Timothy H. Murphy, Ph.D. - Publications

Affiliations: 
Neuroscience University of British Columbia, Vancouver, Vancouver, BC, Canada 
Area:
Stroke, Vascular System, Dendritic Plasticity, Oxidative Stress
Website:
http://www.neuroscience.ubc.ca/faculty/murphy.html

154 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Cait J, Hughes MR, Zeglinski MR, Chan AW, Osterhof S, Scott RW, Canals Hernaez D, Cait A, Vogl AW, Bernatchez P, Underhill TM, Granville DJ, Murphy TH, Roskelley CD, McNagny KM. Podocalyxin is required for maintaining blood-brain barrier function during acute inflammation. Proceedings of the National Academy of Sciences of the United States of America. PMID 30787191 DOI: 10.1073/pnas.1814766116  0.92
2018 Balbi M, Vanni MP, Vega MJ, Silasi G, Sekino Y, Boyd JD, LeDue JM, Murphy TH. Longitudinal monitoring of mesoscopic cortical activity in a mouse model of microinfarcts reveals dissociations with behavioral and motor function. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X18763428. PMID 29521138 DOI: 10.1177/0271678X18763428  1
2017 Chan AW, Murphy TH. Good Vibrations: Resting-State Functional Connectivity Reflects Entrainment of Vasomotion. Neuron. 96: 716-717. PMID 29144969 DOI: 10.1016/j.neuron.2017.10.035  0.92
2017 Langdon KD, Cordova CA, Granter-Button S, Boyd JD, Peeling J, Murphy TH, Corbett D. Executive dysfunction and blockage of brain microvessels in a rat model of vascular cognitive impairment. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17739219. PMID 29083274 DOI: 10.1177/0271678X17739219  0.84
2017 Silasi G, Boyd J, Bolanos F, LeDue J, Scott SH, Murphy TH. Individualized tracking of self-directed motor learning in group-housed mice performing a skilled lever positioning task in the home cage. Journal of Neurophysiology. jn.00115.2017. PMID 29070625 DOI: 10.1152/jn.00115.2017  1
2017 Woodard CL, Bolaños F, Boyd JD, Silasi G, Murphy TH, Raymond LA. An Automated Home-Cage System to Assess Learning and Performance of a Skilled Motor Task in a Mouse Model of Huntington's Disease. Eneuro. 4. PMID 28929129 DOI: 10.1523/ENEURO.0141-17.2017  1
2017 McGirr A, LeDue J, Chan AW, Xie Y, Murphy TH. Cortical functional hyperconnectivity in a mouse model of depression and selective network effects of ketamine. Brain : a Journal of Neurology. 140: 2210-2225. PMID 28899017 DOI: 10.1093/brain/awx142  0.92
2017 Ardesch DJ, Balbi M, Murphy TH. Automated touch sensing in the mouse tapered beam test using Raspberry Pi. Journal of Neuroscience Methods. PMID 28860079 DOI: 10.1016/j.jneumeth.2017.08.030  0.92
2017 Balbi M, Vanni MP, Silasi G, Sekino Y, Bolanos L, LeDue JM, Murphy TH. Targeted ischemic stroke induction and mesoscopic imaging assessment of blood flow and ischemic depolarization in awake mice. Neurophotonics. 4: 035001. PMID 28721356 DOI: 10.1117/1.NPh.4.3.035001  1
2017 Vanni MP, Chan AW, Balbi M, Silasi G, Murphy TH. Mesoscale mapping of mouse cortex reveals frequency-dependent cycling between distinct macroscale functional modules. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28674167 DOI: 10.1523/JNEUROSCI.3560-16.2017  1
2017 Noorshams O, Boyd JD, Murphy TH. Automating mouse weighing in group homecages with Raspberry Pi micro-computers. Journal of Neuroscience Methods. PMID 28476590 DOI: 10.1016/j.jneumeth.2017.05.002  0.84
2017 Swindale NV, Mitelut C, Murphy TH, Spacek MA. A Visual Guide to Sorting Electrophysiological Recordings Using 'SpikeSorter'. Journal of Visualized Experiments : Jove. PMID 28287541 DOI: 10.3791/55217  0.64
2017 Xiao D, Vanni MP, Mitelut CC, Chan AW, LeDue JM, Xie Y, Chen AC, Swindale NV, Murphy TH. Mapping cortical mesoscopic networks of single spiking cortical or sub-cortical neurons. Elife. 6. PMID 28160463 DOI: 10.7554/eLife.19976  1
2016 McVea DA, Murphy TH, Mohajerani MH. Large Scale Cortical Functional Networks Associated with Slow-Wave and Spindle-Burst-Related Spontaneous Activity. Frontiers in Neural Circuits. 10: 103. PMID 28066190 DOI: 10.3389/fncir.2016.00103  0.88
2016 Bolaños F, LeDue JM, Murphy TH. Cost effective raspberry pi-based radio frequency identification tagging of mice suitable for automated in vivo imaging. Journal of Neuroscience Methods. 276: 79-83. PMID 27899319 DOI: 10.1016/j.jneumeth.2016.11.011  0.8
2016 Connor SA, Ammendrup-Johnsen I, Chan AW, Kishimoto Y, Murayama C, Kurihara N, Tada A, Ge Y, Lu H, Yan R, LeDue JM, Matsumoto H, Kiyonari H, Kirino Y, Matsuzaki F, ... ... Murphy TH, et al. Altered Cortical Dynamics and Cognitive Function upon Haploinsufficiency of the Autism-Linked Excitatory Synaptic Suppressor MDGA2. Neuron. 91: 1052-68. PMID 27608760 DOI: 10.1016/j.neuron.2016.08.016  0.92
2016 Murphy TH, Boyd JD, Bolaños F, Vanni MP, Silasi G, Haupt D, LeDue JM. High-throughput automated home-cage mesoscopic functional imaging of mouse cortex. Nature Communications. 7: 11611. PMID 27291514 DOI: 10.1038/ncomms11611  1
2016 Silasi G, Xiao D, Vanni MP, Chen AC, Murphy TH. Intact skull chronic windows for mesoscopic wide-field imaging in awake mice. Journal of Neuroscience Methods. PMID 27102043 DOI: 10.1016/j.jneumeth.2016.04.012  1
2016 Hilton BJ, Anenberg E, Harrison TC, Boyd JD, Murphy TH, Tetzlaff W. Re-Establishment of Cortical Motor Output Maps and Spontaneous Functional Recovery via Spared Dorsolaterally Projecting Corticospinal Neurons after Dorsal Column Spinal Cord Injury in Adult Mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 4080-92. PMID 27053214 DOI: 10.1523/JNEUROSCI.3386-15.2016  1
2016 Parsons MP, Vanni MP, Woodard CL, Kang R, Murphy TH, Raymond LA. Real-time imaging of glutamate clearance reveals normal striatal uptake in Huntington disease mouse models. Nature Communications. 7: 11251. PMID 27052848 DOI: 10.1038/ncomms11251  1
2016 Xie Y, Chan AW, McGirr A, Xue S, Xiao D, Zeng H, Murphy TH. Resolution of High-Frequency Mesoscale Intracortical Maps Using the Genetically Encoded Glutamate Sensor iGluSnFR. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 36: 1261-72. PMID 26818514 DOI: 10.1523/JNEUROSCI.2744-15.2016  1
2015 Zeng S, Murphy TH. Special Section Guest Editorial:Special Section on Light Microscopy of Connectivity. Neurophotonics. 2: 041401. PMID 26705538 DOI: 10.1117/1.NPh.2.4.041401  0.6
2015 Lacroix A, Toussay X, Anenberg E, Lecrux C, Ferreirós N, Karagiannis A, Plaisier F, Chausson P, Jarlier F, Burgess SA, Hillman EM, Tegeder I, Murphy TH, Hamel E, Cauli B. COX-2-Derived Prostaglandin E2 Produced by Pyramidal Neurons Contributes to Neurovascular Coupling in the Rodent Cerebral Cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 11791-810. PMID 26311764 DOI: 10.1523/JNEUROSCI.0651-15.2015  1
2015 Funayama K, Minamisawa G, Matsumoto N, Ban H, Chan AW, Matsuki N, Murphy TH, Ikegaya Y. Neocortical Rebound Depolarization Enhances Visual Perception. Plos Biology. 13: e1002231. PMID 26274866 DOI: 10.1371/journal.pbio.1002231  1
2015 Chan AW, Mohajerani MH, LeDue JM, Wang YT, Murphy TH. Mesoscale infraslow spontaneous membrane potential fluctuations recapitulate high-frequency activity cortical motifs. Nature Communications. 6: 7738. PMID 26190168 DOI: 10.1038/ncomms8738  1
2015 Lim DH, LeDue JM, Murphy TH. Network analysis of mesoscale optical recordings to assess regional, functional connectivity. Neurophotonics. 2: 041405. PMID 26158019 DOI: 10.1117/1.NPh.2.4.041405  0.88
2015 Anenberg E, Chan AW, Xie Y, LeDue JM, Murphy TH. Optogenetic stimulation of GABA neurons can decrease local neuronal activity while increasing cortical blood flow. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. PMID 26082013 DOI: 10.1038/jcbfm.2015.140  1
2015 Murphy TH. Two-Photon Imaging of Neuronal Structural Plasticity in Mice during and after Ischemia. Cold Spring Harbor Protocols. 2015: pdb.prot087486. PMID 26034310 DOI: 10.1101/pdb.prot087486  1
2015 Silasi G, She J, Boyd JD, Xue S, Murphy TH. A mouse model of small-vessel disease that produces brain-wide-identified microocclusions and regionally selective neuronal injury. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 35: 734-8. PMID 25690472 DOI: 10.1038/jcbfm.2015.8  1
2015 Vanni MP, Chan A, Xiao D, Silasi G, Moshevand M, Ledue J, Murphy TH. Cortical activity motifs that correspond to sensory modalities are organized within larger superclusters Optics and the Brain, Brain 2015 1
2014 Lim DH, LeDue JM, Mohajerani MH, Murphy TH. Optogenetic mapping after stroke reveals network-wide scaling of functional connections and heterogeneous recovery of the peri-infarct. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 16455-66. PMID 25471583 DOI: 10.1523/JNEUROSCI.3384-14.2014  1
2014 Vanni MP, Murphy TH. Mesoscale transcranial spontaneous activity mapping in GCaMP3 transgenic mice reveals extensive reciprocal connections between areas of somatomotor cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 15931-46. PMID 25429135 DOI: 10.1523/JNEUROSCI.1818-14.2014  1
2014 Xie Y, Chen S, Wu Y, Murphy TH. Prolonged deficits in parvalbumin neuron stimulation-evoked network activity despite recovery of dendritic structure and excitability in the somatosensory cortex following global ischemia in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 14890-900. PMID 25378156 DOI: 10.1523/JNEUROSCI.1775-14.2014  1
2014 Silasi G, Murphy TH. Stroke and the connectome: how connectivity guides therapeutic intervention. Neuron. 83: 1354-68. PMID 25233317 DOI: 10.1016/j.neuron.2014.08.052  1
2014 Silasi G, Murphy TH. Removing the brakes on post-stroke plasticity drives recovery from the intact hemisphere and spinal cord. Brain : a Journal of Neurology. 137: 648-50. PMID 24549809 DOI: 10.1093/brain/awu016  1
2014 Harrison TC, Murphy TH. Motor maps and the cortical control of movement. Current Opinion in Neurobiology. 24: 88-94. PMID 24492084 DOI: 10.1016/j.conb.2013.08.018  1
2014 Anenberg E, Arstikaitis P, Niitsu Y, Harrison TC, Boyd JD, Hilton BJ, Tetzlaff W, Murphy TH. Ministrokes in channelrhodopsin-2 transgenic mice reveal widespread deficits in motor output despite maintenance of cortical neuronal excitability. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 1094-104. PMID 24453302 DOI: 10.1523/JNEUROSCI.1442-13.2014  1
2013 Mohajerani MH, Chan AW, Mohsenvand M, LeDue J, Liu R, McVea DA, Boyd JD, Wang YT, Reimers M, Murphy TH. Spontaneous cortical activity alternates between motifs defined by regional axonal projections. Nature Neuroscience. 16: 1426-35. PMID 23974708 DOI: 10.1038/nn.3499  1
2013 Silasi G, Boyd JD, Ledue J, Murphy TH. Improved methods for chronic light-based motor mapping in mice: automated movement tracking with accelerometers, and chronic EEG recording in a bilateral thin-skull preparation. Frontiers in Neural Circuits. 7: 123. PMID 23966910 DOI: 10.3389/fncir.2013.00123  1
2013 Harrison TC, Silasi G, Boyd JD, Murphy TH. Displacement of sensory maps and disorganization of motor cortex after targeted stroke in mice. Stroke; a Journal of Cerebral Circulation. 44: 2300-6. PMID 23743973 DOI: 10.1161/STROKEAHA.113.001272  1
2013 Xie Y, Chen S, Anenberg E, Murphy TH. Resistance of optogenetically evoked motor function to global ischemia and reperfusion in mouse in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 33: 1148-52. PMID 23736644 DOI: 10.1038/jcbfm.2013.89  1
2013 Lim DH, Ledue J, Mohajerani MH, Vanni MP, Murphy TH. Optogenetic approaches for functional mouse brain mapping. Frontiers in Neuroscience. 7: 54. PMID 23596383 DOI: 10.3389/fnins.2013.00054  1
2012 Harrison TC, Murphy TH. Towards a circuit mechanism for movement tuning in motor cortex. Frontiers in Neural Circuits. 6: 127. PMID 23346050 DOI: 10.3389/fncir.2012.00127  1
2012 Chen S, Mohajerani MH, Xie Y, Murphy TH. Optogenetic analysis of neuronal excitability during global ischemia reveals selective deficits in sensory processing following reperfusion in mouse cortex. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13510-9. PMID 23015440 DOI: 10.1523/JNEUROSCI.1439-12.2012  1
2012 McVea DA, Mohajerani MH, Murphy TH. Voltage-sensitive dye imaging reveals dynamic spatiotemporal properties of cortical activity after spontaneous muscle twitches in the newborn rat. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 10982-94. PMID 22875932 DOI: 10.1523/JNEUROSCI.1322-12.2012  1
2012 Xie Y, Chen S, Murphy T. Dendritic spines and pre-synaptic boutons are stable despite local deep hypothermic challenge and re-warming in vivo. Plos One. 7: e36305. PMID 22563488 DOI: 10.1371/journal.pone.0036305  1
2012 Harrison TC, Ayling OG, Murphy TH. Distinct cortical circuit mechanisms for complex forelimb movement and motor map topography. Neuron. 74: 397-409. PMID 22542191 DOI: 10.1016/j.neuron.2012.02.028  1
2012 Lim DH, Mohajerani MH, Ledue J, Boyd J, Chen S, Murphy TH. In vivo Large-Scale Cortical Mapping Using Channelrhodopsin-2 Stimulation in Transgenic Mice Reveals Asymmetric and Reciprocal Relationships between Cortical Areas. Frontiers in Neural Circuits. 6: 11. PMID 22435052 DOI: 10.3389/fncir.2012.00011  1
2012 Scott NA, Murphy TH, Illes J. Incidental findings in neuroimaging research: a framework for anticipating the next frontier. Journal of Empirical Research On Human Research Ethics : Jerhre. 7: 53-7. PMID 22378134 DOI: 10.1525/jer.2012.7.1.53  1
2012 Scott NA, Murphy TH. Hemodynamic responses evoked by neuronal stimulation via channelrhodopsin-2 can be independent of intracortical glutamatergic synaptic transmission. Plos One. 7: e29859. PMID 22253807 DOI: 10.1371/journal.pone.0029859  1
2012 Tran S, Chen S, Liu RR, Xie Y, Murphy TH. Moderate or deep local hypothermia does not prevent the onset of ischemia-induced dendritic damage. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 32: 437-42. PMID 22167237 DOI: 10.1038/jcbfm.2011.178  1
2011 Mohajerani MH, Aminoltejari K, Murphy TH. Targeted mini-strokes produce changes in interhemispheric sensory signal processing that are indicative of disinhibition within minutes. Proceedings of the National Academy of Sciences of the United States of America. 108: E183-91. PMID 21576480 DOI: 10.1073/pnas.1101914108  1
2011 Arstikaitis P, Gauthier-Campbell C, Huang K, El-Husseini A, Murphy TH. Proteins that promote filopodia stability, but not number, lead to more axonal-dendritic contacts. Plos One. 6: e16998. PMID 21408225 DOI: 10.1371/journal.pone.0016998  1
2011 Takahashi H, Arstikaitis P, Prasad T, Bartlett TE, Wang YT, Murphy TH, Craig AM. Postsynaptic TrkC and presynaptic PTPσ function as a bidirectional excitatory synaptic organizing complex. Neuron. 69: 287-303. PMID 21262467 DOI: 10.1016/j.neuron.2010.12.024  1
2011 Chen S, Tran S, Sigler A, Murphy TH. Automated and quantitative image analysis of ischemic dendritic blebbing using in vivo 2-photon microscopy data. Journal of Neuroscience Methods. 195: 222-31. PMID 21184780 DOI: 10.1016/j.jneumeth.2010.12.018  1
2011 Scott NA, Murphy TH. Glial laminar cortical architecture matches metabolic demand. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 31: 793-4. PMID 21139627 DOI: 10.1038/jcbfm.2010.205  1
2010 Sigler A, Murphy TH. In vivo 2-photon imaging of fine structure in the rodent brain: before, during, and after stroke. Stroke; a Journal of Cerebral Circulation. 41: S117-23. PMID 20876484 DOI: 10.1161/STROKEAHA.110.594648  1
2010 Haskew-Layton RE, Payappilly JB, Smirnova NA, Ma TC, Chan KK, Murphy TH, Guo H, Langley B, Sultana R, Butterfield DA, Santagata S, Alldred MJ, Gazaryan IG, Bell GW, Ginsberg SD, et al. Controlled enzymatic production of astrocytic hydrogen peroxide protects neurons from oxidative stress via an Nrf2-independent pathway. Proceedings of the National Academy of Sciences of the United States of America. 107: 17385-90. PMID 20855618 DOI: 10.1073/pnas.1003996107  1
2010 Mohajerani MH, McVea DA, Fingas M, Murphy TH. Mirrored bilateral slow-wave cortical activity within local circuits revealed by fast bihemispheric voltage-sensitive dye imaging in anesthetized and awake mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 3745-51. PMID 20220008 DOI: 10.1523/JNEUROSCI.6437-09.2010  1
2010 Milnerwood AJ, Gladding CM, Pouladi MA, Kaufman AM, Hines RM, Boyd JD, Ko RW, Vasuta OC, Graham RK, Hayden MR, Murphy TH, Raymond LA. Early increase in extrasynaptic NMDA receptor signaling and expression contributes to phenotype onset in Huntington's disease mice. Neuron. 65: 178-90. PMID 20152125 DOI: 10.1016/j.neuron.2010.01.008  1
2010 Brown CE, Boyd JD, Murphy TH. Longitudinal in vivo imaging reveals balanced and branch-specific remodeling of mature cortical pyramidal dendritic arbors after stroke. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 30: 783-91. PMID 19920846 DOI: 10.1038/jcbfm.2009.241  1
2010 Milnerwood AJ, Gladding CM, Pouladi MA, Kaufman AM, Hines RM, Boyd JD, Ko RWY, Vasuta OC, Graham RK, Hayden MR, Murphy TH, Raymond LA. Early Increase in Extrasynaptic NMDA Receptor Signaling and Expression Contributes to Phenotype Onset in Huntington's Disease Mice (DOI:10.1016/j.neuron.2010.01.008) Neuron. 65: 436. DOI: 10.1016/j.neuron.2010.01.031  1
2009 Liu RR, Murphy TH. Reversible cyclosporin A-sensitive mitochondrial depolarization occurs within minutes of stroke onset in mouse somatosensory cortex in vivo: a two-photon imaging study. The Journal of Biological Chemistry. 284: 36109-17. PMID 19892710 DOI: 10.1074/jbc.M109.055301  1
2009 Murphy TH, Corbett D. Plasticity during stroke recovery: from synapse to behaviour. Nature Reviews. Neuroscience. 10: 861-72. PMID 19888284 DOI: 10.1038/nrn2735  1
2009 Winship IR, Murphy TH. Remapping the somatosensory cortex after stroke: insight from imaging the synapse to network. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 15: 507-24. PMID 19622841 DOI: 10.1177/1073858409333076  1
2009 Sigler A, Mohajerani MH, Murphy TH. Imaging rapid redistribution of sensory-evoked depolarization through existing cortical pathways after targeted stroke in mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 11759-64. PMID 19571005 DOI: 10.1073/pnas.0812695106  1
2009 Harrison TC, Sigler A, Murphy TH. Simple and cost-effective hardware and software for functional brain mapping using intrinsic optical signal imaging. Journal of Neuroscience Methods. 182: 211-8. PMID 19559049 DOI: 10.1016/j.jneumeth.2009.06.021  1
2009 Ayling OG, Harrison TC, Boyd JD, Goroshkov A, Murphy TH. Automated light-based mapping of motor cortex by photoactivation of channelrhodopsin-2 transgenic mice. Nature Methods. 6: 219-24. PMID 19219033 DOI: 10.1038/nmeth.1303  1
2009 Brown CE, Aminoltejari K, Erb H, Winship IR, Murphy TH. In vivo voltage-sensitive dye imaging in adult mice reveals that somatosensory maps lost to stroke are replaced over weeks by new structural and functional circuits with prolonged modes of activation within both the peri-infarct zone and distant sites. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 1719-34. PMID 19211879 DOI: 10.1523/JNEUROSCI.4249-08.2009  1
2008 Li P, Murphy TH. Two-photon imaging during prolonged middle cerebral artery occlusion in mice reveals recovery of dendritic structure after reperfusion. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 11970-9. PMID 19005062 DOI: 10.1523/JNEUROSCI.3724-08.2008  1
2008 Winship IR, Murphy TH. In vivo calcium imaging reveals functional rewiring of single somatosensory neurons after stroke. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 6592-606. PMID 18579732 DOI: 10.1523/JNEUROSCI.0622-08.2008  1
2008 Brown CE, Wong C, Murphy TH. Rapid morphologic plasticity of peri-infarct dendritic spines after focal ischemic stroke. Stroke; a Journal of Cerebral Circulation. 39: 1286-91. PMID 18323506 DOI: 10.1161/STROKEAHA.107.498238  1
2008 Sigler A, Goroshkov A, Murphy TH. Hardware and methodology for targeting single brain arterioles for photothrombotic stroke on an upright microscope. Journal of Neuroscience Methods. 170: 35-44. PMID 18289696 DOI: 10.1016/j.jneumeth.2007.12.015  1
2008 Arstikaitis P, Gauthier-Campbell C, Carolina Gutierrez Herrera R, Huang K, Levinson JN, Murphy TH, Kilimann MW, Sala C, Colicos MA, El-Husseini A. Paralemmin-1, a modulator of filopodia induction is required for spine maturation. Molecular Biology of the Cell. 19: 2026-38. PMID 18287537 DOI: 10.1091/mbc.E07-08-0802  1
2008 Murphy TH, Li P, Betts K, Liu R. Two-photon imaging of stroke onset in vivo reveals that NMDA-receptor independent ischemic depolarization is the major cause of rapid reversible damage to dendrites and spines. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 1756-72. PMID 18272696 DOI: 10.1523/JNEUROSCI.5128-07.2008  1
2008 Brown CE, Murphy TH. Livin' on the edge: imaging dendritic spine turnover in the peri-infarct zone during ischemic stroke and recovery. The Neuroscientist : a Review Journal Bringing Neurobiology, Neurology and Psychiatry. 14: 139-46. PMID 18039977 DOI: 10.1177/1073858407309854  1
2007 Liu RR, Brown CE, Murphy TH. Differential regulation of cell proliferation in neurogenic zones in mice lacking cystine transport by xCT. Biochemical and Biophysical Research Communications. 364: 528-33. PMID 17963724 DOI: 10.1016/j.bbrc.2007.10.036  1
2007 Winship IR, Plaa N, Murphy TH. Rapid astrocyte calcium signals correlate with neuronal activity and onset of the hemodynamic response in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6268-72. PMID 17554000 DOI: 10.1523/JNEUROSCI.4801-06.2007  1
2007 Liu Z, Otsu Y, Vasuta C, Nawa H, Murphy TH. Action-potential-independent GABAergic tone mediated by nicotinic stimulation of immature striatal miniature synaptic transmission. Journal of Neurophysiology. 98: 581-93. PMID 17553945 DOI: 10.1152/jn.00768.2006  1
2007 Awatramani GB, Boyd JD, Delaney KR, Murphy TH. Effective release rates at single rat Schaffer collateral-CA1 synapses during sustained theta-burst activity revealed by optical imaging. The Journal of Physiology. 582: 583-95. PMID 17463045 DOI: 10.1113/jphysiol.2007.130286  1
2007 Zhang S, Murphy TH. Imaging the impact of cortical microcirculation on synaptic structure and sensory-evoked hemodynamic responses in vivo. Plos Biology. 5: e119. PMID 17456007 DOI: 10.1371/journal.pbio.0050119  1
2007 Brown CE, Li P, Boyd JD, Delaney KR, Murphy TH. Extensive turnover of dendritic spines and vascular remodeling in cortical tissues recovering from stroke. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 4101-9. PMID 17428988 DOI: 10.1523/JNEUROSCI.4295-06.2007  1
2007 Shih AY, Erb H, Murphy TH. Dopamine activates Nrf2-regulated neuroprotective pathways in astrocytes and meningeal cells. Journal of Neurochemistry. 101: 109-19. PMID 17394461 DOI: 10.1111/j.1471-4159.2006.04345.x  1
2007 Enright LE, Zhang S, Murphy TH. Fine mapping of the spatial relationship between acute ischemia and dendritic structure indicates selective vulnerability of layer V neuron dendritic tufts within single neurons in vivo. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 27: 1185-200. PMID 17164811 DOI: 10.1038/sj.jcbfm.9600428  1
2007 Pacchioni AM, Vallone J, Melendez RI, Shih A, Murphy TH, Kalivas PW. Nrf2 gene deletion fails to alter psychostimulant-induced behavior or neurotoxicity. Brain Research. 1127: 26-35. PMID 17113054 DOI: 10.1016/j.brainres.2006.10.036  1
2006 Shih AY, Erb H, Sun X, Toda S, Kalivas PW, Murphy TH. Cystine/glutamate exchange modulates glutathione supply for neuroprotection from oxidative stress and cell proliferation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 10514-23. PMID 17035536 DOI: 10.1523/JNEUROSCI.3178-06.2006  1
2006 Sun X, Shih AY, Johannssen HC, Erb H, Li P, Murphy TH. Two-photon imaging of glutathione levels in intact brain indicates enhanced redox buffering in developing neurons and cells at the cerebrospinal fluid and blood-brain interface. The Journal of Biological Chemistry. 281: 17420-31. PMID 16624809 DOI: 10.1074/jbc.M601567200  1
2005 Shih AY, Li P, Murphy TH. A small-molecule-inducible Nrf2-mediated antioxidant response provides effective prophylaxis against cerebral ischemia in vivo. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10321-35. PMID 16267240 DOI: 10.1523/JNEUROSCI.4014-05.2005  1
2005 Zhang S, Boyd J, Delaney K, Murphy TH. Rapid reversible changes in dendritic spine structure in vivo gated by the degree of ischemia. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 5333-8. PMID 15930381 DOI: 10.1523/JNEUROSCI.1085-05.2005  1
2005 Shih AY, Imbeault S, Barakauskas V, Erb H, Jiang L, Li P, Murphy TH. Induction of the Nrf2-driven antioxidant response confers neuroprotection during mitochondrial stress in vivo. The Journal of Biological Chemistry. 280: 22925-36. PMID 15840590 DOI: 10.1074/jbc.M414635200  1
2005 Sun X, Erb H, Murphy TH. Coordinate regulation of glutathione metabolism in astrocytes by Nrf2. Biochemical and Biophysical Research Communications. 326: 371-7. PMID 15582588 DOI: 10.1016/j.bbrc.2004.11.031  1
2005 Isope P, Murphy TH. Low threshold calcium currents in rat cerebellar Purkinje cell dendritic spines are mediated by T-type calcium channels. The Journal of Physiology. 562: 257-69. PMID 15513942 DOI: 10.1113/jphysiol.2004.074211  1
2004 Awatramani G, Murphy TH. Selective reduction of weak synaptic activity awakens dormant synapses. Neuron. 44: 743-4. PMID 15572104 DOI: 10.1016/j.neuron.2004.11.021  1
2004 Otsu Y, Murphy TH. Optical postsynaptic measurement of vesicle release rates for hippocampal synapses undergoing asynchronous release during train stimulation. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 9076-86. PMID 15483126 DOI: 10.1523/JNEUROSCI.2060-04.2004  1
2004 Li L, Murphy TH, Hayden MR, Raymond LA. Enhanced striatal NR2B-containing N-methyl-D-aspartate receptor-mediated synaptic currents in a mouse model of Huntington disease. Journal of Neurophysiology. 92: 2738-46. PMID 15240759 DOI: 10.1152/jn.00308.2004  1
2004 Zhang S, Murphy TH. Ca(2+)-independent spine dynamics in cultured hippocampal neurons. Molecular and Cellular Neurosciences. 25: 334-44. PMID 15019949 DOI: 10.1016/j.mcn.2003.10.017  1
2004 Gauthier-Campbell C, Bredt DS, Murphy TH, El-Husseini Ael-D. Regulation of dendritic branching and filopodia formation in hippocampal neurons by specific acylated protein motifs. Molecular Biology of the Cell. 15: 2205-17. PMID 14978216 DOI: 10.1091/mbc.E03-07-0493  1
2004 Otsu Y, Shahrezaei V, Li B, Raymond LA, Delaney KR, Murphy TH. Competition between phasic and asynchronous release for recovered synaptic vesicles at developing hippocampal autaptic synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 420-33. PMID 14724240 DOI: 10.1523/JNEUROSCI.4452-03.2004  1
2004 Chen N, Li B, Murphy TH, Raymond LA. Site within N-Methyl-D-aspartate receptor pore modulates channel gating. Molecular Pharmacology. 65: 157-64. PMID 14722247 DOI: 10.1124/mol.65.1.157  1
2003 Otsu Y, Murphy TH. Miniature transmitter release: accident of nature or careful design? Science's Stke : Signal Transduction Knowledge Environment. 2003: pe54. PMID 14657459 DOI: 10.1126/stke.2112003pe54  1
2003 Li B, Otsu Y, Murphy TH, Raymond LA. Developmental decrease in NMDA receptor desensitization associated with shift to synapse and interaction with postsynaptic density-95. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 11244-54. PMID 14657184  1
2003 Li L, Fan M, Icton CD, Chen N, Leavitt BR, Hayden MR, Murphy TH, Raymond LA. Role of NR2B-type NMDA receptors in selective neurodegeneration in Huntington disease. Neurobiology of Aging. 24: 1113-21. PMID 14643383 DOI: 10.1016/j.neurobiolaging.2003.04.003  0.52
2003 Liu Z, Ren J, Murphy TH. Decoding of synaptic voltage waveforms by specific classes of recombinant high-threshold Ca(2+) channels. The Journal of Physiology. 553: 473-88. PMID 14500770 DOI: 10.1113/jphysiol.2003.051110  1
2003 Lee JM, Shih AY, Murphy TH, Johnson JA. NF-E2-related factor-2 mediates neuroprotection against mitochondrial complex I inhibitors and increased concentrations of intracellular calcium in primary cortical neurons. The Journal of Biological Chemistry. 278: 37948-56. PMID 12842875 DOI: 10.1074/jbc.M305204200  1
2003 Otsu Y, Murphy TH. Mind-altering miniature neurotransmitter release? Proceedings of the National Academy of Sciences of the United States of America. 100: 5589-90. PMID 12732714 DOI: 10.1073/pnas.1131911100  1
2003 Shih AY, Johnson DA, Wong G, Kraft AD, Jiang L, Erb H, Johnson JA, Murphy TH. Coordinate regulation of glutathione biosynthesis and release by Nrf2-expressing glia potently protects neurons from oxidative stress. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 3394-406. PMID 12716947  1
2003 Murphy TH. Activity-dependent synapse development: changing the rules. Nature Neuroscience. 6: 9-11. PMID 12494242 DOI: 10.1038/nn0103-9  1
2002 Li B, Chen N, Luo T, Otsu Y, Murphy TH, Raymond LA. Differential regulation of synaptic and extra-synaptic NMDA receptors. Nature Neuroscience. 5: 833-4. PMID 12195433 DOI: 10.1038/nn912  1
2002 Wang S, Jia Z, Roder J, Murphy TH. AMPA receptor-mediated miniature synaptic calcium transients in GluR2 null mice. Journal of Neurophysiology. 88: 29-40. PMID 12091530  1
2001 Prange O, Murphy TH. Modular transport of postsynaptic density-95 clusters and association with stable spine precursors during early development of cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 9325-33. PMID 11717366  1
2001 Laxton AW, Sun MC, Shen H, Murphy TH, Honey CR. The antioxidant enzyme quinone reductase is up-regulated in vivo following cerebral ischemia. Neuroreport. 12: 1045-8. PMID 11303743  1
2001 Shih AY, Murphy TH. xCt cystine transporter expression in HEK293 cells: pharmacology and localization. Biochemical and Biophysical Research Communications. 282: 1132-7. PMID 11302733 DOI: 10.1006/bbrc.2001.4703  1
2001 Murphy TH, Yu J, Ng R, Johnson DA, Shen H, Honey CR, Johnson JA. Preferential expression of antioxidant response element mediated gene expression in astrocytes. Journal of Neurochemistry. 76: 1670-8. PMID 11259485 DOI: 10.1046/j.1471-4159.2001.00157.x  1
2001 Chen N, Ren J, Raymond LA, Murphy TH. Changes in agonist concentration dependence that are a function of duration of exposure suggest N-methyl-D-aspartate receptor nonsaturation during synaptic stimulation. Molecular Pharmacology. 59: 212-9. PMID 11160855  1
2001 Umemiya M, Chen N, Raymond LA, Murphy TH. A calcium-dependent feedback mechanism participates in shaping single NMDA miniature EPSCs. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1-9. PMID 11150313  1
2000 Chen N, Murphy TH, Raymond LA. Competitive inhibition of NMDA receptor-mediated currents by extracellular calcium chelators. Journal of Neurophysiology. 84: 693-7. PMID 10938296  1
2000 Mackenzie PJ, Kenner GS, Prange O, Murphy TH. Vesicle number does not predict postsynaptic measures of miniature synaptic activity frequency in cultured cortical neurons. Neuroscience. 98: 1-7. PMID 10858606 DOI: 10.1016/S0306-4522(00)00089-0  1
1999 Wang S, Prange O, Murphy TH. Amplification of calcium signals at dendritic spines provides a method for CNS quantal analysis. Canadian Journal of Physiology and Pharmacology. 77: 651-9. PMID 10566942  1
1999 Umemiya M, Senda M, Murphy TH. Behaviour of NMDA and AMPA receptor-mediated miniature EPSCs at rat cortical neuron synapses identified by calcium imaging. The Journal of Physiology. 521: 113-22. PMID 10562338  1
1999 Sutton KG, McRory JE, Guthrie H, Murphy TH, Snutch TP. P/Q-type calcium channels mediate the activity-dependent feedback of syntaxin-1A. Nature. 401: 800-4. PMID 10548106 DOI: 10.1038/44586  1
1999 Su JY, Duffy S, Murphy TH. Reduction of H2O2-evoked, intracellular calcium increases in the rat N18-RE-105 neuronal cell line by pretreatment with an electrophilic antioxidant inducer. Neuroscience Letters. 273: 109-12. PMID 10505628 DOI: 10.1016/S0304-3940(99)00634-5  1
1999 Nakazawa H, Murphy TH. Activation of nuclear calcium dynamics by synaptic stimulation in cultured cortical neurons. Journal of Neurochemistry. 73: 1075-83. PMID 10461897 DOI: 10.1046/j.1471-4159.1999.0731075.x  1
1999 Prange O, Murphy TH. Correlation of miniature synaptic activity and evoked release probability in cultures of cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: 6427-38. PMID 10414971  1
1999 Mackenzie PJ, Kenner GS, Prange O, Shayan H, Umemiya M, Murphy TH. Ultrastructural correlates of quantal synaptic function at single CNS synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 19: RC13. PMID 10366651  1
1999 Prange O, Murphy TH. Analysis of multiquantal transmitter release from single cultured cortical neuron terminals. Journal of Neurophysiology. 81: 1810-7. PMID 10200215  1
1999 Shayan H, Murphy TH. Restriction of peroxidase-mediated antibody reactivity to single neurons by local hydrogen peroxide production. Neuroscience. 89: 279-90. PMID 10051235 DOI: 10.1016/S0306-4522(98)00323-6  1
1998 Mackenzie PJ, Murphy TH. High safety factor for action potential conduction along axons but not dendrites of cultured hippocampal and cortical neurons. Journal of Neurophysiology. 80: 2089-101. PMID 9772263  1
1998 Duffy S, So A, Murphy TH. Activation of endogenous antioxidant defenses in neuronal cells prevents free radical-mediated damage. Journal of Neurochemistry. 71: 69-77. PMID 9648852  1
1998 Murphy TH, So AP, Vincent SR. Histochemical detection of quinone reductase activity in situ using LY 83583 reduction and oxidation. Journal of Neurochemistry. 70: 2156-64. PMID 9572303  1
1997 Ho DT, Shayan H, Murphy TH. Okadaic acid induces hyperphosphorylation of tau independently of mitogen-activated protein kinase activation. Journal of Neurochemistry. 68: 106-11. PMID 8978715  1
1996 Mackenzie PJ, Umemiya M, Murphy TH. Ca2+ imaging of CNS axons in culture indicates reliable coupling between single action potentials and distal functional release sites. Neuron. 16: 783-95. PMID 8607996 DOI: 10.1016/S0896-6273(00)80098-7  1
1995 Murphy TH, Baraban JM, Wier WG. Mapping miniature synaptic currents to single synapses using calcium imaging reveals heterogeneity in postsynaptic output. Neuron. 15: 159-68. PMID 7619520 DOI: 10.1016/0896-6273(95)90073-X  1
1995 Murphy TH, Baraban JM. Deciphering the role of novel kinase cascades in neuronal signalling Neurobiology of Aging. 16: 257-261. DOI: 10.1016/0197-4580(94)00188-7  1
1994 Murphy TH, Blatter LA, Bhat RV, Fiore RS, Wier WG, Baraban JM. Differential regulation of calcium/calmodulin-dependent protein kinase II and p42 MAP kinase activity by synaptic transmission. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 1320-31. PMID 8120627  1
1994 Ratan RR, Murphy TH, Baraban JM. Macromolecular synthesis inhibitors prevent oxidative stress-induced apoptosis in embryonic cortical neurons by shunting cysteine from protein synthesis to glutathione. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 4385-92. PMID 8027786  1
1994 Murphy TH, Baraban JM, Wier WG, Blatter LA. Visualization of quantal synaptic transmission by dendritic calcium imaging. Science (New York, N.Y.). 263: 529-32. PMID 7904774  1
1994 Ratan RR, Murphy TH, Baraban JM. Oxidative stress induces apoptosis in embryonic cortical neurons. Journal of Neurochemistry. 62: 376-9. PMID 7903353  1
1994 Blackstone C, Murphy TH, Moss SJ, Baraban JM, Huganir RL. Cyclic AMP and synaptic activity-dependent phosphorylation of AMPA-preferring glutamate receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 14: 7585-93. PMID 7527845  1
1993 Murphy TH, Blatter LA, Wier WG, Baraban JM. Rapid communication between neurons and astrocytes in primary cortical cultures. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 13: 2672-9. PMID 8501531  1
1993 Fiore RS, Murphy TH, Sanghera JS, Pelech SL, Baraban JM. Activation of p42 mitogen-activated protein kinase by glutamate receptor stimulation in rat primary cortical cultures. Journal of Neurochemistry. 61: 1626-33. PMID 7693864  1
1992 Murphy TH, Blatter LA, Wier WG, Baraban JM. Spontaneous synchronous synaptic calcium transients in cultured cortical neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 12: 4834-45. PMID 1361198  1
1992 Murphy TH, Wright DD, Baraban JM. Phosphoinositide turnover associated with synaptic transmission. Journal of Neurochemistry. 59: 2336-9. PMID 1331330  1
1991 Murphy TH, Worley PF, Nakabeppu Y, Christy B, Gastel J, Baraban JM. Synaptic regulation of immediate early gene expression in primary cultures of cortical neurons. Journal of Neurochemistry. 57: 1862-72. PMID 1719131  1
1991 Murphy TH, De Long MJ, Coyle JT. Enhanced NAD(P)H:quinone reductase activity prevents glutamate toxicity produced by oxidative stress. Journal of Neurochemistry. 56: 990-5. PMID 1704427  1
1991 Coyle JT, Murphy TH, Puttfarcken PS, Lyons EW, Vornov JJ. The non-excitatory mechanisms of glutamate induced neurotoxicity. Epilepsy Research. 10: 41-8. PMID 1686428 DOI: 10.1016/0920-1211(91)90093-U  1
1991 Murphy TH, Worley PF, Baraban JM. L-type voltage-sensitive calcium channels mediate synaptic activation of immediate early genes. Neuron. 7: 625-35. PMID 1657056 DOI: 10.1016/0896-6273(91)90375-A  1
1990 Murphy TH, Schnaar RL, Coyle JT. Immature cortical neurons are uniquely sensitive to glutamate toxicity by inhibition of cystine uptake. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 4: 1624-33. PMID 2180770  1
1990 Worley PF, Cole AJ, Murphy TH, Christy BA, Nakabeppu Y, Baraban JM. Synaptic regulation of immediate-early genes in brain. Cold Spring Harbor Symposia On Quantitative Biology. 55: 213-23. PMID 2151923  1
1990 Murphy TH, Baraban JM. Glutamate toxicity in immature cortical neurons precedes development of glutamate receptor currents. Brain Research. Developmental Brain Research. 57: 146-50. PMID 1982523 DOI: 10.1016/0165-3806(90)90195-5  1
1989 Miyamoto M, Murphy TH, Schnaar RL, Coyle JT. Antioxidants protect against glutamate-induced cytotoxicity in a neuronal cell line. The Journal of Pharmacology and Experimental Therapeutics. 250: 1132-40. PMID 2778712  1
1989 Murphy TH, Miyamoto M, Sastre A, Schnaar RL, Coyle JT. Glutamate toxicity in a neuronal cell line involves inhibition of cystine transport leading to oxidative stress. Neuron. 2: 1547-58. PMID 2576375 DOI: 10.1016/0896-6273(89)90043-3  1
1988 Murphy TH, Schnaar RL, Coyle JT, Sastre A. Glutamate cytotoxicity in a neuronal cell line is blocked by membrane depolarization. Brain Research. 460: 155-60. PMID 2905921 DOI: 10.1016/0006-8993(88)91216-4  1
1988 Murphy TH, Malouf AT, Sastre A, Schnaar RL, Coyle JT. Calcium-dependent glutamate cytotoxicity in a neuronal cell line. Brain Research. 444: 325-32. PMID 2896063 DOI: 10.1016/0006-8993(88)90941-9  1
1986 ffrench-Mullen JM, Murphy TH, Coyle JT, Fisher RS. Dicarboxylic amino acids block epileptiform activity in hippocampal slice. Epilepsia. 27: 678-84. PMID 2877868  1
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