Charleen T. Chu, MD, Duke University, PhD, Duke University - Publications

Affiliations: 
Pathology University of Pittsburgh, Pittsburgh, PA, United States 
Area:
Neuropathology, Parkinson's disease, mitochondria, autophagy
Website:
http://path.upmc.edu/personnel/Faculty/Chu.htm

113 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Yang M, Wang Y, Liang G, Xu Z, Chu CT, Wei H. Alzheimer's Disease Presenilin-1 Mutation Sensitizes Neurons to Impaired Autophagy Flux and Propofol Neurotoxicity: Role of Calcium Dysregulation. Journal of Alzheimer's Disease : Jad. 67: 137-147. PMID 30636740 DOI: 10.3233/JAD-180858  1
2018 Wang KZQ, Steer E, Otero PA, Bateman NW, Cheng MH, Scott AL, Wu C, Bahar I, Shih YT, Hsueh YP, Chu CT. PINK1 Interacts with VCP/p97 and Activates PKA to Promote NSFL1C/p47 Phosphorylation and Dendritic Arborization in Neurons. Eneuro. 5. PMID 30783609 DOI: 10.1523/ENEURO.0466-18.2018  1
2018 Verma M, Wills Z, Chu CT. Excitatory Dendritic Mitochondrial Calcium Toxicity: Implications for Parkinson's and Other Neurodegenerative Diseases. Frontiers in Neuroscience. 12: 523. PMID 30116173 DOI: 10.3389/fnins.2018.00523  1
2017 Verma M, Callio J, Otero PA, Sekler I, Wills ZP, Chu C. Mitochondrial calcium dysregulation contributes to dendrite degeneration mediated by PD/LBD-associated LRRK2 mutants. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29038245 DOI: 10.1523/JNEUROSCI.3791-16.2017  1
2017 Galluzzi L, Baehrecke EH, Ballabio A, Boya P, Bravo-San Pedro JM, Cecconi F, Choi AM, Chu CT, Codogno P, Colombo MI, Cuervo AM, Debnath J, Deretic V, Dikic I, Eskelinen EL, et al. Molecular definitions of autophagy and related processes. The Embo Journal. PMID 28596378 DOI: 10.15252/embj.201796697  1
2017 DasBanerjee T, Dagda RY, Dagda M, Chu CT, Rice M, Vazquez-Mayorga E, Dagda RK. PINK1 Regulates Mitochondrial Trafficking in Dendrites of Cortical Neurons through Mitochondrial PKA. Journal of Neurochemistry. PMID 28556983 DOI: 10.1111/jnc.14083  1
2017 Gusdon AM, Callio J, DiStefano G, O'Doherty RM, Goodpaster BH, Coen PM, Chu CT. Exercise increases mitochondrial complex I activity and DRP1 expression in the brains of aged mice. Experimental Gerontology. PMID 28108329 DOI: 10.1016/j.exger.2017.01.013  1
2016 Ravi S, Peña KA, Chu CT, Kiselyov K. Biphasic regulation of lysosomal exocytosis by oxidative stress. Cell Calcium. PMID 27593159 DOI: 10.1016/j.ceca.2016.08.002  1
2016 Di Maio R, Barrett PJ, Hoffman EK, Barrett CW, Zharikov A, Borah A, Hu X, McCoy J, Chu CT, Burton EA, Hastings TG, Greenamyre JT. α-Synuclein binds to TOM20 and inhibits mitochondrial protein import in Parkinson's disease. Science Translational Medicine. 8: 342ra78. PMID 27280685 DOI: 10.1126/scitranslmed.aaf3634  1
2016 Banerjee K, Munshi S, Xu H, Frank DE, Chen HL, Chu CT, Yang J, Cho S, Kagan VE, Denton TT, Tyurina YY, Jiang JF, Gibson GE. Mild mitochondrial metabolic deficits by α-ketoglutarate dehydrogenase inhibition cause prominent changes in intracellular autophagic signaling: Potential role in the pathobiology of Alzheimer's disease. Neurochemistry International. PMID 26923918 DOI: 10.1016/j.neuint.2016.02.011  1
2016 Klionsky DJ, Abdelmohsen K, Abe A, Abedin MJ, Abeliovich H, Acevedo Arozena A, Adachi H, Adams CM, Adams PD, Adeli K, Adhihetty PJ, Adler SG, Agam G, Agarwal R, Aghi MK, ... ... Chu CT, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 12: 1-222. PMID 26799652 DOI: 10.1080/15548627.2015.1100356  0.48
2015 Kostic M, Ludtmann MH, Bading H, Hershfinkel M, Steer E, Chu CT, Abramov AY, Sekler I. PKA Phosphorylation of NCLX Reverses Mitochondrial Calcium Overload and Depolarization, Promoting Survival of PINK1-Deficient Dopaminergic Neurons. Cell Reports. 13: 376-86. PMID 26440884 DOI: 10.1016/j.celrep.2015.08.079  1
2015 Chiang CH, Chu CT, Wiley CA. A 67 Year-Old Man with Multiple Sclerosis and New Cerebellar Lesions. Brain Pathology (Zurich, Switzerland). 25: 507-8. PMID 26095593 DOI: 10.1111/bpa.12269  1
2015 Au AK, Chen Y, Lina D, Smith CM, Manole MD, Baltagi SA, Chu CT, Aneja RK, Bay?r H, Kochanek PM, Clark RS. Ischemia-induced autophagy contributes to neurodegeneration in cerebellar Purkinje cells in the developing rat brain and in primary cortical neurons in vitro. Biochimica Et Biophysica Acta. PMID 26071643 DOI: 10.1016/j.bbadis.2015.06.007  1
2015 Chen BB, Coon TA, Glasser JR, Zou C, Ellis B, Das T, McKelvey AC, Rajbhandari S, Lear T, Kamga C, Shiva S, Li C, Pilewski JM, Callio J, Chu CT, et al. E3 Ligase Subunit Fbxo15 and PINK1 Kinase Impair Cardiolipin Synthase 1 Stability and Mitochondrial Function in Experimental Lung Injury. Annals of the American Thoracic Society. 12: S76. PMID 25830852 DOI: 10.1513/AnnalsATS.201407-319MG  1
2015 Bueno M, Lai YC, Romero Y, Brands J, St Croix CM, Kamga C, Corey C, Herazo-Maya JD, Sembrat J, Lee JS, Duncan SR, Rojas M, Shiva S, Chu CT, Mora AL. PINK1 deficiency impairs mitochondrial homeostasis and promotes lung fibrosis. The Journal of Clinical Investigation. 125: 521-38. PMID 25562319 DOI: 10.1172/JCI74942  1
2015 Steer EK, Dail MK, Chu CT. Beyond mitophagy: cytosolic PINK1 as a messenger of mitochondrial health. Antioxidants & Redox Signaling. 22: 1047-59. PMID 25557302 DOI: 10.1089/ars.2014.6206  1
2015 Gusdon AM, Fang F, Chen J, Mathews CE, Li W, Chu CT, Ding JQ, Chen SD. Association of the mt-ND2 5178A/C polymorphism with Parkinson's disease. Neuroscience Letters. 587: 98-101. PMID 25511548 DOI: 10.1016/j.neulet.2014.12.005  1
2014 Sanders LH, McCoy J, Hu X, Mastroberardino PG, Dickinson BC, Chang CJ, Chu CT, Van Houten B, Greenamyre JT. Mitochondrial DNA damage: molecular marker of vulnerable nigral neurons in Parkinson's disease. Neurobiology of Disease. 70: 214-23. PMID 24981012 DOI: 10.1016/j.nbd.2014.06.014  1
2014 Plowey ED, Johnson JW, Steer E, Zhu W, Eisenberg DA, Valentino NM, Liu YJ, Chu CT. Mutant LRRK2 enhances glutamatergic synapse activity and evokes excitotoxic dendrite degeneration. Biochimica Et Biophysica Acta. 1842: 1596-603. PMID 24874075 DOI: 10.1016/j.bbadis.2014.05.016  1
2014 Patel VP, Chu CT. Decreased SIRT2 activity leads to altered microtubule dynamics in oxidatively-stressed neuronal cells: implications for Parkinson's disease. Experimental Neurology. 257: 170-81. PMID 24792244 DOI: 10.1016/j.expneurol.2014.04.024  1
2014 Wang KZ, Zhu J, Dagda RK, Uechi G, Cherra SJ, Gusdon AM, Balasubramani M, Chu CT. ERK-mediated phosphorylation of TFAM downregulates mitochondrial transcription: implications for Parkinson's disease. Mitochondrion. 17: 132-40. PMID 24768991 DOI: 10.1016/j.mito.2014.04.008  1
2014 Chen BB, Coon TA, Glasser JR, Zou C, Ellis B, Das T, McKelvey AC, Rajbhandari S, Lear T, Kamga C, Shiva S, Li C, Pilewski JM, Callio J, Chu CT, et al. E3 ligase subunit Fbxo15 and PINK1 kinase regulate cardiolipin synthase 1 stability and mitochondrial function in pneumonia. Cell Reports. 7: 476-87. PMID 24703837 DOI: 10.1016/j.celrep.2014.02.048  1
2014 Chu CT, Bayır H, Kagan VE. LC3 binds externalized cardiolipin on injured mitochondria to signal mitophagy in neurons: implications for Parkinson disease. Autophagy. 10: 376-8. PMID 24351649 DOI: 10.4161/auto.27191  1
2014 Kagan VE, Chu CT, Tyurina YY, Cheikhi A, Bayir H. Cardiolipin asymmetry, oxidation and signaling. Chemistry and Physics of Lipids. 179: 64-9. PMID 24300280 DOI: 10.1016/j.chemphyslip.2013.11.010  1
2014 Verma M, Steer EK, Chu CT. ERKed by LRRK2: a cell biological perspective on hereditary and sporadic Parkinson's disease. Biochimica Et Biophysica Acta. 1842: 1273-81. PMID 24225420 DOI: 10.1016/j.bbadis.2013.11.005  1
2014 Dagda RK, Pien I, Wang R, Zhu J, Wang KZ, Callio J, Banerjee TD, Dagda RY, Chu CT. Beyond the mitochondrion: cytosolic PINK1 remodels dendrites through protein kinase A. Journal of Neurochemistry. 128: 864-77. PMID 24151868 DOI: 10.1111/jnc.12494  1
2014 Kamga Pride C, Mo L, Quesnelle K, Dagda RK, Murillo D, Geary L, Corey C, Portella R, Zharikov S, St Croix C, Maniar S, Chu CT, Khoo NK, Shiva S. Nitrite activates protein kinase A in normoxia to mediate mitochondrial fusion and tolerance to ischaemia/reperfusion. Cardiovascular Research. 101: 57-68. PMID 24081164 DOI: 10.1093/cvr/cvt224  1
2013 Chu CT, Ji J, Dagda RK, Jiang JF, Tyurina YY, Kapralov AA, Tyurin VA, Yanamala N, Shrivastava IH, Mohammadyani D, Qiang Wang KZ, Zhu J, Klein-Seetharaman J, Balasubramanian K, Amoscato AA, et al. Cardiolipin externalization to the outer mitochondrial membrane acts as an elimination signal for mitophagy in neuronal cells. Nature Cell Biology. 15: 1197-205. PMID 24036476 DOI: 10.1038/ncb2837  1
2013 Zhu J, Wang KZ, Chu CT. After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy. 9: 1663-76. PMID 23787782 DOI: 10.4161/auto.24135  1
2013 Oczypok EA, Oury TD, Chu CT. It's a cell-eat-cell world: autophagy and phagocytosis. The American Journal of Pathology. 182: 612-22. PMID 23369575 DOI: 10.1016/j.ajpath.2012.12.017  1
2013 Knickelbein JE, Kovarik J, Dhaliwal DK, Chu CT. Acanthamoeba keratitis: a clinicopathologic case report and review of the literature. Human Pathology. 44: 918-22. PMID 23332929 DOI: 10.1016/j.humpath.2012.10.007  1
2013 Cherra SJ, Steer E, Gusdon AM, Kiselyov K, Chu CT. Mutant LRRK2 elicits calcium imbalance and depletion of dendritic mitochondria in neurons. The American Journal of Pathology. 182: 474-84. PMID 23231918 DOI: 10.1016/j.ajpath.2012.10.027  1
2012 Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K, Agholme L, Agnello M, Agostinis P, Aguirre-Ghiso JA, Ahn HJ, Ait-Mohamed O, Ait-Si-Ali S, Akematsu T, Akira S, ... ... Chu CT, et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy. 8: 445-544. PMID 22966490  1
2012 Patel VP, Defranco DB, Chu CT. Altered transcription factor trafficking in oxidatively-stressed neuronal cells. Biochimica Et Biophysica Acta. 1822: 1773-82. PMID 22902725 DOI: 10.1016/j.bbadis.2012.08.002  1
2012 Zhu JH, Gusdon AM, Cimen H, Van Houten B, Koc E, Chu CT. Impaired mitochondrial biogenesis contributes to depletion of functional mitochondria in chronic MPP+ toxicity: dual roles for ERK1/2. Cell Death & Disease. 3: e312. PMID 22622131 DOI: 10.1038/cddis.2012.46  1
2012 Gusdon AM, Zhu J, Van Houten B, Chu CT. ATP13A2 regulates mitochondrial bioenergetics through macroautophagy. Neurobiology of Disease. 45: 962-72. PMID 22198378 DOI: 10.1016/j.nbd.2011.12.015  1
2012 Chu CT. Introduction. Autophagy dysregulation in neuropathology. Brain Pathology (Zurich, Switzerland). 22: 80-1. PMID 22150922 DOI: 10.1111/j.1750-3639.2011.00547.x  1
2011 Simon DK, Chu CT, Swerdlow RH. Mitochondria and Parkinson's disease. Parkinson's Disease. 2011: 261791. PMID 22973533 DOI: 10.4061/2011/261791  1
2011 Klionsky DJ, Baehrecke EH, Brumell JH, Chu CT, Codogno P, Cuervo AM, Debnath J, Deretic V, Elazar Z, Eskelinen EL, Finkbeiner S, Fueyo-Margareto J, Gewirtz D, Jäättelä M, Kroemer G, et al. A comprehensive glossary of autophagy-related molecules and processes (2nd edition). Autophagy. 7: 1273-94. PMID 21997368 DOI: 10.4161/auto.7.11.17661  1
2011 Zhu J, Dagda RK, Chu CT. Monitoring mitophagy in neuronal cell cultures. Methods in Molecular Biology (Clifton, N.J.). 793: 325-39. PMID 21913110 DOI: 10.1007/978-1-61779-328-8_21  1
2011 Dagda RK, Gusdon AM, Pien I, Strack S, Green S, Li C, Van Houten B, Cherra SJ, Chu CT. Mitochondrially localized PKA reverses mitochondrial pathology and dysfunction in a cellular model of Parkinson's disease. Cell Death and Differentiation. 18: 1914-23. PMID 21637291 DOI: 10.1038/cdd.2011.74  1
2011 Patel VP, Chu CT. Nuclear transport, oxidative stress, and neurodegeneration. International Journal of Clinical and Experimental Pathology. 4: 215-29. PMID 21487518  1
2011 Hu X, Weng Z, Chu CT, Zhang L, Cao G, Gao Y, Signore A, Zhu J, Hastings T, Greenamyre JT, Chen J. Peroxiredoxin-2 protects against 6-hydroxydopamine-induced dopaminergic neurodegeneration via attenuation of the apoptosis signal-regulating kinase (ASK1) signaling cascade. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 247-61. PMID 21209210 DOI: 10.1523/JNEUROSCI.4589-10.2011  1
2011 Van Laar VS, Arnold B, Cassady SJ, Chu CT, Burton EA, Berman SB. Bioenergetics of neurons inhibit the translocation response of Parkin following rapid mitochondrial depolarization. Human Molecular Genetics. 20: 927-40. PMID 21147754 DOI: 10.1093/hmg/ddq531  1
2011 Gusdon AM, Chu CT. To eat or not to eat: neuronal metabolism, mitophagy, and Parkinson's disease. Antioxidants & Redox Signaling. 14: 1979-87. PMID 21126205 DOI: 10.1089/ars.2010.3763  1
2011 Plowey ED, Chu CT. Synaptic dysfunction in genetic models of Parkinson's disease: a role for autophagy? Neurobiology of Disease. 43: 60-7. PMID 20969957 DOI: 10.1016/j.nbd.2010.10.011  1
2010 Cherra SJ, Kulich SM, Uechi G, Balasubramani M, Mountzouris J, Day BW, Chu CT. Regulation of the autophagy protein LC3 by phosphorylation. The Journal of Cell Biology. 190: 533-9. PMID 20713600 DOI: 10.1083/jcb.201002108  1
2010 Zhu J, Chu CT. Mitochondrial dysfunction in Parkinson's disease. Journal of Alzheimer's Disease : Jad. 20: S325-34. PMID 20442495 DOI: 10.3233/JAD-2010-100363  1
2010 Cherra SJ, Dagda RK, Chu CT. Review: autophagy and neurodegeneration: survival at a cost? Neuropathology and Applied Neurobiology. 36: 125-32. PMID 20202120 DOI: 10.1111/j.1365-2990.2010.01062.x  1
2010 Chu CR, Coyle CH, Chu CT, Szczodry M, Seshadri V, Karpie JC, Cieslak KM, Pringle EK. In vivo effects of single intra-articular injection of 0.5% bupivacaine on articular cartilage. The Journal of Bone and Joint Surgery. American Volume. 92: 599-608. PMID 20194318 DOI: 10.2106/JBJS.I.00425  1
2010 Bear DM, Williams A, Chu CT, Coyle CH, Chu CR. Optical coherence tomography grading correlates with MRI T2 mapping and extracellular matrix content. Journal of Orthopaedic Research : Official Publication of the Orthopaedic Research Society. 28: 546-52. PMID 19834953 DOI: 10.1002/jor.20998  1
2009 Dagda RK, Chu CT. Mitochondrial quality control: insights on how Parkinson's disease related genes PINK1, parkin, and Omi/HtrA2 interact to maintain mitochondrial homeostasis. Journal of Bioenergetics and Biomembranes. 41: 473-9. PMID 20012177 DOI: 10.1007/s10863-009-9255-1  1
2009 Cherra SJ, Dagda RK, Tandon A, Chu CT. Mitochondrial autophagy as a compensatory response to PINK1 deficiency. Autophagy. 5: 1213-4. PMID 19786829 DOI: 10.4161/auto.5.8.10050  1
2009 Voeghtly LM, Thøgersen IB, Valnickova Z, Sanggaard KW, Chu CT, Oury TD, Enghild JJ. Potential clinical importance of the activation peptide of prostate-specific antigen. International Journal of Clinical and Experimental Pathology. 2: 588-98. PMID 19636406  1
2009 Dagda RK, Zhu J, Chu CT. Mitochondrial kinases in Parkinson's disease: converging insights from neurotoxin and genetic models. Mitochondrion. 9: 289-98. PMID 19563915 DOI: 10.1016/j.mito.2009.06.001  1
2009 Bayir H, Kapralov AA, Jiang J, Huang Z, Tyurina YY, Tyurin VA, Zhao Q, Belikova NA, Vlasova II, Maeda A, Zhu J, Na HM, Mastroberardino PG, Sparvero LJ, Amoscato AA, ... Chu CT, et al. Peroxidase mechanism of lipid-dependent cross-linking of synuclein with cytochrome C: protection against apoptosis versus delayed oxidative stress in Parkinson disease. The Journal of Biological Chemistry. 284: 15951-69. PMID 19351880 DOI: 10.1074/jbc.M900418200  1
2009 Dagda RK, Cherra SJ, Kulich SM, Tandon A, Park D, Chu CT. Loss of PINK1 function promotes mitophagy through effects on oxidative stress and mitochondrial fission. The Journal of Biological Chemistry. 284: 13843-55. PMID 19279012 DOI: 10.1074/jbc.M808515200  1
2009 Mastroberardino PG, Hoffman EK, Horowitz MP, Betarbet R, Taylor G, Cheng D, Na HM, Gutekunst CA, Gearing M, Trojanowski JQ, Anderson M, Chu CT, Peng J, Greenamyre JT. A novel transferrin/TfR2-mediated mitochondrial iron transport system is disrupted in Parkinson's disease. Neurobiology of Disease. 34: 417-31. PMID 19250966 DOI: 10.1016/j.nbd.2009.02.009  1
2009 Chu CT, Plowey ED, Dagda RK, Hickey RW, Cherra SJ, Clark RS. Autophagy in neurite injury and neurodegeneration: in vitro and in vivo models. Methods in Enzymology. 453: 217-49. PMID 19216909 DOI: 10.1016/S0076-6879(08)04011-1  1
2009 Du L, Hickey RW, Bayir H, Watkins SC, Tyurin VA, Guo F, Kochanek PM, Jenkins LW, Ren J, Gibson G, Chu CT, Kagan VE, Clark RS. Starving neurons show sex difference in autophagy. The Journal of Biological Chemistry. 284: 2383-96. PMID 19036730 DOI: 10.1074/jbc.M804396200  1
2009 Horbinski C, Dacic S, McLendon RE, Cieply K, Datto M, Brat DJ, Chu CT. Chordoid glioma: a case report and molecular characterization of five cases. Brain Pathology (Zurich, Switzerland). 19: 439-48. PMID 18652591 DOI: 10.1111/j.1750-3639.2008.00196.x  1
2008 Cherra SJ, Chu CT. Autophagy in neuroprotection and neurodegeneration: A question of balance. Future Neurology. 3: 309-323. PMID 18806889 DOI: 10.2217/14796708.3.3.309  1
2008 Dagda RK, Zhu J, Kulich SM, Chu CT. Mitochondrially localized ERK2 regulates mitophagy and autophagic cell stress: implications for Parkinson's disease. Autophagy. 4: 770-82. PMID 18594198  1
2008 Klionsky DJ, Abeliovich H, Agostinis P, Agrawal DK, Aliev G, Askew DS, Baba M, Baehrecke EH, Bahr BA, Ballabio A, Bamber BA, Bassham DC, Bergamini E, Bi X, Biard-Piechaczyk M, ... ... Chu CT, et al. Guidelines for the use and interpretation of assays for monitoring autophagy in higher eukaryotes. Autophagy. 4: 151-75. PMID 18188003  1
2008 Plowey ED, Cherra SJ, Liu YJ, Chu CT. Role of autophagy in G2019S-LRRK2-associated neurite shortening in differentiated SH-SY5Y cells. Journal of Neurochemistry. 105: 1048-56. PMID 18182054 DOI: 10.1111/j.1471-4159.2008.05217.x  1
2008 Clark RS, Bayir H, Chu CT, Alber SM, Kochanek PM, Watkins SC. Autophagy is increased in mice after traumatic brain injury and is detectable in human brain after trauma and critical illness. Autophagy. 4: 88-90. PMID 17957135  1
2008 Lai Y, Hickey RW, Chen Y, Bayir H, Sullivan ML, Chu CT, Kochanek PM, Dixon CE, Jenkins LW, Graham SH, Watkins SC, Clark RS. Autophagy is increased after traumatic brain injury in mice and is partially inhibited by the antioxidant gamma-glutamylcysteinyl ethyl ester. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 28: 540-50. PMID 17786151 DOI: 10.1038/sj.jcbfm.9600551  1
2007 Chu CT, Plowey ED, Wang Y, Patel V, Jordan-Sciutto KL. Location, location, location: altered transcription factor trafficking in neurodegeneration. Journal of Neuropathology and Experimental Neurology. 66: 873-83. PMID 17917581 DOI: 10.1097/nen.0b013e318156a3d7  1
2007 Chu CT, Zhu J, Dagda R. Beclin 1-independent pathway of damage-induced mitophagy and autophagic stress: implications for neurodegeneration and cell death. Autophagy. 3: 663-6. PMID 17622797  1
2007 Kulich SM, Horbinski C, Patel M, Chu CT. 6-Hydroxydopamine induces mitochondrial ERK activation. Free Radical Biology & Medicine. 43: 372-83. PMID 17602953 DOI: 10.1016/j.freeradbiomed.2007.04.028  1
2007 Couce ME, Medina-Flores R, Wong M, Chu CT. Occult germ cell tumour presenting as spontaneous intracerebral haemorrhage. Histopathology. 50: 789-93. PMID 17493243 DOI: 10.1111/j.1365-2559.2007.02673.x  1
2007 Kiselyov K, Jennigs JJ, Rbaibi Y, Chu CT. Autophagy, mitochondria and cell death in lysosomal storage diseases. Autophagy. 3: 259-62. PMID 17329960  1
2007 Ramsey CP, Glass CA, Montgomery MB, Lindl KA, Ritson GP, Chia LA, Hamilton RL, Chu CT, Jordan-Sciutto KL. Expression of Nrf2 in neurodegenerative diseases. Journal of Neuropathology and Experimental Neurology. 66: 75-85. PMID 17204939 DOI: 10.1097/nen.0b013e31802d6da9  1
2007 Zhu JH, Horbinski C, Guo F, Watkins S, Uchiyama Y, Chu CT. Regulation of autophagy by extracellular signal-regulated protein kinases during 1-methyl-4-phenylpyridinium-induced cell death. The American Journal of Pathology. 170: 75-86. PMID 17200184 DOI: 10.2353/ajpath.2007.060524  1
2007 Hu D, Cao P, Thiels E, Chu CT, Wu GY, Oury TD, Klann E. Hippocampal long-term potentiation, memory, and longevity in mice that overexpress mitochondrial superoxide dismutase. Neurobiology of Learning and Memory. 87: 372-84. PMID 17129739 DOI: 10.1016/j.nlm.2006.10.003  1
2006 Jennings JJ, Zhu JH, Rbaibi Y, Luo X, Chu CT, Kiselyov K. Mitochondrial aberrations in mucolipidosis Type IV. The Journal of Biological Chemistry. 281: 39041-50. PMID 17056595 DOI: 10.1074/jbc.M607982200  1
2006 Kagan VE, Tyurina YY, Bayir H, Chu CT, Kapralov AA, Vlasova II, Belikova NA, Tyurin VA, Amoscato A, Epperly M, Greenberger J, Dekosky S, Shvedova AA, Jiang J. The "pro-apoptotic genies" get out of mitochondria: oxidative lipidomics and redox activity of cytochrome c/cardiolipin complexes. Chemico-Biological Interactions. 163: 15-28. PMID 16797512 DOI: 10.1016/j.cbi.2006.04.019  1
2006 Chalovich EM, Zhu JH, Caltagarone J, Bowser R, Chu CT. Functional repression of cAMP response element in 6-hydroxydopamine-treated neuronal cells. The Journal of Biological Chemistry. 281: 17870-81. PMID 16621793 DOI: 10.1074/jbc.M602632200  1
2005 Chu CT, Zhu JH, Cao G, Signore A, Wang S, Chen J. Apoptosis inducing factor mediates caspase-independent 1-methyl-4-phenylpyridinium toxicity in dopaminergic cells. Journal of Neurochemistry. 94: 1685-95. PMID 16156740 DOI: 10.1111/j.1471-4159.2005.03329.x  1
2005 Callio J, Oury TD, Chu CT. Manganese superoxide dismutase protects against 6-hydroxydopamine injury in mouse brains. The Journal of Biological Chemistry. 280: 18536-42. PMID 15755737 DOI: 10.1074/jbc.M413224200  1
2005 Horbinski C, Chu CT. Kinase signaling cascades in the mitochondrion: a matter of life or death. Free Radical Biology & Medicine. 38: 2-11. PMID 15589366 DOI: 10.1016/j.freeradbiomed.2004.09.030  1
2004 Chu CT, Levinthal DJ, Kulich SM, Chalovich EM, DeFranco DB. Oxidative neuronal injury. The dark side of ERK1/2. European Journal of Biochemistry / Febs. 271: 2060-6. PMID 15153095 DOI: 10.1111/j.1432-1033.2004.04132.x  1
2004 Florez-McClure ML, Linseman DA, Chu CT, Barker PA, Bouchard RJ, Le SS, Laessig TA, Heidenreich KA. The p75 neurotrophin receptor can induce autophagy and death of cerebellar Purkinje neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 4498-509. PMID 15140920 DOI: 10.1523/JNEUROSCI.5744-03.2004  1
2003 Hope C, Mettenburg J, Gonias SL, DeKosky ST, Kamboh MI, Chu CT. Functional analysis of plasma alpha(2)-macroglobulin from Alzheimer's disease patients with the A2M intronic deletion. Neurobiology of Disease. 14: 504-12. PMID 14678766 DOI: 10.1016/j.nbd.2003.08.005  1
2003 Zhu JH, Guo F, Shelburne J, Watkins S, Chu CT. Localization of phosphorylated ERK/MAP kinases to mitochondria and autophagosomes in Lewy body diseases. Brain Pathology (Zurich, Switzerland). 13: 473-81. PMID 14655753  1
2003 Beckner ME, Lee JY, Schochet SS, Chu CT. Intracranial extramedullary hematopoiesis associated with pilocytic astrocytoma: a case report. Acta Neuropathologica. 106: 584-7. PMID 14520481 DOI: 10.1007/s00401-003-0767-1  1
2003 Kulich SM, Chu CT. Role of reactive oxygen species in extracellular signal-regulated protein kinase phosphorylation and 6-hydroxydopamine cytotoxicity. Journal of Biosciences. 28: 83-9. PMID 12682429  1
2002 Zhu JH, Kulich SM, Oury TD, Chu CT. Cytoplasmic aggregates of phosphorylated extracellular signal-regulated protein kinases in Lewy body diseases. The American Journal of Pathology. 161: 2087-98. PMID 12466125 DOI: 10.1016/S0002-9440(10)64487-2  1
2001 Scarrow AM, Levy EI, Gerszten PC, Kulich SM, Chu CT, Welch WC. Epidermoid cyst of the thoracic spine: case history. Clinical Neurology and Neurosurgery. 103: 220-2. PMID 11714565 DOI: 10.1016/S0303-8467(01)00156-1  1
2001 Fattman CL, Chu CT, Kulich SM, Enghild JJ, Oury TD. Altered expression of extracellular superoxide dismutase in mouse lung after bleomycin treatment. Free Radical Biology & Medicine. 31: 1198-207. PMID 11705698 DOI: 10.1016/S0891-5849(01)00699-2  1
2001 Kulich SM, Chu CT. Sustained extracellular signal-regulated kinase activation by 6-hydroxydopamine: implications for Parkinson's disease. Journal of Neurochemistry. 77: 1058-66. PMID 11359871 DOI: 10.1046/j.1471-4159.2001.00304.x  1
2000 Thiels E, Urban NN, Gonzalez-Burgos GR, Kanterewicz BI, Barrionuevo G, Chu CT, Oury TD, Klann E. Impairment of long-term potentiation and associative memory in mice that overexpress extracellular superoxide dismutase. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 20: 7631-9. PMID 11027223  1
2000 Chu CT, Caruso JL, Cummings TJ, Ervin J, Rosenberg C, Hulette CM. Ubiquitin immunochemistry as a diagnostic aid for community pathologists evaluating patients who have dementia. Modern Pathology : An Official Journal of the United States and Canadian Academy of Pathology, Inc. 13: 420-6. PMID 10786809 DOI: 10.1038/modpathol.3880072  1
1999 Chu CT, Howell DN, Morgenlander JC, Hulette CM, McLendon RE, Miller SE. Electron microscopic diagnosis of human flavivirus encephalitis: use of confocal microscopy as an aid. The American Journal of Surgical Pathology. 23: 1217-26. PMID 10524522  1
1999 Cummings TJ, Hulette CM, Longee DC, Bottom KS, McLendon RE, Chu CT. Gliomatosis cerebri: cytologic and autopsy findings in a case involving the entire neuraxis. Clinical Neuropathology. 18: 190-7. PMID 10442461  1
1999 Cummings TJ, Chu CT, Hulette CM. December 1998--16 year old female with headaches, lethargy and a sellar/suprasellar mass. Brain Pathology (Zurich, Switzerland). 9: 425-6. PMID 10219756  1
1999 Goldstein LB, Chu CT, Gray L, Hulette CM. Angiographically defined primary angiitis of the CNS: is it really benign? Neurology. 52: 1302; author reply 1. PMID 10214774  1
1999 Mackensen GB, NellgÃ¥rd B, Miura Y, Chu CT, Dexter F, Pearlstein RD, Warner DS. Sympathetic ganglionic blockade masks beneficial effect of isoflurane on histologic outcome from near-complete forebrain ischemia in the rat. Anesthesiology. 90: 873-81. PMID 10078690  1
1998 Chu CT, Gray L, Goldstein LB, Hulette CM. Diagnosis of intracranial vasculitis: a multi-disciplinary approach. Journal of Neuropathology and Experimental Neurology. 57: 30-8. PMID 9600195  1
1996 Bradford WD, Anthony D, Chu CT, Pizzo SV. Career characteristics of graduates of a Medical Scientist Training Program, 1970-1990. Academic Medicine : Journal of the Association of American Medical Colleges. 71: 484-7. PMID 9114867  1
1996 Valnickova Z, Thogersen IB, Christensen S, Chu CT, Pizzo SV, Enghild JJ. Activated human plasma carboxypeptidase B is retained in the blood by binding to alpha2-macroglobulin and pregnancy zone protein. The Journal of Biological Chemistry. 271: 12937-43. PMID 8662763 DOI: 10.1074/jbc.271.22.12937  1
1995 Webb DJ, Hussaini IM, Weaver AM, Atkins TL, Chu CT, Pizzo SV, Owens GK, Gonias SL. Activated alpha 2-macroglobulin promotes mitogenesis in rat vascular smooth muscle cells by a mechanism that is independent of growth-factor-carrier activity. European Journal of Biochemistry / Febs. 234: 714-22. PMID 8575427  1
1995 Ren XD, Dodds AW, Enghild JJ, Chu CT, Law SK. The effect of residue 1106 on the thioester-mediated covalent binding reaction of human complement protein C4 and the monomeric rat alpha-macroglobulin alpha 1 I3. Febs Letters. 368: 87-91. PMID 7542207  1
1994 Chu CT, Pizzo SV. alpha 2-Macroglobulin, complement, and biologic defense: antigens, growth factors, microbial proteases, and receptor ligation. Laboratory Investigation; a Journal of Technical Methods and Pathology. 71: 792-812. PMID 7528831  1
1994 Chu CT, Howard GC, Misra UK, Pizzo SV. Alpha 2-macroglobulin: a sensor for proteolysis. Annals of the New York Academy of Sciences. 737: 291-307. PMID 7524403 DOI: 10.1111/j.1749-6632.1994.tb44319.x  1
1994 Misra UK, Chu CT, Gawdi G, Pizzo SV. The relationship between low density lipoprotein-related protein/alpha 2-macroglobulin (alpha 2M) receptors and the newly described alpha 2M signaling receptor. The Journal of Biological Chemistry. 269: 18303-6. PMID 7518427  1
1994 Misra UK, Chu CT, Gawdi G, Pizzo SV. Evidence for a second alpha 2-macroglobulin receptor. The Journal of Biological Chemistry. 269: 12541-7. PMID 7513689  1
1994 Chu CT, Oury TD, Enghild JJ, Pizzo SV. Adjuvant-free in vivo targeting. Antigen delivery by alpha 2-macroglobulin enhances antibody formation. Journal of Immunology (Baltimore, Md. : 1950). 152: 1538-45. PMID 7509826  1
1993 Misra UK, Chu CT, Rubenstein DS, Gawdi G, Pizzo SV. Receptor-recognized alpha 2-macroglobulin-methylamine elevates intracellular calcium, inositol phosphates and cyclic AMP in murine peritoneal macrophages. The Biochemical Journal. 290: 885-91. PMID 7681282  1
1993 Chu CT, Pizzo SV. Receptor-mediated antigen delivery into macrophages. Complexing antigen to alpha 2-macroglobulin enhances presentation to T cells. Journal of Immunology (Baltimore, Md. : 1950). 150: 48-58. PMID 7678035  1
1991 Chu CT, Pizzo SV. Interactions between cytokines and alpha 2-macroglobulin. Immunology Today. 12: 249. PMID 1716108  1
1991 Chu CT, Rubenstein DS, Enghild JJ, Pizzo SV. Mechanism of insulin incorporation into alpha 2-macroglobulin: implications for the study of peptide and growth factor binding. Biochemistry. 30: 1551-60. PMID 1704257  1
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