Randy Hampton - Publications

Affiliations: 
University of California, San Diego, La Jolla, CA 
Area:
Biochemistry, Cell Biology, Molecular Biology

56 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Flagg MP, Wangeline MA, Holland SR, Duttke SH, Benner C, Neal S, Hampton RY. Inner-Nuclear-Membrane-Associated Degradation Employs Dfm1-Independent Retrotranslocation and Alleviates Misfolded Transmembrane-Protein Toxicity. Molecular Biology of the Cell. mbcE20110720. PMID 33566711 DOI: 10.1091/mbc.E20-11-0720  0.757
2020 Wangeline MA, Hampton RY. An autonomous, but INSIG-modulated, role for the Sterol Sensing Domain in mallostery-regulated ERAD of yeast HMG-CoA reductase. The Journal of Biological Chemistry. PMID 33184059 DOI: 10.1074/jbc.RA120.015910  0.401
2020 Singh A, Vashistha N, Heck J, Tang X, Wipf P, Brodsky JL, Hampton RY. Direct involvement of Hsp70 ATP hydrolysis in Ubr1-dependent quality control. Molecular Biology of the Cell. mbcE20080541. PMID 32966159 DOI: 10.1091/mbc.E20-08-0541  0.403
2020 Neal S, Syau D, Nejatfard A, Nadeau S, Hampton RY. HRD Complex Self-Remodeling Enables a Novel Route of Membrane Protein Retrotranslocation. Iscience. 23: 101493. PMID 32891886 DOI: 10.1016/J.Isci.2020.101493  0.758
2019 Neal S, Duttke SH, Hampton RY. Assays for protein retrotranslocation in ERAD. Methods in Enzymology. 619: 1-26. PMID 30910017 DOI: 10.1016/Bs.Mie.2019.01.002  0.75
2019 Wangeline M, Hampton R. Mallostery: Ligand‐dependent Misfolding as a Strategy for Protein Regulation The Faseb Journal. 33. DOI: 10.1096/fasebj.2019.33.1_supplement.351.3  0.367
2018 Wangeline MA, Hampton RY. "Mallostery"-ligand-dependent protein misfolding enables physiological regulation by ERAD. The Journal of Biological Chemistry. PMID 30018140 DOI: 10.1074/Jbc.Ra118.001808  0.411
2018 Neal S, Jaeger PA, Duttke SH, Benner C, Glass CK, Ideker T, Hampton RY. The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins. Molecular Cell. 69: 915. PMID 29499140 DOI: 10.1016/j.molcel.2018.02.014  0.712
2018 Neal S, Jaeger PA, Duttke SH, Benner CK, Glass C, Ideker T, Hampton R. The Dfm1 Derlin Is Required for ERAD Retrotranslocation of Integral Membrane Proteins. Molecular Cell. 69: 306-320.e4. PMID 29351849 DOI: 10.1016/J.Molcel.2017.12.012  0.761
2017 Wangeline MA, Vashistha N, Hampton RY. Proteostatic Tactics in the Strategy of Sterol Regulation. Annual Review of Cell and Developmental Biology. 33: 467-489. PMID 28992438 DOI: 10.1146/Annurev-Cellbio-111315-125036  0.384
2017 Hampton RY, Dargemont C. New developments for protein quality control. Science (New York, N.Y.). 357: 450-451. PMID 28774913 DOI: 10.1126/Science.Aao1896  0.348
2017 Neal SE, Mak R, Bennett EJ, Hampton R. A "Retrochaperone" Function for Cdc48: the Cdc48 Complex is Required for Retrotranslocated ERAD-M Substrate Solubility. The Journal of Biological Chemistry. PMID 28077573 DOI: 10.1074/Jbc.M116.770610  0.728
2016 Vashistha N, Neal SE, Singh A, Carroll SM, Hampton RY. Direct and essential function for Hrd3 in ER-associated degradation. Proceedings of the National Academy of Sciences of the United States of America. PMID 27170191 DOI: 10.1073/Pnas.1603079113  0.724
2015 Higgins R, Gendron JM, Rising L, Mak R, Webb K, Kaiser SE, Zuzow N, Riviere P, Yang B, Fenech E, Tang X, Lindsay SA, Christianson JC, Hampton RY, Wasserman SA, et al. The Unfolded Protein Response Triggers Site-Specific Regulatory Ubiquitylation of 40S Ribosomal Proteins. Molecular Cell. 59: 35-49. PMID 26051182 DOI: 10.1016/J.Molcel.2015.04.026  0.444
2013 Theesfeld CL, Hampton RY. Insulin-induced gene protein (INSIG)-dependent sterol regulation of Hmg2 endoplasmic reticulum-associated degradation (ERAD) in yeast. The Journal of Biological Chemistry. 288: 8519-30. PMID 23306196 DOI: 10.1074/Jbc.M112.404517  0.376
2012 Hampton RY, Sommer T. Finding the will and the way of ERAD substrate retrotranslocation. Current Opinion in Cell Biology. 24: 460-6. PMID 22854296 DOI: 10.1016/J.Ceb.2012.05.010  0.529
2011 Theesfeld CL, Pourmand D, Davis T, Garza RM, Hampton RY. The sterol-sensing domain (SSD) directly mediates signal-regulated endoplasmic reticulum-associated degradation (ERAD) of 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase isozyme Hmg2. The Journal of Biological Chemistry. 286: 26298-307. PMID 21628456 DOI: 10.1074/Jbc.M111.244798  0.44
2010 Heck JW, Cheung SK, Hampton RY. Cytoplasmic protein quality control degradation mediated by parallel actions of the E3 ubiquitin ligases Ubr1 and San1. Proceedings of the National Academy of Sciences of the United States of America. 107: 1106-11. PMID 20080635 DOI: 10.1073/Pnas.0910591107  0.438
2010 Carroll SM, Hampton RY. Usa1p is required for optimal function and regulation of the Hrd1p endoplasmic reticulum-associated degradation ubiquitin ligase. The Journal of Biological Chemistry. 285: 5146-56. PMID 19940128 DOI: 10.1074/Jbc.M109.067876  0.527
2009 Garza RM, Tran PN, Hampton RY. Geranylgeranyl pyrophosphate is a potent regulator of HRD-dependent 3-Hydroxy-3-methylglutaryl-CoA reductase degradation in yeast. The Journal of Biological Chemistry. 284: 35368-80. PMID 19776008 DOI: 10.1074/Jbc.M109.023994  0.314
2009 Sato BK, Schulz D, Do PH, Hampton RY. Misfolded membrane proteins are specifically recognized by the transmembrane domain of the Hrd1p ubiquitin ligase. Molecular Cell. 34: 212-22. PMID 19394298 DOI: 10.1016/J.Molcel.2009.03.010  0.518
2009 Garza RM, Sato BK, Hampton RY. In vitro analysis of Hrd1p-mediated retrotranslocation of its multispanning membrane substrate 3-hydroxy-3-methylglutaryl (HMG)-CoA reductase. The Journal of Biological Chemistry. 284: 14710-22. PMID 19324879 DOI: 10.1074/Jbc.M809607200  0.543
2009 Hampton RY, Garza RM. Protein quality control as a strategy for cellular regulation: lessons from ubiquitin-mediated regulation of the sterol pathway. Chemical Reviews. 109: 1561-74. PMID 19243134 DOI: 10.1021/Cr800544V  0.437
2009 Hampton RY, Garza RM. ChemInform Abstract: Protein Quality Control as a Strategy for Cellular Regulation: Lessons from Ubiquitin-Mediated Regulation of the Serol Pathway Cheminform. 40. DOI: 10.1002/CHIN.200926269  0.331
2008 Federovitch CM, Jones YZ, Tong AH, Boone C, Prinz WA, Hampton RY. Genetic and structural analysis of Hmg2p-induced endoplasmic reticulum remodeling in Saccharomyces cerevisiae. Molecular Biology of the Cell. 19: 4506-20. PMID 18667535 DOI: 10.1091/Mbc.E07-11-1188  0.458
2008 Bazirgan OA, Hampton RY. Cue1p is an activator of Ubc7p E2 activity in vitro and in vivo. The Journal of Biological Chemistry. 283: 12797-810. PMID 18321851 DOI: 10.1074/Jbc.M801122200  0.355
2007 Chen D, Gould C, Garza R, Gao T, Hampton RY, Newton AC. Amplitude control of protein kinase C by RINCK, a novel E3 ubiquitin ligase. The Journal of Biological Chemistry. 282: 33776-87. PMID 17893151 DOI: 10.1074/Jbc.M703320200  0.317
2006 Sato BK, Hampton RY. Yeast Derlin Dfm1 interacts with Cdc48 and functions in ER homeostasis. Yeast (Chichester, England). 23: 1053-64. PMID 17083136 DOI: 10.1002/Yea.1407  0.356
2006 Bazirgan OA, Garza RM, Hampton RY. Determinants of RING-E2 fidelity for Hrd1p, a membrane-anchored ubiquitin ligase. The Journal of Biological Chemistry. 281: 38989-9001. PMID 17035235 DOI: 10.1074/Jbc.M608174200  0.351
2005 Hampton RY. Fusion-based strategies to identify genes involved in degradation of a specific substrate. Methods in Enzymology. 399: 310-23. PMID 16338365 DOI: 10.1016/S0076-6879(05)99021-6  0.307
2005 Flury I, Garza R, Shearer A, Rosen J, Cronin S, Hampton RY. INSIG: a broadly conserved transmembrane chaperone for sterol-sensing domain proteins. The Embo Journal. 24: 3917-26. PMID 16270032 DOI: 10.1038/Sj.Emboj.7600855  0.455
2005 Shearer AG, Hampton RY. Lipid-mediated, reversible misfolding of a sterol-sensing domain protein. The Embo Journal. 24: 149-59. PMID 15635451 DOI: 10.1038/Sj.Emboj.7600498  0.336
2004 Baumeister W, Bachmair A, Chau V, Cohen R, Coffino P, Demartino G, Deshaies R, Dohmen J, Emr S, Finley D, Hampton R, Hill C, Hochstrasser M, Huber R, Jackson P, et al. Varshavsky's contributions. Science (New York, N.Y.). 306: 1290-2. PMID 15550643 DOI: 10.1126/Science.306.5700.1290  0.391
2004 Ron D, Hampton RY. Membrane biogenesis and the unfolded protein response. The Journal of Cell Biology. 167: 23-5. PMID 15479733 DOI: 10.1083/Jcb.200408117  0.492
2004 Shearer AG, Hampton RY. Structural control of endoplasmic reticulum-associated degradation: effect of chemical chaperones on 3-hydroxy-3-methylglutaryl-CoA reductase. The Journal of Biological Chemistry. 279: 188-96. PMID 14570925 DOI: 10.1074/Jbc.M307734200  0.431
2003 Hampton RY. IRE1: a role in UPREgulation of ER degradation. Developmental Cell. 4: 144-6. PMID 12586055 DOI: 10.1016/S1534-5807(03)00032-7  0.386
2002 Hampton RY. ER-associated degradation in protein quality control and cellular regulation. Current Opinion in Cell Biology. 14: 476-82. PMID 12383799 DOI: 10.1016/S0955-0674(02)00358-7  0.451
2002 Hampton RY. Proteolysis and sterol regulation. Annual Review of Cell and Developmental Biology. 18: 345-78. PMID 12142284 DOI: 10.1146/Annurev.Cellbio.18.032002.131219  0.341
2002 Cronin SR, Rao R, Hampton RY. Cod1p/Spf1p is a P-type ATPase involved in ER function and Ca2+ homeostasis. The Journal of Cell Biology. 157: 1017-28. PMID 12058017 DOI: 10.1083/Jcb.200203052  0.37
2002 Bays NW, Hampton RY. Cdc48-Ufd1-Npl4: stuck in the middle with Ub. Current Biology : Cb. 12: R366-71. PMID 12015140 DOI: 10.1016/S0960-9822(02)00862-X  0.471
2001 Bays NW, Wilhovsky SK, Goradia A, Hodgkiss-Harlow K, Hampton RY. HRD4/NPL4 is required for the proteasomal processing of ubiquitinated ER proteins. Molecular Biology of the Cell. 12: 4114-28. PMID 11739805 DOI: 10.1091/Mbc.12.12.4114  0.445
2001 Gardner RG, Shearer AG, Hampton RY. In vivo action of the HRD ubiquitin ligase complex: mechanisms of endoplasmic reticulum quality control and sterol regulation. Molecular and Cellular Biology. 21: 4276-91. PMID 11390656 DOI: 10.1128/Mcb.21.13.4276-4291.2001  0.467
2001 Bays NW, Gardner RG, Seelig LP, Joazeiro CA, Hampton RY. Hrd1p/Der3p is a membrane-anchored ubiquitin ligase required for ER-associated degradation. Nature Cell Biology. 3: 24-9. PMID 11146622 DOI: 10.1038/35050524  0.52
2000 Gardner RG, Swarbrick GM, Bays NW, Cronin SR, Wilhovsky S, Seelig L, Kim C, Hampton RY. Endoplasmic reticulum degradation requires lumen to cytosol signaling. Transmembrane control of Hrd1p by Hrd3p. The Journal of Cell Biology. 151: 69-82. PMID 11018054 DOI: 10.1083/Jcb.151.1.69  0.458
2000 Hampton RY. ER stress response: Getting the UPR hand on misfolded proteins Current Biology. 10. PMID 10898996 DOI: 10.1016/S0960-9822(00)00583-2  0.423
2000 Wilhovsky S, Gardner R, Hampton R. HRD gene dependence of endoplasmic reticulum-associated degradation. Molecular Biology of the Cell. 11: 1697-708. PMID 10793145 DOI: 10.1091/Mbc.11.5.1697  0.548
2000 Cronin SR, Khoury A, Ferry DK, Hampton RY. Regulation of HMG-CoA reductase degradation requires the P-type ATPase Cod1p/Spf1p. The Journal of Cell Biology. 148: 915-24. PMID 10704442 DOI: 10.1083/Jcb.148.5.915  0.388
1999 Cronin SR, Hampton RY. Measuring protein degradation with green fluorescent protein. Methods in Enzymology. 302: 58-73. PMID 12876763 DOI: 10.1016/S0076-6879(99)02010-8  0.422
1999 Gardner RG, Hampton RY. A 'distributed degron' allows regulated entry into the ER degradation pathway Embo Journal. 18: 5994-6004. PMID 10545111 DOI: 10.1093/Emboj/18.21.5994  0.43
1998 Gardner R, Cronin S, Leader B, Rine J, Hampton R. Sequence Determinants for Regulated Degradation of Yeast 3-Hydroxy-3-Methylglutaryl-CoA Reductase, an Integral Endoplasmic Reticulum Membrane Protein Molecular Biology of the Cell. 9: 2611-2626. PMID 9725915 DOI: 10.1091/Mbc.9.9.2611  0.592
1997 Hampton RY, Bhakta H. Ubiquitin-mediated regulation of 3-hydroxy-3-methylglutaryl-CoA reductase Proceedings of the National Academy of Sciences of the United States of America. 94: 12944-12948. PMID 9371780 DOI: 10.1073/Pnas.94.24.12944  0.376
1996 Hampton RY, Gardner RG, Rine J. Role of 26S proteasome and HRD genes in the degradation of 3-hydroxy-3- methylglutaryl-CoA reductase, an integral endoplasmic reticulum membrane protein Molecular Biology of the Cell. 7: 2029-2044. PMID 8970163 DOI: 10.1091/Mbc.7.12.2029  0.674
1996 Hampton RY, Koning A, Wright R, Rine J. In vivo examination of membrane protein localization and degradation with green fluorescent protein Proceedings of the National Academy of Sciences of the United States of America. 93: 828-833. PMID 8570643 DOI: 10.1073/Pnas.93.2.828  0.646
1996 Hampton R, Dimster-Denk D, Rine J. The biology of HMG-CoA reductase: the pros of contra-regulation Trends in Biochemical Sciences. 21: 140-145. DOI: 10.1016/S0968-0004(96)80168-X  0.542
1994 Hampton RY, Rine J. Regulated degradation of HMG-CoA reductase, an integral membrane protein of the endoplasmic reticulum, in yeast Journal of Cell Biology. 125: 299-312. PMID 8163547 DOI: 10.1083/Jcb.125.2.299  0.681
1990 Golenbock DT, Hampton RY, Raetz CR, Wright SD. Human phagocytes have multiple lipid A-binding sites. Infection and Immunity. 58: 4069-4075. DOI: 10.1128/iai.58.12.4069-4075.1990  0.429
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