Jeffrey N. Savas - Publications

Affiliations: 
2015- Neurology Northwestern University, Evanston, IL 

40 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kim JJ, Savas JN, Miller MT, Hu X, Carromeu C, Lavallée-Adam M, Freitas BCG, Muotri AR, Yates JR, Ghosh A. Proteomic analyses reveal misregulation of LIN28 expression and delayed timing of glial differentiation in human iPS cells with MECP2 loss-of-function. Plos One. 14: e0212553. PMID 30789962 DOI: 10.1371/journal.pone.0212553  0.4
2018 Wortham M, Benthuysen JR, Wallace M, Savas JN, Mulas F, Divakaruni AS, Liu F, Albert V, Taylor BL, Sui Y, Saez E, Murphy AN, Yates JR, Metallo CM, Sander M. Integrated In Vivo Quantitative Proteomics and Nutrient Tracing Reveals Age-Related Metabolic Rewiring of Pancreatic β Cell Function. Cell Reports. 25: 2904-2918.e8. PMID 30517875 DOI: 10.1016/j.celrep.2018.11.031  0.4
2018 Liu P, Thomson BR, Khalatyan N, Feng L, Liu X, Savas JN, Quaggin SE, Jin J. Selective permeability of mouse blood-aqueous barrier as determined by N-heavy isotope tracing and mass spectrometry. Proceedings of the National Academy of Sciences of the United States of America. PMID 30127000 DOI: 10.1073/pnas.1807982115  0.32
2018 Wang YZ, Savas JN. Uncovering Discrete Synaptic Proteomes to Understand Neurological Disorders. Proteomes. 6. PMID 30029459 DOI: 10.3390/proteomes6030030  0.96
2017 Savas JN, Wang YZ, DeNardo LA, Martinez-Bartolome S, McClatchy DB, Hark TJ, Shanks NF, Cozzolino KA, Lavallée-Adam M, Smukowski SN, Park SK, Kelly JW, Koo EH, Nakagawa T, Masliah E, et al. Amyloid Accumulation Drives Proteome-wide Alterations in Mouse Models of Alzheimer's Disease-like Pathology. Cell Reports. 21: 2614-2627. PMID 29186695 DOI: 10.1016/j.celrep.2017.11.009  0.96
2017 Burbulla LF, Song P, Mazzulli JR, Zampese E, Wong YC, Jeon S, Santos DP, Blanz J, Obermaier CD, Strojny C, Savas JN, Kiskinis E, Zhuang X, Krüger R, Surmeier DJ, et al. Dopamine oxidation mediates mitochondrial and lysosomal dysfunction in Parkinson's disease. Science (New York, N.Y.). PMID 28882997 DOI: 10.1126/science.aam9080  0.56
2017 Widjaja CE, Olvera JG, Metz PJ, Phan AT, Savas JN, de Bruin G, Leestemaker Y, Berkers CR, de Jong A, Florea BI, Fisch K, Lopez J, Kim SH, Garcia DA, Searles S, et al. Proteasome activity regulates CD8+ T lymphocyte metabolism and fate specification. The Journal of Clinical Investigation. PMID 28846070 DOI: 10.1172/JCI90895  0.4
2016 Hickox AE, Wong AC, Pak K, Strojny C, Ramirez M, Yates JR, Ryan AF, Savas JN. Global Analysis of Protein Expression of Inner Ear Hair Cells. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. PMID 28039372 DOI: 10.1523/JNEUROSCI.2267-16.2016  0.4
2016 Mita P, Savas JN, Briggs EM, Ha S, Gnanakkan V, Yates JR, Robins DM, David G, Boeke JD, Garabedian MJ, Logan SK. URI Regulates KAP1 Phosphorylation and Transcriptional Repression Via PP2A Phosphatase in Prostate Cancer Cells. The Journal of Biological Chemistry. PMID 27780869 DOI: 10.1074/jbc.M116.741660  0.4
2016 Yonashiro R, Tahara EB, Bengtson MH, Khokhrina M, Lorenz H, Chen KC, Kigoshi-Tansho Y, Savas JN, Yates JR, Kay SA, Craig EA, Mogk A, Bukau B, Joazeiro CA. The Rqc2/Tae2 subunit of the ribosome-associated quality control (RQC) complex marks ribosome-stalled nascent polypeptide chains for aggregation. Elife. 5. PMID 26943317 DOI: 10.7554/eLife.11794  0.4
2016 Savas JN, Park SK, Yates JR. Proteomic Analysis of Protein Turnover by Metabolic Whole Rodent Pulse-Chase Isotopic Labeling and Shotgun Mass Spectrometry Analysis. Methods in Molecular Biology (Clifton, N.J.). 1410: 293-304. PMID 26867752 DOI: 10.1007/978-1-4939-3524-6_18  0.4
2015 Savas JN, Ribeiro LF, Wierda KD, Wright R, DeNardo-Wilke LA, Rice HC, Chamma I, Wang YZ, Zemla R, Lavallée-Adam M, Vennekens KM, O'Sullivan ML, Antonios JK, Hall EA, Thoumine O, et al. The Sorting Receptor SorCS1 Regulates Trafficking of Neurexin and AMPA Receptors. Neuron. 87: 764-80. PMID 26291160 DOI: 10.1016/j.neuron.2015.08.007  0.96
2015 McClatchy DB, Savas JN, Martínez-Bartolomé S, Park SK, Maher P, Powell SB, Yates JR. Global quantitative analysis of phosphorylation underlying phencyclidine signaling and sensorimotor gating in the prefrontal cortex. Molecular Psychiatry. PMID 25869802 DOI: 10.1038/mp.2015.41  0.4
2015 Brennand K, Savas JN, Kim Y, Tran N, Simone A, Hashimoto-Torii K, Beaumont KG, Kim HJ, Topol A, Ladran I, Abdelrahim M, Matikainen-Ankney B, Chao SH, Mrksich M, Rakic P, et al. Phenotypic differences in hiPSC NPCs derived from patients with schizophrenia. Molecular Psychiatry. 20: 361-8. PMID 24686136 DOI: 10.1038/mp.2014.22  1
2014 Savas JN, De Wit J, Comoletti D, Zemla R, Ghosh A, Yates JR. Ecto-Fc MS identifies ligand-receptor interactions through extracellular domain Fc fusion protein baits and shotgun proteomic analysis. Nature Protocols. 9: 2061-74. PMID 25101821 DOI: 10.1038/nprot.2014.140  1
2014 Karttunen H, Savas JN, McKinney C, Chen YH, Yates JR, Hukkanen V, Huang TT, Mohr I. Co-opting the Fanconi anemia genomic stability pathway enables herpesvirus DNA synthesis and productive growth. Molecular Cell. 55: 111-22. PMID 24954902 DOI: 10.1016/j.molcel.2014.05.020  1
2014 Lee GH, Chhangawala Z, von Daake S, Savas JN, Yates JR, Comoletti D, D'Arcangelo G. Reelin induces Erk1/2 signaling in cortical neurons through a non-canonical pathway. The Journal of Biological Chemistry. 289: 20307-17. PMID 24876378 DOI: 10.1074/jbc.M114.576249  1
2013 Parkhurst CN, Yang G, Ninan I, Savas JN, Yates JR, Lafaille JJ, Hempstead BL, Littman DR, Gan WB. Microglia promote learning-dependent synapse formation through brain-derived neurotrophic factor. Cell. 155: 1596-609. PMID 24360280 DOI: 10.1016/j.cell.2013.11.030  1
2013 Wan J, Savas JN, Roth AF, Sanders SS, Singaraja RR, Hayden MR, Yates JR, Davis NG. Tracking brain palmitoylation change: predominance of glial change in a mouse model of Huntington's disease. Chemistry & Biology. 20: 1421-34. PMID 24211138 DOI: 10.1016/j.chembiol.2013.09.018  1
2013 Toyama BH, Savas JN, Park SK, Harris MS, Ingolia NT, Yates JR, Hetzer MW. Identification of long-lived proteins reveals exceptional stability of essential cellular structures. Cell. 154: 971-82. PMID 23993091 DOI: 10.1016/j.cell.2013.07.037  1
2013 de Wit J, O'Sullivan ML, Savas JN, Condomitti G, Caccese MC, Vennekens KM, Yates JR, Ghosh A. Unbiased discovery of glypican as a receptor for LRRTM4 in regulating excitatory synapse development. Neuron. 79: 696-711. PMID 23911103 DOI: 10.1016/j.neuron.2013.06.049  1
2013 Mita P, Savas JN, Ha S, Djouder N, Yates JR, Logan SK. Analysis of URI nuclear interaction with RPB5 and components of the R2TP/prefoldin-like complex. Plos One. 8: e63879. PMID 23667685 DOI: 10.1371/journal.pone.0063879  1
2013 Butko MT, Savas JN, Friedman B, Delahunty C, Ebner F, Yates JR, Tsien RY. In vivo quantitative proteomics of somatosensory cortical synapses shows which protein levels are modulated by sensory deprivation. Proceedings of the National Academy of Sciences of the United States of America. 110: E726-35. PMID 23382246 DOI: 10.1073/pnas.1300424110  1
2012 Shanks NF, Savas JN, Maruo T, Cais O, Hirao A, Oe S, Ghosh A, Noda Y, Greger IH, Yates JR, Nakagawa T. Differences in AMPA and kainate receptor interactomes facilitate identification of AMPA receptor auxiliary subunit GSG1L. Cell Reports. 1: 590-8. PMID 22813734 DOI: 10.1016/j.celrep.2012.05.004  1
2012 Ma B, Savas JN, Chao MV, Tanese N. Quantitative analysis of BDNF/TrkB protein and mRNA in cortical and striatal neurons using α-tubulin as a normalization factor. Cytometry. Part a : the Journal of the International Society For Analytical Cytology. 81: 704-17. PMID 22649026 DOI: 10.1002/cyto.a.22073  1
2012 Culver BP, Savas JN, Park SK, Choi JH, Zheng S, Zeitlin SO, Yates JR, Tanese N. Proteomic analysis of wild-type and mutant huntingtin-associated proteins in mouse brains identifies unique interactions and involvement in protein synthesis. The Journal of Biological Chemistry. 287: 21599-614. PMID 22556411 DOI: 10.1074/jbc.M112.359307  1
2012 Yates JR, Park SK, Delahunty CM, Xu T, Savas JN, Cociorva D, Carvalho PC. Toward objective evaluation of proteomic algorithms. Nature Methods. 9: 455-6. PMID 22543378 DOI: 10.1038/nmeth.1983  1
2012 O'Sullivan ML, de Wit J, Savas JN, Comoletti D, Otto-Hitt S, Yates JR, Ghosh A. FLRT proteins are endogenous latrophilin ligands and regulate excitatory synapse development. Neuron. 73: 903-10. PMID 22405201 DOI: 10.1016/j.neuron.2012.01.018  1
2012 Savas JN, Toyama BH, Xu T, Yates JR, Hetzer MW. Extremely long-lived nuclear pore proteins in the rat brain. Science (New York, N.Y.). 335: 942. PMID 22300851 DOI: 10.1126/science.1217421  1
2012 Jeong H, Cohen DE, Cui L, Supinski A, Savas JN, Mazzulli JR, Yates JR, Bordone L, Guarente L, Krainc D. Sirt1 mediates neuroprotection from mutant huntingtin by activation of the TORC1 and CREB transcriptional pathway. Nature Medicine. 18: 159-65. PMID 22179316 DOI: 10.1038/nm.2559  1
2011 Ma B, Savas JN, Yu MS, Culver BP, Chao MV, Tanese N. Huntingtin mediates dendritic transport of β-actin mRNA in rat neurons. Scientific Reports. 1: 140. PMID 22355657 DOI: 10.1038/srep00140  1
2011 Mita P, Savas JN, Djouder N, Yates JR, Ha S, Ruoff R, Schafler ED, Nwachukwu JC, Tanese N, Cowan NJ, Zavadil J, Garabedian MJ, Logan SK. Regulation of androgen receptor-mediated transcription by RPB5 binding protein URI/RMP. Molecular and Cellular Biology. 31: 3639-52. PMID 21730289 DOI: 10.1128/MCB.05429-11  1
2011 Savas JN, Stein BD, Wu CC, Yates JR. Mass spectrometry accelerates membrane protein analysis. Trends in Biochemical Sciences. 36: 388-96. PMID 21616670 DOI: 10.1016/j.tibs.2011.04.005  1
2010 Pham E, Crews L, Ubhi K, Hansen L, Adame A, Cartier A, Salmon D, Galasko D, Michael S, Savas JN, Yates JR, Glabe C, Masliah E. Progressive accumulation of amyloid-beta oligomers in Alzheimer's disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins. The Febs Journal. 277: 3051-67. PMID 20573181 DOI: 10.1111/j.1742-4658.2010.07719.x  1
2010 Savas JN, Ma B, Deinhardt K, Culver BP, Restituito S, Wu L, Belasco JG, Chao MV, Tanese N. A role for huntington disease protein in dendritic RNA granules. The Journal of Biological Chemistry. 285: 13142-53. PMID 20185826 DOI: 10.1074/jbc.M110.114561  1
2010 Savas JN, Tanese N. A combined immunoprecipitation, mass spectrometric and nucleic acid sequencing approach to determine microRNA-mediated post-transcriptional gene regulatory networks. Briefings in Functional Genomics. 9: 24-31. PMID 20053813 DOI: 10.1093/bfgp/elp050  1
2009 de Wit J, Sylwestrak E, O'Sullivan ML, Otto S, Tiglio K, Savas JN, Yates JR, Comoletti D, Taylor P, Ghosh A. LRRTM2 interacts with Neurexin1 and regulates excitatory synapse formation. Neuron. 64: 799-806. PMID 20064388 DOI: 10.1016/j.neuron.2009.12.019  1
2009 Jeong H, Then F, Melia TJ, Mazzulli JR, Cui L, Savas JN, Voisine C, Paganetti P, Tanese N, Hart AC, Yamamoto A, Krainc D. Acetylation targets mutant huntingtin to autophagosomes for degradation. Cell. 137: 60-72. PMID 19345187 DOI: 10.1016/j.cell.2009.03.018  1
2008 Savas JN, Makusky A, Ottosen S, Baillat D, Then F, Krainc D, Shiekhattar R, Markey SP, Tanese N. Huntington's disease protein contributes to RNA-mediated gene silencing through association with Argonaute and P bodies. Proceedings of the National Academy of Sciences of the United States of America. 105: 10820-5. PMID 18669659 DOI: 10.1073/pnas.0800658105  1
2007 Williams E, Lowe TM, Savas J, DiRuggiero J. Microarray analysis of the hyperthermophilic archaeon Pyrococcus furiosus exposed to gamma irradiation. Extremophiles : Life Under Extreme Conditions. 11: 19-29. PMID 16896524 DOI: 10.1007/s00792-006-0002-9  1
Show low-probability matches.