Jeffrey D. Rothstein - Publications

Johns Hopkins University, Baltimore, MD 
Transporter, ALS

225 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Shefner JM, Bedlack R, Andrews JA, Berry JD, Bowser R, Brown R, Glass JD, Maragakis NJ, Miller TM, Rothstein JD, Cudkowicz ME. Amyotrophic Lateral Sclerosis Clinical Trials and Interpretation of Functional End Points and Fluid Biomarkers: A Review. Jama Neurology. PMID 36251310 DOI: 10.1001/jamaneurol.2022.3282  0.513
2022 Maragakis NJ, Rothstein JD. The Evolving Landscape of Motor Neuron Disease Therapeutics. Neurotherapeutics : the Journal of the American Society For Experimental Neurotherapeutics. PMID 36171516 DOI: 10.1007/s13311-022-01307-7  0.589
2022 Baxi EG, Thompson T, Li J, Kaye JA, Lim RG, Wu J, Ramamoorthy D, Lima L, Vaibhav V, Matlock A, Frank A, Coyne AN, Landin B, Ornelas L, Mosmiller E, ... ... Rothstein JD, et al. Answer ALS, a large-scale resource for sporadic and familial ALS combining clinical and multi-omics data from induced pluripotent cell lines. Nature Neuroscience. 25: 226-237. PMID 35115730 DOI: 10.1038/s41593-021-01006-0  0.569
2021 Li J, Lim RG, Kaye JA, Dardov V, Coyne AN, Wu J, Milani P, Cheng A, Thompson TG, Ornelas L, Frank A, Adam M, Banuelos MG, Casale M, ... ... Rothstein JD, et al. An integrated multi-omic analysis of iPSC-derived motor neurons from C9ORF72 ALS patients. Iscience. 24: 103221. PMID 34746695 DOI: 10.1016/j.isci.2021.103221  0.307
2021 Johnson JO, Chia R, Miller DE, Li R, Kumaran R, Abramzon Y, Alahmady N, Renton AE, Topp SD, Gibbs JR, Cookson MR, Sabir MS, Dalgard CL, Troakes C, Jones AR, ... ... Rothstein JD, et al. Association of Variants in the SPTLC1 Gene With Juvenile Amyotrophic Lateral Sclerosis. Jama Neurology. PMID 34459874 DOI: 10.1001/jamaneurol.2021.2598  0.535
2021 Coyne AN, Baskerville V, Zaepfel BL, Dickson DW, Rigo F, Bennett F, Lusk CP, Rothstein JD. Nuclear accumulation of CHMP7 initiates nuclear pore complex injury and subsequent TDP-43 dysfunction in sporadic and familial ALS. Science Translational Medicine. 13. PMID 34321318 DOI: 10.1126/scitranslmed.abe1923  0.341
2020 Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, Harel A, Svendsen CN, Sareen D, Rothstein JD. GC Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD. Neuron. PMID 32673563 DOI: 10.1016/J.Neuron.2020.06.027  0.425
2020 Andrews JA, Berry JD, Baloh RH, Carberry N, Cudkowicz ME, Dedi B, Glass J, Maragakis NJ, Miller TM, Paganoni S, Rothstein JD, Shefner JM, Simmons Z, Weiss MD, Bedlack RS. Amyotrophic Lateral Sclerosis Care and Research in the USA During the COVID-19 Pandemic: Challenges and Opportunities. Muscle & Nerve. PMID 32445195 DOI: 10.1002/Mus.26989  0.562
2020 Hayes LR, Duan L, Bowen K, Kalab P, Rothstein JD. arginine-rich dipeptide repeat proteins disrupt karyopherin-mediated nuclear import. Elife. 9. PMID 32119645 DOI: 10.7554/eLife.51685  0.323
2020 Westergard T, Rothstein JD. Astrocyte Diversity: Current Insights and Future Directions. Neurochemical Research. PMID 32006215 DOI: 10.1007/s11064-020-02959-7  0.34
2019 Agurto C, Ahmad O, Cecchi GA, Norel R, Pietrowicz M, Eyigoz EK, Mosmiller E, Baxi E, Rothstein JD, Roy P, Berry J, Maragakis NJ. Analyzing progression of motor and speech impairment in ALS. Conference Proceedings : ... Annual International Conference of the Ieee Engineering in Medicine and Biology Society. Ieee Engineering in Medicine and Biology Society. Annual Conference. 2019: 6097-6102. PMID 31947236 DOI: 10.1109/EMBC.2019.8857300  0.566
2019 Cheng W, Wang S, Zhang Z, Morgens DW, Hayes LR, Lee S, Portz B, Xie Y, Nguyen BV, Haney MS, Yan S, Dong D, Coyne AN, Yang J, Xian F, ... ... Rothstein JD, et al. CRISPR-Cas9 Screens Identify the RNA Helicase DDX3X as a Repressor of C9ORF72 (GGGGCC)n Repeat-Associated Non-AUG Translation. Neuron. PMID 31587919 DOI: 10.1016/J.Neuron.2019.09.003  0.322
2019 Katt ME, Mayo LN, Ellis SE, Mahairaki V, Rothstein JD, Cheng L, Searson PC. The role of mutations associated with familial neurodegenerative disorders on blood-brain barrier function in an iPSC model. Fluids and Barriers of the Cns. 16: 20. PMID 31303172 DOI: 10.1186/S12987-019-0139-4  0.323
2019 Savchenko E, Teku GN, Boza-Serrano A, Russ K, Berns M, Deierborg T, Lamas NJ, Wichterle H, Rothstein J, Henderson CE, Vihinen M, Roybon L. FGF family members differentially regulate maturation and proliferation of stem cell-derived astrocytes. Scientific Reports. 9: 9610. PMID 31270389 DOI: 10.1038/S41598-019-46110-1  0.372
2019 Miller SJ, Philips T, Kim N, Dastgheyb R, Chen Z, Hsieh YC, Daigle JG, Datta M, Chew J, Vidensky S, Pham JT, Hughes EG, Robinson MB, Sattler R, Tomer R, ... ... Rothstein JD, et al. Molecularly defined cortical astroglia subpopulation modulates neurons via secretion of Norrin. Nature Neuroscience. PMID 30936556 DOI: 10.1038/S41593-019-0366-7  0.38
2019 Chew J, Cook C, Gendron TF, Jansen-West K, Del Rosso G, Daughrity LM, Castanedes-Casey M, Kurti A, Stankowski JN, Disney MD, Rothstein JD, Dickson DW, Fryer JD, Zhang YJ, Petrucelli L. Aberrant deposition of stress granule-resident proteins linked to C9orf72-associated TDP-43 proteinopathy. Molecular Neurodegeneration. 14: 9. PMID 30767771 DOI: 10.1186/S13024-019-0310-Z  0.305
2019 Eftekharzadeh B, Daigle JG, Kapinos LE, Coyne A, Schiantarelli J, Carlomagno Y, Cook C, Miller SJ, Dujardin S, Amaral AS, Grima JC, Bennett RE, Tepper K, DeTure M, Vanderburg CR, ... ... Rothstein JD, et al. Tau Protein Disrupts Nucleocytoplasmic Transport in Alzheimer's Disease. Neuron. 101: 349. PMID 30653936 DOI: 10.1016/J.Neuron.2018.12.031  0.3
2018 Miller SJ, Glatzer JC, Hsieh YC, Rothstein JD. Cortical astroglia undergo transcriptomic dysregulation in the G93A SOD1 ALS mouse model. Journal of Neurogenetics. 1-14. PMID 30398075 DOI: 10.1080/01677063.2018.1513508  0.436
2018 Hoye ML, Regan MR, Jensen LA, Lake AM, Reddy LV, Vidensky S, Richard JP, Maragakis NJ, Rothstein JD, Dougherty JD, Miller TM. Motor neuron-derived microRNAs cause astrocyte dysfunction in amyotrophic lateral sclerosis. Brain : a Journal of Neurology. PMID 30007309 DOI: 10.1093/Brain/Awy182  0.612
2018 Perkins EM, Clarkson YL, Suminaite D, Lyndon AR, Tanaka K, Rothstein JD, Skehel P, Wyllie DJA, Jackson M. Loss of cerebellar glutamate transporters EAAT4 and GLAST differentially affects the spontaneous firing pattern and survival of Purkinje cells. Human Molecular Genetics. PMID 29741614 DOI: 10.1093/hmg/ddy169  0.429
2018 Zhang K, Daigle JG, Cunningham KM, Coyne AN, Ruan K, Grima JC, Bowen KE, Wadhwa H, Yang P, Rigo F, Taylor JP, Gitler AD, Rothstein JD, Lloyd TE. Stress Granule Assembly Disrupts Nucleocytoplasmic Transport. Cell. PMID 29628143 DOI: 10.1016/J.Cell.2018.03.025  0.355
2018 Nicolas A, Kenna KP, Renton AE, Ticozzi N, Faghri F, Chia R, Dominov JA, Kenna BJ, Nalls MA, Keagle P, Rivera AM, van Rheenen W, Murphy NA, van Vugt JJFA, Geiger JT, ... ... Rothstein JD, et al. Genome-wide Analyses Identify KIF5A as a Novel ALS Gene. Neuron. 97: 1268-1283.e6. PMID 29566793 DOI: 10.1016/J.Neuron.2018.02.027  0.552
2017 Philips T, Rothstein JD. Oligodendroglia: metabolic supporters of neurons. The Journal of Clinical Investigation. 127: 3271-3280. PMID 28862639 DOI: 10.1172/JCI90610  0.352
2017 Zhang K, Rothstein JD. Neurodegenerative disease: Two-for-one on potential therapies. Nature. PMID 28405020 DOI: 10.1038/Nature21911  0.403
2017 Grima JC, Daigle JG, Arbez N, Cunningham KC, Zhang K, Ochaba J, Geater C, Morozko E, Stocksdale J, Glatzer JC, Pham JT, Ahmed I, Peng Q, Wadhwa H, Pletnikova O, ... ... Rothstein JD, et al. Mutant Huntingtin Disrupts the Nuclear Pore Complex. Neuron. 94: 93-107.e6. PMID 28384479 DOI: 10.1016/J.Neuron.2017.03.023  0.392
2017 Gendron TF, Chew J, Stankowski JN, Hayes LR, Zhang YJ, Prudencio M, Carlomagno Y, Daughrity LM, Jansen-West K, Perkerson EA, O'Raw A, Cook C, Pregent L, Belzil V, van Blitterswijk M, ... ... Rothstein JD, et al. Poly(GP) proteins are a useful pharmacodynamic marker for C9ORF72-associated amyotrophic lateral sclerosis. Science Translational Medicine. 9. PMID 28356511 DOI: 10.1126/Scitranslmed.Aai7866  0.328
2017 Peschansky V, Bedlack R, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, ... ... Rothstein J, et al. ALSUntangled 38: L-serine Amyotrophic Lateral Sclerosis. 18: 148-151. PMID 27894192 DOI: 10.1080/21678421.2016.1250353  0.513
2017 Bedlack R, Fixsen E, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, ... ... Rothstein J, et al. ALSUntangled No. 36: Accilion Amyotrophic Lateral Sclerosis. 18: 142-147. PMID 27685025 DOI: 10.1080/21678421.2016.1215400  0.563
2016 Perkins EM, Suminaite D, Clarkson YL, Lee SK, Lyndon AR, Rothstein JD, Wyllie DJ, Tanaka K, Jackson M. Posterior cerebellar Purkinje cells in an SCA5/SPARCA1 mouse model are especially vulnerable to the synergistic effect of loss of β-III spectrin and GLAST. Human Molecular Genetics. 25: 4448-4461. PMID 28173092 DOI: 10.1093/hmg/ddw274  0.337
2016 Miller SJ, Zhang PW, Glatzer J, Rothstein JD. Astroglial transcriptome dysregulation in early disease of an ALS mutant SOD1 mouse model. Journal of Neurogenetics. 1-12. PMID 28019127 DOI: 10.1080/01677063.2016.1260128  0.388
2016 Le NT, Chang L, Kovlyagina I, Georgiou P, Safren N, Braunstein KE, Kvarta MD, Van Dyke AM, LeGates TA, Philips T, Morrison BM, Thompson SM, Puche AC, Gould TD, Rothstein JD, et al. Motor neuron disease, TDP-43 pathology, and memory deficits in mice expressing ALS-FTD-linked UBQLN2 mutations. Proceedings of the National Academy of Sciences of the United States of America. PMID 27834214 DOI: 10.1073/Pnas.1608432113  0.439
2016 Ehmsen JT, Liu Y, Wang Y, Paladugu N, Johnson AE, Rothstein JD, du Lac S, Mattson MP, Höke A. The astrocytic transporter SLC7A10 (Asc-1) mediates glycinergic inhibition of spinal cord motor neurons. Scientific Reports. 6: 35592. PMID 27759100 DOI: 10.1038/Srep35592  0.424
2016 Miller SJ, Rothstein JD. Astroglia in Thick Tissue with Super Resolution and Cellular Reconstruction. Plos One. 11: e0160391. PMID 27494718 DOI: 10.1371/journal.pone.0160391  0.335
2016 Choi IY, Lim H, Estrellas K, Mula J, Cohen TV, Zhang Y, Donnelly CJ, Richard JP, Kim YJ, Kim H, Kazuki Y, Oshimura M, Li HL, Hotta A, Rothstein J, et al. Concordant but Varied Phenotypes among Duchenne Muscular Dystrophy Patient-Specific Myoblasts Derived using a Human iPSC-Based Model. Cell Reports. PMID 27239027 DOI: 10.1016/J.Celrep.2016.05.016  0.573
2016 Hayes LR, Rothstein JD. C9ORF72-ALS/FTD: Transgenic Mice Make a Come-BAC. Neuron. 90: 427-31. PMID 27151634 DOI: 10.1016/j.neuron.2016.04.026  0.307
2016 Haeusler AR, Donnelly CJ, Rothstein JD. The expanding biology of the C9orf72 nucleotide repeat expansion in neurodegenerative disease. Nature Reviews. Neuroscience. PMID 27150398 DOI: 10.1038/Nrn.2016.38  0.305
2016 Fixsen E, Bedlack R, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, ... ... Rothstein J, et al. ALSUntangled No. 35: Hyperbaric Oxygen Therapy* Amyotrophic Lateral Sclerosis. 17: 622-624. PMID 27089115 DOI: 10.3109/21678421.2016.1172818  0.511
2016 Bedlack R, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, ... ... Rothstein J, et al. ALSUntangled No. 34: GM604 Amyotrophic Lateral Sclerosis. 17: 617-621. PMID 27043278 DOI: 10.3109/21678421.2016.1164940  0.513
2016 Zhang YJ, Gendron TF, Grima JC, Sasaguri H, Jansen-West K, Xu YF, Katzman RB, Gass J, Murray ME, Shinohara M, Lin WL, Garrett A, Stankowski JN, Daughrity L, Tong J, ... ... Rothstein JD, et al. C9ORF72 poly(GA) aggregates sequester and impair HR23 and nucleocytoplasmic transport proteins. Nature Neuroscience. PMID 26998601 DOI: 10.1038/Nn.4272  0.312
2015 Ghosh M, Lane M, Krizman E, Sattler R, Rothstein JD, Robinson MB. Transcription Factor Pax6 Contributes to Induction of GLT-1 Expression in Astrocytes Through an Interaction with a Distal Enhancer Element. Journal of Neurochemistry. PMID 26485579 DOI: 10.1111/Jnc.13406  0.401
2015 Li W, Lee MH, Henderson L, Tyagi R, Bachani M, Steiner J, Campanac E, Hoffman DA, von Geldern G, Johnson K, Maric D, Morris HD, Lentz M, Pak K, Mammen A, ... ... Rothstein J, et al. Human endogenous retrovirus-K contributes to motor neuron disease. Science Translational Medicine. 7: 307ra153. PMID 26424568 DOI: 10.1126/Scitranslmed.Aac8201  0.421
2015 Philips T, Rothstein JD. Rodent Models of Amyotrophic Lateral Sclerosis. Current Protocols in Pharmacology / Editorial Board, S.J. Enna (Editor-in-Chief) ... [Et Al.]. 69: 5.67.1-5.67.21. PMID 26344214 DOI: 10.1002/0471141755.ph0567s69  0.431
2015 Zhang K, Donnelly CJ, Haeusler AR, Grima JC, Machamer JB, Steinwald P, Daley EL, Miller SJ, Cunningham KM, Vidensky S, Gupta S, Thomas MA, Hong I, Chiu SL, Huganir RL, ... ... Rothstein JD, et al. The C9orf72 repeat expansion disrupts nucleocytoplasmic transport. Nature. 525: 56-61. PMID 26308891 DOI: 10.1038/Nature14973  0.42
2015 Zhang PW, Haidet-Phillips AM, Pham JT, Lee Y, Huo Y, Tienari PJ, Maragakis NJ, Sattler R, Rothstein JD. Generation of GFAP::GFP astrocyte reporter lines from human adult fibroblast-derived iPS cells using zinc-finger nuclease technology. Glia. PMID 26295203 DOI: 10.1002/Glia.22903  0.638
2015 Li Y, Balasubramanian U, Cohen D, Zhang PW, Mosmiller E, Sattler R, Maragakis NJ, Rothstein JD. A comprehensive library of familial human amyotrophic lateral sclerosis induced pluripotent stem cells. Plos One. 10: e0118266. PMID 25760436 DOI: 10.1371/Journal.Pone.0118266  0.625
2015 Bedlack R, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, ... ... Rothstein J, et al. ALSUntangled No. 29: MitoQ Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16: 427-429. DOI: 10.3109/21678421.2015.1050897  0.517
2015 Bedlack R, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, ... ... Rothstein J, et al. ALSUntangled: Introducing the table of evidence Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 16: 142-145. DOI: 10.3109/21678421.2014.987476  0.523
2014 Al-Sarraj S, King A, Cleveland M, Pradat PF, Corse A, Rothstein JD, Leigh PN, Abila B, Bates S, Wurthner J, Meininger V. Mitochondrial abnormalities and low grade inflammation are present in the skeletal muscle of a minority of patients with amyotrophic lateral sclerosis; an observational myopathology study. Acta Neuropathologica Communications. 2: 165. PMID 25510661 DOI: 10.1186/s40478-014-0165-z  0.404
2014 Cudkowicz ME, Titus S, Kearney M, Yu H, Sherman A, Schoenfeld D, Hayden D, Shui A, Brooks B, Conwit R, Felsenstein D, Greenblatt DJ, Keroack M, Kissel JT, Miller R, ... ... Rothstein JD, et al. Safety and efficacy of ceftriaxone for amyotrophic lateral sclerosis: a multi-stage, randomised, double-blind, placebo-controlled trial. The Lancet. Neurology. 13: 1083-91. PMID 25297012 DOI: 10.1016/S1474-4422(14)70222-4  0.333
2014 Vucic S, Rothstein JD, Kiernan MC. Advances in treating amyotrophic lateral sclerosis: insights from pathophysiological studies. Trends in Neurosciences. 37: 433-42. PMID 24927875 DOI: 10.1016/j.tins.2014.05.006  0.351
2014 Philips T, Rothstein JD. Glial cells in amyotrophic lateral sclerosis. Experimental Neurology. 262: 111-20. PMID 24859452 DOI: 10.1016/j.expneurol.2014.05.015  0.392
2014 Johnson JO, Pioro EP, Boehringer A, Chia R, Feit H, Renton AE, Pliner HA, Abramzon Y, Marangi G, Winborn BJ, Gibbs JR, Nalls MA, Morgan S, Shoai M, Hardy J, ... ... Rothstein JD, et al. Mutations in the Matrin 3 gene cause familial amyotrophic lateral sclerosis. Nature Neuroscience. 17: 664-6. PMID 24686783 DOI: 10.1038/Nn.3688  0.378
2014 Haeusler AR, Donnelly CJ, Periz G, Simko EA, Shaw PG, Kim MS, Maragakis NJ, Troncoso JC, Pandey A, Sattler R, Rothstein JD, Wang J. C9orf72 nucleotide repeat structures initiate molecular cascades of disease. Nature. 507: 195-200. PMID 24598541 DOI: 10.1038/Nature13124  0.584
2014 Butovsky O, Jedrychowski MP, Moore CS, Cialic R, Lanser AJ, Gabriely G, Koeglsperger T, Dake B, Wu PM, Doykan CE, Fanek Z, Liu L, Chen Z, Rothstein JD, Ransohoff RM, et al. Identification of a unique TGF-β-dependent molecular and functional signature in microglia. Nature Neuroscience. 17: 131-43. PMID 24316888 DOI: 10.1038/Nn.3599  0.343
2014 Bedlack R, Quinn C, Karam C, Sherman A, Ostrow L, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, ... ... Rothstein J, et al. ALSUntangled no. 26: Lunasin Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration. 15: 622-626. DOI: 10.3109/21678421.2014.959297  0.497
2013 Zu T, Liu Y, Bañez-Coronel M, Reid T, Pletnikova O, Lewis J, Miller TM, Harms MB, Falchook AE, Subramony SH, Ostrow LW, Rothstein JD, Troncoso JC, Ranum LP. RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America. 110: E4968-77. PMID 24248382 DOI: 10.1073/Pnas.1315438110  0.37
2013 Donnelly CJ, Zhang PW, Pham JT, Haeusler AR, Heusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, ... ... Rothstein JD, et al. RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron. 80: 415-28. PMID 24139042 DOI: 10.1016/J.Neuron.2013.10.015  0.615
2013 Roybon L, Lamas NJ, Garcia-Diaz A, Yang EJ, Sattler R, Jackson-Lewis V, Kim YA, Kachel CA, Rothstein JD, Przedborski S, Wichterle H, Henderson CE. Human stem cell-derived spinal cord astrocytes with defined mature or reactive phenotypes. Cell Reports. 4: 1035-48. PMID 23994478 DOI: 10.1016/J.Celrep.2013.06.021  0.345
2013 Sattler R, Tyler B, Hoover B, Coddington LT, Recinos V, Hwang L, Brem H, Rothstein JD. Increased expression of glutamate transporter GLT-1 in peritumoral tissue associated with prolonged survival and decreases in tumor growth in a rat model of experimental malignant glioma. Journal of Neurosurgery. 119: 878-86. PMID 23909244 DOI: 10.3171/2013.6.Jns122319  0.411
2013 Ravits J, Appel S, Baloh RH, Barohn R, Brooks BR, Elman L, Floeter MK, Henderson C, Lomen-Hoerth C, Macklis JD, McCluskey L, Mitsumoto H, Przedborski S, Rothstein J, Trojanowski JQ, et al. Deciphering amyotrophic lateral sclerosis: what phenotype, neuropathology and genetics are telling us about pathogenesis. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 5-18. PMID 23678876 DOI: 10.3109/21678421.2013.778548  0.415
2013 Fournier C, Bedlack B, Hardiman O, Heiman-Patterson T, Gutmann L, Bromberg M, Ostrow L, Carter G, Kabashi E, Bertorini T, Mozaffar T, Andersen P, Dietz J, Gamez J, ... ... Rothstein J, et al. ALS Untangled No. 20: the Deanna protocol. Amyotrophic Lateral Sclerosis & Frontotemporal Degeneration. 14: 319-23. PMID 23638638 DOI: 10.3109/21678421.2013.788405  0.565
2013 Kang SH, Li Y, Fukaya M, Lorenzini I, Cleveland DW, Ostrow LW, Rothstein JD, Bergles DE. Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nature Neuroscience. 16: 571-9. PMID 23542689 DOI: 10.1038/Nn.3357  0.42
2013 Morel L, Regan M, Higashimori H, Ng SK, Esau C, Vidensky S, Rothstein J, Yang Y. Neuronal exosomal miRNA-dependent translational regulation of astroglial glutamate transporter GLT1. The Journal of Biological Chemistry. 288: 7105-16. PMID 23364798 DOI: 10.1074/Jbc.M112.410944  0.351
2013 Donnelly CJ, Zhang PW, Pham JT, Haeusler AR, Mistry NA, Vidensky S, Daley EL, Poth EM, Hoover B, Fines DM, Maragakis N, Tienari PJ, Petrucelli L, Traynor BJ, Wang J, ... ... Rothstein JD, et al. RNA Toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention [Neuron, 79, (September 18, 2013), 1222-1231] Neuron. 80: 1102. DOI: 10.1016/J.Neuron.2013.10.055  0.591
2012 Teng YD, Benn SC, Kalkanis SN, Shefner JM, Onario RC, Cheng B, Lachyankar MB, Marconi M, Li J, Yu D, Han I, Maragakis NJ, Lládo J, Erkmen K, Redmond DE, ... ... Rothstein JD, et al. Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis. Science Translational Medicine. 4: 165ra164. PMID 23253611 DOI: 10.1126/Scitranslmed.3004579  0.639
2012 Lerman BJ, Hoffman EP, Sutherland ML, Bouri K, Hsu DK, Liu FT, Rothstein JD, Knoblach SM. Deletion of galectin-3 exacerbates microglial activation and accelerates disease progression and demise in a SOD1(G93A) mouse model of amyotrophic lateral sclerosis. Brain and Behavior. 2: 563-75. PMID 23139902 DOI: 10.1002/brb3.75  0.367
2012 Wray S, Self M, Lewis PA, Taanman JW, Ryan NS, Mahoney CJ, Liang Y, Devine MJ, Sheerin UM, Houlden H, Morris HR, Healy D, ... ... Rothstein JD, et al. Creation of an open-access, mutation-defined fibroblast resource for neurological disease research. Plos One. 7: e43099. PMID 22952635 DOI: 10.1371/Journal.Pone.0043099  0.585
2012 Lee Y, Morrison BM, Li Y, Lengacher S, Farah MH, Hoffman PN, Liu Y, Tsingalia A, Jin L, Zhang PW, Pellerin L, Magistretti PJ, Rothstein JD. Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature. 487: 443-8. PMID 22801498 DOI: 10.1038/Nature11314  0.347
2012 Phillips AW, Falahati S, DeSilva R, Shats I, Marx J, Arauz E, Kerr DA, Rothstein JD, Johnston MV, Fatemi A. Derivation of glial restricted precursors from E13 mice. Journal of Visualized Experiments : Jove. PMID 22760029 DOI: 10.3791/3462  0.516
2012 Brotherton TE, Li Y, Cooper D, Gearing M, Julien JP, Rothstein JD, Boylan K, Glass JD. Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS. Proceedings of the National Academy of Sciences of the United States of America. 109: 5505-10. PMID 22431618 DOI: 10.1073/Pnas.1115009109  0.419
2012 Benediktsson AM, Marrs GS, Tu JC, Worley PF, Rothstein JD, Bergles DE, Dailey ME. Neuronal activity regulates glutamate transporter dynamics in developing astrocytes. Glia. 60: 175-88. PMID 22052455 DOI: 10.1002/Glia.21249  0.39
2011 Gao Y, Perkins EM, Clarkson YL, Tobia S, Lyndon AR, Jackson M, Rothstein JD. β-III spectrin is critical for development of purkinje cell dendritic tree and spine morphogenesis. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 16581-90. PMID 22090485 DOI: 10.1523/JNEUROSCI.3332-11.2011  0.301
2011 Roux L, Benchenane K, Rothstein JD, Bonvento G, Giaume C. Plasticity of astroglial networks in olfactory glomeruli. Proceedings of the National Academy of Sciences of the United States of America. 108: 18442-6. PMID 21997206 DOI: 10.1073/pnas.1107386108  0.323
2011 Sattler R, Ayukawa Y, Coddington L, Sawa A, Block D, Chipkin R, Rothstein JD. Human nasal olfactory epithelium as a dynamic marker for CNS therapy development. Experimental Neurology. 232: 203-11. PMID 21945230 DOI: 10.1016/J.Expneurol.2011.09.002  0.342
2011 Renton AE, Majounie E, Waite A, Simón-Sánchez J, Rollinson S, Gibbs JR, Schymick JC, Laaksovirta H, van Swieten JC, Myllykangas L, Kalimo H, Paetau A, Abramzon Y, Remes AM, Kaganovich A, ... ... Rothstein JD, et al. A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron. 72: 257-68. PMID 21944779 DOI: 10.1016/J.Neuron.2011.09.010  0.316
2011 Ghosh M, Yang Y, Rothstein JD, Robinson MB. Nuclear factor-κB contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 31: 9159-69. PMID 21697367 DOI: 10.1523/Jneurosci.0302-11.2011  0.395
2011 Lepore AC, O'Donnell J, Bonner JF, Paul C, Miller ME, Rauck B, Kushner RA, Rothstein JD, Fischer I, Maragakis NJ. Spatial and temporal changes in promoter activity of the astrocyte glutamate transporter GLT1 following traumatic spinal cord injury. Journal of Neuroscience Research. 89: 1001-17. PMID 21488085 DOI: 10.1002/Jnr.22624  0.628
2011 Douville R, Liu J, Rothstein J, Nath A. Identification of active loci of a human endogenous retrovirus in neurons of patients with amyotrophic lateral sclerosis. Annals of Neurology. 69: 141-51. PMID 21280084 DOI: 10.1002/Ana.22149  0.386
2011 Maragakis N, Rothstein JD. New treatments in amyotrophic lateral sclerosis. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 36: 370-2. PMID 21116264 DOI: 10.1038/npp.2010.140  0.552
2011 Yang Y, Vidensky S, Jin L, Jie C, Lorenzini I, Frankl M, Rothstein JD. Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice. Glia. 59: 200-7. PMID 21046559 DOI: 10.1002/glia.21089  0.35
2011 Li Y, Sattler R, Yang EJ, Nunes A, Ayukawa Y, Akhtar S, Ji G, Zhang PW, Rothstein JD. Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression. Neuropharmacology. 60: 1168-75. PMID 21034752 DOI: 10.1016/J.Neuropharm.2010.10.016  0.416
2010 Johnson JO, Mandrioli J, Benatar M, Abramzon Y, Van Deerlin VM, Trojanowski JQ, Gibbs JR, Brunetti M, Gronka S, Wuu J, Ding J, McCluskey L, Martinez-Lage M, Falcone D, Hernandez DG, ... ... Rothstein J, et al. Exome sequencing reveals VCP mutations as a cause of familial ALS. Neuron. 68: 857-64. PMID 21145000 DOI: 10.1016/J.Neuron.2010.11.036  0.36
2010 Kang SH, Fukaya M, Yang JK, Rothstein JD, Bergles DE. NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron. 68: 668-81. PMID 21092857 DOI: 10.1016/J.Neuron.2010.09.009  0.356
2010 Paukert M, Huang YH, Tanaka K, Rothstein JD, Bergles DE. Zones of enhanced glutamate release from climbing fibers in the mammalian cerebellum. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 7290-9. PMID 20505095 DOI: 10.1523/Jneurosci.5118-09.2010  0.327
2010 Perkins EM, Clarkson YL, Sabatier N, Longhurst DM, Millward CP, Jack J, Toraiwa J, Watanabe M, Rothstein JD, Lyndon AR, Wyllie DJ, Dutia MB, Jackson M. Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 4857-67. PMID 20371805 DOI: 10.1523/JNEUROSCI.6065-09.2010  0.322
2010 de Vivo L, Melone M, Bucci G, Rothstein JD, Conti F. Quantitative analysis of EAAT4 promoter activity in neurons and astrocytes of mouse somatic sensory cortex. Neuroscience Letters. 474: 42-5. PMID 20211693 DOI: 10.1016/j.neulet.2010.03.003  0.35
2010 de Vivo L, Melone M, Rothstein JD, Conti F. GLT-1 Promoter Activity in Astrocytes and Neurons of Mouse Hippocampus and Somatic Sensory Cortex. Frontiers in Neuroanatomy. 3: 31. PMID 20161698 DOI: 10.3389/neuro.05.031.2009  0.328
2010 Yang Y, Gozen O, Vidensky S, Robinson MB, Rothstein JD. Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1. Glia. 58: 277-86. PMID 19672971 DOI: 10.1002/Glia.20922  0.411
2009 Klaus F, Gehring EM, Zürn A, Laufer J, Lindner R, Strutz-Seebohm N, Tavaré JM, Rothstein JD, Boehmer C, Palmada M, Gruner I, Lang UE, Seebohm G, Lang F. Regulation of the Na(+)-coupled glutamate transporter EAAT3 by PIKfyve. Neurochemistry International. 54: 372-7. PMID 19418632 DOI: 10.1016/J.Neuint.2009.01.002  0.356
2009 Carmen J, Rothstein JD, Kerr DA. Tumor necrosis factor-alpha modulates glutamate transport in the CNS and is a critical determinant of outcome from viral encephalomyelitis. Brain Research. 1263: 143-54. PMID 19368827 DOI: 10.1016/J.Brainres.2009.01.040  0.584
2009 Yang Y, Gozen O, Watkins A, Lorenzini I, Lepore A, Gao Y, Vidensky S, Brennan J, Poulsen D, Won Park J, Li Jeon N, Robinson MB, Rothstein JD. Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1. Neuron. 61: 880-94. PMID 19323997 DOI: 10.1016/J.Neuron.2009.02.010  0.428
2009 Chiò A, Schymick JC, Restagno G, Scholz SW, Lombardo F, Lai SL, Mora G, Fung HC, Britton A, Arepalli S, Gibbs JR, Nalls M, Berger S, Kwee LC, Oddone EZ, ... ... Rothstein J, et al. A two-stage genome-wide association study of sporadic amyotrophic lateral sclerosis. Human Molecular Genetics. 18: 1524-32. PMID 19193627 DOI: 10.1093/Hmg/Ddp059  0.305
2009 Rothstein JD. Current hypotheses for the underlying biology of amyotrophic lateral sclerosis. Annals of Neurology. 65: S3-9. PMID 19191304 DOI: 10.1002/ana.21543  0.427
2009 Maier S, Reiterer V, Ruggiero AM, Rothstein JD, Thomas S, Dahm R, Sitte HH, Farhan H. GTRAP3-18 serves as a negative regulator of Rab1 in protein transport and neuronal differentiation. Journal of Cellular and Molecular Medicine. 13: 114-24. PMID 18363836 DOI: 10.1111/J.1582-4934.2008.00303.X  0.751
2008 Lepore AC, Rauck B, Dejea C, Pardo AC, Rao MS, Rothstein JD, Maragakis NJ. Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nature Neuroscience. 11: 1294-301. PMID 18931666 DOI: 10.1038/Nn.2210  0.673
2008 Chang Y, Kong Q, Shan X, Tian G, Ilieva H, Cleveland DW, Rothstein JD, Borchelt DR, Wong PC, Lin CL. Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. Plos One. 3: e2849. PMID 18682740 DOI: 10.1371/Journal.Pone.0002849  0.38
2008 Tawfik VL, Regan MR, Haenggeli C, Lacroix-Fralish ML, Nutile-McMenemy N, Perez N, Rothstein JD, DeLeo JA. Propentofylline-induced astrocyte modulation leads to alterations in glial glutamate promoter activation following spinal nerve transection. Neuroscience. 152: 1086-92. PMID 18358622 DOI: 10.1016/j.neuroscience.2008.01.065  0.373
2008 Laird FM, Farah MH, Ackerley S, Hoke A, Maragakis N, Rothstein JD, Griffin J, Price DL, Martin LJ, Wong PC. Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1997-2005. PMID 18305234 DOI: 10.1523/Jneurosci.4231-07.2008  0.658
2008 Morrell CN, Sun H, Ikeda M, Beique JC, Swaim AM, Mason E, Martin TV, Thompson LE, Gozen O, Ampagoomian D, Sprengel R, Rothstein J, Faraday N, Huganir R, Lowenstein CJ. Glutamate mediates platelet activation through the AMPA receptor. The Journal of Experimental Medicine. 205: 575-84. PMID 18283118 DOI: 10.1084/Jem.20071474  0.314
2008 Ruggiero AM, Liu Y, Vidensky S, Maier S, Jung E, Farhan H, Robinson MB, Sitte HH, Rothstein JD. The endoplasmic reticulum exit of glutamate transporter is regulated by the inducible mammalian Yip6b/GTRAP3-18 protein. The Journal of Biological Chemistry. 283: 6175-83. PMID 18167356 DOI: 10.1074/Jbc.M701008200  0.73
2008 Liu Y, Vidensky S, Ruggiero AM, Maier S, Sitte HH, Rothstein JD. Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1. The Journal of Biological Chemistry. 283: 6561-71. PMID 18096700 DOI: 10.1074/Jbc.M708096200  0.754
2007 Rothstein JD. ALS--motor neuron disease: mechanism and development of new therapies. Journal of Visualized Experiments : Jove. 245. PMID 18997893 DOI: 10.3791/245  0.389
2007 Lepore AC, Haenggeli C, Gasmi M, Bishop KM, Bartus RT, Maragakis NJ, Rothstein JD. Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS. Brain Research. 1185: 256-65. PMID 17963733 DOI: 10.1016/J.Brainres.2007.09.034  0.622
2007 Regan MR, Huang YH, Kim YS, Dykes-Hoberg MI, Jin L, Watkins AM, Bergles DE, Rothstein JD. Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6607-19. PMID 17581948 DOI: 10.1523/Jneurosci.0790-07.2007  0.409
2007 Rumbaugh JA, Li G, Rothstein J, Nath A. Ceftriaxone protects against the neurotoxicity of human immunodeficiency virus proteins Journal of Neurovirology. 13: 168-172. PMID 17505985 DOI: 10.1080/13550280601178218  0.357
2007 Rothstein JD. TDP-43 in amyotrophic lateral sclerosis: pathophysiology or patho-babel? Annals of Neurology. 61: 382-4. PMID 17469124 DOI: 10.1002/ana.21155  0.304
2007 Schymick JC, Yang Y, Andersen PM, Vonsattel JP, Greenway M, Momeni P, Elder J, Chiò A, Restagno G, Robberecht W, Dahlberg C, Mukherjee O, Goate A, Graff-Radford N, Caselli RJ, ... ... Rothstein J, et al. Progranulin mutations and amyotrophic lateral sclerosis or amyotrophic lateral sclerosis-frontotemporal dementia phenotypes. Journal of Neurology, Neurosurgery, and Psychiatry. 78: 754-6. PMID 17371905 DOI: 10.1136/Jnnp.2006.109553  0.316
2007 Haenggeli C, Julien JP, Mosley RL, Perez N, Dhar A, Gendelman HE, Rothstein JD. Therapeutic immunization with a glatiramer acetate derivative does not alter survival in G93A and G37R SOD1 mouse models of familial ALS. Neurobiology of Disease. 26: 146-52. PMID 17276077 DOI: 10.1016/J.Nbd.2006.12.013  0.346
2007 Gincel D, Regan MR, Jin L, Watkins AM, Bergles DE, Rothstein JD. Analysis of cerebellar Purkinje cells using EAAT4 glutamate transporter promoter reporter in mice generated via bacterial artificial chromosome-mediated transgenesis. Experimental Neurology. 203: 205-12. PMID 17022974 DOI: 10.1016/j.expneurol.2006.08.016  0.399
2007 Maragakis NJ, Rothstein JD. Motor Neuron Disease: Amyotrophic Lateral Sclerosis Molecular Neurology. 307-319. DOI: 10.1016/B978-012369509-3.50022-6  0.598
2007 Maragakis NJ, Rothstein JD. Amyotrophic lateral sclerosis: Idiopathic and inherited Neurobiology of Disease. 521-535. DOI: 10.1016/B978-012088592-3/50048-7  0.647
2006 Maragakis NJ, Rothstein JD. Mechanisms of Disease: astrocytes in neurodegenerative disease. Nature Clinical Practice. Neurology. 2: 679-89. PMID 17117171 DOI: 10.1038/ncpneuro0355  0.604
2006 Lai C, Xie C, McCormack SG, Chiang HC, Michalak MK, Lin X, Chandran J, Shim H, Shimoji M, Cookson MR, Huganir RL, Rothstein JD, Price DL, Wong PC, Martin LJ, et al. Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 11798-806. PMID 17093100 DOI: 10.1523/Jneurosci.2084-06.2006  0.447
2006 Autry AE, Grillo CA, Piroli GG, Rothstein JD, McEwen BS, Reagan LP. Glucocorticoid regulation of GLT-1 glutamate transporter isoform expression in the rat hippocampus. Neuroendocrinology. 83: 371-9. PMID 17028421 DOI: 10.1159/000096092  0.317
2006 Deshpande DM, Kim YS, Martinez T, Carmen J, Dike S, Shats I, Rubin LL, Drummond J, Krishnan C, Hoke A, Maragakis N, Shefner J, Rothstein JD, Kerr DA. Recovery from paralysis in adult rats using embryonic stem cells. Annals of Neurology. 60: 32-44. PMID 16802299 DOI: 10.1002/Ana.20901  0.672
2006 Cudkowicz ME, Shefner JM, Schoenfeld DA, Zhang H, Andreasson KI, Rothstein JD, Drachman DB. Trial of celecoxib in amyotrophic lateral sclerosis. Annals of Neurology. 60: 22-31. PMID 16802291 DOI: 10.1002/Ana.20903  0.32
2006 Pardo AC, Wong V, Benson LM, Dykes M, Tanaka K, Rothstein JD, Maragakis NJ. Loss of the astrocyte glutamate transporter GLT1 modifies disease in SOD1(G93A) mice. Experimental Neurology. 201: 120-30. PMID 16753145 DOI: 10.1016/j.expneurol.2006.03.028  0.678
2006 Li LB, Toan SV, Zelenaia O, Watson DJ, Wolfe JH, Rothstein JD, Robinson MB. Regulation of astrocytic glutamate transporter expression by Akt: evidence for a selective transcriptional effect on the GLT-1/EAAT2 subtype. Journal of Neurochemistry. 97: 759-71. PMID 16573655 DOI: 10.1111/J.1471-4159.2006.03743.X  0.35
2006 Longhurst DM, Watanabe M, Rothstein JD, Jackson M. Interaction of PDZRhoGEF with microtubule-associated protein 1 light chains: link between microtubules, actin cytoskeleton, and neuronal polarity. The Journal of Biological Chemistry. 281: 12030-40. PMID 16478718 DOI: 10.1074/jbc.M513756200  0.305
2006 Ikeda Y, Dick KA, Weatherspoon MR, Gincel D, Armbrust KR, Dalton JC, Stevanin G, Dürr A, Zühlke C, Bürk K, Clark HB, Brice A, Rothstein JD, Schut LJ, Day JW, et al. Spectrin mutations cause spinocerebellar ataxia type 5. Nature Genetics. 38: 184-90. PMID 16429157 DOI: 10.1038/Ng1728  0.308
2006 Ganel R, Ho T, Maragakis NJ, Jackson M, Steiner JP, Rothstein JD. Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection. Neurobiology of Disease. 21: 556-67. PMID 16274998 DOI: 10.1016/j.nbd.2005.08.014  0.677
2006 Lladó J, Haenggeli C, Pardo A, Wong V, Benson L, Coccia C, Rothstein JD, Shefner JM, Maragakis NJ. Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS. Neurobiology of Disease. 21: 110-8. PMID 16084734 DOI: 10.1016/j.nbd.2005.06.019  0.637
2006 Haenggeli C, Lepore AC, Perez N, Kaspar BK, Rothstein JD. 245. Delivery of IGF-1 in the Spinal Cord of a Mouse Model of ALS after Intraparenchymal Injection of an Adeno-Associated Vector Molecular Therapy. 13: S94. DOI: 10.1016/J.Ymthe.2006.08.272  0.305
2005 Furuta A, Takashima S, Yokoo H, Rothstein JD, Wada K, Iwaki T. Expression of glutamate transporter subtypes during normal human corticogenesis and type II lissencephaly. Brain Research. Developmental Brain Research. 155: 155-64. PMID 15804404 DOI: 10.1016/j.devbrainres.2005.01.005  0.396
2005 Maragakis NJ, Rao MS, Llado J, Wong V, Xue H, Pardo A, Herring J, Kerr D, Coccia C, Rothstein JD. Glial restricted precursors protect against chronic glutamate neurotoxicity of motor neurons in vitro. Glia. 50: 145-59. PMID 15657939 DOI: 10.1002/glia.20161  0.726
2005 Rothstein JD, Patel S, Regan MR, Haenggeli C, Huang YH, Bergles DE, Jin L, Dykes Hoberg M, Vidensky S, Chung DS, Toan SV, Bruijn LI, Su ZZ, Gupta P, Fisher PB. Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature. 433: 73-7. PMID 15635412 DOI: 10.1038/Nature03180  0.432
2005 Haenggeli C, Rothstein JD, Kaspar BK. 653. Injection of AAV Directly into the Spinal Cord Increases Levels of Gene Expression Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.193  0.389
2005 Haenggeli C, Kaspar B, Rothstein J. 652. Adeno-Associated Vector Delivery of Gutamate Transporters in an ALS Mouse Model Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.192  0.505
2005 Kaspar BK, Christian L, Frost L, Rothstein JD, Gage FH. 650. AAV-IGF1 and Exercise for Synergistic Therapies in ALS Molecular Therapy. 11. DOI: 10.1016/J.Ymthe.2005.07.190  0.412
2004 Shefner JM, Cudkowicz ME, Schoenfeld D, Conrad T, Taft J, Chilton M, Urbinelli L, Qureshi M, Zhang H, Pestronk A, Caress J, Donofrio P, Sorenson E, Bradley W, Lomen-Hoerth C, ... ... Rothstein J, et al. A clinical trial of creatine in ALS. Neurology. 63: 1656-61. PMID 15534251 DOI: 10.1212/01.Wnl.0000142992.81995.F0  0.328
2004 Lladó J, Haenggeli C, Maragakis NJ, Snyder EY, Rothstein JD. Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors. Molecular and Cellular Neurosciences. 27: 322-31. PMID 15519246 DOI: 10.1016/j.mcn.2004.07.010  0.637
2004 Darman J, Backovic S, Dike S, Maragakis NJ, Krishnan C, Rothstein JD, Irani DN, Kerr DA. Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 7566-75. PMID 15329404 DOI: 10.1523/JNEUROSCI.2002-04.2004  0.717
2004 Harper JM, Krishnan C, Darman JS, Deshpande DM, Peck S, Shats I, Backovic S, Rothstein JD, Kerr DA. Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats. Proceedings of the National Academy of Sciences of the United States of America. 101: 7123-8. PMID 15118094 DOI: 10.1073/pnas.0401103101  0.498
2004 Schniepp R, Kohler K, Ladewig T, Guenther E, Henke G, Palmada M, Boehmer C, Rothstein JD, Bröer S, Lang F. Retinal colocalization and in vitro interaction of the glutamate transporter EAAT3 and the serum- and glucocorticoid-inducible kinase SGK1 [correction]. Investigative Ophthalmology & Visual Science. 45: 1442-9. PMID 15111600 DOI: 10.1167/Iovs.03-0062  0.381
2004 Maragakis NJ, Rothstein JD. Glutamate transporters: animal models to neurologic disease. Neurobiology of Disease. 15: 461-73. PMID 15056453 DOI: 10.1016/j.nbd.2003.12.007  0.643
2004 Nargi-Aizenman JL, Havert MB, Zhang M, Irani DN, Rothstein JD, Griffin DE. Glutamate receptor antagonists protect from virus-induced neural degeneration. Annals of Neurology. 55: 541-9. PMID 15048893 DOI: 10.1002/Ana.20033  0.377
2004 Maragakis NJ, Dykes-Hoberg M, Rothstein JD. Altered expression of the glutamate transporter EAAT2b in neurological disease. Annals of Neurology. 55: 469-77. PMID 15048885 DOI: 10.1002/ana.20003  0.671
2004 Reagan LP, Rosell DR, Wood GE, Spedding M, Muñoz C, Rothstein J, McEwen BS. Chronic restraint stress up-regulates GLT-1 mRNA and protein expression in the rat hippocampus: reversal by tianeptine. Proceedings of the National Academy of Sciences of the United States of America. 101: 2179-84. PMID 14766991 DOI: 10.1073/pnas.0307294101  0.33
2004 Tao F, Liaw WJ, Zhang B, Yaster M, Rothstein JD, Johns RA, Tao YX. Evidence of neuronal excitatory amino acid carrier 1 expression in rat dorsal root ganglion neurons and their central terminals. Neuroscience. 123: 1045-51. PMID 14751295 DOI: 10.1016/j.neuroscience.2003.11.026  0.398
2004 Maragakis NJ, Dietrich J, Wong V, Xue H, Mayer-Proschel M, Rao MS, Rothstein JD. Glutamate transporter expression and function in human glial progenitors. Glia. 45: 133-43. PMID 14730707 DOI: 10.1002/Glia.10310  0.656
2004 Huang YH, Dykes-Hoberg M, Tanaka K, Rothstein JD, Bergles DE. Climbing fiber activation of EAAT4 transporters and kainate receptors in cerebellar Purkinje cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 103-11. PMID 14715943 DOI: 10.1523/Jneurosci.4473-03.2004  0.343
2003 Boehmer C, Henke G, Schniepp R, Palmada M, Rothstein JD, Bröer S, Lang F. Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B. Journal of Neurochemistry. 86: 1181-8. PMID 12911626 DOI: 10.1046/J.1471-4159.2003.01937.X  0.351
2003 Kaspar BK, Lladó J, Sherkat N, Rothstein JD, Gage FH. Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science (New York, N.Y.). 301: 839-42. PMID 12907804 DOI: 10.1126/Science.1086137  0.415
2003 Wang Z, Pekarskaya O, Bencheikh M, Chao W, Gelbard HA, Ghorpade A, Rothstein JD, Volsky DJ. Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. Virology. 312: 60-73. PMID 12890621 DOI: 10.1016/S0042-6822(03)00181-8  0.375
2003 Furuta A, Noda M, Suzuki SO, Goto Y, Kanahori Y, Rothstein JD, Iwaki T. Translocation of glutamate transporter subtype excitatory amino acid carrier 1 protein in kainic acid-induced rat epilepsy. The American Journal of Pathology. 163: 779-87. PMID 12875997 DOI: 10.1016/S0002-9440(10)63705-4  0.398
2003 Kerr DA, Lladó J, Shamblott MJ, Maragakis NJ, Irani DN, Crawford TO, Krishnan C, Dike S, Gearhart JD, Rothstein JD. Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5131-40. PMID 12832537 DOI: 10.1523/Jneurosci.23-12-05131.2003  0.698
2003 Thomas AG, Corse AM, Coccia CF, Bilak MM, Rothstein JD, Slusher BS. NAALADase inhibition protects motor neurons against chronic glutamate toxicity. European Journal of Pharmacology. 471: 177-84. PMID 12826236 DOI: 10.1016/S0014-2999(03)01832-6  0.438
2003 Maragakis NJ, Jackson M, Ganel R, Rothstein JD. Topiramate protects against motor neuron degeneration in organotypic spinal cord cultures but not in G93A SOD1 transgenic mice. Neuroscience Letters. 338: 107-10. PMID 12566164 DOI: 10.1016/S0304-3940(02)01386-1  0.678
2003 Niederberger E, Schmidtko A, Rothstein JD, Geisslinger G, Tegeder I. Modulation of spinal nociceptive processing through the glutamate transporter GLT-1. Neuroscience. 116: 81-7. PMID 12535941 DOI: 10.1016/S0306-4522(02)00547-X  0.401
2002 Jackson M, Ganel R, Rothstein JD. Models of amyotrophic lateral sclerosis. Current Protocols in Neuroscience / Editorial Board, Jacqueline N. Crawley ... [Et Al.]. Unit 9.13. PMID 18428572 DOI: 10.1002/0471142301.ns0913s20  0.419
2002 Drachman DB, Frank K, Dykes-Hoberg M, Teismann P, Almer G, Przedborski S, Rothstein JD. Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS. Annals of Neurology. 52: 771-8. PMID 12447931 DOI: 10.1002/Ana.10374  0.419
2002 Jackson M, Lladó J, Rothstein JD. Therapeutic developments in the treatment of amyotrophic lateral sclerosis. Expert Opinion On Investigational Drugs. 11: 1343-64. PMID 12387699 DOI: 10.1517/13543784.11.10.1343  0.43
2002 Cutler RG, Pedersen WA, Camandola S, Rothstein JD, Mattson MP. Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis. Annals of Neurology. 52: 448-57. PMID 12325074 DOI: 10.1002/Ana.10312  0.395
2002 Sepkuty JP, Cohen AS, Eccles C, Rafiq A, Behar K, Ganel R, Coulter DA, Rothstein JD. A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 6372-9. PMID 12151515 DOI: 10.1523/Jneurosci.22-15-06372.2002  0.335
2002 Subramaniam JR, Lyons WE, Liu J, Bartnikas TB, Rothstein J, Price DL, Cleveland DW, Gitlin JD, Wong PC. Mutant SOD1 causes motor neuron disease independent of copper chaperone-mediated copper loading. Nature Neuroscience. 5: 301-7. PMID 11889469 DOI: 10.1038/Nn823  0.359
2002 Howland DS, Liu J, She Y, Goad B, Maragakis NJ, Kim B, Erickson J, Kulik J, DeVito L, Psaltis G, DeGennaro LJ, Cleveland DW, Rothstein JD. Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proceedings of the National Academy of Sciences of the United States of America. 99: 1604-9. PMID 11818550 DOI: 10.1073/pnas.032539299  0.667
2001 Watanabe M, Dykes-Hoberg M, Culotta VC, Price DL, Wong PC, Rothstein JD. Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues. Neurobiology of Disease. 8: 933-41. PMID 11741389 DOI: 10.1006/nbdi.2001.0443  0.388
2001 Cleveland DW, Rothstein JD. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nature Reviews. Neuroscience. 2: 806-19. PMID 11715057 DOI: 10.1038/35097565  0.421
2001 Rothstein JD, Brem H. Excitotoxic destruction facilitates brain tumor growth. Nature Medicine. 7: 994-5. PMID 11533696 DOI: 10.1038/Nm0901-994  0.308
2001 Melone M, Vitellaro-Zuccarello L, Vallejo-Illarramendi A, Pérez-Samartin A, Matute C, Cozzi A, Pellegrini-Giampietro DE, Rothstein JD, Conti F. The expression of glutamate transporter GLT-1 in the rat cerebral cortex is down-regulated by the antipsychotic drug clozapine. Molecular Psychiatry. 6: 380-6. PMID 11443521 DOI: 10.1038/  0.356
2001 Maragakis NJ, Rothstein JD. Glutamate transporters in neurologic disease. Archives of Neurology. 58: 365-70. PMID 11255439 DOI: 10.1001/Archneur.58.3.365  0.615
2001 Rao VL, Dogan A, Todd KG, Bowen KK, Kim BT, Rothstein JD, Dempsey RJ. Antisense knockdown of the glial glutamate transporter GLT-1, but not the neuronal glutamate transporter EAAC1, exacerbates transient focal cerebral ischemia-induced neuronal damage in rat brain. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1876-83. PMID 11245672 DOI: 10.1523/Jneurosci.21-06-01876.2001  0.409
2001 Jackson M, Song W, Liu MY, Jin L, Dykes-Hoberg M, Lin CI, Bowers WJ, Federoff HJ, Sternweis PC, Rothstein JD. Modulation of the neuronal glutamate transporter EAAT4 by two interacting proteins. Nature. 410: 89-93. PMID 11242047 DOI: 10.1038/35065091  0.404
2001 Lin CI, Orlov I, Ruggiero AM, Dykes-Hoberg M, Lee A, Jackson M, Rothstein JD. Modulation of the neuronal glutamate transporter EAAC1 by the interacting protein GTRAP3-18. Nature. 410: 84-8. PMID 11242046 DOI: 10.1038/35065084  0.75
2001 Podkletnova I, Rothstein JD, Helén P, Alho H. Microglial response to the neurotoxicity of 6-hydroxydopamine in neonatal rat cerebellum. International Journal of Developmental Neuroscience : the Official Journal of the International Society For Developmental Neuroscience. 19: 47-52. PMID 11226754 DOI: 10.1016/S0736-5748(00)00069-1  0.302
2001 Erkmen K, Teng YD, Sidman RL, Sheffner J, Snyder BD, Girolami UD, Ensrud E, Kosaras B, Kalkanis S, Brown RH, Rothstein J, Redmond DE, Snyder EY. 750 Transplantation of Human Neural Stem Cells in a New Primate Model of Motor Neuron Degeneration: An Experimental Study of Potential Cell Therapy for Amyotrophic Lateral Sclerosis Neurosurgery. 49: 521-521. DOI: 10.1097/00006123-200108000-00114  0.362
2000 Drachman DB, Rothstein JD. Inhibition of cyclooxygenase-2 protects motor neurons in an organotypic model of amyotrophic lateral sclerosis. Annals of Neurology. 48: 792-5. PMID 11079544 DOI: 10.1002/1531-8249(200011)48:5<792::AID-ANA14>3.0.CO;2-5  0.45
2000 Rothstein JD. Neurobiology. Bundling up excitement. Nature. 407: 141, 143. PMID 11001037 DOI: 10.1038/35025170  0.331
2000 Vos CM, Sjulson L, Nath A, McArthur JC, Pardo CA, Rothstein J, Conant K. Cytotoxicity by matrix metalloprotease-1 in organotypic spinal cord and dissociated neuronal cultures. Experimental Neurology. 163: 324-30. PMID 10833306 DOI: 10.1006/Exnr.2000.7388  0.337
2000 Raghavendra Rao VL, Rao AM, Dogan A, Bowen KK, Hatcher J, Rothstein JD, Dempsey RJ. Glial glutamate transporter GLT-1 down-regulation precedes delayed neuronal death in gerbil hippocampus following transient global cerebral ischemia. Neurochemistry International. 36: 531-7. PMID 10762090 DOI: 10.1016/S0197-0186(99)00153-9  0.385
2000 Zelenaia O, Schlag BD, Gochenauer GE, Ganel R, Song W, Beesley JS, Grinspan JB, Rothstein JD, Robinson MB. Epidermal growth factor receptor agonists increase expression of glutamate transporter GLT-1 in astrocytes through pathways dependent on phosphatidylinositol 3-kinase and transcription factor NF-kappaB. Molecular Pharmacology. 57: 667-78. PMID 10727511 DOI: 10.1124/Mol.57.4.667  0.384
2000 He Y, Janssen WG, Rothstein JD, Morrison JH. Differential synaptic localization of the glutamate transporter EAAC1 and glutamate receptor subunit GluR2 in the rat hippocampus. The Journal of Comparative Neurology. 418: 255-69. PMID 10701825 DOI: 10.1002/(SICI)1096-9861(20000313)418:3<255::AID-CNE2>3.0.CO;2-6  0.355
2000 Ho TW, Bristol LA, Coccia C, Li Y, Milbrandt J, Johnson E, Jin L, Bar-Peled O, Griffin JW, Rothstein JD. TGFbeta trophic factors differentially modulate motor axon outgrowth and protection from excitotoxicity. Experimental Neurology. 161: 664-75. PMID 10686085 DOI: 10.1006/Exnr.1999.7290  0.331
1999 Ye ZC, Rothstein JD, Sontheimer H. Compromised glutamate transport in human glioma cells: reduction-mislocalization of sodium-dependent glutamate transporters and enhanced activity of cystine-glutamate exchange. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 10767-77. PMID 10594060 DOI: 10.1523/Jneurosci.19-24-10767.1999  0.395
1999 Corse AM, Bilak MM, Bilak SR, Lehar M, Rothstein JD, Kuncl RW. Preclinical testing of neuroprotective neurotrophic factors in a model of chronic motor neuron degeneration. Neurobiology of Disease. 6: 335-46. PMID 10527802 DOI: 10.1006/nbdi.1999.0253  0.445
1999 Bar-Peled O, O'Brien RJ, Morrison JH, Rothstein JD. Cultured motor neurons possess calcium-permeable AMPA/kainate receptors. Neuroreport. 10: 855-9. PMID 10208560 DOI: 10.1097/00001756-199903170-00034  0.407
1999 Bar-Peled O, Knudson M, Korsmeyer SJ, Rothstein JD. Motor neuron degeneration is attenuated in bax-deficient neurons in vitro. Journal of Neuroscience Research. 55: 542-56. PMID 10082077 DOI: 10.1002/(SICI)1097-4547(19990301)55:5<542::AID-JNR2>3.0.CO;2-7  0.395
1999 Simantov R, Crispino M, Hoe W, Broutman G, Tocco G, Rothstein JD, Baudry M. Changes in expression of neuronal and glial glutamate transporters in rat hippocampus following kainate-induced seizure activity. Brain Research. Molecular Brain Research. 65: 112-23. PMID 10036313 DOI: 10.1016/S0169-328X(98)00349-0  0.405
1999 Rothstein JD, Dykes-Hoberg M, Corson LB, Becker M, Cleveland DW, Price DL, Culotta VC, Wong PC. The copper chaperone CCS is abundant in neurons and astrocytes in human and rodent brain. Journal of Neurochemistry. 72: 422-9. PMID 9886096 DOI: 10.1046/j.1471-4159.1999.0720422.x  0.411
1998 Wong PC, Rothstein JD, Price DL. The genetic and molecular mechanisms of motor neuron disease. Current Opinion in Neurobiology. 8: 791-9. PMID 9914243 DOI: 10.1016/S0959-4388(98)80123-2  0.367
1998 Meaney JA, Balcar VJ, Rothstein JD, Jeffrey PL. Glutamate transport in cultures from developing avian cerebellum: presence of GLT-1 immunoreactivity in Purkinje neurons. Journal of Neuroscience Research. 54: 595-603. PMID 9843150 DOI: 10.1002/(Sici)1097-4547(19981201)54:5<595::Aid-Jnr4>3.0.Co;2-Q  0.316
1998 Lin CL, Tzingounis AV, Jin L, Furuta A, Kavanaugh MP, Rothstein JD. Molecular cloning and expression of the rat EAAT4 glutamate transporter subtype. Brain Research. Molecular Brain Research. 63: 174-9. PMID 9838098 DOI: 10.1016/S0169-328X(98)00256-3  0.38
1998 Bristol LA, Rothstein JD. Use of antisense oligodeoxynucleotides to inhibit expression of glutamate transporter subtypes. Methods in Enzymology. 296: 514-29. PMID 9779471 DOI: 10.1016/S0076-6879(98)96037-2  0.334
1998 Northington FJ, Traystman RJ, Koehler RC, Rothstein JD, Martin LJ. Regional and cellular expression of glial (GLT1) and neuronal (EAAC1) glutamate transporter proteins in ovine fetal brain. Neuroscience. 85: 1183-94. PMID 9681956 DOI: 10.1016/S0306-4522(97)00673-8  0.435
1998 Mennerick S, Dhond RP, Benz A, Xu W, Rothstein JD, Danbolt NC, Isenberg KE, Zorumski CF. Neuronal expression of the glutamate transporter GLT-1 in hippocampal microcultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 4490-9. PMID 9614226 DOI: 10.1523/Jneurosci.18-12-04490.1998  0.437
1998 Cooper B, Chebib M, Shen J, King NJ, Darvey IG, Kuchel PW, Rothstein JD, Balcar VJ. Structural selectivity and molecular nature of L-glutamate transport in cultured human fibroblasts. Archives of Biochemistry and Biophysics. 353: 356-64. PMID 9606970 DOI: 10.1006/Abbi.1998.0626  0.371
1998 Aoki M, Lin CL, Rothstein JD, Geller BA, Hosler BA, Munsat TL, Horvitz HR, Brown RH. Mutations in the glutamate transporter EAAT2 gene do not cause abnormal EAAT2 transcripts in amyotrophic lateral sclerosis. Annals of Neurology. 43: 645-53. PMID 9585360 DOI: 10.1002/Ana.410430514  0.331
1998 Rao VL, BaÅŸkaya MK, DoÄŸan A, Rothstein JD, Dempsey RJ. Traumatic brain injury down-regulates glial glutamate transporter (GLT-1 and GLAST) proteins in rat brain. Journal of Neurochemistry. 70: 2020-7. PMID 9572288 DOI: 10.1046/J.1471-4159.1998.70052020.X  0.379
1998 Conti F, DeBiasi S, Minelli A, Rothstein JD, Melone M. EAAC1, a high-affinity glutamate tranporter, is localized to astrocytes and gabaergic neurons besides pyramidal cells in the rat cerebral cortex. Cerebral Cortex (New York, N.Y. : 1991). 8: 108-16. PMID 9542890 DOI: 10.1093/cercor/8.2.108  0.399
1998 Lin CL, Bristol LA, Jin L, Dykes-Hoberg M, Crawford T, Clawson L, Rothstein JD. Aberrant RNA processing in a neurodegenerative disease: the cause for absent EAAT2, a glutamate transporter, in amyotrophic lateral sclerosis. Neuron. 20: 589-602. PMID 9539131 DOI: 10.1016/S0896-6273(00)80997-6  0.445
1998 Matthews JC, Beveridge MJ, Malandro MS, Rothstein JD, Campbell-Thompson M, Verlander JW, Kilberg MS, Novak DA. Activity and protein localization of multiple glutamate transporters in gestation day 14 vs. day 20 rat placenta. The American Journal of Physiology. 274: C603-14. PMID 9530091 DOI: 10.1152/Ajpcell.1998.274.3.C603  0.332
1998 Davis KE, Straff DJ, Weinstein EA, Bannerman PG, Correale DM, Rothstein JD, Robinson MB. Multiple signaling pathways regulate cell surface expression and activity of the excitatory amino acid carrier 1 subtype of Glu transporter in C6 glioma. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 18: 2475-85. PMID 9502808 DOI: 10.1523/Jneurosci.18-07-02475.1998  0.397
1998 Schlag BD, Vondrasek JR, Munir M, Kalandadze A, Zelenaia OA, Rothstein JD, Robinson MB. Regulation of the glial Na+-dependent glutamate transporters by cyclic AMP analogs and neurons. Molecular Pharmacology. 53: 355-69. PMID 9495799 DOI: 10.1124/Mol.53.3.355  0.309
1997 Shayakul C, Kanai Y, Lee WS, Brown D, Rothstein JD, Hediger MA. Localization of the high-affinity glutamate transporter EAAC1 in rat kidney. The American Journal of Physiology. 273: F1023-9. PMID 9435692 DOI: 10.1152/Ajprenal.1997.273.6.F1023  0.318
1997 Coco S, Verderio C, Trotti D, Rothstein JD, Volterra A, Matteoli M. Non-synaptic localization of the glutamate transporter EAAC1 in cultured hippocampal neurons. The European Journal of Neuroscience. 9: 1902-10. PMID 9383213 DOI: 10.1111/J.1460-9568.1997.Tb00757.X  0.379
1997 Bar-Peled O, Ben-Hur H, Biegon A, Groner Y, Dewhurst S, Furuta A, Rothstein JD. Distribution of glutamate transporter subtypes during human brain development. Journal of Neurochemistry. 69: 2571-80. PMID 9375691 DOI: 10.1046/J.1471-4159.1997.69062571.X  0.387
1997 Furuta A, Rothstein JD, Martin LJ. Glutamate transporter protein subtypes are expressed differentially during rat CNS development. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 8363-75. PMID 9334410 DOI: 10.1523/Jneurosci.17-21-08363.1997  0.427
1997 Furuta A, Martin LJ, Lin CL, Dykes-Hoberg M, Rothstein JD. Cellular and synaptic localization of the neuronal glutamate transporters excitatory amino acid transporter 3 and 4. Neuroscience. 81: 1031-42. PMID 9330365 DOI: 10.1016/S0306-4522(97)00252-2  0.429
1997 Martin LJ, Brambrink AM, Lehmann C, Portera-Cailliau C, Koehler R, Rothstein J, Traystman RJ. Hypoxia-ischemia causes abnormalities in glutamate transporters and death of astroglia and neurons in newborn striatum. Annals of Neurology. 42: 335-48. PMID 9307255 DOI: 10.1002/Ana.410420310  0.417
1997 O'Brien RJ, Mammen AL, Blackshaw S, Ehlers MD, Rothstein JD, Huganir RL. The development of excitatory synapses in cultured spinal neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 7339-50. PMID 9295380 DOI: 10.1523/Jneurosci.17-19-07339.1997  0.333
1997 Keller JN, Mark RJ, Bruce AJ, Blanc E, Rothstein JD, Uchida K, Waeg G, Mattson MP. 4-Hydroxynonenal, an aldehydic product of membrane lipid peroxidation, impairs glutamate transport and mitochondrial function in synaptosomes. Neuroscience. 80: 685-96. PMID 9276486 DOI: 10.1016/S0306-4522(97)00065-1  0.377
1997 Liu MT, Rothstein JD, Gershon MD, Kirchgessner AL. Glutamatergic enteric neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 4764-84. PMID 9169536 DOI: 10.1523/Jneurosci.17-12-04764.1997  0.4
1997 Miller HP, Levey AI, Rothstein JD, Tzingounis AV, Conn PJ. Alterations in glutamate transporter protein levels in kindling-induced epilepsy. Journal of Neurochemistry. 68: 1564-70. PMID 9084427 DOI: 10.1046/J.1471-4159.1997.68041564.X  0.321
1997 Bruijn LI, Becher MW, Lee MK, Anderson KL, Jenkins NA, Copeland NG, Sisodia SS, Rothstein JD, Borchelt DR, Price DL, Cleveland DW. ALS-linked SOD1 mutant G85R mediates damage to astrocytes and promotes rapidly progressive disease with SOD1-containing inclusions. Neuron. 18: 327-38. PMID 9052802 DOI: 10.1016/S0896-6273(00)80272-X  0.459
1997 Swanson RA, Liu J, Miller JW, Rothstein JD, Farrell K, Stein BA, Longuemare MC. Neuronal regulation of glutamate transporter subtype expression in astrocytes. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 17: 932-40. PMID 8994048 DOI: 10.1523/Jneurosci.17-03-00932.1997  0.405
1997 Aoki M, Rothstein JD, Lin CG, Geller BA, Hosler BA, Munsat TL, Horvitz HR, Brown RH. Mutations of the glutamate transporter gene EAAT2 do not cause the abnormal EAAT2 transcripts in patients with amyotrophic lateral sclerosis Neuromuscular Disorders. 7: 475. DOI: 10.1016/S0960-8966(97)87358-0  0.357
1997 Bar-Peled O, Vornov J, O'Brien R, Morrison J, Knudson C, Korsmeyer S, Rothstein J. Enhanced susceptibility of motor neurons to excitotoxicity is dependent on Ca2+-permeable AMPA/kainate receptors and BAX expression Neuroscience Letters. 237: S7. DOI: 10.1016/S0304-3940(97)90027-6  0.364
1996 Rothstein JD. Therapeutic horizons for amyotrophic lateral sclerosis. Current Opinion in Neurobiology. 6: 679-87. PMID 8937834 DOI: 10.1016/S0959-4388(96)80103-6  0.379
1996 Medina L, Figueredo-Cardenas G, Rothstein JD, Reiner A. Differential abundance of glutamate transporter subtypes in amyotrophic lateral sclerosis (ALS)-vulnerable versus ALS-resistant brain stem motor cell groups. Experimental Neurology. 142: 287-95. PMID 8934560 DOI: 10.1006/exnr.1996.0198  0.425
1996 Rauen T, Rothstein JD, Wässle H. Differential expression of three glutamate transporter subtypes in the rat retina. Cell and Tissue Research. 286: 325-36. PMID 8929335 DOI: 10.1007/s004410050702  0.382
1996 Rothstein JD, Dykes-Hoberg M, Pardo CA, Bristol LA, Jin L, Kuncl RW, Kanai Y, Hediger MA, Wang Y, Schielke JP, Welty DF. Knockout of glutamate transporters reveals a major role for astroglial transport in excitotoxicity and clearance of glutamate. Neuron. 16: 675-86. PMID 8785064 DOI: 10.1016/S0896-6273(00)80086-0  0.4
1996 Ginsberg SD, Rothstein JD, Price DL, Martin LJ. Fimbria-fornix transections selectively down-regulate subtypes of glutamate transporter and glutamate receptor proteins in septum and hippocampus. Journal of Neurochemistry. 67: 1208-16. PMID 8752128 DOI: 10.1046/J.1471-4159.1996.67031208.X  0.373
1996 Fine SM, Angel RA, Perry SW, Epstein LG, Rothstein JD, Dewhurst S, Gelbard HA. Tumor necrosis factor alpha inhibits glutamate uptake by primary human astrocytes. Implications for pathogenesis of HIV-1 dementia. The Journal of Biological Chemistry. 271: 15303-6. PMID 8663435 DOI: 10.1074/Jbc.271.26.15303  0.329
1996 Bristol LA, Rothstein JD. Glutamate transporter gene expression in amyotrophic lateral sclerosis motor cortex. Annals of Neurology. 39: 676-9. PMID 8619555 DOI: 10.1002/ana.410390519  0.436
1995 Welty DF, Schielke GP, Rothstein JD. Potential treatment of amyotrophic lateral sclerosis with gabapentin: a hypothesis. The Annals of Pharmacotherapy. 29: 1164-7. PMID 8573965 DOI: 10.1177/106002809502901118  0.436
1995 Rothstein JD, Kuncl RW. Neuroprotective strategies in a model of chronic glutamate-mediated motor neuron toxicity. Journal of Neurochemistry. 65: 643-51. PMID 7616220 DOI: 10.1046/J.1471-4159.1995.65020643.X  0.436
1995 Rothstein JD, Van Kammen M, Levey AI, Martin LJ, Kuncl RW. Selective loss of glial glutamate transporter GLT-1 in amyotrophic lateral sclerosis. Annals of Neurology. 38: 73-84. PMID 7611729 DOI: 10.1002/Ana.410380114  0.461
1995 Ginsberg SD, Martin LJ, Rothstein JD. Regional deafferentation down-regulates subtypes of glutamate transporter proteins. Journal of Neurochemistry. 65: 2800-3. PMID 7595581 DOI: 10.1046/J.1471-4159.1995.65062800.X  0.388
1994 Rothstein JD, Martin L, Levey AI, Dykes-Hoberg M, Jin L, Wu D, Nash N, Kuncl RW. Localization of neuronal and glial glutamate transporters. Neuron. 13: 713-25. PMID 7917301 DOI: 10.1016/0896-6273(94)90038-8  0.43
1994 Rothstein JD, Bristol LA, Hosler B, Brown RH, Kuncl RW. Chronic inhibition of superoxide dismutase produces apoptotic death of spinal neurons. Proceedings of the National Academy of Sciences of the United States of America. 91: 4155-9. PMID 7910402 DOI: 10.1073/Pnas.91.10.4155  0.444
1993 Rothstein JD, Jin L, Dykes-Hoberg M, Kuncl RW. Chronic inhibition of glutamate uptake produces a model of slow neurotoxicity. Proceedings of the National Academy of Sciences of the United States of America. 90: 6591-5. PMID 8393571 DOI: 10.1073/Pnas.90.14.6591  0.425
1992 Rothstein JD, Martin LJ, Kuncl RW. Decreased glutamate transport by the brain and spinal cord in amyotrophic lateral sclerosis. The New England Journal of Medicine. 326: 1464-8. PMID 1349424 DOI: 10.1056/Nejm199205283262204  0.447
1992 Rothstein JD, Guidotti A, Costa E. Release of endogenous benzodiazepine receptor ligands (endozepines) from cultured neurons. Neuroscience Letters. 143: 210-4. PMID 1331901 DOI: 10.1016/0304-3940(92)90267-B  0.302
1991 Tsai GC, Stauch-Slusher B, Sim L, Hedreen JC, Rothstein JD, Kuncl R, Coyle JT. Reductions in acidic amino acids and N-acetylaspartylglutamate in amyotrophic lateral sclerosis CNS. Brain Research. 556: 151-6. PMID 1682006 DOI: 10.1016/0006-8993(91)90560-I  0.374
1990 Rothstein JD, Tsai G, Kuncl RW, Clawson L, Cornblath DR, Drachman DB, Pestronk A, Stauch BL, Coyle JT. Abnormal excitatory amino acid metabolism in amyotrophic lateral sclerosis. Annals of Neurology. 28: 18-25. PMID 2375630 DOI: 10.1002/ana.410280106  0.408
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