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Nicholas H. Varvel, PhD - Publications

Affiliations: 
2013- Pharmacology Emory University, Atlanta, GA 
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24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Alemán-Ruiz C, Wang W, Dingledine R, Varvel NH. Pharmacological inhibition of the inflammatory receptor CCR2 relieves the early deleterious consequences of status epilepticus. Scientific Reports. 13: 5651. PMID 37024553 DOI: 10.1038/s41598-023-32752-9  0.598
2022 Varvel NH, Amaradhi R, Espinosa-Garcia C, Duddy S, Franklin R, Banik A, Alemán-Ruiz C, Blackmar-Raynolds L, Wang W, Honore T, Ganesh T, Dingledine R. Preclinical development of an EP2 antagonist for post-seizure cognitive deficits. Neuropharmacology. 224: 109356. PMID 36460083 DOI: 10.1016/j.neuropharm.2022.109356  0.708
2020 Varvel NH, Espinosa-Garcia C, Hunter-Chang S, Chen D, Biegel A, Hsieh A, Blackmer-Raynolds L, Ganesh T, Dingledine R. Peripheral myeloid cell EP2 activation contributes to the deleterious consequences of status epilepticus. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 33293358 DOI: 10.1523/JNEUROSCI.2040-20.2020  0.763
2019 Varvel NH, Ransohoff RM, Neher JJ. Functional Analysis of Brain-Engrafted Monocytes After Microglia Ablation in Mouse Models. Methods in Molecular Biology (Clifton, N.J.). 2034: 293-301. PMID 31392694 DOI: 10.1007/978-1-4939-9658-2_22  0.399
2019 Manji Z, Rojas A, Wang W, Dingledine R, Varvel NH, Ganesh N. 5xFAD Mice Display Sex-Dependent Inflammatory Gene Induction During the Prodromal Stage of Alzheimer's Disease. Journal of Alzheimer's Disease : Jad. PMID 31322556 DOI: 10.3233/Jad-180678  0.714
2018 Rojas A, Chen D, Ganesh T, Varvel NH, Dingledine R. The COX-2/prostanoid signaling cascades in seizure disorders. Expert Opinion On Therapeutic Targets. PMID 30484341 DOI: 10.1080/14728222.2019.1554056  0.746
2016 Varvel NH, Neher JJ, Bosch A, Wang W, Ransohoff RM, Miller RJ, Dingledine R. Infiltrating monocytes promote brain inflammation and exacerbate neuronal damage after status epilepticus. Proceedings of the National Academy of Sciences of the United States of America. PMID 27601660 DOI: 10.1073/Pnas.1604263113  0.641
2015 Varvel NH, Grathwohl SA, Degenhardt K, Resch C, Bosch A, Jucker M, Neher JJ. Replacement of brain-resident myeloid cells does not alter cerebral amyloid-β deposition in mouse models of Alzheimer's disease. The Journal of Experimental Medicine. 212: 1803-9. PMID 26458770 DOI: 10.1084/Jem.20150478  0.658
2015 Varvel NH, Jiang J, Dingledine R. Candidate drug targets for prevention or modification of epilepsy. Annual Review of Pharmacology and Toxicology. 55: 229-47. PMID 25196047 DOI: 10.1146/Annurev-Pharmtox-010814-124607  0.712
2014 Dingledine R, Varvel NH, Dudek FE. When and how do seizures kill neurons, and is cell death relevant to epileptogenesis? Advances in Experimental Medicine and Biology. 813: 109-22. PMID 25012371 DOI: 10.1007/978-94-017-8914-1_9  0.585
2014 Bhaskar K, Maphis N, Xu G, Varvel NH, Kokiko-Cochran ON, Weick JP, Staugaitis SM, Cardona A, Ransohoff RM, Herrup K, Lamb BT. Microglial derived tumor necrosis factor-α drives Alzheimer's disease-related neuronal cell cycle events. Neurobiology of Disease. 62: 273-85. PMID 24141019 DOI: 10.1016/J.Nbd.2013.10.007  0.765
2012 Varvel NH, Grathwohl SA, Baumann F, Liebig C, Bosch A, Brawek B, Thal DR, Charo IF, Heppner FL, Aguzzi A, Garaschuk O, Ransohoff RM, Jucker M. Microglial repopulation model reveals a robust homeostatic process for replacing CNS myeloid cells. Proceedings of the National Academy of Sciences of the United States of America. 109: 18150-5. PMID 23071306 DOI: 10.1073/Pnas.1210150109  0.642
2012 Hamaguchi T, Eisele YS, Varvel NH, Lamb BT, Walker LC, Jucker M. The presence of Aβ seeds, and not age per se, is critical to the initiation of Aβ deposition in the brain. Acta Neuropathologica. 123: 31-7. PMID 22101366 DOI: 10.1007/S00401-011-0912-1  0.708
2012 Wilkinson BL, Cramer PE, Varvel NH, Reed-Geaghan E, Jiang Q, Szabo A, Herrup K, Lamb BT, Landreth GE. Ibuprofen attenuates oxidative damage through NOX2 inhibition in Alzheimer's disease. Neurobiology of Aging. 33: 197.e21-32. PMID 20696495 DOI: 10.1016/J.Neurobiolaging.2010.06.014  0.71
2012 Bhaskar K, Maphis N, Varvel N, Kokiko-Cochran O, Ransohoff R, Herrup K, Lamb B. P161 Cell-autonomous effect of microglia on the induction of Alzheimer’s disease neuronal cell cycle events Cytokine. 59: 571. DOI: 10.1016/J.Cyto.2012.06.262  0.745
2010 Lee S, Varvel NH, Konerth ME, Xu G, Cardona AE, Ransohoff RM, Lamb BT. CX3CR1 deficiency alters microglial activation and reduces beta-amyloid deposition in two Alzheimer's disease mouse models. The American Journal of Pathology. 177: 2549-62. PMID 20864679 DOI: 10.2353/Ajpath.2010.100265  0.687
2010 Edwards MM, Marín de Evsikova C, Collin GB, Gifford E, Wu J, Hicks WL, Whiting C, Varvel NH, Maphis N, Lamb BT, Naggert JK, Nishina PM, Peachey NS. Photoreceptor degeneration, azoospermia, leukoencephalopathy, and abnormal RPE cell function in mice expressing an early stop mutation in CLCN2. Investigative Ophthalmology & Visual Science. 51: 3264-72. PMID 20071672 DOI: 10.1167/Iovs.09-4887  0.574
2010 Lamb BT, Bhaskar K, Lee S, Varvel NH, Konerth ME, Kokiko-Cochran ON, Cardona AE, Ransohoff RM. S4-03-04: The Opposing Roles of Fractalkine Signaling in Alzheimer's Disease Pathogenesis Alzheimer's & Dementia. 6: e14-e14. DOI: 10.1016/J.Jalz.2010.08.043  0.597
2009 Varvel NH, Bhaskar K, Kounnas MZ, Wagner SL, Yang Y, Lamb BT, Herrup K. NSAIDs prevent, but do not reverse, neuronal cell cycle reentry in a mouse model of Alzheimer disease. The Journal of Clinical Investigation. 119: 3692-702. PMID 19907078 DOI: 10.1172/Jci39716  0.748
2009 Muresan V, Varvel NH, Lamb BT, Muresan Z. The cleavage products of amyloid-beta precursor protein are sorted to distinct carrier vesicles that are independently transported within neurites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 3565-78. PMID 19295161 DOI: 10.1523/Jneurosci.2558-08.2009  0.607
2008 Varvel NH, Bhaskar K, Patil AR, Pimplikar SW, Herrup K, Lamb BT. Abeta oligomers induce neuronal cell cycle events in Alzheimer's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 10786-93. PMID 18945886 DOI: 10.1523/Jneurosci.2441-08.2008  0.737
2006 Yang Y, Varvel NH, Lamb BT, Herrup K. Ectopic cell cycle events link human Alzheimer's disease and amyloid precursor protein transgenic mouse models. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 775-84. PMID 16421297 DOI: 10.1523/Jneurosci.3707-05.2006  0.726
2006 Lamb BT, Ryman DC, Schrump S, Varvel N. P1-123: Modifiers of Alzheimer's disease phenotypes in the mouse Alzheimer's & Dementia. 2: S131-S132. DOI: 10.1016/j.jalz.2006.05.499  0.565
2004 Moss MA, Varvel NH, Nichols MR, Reed DK, Rosenberry TL. Nordihydroguaiaretic acid does not disaggregate beta-amyloid(1-40) protofibrils but does inhibit growth arising from direct protofibril association. Molecular Pharmacology. 66: 592-600. PMID 15322251 DOI: 10.1124/Mol.66.3  0.33
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