015 Lyu C, Mulder J, Barde S, Sahlholm K, Zeberg H, Nilsson J, Århem P, Hökfelt T, Fried K, Shi TJ. G protein-gated inwardly rectifying potassium channel subunits 1 and 2 are down-regulated in rat dorsal root ganglion neurons and spinal cord after peripheral axotomy. Molecular Pain. 11: 44. PMID 26199148 DOI: 10.1186/S12990-015-0044-Z  0.77
2015 Zeberg H, Robinson HP, Århem P. Density of voltage-gated potassium channels is a bifurcation parameter in pyramidal neurons. Journal of Neurophysiology. 113: 537-49. PMID 25339708 DOI: 10.1152/Jn.00907.2013  0.752
2014 Sahlholm K, Marcellino D, Nilsson J, Ögren SO, Fuxe K, Ã…rhem P. Typical and atypical antipsychotics do not differ markedly in their reversibility of antagonism of the dopamine D2 receptor. The International Journal of Neuropsychopharmacology / Official Scientific Journal of the Collegium Internationale Neuropsychopharmacologicum (Cinp). 17: 149-55. PMID 24074141 DOI: 10.1017/S1461145713000801  0.717
2014 Sahlholm K, Zeberg H, Marcellino D, Nilsson J, Ogren S, Fuxe K, Arhem P. P.3.c.010 The fast-off hypothesis revisited: on-rates and reversibility of antipsychotic antagonism at the D2 receptor European Neuropsychopharmacology. 24: S520. DOI: 10.1016/S0924-977X(14)70833-8  0.772
2013 Shi TJ, Zhang MD, Zeberg H, Nilsson J, Grünler J, Liu SX, Xiang Q, Persson J, Fried KJ, Catrina SB, Watanabe M, Arhem P, Brismar K, Hökfelt TG. Coenzyme Q10 prevents peripheral neuropathy and attenuates neuron loss in the db-/db- mouse, a type 2 diabetes model. Proceedings of the National Academy of Sciences of the United States of America. 110: 690-5. PMID 23267110 DOI: 10.1073/Pnas.1220794110  0.689
2013 Sahlholm K, Ã…rhem P, Fuxe K, Marcellino D. The dopamine stabilizers ACR16 and (-)-OSU6162 display nanomolar affinities at the σ-1 receptor. Molecular Psychiatry. 18: 12-4. PMID 22349783 DOI: 10.1038/Mp.2012.3  0.654
2013 Nilsson J, Zeberg H, Madeja M, Arhem P. Local Anesthetics on Kv Channels - Closed State Binding of Bupivacaine? Biophysical Journal. 104: 126a. DOI: 10.1016/J.Bpj.2012.11.726  0.732
2013 Sahlholm K, Frisk S, Nilsson J, Marcellino D, Fuxe K, Ove Ögren S, Århem P. Novel Aspects of the Reversibility of the Antagonism at the Dopamine D2 Receptor by Antipsychotics Biophysical Journal. 104: 26a. DOI: 10.1016/J.Bpj.2012.11.183  0.719
2012 Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P. Voltage sensitivities and deactivation kinetics of histamine H₃ and Hâ‚„ receptors. Biochimica Et Biophysica Acta. 1818: 3081-9. PMID 22885137 DOI: 10.1016/J.Bbamem.2012.07.027  0.718
2012 Sahlholm K, Frisk S, Marcellino D, Nilsson J, Fuxe K, Århem P. P.1.030 Antagonist dissociation from dopamine D2 receptors: studies using a time-resolved ion channel activation assay European Neuropsychopharmacology. 22: S29. DOI: 10.1016/S0924-977X(12)70031-7  0.726
2012 Nilsson J, Kempka M, Arhem P. The Action of the Neuroprotective Compound Riluzole on Kv Channels Biophysical Journal. 102: 134a. DOI: 10.1016/J.Bpj.2011.11.742  0.388
2012 Zeberg H, Wolk A, Robinson H, Arhem P. Dynamic Clamp Conductance Injection Software Based on the QNX Real Time Operating System with Error Control and an Implicit Integration Method Biophysical Journal. 102: 595a. DOI: 10.1016/J.Bpj.2011.11.3243  0.728
2011 Sahlholm K, Barchad-Avitzur O, Marcellino D, Gómez-Soler M, Fuxe K, Ciruela F, Arhem P. Agonist-specific voltage sensitivity at the dopamine D2S receptor--molecular determinants and relevance to therapeutic ligands. Neuropharmacology. 61: 937-49. PMID 21752340 DOI: 10.1016/J.Neuropharm.2011.06.022  0.684
2011 Sahlholm K, Frisk S, Fuxe K, Århem P. P.3.d.010 Investigation of antagonist unbinding from dopamine D2 receptors using a real-time ion channel activation assay European Neuropsychopharmacology. 21: S511-S512. DOI: 10.1016/S0924-977X(11)70832-X  0.67
2010 Klement G, Druzin M, Haage D, Malinina E, Arhem P, Johansson S. Spontaneous ryanodine-receptor-dependent Ca2+-activated K+ currents and hyperpolarizations in rat medial preoptic neurons. Journal of Neurophysiology. 103: 2900-11. PMID 20457857 DOI: 10.1152/Jn.00566.2009  0.783
2010 Zeberg H, Blomberg C, Arhem P. Ion channel density regulates switches between regular and fast spiking in soma but not in axons. Plos Computational Biology. 6: e1000753. PMID 20421932 DOI: 10.1371/Journal.Pcbi.1000753  0.68
2010 Marcellino D, Navarro G, Sahlholm K, Nilsson J, Agnati LF, Canela EI, Lluís C, Ã…rhem P, Franco R, Fuxe K. Cocaine produces D2R-mediated conformational changes in the adenosine A(2A)R-dopamine D2R heteromer. Biochemical and Biophysical Research Communications. 394: 988-92. PMID 20307491 DOI: 10.1016/J.Bbrc.2010.03.104  0.685
2010 Zeberg H, Arhem P. Increasing the Potassium Channel Density in Regularly Spiking Pyramidal Cells can Turn them into Fast Spiking Biophysical Journal. 98: 140a. DOI: 10.1016/J.Bpj.2009.12.754  0.684
2010 Sahlholm K, Marcellino D, Nilsson J, Fuxe K, Århem P. Agonist-Specific Effects of TM V Serine Mutations on Dopamine D2S Receptor Voltage-Sensitivity Biophysical Journal. 98: 290a. DOI: 10.1016/J.Bpj.2009.12.1581  0.726
2010 Nilsson J, Madeja M, Sahlholm K, Arhem P. Kv Channel Modulation: Closed State Block of Benzocaine But Not of Bupivacaine Biophysical Journal. 98: 213a. DOI: 10.1016/J.Bpj.2009.12.1149  0.675
2009 Johanna N, Ullman H, Sahlholm K, Arhem P. Role of Aromatic Residues for Local Anaesthetic Binding to Ion Channels Biophysical Journal. 96: 561a-562a. DOI: 10.1016/J.Bpj.2008.12.3683  0.618
2009 Zeberg H, Blomberg C, Arhem P. Reptitive Firing In Neurons - Analysing The Interaction Between Channel Density And Kinetics In Membrane Models Biophysical Journal. 96: 480a. DOI: 10.1016/J.Bpj.2008.12.2474  0.685
2008 Sahlholm K, Marcellino D, Nilsson J, Fuxe K, Arhem P. Voltage-sensitivity at the human dopamine D2S receptor is agonist-specific. Biochemical and Biophysical Research Communications. 377: 1216-21. PMID 18983826 DOI: 10.1016/J.Bbrc.2008.10.117  0.728
2008 Nilsson J, Madeja M, Elinder F, Arhem P. Bupivacaine blocks N-type inactivating Kv channels in the open state: no allosteric effect on inactivation kinetics. Biophysical Journal. 95: 5138-52. PMID 18790854 DOI: 10.1529/Biophysj.108.130518  0.63
2008 Sahlholm K, Marcellino D, Nilsson J, Fuxe K, Arhem P. Differential voltage-sensitivity of D2-like dopamine receptors. Biochemical and Biophysical Research Communications. 374: 496-501. PMID 18652803 DOI: 10.1016/J.Bbrc.2008.07.052  0.721
2008 Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P. Electrophysiology-based analysis of human histamine H(4) receptor pharmacology using GIRK channel coupling in Xenopus oocytes. European Journal of Pharmacology. 591: 52-8. PMID 18582456 DOI: 10.1016/J.Ejphar.2008.06.029  0.714
2008 Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P. Voltage-dependence of the human dopamine D2 receptor. Synapse (New York, N.Y.). 62: 476-80. PMID 18361445 DOI: 10.1002/Syn.20509  0.729
2008 Klement G, Nilsson J, Arhem P, Elinder F. A tyrosine substitution in the cavity wall of a k channel induces an inverted inactivation. Biophysical Journal. 94: 3014-22. PMID 18192362 DOI: 10.1529/Biophysj.107.119842  0.738
2008 Århem P, Sahlholm K, Nilsson J. Mechanisms of Anaesthesia: A Role for Voltage-Gated K Channels? Anaesthesia Science. 117-127. DOI: 10.1002/9780470755297.ch9  0.675
2007 Elinder F, Nilsson J, Arhem P. On the opening of voltage-gated ion channels. Physiology & Behavior. 92: 1-7. PMID 17585963 DOI: 10.1016/J.Physbeh.2007.05.058  0.63
2007 Sahlholm K, Nilsson J, Marcellino D, Fuxe K, Arhem P. The human histamine H3 receptor couples to GIRK channels in Xenopus oocytes. European Journal of Pharmacology. 567: 206-10. PMID 17537431 DOI: 10.1016/J.Ejphar.2007.04.032  0.713
2007 Bränström R, Leibiger IB, Leibiger B, Klement G, Nilsson J, Arhem P, Aspinwall CA, Corkey BE, Larsson O, Berggren PO. Single residue (K332A) substitution in Kir6.2 abolishes the stimulatory effect of long-chain acyl-CoA esters: indications for a long-chain acyl-CoA ester binding motif. Diabetologia. 50: 1670-7. PMID 17522836 DOI: 10.1007/S00125-007-0697-X  0.674
2006 Arhem P, Klement G, Blomberg C. Channel density regulation of firing patterns in a cortical neuron model. Biophysical Journal. 90: 4392-404. PMID 16565052 DOI: 10.1529/biophysj.105.077032  0.583
2005 Persson AS, Klement G, Almgren M, Sahlholm K, Nilsson J, Petersson S, Arhem P, Schalling M, Lavebratt C. A truncated Kv1.1 protein in the brain of the megencephaly mouse: expression and interaction. Bmc Neuroscience. 6: 65. PMID 16305740 DOI: 10.1186/1471-2202-6-65  0.758
2003 Elinder F, Arhem P. Metal ion effects on ion channel gating. Quarterly Reviews of Biophysics. 36: 373-427. PMID 15267168 DOI: 10.1017/S0033583504003932  0.552
2003 Petersson S, Persson AS, Johansen JE, Ingvar M, Nilsson J, Klement G, Arhem P, Schalling M, Lavebratt C. Truncation of the Shaker-like voltage-gated potassium channel, Kv1.1, causes megencephaly. The European Journal of Neuroscience. 18: 3231-40. PMID 14686897 DOI: 10.1111/J.1460-9568.2003.03044.X  0.664
2003 Luzhkov VB, Nilsson J, Arhem P, Aqvist J. Computational modelling of the open-state Kv 1.5 ion channel block by bupivacaine. Biochimica Et Biophysica Acta. 1652: 35-51. PMID 14580995 DOI: 10.1016/J.Bbapap.2003.08.006  0.453
2003 Arhem P, Klement G, Nilsson J. Mechanisms of anesthesia: towards integrating network, cellular, and molecular level modeling. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 28: S40-7. PMID 12827143 DOI: 10.1038/Sj.Npp.1300142  0.651
2003 Nilsson J, Madeja M, Arhem P. Local anesthetic block of Kv channels: role of the S6 helix and the S5-S6 linker for bupivacaine action. Molecular Pharmacology. 63: 1417-29. PMID 12761353 DOI: 10.1124/Mol.63.6.1417  0.388
2001 Blomberg C, Elinder F, Arhem P. Na channel kinetics: developing models from non-stationary current fluctuations by analytic methods. Bio Systems. 62: 29-43. PMID 11595317 DOI: 10.1016/S0303-2647(01)00135-6  0.552
2001 Elinder F, Frankenhaeuser B, Arhem P. Non-stationary fluctuation analysis of the Na current in myelinated nerve fibers of Xenopus laevis: experiments and stochastic simulations. Bio Systems. 62: 13-28. PMID 11595316 DOI: 10.1016/S0303-2647(01)00134-4  0.757
2001 Elinder F, Arhem P, Larsson HP. Localization of the extracellular end of the voltage sensor S4 in a potassium channel. Biophysical Journal. 80: 1802-9. PMID 11259293 DOI: 10.1016/S0006-3495(01)76150-4  0.593
1999 Elinder F, Arhem P. Role of individual surface charges of voltage-gated K channels. Biophysical Journal. 77: 1358-62. PMID 10465747 DOI: 10.1016/S0006-3495(99)76984-5  0.552
1998 Nilsson J, Elinder F, Arhem P. Mechanisms of bupivacaine action on Na+ and K+ channels in myelinated axons of Xenopus laevis. European Journal of Pharmacology. 360: 21-9. PMID 9845268 DOI: 10.1016/S0014-2999(98)00631-1  0.63
1998 Elinder F, Liu Y, Arhem P. Divalent cation effects on the Shaker K channel suggest a pentapeptide sequence as determinant of functional surface charge density. The Journal of Membrane Biology. 165: 183-9. PMID 9745006 DOI: 10.1007/S002329900432  0.552
1998 Elinder F, Arhem P. The functional surface charge density of a fast K channel in the myelinated axon of Xenopus laevis. The Journal of Membrane Biology. 165: 175-81. PMID 9745005 DOI: 10.1007/S002329900431  0.552
1997 Elinder F, Arhem P. Tail currents in the myelinated axon of Xenopus laevis suggest a two-open-state Na channel. Biophysical Journal. 73: 179-85. PMID 9199782 DOI: 10.1016/S0006-3495(97)78058-5  0.552
1996 Elinder F, Madeja M, Arhem P. Surface Charges of K channels. Effects of strontium on five cloned channels expressed in Xenopus oocytes. The Journal of General Physiology. 108: 325-32. PMID 8894980 DOI: 10.1085/Jgp.108.4.325  0.552
1994 Elinder F, Arhem P. The modulatory site for the action of gadolinium on surface charges and channel gating. Biophysical Journal. 67: 84-90. PMID 7919028 DOI: 10.1016/S0006-3495(94)80457-6  0.552
1994 Elinder F, Arhem P. Effects of gadolinium on ion channels in the myelinated axon of Xenopus laevis: four sites of action. Biophysical Journal. 67: 71-83. PMID 7919027 DOI: 10.1016/S0006-3495(94)80456-4  0.552
1993 Elinder F, Arhem P. [Sodium channels and anti-arrhythmia agents. Time for a new classification?]. Lã¤Kartidningen. 90: 4545-9. PMID 8264290  0.552
1992 Veintemilla F, Elinder F, Arhem P. Mechanisms of propofol action on ion currents in the myelinated axon of Xenopus laevis. European Journal of Pharmacology. 218: 59-68. PMID 1383009 DOI: 10.1016/0014-2999(92)90147-V  0.552
1992 Westlind-Danielsson A, Ericsson G, Sandell L, Elinder F, Arhem P. High concentrations of the neuroleptic remoxipride block voltage-activated Na+ channels in central and peripheral nerve membranes. European Journal of Pharmacology. 224: 57-62. PMID 1333408 DOI: 10.1016/0014-2999(92)94818-G  0.552
1991 Elinder F, Arhem P. Mechanisms of the tetrahydroaminoacridine effect on action potential and ion currents in myelinated axons. European Journal of Pharmacology. 208: 1-8. PMID 1936128 DOI: 10.1016/0922-4106(91)90044-I  0.552
1991 Elinder F, Arhem P. Properties of the leakage current pathway: effects of the gadolinium ion on myelinated axons. Neuroreport. 2: 685-7. PMID 1725729 DOI: 10.1097/00001756-199111000-00013  0.552
1989 Elinder F, Mohammed AK, Winblad B, Arhem P. Effects of THA on ionic currents in myelinated axons of Xenopus laevis. European Journal of Pharmacology. 164: 599-602. PMID 2475350 DOI: 10.1016/0014-2999(89)90272-0  0.552
1982 Arhem P, Frankenhaeuser B, Kristbjarnarson H. Inactivation of the potassium transport system of myelinated nerve in the presence of a cyclic ionophore. Acta Physiologica Scandinavica. 114: 593-600. PMID 7136788 DOI: 10.1111/J.1748-1716.1982.Tb07029.X  0.75
1976 Frankenhaeuser B, Ryan KJ, Arhem P. The effects of neuraminidase and protamine chloride on potential clamp parameters of the node of Ranvier (Xenopus laevis). Acta Physiologica Scandinavica. 96: 548-57. PMID 1274627 DOI: 10.1111/j.1748-1716.1976.tb10225.x  0.75
1975 Frankenhaeuser B, Arhem P. Steady state current rectification in potential clamped nodes of Ranvier (Xenopus laevis). Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 270: 515-25. PMID 238247  0.75
1974 Arhem P, Frankenhaeuser B. Local anesthetics: effects on permeability properties of nodal membrane in myelinated nerve fibres from xenopus. Potential clamp experiments. Acta Physiologica Scandinavica. 91: 11-21. PMID 4835707 DOI: 10.1111/J.1748-1716.1974.Tb05652.X  0.75
1974 Arhem P, Frankenhaeuser B, Göthe R, O'Bryan P. DDT and related substances on myelinated nerve: effects on permeability properties. Acta Physiologica Scandinavica. 91: 130-2. PMID 4545715 DOI: 10.1111/j.1748-1716.1974.tb05665.x  0.75
1974 Arhem P, Frankenhaeuser B. DDT and related substances: effects on permeability properties of myelinated xenopus nerve fibre. Potential clamp analysis. Acta Physiologica Scandinavica. 91: 502-11. PMID 4215287 DOI: 10.1111/j.1748-1716.1974.tb05706.x  0.75
1973 Arhem P, Frankenhaeuser B, Moore LE. Ionic currents at resting potential in nerve fibres from Xenopus laevis. Potential clamp experiments. Acta Physiologica Scandinavica. 88: 446-54. PMID 4765596 DOI: 10.1111/J.1748-1716.1973.Tb05474.X  0.757
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