Scott Zeitlin - Publications

University of Virginia, Charlottesville, VA 
Neuroscience Biology

48 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Marchionini DM, Liu JP, Ambesi-Impiombato A, Kerker K, Cirillo K, Bansal M, Mushlin R, Brunner D, Ramboz S, Kwan M, Kuhlbrodt K, Tillack K, Peters F, Rauhala L, Obenauer J, ... ... Zeitlin SO, et al. Benefits of global mutant huntingtin lowering diminish over time in a Huntington's disease mouse model. Jci Insight. 7. PMID 36278490 DOI: 10.1172/jci.insight.161769  0.312
2022 Greco TM, Secker C, Ramos ES, Federspiel JD, Liu JP, Perez AM, Al-Ramahi I, Cantle JP, Carroll JB, Botas J, Zeitlin SO, Wanker EE, Cristea IM. Dynamics of huntingtin protein interactions in the striatum identifies candidate modifiers of Huntington disease. Cell Systems. PMID 35148841 DOI: 10.1016/j.cels.2022.01.005  0.38
2021 Braatz EM, André EA, Liu JP, Zeitlin SO. Characterization of a Knock-In Mouse Model with a Huntingtin Exon 1 Deletion. Journal of Huntington's Disease. PMID 34459410 DOI: 10.3233/JHD-210494  0.304
2020 Barnat M, Capizzi M, Aparicio E, Boluda S, Wennagel D, Kacher R, Kassem R, Lenoir S, Agasse F, Braz BY, Liu JP, Ighil J, Tessier A, Zeitlin SO, Duyckaerts C, et al. Huntington's disease alters human neurodevelopment. Science (New York, N.Y.). PMID 32675289 DOI: 10.1126/Science.Aax3338  0.333
2020 Burrus CJ, McKinstry SU, Kim N, Ozlu MI, Santoki AV, Fang FY, Ma A, Karadeniz YB, Worthington AK, Dragatsis I, Zeitlin S, Yin HH, Eroglu C. Striatal Projection Neurons Require Huntingtin for Synaptic Connectivity and Survival. Cell Reports. 30: 642-657.e6. PMID 31968243 DOI: 10.1016/J.Celrep.2019.12.069  0.486
2019 Franich NR, Hickey MA, Zhu C, Osborne GF, Ali N, Chu T, Bove NH, Lemesre V, Lerner RP, Zeitlin SO, Howland D, Neueder A, Landles C, Bates GP, Chesselet MF. Phenotype onset in Huntington's disease knock-in mice is correlated with the incomplete splicing of the mutant huntingtin gene. Journal of Neuroscience Research. PMID 31282030 DOI: 10.1002/Jnr.24493  0.53
2018 Franich NR, Basso M, André EA, Ochaba J, Kumar A, Thein S, Fote G, Kachemov M, Lau AL, Yeung SY, Osmand A, Zeitlin SO, Ratan RR, Thompson LM, Steffan JS. Striatal Mutant Huntingtin Protein Levels Decline with Age in Homozygous Huntington's Disease Knock-In Mouse Models. Journal of Huntington's Disease. PMID 29843246 DOI: 10.3233/Jhd-170274  0.388
2017 Liu JP, Zeitlin SO. Is Huntingtin Dispensable in the Adult Brain? Journal of Huntington's Disease. PMID 28339401 DOI: 10.3233/JHD-170235  0.365
2017 André EA, Braatz EM, Liu JP, Zeitlin SO. Generation and Characterization of Knock-in Mouse Models Expressing Versions of Huntingtin with Either an N17 or a Combined PolyQ and Proline-Rich Region Deletion. Journal of Huntington's Disease. PMID 28211815 DOI: 10.3233/JHD-160231  0.307
2014 Ochaba J, Lukacsovich T, Csikos G, Zheng S, Margulis J, Salazar L, Mao K, Lau AL, Yeung SY, Humbert S, Saudou F, Klionsky DJ, Finkbeiner S, Zeitlin SO, Marsh JL, et al. Potential function for the Huntingtin protein as a scaffold for selective autophagy. Proceedings of the National Academy of Sciences of the United States of America. 111: 16889-94. PMID 25385587 DOI: 10.1073/Pnas.1420103111  0.379
2014 McKinstry SU, Karadeniz YB, Worthington AK, Hayrapetyan VY, Ozlu MI, Serafin-Molina K, Risher WC, Ustunkaya T, Dragatsis I, Zeitlin S, Yin HH, Eroglu C. Huntingtin is required for normal excitatory synapse development in cortical and striatal circuits. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 9455-72. PMID 25009276 DOI: 10.1523/Jneurosci.4699-13.2014  0.376
2013 Conforti P, Camnasio S, Mutti C, Valenza M, Thompson M, Fossale E, Zeitlin S, MacDonald ME, Zuccato C, Cattaneo E. Lack of huntingtin promotes neural stem cells differentiation into glial cells while neurons expressing huntingtin with expanded polyglutamine tracts undergo cell death. Neurobiology of Disease. 50: 160-70. PMID 23089356 DOI: 10.1016/J.Nbd.2012.10.015  0.384
2012 Neveklovska M, Clabough EB, Steffan JS, Zeitlin SO. Deletion of the huntingtin proline-rich region does not significantly affect normal huntingtin function in mice. Journal of Huntington's Disease. 1: 71-87. PMID 22956985 DOI: 10.3233/JHD-2012-120016  0.708
2012 Zheng S, Ghitani N, Blackburn JS, Liu JP, Zeitlin SO. A series of N-terminal epitope tagged Hdh knock-in alleles expressing normal and mutant huntingtin: their application to understanding the effect of increasing the length of normal Huntingtin's polyglutamine stretch on CAG140 mouse model pathogenesis. Molecular Brain. 5: 28. PMID 22892315 DOI: 10.1186/1756-6606-5-28  0.538
2012 Culver BP, Savas JN, Park SK, Choi JH, Zheng S, Zeitlin SO, Yates JR, Tanese N. Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis. The Journal of Biological Chemistry. 287: 21599-614. PMID 22556411 DOI: 10.1074/Jbc.M112.359307  0.405
2012 Ritch JJ, Valencia A, Alexander J, Sapp E, Gatune L, Sangrey GR, Sinha S, Scherber CM, Zeitlin S, Sadri-Vakili G, Irimia D, Difiglia M, Kegel KB. Multiple phenotypes in Huntington disease mouse neural stem cells. Molecular and Cellular Neurosciences. 50: 70-81. PMID 22508027 DOI: 10.1016/J.Mcn.2012.03.011  0.384
2012 Hickey MA, Zhu C, Medvedeva V, Lerner RP, Patassini S, Franich NR, Maiti P, Frautschy SA, Zeitlin S, Levine MS, Chesselet MF. Improvement of neuropathology and transcriptional deficits in CAG 140 knock-in mice supports a beneficial effect of dietary curcumin in Huntington's disease. Molecular Neurodegeneration. 7: 12. PMID 22475209 DOI: 10.1186/1750-1326-7-12  0.562
2012 Lo Sardo V, Zuccato C, Gaudenzi G, Vitali B, Ramos C, Tartari M, Myre MA, Walker JA, Pistocchi A, Conti L, Valenza M, Drung B, Schmidt B, Gusella J, Zeitlin S, et al. An evolutionary recent neuroepithelial cell adhesion function of huntingtin implicates ADAM10-Ncadherin. Nature Neuroscience. 15: 713-21. PMID 22466506 DOI: 10.1038/Nn.3080  0.46
2011 Liu JP, Zeitlin SO. The long and the short of aberrant ciliogenesis in Huntington disease. The Journal of Clinical Investigation. 121: 4237-41. PMID 21985782 DOI: 10.1172/JCI60243  0.428
2010 Zheng S, Clabough EB, Sarkar S, Futter M, Rubinsztein DC, Zeitlin SO. Deletion of the huntingtin polyglutamine stretch enhances neuronal autophagy and longevity in mice. Plos Genetics. 6: e1000838. PMID 20140187 DOI: 10.1371/journal.pgen.1000838  0.712
2009 Thompson LM, Aiken CT, Kaltenbach LS, Agrawal N, Illes K, Khoshnan A, Martinez-Vincente M, Arrasate M, O'Rourke JG, Khashwji H, Lukacsovich T, Zhu YZ, Lau AL, Massey A, Hayden MR, ... Zeitlin SO, et al. IKK phosphorylates Huntingtin and targets it for degradation by the proteasome and lysosome. The Journal of Cell Biology. 187: 1083-99. PMID 20026656 DOI: 10.1083/Jcb.200909067  0.369
2009 Weiss A, Abramowski D, Bibel M, Bodner R, Chopra V, DiFiglia M, Fox J, Kegel K, Klein C, Grueninger S, Hersch S, Housman D, Régulier E, Rosas HD, Stefani M, ... Zeitlin S, et al. Single-step detection of mutant huntingtin in animal and human tissues: a bioassay for Huntington's disease. Analytical Biochemistry. 395: 8-15. PMID 19664996 DOI: 10.1016/J.Ab.2009.08.001  0.492
2008 Li X, Sapp E, Valencia A, Kegel KB, Qin ZH, Alexander J, Masso N, Reeves P, Ritch JJ, Zeitlin S, Aronin N, Difiglia M. A function of huntingtin in guanine nucleotide exchange on Rab11. Neuroreport. 19: 1643-7. PMID 18845944 DOI: 10.1097/Wnr.0B013E328315Cd4C  0.382
2008 Hickey MA, Kosmalska A, Enayati J, Cohen R, Zeitlin S, Levine MS, Chesselet MF. Extensive early motor and non-motor behavioral deficits are followed by striatal neuronal loss in knock-in Huntington's disease mice. Neuroscience. 157: 280-95. PMID 18805465 DOI: 10.1016/J.Neuroscience.2008.08.041  0.558
2008 Zhang H, Das S, Li QZ, Dragatsis I, Repa J, Zeitlin S, Hajnóczky G, Bezprozvanny I. Elucidating a normal function of huntingtin by functional and microarray analysis of huntingtin-null mouse embryonic fibroblasts. Bmc Neuroscience. 9: 38. PMID 18412970 DOI: 10.1186/1471-2202-9-38  0.614
2007 Zuccato C, Belyaev N, Conforti P, Ooi L, Tartari M, Papadimou E, MacDonald M, Fossale E, Zeitlin S, Buckley N, Cattaneo E. Widespread disruption of repressor element-1 silencing transcription factor/neuron-restrictive silencer factor occupancy at its target genes in Huntington's disease. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 6972-83. PMID 17596446 DOI: 10.1523/Jneurosci.4278-06.2007  0.474
2006 Ryan AB, Zeitlin SO, Scrable H. Genetic interaction between expanded murine Hdh alleles and p53 reveal deleterious effects of p53 on Huntington's disease pathogenesis. Neurobiology of Disease. 24: 419-27. PMID 16978870 DOI: 10.1016/J.Nbd.2006.08.002  0.404
2006 Clabough EB, Zeitlin SO. Deletion of the triplet repeat encoding polyglutamine within the mouse Huntington's disease gene results in subtle behavioral/motor phenotypes in vivo and elevated levels of ATP with cellular senescence in vitro. Human Molecular Genetics. 15: 607-23. PMID 16403806 DOI: 10.1093/hmg/ddi477  0.718
2005 Helton R, Cui J, Scheel JR, Ellison JA, Ames C, Gibson C, Blouw B, Ouyang L, Dragatsis I, Zeitlin S, Johnson RS, Lipton SA, Barlow C. Brain-specific knock-out of hypoxia-inducible factor-1alpha reduces rather than increases hypoxic-ischemic damage. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 4099-107. PMID 15843612 DOI: 10.1523/Jneurosci.4555-04.2005  0.337
2004 Dragatsis I, Zeitlin S, Dietrich P. Huntingtin-associated protein 1 (Hap1) mutant mice bypassing the early postnatal lethality are neuroanatomically normal and fertile but display growth retardation. Human Molecular Genetics. 13: 3115-25. PMID 15496430 DOI: 10.1093/Hmg/Ddh328  0.503
2004 Trushina E, Dyer RB, Badger JD, Ure D, Eide L, Tran DD, Vrieze BT, Legendre-Guillemin V, McPherson PS, Mandavilli BS, Van Houten B, Zeitlin S, McNiven M, Aebersold R, Hayden M, et al. Mutant huntingtin impairs axonal trafficking in mammalian neurons in vivo and in vitro. Molecular and Cellular Biology. 24: 8195-209. PMID 15340079 DOI: 10.1128/Mcb.24.18.8195-8209.2004  0.407
2003 Reiner A, Dragatsis I, Zeitlin S, Goldowitz D. Wild-type huntingtin plays a role in brain development and neuronal survival. Molecular Neurobiology. 28: 259-76. PMID 14709789 DOI: 10.1385/Mn:28:3:259  0.578
2003 Menalled LB, Sison JD, Dragatsis I, Zeitlin S, Chesselet MF. Time course of early motor and neuropathological anomalies in a knock-in mouse model of Huntington's disease with 140 CAG repeats. The Journal of Comparative Neurology. 465: 11-26. PMID 12926013 DOI: 10.1002/Cne.10776  0.485
2002 Menalled LB, Sison JD, Wu Y, Olivieri M, Li XJ, Li H, Zeitlin S, Chesselet MF. Early motor dysfunction and striosomal distribution of huntingtin microaggregates in Huntington's disease knock-in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 8266-76. PMID 12223581 DOI: 10.1523/Jneurosci.22-18-08266.2002  0.517
2001 Reiner A, Del Mar N, Meade CA, Yang H, Dragatsis I, Zeitlin S, Goldowitz D. Neurons lacking huntingtin differentially colonize brain and survive in chimeric mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 7608-19. PMID 11567051 DOI: 10.1523/Jneurosci.21-19-07608.2001  0.456
2001 Dragatsis I, Zeitlin S. A method for the generation of conditional gene repair mutations in mice. Nucleic Acids Research. 29. PMID 11160912 DOI: 10.1093/Nar/29.3.E10  0.457
2000 Dragatsis I, Levine MS, Zeitlin S. Inactivation of Hdh in the brain and testis results in progressive neurodegeneration and sterility in mice. Nature Genetics. 26: 300-6. PMID 11062468 DOI: 10.1038/81593  0.529
2000 Menalled L, Zanjani H, MacKenzie L, Koppel A, Carpenter E, Zeitlin S, Chesselet MF. Decrease in striatal enkephalin mRNA in mouse models of Huntington's disease. Experimental Neurology. 162: 328-42. PMID 10739639 DOI: 10.1006/Exnr.1999.7327  0.535
2000 Dietrich P, Dragatsis I, Xuan S, Zeitlin S, Efstratiadis A. Conditional mutagenesis in mice with heat shock promoter-driven cre transgenes. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 11: 196-205. PMID 10723724 DOI: 10.1007/S003350010037  0.466
2000 Dragatsis I, Dietrich P, Zeitlin S. Expression of the Huntingtin-associated protein 1 gene in the developing and adult mouse. Neuroscience Letters. 282: 37-40. PMID 10713390 DOI: 10.1016/S0304-3940(00)00872-7  0.425
2000 Dragatsis I, Zeitlin S. CaMKIIα-cre transgene expression and recombination patterns in the mouse brain Genesis. 26: 133-135. PMID 10686608 DOI: 10.1002/(Sici)1526-968X(200002)26:2<133::Aid-Gene10>3.0.Co;2-V  0.363
2000 Metzler M, Helgason CD, Dragatsis I, Zhang T, Gan L, Pineault N, Zeitlin SO, Humphries RK, Hayden MR. Huntingtin is required for normal hematopoiesis. Human Molecular Genetics. 9: 387-94. PMID 10655548 DOI: 10.1093/Hmg/9.3.387  0.389
1999 Levine MS, Klapstein GJ, Koppel A, Gruen E, Cepeda C, Vargas ME, Jokel ES, Carpenter EM, Zanjani H, Hurst RS, Efstratiadis A, Zeitlin S, Chesselet MF. Enhanced sensitivity to N-methyl-D-aspartate receptor activation in transgenic and knockin mouse models of Huntington's disease. Journal of Neuroscience Research. 58: 515-32. PMID 10533044 DOI: 10.1002/(Sici)1097-4547(19991115)58:4<515::Aid-Jnr5>3.0.Co;2-F  0.442
1999 Buiakova OI, Xu J, Lutsenko S, Zeitlin S, Das K, Das S, Ross BM, Mekios C, Scheinberg IH, Gilliam TC. Null mutation of the murine ATP7B (Wilson disease) gene results in intracellular copper accumulation and late-onset hepatic nodular transformation. Human Molecular Genetics. 8: 1665-71. PMID 10441329 DOI: 10.1093/Hmg/8.9.1665  0.45
1995 Zeitlin S, Liu JP, Chapman DL, Papaioannou VE, Efstratiadis A. Increased apoptosis and early embryonic lethality in mice nullizygous for the Huntington's disease gene homologue. Nature Genetics. 11: 155-63. PMID 7550343 DOI: 10.1038/Ng1095-155  0.562
1986 Soares MB, Turken A, Ishii D, Mills L, Episkopou V, Cotter S, Zeitlin S, Efstratiadis A. Rat insulin-like growth factor II gene. A single gene with two promoters expressing a multitranscript family. Journal of Molecular Biology. 192: 737-52. PMID 2438416 DOI: 10.1016/0022-2836(86)90025-2  0.322
1985 Soares MB, Schon E, Henderson A, Karathanasis SK, Cate R, Zeitlin S, Chirgwin J, Efstratiadis A. RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Molecular and Cellular Biology. 5: 2090-103. PMID 2427930 DOI: 10.1128/Mcb.5.8.2090  0.416
1984 Chan SJ, Episkopou V, Zeitlin S, Karathanasis SK, MacKrell A, Steiner DF, Efstratiadis A. Guinea pig preproinsulin gene: an evolutionary compromise? Proceedings of the National Academy of Sciences of the United States of America. 81: 5046-50. PMID 6591179 DOI: 10.1073/Pnas.81.16.5046  0.348
Show low-probability matches.