Davide Trotti - Publications

Neuroscience Thomas Jefferson University 
Neuroscience Biology

63 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Krishnamurthy K, Trotti D, Pasinelli P, Jensen B. Real-Time Fluorescent Measurement of Synaptic Functions in Models of Amyotrophic Lateral Sclerosis. Journal of Visualized Experiments : Jove. PMID 34338673 DOI: 10.3791/62813  1
2021 Cicardi ME, Marrone L, Azzouz M, Trotti D. Proteostatic imbalance and protein spreading in amyotrophic lateral sclerosis. The Embo Journal. e106389. PMID 33792056 DOI: 10.15252/embj.2020106389  0.01
2020 Jensen BK, Schuldi MH, McAvoy K, Russell KA, Boehringer A, Curran BM, Krishnamurthy K, Wen X, Westergard T, Ma L, Haeusler AR, Edbauer D, Pasinelli P, Trotti D. Synaptic dysfunction induced by glycine-alanine dipeptides in C9orf72-ALS/FTD is rescued by SV2 replenishment. Embo Molecular Medicine. 12: e10722. PMID 32347002 DOI: 10.15252/Emmm.201910722  1
2019 Mohamed LA, Markandaiah SS, Bonanno S, Pasinelli P, Trotti D. Excess glutamate secreted from astrocytes drives upregulation of P-glycoprotein in endothelial cells in amyotrophic lateral sclerosis. Experimental Neurology. PMID 30974102 DOI: 10.1016/J.Expneurol.2019.04.002  1
2019 Westergard T, McAvoy K, Russell K, Wen X, Pang Y, Morris B, Pasinelli P, Trotti D, Haeusler A. Repeat-associated non-AUG translation in C9orf72-ALS/FTD is driven by neuronal excitation and stress. Embo Molecular Medicine. PMID 30617154 DOI: 10.15252/Emmm.201809423  1
2018 Maimon R, Ionescu A, Bonnie A, Sweetat S, Wald-Altman S, Inbar S, Gradus T, Trotti D, Weil M, Behar O, Perlson E. miR126-5p down-regulation facilitates axon degeneration and NMJ disruption via a non-cell-autonomous mechanism in ALS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 29773756 DOI: 10.1523/Jneurosci.3037-17.2018  0.01
2018 Shi Y, Lin S, Staats KA, Li Y, Chang WH, Hung ST, Hendricks E, Linares GR, Wang Y, Son EY, Wen X, Kisler K, Wilkinson B, Menendez L, Sugawara T, ... ... Trotti D, et al. Haploinsufficiency leads to neurodegeneration in C9ORF72 ALS/FTD human induced motor neurons. Nature Medicine. PMID 29400714 DOI: 10.1038/Nm.4490  1
2018 Kia A, McAvoy K, Krishnamurthy K, Trotti D, Pasinelli P. Astrocytes expressing ALS-linked mutant FUS induce motor neuron death through release of tumor necrosis factor-alpha. Glia. PMID 29380416 DOI: 10.1002/Glia.23298  1
2017 Rosenblum LT, Trotti D. EAAT2 and the Molecular Signature of Amyotrophic Lateral Sclerosis. Advances in Neurobiology. 16: 117-136. PMID 28828608 DOI: 10.1007/978-3-319-55769-4_6  1
2017 Mohamed LA, Markandaiah S, Bonanno S, Pasinelli P, Trotti D. Blood-Brain Barrier Driven Pharmacoresistance in Amyotrophic Lateral Sclerosis and Challenges for Effective Drug Therapies. The Aaps Journal. PMID 28779378 DOI: 10.1208/S12248-017-0120-6  1
2017 Rosenblum LT, Shamamandri-Markandaiah S, Ghosh B, Foran E, Lepore AC, Pasinelli P, Trotti D. Mutation of the caspase-3 cleavage site in the astroglial glutamate transporter EAAT2 delays disease progression and extends lifespan in the SOD1-G93A mouse model of ALS. Experimental Neurology. PMID 28342750 DOI: 10.1016/J.Expneurol.2017.03.014  1
2016 Westergard T, Jensen BK, Wen X, Cai J, Kropf E, Iacovitti L, Pasinelli P, Trotti D. Cell-to-Cell Transmission of Dipeptide Repeat Proteins Linked to C9orf72-ALS/FTD. Cell Reports. 17: 645-652. PMID 27732842 DOI: 10.1016/J.Celrep.2016.09.032  1
2016 Wen X, Westergard T, Pasinelli P, Trotti D. Pathogenic determinants and mechanisms of ALS/FTD linked to hexanucleotide repeat expansions in the C9orf72 gene. Neuroscience Letters. PMID 27619540 DOI: 10.1016/J.Neulet.2016.09.007  1
2016 Qosa H, Lichter J, Sarlo M, Markandaiah SS, McAvoy K, Richard JP, Jablonski MR, Maragakis NJ, Pasinelli P, Trotti D. Astrocytes drive upregulation of the multidrug resistance transporter ABCB1 (P-Glycoprotein) in endothelial cells of the blood-brain barrier in mutant superoxide dismutase 1-linked amyotrophic lateral sclerosis. Glia. PMID 27158936 DOI: 10.1002/Glia.23003  1
2015 Qosa H, Miller DS, Pasinelli P, Trotti D. Regulation of ABC efflux transporters at blood-brain barrier in health and neurological disorders. Brain Research. PMID 26187753 DOI: 10.1016/J.Brainres.2015.07.005  1
2015 Jablonski M, Miller DS, Pasinelli P, Trotti D. ABC transporter-driven pharmacoresistance in Amyotrophic Lateral Sclerosis. Brain Research. 1607: 1-14. PMID 25175835 DOI: 10.1016/J.Brainres.2014.08.060  1
2014 Jablonski MR, Markandaiah SS, Jacob D, Meng NJ, Li K, Gennaro V, Lepore AC, Trotti D, Pasinelli P. Inhibiting drug efflux transporters improves efficacy of ALS therapeutics. Annals of Clinical and Translational Neurology. 1: 996-1005. PMID 25574474 DOI: 10.1002/Acn3.141  1
2014 Wen X, Tan W, Westergard T, Krishnamurthy K, Markandaiah SS, Shi Y, Lin S, Shneider NA, Monaghan J, Pandey UB, Pasinelli P, Ichida JK, Trotti D. Antisense proline-arginine RAN dipeptides linked to C9ORF72-ALS/FTD form toxic nuclear aggregates that initiate in vitro and in vivo neuronal death. Neuron. 84: 1213-25. PMID 25521377 DOI: 10.1016/J.Neuron.2014.12.010  1
2014 Foran E, Rosenblum L, Bogush A, Pasinelli P, Trotti D. Sumoylation of the astroglial glutamate transporter EAAT2 governs its intracellular compartmentalization. Glia. 62: 1241-53. PMID 24753081 DOI: 10.1002/Glia.22677  1
2014 Tan W, Pasinelli P, Trotti D. Role of mitochondria in mutant SOD1 linked amyotrophic lateral sclerosis. Biochimica Et Biophysica Acta. 1842: 1295-301. PMID 24568860 DOI: 10.1016/J.Bbadis.2014.02.009  1
2013 Foran E, Rosenblum L, Bogush AI, Trotti D. Sumoylation of critical proteins in amyotrophic lateral sclerosis: emerging pathways of pathogenesis. Neuromolecular Medicine. 15: 760-70. PMID 24062161 DOI: 10.1007/S12017-013-8262-X  1
2013 Tan W, Naniche N, Bogush A, Pedrini S, Trotti D, Pasinelli P. Small peptides against the mutant SOD1/Bcl-2 toxic mitochondrial complex restore mitochondrial function and cell viability in mutant SOD1-mediated ALS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 11588-98. PMID 23843527 DOI: 10.1523/Jneurosci.5385-12.2013  1
2012 Jablonski MR, Jacob DA, Campos C, Miller DS, Maragakis NJ, Pasinelli P, Trotti D. Selective increase of two ABC drug efflux transporters at the blood-spinal cord barrier suggests induced pharmacoresistance in ALS. Neurobiology of Disease. 47: 194-200. PMID 22521463 DOI: 10.1016/J.Nbd.2012.03.040  1
2012 Guareschi S, Cova E, Cereda C, Ceroni M, Donetti E, Bosco DA, Trotti D, Pasinelli P. An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1. Proceedings of the National Academy of Sciences of the United States of America. 109: 5074-9. PMID 22416121 DOI: 10.1073/Pnas.1115402109  1
2011 Foran E, Bogush A, Goffredo M, Roncaglia P, Gustincich S, Pasinelli P, Trotti D. Motor neuron impairment mediated by a sumoylated fragment of the glial glutamate transporter EAAT2. Glia. 59: 1719-31. PMID 21769946 DOI: 10.1002/Glia.21218  1
2010 Fieni F, Parkar A, Misgeld T, Kerschensteiner M, Lichtman JW, Pasinelli P, Trotti D. Voltage-dependent inwardly rectifying potassium conductance in the outer membrane of neuronal mitochondria. The Journal of Biological Chemistry. 285: 27411-7. PMID 20551319 DOI: 10.1074/Jbc.M110.131243  1
2010 Pedrini S, Sau D, Guareschi S, Bogush M, Brown RH, Naniche N, Kia A, Trotti D, Pasinelli P. ALS-linked mutant SOD1 damages mitochondria by promoting conformational changes in Bcl-2. Human Molecular Genetics. 19: 2974-86. PMID 20460269 DOI: 10.1093/Hmg/Ddq202  1
2009 Foran E, Trotti D. Glutamate transporters and the excitotoxic path to motor neuron degeneration in amyotrophic lateral sclerosis. Antioxidants & Redox Signaling. 11: 1587-602. PMID 19413484 DOI: 10.1089/Ars.2009.2444  1
2008 Boston-Howes W, Williams EO, Bogush A, Scolere M, Pasinelli P, Trotti D. Nordihydroguaiaretic acid increases glutamate uptake in vitro and in vivo: therapeutic implications for amyotrophic lateral sclerosis. Experimental Neurology. 213: 229-37. PMID 18625223 DOI: 10.1016/J.Expneurol.2008.06.010  1
2007 Gibb SL, Boston-Howes W, Lavina ZS, Gustincich S, Brown RH, Pasinelli P, Trotti D. A caspase-3-cleaved fragment of the glial glutamate transporter EAAT2 is sumoylated and targeted to promyelocytic leukemia nuclear bodies in mutant SOD1-linked amyotrophic lateral sclerosis. The Journal of Biological Chemistry. 282: 32480-90. PMID 17823119 DOI: 10.1074/Jbc.M704314200  1
2006 Boston-Howes W, Gibb SL, Williams EO, Pasinelli P, Brown RH, Trotti D. Caspase-3 cleaves and inactivates the glutamate transporter EAAT2. The Journal of Biological Chemistry. 281: 14076-84. PMID 16567804 DOI: 10.1074/Jbc.M600653200  1
2004 Pasinelli P, Belford ME, Lennon N, Bacskai BJ, Hyman BT, Trotti D, Brown RH. Amyotrophic lateral sclerosis-associated SOD1 mutant proteins bind and aggregate with Bcl-2 in spinal cord mitochondria. Neuron. 43: 19-30. PMID 15233914 DOI: 10.1016/J.Neuron.2004.06.021  1
2004 Marciani P, Trotti D, Hediger MA, Monticelli G. Modulation of DMT1 Activity by Redox Compounds Journal of Membrane Biology. 197: 91-99. PMID 15014911 DOI: 10.1007/s00232-003-0644-9  1
2002 Trotti D. A role for glutamate transporters in neurodegenerative diseases. Advances in Experimental Medicine and Biology. 513: 225-48. PMID 12575823  1
2001 Trotti D, Peng JB, Dunlop J, Hediger MA. Inhibition of the glutamate transporter EAAC1 expressed in Xenopus oocytes by phorbol esters Brain Research. 914: 196-203. PMID 11578612 DOI: 10.1016/S0006-8993(01)02802-5  1
2001 Gegelashvili G, Robinson MB, Trotti D, Rauen T. Regulation of glutamate transporters in health and disease. Progress in Brain Research. 132: 267-86. PMID 11544995 DOI: 10.1016/S0079-6123(01)32082-4  1
2001 Trotti D, Aoki M, Pasinelli P, Berger UV, Danbolt NC, Brown RH, Hediger MA. Amyotrophic lateral sclerosis-linked glutamate transporter mutant has impaired glutamate clearance capacity Journal of Biological Chemistry. 276: 576-582. PMID 11031254 DOI: 10.1074/Jbc.M003779200  1
2001 Sacchi VF, Castagna M, Trotti D, Shayakul C, Hediger MA. Neutral amino acid absorption in the midgut of lepidopteran larvae Advances in Insect Physiology. 28: 168-184. DOI: 10.1016/S0065-2806(01)28010-2  1
2000 Cunnane SC, Trotti D, Ryan MA. Specific linoleate deficiency in the rat does not prevent substantial carbon recycling from [14C]linoleate into sterols Journal of Lipid Research. 41: 1808-1811. PMID 11060350  1
1999 Civenni G, Bezzi P, Trotti D, Volterra A, Racagni G. Inhibitory effect of the neuroprotective agent idebenone on arachidonic acid metabolism in astrocytes. European Journal of Pharmacology. 370: 161-7. PMID 10323265 DOI: 10.1016/S0014-2999(99)00127-2  1
1999 Trotti D, Rolfs A, Danbolt NC, Brown RH, Hediger MA. SOD1 mutants linked to amyotrophic lateral sclerosis selectively inactivate a glial glutamate transporter Nature Neuroscience. 2: 427-433. PMID 10321246 DOI: 10.1038/8091  1
1998 Trotti D, Danbolt NC, Volterra A. Glutamate transporters are oxidant-vulnerable: A molecular link between oxidative and excitotoxic neurodegeneration? Trends in Pharmacological Sciences. 19: 328-334. PMID 9745361 DOI: 10.1016/S0165-6147(98)01230-9  1
1998 Castagna M, Shayakul C, Trotti D, Sacchi VF, Harvey WR, Hediger MA. Cloning and characterization of a potassium-coupled amino acid transporter. Proceedings of the National Academy of Sciences of the United States of America. 95: 5395-400. PMID 9560287 DOI: 10.1073/pnas.95.9.5395  1
1998 Peng JB, Chen XZ, Trotti D, Hediger MA. Mutations of amino acid residues that alter the chloride conductance of the human neuronal glutamate transporter EAAC1 Faseb Journal. 12.  1
1997 Trotti D. Short communication differential modulation of the uptake currents by redox interconversion of cysteine residues in the human neuronal glutamate transporter EAAC1 European Journal of Neuroscience. 9: 2207-2212. PMID 9421181 DOI: 10.1111/J.1460-9568.1997.Tb01388.X  1
1997 Coco S, Verderio C, Trotti D, Rothstein JD, Volterra A, Matteoli M. Non-synaptic localization of the glutamate transporter EAAC1 in cultured hippocampal neurons. The European Journal of Neuroscience. 9: 1902-10. PMID 9383213 DOI: 10.1111/J.1460-9568.1997.Tb00757.X  1
1997 Trotti D, Rizzini BL, Rossi D, Haugeto O, Racagni G, Danbolt NC, Volterra A. Neuronal and glial glutamate transporters possess an SH-based redox regulatory mechanism European Journal of Neuroscience. 9: 1236-1243. PMID 9215707 DOI: 10.1111/J.1460-9568.1997.Tb01478.X  1
1997 Nussberger S, Steel A, Trottif D, Romero MF, Boron WF, Hediger MA. Symmetry of H+ binding to the intra- and extracellular side of the H+- coupled oligopeptide cotransporter PepT1 Journal of Biological Chemistry. 272: 7777-7785. PMID 9065440 DOI: 10.1074/Jbc.272.12.7777  0.52
1997 Castagna M, Shayakul C, Trotti D, Sacchi VF, Harvey WR, Hediger MA. Molecular characteristics of mammalian and insect amino acid transporters: implications for amino acid homeostasis. The Journal of Experimental Biology. 200: 269-86. PMID 9050235  1
1997 Castagna M, Shayakul C, Trotti D, Sacchi VF, Harvey WR, Hediger MA. Expression cloning of a K+-coupled amino acid transporter (KAAT1) from lepidopteran larval intestine Faseb Journal. 11: A31.  1
1996 Volterra A, Bezzi P, Rizzini BL, Trotti D, Ullensvang K, Danbolt NC, Racagni G. The competitive transport inhibitor L-trans-pyrrolidine-2, 4-dicarboxylate triggers excitotoxicity in rat cortical neuron-astrocyte co-cultures via glutamate release rather than uptake inhibition. The European Journal of Neuroscience. 8: 2019-28. PMID 8921292 DOI: 10.1111/J.1460-9568.1996.Tb01345.X  1
1996 Trotti D, Rossi D, Gjesdal O, Levy LM, Racagni G, Danbolt NC, Volterra A. Peroxynitrite inhibits glutamate transporter subtypes Journal of Biological Chemistry. 271: 5976-5979. PMID 8626378 DOI: 10.1074/Jbc.271.11.5976  1
1995 Volterra A, Trotti D, Bezzi P, Civenni G, Racagni G. [Ca2+] modulates the ratio between cycloxygenase and lipoxygenase metabolism of arachidonic acid in homogenates of hippocampal astroglial cultures. Neuroscience Letters. 183: 160-3. PMID 7739784 DOI: 10.1016/0304-3940(94)11140-E  1
1995 Trotti D, Volterra A, Lehre KP, Rossi D, Gjesdal O, Racagni G, Danbolt NC. Arachidonic acid inhibits a purified and reconstituted glutamate transporter directly from the water phase and not via the phospholipid membrane Journal of Biological Chemistry. 270: 9890-9895. PMID 7730372 DOI: 10.1074/Jbc.270.17.9890  1
1994 Volterra A, Trotti D, Racagni G. Glutamate uptake is inhibited by arachidonic acid and oxygen radicals via two distinct and additive mechanisms Molecular Pharmacology. 46: 986-992. PMID 7969090  1
1994 Volterra A, Trotti D, Tromba C, Floridi S, Racagni G. Glutamate uptake inhibition by oxygen free radicals in rat cortical astrocytes Journal of Neuroscience. 14: 2924-2932. PMID 7910203 DOI: 10.1523/Jneurosci.14-05-02924.1994  1
1994 Volterra A, Trotti D, Floridi S, Racagni G. Reactive oxygen species inhibit high-affinity glutamate uptake: Molecular mechanism and neuropathological implications Annals of the New York Academy of Sciences. 738: 153-162. PMID 7832426 DOI: 10.1111/J.1749-6632.1994.Tb21800.X  1
1994 Racagni G, Riva M, Trotti D, Volterra A. Modulation of glutamate uptake by oxygen free radicals and changes in the expression of NMDA receptor subunits: relevance to neurotoxicity European Neuropsychopharmacology. 4: 261-262. DOI: 10.1016/0924-977X(94)90081-7  1
1993 Volterra A, Trotti D, Floridi S, Mazza F, Racagni G. Inhibition of high-affinity glutamate uptake by arachidonic acid and oxygen free radicals: physiopathological significance European Neuropsychopharmacology. 3: 182-183. DOI: 10.1016/0924-977X(93)90014-D  1
1992 Volterra A, Trotti D, Cassutti P, Tromba C, Salvaggio A, Melcangi RC, Racagni G. High sensitivity of glutamate uptake to extracellular free arachidonic acid levels in rat cortical synaptosomes and astrocytes Journal of Neurochemistry. 59: 600-606. PMID 1629731 DOI: 10.1111/J.1471-4159.1992.Tb09411.X  1
1992 Volterra A, Trotti D, Cassutti P, Tromba C, Galimberti R, Lecchi P, Racagni G. A role for the arachidonic acid cascade in fast synaptic modulation: Ion channels and transmitter uptake systems as target proteins Advances in Experimental Medicine and Biology. 318: 147-158. PMID 1378992 DOI: 10.1007/978-1-4615-3426-6_13  1
1992 Volterra A, Trotti D, Floridi S, Mazza F, Racagni G. NMDA-mediated arachidonic acid release: An intercellular coordinator mechanism for the modulation of glutamatergic synaptic efficacy Pharmacological Research. 26: 105.  1
1988 Brunello N, Rovescalli AC, Perez J, Tinelli D, Trotti D, Cuomo V, Racagni G. Receptor mediated responses and intracellular mechanisms after antidepressant treatment Pharmacological Research Communications. 20: 58. DOI: 10.1016/S0031-6989(88)80188-7  1
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