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Jin Zhang, Ph.D. - Publications

Affiliations: 
Pharmacology Johns Hopkins University, Baltimore, MD 
Area:
FRET, cell signaling
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Year Citation  Score
2024 Su Q, Zhang J, Lin W, Zhang JF, Newton AC, Mehta S, Yang J, Zhang J. Sensitive Fluorescent Biosensor Reveals Differential Subcellular Regulation of PKC. Biorxiv : the Preprint Server For Biology. PMID 38586003 DOI: 10.1101/2024.03.29.587373  0.439
2024 Lin W, Phatarphekar A, Zhong Y, Liu L, Kwon HB, Gerwick WH, Wang Y, Mehta S, Zhang J. Light-gated Integrator for Highlighting Kinase Activity in Living Cells. Biorxiv : the Preprint Server For Biology. PMID 38562887 DOI: 10.1101/2024.03.18.585554  0.476
2024 Hardy JC, Pool EH, Bruystens JGH, Zhou X, Li Q, Zhou DR, Palay M, Tan G, Chen L, Choi JLC, Lee HN, Strack S, Wang D, Taylor SS, Mehta S, ... Zhang J, et al. Molecular determinants and signaling effects of PKA RIα phase separation. Molecular Cell. PMID 38537638 DOI: 10.1016/j.molcel.2024.03.002  0.395
2024 Frei MS, Sanchez SA, Liu L, Schneider F, Wang Z, Hakozaki H, Li Y, Lyons AC, Rohm TV, Olefsky JM, Shi L, Schöneberg J, Fraser SE, Mehta S, Wang Y, ... Zhang J, et al. Far-red chemigenetic biosensors for multi-dimensional and super-resolved kinase activity imaging. Biorxiv : the Preprint Server For Biology. PMID 38370804 DOI: 10.1101/2024.02.10.579766  0.35
2023 Hardy JC, Pool EH, Bruystens JGH, Zhou X, Li Q, Zhou DR, Palay M, Tan G, Chen L, Choi JLC, Lee HN, Strack S, Wang D, Taylor SS, Mehta S, ... Zhang J, et al. Molecular Determinants and Signaling Effects of PKA RIα Phase Separation. Biorxiv : the Preprint Server For Biology. PMID 38168176 DOI: 10.1101/2023.12.10.570836  0.389
2023 Lyons AC, Mehta S, Zhang J. Fluorescent biosensors illuminate the spatial regulation of cell signaling across scales. The Biochemical Journal. 480: 1693-1717. PMID 37903110 DOI: 10.1042/BCJ20220223  0.351
2023 Posner C, Mehta S, Zhang J. Fluorescent biosensor imaging meets deterministic mathematical modelling: quantitative investigation of signalling compartmentalization. The Journal of Physiology. 601: 4227-4241. PMID 37747358 DOI: 10.1113/JP282696  0.402
2023 Willette BKA, Zhang JF, Zhang J, Tsvetanova NG. Endosome positioning coordinates spatially selective GPCR signaling. Nature Chemical Biology. PMID 37500769 DOI: 10.1038/s41589-023-01390-7  0.375
2023 Elias RD, Zhu Y, Su Q, Ghirlando R, Zhang J, Deshmukh L. Reversible phase separation of ESCRT protein ALIX through tyrosine phosphorylation. Science Advances. 9: eadg3913. PMID 37450591 DOI: 10.1126/sciadv.adg3913  0.305
2023 Greenwald E, Posner C, Bharath A, Lyons A, Salmerón C, Sriram K, Wiley SZ, Insel PA, Zhang J. GPCR Signaling Measurement and Drug Profiling with an Automated Live-Cell Microscopy System. Acs Sensors. PMID 36602887 DOI: 10.1021/acssensors.2c01341  0.783
2022 Peng Q, Huang Z, Sun K, Liu Y, Yoon CW, Harrison RES, Schmitt DL, Zhu L, Wu Y, Tasan I, Zhao H, Zhang J, Zhong S, Chien S, Wang Y. Engineering inducible biomolecular assemblies for genome imaging and manipulation in living cells. Nature Communications. 13: 7933. PMID 36566209 DOI: 10.1038/s41467-022-35504-x  0.645
2022 Schmitt DL, Mehta S, Zhang J. Study of spatiotemporal regulation of kinase signaling using genetically encodable molecular tools. Current Opinion in Chemical Biology. 71: 102224. PMID 36347198 DOI: 10.1016/j.cbpa.2022.102224  0.741
2022 Kwon Y, Mehta S, Clark M, Walters G, Zhong Y, Lee HN, Sunahara RK, Zhang J. Non-canonical β-adrenergic activation of ERK at endosomes. Nature. PMID 36289326 DOI: 10.1038/s41586-022-05343-3  0.419
2022 Hashizume R, Fujii H, Mehta S, Ota K, Qian Y, Zhu W, Drobizhev M, Nasu Y, Zhang J, Bito H, Campbell RE. A genetically encoded far-red fluorescent calcium ion biosensor derived from a biliverdin-binding protein. Protein Science : a Publication of the Protein Society. 31: e4440. PMID 36173169 DOI: 10.1002/pro.4440  0.492
2022 Schmitt DL, Curtis SD, Lyons AC, Zhang JF, Chen M, He CY, Mehta S, Shaw RJ, Zhang J. Spatial regulation of AMPK signaling revealed by a sensitive kinase activity reporter. Nature Communications. 13: 3856. PMID 35790710 DOI: 10.1038/s41467-022-31190-x  0.749
2022 Zhou X, Mehta S, Zhang J. AktAR and Akt-STOPS: Genetically Encodable Molecular Tools to Visualize and Perturb Akt Kinase Activity at Different Subcellular Locations in Living Cells. Current Protocols. 2: e416. PMID 35532280 DOI: 10.1002/cpz1.416  0.457
2022 Hardy JC, Mehta S, Zhang J. Measuring Spatiotemporal cAMP Dynamics Within an Endogenous Signaling Compartment Using FluoSTEP-ICUE. Methods in Molecular Biology (Clifton, N.J.). 2483: 351-366. PMID 35286687 DOI: 10.1007/978-1-0716-2245-2_22  0.398
2022 Zhang JF, Mehta S, Zhang J. Protocol for reading and imaging live-cell PKA activity using ExRai-AKAR2. Star Protocols. 3: 101071. PMID 35036953 DOI: 10.1016/j.xpro.2021.101071  0.353
2021 Chen M, Sun T, Zhong Y, Zhou X, Zhang J. A Highly Sensitive Fluorescent Akt Biosensor Reveals Lysosome-Selective Regulation of Lipid Second Messengers and Kinase Activity. Acs Central Science. 7: 2009-2020. PMID 34963894 DOI: 10.1021/acscentsci.1c00919  0.397
2021 Liu L, Limsakul P, Meng X, Huang Y, Harrison RES, Huang TS, Shi Y, Yu Y, Charupanit K, Zhong S, Lu S, Zhang J, Chien S, Sun J, Wang Y. Integration of FRET and sequencing to engineer kinase biosensors from mammalian cell libraries. Nature Communications. 12: 5031. PMID 34413312 DOI: 10.1038/s41467-021-25323-x  0.31
2021 Keyes J, Mehta S, Zhang J. Strategies for Multiplexed Biosensor Imaging to Study Intracellular Signaling Networks. Methods in Molecular Biology (Clifton, N.J.). 2350: 1-20. PMID 34331275 DOI: 10.1007/978-1-0716-1593-5_1  0.332
2021 Zhao S, Geng Y, Cao L, Yang Q, Pan T, Zhou D, Liu J, Shi Z, Zhang J. Deciphering the performance of polo-like kinase 1 in triple-negative breast cancer progression according to the centromere protein U-phosphorylation pathway. American Journal of Cancer Research. 11: 2142-2158. PMID 34094674  0.304
2021 Tenner B, Zhang JZ, Kwon Y, Pessino V, Feng S, Huang B, Mehta S, Zhang J. FluoSTEPs: Fluorescent biosensors for monitoring compartmentalized signaling within endogenous microdomains. Science Advances. 7. PMID 34020947 DOI: 10.1126/sciadv.abe4091  0.423
2021 Mehta S, Zhang J. Biochemical Activity Architectures Visualized-Using Genetically Encoded Fluorescent Biosensors to Map the Spatial Boundaries of Signaling Compartments. Accounts of Chemical Research. PMID 33949851 DOI: 10.1021/acs.accounts.1c00056  0.431
2021 Roebroek T, Vandenberg W, Sipieter F, Hugelier S, Stove C, Zhang J, Dedecker P. Simultaneous readout of multiple FRET pairs using photochromism. Nature Communications. 12: 2005. PMID 33790271 DOI: 10.1038/s41467-021-22043-0  0.337
2021 Zhang JF, Mehta S, Zhang J. Signaling Microdomains in the Spotlight: Visualizing Compartmentalized Signaling Using Genetically Encoded Fluorescent Biosensors. Annual Review of Pharmacology and Toxicology. 61: 587-608. PMID 33411579 DOI: 10.1146/annurev-pharmtox-010617-053137  0.356
2020 Tenner B, Getz M, Ross B, Ohadi D, Bohrer CH, Greenwald E, Mehta S, Xiao J, Rangamani P, Zhang J. Spatially compartmentalized phase regulation of a Ca-cAMP-PKA oscillatory circuit. Elife. 9. PMID 33201801 DOI: 10.7554/eLife.55013  0.735
2020 Zhang JF, Liu B, Hong I, Mo A, Roth RH, Tenner B, Lin W, Zhang JZ, Molina RS, Drobizhev M, Hughes TE, Tian L, Huganir RL, Mehta S, Zhang J. An ultrasensitive biosensor for high-resolution kinase activity imaging in awake mice. Nature Chemical Biology. PMID 32989297 DOI: 10.1038/s41589-020-00660-y  0.47
2020 Zhang JZ, Nguyen AH, Miyamoto S, Heller Brown J, McCulloch AD, Zhang J. Histamine-induced biphasic activation of RhoA allows for persistent RhoA signaling. Plos Biology. 18: e3000866. PMID 32881857 DOI: 10.1371/Journal.Pbio.3000866  0.488
2020 Zhang JZ, Lu TW, Stolerman LM, Tenner B, Yang JR, Zhang JF, Falcke M, Rangamani P, Taylor SS, Mehta S, Zhang J. Phase Separation of a PKA Regulatory Subunit Controls cAMP Compartmentation and Oncogenic Signaling. Cell. PMID 32846158 DOI: 10.1016/J.Cell.2020.07.043  0.508
2020 Zhou X, Mehta S, Zhang J. Genetically Encodable Fluorescent and Bioluminescent Biosensors Light Up Signaling Networks. Trends in Biochemical Sciences. PMID 32660810 DOI: 10.1016/J.Tibs.2020.06.001  0.416
2020 Keyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Zhang J, Ling M, Trejo J, Levchenko A, Zhang J. Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics. Elife. 9. PMID 32452765 DOI: 10.7554/Elife.57410  0.501
2020 Mo GCH, Posner C, Rodriguez EA, Sun T, Zhang J. A rationally enhanced red fluorescent protein expands the utility of FRET biosensors. Nature Communications. 11: 1848. PMID 32296061 DOI: 10.1038/S41467-020-15687-X  0.774
2020 Lee HN, Mehta S, Zhang J. Recent advances in the use of genetically encodable optical tools to elicit and monitor signaling events. Current Opinion in Cell Biology. 63: 114-124. PMID 32058267 DOI: 10.1016/J.Ceb.2020.01.007  0.451
2020 Chan TO, Armen RS, Yadav S, Shah S, Zhang J, Tiegs BC, Keny N, Blumhof B, Deshpande DA, Rodeck U, Penn RB. A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation. The Journal of Biological Chemistry. PMID 31964716 DOI: 10.1074/Jbc.Ra119.010004  0.372
2020 Schmitt DL, Mehta S, Zhang J. Illuminating the kinome: Visualizing real-time kinase activity in biological systems using genetically encoded fluorescent protein-based biosensors. Current Opinion in Chemical Biology. 54: 63-69. PMID 31911398 DOI: 10.1016/J.Cbpa.2019.11.005  0.83
2020 Keyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Zhang J, Ling M, Trejo J, Levchenko A, Zhang J. Author response: Signaling diversity enabled by Rap1-regulated plasma membrane ERK with distinct temporal dynamics Elife. DOI: 10.7554/Elife.57410.Sa2  0.384
2020 Kwon Y, Clark MJ, Keyes J, Walters G, Sunahara RK, Zhang J. Spatiotemporal Control of ERK Activity by b 2 ‐adrenergic Signaling The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07537  0.369
2020 Zhong Y, Zhou X, Guan K, Zhang J. Constitutively Active Rheb Regulates Nuclear mTORC1 Activity and Function The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.07130  0.366
2020 Lin W, Phatarphekar A, Greenwald EC, Zhang J. A Light‐gated Integrator for Imaging Kinase Activity in Living Cells The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.05541  0.78
2020 Zhou X, Zhong Y, Kunkel MT, Newton AC, Zhang J. Tracking mTORC1 Activity in the Nucleus: Distinct Regulation Revealed by Locationspecific Inhibition of Akt The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04692  0.358
2020 Garcia A, Molinar-Inglis O, Nicholas D, Keyes J, Adame J, Cisneros M, Lawson M, Zhang J, Trejo J. Improved fractionation method demonstrates phosphorylated Akt is localized to the cytoplasm in LβT2 cells The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04608  0.381
2020 Mehta S, Zhang J, Liu B, Hong I, Tenner B, Lin W, Huganir RL, Zhang J. An Ultrasensitive Fluorescent Biosensor for Multi‐modal Kinase Activity Detection and High‐resolution Imaging in Awake Mice The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.04082  0.397
2020 Zhang JZ, Lu T, Tenner B, Yang J, Zhang J, Taylor S, Mehta S, Zhang J. PKA RIα phase separation drives cAMP compartmentation and suppresses tumorigenic signaling The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03204  0.355
2020 Schmitt DL, Zhang J, Chen M, Leung A, He CY, Curtis SD, Mehta S, Shaw RJ, Rangamani P, Zhang J. Illuminating Spatiotemporal Regulation of AMPK with a Genetically Encoded Excitation‐Ratiometric Biosensor for AMPK The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.03063  0.678
2020 Keyes J, Ganesan A, Molinar-Inglis O, Hamidzadeh A, Ling M, Trejo J, Levchenko A, Zhang J. Signaling Diversity Enabled by Rap1 and cAMP/PKA‐Regulated Plasma Membrane ERK with Distinct Temporal Dynamics The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00680  0.384
2020 Zhang J. Illuminating the Biochemical Activity Architecture of the Cell The Faseb Journal. 34: 1-1. DOI: 10.1096/Fasebj.2020.34.S1.00385  0.356
2019 Qin Q, Laub S, Shi Y, Ouyang M, Peng Q, Zhang J, Wang Y, Lu S. for Ratiometric and High-Throughput Live-Cell Image Visualization and Quantitation. Frontiers in Physics. 7. PMID 33163483 DOI: 10.3389/Fphy.2019.00154  0.414
2019 Hertel F, Li S, Chen M, Pott L, Mehta S, Zhang J. Fluorescent biosensors for multiplexed imaging of phosphoinositide dynamics. Acs Chemical Biology. PMID 31855412 DOI: 10.1021/Acschembio.9B00691  0.475
2019 Ohadi D, Schmitt DL, Calabrese B, Halpain S, Zhang J, Rangamani P. Computational Modeling Reveals Frequency Modulation of Calcium-cAMP/PKA Pathway in Dendritic Spines. Biophysical Journal. PMID 31668749 DOI: 10.1016/J.Bpj.2019.10.003  0.785
2019 Lin W, Mehta S, Zhang J. Genetically encoded fluorescent biosensors illuminate kinase signaling in cancer. The Journal of Biological Chemistry. PMID 31434714 DOI: 10.1074/Jbc.Rev119.006177  0.515
2019 Ross B, Wong SH, Snell NE, Zhang J, Rizzo MA. Triple Fluorescence Anisotropy Reporter Imaging in Living Cells. Bio-Protocol. 9. PMID 31423459 DOI: 10.21769/BioProtoc.3226  0.335
2019 Clister T, Greenwald EC, Baillie GS, Zhang J. AKAP95 Organizes a Nuclear Microdomain to Control Local cAMP for Regulating Nuclear PKA. Cell Chemical Biology. PMID 30982750 DOI: 10.1016/J.Chembiol.2019.03.003  0.786
2019 He M, Huang TS, Li S, Hong HC, Chen Z, Martin M, Zhou X, Huang HY, Su SH, Zhang J, Wang WT, Kang J, Huang HD, Zhang J, Chien S, et al. Atheroprotective Flow Upregulates ITPR3 (Inositol 1,4,5-Trisphosphate Receptor 3) in Vascular Endothelium via KLF4 (Krüppel-Like Factor 4)-Mediated Histone Modifications. Arteriosclerosis, Thrombosis, and Vascular Biology. ATVBAHA118312301. PMID 30917677 DOI: 10.1161/Atvbaha.118.312301  0.303
2019 Qian Y, Piatkevich KD, Mc Larney B, Abdelfattah AS, Mehta S, Murdock MH, Gottschalk S, Molina RS, Zhang W, Chen Y, Wu J, Drobizhev M, Hughes TE, Zhang J, Schreiter ER, et al. A genetically encoded near-infrared fluorescent calcium ion indicator. Nature Methods. PMID 30664778 DOI: 10.1038/S41592-018-0294-6  0.498
2018 Greenwald EC, Mehta S, Zhang J. Genetically Encoded Fluorescent Biosensors Illuminate the Spatiotemporal Regulation of Signaling Networks. Chemical Reviews. PMID 30550275 DOI: 10.1021/Acs.Chemrev.8B00333  0.789
2018 Mehta S, Zhang Y, Roth RH, Zhang JF, Mo A, Tenner B, Huganir RL, Zhang J. Single-fluorophore biosensors for sensitive and multiplexed detection of signalling activities. Nature Cell Biology. 20: 1215-1225. PMID 30250062 DOI: 10.1038/S41556-018-0200-6  0.475
2018 Grimsey NJ, Narala R, Rada CC, Mehta S, Stephens BS, Kufareva I, Lapek J, Gonzalez DJ, Handel TM, Zhang J, Trejo J. A Tyrosine Switch on NEDD4-2 E3 Ligase Transmits GPCR Inflammatory Signaling. Cell Reports. 24: 3312-3323.e5. PMID 30232011 DOI: 10.1016/J.Celrep.2018.08.061  0.448
2018 Liu SL, Wang ZG, Hu Y, Xin Y, Singaram I, Gorai S, Zhou X, Shim Y, Min JH, Gong LW, Hay N, Zhang J, Cho W. Quantitative Lipid Imaging Reveals a New Signaling Function of Phosphatidylinositol-3,4-Bisphophate: Isoform- and Site-Specific Activation of Akt. Molecular Cell. PMID 30174291 DOI: 10.1016/J.Molcel.2018.07.035  0.493
2018 Zhang J, Liu J, Ren L, Wei J, Zhang F, Li Y, Guo C, Duan J, Sun Z, Zhou X. Silica nanoparticles induce abnormal mitosis and apoptosis via PKC-δ mediated negative signaling pathway in GC-2 cells of mice. Chemosphere. 208: 942-950. PMID 30068038 DOI: 10.1016/j.chemosphere.2018.05.178  0.301
2018 Ross BL, Tenner B, Markwardt ML, Zviman A, Shi G, Kerr JP, Snell NE, McFarland JJ, Mauban JR, Ward CW, Rizzo MA, Zhang J. Single-color, ratiometric biosensors for detecting signaling activities in live cells. Elife. 7. PMID 29968564 DOI: 10.7554/Elife.35458  0.46
2018 Hertel F, Mo GCH, Dedecker P, Zhang J. Observing the Assembly of Protein Complexes in Living Eukaryotic Cells in Super-Resolution Using refSOFI. Methods in Molecular Biology (Clifton, N.J.). 1764: 267-277. PMID 29605920 DOI: 10.1007/978-1-4939-7759-8_16  0.36
2018 Oldach LM, Gorshkov K, Mills WT, Zhang J, Meffert MK. A Biosensor for MAPK-Dependent Lin28 Signaling. Molecular Biology of the Cell. PMID 29540527 DOI: 10.1091/Mbc.E17-08-0500  0.469
2018 Ross BL, Tenner B, Markwardt ML, Zviman A, Shi G, Kerr JP, Snell NE, McFarland JJ, Mauban JR, Ward CW, Rizzo MA, Zhang J. Author response: Single-color, ratiometric biosensors for detecting signaling activities in live cells Elife. DOI: 10.7554/Elife.35458.037  0.396
2018 Zhang J. Illuminating the Biochemical Activity Architecture of the Cell Biophysical Journal. 114. DOI: 10.1016/J.Bpj.2017.11.2223  0.356
2017 Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD. Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity. Elife. 6. PMID 28967377 DOI: 10.7554/Elife.30872  0.369
2017 Chen Y, Booth C, Wang H, Wang R, Terzi D, Zachariou V, Jiao K, Zhang J, Wang Q. Effective attenuation of adenosine A1R signaling by neurabin requires oligomerization of neurabin. Molecular Pharmacology. PMID 28954816 DOI: 10.1124/Mol.117.109462  0.396
2017 Mehta S, Zhang J. Illuminating the cell's biochemical activity architecture. Biochemistry. PMID 28718621 DOI: 10.1021/Acs.Biochem.7B00561  0.432
2017 Ni Q, Mehta S, Zhang J. Live-cell imaging of cell signaling using genetically encoded fluorescent reporters. The Febs Journal. PMID 28613457 DOI: 10.1111/Febs.14134  0.485
2017 Newman RH, Zhang J. Integrated Strategies to Gain a Systems-Level View of Dynamic Signaling Networks. Methods in Enzymology. 589: 133-170. PMID 28336062 DOI: 10.1016/Bs.Mie.2017.01.016  0.401
2017 Mo GC, Ross B, Hertel F, Manna P, Yang X, Greenwald E, Booth C, Plummer AM, Tenner B, Chen Z, Wang Y, Kennedy EJ, Cole PA, Fleming KG, Palmer A, ... Zhang J, et al. Genetically encoded biosensors for visualizing live-cell biochemical activity at super-resolution. Nature Methods. PMID 28288122 DOI: 10.1038/Nmeth.4221  0.836
2017 Gorshkov K, Mehta S, Ramamurthy S, Ronnett GV, Zhou FQ, Zhang J. AKAP-mediated feedback control of cAMP gradients in developing hippocampal neurons. Nature Chemical Biology. PMID 28192412 DOI: 10.1038/Nchembio.2298  0.368
2016 Zhou X, Li S, Zhang J. Tracking the Activity of mTORC1 in Living Cells Using Genetically Encoded FRET-based Biosensor TORCAR. Current Protocols in Chemical Biology. 8: 225-233. PMID 27925667 DOI: 10.1002/Cpch.11  0.505
2016 Rodriguez EA, Campbell RE, Lin JY, Lin MZ, Miyawaki A, Palmer AE, Shu X, Zhang J, Tsien RY. The Growing and Glowing Toolbox of Fluorescent and Photoactive Proteins. Trends in Biochemical Sciences. PMID 27814948 DOI: 10.1016/J.Tibs.2016.09.010  0.772
2016 Moore BS, Stepanchick AN, Tewson PH, Hartle CM, Zhang J, Quinn AM, Hughes TE, Mirshahi T. Cilia have high cAMP levels that are inhibited by Sonic Hedgehog-regulated calcium dynamics. Proceedings of the National Academy of Sciences of the United States of America. PMID 27799542 DOI: 10.1073/Pnas.1602393113  0.506
2016 Zhang J, Gao G, Begum G, Wang J, Khanna AR, Shmukler BE, Daubner GM, de Los Heros P, Davies P, Varghese J, Bhuiyan MI, Duan J, Zhang J, Duran D, Alper SL, et al. Functional kinomics establishes a critical node of volume-sensitive cation-Cl(-) cotransporter regulation in the mammalian brain. Scientific Reports. 6: 35986. PMID 27782176 DOI: 10.1038/Srep35986  0.324
2016 Behar J, Ganesan A, Zhang J, Yaniv Y. The Autonomic Nervous System Regulates the Heart Rate through cAMP-PKA Dependent and Independent Coupled-Clock Pacemaker Cell Mechanisms. Frontiers in Physiology. 7: 419. PMID 27729868 DOI: 10.3389/Fphys.2016.00419  0.405
2016 Palmer AE, Zhang J. Roger Y. Tsien 1952-2016. Nature Chemical Biology. PMID 27669418 DOI: 10.1038/Nchembio.2213  0.545
2016 Conlon P, Gelin-Licht R, Ganesan A, Zhang J, Levchenko A. Single-cell dynamics and variability of MAPK activity in a yeast differentiation pathway. Proceedings of the National Academy of Sciences of the United States of America. PMID 27651485 DOI: 10.1073/Pnas.1610081113  0.46
2016 Ross B, Mehta S, Zhang J. Molecular tools for acute spatiotemporal manipulation of signal transduction. Current Opinion in Chemical Biology. 34: 135-142. PMID 27639090 DOI: 10.1016/J.Cbpa.2016.08.012  0.422
2016 Tenner B, Mehta S, Zhang J. Optical sensors to gain mechanistic insights into signaling assemblies. Current Opinion in Structural Biology. 41: 203-210. PMID 27611602 DOI: 10.1016/J.Sbi.2016.07.021  0.41
2016 Hung WC, Yang JR, Yankaskas CL, Wong BS, Wu PH, Pardo-Pastor C, Serra SA, Chiang MJ, Gu Z, Wirtz D, Valverde MA, Yang JT, Zhang J, Konstantopoulos K. Confinement-Sensing and Signal Optimization via Piezo1/PKA and Myosin II Pathways. Cell Reports. PMID 27160899 DOI: 10.1016/J.Celrep.2016.04.035  0.435
2016 Hertel F, Zhang J. Monitoring of post-translational modification dynamics with genetically encoded fluorescent reporters. Biopolymers. 101: 180-7. PMID 23576192 DOI: 10.1002/bip.22254  0.337
2016 Hertel F, Zhang J. A New Class of Targetable, Genetically Encoded Single-Color Biosensors for Multiplexed Monitoring of Phosphoinositides Biophysical Journal. 110: 336. DOI: 10.1016/J.Bpj.2015.11.1809  0.426
2015 Hertel F, Mo GC, Duwé S, Dedecker P, Zhang J. RefSOFI for Mapping Nanoscale Organization of Protein-Protein Interactions in Living Cells. Cell Reports. PMID 26748717 DOI: 10.1016/J.Celrep.2015.12.036  0.367
2015 Head SA, Shi W, Zhao L, Gorshkov K, Pasunooti K, Chen Y, Deng Z, Li RJ, Shim JS, Tan W, Hartung T, Zhang J, Zhao Y, Colombini M, Liu JO. Antifungal drug itraconazole targets VDAC1 to modulate the AMPK/mTOR signaling axis in endothelial cells. Proceedings of the National Academy of Sciences of the United States of America. PMID 26655341 DOI: 10.1073/Pnas.1512867112  0.408
2015 Depry C, Mehta S, Li R, Zhang J. Visualization of Compartmentalized Kinase Activity Dynamics Using Adaptable BimKARs. Chemistry & Biology. PMID 26548610 DOI: 10.1016/J.Chembiol.2015.10.004  0.832
2015 Hu J, Neiswinger J, Zhang J, Zhu H, Qian J. Systematic Prediction of Scaffold Proteins Reveals New Design Principles in Scaffold-Mediated Signal Transduction. Plos Computational Biology. 11: e1004508. PMID 26393507 DOI: 10.1371/Journal.Pcbi.1004508  0.408
2015 Yaniv Y, Ganesan A, Yang D, Ziman BD, Lyashkov AE, Levchenko A, Zhang J, Lakatta EG. Real-time relationship between PKA biochemical signal network dynamics and increased action potential firing rate in heart pacemaker cells: Yaniv. Kinetics of PKA activation in heart pacemaker cells. Journal of Molecular and Cellular Cardiology. PMID 26241846 DOI: 10.1016/J.Yjmcc.2015.07.024  0.405
2015 Chan TO, Zhang J, Tiegs BC, Blumhof B, Yan L, Keny N, Penny M, Li X, Pascal JM, Armen RS, Rodeck U, Penn RB. Akt Kinase C-Terminal Modifications Control Activation Loop Dephosphorylation and Enhance Insulin Response. The Biochemical Journal. PMID 26201515 DOI: 10.1042/Bj20150325  0.337
2015 Karlsson I, Zhou X, Thomas R, Smith AT, Bonner MY, Bakshi P, Banga AK, Bowen JP, Qabaja G, Ford SL, Ballard MD, Petersen KS, Li X, Chen G, Ogretmen B, ... Zhang J, et al. Solenopsin A and analogs exhibit ceramide-like biological activity. Vascular Cell. 7: 5. PMID 26015865 DOI: 10.1186/S13221-015-0030-2  0.383
2015 Mehta S, Zhang J. Light moves mountains in the cell. Chemistry & Biology. 22: 569-70. PMID 26000746 DOI: 10.1016/J.Chembiol.2015.05.002  0.329
2015 Miyamoto T, Rho E, Sample V, Akano H, Magari M, Ueno T, Gorshkov K, Chen M, Tokumitsu H, Zhang J, Inoue T. Compartmentalized AMPK signaling illuminated by genetically encoded molecular sensors and actuators. Cell Reports. 11: 657-70. PMID 25892241 DOI: 10.1016/J.Celrep.2015.03.057  0.83
2015 Sample V, Ramamurthy S, Gorshkov K, Ronnett GV, Zhang J. Polarized activities of AMPK and BRSK in primary hippocampal neurons. Molecular Biology of the Cell. 26: 1935-46. PMID 25788287 DOI: 10.1091/Mbc.E14-02-0764  0.783
2015 Zhou X, Clister TL, Lowry PR, Seldin MM, Wong GW, Zhang J. Dynamic Visualization of mTORC1 Activity in Living Cells. Cell Reports. PMID 25772363 DOI: 10.1016/J.Celrep.2015.02.031  0.465
2015 Mehta S, Zhang J. Dynamic visualization of calcium-dependent signaling in cellular microdomains. Cell Calcium. PMID 25703691 DOI: 10.1016/J.Ceca.2015.01.009  0.416
2015 Ding Y, Li J, Enterina JR, Shen Y, Zhang I, Tewson PH, Mo GC, Zhang J, Quinn AM, Hughes TE, Maysinger D, Alford SC, Zhang Y, Campbell RE. Ratiometric biosensors based on dimerization-dependent fluorescent protein exchange. Nature Methods. 12: 195-8. PMID 25622108 DOI: 10.1038/Nmeth.3261  0.679
2015 Clister T, Mehta S, Zhang J. Single-cell analysis of G-protein signal transduction. The Journal of Biological Chemistry. 290: 6681-8. PMID 25605723 DOI: 10.1074/Jbc.R114.616391  0.463
2015 Dou H, Wang C, Wu X, Yao L, Zhang X, Teng S, Xu H, Liu B, Wu Q, Zhang Q, Hu M, Wang Y, Wang L, Wu Y, Shang S, ... Zhang J, et al. Calcium influx activates adenylyl cyclase 8 for sustained insulin secretion in rat pancreatic beta cells. Diabetologia. 58: 324-33. PMID 25381556 DOI: 10.1007/S00125-014-3437-Z  0.352
2015 Zhang J. Compartmentalized PI3K/Akt/mTOR Signaling in Living Cells The Faseb Journal. 29. DOI: 10.1096/Fasebj.29.1_Supplement.234.3  0.439
2015 Hertel F, Mo G, Duwé S, Dedecker P, Zhang J. Refsofi for Imaging Protein-Protein Interactions in Living Cells in Super-Resolution Biophysical Journal. 108: 360. DOI: 10.1016/J.Bpj.2014.11.1977  0.405
2015 Mo GCH, Zhang J. A Novel Molecular Ruler between Fluorescent Proteins Biophysical Journal. 108. DOI: 10.1016/J.Bpj.2014.11.1895  0.5
2014 Gorshkov K, Zhang J. Visualization of cyclic nucleotide dynamics in neurons. Frontiers in Cellular Neuroscience. 8: 395. PMID 25538560 DOI: 10.3389/Fncel.2014.00395  0.458
2014 Newman RH, Zhang J, Zhu H. Toward a systems-level view of dynamic phosphorylation networks. Frontiers in Genetics. 5: 263. PMID 25177341 DOI: 10.3389/Fgene.2014.00263  0.47
2014 Mehta S, Aye-Han NN, Ganesan A, Oldach L, Gorshkov K, Zhang J. Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin. Elife. 3: e03765. PMID 25056880 DOI: 10.7554/Elife.03765  0.434
2014 Kim TJ, Sun J, Lu S, Zhang J, Wang Y. The regulation of β-adrenergic receptor-mediated PKA activation by substrate stiffness via microtubule dynamics in human MSCs. Biomaterials. 35: 8348-56. PMID 24973298 DOI: 10.1016/J.Biomaterials.2014.06.018  0.417
2014 Fu Q, Kim S, Soto D, De Arcangelis V, DiPilato L, Liu S, Xu B, Shi Q, Zhang J, Xiang YK. A long lasting β1 adrenergic receptor stimulation of cAMP/protein kinase A (PKA) signal in cardiac myocytes. The Journal of Biological Chemistry. 289: 14771-81. PMID 24713698 DOI: 10.1074/Jbc.M113.542589  0.812
2014 Sample V, Mehta S, Zhang J. Genetically encoded molecular probes to visualize and perturb signaling dynamics in living biological systems. Journal of Cell Science. 127: 1151-60. PMID 24634506 DOI: 10.1242/Jcs.099994  0.806
2014 Haj Slimane Z, Bedioune I, Lechêne P, Varin A, Lefebvre F, Mateo P, Domergue-Dupont V, Dewenter M, Richter W, Conti M, El-Armouche A, Zhang J, Fischmeister R, Vandecasteele G. Control of cytoplasmic and nuclear protein kinase A by phosphodiesterases and phosphatases in cardiac myocytes. Cardiovascular Research. 102: 97-106. PMID 24550350 DOI: 10.1093/Cvr/Cvu029  0.425
2014 Oldach L, Zhang J. Genetically encoded fluorescent biosensors for live-cell visualization of protein phosphorylation Chemistry and Biology. 21: 186-197. PMID 24485761 DOI: 10.1016/J.Chembiol.2013.12.012  0.437
2014 Wang Y, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GC, Schendowich LP, Sukhu A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ. Isoform-selective disruption of AKAP-localized PKA using hydrocarbon stapled peptides. Acs Chemical Biology. 9: 635-42. PMID 24422448 DOI: 10.1021/Cb400900R  0.411
2014 Hu J, Rho HS, Newman RH, Zhang J, Zhu H, Qian J. PhosphoNetworks: a database for human phosphorylation networks. Bioinformatics (Oxford, England). 30: 141-2. PMID 24227675 DOI: 10.1093/Bioinformatics/Btt627  0.403
2014 Cazabat L, Ragazzon B, Varin A, Potier-Cartereau M, Vandier C, Vezzosi D, Risk-Rabin M, Guellich A, Schittl J, Lechêne P, Richter W, Nikolaev VO, Zhang J, Bertherat J, Vandecasteele G. Inactivation of the Carney complex gene 1 (PRKAR1A) alters spatiotemporal regulation of cAMP and cAMP-dependent protein kinase: a study using genetically encoded FRET-based reporters. Human Molecular Genetics. 23: 1163-74. PMID 24122441 DOI: 10.1093/Hmg/Ddt510  0.452
2014 Robinson KH, Yang JR, Zhang J. FRET and BRET-based biosensors in live cell compound screens. Methods in Molecular Biology (Clifton, N.J.). 1071: 217-25. PMID 24052392 DOI: 10.1007/978-1-62703-622-1_17  0.369
2014 Aye-Han NN, Zhang J. A multiparameter live cell imaging approach to monitor cyclic AMP and protein kinase A dynamics in parallel. Methods in Molecular Biology (Clifton, N.J.). 1071: 207-15. PMID 24052391 DOI: 10.1007/978-1-62703-622-1_16  0.437
2014 Aye-Han NN, Zhang J. A multiparameter live cell imaging approach to monitor cyclic AMP and protein kinase A dynamics in parallel. Methods in Molecular Biology (Clifton, N.J.). 1071: 207-15. PMID 24052391 DOI: 10.1007/978-1-62703-622-1_16  0.437
2014 Mehta S, Zhang J. Using a genetically encoded FRET-based reporter to visualize calcineurin phosphatase activity in living cells. Methods in Molecular Biology (Clifton, N.J.). 1071: 139-49. PMID 24052386 DOI: 10.1007/978-1-62703-622-1_11  0.451
2014 Newman RH, Zhang J. The design and application of genetically encodable biosensors based on fluorescent proteins. Methods in Molecular Biology (Clifton, N.J.). 1071: 1-16. PMID 24052376 DOI: 10.1007/978-1-62703-622-1_1  0.411
2014 Hu J, Rho HS, Newman RH, Hwang W, Neiswinger J, Zhu H, Zhang J, Qian J. Global analysis of phosphorylation networks in humans. Biochimica Et Biophysica Acta. 1844: 224-31. PMID 23524292 DOI: 10.1016/J.Bbapap.2013.03.009  0.438
2014 Mehta S, Aye-Han N, Ganesan A, Oldach L, Gorshkov K, Zhang J. Author response: Calmodulin-controlled spatial decoding of oscillatory Ca2+ signals by calcineurin Elife. DOI: 10.7554/Elife.03765.018  0.302
2014 Mo G, Zhang J. Mute-Kars: Silent Kinase Activity Reporters Useful for Co-Imaging Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.4443  0.441
2014 Ross BL, Zhang J. Superresolution Plasmalemmal Lipid Mapping Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.1756  0.365
2014 Zhang J. Probing Spatiotemporal Regulation of Signal Transduction in Living Cells Biophysical Journal. 106. DOI: 10.1016/J.Bpj.2013.11.080  0.542
2014 Hertel F, Zhang J. Monitoring of post-translational modification dynamics with genetically encoded fluorescent reporters Biopolymers. 101: 180-187. DOI: 10.1002/Bip.22254  0.446
2013 Mehta S, Zhang J. Using a kinase-inducible bimolecular switch to control enzyme activity in living cells. Current Protocols in Chemical Biology. 5: 227-37. PMID 24391085 DOI: 10.1002/9780470559277.Ch130090  0.439
2013 Woodard CL, Goodwin CR, Wan J, Xia S, Newman R, Hu J, Zhang J, Hayward SD, Qian J, Laterra J, Zhu H. Profiling the dynamics of a human phosphorylome reveals new components in HGF/c-Met signaling. Plos One. 8: e72671. PMID 24023761 DOI: 10.1371/Journal.Pone.0072671  0.477
2013 Zhang J, Gao Z, Ye J. Phosphorylation and degradation of S6K1 (p70S6K1) in response to persistent JNK1 Activation. Biochimica Et Biophysica Acta. 1832: 1980-8. PMID 23816567 DOI: 10.1016/j.bbadis.2013.06.013  0.369
2013 Burdyga A, Conant A, Haynes L, Zhang J, Jalink K, Sutton R, Neoptolemos J, Costello E, Tepikin A. cAMP inhibits migration, ruffling and paxillin accumulation in focal adhesions of pancreatic ductal adenocarcinoma cells: effects of PKA and EPAC. Biochimica Et Biophysica Acta. 1833: 2664-72. PMID 23797058 DOI: 10.1016/j.bbamcr.2013.06.011  0.32
2013 Nunes AR, Holmes AP, Sample V, Kumar P, Cann MJ, Monteiro EC, Zhang J, Gauda EB. Bicarbonate-sensitive soluble and transmembrane adenylyl cyclases in peripheral chemoreceptors. Respiratory Physiology & Neurobiology. 188: 83-93. PMID 23727159 DOI: 10.1016/J.Resp.2013.05.013  0.791
2013 Huang J, Yang JR, Zhang J, Yang J. Total synthesis and structure-activity relationship study of the potent cAMP signaling agonist (-)-alotaketal A. Organic & Biomolecular Chemistry. 11: 3212-22. PMID 23584129 DOI: 10.1039/C3Ob40120K  0.433
2013 Newman RH, Hu J, Rho HS, Xie Z, Woodard C, Neiswinger J, Cooper C, Shirley M, Clark HM, Hu S, Hwang W, Jeong JS, Wu G, Lin J, Gao X, ... ... Zhang J, et al. Construction of human activity-based phosphorylation networks. Molecular Systems Biology. 9: 655. PMID 23549483 DOI: 10.1038/Msb.2013.12  0.349
2013 Depry C, Mehta S, Zhang J. Multiplexed visualization of dynamic signaling networks using genetically encoded fluorescent protein-based biosensors Pflugers Archiv European Journal of Physiology. 465: 373-381. PMID 23138230 DOI: 10.1007/S00424-012-1175-Y  0.816
2013 Sample V, Ni Q, Mehta S, Inoue T, Zhang J. Controlling enzymatic action in living cells with a kinase-inducible bimolecular switch Acs Chemical Biology. 8: 116-121. PMID 23072367 DOI: 10.1021/Cb300393W  0.832
2013 Sample V, DiPilato LM, Yang JH, Ni Q, Saucerman JJ, Zhang J. Erratum: Corrigendum: Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP Nature Chemical Biology. 9: 406-406. DOI: 10.1038/Nchembio0613-406B  0.791
2012 Nunes AR, Sample V, Xiang YK, Monteiro EC, Gauda E, Zhang J. Effect of oxygen on phosphodiesterases (PDE) 3 and 4 isoforms and PKA activity in the superior cervical ganglia Advances in Experimental Medicine and Biology. 758: 287-294. PMID 23080174 DOI: 10.1007/978-94-007-4584-1_39  0.816
2012 Ghigo A, Perino A, Mehel H, Zahradníková A, Morello F, Leroy J, Nikolaev VO, Damilano F, Cimino J, De Luca E, Richter W, Westenbroek R, Catterall WA, Zhang J, Yan C, et al. Phosphoinositide 3-kinase γ protects against catecholamine-induced ventricular arrhythmia through protein kinase A-mediated regulation of distinct phosphodiesterases. Circulation. 126: 2073-83. PMID 23008439 DOI: 10.1161/Circulationaha.112.114074  0.468
2012 Dedecker P, Mo GC, Dertinger T, Zhang J. Widely accessible method for superresolution fluorescence imaging of living systems. Proceedings of the National Academy of Sciences of the United States of America. 109: 10909-14. PMID 22711840 DOI: 10.1073/Pnas.1204917109  0.36
2012 Ganesan A, Zhang J. How cells process information: quantification of spatiotemporal signaling dynamics. Protein Science : a Publication of the Protein Society. 21: 918-28. PMID 22573643 DOI: 10.1002/Pro.2089  0.423
2012 Huang J, Yang JR, Zhang J, Yang J. Total synthesis of the potent cAMP signaling agonist (-)-alotaketal A. Journal of the American Chemical Society. 134: 8806-9. PMID 22563931 DOI: 10.1021/Ja303529Z  0.372
2012 Ferrando IM, Chaerkady R, Zhong J, Molina H, Jacob HK, Herbst-Robinson K, Dancy BM, Katju V, Bose R, Zhang J, Pandey A, Cole PA. Identification of targets of c-Src tyrosine kinase by chemical complementation and phosphoproteomics. Molecular & Cellular Proteomics : McP. 11: 355-69. PMID 22499769 DOI: 10.1074/Mcp.M111.015750  0.448
2012 Sample V, DiPilato LM, Yang JH, Ni Q, Saucerman JJ, Zhang J. Regulation of nuclear PKA revealed by spatiotemporal manipulation of cyclic AMP. Nature Chemical Biology. 8: 375-82. PMID 22366721 DOI: 10.1038/Nchembio.799  0.823
2012 Aye-Han NN, Allen MD, Ni Q, Zhang J. Parallel tracking of cAMP and PKA signaling dynamics in living cells with FRET-based fluorescent biosensors. Molecular Biosystems. 8: 1435-40. PMID 22362165 DOI: 10.1039/C2Mb05514G  0.493
2012 Zhou X, Herbst-Robinson KJ, Zhang J. Visualizing dynamic activities of signaling enzymes using genetically encodable FRET-based biosensors: From designs to applications Methods in Enzymology. 504: 317-340. PMID 22264542 DOI: 10.1016/B978-0-12-391857-4.00016-1  0.519
2012 del Puerto A, Díaz-Hernández JI, Tapia M, Gomez-Villafuertes R, Benitez MJ, Zhang J, Miras-Portugal MT, Wandosell F, Díaz-Hernández M, Garrido JJ. Adenylate cyclase 5 coordinates the action of ADP, P2Y1, P2Y13 and ATP-gated P2X7 receptors on axonal elongation. Journal of Cell Science. 125: 176-88. PMID 22250198 DOI: 10.1242/Jcs.091736  0.317
2012 Slimane ZH, Zhang J, Richter W, Fischmeister R, Vandecasteele G. Spatiotemporal Regulation of cAMP-Dependent Protein Kinase (PKA) in Cardiac Myocytes Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.3637  0.391
2012 Ganesan A, Levchenko A, Zhang J. ERK-Mediated Decoding of Calcium Oscillations in Pancreatic Beta Cells Biophysical Journal. 102. DOI: 10.1016/J.Bpj.2011.11.2777  0.382
2011 Chan TO, Zhang J, Rodeck U, Pascal JM, Armen RS, Spring M, Dumitru CD, Myers V, Li X, Cheung JY, Feldman AM. Resistance of Akt kinases to dephosphorylation through ATP-dependent conformational plasticity Proceedings of the National Academy of Sciences of the United States of America. 108: E1120-E1127. PMID 22031698 DOI: 10.1073/Pnas.1109879108  0.314
2011 Chakir K, Depry C, Dimaano VL, Zhu WZ, Vanderheyden M, Bartunek J, Abraham TP, Tomaselli GF, Liu SB, Xiang YK, Zhang M, Takimoto E, Dulin N, Xiao RP, Zhang J, et al. Galphas-biased beta2-adrenergic receptor signaling from restoring synchronous contraction in the failing heart. Science Translational Medicine. 3: 100ra88. PMID 21918105 DOI: 10.1126/Scitranslmed.3001909  0.789
2011 Gao X, Lowry PR, Zhou X, Depry C, Wei Z, Wong GW, Zhang J. PI3K/Akt signaling requires spatial compartmentalization in plasma membrane microdomains. Proceedings of the National Academy of Sciences of the United States of America. 108: 14509-14. PMID 21873248 DOI: 10.1073/Pnas.1019386108  0.813
2011 Depry C, Zhang J. Using FRET-based reporters to visualize subcellular dynamics of protein kinase A activity Methods in Molecular Biology. 756: 285-294. PMID 21870233 DOI: 10.1007/978-1-61779-160-4_16  0.833
2011 Herbst KJ, Allen MD, Zhang J. Spatiotemporally regulated protein kinase a activity is a critical regulator of growth factor-stimulated extracellular signal-regulated kinase signaling in PC12 Cells Molecular and Cellular Biology. 31: 4063-4075. PMID 21807900 DOI: 10.1128/Mcb.05459-11  0.515
2011 Mehta S, Zhang J. Reporting from the field: Genetically encoded fluorescent reporters uncover signaling dynamics in living biological systems Annual Review of Biochemistry. 80: 375-401. PMID 21495849 DOI: 10.1146/Annurev-Biochem-060409-093259  0.42
2011 Newman RH, Fosbrink MD, Zhang J. Genetically encodable fluorescent biosensors for tracking signaling dynamics in living cells. Chemical Reviews. 111: 3614-66. PMID 21456512 DOI: 10.1021/Cr100002U  0.442
2011 Herbst KJ, Allen MD, Zhang J. Luminescent kinase activity biosensors based on a versatile bimolecular switch Journal of the American Chemical Society. 133: 5676-5679. PMID 21438554 DOI: 10.1021/Ja1117396  0.497
2011 Wan M, Li J, Herbst K, Zhang J, Yu B, Wu X, Qiu T, Lei W, Lindvall C, Williams BO, Ma H, Zhang F, Cao X. LRP6 mediates cAMP generation by G protein-coupled receptors through regulating the membrane targeting of Gα(s). Science Signaling. 4: ra15. PMID 21406690 DOI: 10.1126/Scisignal.2001464  0.395
2011 Herbst KJ, Coltharp C, Amzel LM, Zhang J. Direct activation of Epac by sulfonylurea is isoform selective Chemistry and Biology. 18: 243-251. PMID 21338921 DOI: 10.1016/J.Chembiol.2010.12.007  0.375
2011 Liu S, Zhang J, Xiang YK. FRET-based direct detection of dynamic protein kinase A activity on the sarcoplasmic reticulum in cardiomyocytes Biochemical and Biophysical Research Communications. 404: 581-586. PMID 21130738 DOI: 10.1016/J.Bbrc.2010.11.116  0.509
2011 Ni Q, Ganesan A, Aye-Han NN, Gao X, Allen MD, Levchenko A, Zhang J. Signaling diversity of PKA achieved via a Ca2+-cAMP-PKA oscillatory circuit. Nature Chemical Biology. 7: 34-40. PMID 21102470 DOI: 10.1038/Nchembio.478  0.495
2011 Depry C, Allen MD, Zhang J. Visualization of PKA activity in plasma membrane microdomains. Molecular Biosystems. 7: 52-8. PMID 20838685 DOI: 10.1039/C0Mb00079E  0.787
2011 Gao X, Zhang J. Akt signaling dynamics in plasma membrane microdomains visualized by FRET-based reporters. Communicative & Integrative Biology. 2: 32-4. PMID 19704863 DOI: 10.4161/cib.2.1.7420  0.315
2011 Ganesan A, Ni Q, Aye-Han N, Gao X, Allen MD, Levchenko A, Zhang J. PKA is a Control Node in a Calcium-Dependent Oscillatory Circuit in Pancreatic Beta Cells Biophysical Journal. 100. DOI: 10.1016/J.Bpj.2010.12.3023  0.445
2010 Gildea JJ, Shah I, Weiss R, Casscells ND, McGrath HE, Zhang J, Jones JE, Felder RA. HK-2 human renal proximal tubule cells as a model for G protein-coupled receptor kinase type 4-mediated dopamine 1 receptor uncoupling. Hypertension. 56: 505-11. PMID 20660820 DOI: 10.1161/Hypertensionaha.110.152256  0.311
2010 Depry C, Zhang J. Visualization of kinase activity with FRET-based activity biosensors Current Protocols in Molecular Biology / Edited by Frederick M. Ausubel ... [Et Al.]. Unit 18.15. PMID 20583095 DOI: 10.1002/0471142727.Mb1815S91  0.827
2010 Fosbrink M, Aye-Han NN, Cheong R, Levchenko A, Zhang J. Visualization of JNK activity dynamics with a genetically encoded fluorescent biosensor. Proceedings of the National Academy of Sciences of the United States of America. 107: 5459-64. PMID 20212108 DOI: 10.1073/Pnas.0909671107  0.501
2010 Gao X, Zhang J. FRET-based activity biosensors to probe compartmentalized signaling Chembiochem. 11: 147-151. PMID 20014085 DOI: 10.1002/Cbic.200900594  0.423
2010 DiPilato LM, Zhang J. Fluorescent protein-based biosensors: resolving spatiotemporal dynamics of signaling. Current Opinion in Chemical Biology. 14: 37-42. PMID 19910237 DOI: 10.1016/J.Cbpa.2009.10.012  0.819
2010 Ni Q, Zhang J. Dynamic Visualization of cellular signaling Advances in Biochemical Engineering/Biotechnology. 119: 79-97. PMID 19499207 DOI: 10.1007/10_2008_48  0.471
2010 Gildea JJ, Shah I, Weiss R, Casscells ND, McGrath HE, Zhang J, Felder RA. Erratum: HK-2 human renal proximal tubule cells as a model for G protein-coupled receptor kinase type 4-mediated dopamine 1 receptor uncoupling (Hypertension (2010) 56 (505-511)) Hypertension. 56. DOI: 10.1161/Hyp.0B013E3181F914Ee  0.324
2009 Sample V, Newman RH, Zhang J. The structure and function of fluorescent proteins. Chemical Society Reviews. 38: 2852-64. PMID 19771332 DOI: 10.1039/B913033K  0.789
2009 Gildea JJ, Israel JA, Johnson AK, Zhang J, Jose PA, Felder RA. Caveolin-1 and dopamine-mediated internalization of NaKATPase in human renal proximal tubule cells. Hypertension. 54: 1070-6. PMID 19752292 DOI: 10.1161/Hypertensionaha.109.134338  0.359
2009 Aye-Han NN, Ni Q, Zhang J. Fluorescent biosensors for real-time tracking of post-translational modification dynamics Current Opinion in Chemical Biology. 13: 392-397. PMID 19682946 DOI: 10.1016/J.Cbpa.2009.07.009  0.393
2009 Herbst KJ, Ni Q, Zhang J. Dynamic visualization of signal transduction in living cells: From second messengers to kinases Iubmb Life. 61: 902-908. PMID 19603514 DOI: 10.1002/Iub.232  0.499
2009 DiPilato LM, Zhang J. The role of membrane microdomains in shaping beta2-adrenergic receptor-mediated cAMP dynamics. Molecular Biosystems. 5: 832-7. PMID 19603118 DOI: 10.1039/B823243A  0.8
2009 Herbst KJ, Allen MD, Zhang J. The cAMP-dependent protein kinase inhibitor H-89 attenuates the bioluminescence signal produced by Renilla Luciferase. Plos One. 4: e5642. PMID 19461967 DOI: 10.1371/Journal.Pone.0005642  0.484
2009 Zhang J. The colorful journey of green fluorescent protein Acs Chemical Biology. 4: 85-88. PMID 19228068 DOI: 10.1021/Cb900027R  0.331
2009 Soto D, De Arcangelis V, Zhang J, Xiang Y. Dynamic protein kinase a activities induced by beta-adrenoceptors dictate signaling propagation for substrate phosphorylation and myocyte contraction. Circulation Research. 104: 770-9. PMID 19213958 DOI: 10.1161/Circresaha.108.187880  0.472
2009 Seong J, Lu S, Ouyang M, Huang H, Zhang J, Frame MC, Wang Y. Visualization of Src activity at different compartments of the plasma membrane by FRET imaging. Chemistry & Biology. 16: 48-57. PMID 19171305 DOI: 10.1016/J.Chembiol.2008.11.007  0.394
2009 Rahdar M, Inoue T, Meyer T, Zhang J, Vazquez F, Devreotes PN. A phosphorylation-dependent intramolecular interaction regulates the membrane association and activity of the tumor suppressor PTEN. Proceedings of the National Academy of Sciences of the United States of America. 106: 480-5. PMID 19114656 DOI: 10.1073/Pnas.0811212106  0.721
2008 Ananthanarayanan B, Ni Q, Zhang J. Chapter 2: Molecular sensors based on fluorescence resonance energy transfer to visualize cellular dynamics. Methods in Cell Biology. 89: 37-57. PMID 19118671 DOI: 10.1016/S0091-679X(08)00602-X  0.41
2008 Vincent P, Gervasi N, Zhang J. Real-time monitoring of cyclic nucleotide signaling in neurons using genetically encoded FRET probes. Brain Cell Biology. 36: 3-17. PMID 18941898 DOI: 10.1007/S11068-008-9035-6  0.609
2008 Allen MD, DiPilato LM, Ananthanarayanan B, Newman RH, Ni Q, Zhang J. Dynamic visualization of signaling activities in living cells. Science Signaling. 1: pt6. PMID 18799423 DOI: 10.1126/Scisignal.137Pt6  0.848
2008 Lim CJ, Kain KH, Tkachenko E, Goldfinger LE, Gutierrez E, Allen MD, Groisman A, Zhang J, Ginsberg MH. Integrin-mediated protein kinase A activation at the leading edge of migrating cells. Molecular Biology of the Cell. 19: 4930-41. PMID 18784251 DOI: 10.1091/Mbc.E08-06-0564  0.488
2008 Szewczuk LM, Tarrant MK, Sample V, Drury WJ, Zhang J, Cole PA. Analysis of serotonin N-acetyltransferase regulation in vitro and in live cells using protein semisynthesis. Biochemistry. 47: 10407-19. PMID 18771288 DOI: 10.1021/Bi801189D  0.821
2008 Lu S, Ouyang M, Seong J, Zhang J, Chien S, Wang Y. The spatiotemporal pattern of Src activation at lipid rafts revealed by diffusion-corrected FRET imaging. Plos Computational Biology. 4: e1000127. PMID 18711637 DOI: 10.1371/Journal.Pcbi.1000127  0.396
2008 Gao X, Zhang J. Spatiotemporal analysis of differential Akt regulation in plasma membrane microdomains Molecular Biology of the Cell. 19: 4366-4373. PMID 18701703 DOI: 10.1091/Mbc.E08-05-0449  0.459
2008 Newman RH, Zhang J. Visualization of phosphatase activity in living cells with a FRET-based calcineurin activity sensor Molecular Biosystems. 4: 496-501. PMID 18493642 DOI: 10.1039/B720034J  0.527
2008 Violin JD, DiPilato LM, Yildirim N, Elston TC, Zhang J, Lefkowitz RJ. beta2-adrenergic receptor signaling and desensitization elucidated by quantitative modeling of real time cAMP dynamics. The Journal of Biological Chemistry. 283: 2949-61. PMID 18045878 DOI: 10.1074/Jbc.M707009200  0.81
2008 Ni Q, Fosbrink M, Zhang J. Illuminating the phosphatidylinositol 3-kinase/Akt pathway Progress in Biomedical Optics and Imaging - Proceedings of Spie. 6868. DOI: 10.1117/12.765524  0.516
2007 Zhang J, Allen MD. FRET-based biosensors for protein kinases: illuminating the kinome. Molecular Biosystems. 3: 759-65. PMID 17940658 DOI: 10.1039/B706628G  0.516
2007 Ananthanarayanan B, Fosbrink M, Rahdar M, Zhang J. Live-cell molecular analysis of Akt activation reveals roles for activation loop phosphorylation. The Journal of Biological Chemistry. 282: 36634-41. PMID 17928291 DOI: 10.1074/Jbc.M706227200  0.758
2007 Sachs BD, Baillie GS, McCall JR, Passino MA, Schachtrup C, Wallace DA, Dunlop AJ, MacKenzie KF, Klussmann E, Lynch MJ, Sikorski SL, Nuriel T, Tsigelny I, Zhang J, Houslay MD, et al. p75 neurotrophin receptor regulates tissue fibrosis through inhibition of plasminogen activation via a PDE4/cAMP/PKA pathway. The Journal of Cell Biology. 177: 1119-32. PMID 17576803 DOI: 10.1083/Jcb.200701040  0.329
2007 Maresh J, Zhang J, Tzeng YL, Goodman NA, Lynn DG. Rational design of inhibitors of VirA-VirG two-component signal transduction. Bioorganic & Medicinal Chemistry Letters. 17: 3281-6. PMID 17470391 DOI: 10.1016/J.Bmcl.2007.04.018  0.348
2007 Gervasi N, Hepp R, Tricoire L, Zhang J, Lambolez B, Paupardin-Tritsch D, Vincent P. Dynamics of protein kinase A signaling at the membrane, in the cytosol, and in the nucleus of neurons in mouse brain slices. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 2744-50. PMID 17360896 DOI: 10.1523/Jneurosci.5352-06.2007  0.624
2006 Allen MD, DiPilato LM, Rahdar M, Ren YR, Chong C, Liu JO, Zhang J. Reading dynamic kinase activity in living cells for high-throughput screening. Acs Chemical Biology. 1: 371-6. PMID 17163774 DOI: 10.1021/Cb600202F  0.821
2006 Maresh J, Zhang J, Lynn DG. The innate immunity of maize and the dynamic chemical strategies regulating two-component signal transduction in Agrobacterium tumefaciens. Acs Chemical Biology. 1: 165-75. PMID 17163664 DOI: 10.1021/Cb600051W  0.3
2006 Dunn TA, Wang CT, Colicos MA, Zaccolo M, DiPilato LM, Zhang J, Tsien RY, Feller MB. Imaging of cAMP levels and protein kinase A activity reveals that retinal waves drive oscillations in second-messenger cascades. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 12807-15. PMID 17151284 DOI: 10.1523/Jneurosci.3238-06.2006  0.815
2006 DiPilato LM, Zhang J. FRETting mice shed light on cardiac adrenergic signaling. Circulation Research. 99: 1021-3. PMID 17095728 DOI: 10.1161/01.Res.0000250962.61995.Cf  0.827
2006 Ni Q, Titov DV, Zhang J. Analyzing protein kinase dynamics in living cells with FRET reporters. Methods (San Diego, Calif.). 40: 279-86. PMID 16908183 DOI: 10.1016/J.Ymeth.2006.06.013  0.515
2006 Saucerman JJ, Zhang J, Martin JC, Peng LX, Stenbit AE, Tsien RY, McCulloch AD. Systems analysis of PKA-mediated phosphorylation gradients in live cardiac myocytes. Proceedings of the National Academy of Sciences of the United States of America. 103: 12923-8. PMID 16905651 DOI: 10.1073/Pnas.0600137103  0.779
2006 Allen MD, Zhang J. Subcellular dynamics of protein kinase A activity visualized by FRET-based reporters. Biochemical and Biophysical Research Communications. 348: 716-21. PMID 16895723 DOI: 10.1016/J.Bbrc.2006.07.136  0.52
2006 Qiao Y, Molina H, Pandey A, Zhang J, Cole PA. Chemical rescue of a mutant enzyme in living cells. Science (New York, N.Y.). 311: 1293-7. PMID 16513984 DOI: 10.1126/Science.1122224  0.469
2005 Ananthanarayanan B, Ni Q, Zhang J. Signal propagation from membrane messengers to nuclear effectors revealed by reporters of phosphoinositide dynamics and Akt activity. Proceedings of the National Academy of Sciences of the United States of America. 102: 15081-6. PMID 16214892 DOI: 10.1073/Pnas.0502889102  0.471
2005 Zhang J, Hupfeld CJ, Taylor SS, Olefsky JM, Tsien RY. Insulin disrupts beta-adrenergic signalling to protein kinase A in adipocytes. Nature. 437: 569-73. PMID 16177793 DOI: 10.1038/Nature04140  0.606
2005 Kunkel MT, Ni Q, Tsien RY, Zhang J, Newton AC. Spatio-temporal dynamics of protein kinase B/Akt signaling revealed by a genetically encoded fluorescent reporter. The Journal of Biological Chemistry. 280: 5581-7. PMID 15583002 DOI: 10.1074/Jbc.M411534200  0.696
2004 DiPilato LM, Cheng X, Zhang J. Fluorescent indicators of cAMP and Epac activation reveal differential dynamics of cAMP signaling within discrete subcellular compartments. Proceedings of the National Academy of Sciences of the United States of America. 101: 16513-8. PMID 15545605 DOI: 10.1073/Pnas.0405973101  0.843
2003 Violin JD, Zhang J, Tsien RY, Newton AC. A genetically encoded fluorescent reporter reveals oscillatory phosphorylation by protein kinase C. The Journal of Cell Biology. 161: 899-909. PMID 12782683 DOI: 10.1083/Jcb.200302125  0.632
2003 Zhang J, Campbell RE, Ting AY, Tsien RY. Erratum: Creating New Fluorescent Probes For Cell Biology Nature Reviews Molecular Cell Biology. 4: 80-80. DOI: 10.1038/Nrm1031  0.725
2002 Zhang J, Campbell RE, Ting AY, Tsien RY. Creating new fluorescent probes for cell biology. Nature Reviews. Molecular Cell Biology. 3: 906-18. PMID 12461557 DOI: 10.1038/Nrm976  0.768
2001 Zhang J, Ma Y, Taylor SS, Tsien RY. Genetically encoded reporters of protein kinase A activity reveal impact of substrate tethering. Proceedings of the National Academy of Sciences of the United States of America. 98: 14997-5002. PMID 11752448 DOI: 10.1073/Pnas.211566798  0.668
2000 Campbell AM, Tok JB, Zhang J, Wang Y, Stein M, Lynn DG, Binns AN. Xenognosin sensing in virulence: is there a phenol receptor in Agrobacterium tumefaciens? Chemistry & Biology. 7: 65-76. PMID 10662683 DOI: 10.1016/S1074-5521(00)00065-X  0.364
Low-probability matches (unlikely to be authored by this person)
2021 Zhou X, Zhong Y, Zhang J. Regulation of nuclear mTORC1. Molecular & Cellular Oncology. 8: 1896348. PMID 34027037 DOI: 10.1080/23723556.2021.1896348  0.3
2020 Cui R, Jiang N, Zhang M, Du S, Ou H, Ge R, Ma D, Zhang J. AMOTL2 inhibits JUN Thr239 dephosphorylation by binding PPP2R2A to suppress the proliferation in non-small cell lung cancer cells. Biochimica Et Biophysica Acta. Molecular Cell Research. 118858. PMID 32950569 DOI: 10.1016/j.bbamcr.2020.118858  0.297
2023 Martinez JM, Shen A, Xu B, Jovanovic A, de Chabot J, Zhang J, Xiang YK. Arrestin-dependent nuclear export of phosphodiesterase 4D promotes GPCR-induced nuclear cAMP signaling required for learning and memory. Science Signaling. 16: eade3380. PMID 36976866 DOI: 10.1126/scisignal.ade3380  0.296
2012 Dancy BM, Crump NT, Peterson DJ, Mukherjee C, Bowers EM, Ahn YH, Yoshida M, Zhang J, Mahadevan LC, Meyers DJ, Boeke JD, Cole PA. Live-cell studies of p300/CBP histone acetyltransferase activity and inhibition. Chembiochem : a European Journal of Chemical Biology. 13: 2113-21. PMID 22961914 DOI: 10.1002/Cbic.201200381  0.295
2012 Dancy BM, Crump NT, Peterson DJ, Mukherjee C, Bowers EM, Ahn Y, Yoshida M, Zhang J, Mahadevan LC, Meyers DJ, Boeke JD, Cole PA. Cover Picture: Live-Cell Studies of p300/CBP Histone Acetyltransferase Activity and Inhibition (ChemBioChem 14/2012) Chembiochem. 13: 1973-1973. DOI: 10.1002/Cbic.201290057  0.294
2014 Xu F, Wang YL, Chang JJ, Du SC, Diao L, Jiang N, Wang HJ, Ma D, Zhang J. Mammalian sterile 20-like kinase 1/2 inhibits the Wnt/β-catenin signalling pathway by directly binding casein kinase 1ε. The Biochemical Journal. 458: 159-69. PMID 24180524 DOI: 10.1042/BJ20130986  0.293
2020 Tenner B, Getz M, Ross BL, Ohadi D, Mehta S, Rangamani P, Zhang J. Spatially Compartmentalized Phase Regulation in the Ca2+-cAMP-PKA-Oscillatory Circuit Biophysical Journal. 118: 175a. DOI: 10.1016/J.Bpj.2019.11.1073  0.293
2023 Frei MS, Zhang J. Chemigenetic kinase biosensors for multiplexed activity sensing and super-resolution imaging. Biophysical Journal. 122: 156a. PMID 36782727 DOI: 10.1016/j.bpj.2022.11.973  0.292
2008 Newman RH, Zhang J. Fucci: street lights on the road to mitosis. Chemistry & Biology. 15: 97-8. PMID 18291313 DOI: 10.1016/J.Chembiol.2008.02.003  0.29
2020 Zhou X, Zhong Y, Molinar-Inglis O, Kunkel MT, Chen M, Sun T, Zhang J, Shyy JY, Trejo J, Newton AC, Zhang J. Location-specific inhibition of Akt reveals regulation of mTORC1 activity in the nucleus. Nature Communications. 11: 6088. PMID 33257668 DOI: 10.1038/s41467-020-19937-w  0.29
2022 Zhong Y, Zhou X, Guan KL, Zhang J. Rheb regulates nuclear mTORC1 activity independent of farnesylation. Cell Chemical Biology. PMID 35294906 DOI: 10.1016/j.chembiol.2022.02.006  0.289
2024 Peng F, Liao M, Jin W, Liu W, Li Z, Fan Z, Zou L, Chen S, Zhu L, Zhao Q, Zhan G, Ouyang L, Peng C, Han B, Zhang J, et al. 2-APQC, a small-molecule activator of Sirtuin-3 (SIRT3), alleviates myocardial hypertrophy and fibrosis by regulating mitochondrial homeostasis. Signal Transduction and Targeted Therapy. 9: 133. PMID 38744811 DOI: 10.1038/s41392-024-01816-1  0.288
1991 Zhang J, Niu H, Jacob ST. E1BF is an essential RNA polymerase I transcription factor with an intrinsic protein kinase activity that can modulate rRNA gene transcription Proceedings of the National Academy of Sciences of the United States of America. 88: 8293-8296. PMID 1924288 DOI: 10.1073/Pnas.88.19.8293  0.284
2022 Zou L, Liao M, Zhen Y, Zhu S, Chen X, Zhang J, Hao Y, Liu B. Autophagy and beyond: Unraveling the complexity of UNC-51-like kinase 1 (ULK1) from biological functions to therapeutic implications. Acta Pharmaceutica Sinica. B. 12: 3743-3782. PMID 36213540 DOI: 10.1016/j.apsb.2022.06.004  0.281
2021 Su Q, Mehta S, Zhang J. Liquid-liquid phase separation: Orchestrating cell signaling through time and space. Molecular Cell. PMID 34619090 DOI: 10.1016/j.molcel.2021.09.010  0.28
2008 Allen MD, Zhang J. A tunable FRET circuit for engineering fluorescent biosensors. Angewandte Chemie (International Ed. in English). 47: 500-2. PMID 18058965 DOI: 10.1002/Anie.200703493  0.278
2024 Frei MS, Mehta S, Zhang J. Next-Generation Genetically Encoded Fluorescent Biosensors Illuminate Cell Signaling and Metabolism. Annual Review of Biophysics. PMID 38346245 DOI: 10.1146/annurev-biophys-030722-021359  0.277
2024 Zhou JQ, Li HJ, Zeng YH, Chen HH, Liang WY, Zhang J, Ding FP. [Baicalin induces ferroptosis in HepG2 cells by inhibiting ROS-mediated PI3K/Akt/FoxO3a signaling pathway]. Zhongguo Zhong Yao Za Zhi = Zhongguo Zhongyao Zazhi = China Journal of Chinese Materia Medica. 49: 1327-1334. PMID 38621980 DOI: 10.19540/j.cnki.cjcmm.20231010.403  0.276
2016 Shang F, Zhang J, Li Z, Zhang J, Yin Y, Wang Y, Marin TL, Gongol B, Xiao H, Zhang YY, Chen Z, Shyy JY, Lei T. Cardiovascular Protective Effect of Metformin and Telmisartan: Reduction of PARP1 Activity via the AMPK-PARP1 Cascade. Plos One. 11: e0151845. PMID 26986624 DOI: 10.1371/journal.pone.0151845  0.276
2010 Halm ST, Zhang J, Halm DR. beta-Adrenergic activation of electrogenic K+ and Cl- secretion in guinea pig distal colonic epithelium proceeds via separate cAMP signaling pathways. American Journal of Physiology. Gastrointestinal and Liver Physiology. 299: G81-95. PMID 20413718 DOI: 10.1152/ajpgi.00035.2010  0.274
2018 Hard R, Li N, He W, Ross B, Mo GCH, Peng Q, Stein RSL, Komives E, Wang Y, Zhang J, Wang W. Deciphering and engineering chromodomain-methyllysine peptide recognition. Science Advances. 4: eaau1447. PMID 30417094 DOI: 10.1126/Sciadv.Aau1447  0.273
2017 Nygren PJ, Mehta S, Schweppe DK, Langeberg LK, Whiting JL, Weisbrod CR, Bruce JE, Zhang J, Veesler D, Scott JD. Author response: Intrinsic disorder within AKAP79 fine-tunes anchored phosphatase activity toward substrates and drug sensitivity Elife. DOI: 10.7554/Elife.30872.022  0.273
2011 Gao Z, Zhang J, Kheterpal I, Kennedy N, Davis RJ, Ye J. Sirtuin 1 (SIRT1) protein degradation in response to persistent c-Jun N-terminal kinase 1 (JNK1) activation contributes to hepatic steatosis in obesity. The Journal of Biological Chemistry. 286: 22227-34. PMID 21540183 DOI: 10.1074/Jbc.M111.228874  0.272
2019 Li J, Zhang J, Tang W, Mizu RK, Kusumoto H, XiangWei W, Xu Y, Chen W, Amin JB, Perozo E, Hu C, Kannan V, Keller SR, Wilcox WR, Lemke JR, et al. De Novo GRIN Variants in NMDA Receptor M2 Channel Pore-Forming Loop Are Associated with Neurological Diseases. Human Mutation. PMID 31429998 DOI: 10.1002/Humu.23895  0.271
2021 Zhang JZ, Tenner B, Mehta S, Zhang J. Protocol for using fluorescent sensors targeted to endogenous proteins (FluoSTEPs) to measure microdomain-specific signaling events. Star Protocols. 2: 100693. PMID 34467224 DOI: 10.1016/j.xpro.2021.100693  0.271
2018 Zhang L, Ouyang L, Guo Y, Zhang J, Liu B. UNC-51-like kinase 1: From an autophagic initiator to multi-functional drug target. Journal of Medicinal Chemistry. PMID 29509411 DOI: 10.1021/acs.jmedchem.7b01684  0.271
2004 Valencia JV, Mone M, Zhang J, Weetall M, Buxton FP, Hughes TE. Divergent pathways of gene expression are activated by the RAGE ligands S100b and AGE-BSA. Diabetes. 53: 743-51. PMID 14988260 DOI: 10.2337/Diabetes.53.3.743  0.271
2005 Sumpio BE, Yun S, Cordova AC, Haga M, Zhang J, Koh Y, Madri JA. MAPKs (ERK1/2, p38) and AKT can be phosphorylated by shear stress independently of platelet endothelial cell adhesion molecule-1 (CD31) in vascular endothelial cells. The Journal of Biological Chemistry. 280: 11185-91. PMID 15668248 DOI: 10.1074/Jbc.M414631200  0.266
2023 Beeraka NM, Zhang J, Mandal S, Vikram P R H, Liu J, B M N, Zhao D, Vishwanath P, B M G, Fan R. Screening fructosamine-3-kinase (FN3K) inhibitors, a deglycating enzyme of oncogenic Nrf2: Human FN3K homology modelling, docking and molecular dynamics simulations. Plos One. 18: e0283705. PMID 37910519 DOI: 10.1371/journal.pone.0283705  0.264
2024 Lv Y, Mi P, Babon JJ, Fan G, Qi J, Cao L, Lang J, Zhang J, Wang F, Kobe B. Small molecule drug discovery targeting the JAK-STAT pathway. Pharmacological Research. 107217. PMID 38777110 DOI: 10.1016/j.phrs.2024.107217  0.261
2015 Wang WJ, Mou K, Wu XF, Zhang JZ, Ren G, Qi JD, Xu YF, Yao X. Grb2-associated binder 2 silencing impairs growth and migration of H1975 cells via modulation of PI3K-Akt signaling. International Journal of Clinical and Experimental Pathology. 8: 10575-84. PMID 26617767  0.261
2008 Newman RH, Zhang J. Small molecules and chemical tools at the interface Nature Chemical Biology. 4: 382-386. PMID 18560425 DOI: 10.1038/Nchembio0708-382  0.261
2017 Wu W, Zhang J, Zhao C, Sun Y, Wei-Jun P, Yang G. CTRP6 regulates porcine adipocyte proliferation and differentiation by the AdipoR1/MAPK signaling pathway. Journal of Agricultural and Food Chemistry. PMID 28535682 DOI: 10.1021/acs.jafc.7b00594  0.26
2021 Lin W, Mo GCH, Mehta S, Zhang J. DrFLINC Contextualizes Super-resolution Activity Imaging. Journal of the American Chemical Society. PMID 34516108 DOI: 10.1021/jacs.1c05530  0.259
2012 Dedecker P, Duwé S, Neely RK, Zhang J. Localizer: Fast, accurate, open-source, and modular software package for superresolution microscopy Journal of Biomedical Optics. 17. PMID 23208219 DOI: 10.1117/1.Jbo.17.12.126008  0.258
2020 Li S, Yin Y, Yao L, Lin Z, Sun S, Zhang J, Li X. TNF‑α treatment increases DKK1 protein levels in primary osteoblasts via upregulation of DKK1 mRNA levels and downregulation of miR‑335‑5p. Molecular Medicine Reports. PMID 32468044 DOI: 10.3892/mmr.2020.11152  0.258
2018 Xu Y, Dong B, Wang J, Zhang J, Xue W, Huang Y. Sphingosine kinase 1 overexpression contributes to sunitinib resistance in clear cell renal cell carcinoma. Oncoimmunology. 7: e1502130. PMID 30524898 DOI: 10.1080/2162402X.2018.1502130  0.257
2019 Liu F, Li N, Liu Y, Zhang J, Zhang J, Wang Z. Homeodomain interacting protein kinase-2 phosphorylates FOXM1 and promotes FOXM1-mediated tumor growth in renal cell carcinoma. Journal of Cellular Biochemistry. PMID 30609136 DOI: 10.1002/jcb.28323  0.254
2002 Zhou J, Zhang J, Lichtenheld MG, Meadows GG. A role for NF-kappa B activation in perforin expression of NK cells upon IL-2 receptor signaling. Journal of Immunology (Baltimore, Md. : 1950). 169: 1319-25. PMID 12133954 DOI: 10.4049/Jimmunol.169.3.1319  0.253
2012 Chen X, Zhang J, Zhang M, Liu S, Yan W, Jung J, Chen X. Serine 123 phosphorylation modulates p21 protein stability and activity by suppressing ubiquitin-independent proteasomal degradation. The Journal of Biological Chemistry. 287: 34410-8. PMID 22908227 DOI: 10.1074/Jbc.M112.384990  0.253
2024 Aljagthmi AA, Hira A, Zhang J, Cooke M, Kazanietz MG, Kadakia MP. ∆Np63α inhibits Rac1 activation and cancer cell invasion through suppression of PREX1. Cell Death Discovery. 10: 13. PMID 38191532 DOI: 10.1038/s41420-023-01789-0  0.252
2017 Zhang J, Zhang X, Liu Y, Su Z, Dawar FU, Dan H, He Y, Gui JF, Mei J. Leucine mediates autophagosome-lysosome fusion and improves sperm motility by activating the PI3K/Akt pathway. Oncotarget. 8: 111807-111818. PMID 29340093 DOI: 10.18632/oncotarget.22910  0.249
2022 Xue J, Fu Y, Fan S, Cao X, Huang W, Zhang J, Zhao Y, Chen F. Branched immunochip-integrated pairwise barcoding amplification exploring the spatial proximity of two post-translational modifications in distinct cell subpopulations. Chemical Communications (Cambridge, England). PMID 35983894 DOI: 10.1039/d2cc03833a  0.246
2023 Gao W, Zhang J, Zhang Y, Huang Y, Wang C, Liang Q, Yu Z, Fan R, Tang L, Fan Z. CoMFA Directed Molecular Design for Significantly Improving Fungicidal Activity of Novel [1,2,4]-Triazolo-[3,4-][1,3,4]-thiadizoles. Journal of Agricultural and Food Chemistry. PMID 37750514 DOI: 10.1021/acs.jafc.3c02444  0.245
2012 Wang X, Zhang J, Yuan M, Ehrhardt DW, Wang Z, Mao T. Arabidopsis microtubule destabilizing protein40 is involved in brassinosteroid regulation of hypocotyl elongation. The Plant Cell. 24: 4012-25. PMID 23115248 DOI: 10.1105/Tpc.112.103838  0.244
2021 Shi K, Zhang JZ, Yang L, Li NN, Yue Y, Du XH, Zhang XZ, Lu YC, Guo D. Protein deubiquitylase USP3 stabilizes Aurora A to promote proliferation and metastasis of esophageal squamous cell carcinoma. Bmc Cancer. 21: 1196. PMID 34758762 DOI: 10.1186/s12885-021-08934-x  0.243
2022 Yang LK, Zhang J, Liu D, Han TY, Qin QS, Wang AQ, Dong B. Ancestral glycoprotein hormone and its cognate receptor present in primitive chordate ascidian: Molecular identification and functional characterization. International Journal of Biological Macromolecules. 229: 401-412. PMID 36592853 DOI: 10.1016/j.ijbiomac.2022.12.297  0.243
2014 Mehta S, Zhang J. Using a genetically encoded FRET-based reporter to visualize calcineurin phosphatase activity in living cells Methods in Molecular Biology. 1071: 139-149. DOI: 10.1007/978-1-62703-622-1_11  0.243
2021 Han Y, Zhang J, Pang Y, Wang Y, Zhang X, Zhang H. The role of Src homology region 2 domain-containing phosphatase-1 hypermethylation in the classification of patients with myelodysplastic syndromes and its association with signal transducer and activator of transcription 3 phosphorylation in skm-1 cells. The Journal of International Medical Research. 49: 300060521999550. PMID 33736531 DOI: 10.1177/0300060521999550  0.242
2018 Zhang J, Yang C, Zhou F, Chen X. PDK1 inhibitor GSK2334470 synergizes with proteasome inhibitor MG‑132 in multiple myeloma cells by inhibiting full AKT activity and increasing nuclear accumulation of the PTEN protein. Oncology Reports. PMID 29658600 DOI: 10.3892/or.2018.6369  0.24
2018 Fry AE, Fawcett KA, Zelnik N, Yuan H, Thompson BAN, Shemer-Meiri L, Cushion TD, Mugalaasi H, Sims D, Stoodley N, Chung SK, Rees MI, Patel CV, Brueton LA, Layet V, ... ... Zhang J, et al. De novo mutations in GRIN1 cause extensive bilateral polymicrogyria. Brain : a Journal of Neurology. PMID 29365063 DOI: 10.1093/Brain/Awx358  0.24
2013 Wang ZY, Shi Q, Wang SB, Tian C, Xu Y, Guo Y, Chen C, Zhang J, Dong XP. Co-expressions of casein kinase 2 (CK2) subunits restore the down-regulation of tubulin levels and disruption of microtubule structures caused by PrP mutants. Journal of Molecular Neuroscience : Mn. 50: 14-22. PMID 22752506 DOI: 10.1007/s12031-012-9845-y  0.24
2012 Zhang J, Zhou J, Ren X, Diao Y, Li H, Jiang H, Ding K, Pei D. A new diaryl urea compound, D181, induces cell cycle arrest in the G1 and M phases by targeting receptor tyrosine kinases and the microtubule skeleton. Investigational New Drugs. 30: 490-507. PMID 21080210 DOI: 10.1007/S10637-010-9577-1  0.239
2013 Shi Q, Jing YY, Wang SB, Chen C, Sun H, Xu Y, Gao C, Zhang J, Tian C, Guo Y, Ren K, Dong XP. PrP octarepeats region determined the interaction with caveolin-1 and phosphorylation of caveolin-1 and Fyn. Medical Microbiology and Immunology. 202: 215-27. PMID 23283514 DOI: 10.1007/s00430-012-0284-8  0.237
2021 Yang X, Liu J, Zhang J, Shen Y, Qi Q, Bao X, Hou J. Quorum sensing-mediated protein degradation for dynamic metabolic pathway control in Saccharomyces cerevisiae. Metabolic Engineering. PMID 33545357 DOI: 10.1016/j.ymben.2021.01.010  0.237
2022 Zhu L, Zhao H, Wang Y, Yu C, Liu J, Li L, Li Z, Zhang J, Dai H, Wang J, Zhu L. Solubilization, purification, and ligand binding characterization of G protein-coupled receptor SMO in native membrane bilayer using styrene maleic acid copolymer. Peerj. 10: e13381. PMID 35529497 DOI: 10.7717/peerj.13381  0.236
2018 Zhang Y, Feng X, Sun W, Zhang J, Chen X. Serine-195 phosphorylation in the RNA-binding protein Rbm38 increases p63 expression by modulating Rbm38's interaction with the Ago2-miR203 complex. The Journal of Biological Chemistry. PMID 30567739 DOI: 10.1074/Jbc.Ra118.005779  0.236
2016 Zhang L, Wei J, Ren L, Zhang J, Yang M, Jing L, Wang J, Sun Z, Zhou X. Endosulfan inducing apoptosis and necroptosis through activation RIPK signaling pathway in human umbilical vascular endothelial cells. Environmental Science and Pollution Research International. PMID 27709431 DOI: 10.1007/s11356-016-7652-7  0.235
2014 Wang Y, Ho TG, Bertinetti D, Neddermann M, Franz E, Mo GCH, Schendowich LP, Sukhu A, Spelts RC, Zhang J, Herberg FW, Kennedy EJ. Correction to Isoform-Selective Disruption of AKAP-Localized PKA Using Hydrocarbon Stapled Peptides Acs Chemical Biology. 9: 1386-1386. DOI: 10.1021/Cb500329Z  0.233
2021 Cheng Y, Lou JX, Liu CC, Liu YY, Chen XN, Liang XD, Zhang J, Yang Q, Go YY, Zhou B. Microfilaments and microtubules alternately coordinate the multi-step endosomal trafficking of Classical Swine Fever Virus. Journal of Virology. PMID 33627389 DOI: 10.1128/JVI.02436-20  0.232
2023 Zhu W, Li W, Jiang J, Wang D, Mao X, Zhang J, Zhang X, Chang J, Yao P, Yang X, Da Costa C, Zhang Y, Yu J, Li H, Li S, et al. Chronic salmon calcitonin exerts an antidepressant effect modulating the p38 MAPK signaling pathway. Frontiers in Molecular Neuroscience. 16: 1071327. PMID 36969556 DOI: 10.3389/fnmol.2023.1071327  0.232
2024 Li H, Zhang J, Wang Z, Shi P, Shi C. Genetically encoded site-specific F unnatural amino acid incorporation in V. natriegens for in-cell NMR analysis. Protein Expression and Purification. 106461. PMID 38460621 DOI: 10.1016/j.pep.2024.106461  0.231
2005 Hammond-McKibben D, Saulnier M, Zhang J, Risher N, Lake P, Weetall M. Immunologic pathways in a quantitative model of immunosuppression based on rejection of an allogeneic or xenogeneic tumor graft. Transplantation. 79: 889-896. PMID 15849540 DOI: 10.1097/01.Tp.0000157361.50830.22  0.231
2015 Weng HJ, Patel KN, Jeske NA, Bierbower SM, Zou W, Tiwari V, Zheng Q, Tang Z, Mo GC, Wang Y, Geng Y, Zhang J, Guan Y, Akopian AN, Dong X. Tmem100 Is a Regulator of TRPA1-TRPV1 Complex and Contributes to Persistent Pain. Neuron. 85: 833-46. PMID 25640077 DOI: 10.1016/J.Neuron.2014.12.065  0.23
2019 Stacy AJ, Zhang J, Craig MP, Hira A, Dole N, Kadakia MP. TIP60 upregulates ΔNp63α to promote cellular proliferation. The Journal of Biological Chemistry. PMID 31601649 DOI: 10.1074/jbc.RA119.010388  0.23
2024 Mo GCH, Posner C, Rodriguez EA, Sun T, Zhang J. Author Correction: A rationally enhanced red fluorescent protein expands the utility of FRET biosensors. Nature Communications. 15: 771. PMID 38278819 DOI: 10.1038/s41467-024-45330-y  0.23
2008 Zhang J, Gao Z, Yin J, Quon MJ, Ye J. S6K directly phosphorylates IRS-1 on Ser-270 to promote insulin resistance in response to TNF-α signaling through IKK2 Journal of Biological Chemistry. 283: 35375-35382. PMID 18952604 DOI: 10.1074/jbc.M806480200  0.229
2019 Gong D, Zhang J, Chen Y, Xu Y, Ma J, Hu G, Huang Y, Zheng J, Zhai W, Xue W. The mA-suppressed P2RX6 activation promotes renal cancer cells migration and invasion through ATP-induced Ca influx modulating ERK1/2 phosphorylation and MMP9 signaling pathway. Journal of Experimental & Clinical Cancer Research : Cr. 38: 233. PMID 31159832 DOI: 10.1186/s13046-019-1223-y  0.229
2003 Chibber R, Ben-Mahmud BM, Mann GE, Zhang JJ, Kohner EM. Protein kinase C beta2-dependent phosphorylation of core 2 GlcNAc-T promotes leukocyte-endothelial cell adhesion: a mechanism underlying capillary occlusion in diabetic retinopathy. Diabetes. 52: 1519-27. PMID 12765965 DOI: 10.2337/Diabetes.52.6.1519  0.227
2019 An J, Li G, Zhang J, Zhou H, Jiang J, Wang X, Feng X, Wang S. GNAS knockdown suppresses osteogenic differentiation of mesenchymal stem cells via activation of Hippo signaling pathway. Journal of Cellular Physiology. PMID 31148202 DOI: 10.1002/jcp.28796  0.226
2018 Jones MR, Dilai S, Lingampally A, Chao CM, Danopoulos S, Carraro G, Mukhametshina R, Wilhelm J, Baumgart-Vogt E, Al Alam D, Chen C, Minoo P, Zhang JS, Bellusci S. A Comprehensive Analysis of Fibroblast Growth Factor Receptor 2b Signaling on Epithelial Tip Progenitor Cells During Early Mouse Lung Branching Morphogenesis. Frontiers in Genetics. 9: 746. PMID 30728831 DOI: 10.3389/Fgene.2018.00746  0.226
2023 Wu W, Yin Y, Huang J, Yang R, Li Q, Pan J, Zhang J. CRISPR/Cas9-meditated gene knockout in pigs proves that LGALS12 deficiency suppresses the proliferation and differentiation of porcine adipocytes. Biochimica Et Biophysica Acta. Molecular and Cell Biology of Lipids. 159424. PMID 37956708 DOI: 10.1016/j.bbalip.2023.159424  0.225
2018 Chen W, Yan Z, Li S, Huang N, Huang X, Zhang J, Zhong S. RNAs as Proximity-Labeling Media for Identifying Nuclear Speckle Positions Relative to the Genome. Iscience. 4: 204-215. PMID 30240742 DOI: 10.1016/J.Isci.2018.06.005  0.225
2014 Rask-Andersen M, Zhang J, Fabbro D, Schiöth HB. Advances in kinase targeting: current clinical use and clinical trials. Trends in Pharmacological Sciences. 35: 604-20. PMID 25312588 DOI: 10.1016/j.tips.2014.09.007  0.225
2016 Zhang L, Wei J, Ren L, Zhang J, Wang J, Jing L, Yang M, Yu Y, Sun Z, Zhou X. Endosulfan induces autophagy and endothelial dysfunction via the AMPK/mTOR signaling pathway triggered by oxidative stress. Environmental Pollution (Barking, Essex : 1987). PMID 27814983 DOI: 10.1016/j.envpol.2016.10.067  0.224
2016 Ch Mo G, Zhang J. Revealing a Heterodimeric Interface between the Members of Two Unrelated Fluorescent Protein Lineages Biophysical Journal. 110: 222a-223a. DOI: 10.1016/j.bpj.2015.11.1232  0.224
2013 Chen H, Zhang W, Sun X, Yoshimoto M, Chen Z, Zhu W, Liu J, Shen Y, Yong W, Li D, Zhang J, Lin Y, Li B, VanDusen NJ, Snider P, et al. Fkbp1a controls ventricular myocardium trabeculation and compaction by regulating endocardial Notch1 activity. Development (Cambridge, England). 140: 1946-57. PMID 23571217 DOI: 10.1242/Dev.089920  0.224
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2017 Zhang J, Corciulo C, Liu H, Wilder T, Ito M, Cronstein B. Adenosine A2a Receptor Blockade Diminishes Wnt/β-Catenin Signaling in a Murine Model of Bleomycin-Induced Dermal Fibrosis. The American Journal of Pathology. PMID 28667836 DOI: 10.1016/J.Ajpath.2017.05.005  0.187
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2015 Zhang Y, Liu Y, Zhang J. Saturated hydrogen saline attenuates endotoxin-induced lung dysfunction. The Journal of Surgical Research. 198: 41-9. PMID 26004495 DOI: 10.1016/j.jss.2015.04.055  0.184
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2016 Zhang J, Ratanasirintrawoot S, Chandrasekaran S, Wu Z, Ficarro SB, Yu C, Ross CA, Cacchiarelli D, Xia Q, Seligson M, Shinoda G, Xie W, Cahan P, Wang L, Ng SC, et al. LIN28 Regulates Stem Cell Metabolism and Conversion to Primed Pluripotency. Cell Stem Cell. PMID 27320042 DOI: 10.1016/J.Stem.2016.05.009  0.184
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2023 Xue D, Lu S, Zhang H, Zhang L, Dai Z, Kaufman DS, Zhang J. Induced pluripotent stem cell-derived engineered T cells, natural killer cells, macrophages, and dendritic cells in immunotherapy. Trends in Biotechnology. PMID 36858941 DOI: 10.1016/j.tibtech.2023.02.003  0.184
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2022 Wang L, Shan T, Pu L, Zhang J, Hu R, Yang Y, Yang J, Zhao Y. Glucometer-based electrochemical biosensor for determination of microRNA (let-7a) using magnetic-assisted extraction and supersandwich signal amplification. Mikrochimica Acta. 189: 444. PMID 36367605 DOI: 10.1007/s00604-022-05544-7  0.183
2020 Xia T, Zhang J, Zhou C, Li Y, Duan W, Zhang B, Wang M, Fang J. 20(S)-Ginsenoside Rh2 displays efficacy against T-cell acute lymphoblastic leukemia through the PI3K/Akt/mTOR signal pathway. Journal of Ginseng Research. 44: 725-737. PMID 32913402 DOI: 10.1016/j.jgr.2019.07.003  0.183
2021 Zhang D, Sun L, Zhang J. TMED3 exerts a protumor function in non-small cell lung cancer by enhancing the Wnt/β-catenin pathway via regulation of AKT. Toxicology and Applied Pharmacology. 115793. PMID 34758370 DOI: 10.1016/j.taap.2021.115793  0.183
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2023 Zhang J, Huang N, Li H, Cheng B, Zhou X, Wang C. Interaction between biochar-dissolved organic matter and chlorophenols during biochar adsorption. Environmental Science and Pollution Research International. PMID 36609760 DOI: 10.1007/s11356-022-25083-1  0.183
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2002 Jin J, Quinton TM, Zhang J, Rittenhouse SE, Kunapuli SP. Adenosine diphosphate (ADP)-induced thromboxane A(2) generation in human platelets requires coordinated signaling through integrin alpha(IIb)beta(3) and ADP receptors. Blood. 99: 193-8. PMID 11756171 DOI: 10.1182/Blood.V99.1.193  0.181
2011 Zhang J, Chen X. Novel role of Wip1 in p53-mediated cell homeostasis under non-stress conditions. Cell Cycle (Georgetown, Tex.). 10: 3235. PMID 21946519 DOI: 10.4161/Cc.10.19.17128  0.181
2018 Qiu R, Luo G, Li X, Zheng F, Li H, Zhang J, You Q, Xiang H. Lipid accumulation inhibitory activities of novel isoxazole-based chenodeoxycholic acids: Design, synthesis and preliminary mechanism study. Bioorganic & Medicinal Chemistry Letters. PMID 30031618 DOI: 10.1016/j.bmcl.2018.07.026  0.181
2015 Yu L, Tu Q, Han Q, Zhang L, Sui L, Zheng L, Meng S, Tang Y, Xuan D, Zhang J, Murray D, Shen Q, Cheng J, Kim SH, Dong LQ, et al. Adiponectin regulates bone marrow mesenchymal stem cell niche through a unique signal transduction pathway: an approach for treating bone disease in diabetes. Stem Cells (Dayton, Ohio). 33: 240-52. PMID 25187480 DOI: 10.1002/Stem.1844  0.181
2015 Wang H, Zhang Y, Lu Y, Song J, Huang M, Zhang J, Huang Y. The role of stearoyl-coenzyme A desaturase 1 in clear cell renal cell carcinoma. Tumour Biology : the Journal of the International Society For Oncodevelopmental Biology and Medicine. PMID 26224474 DOI: 10.1007/s13277-015-3451-x  0.181
2013 Zhang J. New insights into the contribution of arterial NCX to the regulation of myogenic tone and blood pressure. Advances in Experimental Medicine and Biology. 961: 329-43. PMID 23224892 DOI: 10.1007/978-1-4614-4756-6_28  0.181
2021 Guan H, Zhang J, Luan J, Xu H, Huang Z, Yu Q, Gou X, Xu L. Secreted Frizzled Related Proteins in Cardiovascular and Metabolic Diseases. Frontiers in Endocrinology. 12: 712217. PMID 34489867 DOI: 10.3389/fendo.2021.712217  0.18
2020 Chen F, Xue J, Zhang J, Bai M, Yu X, Fan C, Zhao Y. Differentiated Visualization of Single-cell 5-Hydroxymethylpyrimidines with Microfluidic Hydrogel Encoding. Journal of the American Chemical Society. PMID 31986025 DOI: 10.1021/Jacs.9B11393  0.18
2018 Zhang J, Li Y, Liu B, Wang L, Zhang L, Hu J, Chen J, Zheng H, Lu M. Characterization of the Populus Rab family genes and the function of PtRabE1b in salt tolerance. Bmc Plant Biology. 18: 124. PMID 29914373 DOI: 10.1186/s12870-018-1342-1  0.179
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2023 Xin FF, Xu JJ, Zhang J, Wang AJ, Xue Y, Mei LP, Song P, Feng JJ. Nanozyme-assisted ratiometric photoelectrochemical aptasensor over CuO nanocubes mediated photocurrent-polarity-switching based on S-scheme FeCdS@FeInS heterostructure. Biosensors & Bioelectronics. 237: 115442. PMID 37321042 DOI: 10.1016/j.bios.2023.115442  0.177
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2022 Zhang J, Kong X, Sun W, Wang L, Shen T, Chen M, Chen X. The RNA-binding protein RBM24 regulates lipid metabolism and SLC7A11 mRNA stability to modulate ferroptosis and inflammatory response. Frontiers in Cell and Developmental Biology. 10: 1008576. PMID 36478739 DOI: 10.3389/fcell.2022.1008576  0.175
2017 Zhang J, Shan Y, Li Y, Luo X, Shi H. Palmitate impairs angiogenesis via suppression of cathepsin activity. Molecular Medicine Reports. PMID 28440480 DOI: 10.3892/mmr.2017.6463  0.175
2006 Han J, Zhang J, Yao H, Wang X, Li F, Chen L, Gao C, Gao J, Nie K, Zhou W, Dong X. Study on interaction between microtubule associated protein tau and prion protein. Science in China. Series C, Life Sciences / Chinese Academy of Sciences. 49: 473-9. PMID 17172055 DOI: 10.1007/S11427-006-2019-9  0.174
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2015 Fu L, Zhang S, Zhang L, Tong X, Zhang J, Zhang Y, Ouyang L, Liu B, Huang J. Systems biology network-based discovery of a small molecule activator BL-AD008 targeting AMPK/ZIPK and inducing apoptosis in cervical cancer. Oncotarget. 6: 8071-88. PMID 25797270 DOI: 10.18632/ONCOTARGET.3513  0.174
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2007 Zhang J, Chen X. DeltaNp73 modulates nerve growth factor-mediated neuronal differentiation through repression of TrkA. Molecular and Cellular Biology. 27: 3868-80. PMID 17353261 DOI: 10.1128/Mcb.02112-06  0.174
2014 Qu ZS, Li L, Sun XJ, Zhao YW, Zhang J, Geng Z, Fu JL, Ren QG. Glycogen synthase kinase-3 regulates production of amyloid-β peptides and tau phosphorylation in diabetic rat brain. Thescientificworldjournal. 2014: 878123. PMID 24983010 DOI: 10.1155/2014/878123  0.174
2022 Zhou X, Yang Y, Xu Q, Zhou H, Zhong F, Deng J, Zhang J, Li J. Crystal structures of the catalytic domain of human PARP15 in complex with small molecule inhibitors. Biochemical and Biophysical Research Communications. 622: 93-100. PMID 35843099 DOI: 10.1016/j.bbrc.2022.06.070  0.173
2021 Sun Z, Yu H, Zhao J, Tan T, Pan H, Zhu Y, Chen L, Zhang C, Zhang L, Lei A, Xu Y, Bi X, Huang X, Gao B, Wang L, ... ... Zhang J, et al. LIN28 coordinately promotes nucleolar/ribosomal functions and represses the 2C-like transcriptional program in pluripotent stem cells. Protein & Cell. PMID 34331666 DOI: 10.1007/s13238-021-00864-5  0.173
2022 Gabriel NN, Balaji K, Jayachandran K, Inkman M, Zhang J, Dahiya S, Goldstein M. Loss of H3K27 trimethylation promotes radiotherapy resistance in medulloblastoma and induces an actionable vulnerability to BET inhibition. Cancer Research. PMID 35315927 DOI: 10.1158/0008-5472.CAN-21-0871  0.173
2019 Yin Y, Hao H, Xu X, Shen L, Wu W, Zhang J, Li Q. Generation of an MC3R knock-out pig by CRSPR/Cas9 combined with somatic cell nuclear transfer (SCNT) technology. Lipids in Health and Disease. 18: 122. PMID 31138220 DOI: 10.1186/s12944-019-1073-9  0.173
2002 Lacorazza HD, Miyazaki Y, Di Cristofano A, Deblasio A, Hedvat C, Zhang J, Cordon-Cardo C, Mao S, Pandolfi PP, Nimer SD. The ETS protein MEF plays a critical role in perforin gene expression and the development of natural killer and NK-T cells. Immunity. 17: 437-49. PMID 12387738 DOI: 10.1016/s1074-7613(02)00422-3  0.173
2022 Weeks R, Zhou X, Yuan TL, Zhang J. Fluorescent Biosensor for Measuring Ras Activity in Living Cells. Journal of the American Chemical Society. PMID 36122391 DOI: 10.1021/jacs.2c05203  0.172
2002 Burns CE, DeBlasio T, Zhou Y, Zhang J, Zon L, Nimer SD. Isolation and characterization of runxa and runxb, zebrafish members of the runt family of transcriptional regulators. Experimental Hematology. 30: 1381-9. PMID 12482499 DOI: 10.1016/S0301-472X(02)00955-4  0.172
2010 Shi X, Wang D, Ding K, Lu Z, Jin Y, Zhang J, Pan J. GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. Cancer Biology & Therapy. 9: 640-50. PMID 20160501 DOI: 10.4161/cbt.9.8.11269  0.172
2010 Shi X, Wang D, Ding K, Lu Z, Jin Y, Zhang J, Pan J. GDP366, a novel small molecule dual inhibitor of survivin and Op18, induces cell growth inhibition, cellular senescence and mitotic catastrophe in human cancer cells. Cancer Biology & Therapy. 9: 640-50. PMID 20160501 DOI: 10.4161/cbt.9.8.11269  0.172
2019 Cai W, Wang Z, Cai B, Yuan Y, Kong W, Zhang J, Chen Y, Liu Q, Huang Y, Huang J, Xue W. Expression of PBRM1 as a prognostic predictor in metastatic renal cell carcinoma patients treated with tyrosine kinase inhibitor. International Journal of Clinical Oncology. PMID 31720994 DOI: 10.1007/S10147-019-01564-1  0.172
2002 Lacorazza H, Miyazaki Y, Di Cristofano A, Deblasio A, Hedvat C, Zhang J, Cordon-Cardo C, Mao S, Pandolfi PP, Nimer SD. The ETS Protein MEF Plays a Critical Role in Perforin Gene Expression and the Development of Natural Killer and NK-T Cells Immunity. 17: 437-449. DOI: 10.1016/S1074-7613(02)00422-3  0.172
2018 Muchero W, Sondreli KL, Chen JG, Urbanowicz BR, Zhang J, Singan V, Yang Y, Brueggeman RS, Franco-Coronado J, Abraham N, Yang JY, Moremen KW, Weisberg AJ, Chang JH, Lindquist E, et al. Association mapping, transcriptomics, and transient expression identify candidate genes mediating plant-pathogen interactions in a tree. Proceedings of the National Academy of Sciences of the United States of America. PMID 30337484 DOI: 10.1073/Pnas.1804428115  0.172
2012 Wang SB, Shi Q, Xu Y, Xie WL, Zhang J, Tian C, Guo Y, Wang K, Zhang BY, Chen C, Gao C, Dong XP. Protein disulfide isomerase regulates endoplasmic reticulum stress and the apoptotic process during prion infection and PrP mutant-induced cytotoxicity. Plos One. 7: e38221. PMID 22685557 DOI: 10.1371/journal.pone.0038221  0.172
2018 Bryan AC, Zhang J, Guo J, Ranjan P, Singan V, Barry K, Schmutz J, Weighill D, Jacobson D, Jawdy S, Tuskan GA, Chen JG, Muchero W. A Variable Polyglutamine Repeat Affects Subcellular Localization and Regulatory Activity of a ANGUSTIFOLIA Protein. G3 (Bethesda, Md.). PMID 29884614 DOI: 10.1534/G3.118.200188  0.171
2018 Chang E, Deng N, Zhang J, Liu J, Chen L, Zhao X, Abbas M, Jiang Z, Shi S. Proteome-level analysis of metabolism- and stress-related proteins during seed dormancy and germination in Gnetum parvifolium. Journal of Agricultural and Food Chemistry. PMID 29490456 DOI: 10.1021/acs.jafc.7b05001  0.171
2023 Zhang S, Qu Y, Zhang D, Li S, Tang F, Ding A, Hu L, Zhang J, Wang H, Huang K, Li L. Rational Design and Biological Application of Hybrid Fluorophores. Chemistry (Weinheim An Der Bergstrasse, Germany). e202303208. PMID 38038726 DOI: 10.1002/chem.202303208  0.171
2021 Ahmed S, Tao J, Wang M, Zhai Y, Liu W, Jayachandran M, Chu C, Qu S, Zhang J, Zhang Y, Fei Z. An improved lentiviral system for efficient expression and purification of β-defensins in mammalian cells. Biotechnology Journal. e2100023. PMID 34053189 DOI: 10.1002/biot.202100023  0.171
2018 Song C, Yan H, Wang HM, Zhang Y, Cao H, Wan Y, Kong L, Chen S, Xu H, Pan BX, Zhang J, Fan GH, Xin HB, Liang Z, Jia W, et al. AQR is a novel type 2 diabetes-associated gene that regulates signaling pathways critical for glucose metabolism. Journal of Genetics and Genomics = Yi Chuan Xue Bao. PMID 29502958 DOI: 10.1016/J.Jgg.2017.11.007  0.171
2017 Guo FZ, Xu Y, Ren LH, Zhang J, Zhang F, Duan J, Zhou XQ, Sun ZW. Endosulfan induces apoptosis by activating the negative regulation pathway of cell cycle and death receptor pathway in spermatogenic cells. Toxicology Research. 6: 223-231. PMID 30090493 DOI: 10.1039/c6tx00315j  0.171
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2011 Cairns VR, DeMaria CT, Poulin F, Sancho J, Liu P, Zhang J, Campos-Rivera J, Karey KP, Estes S. Utilization of non-AUG initiation codons in a flow cytometric method for efficient selection of recombinant cell lines. Biotechnology and Bioengineering. 108: 2611-22. PMID 21618473 DOI: 10.1002/bit.23219  0.171
2022 Kumarihamy M, Tripathi S, Balachandran P, Avula B, Zhao J, Wang M, Bennett MM, Zhang J, Carr MA, Lovell KM, Wellington OI, Marquart ME, Nanayakkara NPD, Muhammad I. Synthesis and Inhibitory Activity of Machaeridiol-Based Novel Anti-MRSA and Anti-VRE Compounds and Their Profiling for Cancer-Related Signaling Pathways. Molecules (Basel, Switzerland). 27. PMID 36235141 DOI: 10.3390/molecules27196604  0.171
2008 Wu L, Zhu L, Shi WH, Zhang J, Ma D, Yu B. Zoledronate inhibits the proliferation, adhesion and migration of vascular smooth muscle cells. European Journal of Pharmacology. 602: 124-31. PMID 19000670 DOI: 10.1016/j.ejphar.2008.10.043  0.171
2008 Wu L, Zhu L, Shi WH, Zhang J, Ma D, Yu B. Zoledronate inhibits the proliferation, adhesion and migration of vascular smooth muscle cells. European Journal of Pharmacology. 602: 124-31. PMID 19000670 DOI: 10.1016/j.ejphar.2008.10.043  0.171
2023 Haron MH, Zhang J, Chittiboyina AG, Khan IA, Pugh ND. Validation of a Toll-like Receptor (TLR)2/TLR1 Activation Assay for Biological Standardization of / Immune-Enhancing Potency. Journal of Dietary Supplements. 1-13. PMID 37794652 DOI: 10.1080/19390211.2023.2263566  0.17
2023 Kang C, He H, Liu P, Liu Y, Li X, Zhang J, Ran H, Zeng X, Zhao H, Liu J, Qiu S. Role of dendritic cell‑derived exosomes in allergic rhinitis (Review). International Journal of Molecular Medicine. 52. PMID 37888754 DOI: 10.3892/ijmm.2023.5320  0.17
2019 Zhu Y, Zhang JW, Qi J, Li XW, Chen L, Li MZ, Ma JD. [Molecular regulation mechanism of and in myoblast fusion]. Yi Chuan = Hereditas. 41: 1110-1118. PMID 31857282 DOI: 10.16288/j.yczz.19-232  0.169
2002 Zhang J, Vanhaesebroeck B, Rittenhouse SE. Human platelets contain p110delta phosphoinositide 3-kinase. Biochemical and Biophysical Research Communications. 296: 178-81. PMID 12147247 DOI: 10.1016/s0006-291x(02)00744-1  0.169
2019 Xia W, Hu J, Ma J, Huang J, Jing T, Deng L, Zhang J, Jiang N, Ma D, Ma Z. Mutations in TOP2B cause autosomal-dominant hereditary hearing loss via inhibition of the PI3K-Akt signalling pathway. Febs Letters. PMID 31198993 DOI: 10.1002/1873-3468.13482  0.169
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2002 Carraway KL, Perez A, Idris N, Jepson S, Arango M, Komatsu M, Haq B, Price-Schiavi SA, Zhang J, Carraway CA. Muc4/sialomucin complex, the intramembrane ErbB2 ligand, in cancer and epithelia: to protect and to survive. Progress in Nucleic Acid Research and Molecular Biology. 71: 149-85. PMID 12102554 DOI: 10.1016/S0079-6603(02)71043-X  0.169
2017 Wei Q, He M, Chen M, Chen Z, Yang F, Wang H, Zhang J, He W. Icariin stimulates osteogenic differentiation of rat bone marrow stromal stem cells by increasing TAZ expression. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie. 91: 581-589. PMID 28486190 DOI: 10.1016/j.biopha.2017.04.019  0.169
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