| Year |
Citation |
Score |
| 2022 |
Wilhelm P, Luna-Ramirez K, Chin YK, Dekan Z, Abraham N, Tae HS, Chow CY, Eagles DA, King GF, Lewis RJ, Adams DJ, Alewood PF. Cysteine-Rich α-Conotoxin SII Displays Novel Interactions at the Muscle Nicotinic Acetylcholine Receptor. Acs Chemical Neuroscience. PMID 35357806 DOI: 10.1021/acschemneuro.1c00857 |
0.337 |
|
| 2020 |
Herzig V, Sunagar K, Wilson DTR, Pineda SS, Israel MR, Dutertre S, McFarland BS, Undheim EAB, Hodgson WC, Alewood PF, Lewis RJ, Bosmans F, Vetter I, King GF, Fry BG. Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators. Proceedings of the National Academy of Sciences of the United States of America. PMID 32958636 DOI: 10.1073/Pnas.2004516117 |
0.303 |
|
| 2020 |
Cardoso FC, Marliac MA, Geoffroy C, Schmit M, Bispat A, Lewis RJ, Tuck KL, Duggan PJ. The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorganic & Medicinal Chemistry. 28: 115655. PMID 32828422 DOI: 10.1016/J.Bmc.2020.115655 |
0.313 |
|
| 2020 |
Cardoso FC, Castro J, Grundy L, Schober G, Garcia-Caraballo S, Zhao T, Herzig V, King GF, Brierley SM, Lewis RJ. A spider-venom peptide with multi-target activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain. PMID 32826759 DOI: 10.1097/J.Pain.0000000000002041 |
0.334 |
|
| 2020 |
L'Herondelle K, Pierre O, Fouyet S, Leschiera R, Le Gall-Ianotto C, Philippe R, Buscaglia P, Mignen O, Talagas M, Lewis RJ, Michel L, Misery L, Le Garrec R. PAR2, keratinocytes and cathepsin S mediate the sensory effects of ciguatoxins responsible for ciguatera poisoning. The Journal of Investigative Dermatology. PMID 32800876 DOI: 10.1016/J.Jid.2020.07.020 |
0.31 |
|
| 2020 |
Wang D, Himaya SWA, Giacomotto J, Hasan MM, Cardoso FC, Ragnarsson L, Lewis RJ. Characterisation of d-Conotoxin TxVIA as a Mammalian T-Type Calcium Channel Modulator. Marine Drugs. 18. PMID 32629781 DOI: 10.3390/Md18070343 |
0.308 |
|
| 2020 |
Rupasinghe DB, Herzig V, Vetter I, Dekan Z, Gilchrist J, Bosmans F, Alewood PF, Lewis RJ, King GF. Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na1.7. Biochemical Pharmacology. 114080. PMID 32511987 DOI: 10.1016/J.Bcp.2020.114080 |
0.337 |
|
| 2020 |
Muttenthaler M, Nevin ST, Inserra M, Lewis RJ, Adams DJ, Alewood P. On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. Australian Journal of Chemistry. 73: 327-333. PMID 32394983 DOI: 10.1071/Ch19456 |
0.447 |
|
| 2020 |
Mohan MK, Abraham N, R P R, Jayaseelan BF, Ragnarsson L, Lewis RJ, Sarma SP. Structure and allosteric activity of a single disulfide conopeptide from at human α3β4 and α7 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. PMID 32234761 DOI: 10.1074/Jbc.Ra119.012098 |
0.361 |
|
| 2020 |
Giribaldi J, Ragnarsson L, Pujante T, Enjalbal C, Wilson D, Daly NL, Lewis RJ, Dutertre S. Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from . Marine Drugs. 18. PMID 32155768 DOI: 10.3390/Md18030150 |
0.342 |
|
| 2019 |
Dutt M, Giacomotto J, Ragnarsson L, Andersson Å, Brust A, Dekan Z, Alewood PF, Lewis RJ. The α-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa. Scientific Reports. 9: 17841. PMID 31780714 DOI: 10.1038/S41598-019-54186-Y |
0.335 |
|
| 2019 |
Dongol Y, Caldas Cardoso F, Lewis RJ. Spider Knottin Pharmacology at Voltage-Gated Sodium Channels and Their Potential to Modulate Pain Pathways. Toxins. 11. PMID 31671792 DOI: 10.3390/Toxins11110626 |
0.325 |
|
| 2019 |
Jin AH, Muttenthaler M, Dutertre S, Himaya SWA, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. Conotoxins: Chemistry and Biology. Chemical Reviews. PMID 31633928 DOI: 10.1021/Acs.Chemrev.9B00207 |
0.357 |
|
| 2019 |
Cardoso FC, Lewis RJ. Structure-Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels. Frontiers in Pharmacology. 10: 366. PMID 31031623 DOI: 10.3389/Fphar.2019.00366 |
0.368 |
|
| 2019 |
Jin AH, Cristofori-Armstrong B, Rash LD, Román González SA, Espinosa RA, Lewis RJ, Alewood PF, Vetter I. Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochemical Pharmacology. PMID 31028742 DOI: 10.1016/J.Bcp.2019.04.025 |
0.363 |
|
| 2019 |
Ziegman R, Brust A, Jha P, Cardoso FC, Lewis RJ, Alewood PF. 'Messy' Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency. Marine Drugs. 17. PMID 30875751 DOI: 10.3390/Md17030165 |
0.351 |
|
| 2019 |
Ferraz CR, Arrahman A, Xie C, Casewell NR, Lewis RJ, Kool J, Cardoso FC. Multifunctional Toxins in Snake Venoms and Therapeutic Implications: From Pain to Hemorrhage and Necrosis Frontiers in Ecology and Evolution. 7. DOI: 10.3389/Fevo.2019.00218 |
0.326 |
|
| 2018 |
Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ. Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports. 8: 13397. PMID 30194442 DOI: 10.1038/S41598-018-31245-4 |
0.461 |
|
| 2018 |
Abraham N, Lewis RJ. Neuronal Nicotinic Acetylcholine Receptor Modulators from Cone Snails. Marine Drugs. 16. PMID 29899286 DOI: 10.3390/Md16060208 |
0.333 |
|
| 2018 |
Slagboom J, Otvos RA, Cardoso FC, Iyer J, Visser JC, van Doodewaerd BR, McCleary RJR, Niessen WMA, Somsen GW, Lewis RJ, Kini RM, Smit AB, Casewell NR, Kool J. Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling. Toxicon : Official Journal of the International Society On Toxinology. PMID 29730150 DOI: 10.1016/J.Toxicon.2018.04.022 |
0.339 |
|
| 2018 |
Sairaman A, Cardoso FC, Bispat A, Lewis RJ, Duggan PJ, Tuck KL. Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels. Bioorganic & Medicinal Chemistry. PMID 29622412 DOI: 10.1016/J.Bmc.2018.03.031 |
0.302 |
|
| 2018 |
Himaya SWA, Lewis RJ. Venomics-Accelerated Cone Snail Venom Peptide Discovery. International Journal of Molecular Sciences. 19. PMID 29522462 DOI: 10.3390/Ijms19030788 |
0.314 |
|
| 2018 |
Himaya SWA, Marí F, Lewis RJ. Accelerated proteomic visualization of individual predatory venoms of Conus purpurascens reveals separately evolved predation-evoked venom cabals. Scientific Reports. 8: 330. PMID 29321522 DOI: 10.1038/S41598-017-17422-X |
0.302 |
|
| 2018 |
Stefanucci A, Novellino E, Macedonio G, Dimmito MP, Mirzaie S, Cardoso FC, Lewis R, Zádor F, Erdei AI, Dvorácskó S, Tömböly C, Benyhe S, Pieretti S, Minosi P, Mollica A. Design, synthesis and biological profile of mixed opioid agonist/N-VGCC blocker peptides New Journal of Chemistry. 42: 5656-5659. DOI: 10.1039/C7Nj04969B |
0.304 |
|
| 2017 |
Adams DJ, Lewis RJ. Neuropharmacology of venom peptides. Neuropharmacology. PMID 29154773 DOI: 10.1016/J.Neuropharm.2017.11.025 |
0.408 |
|
| 2017 |
Prashanth JR, Dutertre S, Lewis RJ. Pharmacology of predatory and defensive venom peptides in cone snails. Molecular Biosystems. PMID 29090697 DOI: 10.1039/C7Mb00511C |
0.316 |
|
| 2017 |
Jin AH, Dekan Z, Smout MJ, Wilson D, Dutertre S, Vetter I, Lewis RJ, Loukas A, Daly NL, Alewood PF. Conotoxin Φ-MiXXVIIA from the new superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity. Angewandte Chemie (International Ed. in English). PMID 28984021 DOI: 10.1002/Anie.201708927 |
0.366 |
|
| 2017 |
Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ. Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. Plos One. 12: e0182848. PMID 28880874 DOI: 10.1371/Journal.Pone.0182848 |
0.352 |
|
| 2017 |
Touska F, Sattler S, Malsch P, Lewis RJ, Reeh PW, Zimmermann K. Ciguatoxins Evoke Potent CGRP Release by Activation of Voltage-Gated Sodium Channel Subtypes NaV1.9, NaV1.7 and NaV1.1. Marine Drugs. 15. PMID 28867800 DOI: 10.3390/Md15090269 |
0.331 |
|
| 2017 |
Cardoso FC, Lewis RJ. Sodium channels and pain: from toxins to therapies. British Journal of Pharmacology. PMID 28749537 DOI: 10.1111/Bph.13962 |
0.314 |
|
| 2017 |
McArthur JR, Motin L, Gleeson EC, Spiller S, Lewis RJ, Duggan PJ, Tuck KL, Adams DJ. Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. British Journal of Pharmacology. PMID 28608537 DOI: 10.1111/Bph.13910 |
0.422 |
|
| 2017 |
Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ. Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology. PMID 28542706 DOI: 10.1111/Bph.13865 |
0.305 |
|
| 2017 |
Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, et al. The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity. Scientific Reports. 7: 974. PMID 28428547 DOI: 10.1038/S41598-017-01129-0 |
0.453 |
|
| 2017 |
Windley MJ, Vetter I, Lewis RJ, Nicholson GM. Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors. Neuropharmacology. PMID 28396143 DOI: 10.1016/J.Neuropharm.2017.04.008 |
0.36 |
|
| 2017 |
Abraham N, Healy M, Ragnarsson L, Brust A, Alewood PF, Lewis RJ. Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Scientific Reports. 7: 45466. PMID 28361878 DOI: 10.1038/Srep45466 |
0.312 |
|
| 2017 |
Rahnama S, Deuis JR, Cardoso FC, Ramanujam V, Lewis RJ, Rash LD, King GF, Vetter I, Mobli M. The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant. Plos One. 12: e0173551. PMID 28301520 DOI: 10.1371/Journal.Pone.0173551 |
0.355 |
|
| 2017 |
Inserra MC, Israel MR, Caldwell A, Castro J, Deuis JR, Harrington AM, Keramidas A, Garcia-Caraballo S, Maddern J, Erickson A, Grundy L, Rychkov GY, Zimmermann K, Lewis RJ, Brierley SM, et al. Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports. 7: 42810. PMID 28225079 DOI: 10.1038/Srep42810 |
0.332 |
|
| 2017 |
Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, ... ... Lewis RJ, et al. Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a. Scientific Reports. 7: 40883. PMID 28106092 DOI: 10.1038/Srep40883 |
0.333 |
|
| 2017 |
Wan J, Mobli M, Brust A, Muttenthaler M, Andersson Å, Ragnarsson L, Castro J, Vetter I, Huang JX, Nilsson M, Brierley SM, Cooper MA, Lewis RJ, Alewood PF. Synthesis of Multivalent [Lys8]-Oxytocin Dendrimers that Inhibit Visceral Nociceptive Responses Australian Journal of Chemistry. 70: 162. DOI: 10.1071/Ch16407 |
0.348 |
|
| 2016 |
Over B, Matsson P, Tyrchan C, Artursson P, Doak BC, Foley MA, Hilgendorf C, Johnston SE, Lee MD, Lewis RJ, McCarren P, Muncipinto G, Norinder U, Perry MW, Duvall JR, et al. Structural and conformational determinants of macrocycle cell permeability. Nature Chemical Biology. PMID 27748751 DOI: 10.1038/Nchembio.2203 |
0.31 |
|
| 2016 |
Bressan E, Touska F, Vetter I, Kistner K, Kichko TI, Teixeira NB, Picolo G, Cury Y, Lewis RJ, Fischer MJ, Zimmermann K, Reeh PW. Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia. Pain. PMID 27434506 DOI: 10.1097/J.Pain.0000000000000669 |
0.348 |
|
| 2016 |
Deuis JR, Dekan Z, Inserra MC, Lee TH, Aguilar MI, Craik DJ, Lewis RJ, Alewood PF, Mobli M, Schroeder CI, Henriques ST, Vetter I. Development of a μO-conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Target NaV1.8. The Journal of Biological Chemistry. PMID 27026701 DOI: 10.1074/Jbc.M116.721662 |
0.324 |
|
| 2016 |
Wan J, Brust A, Bhola RF, Jha P, Mobli M, Lewis RJ, Christie MJ, Alewood PF. Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 26910400 DOI: 10.1002/Psc.2857 |
0.325 |
|
| 2015 |
Prashanth JR, Dutertre S, Jin AH, Lavergne V, Hamilton B, Cardoso FC, Griffin J, Venter DJ, Alewood PF, Lewis RJ. The role of defensive ecological interactions in the evolution of conotoxins. Molecular Ecology. PMID 26614983 DOI: 10.1111/Mec.13504 |
0.315 |
|
| 2015 |
Jin AH, Vetter I, Himaya SW, Alewood PF, Lewis RJ, Dutertre S. Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom. Proteomics. PMID 26506909 DOI: 10.1002/Pmic.201500220 |
0.313 |
|
| 2015 |
Himaya SW, Jin AH, Dutertre S, Giacomotto J, Mohialdeen H, Vetter I, Alewood PF, Lewis RJ. Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus. Journal of Proteome Research. 14: 4372-81. PMID 26322961 DOI: 10.1021/Acs.Jproteome.5B00630 |
0.358 |
|
| 2015 |
Deuis JR, Whately E, Brust A, Inserra MC, Asvadi NH, Lewis RJ, Alewood PF, Cabot PJ, Vetter I. Activation of κ Opioid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia. Acs Chemical Neuroscience. 6: 1751-8. PMID 26225903 DOI: 10.1021/Acschemneuro.5B00113 |
0.301 |
|
| 2015 |
Jin AH, Israel MR, Inserra MC, Smith JJ, Lewis RJ, Alewood PF, Vetter I, Dutertre S. δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proceedings. Biological Sciences / the Royal Society. 282. PMID 26156767 DOI: 10.1098/Rspb.2015.0817 |
0.348 |
|
| 2015 |
Cardoso FC, Dekan Z, Rosengren KJ, Erickson A, Vetter I, Deuis JR, Herzig V, Alewood PF, King GF, Lewis RJ. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens. Molecular Pharmacology. 88: 291-303. PMID 25979003 DOI: 10.1124/Mol.115.098178 |
0.38 |
|
| 2015 |
Gleeson EC, Graham JE, Spiller S, Vetter I, Lewis RJ, Duggan PJ, Tuck KL. Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives. Marine Drugs. 13: 2030-45. PMID 25871286 DOI: 10.3390/Md13042030 |
0.31 |
|
| 2015 |
Klint JK, Smith JJ, Vetter I, Rupasinghe DB, Er SY, Senff S, Herzig V, Mobli M, Lewis RJ, Bosmans F, King GF. Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach. British Journal of Pharmacology. 172: 2445-58. PMID 25754331 DOI: 10.1111/Bph.13081 |
0.307 |
|
| 2015 |
Wan J, Huang JX, Vetter I, Mobli M, Lawson J, Tae HS, Abraham N, Paul B, Cooper MA, Adams DJ, Lewis RJ, Alewood PF. α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. Journal of the American Chemical Society. 137: 3209-12. PMID 25710197 DOI: 10.1021/Jacs.5B00244 |
0.427 |
|
| 2015 |
Mueller A, Starobova H, Inserra MC, Jin AH, Deuis JR, Dutertre S, Lewis RJ, Alewood PF, Daly NL, Vetter I. α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochemical Pharmacology. 94: 155-63. PMID 25646788 DOI: 10.1016/J.Bcp.2015.01.011 |
0.312 |
|
| 2015 |
Ragnarsson L, Andersson Å, Thomas WG, Lewis RJ. Extracellular surface residues of the α1B-adrenoceptor critical for G protein-coupled receptor function. Molecular Pharmacology. 87: 121-9. PMID 25352041 DOI: 10.1124/Mol.114.094557 |
0.306 |
|
| 2014 |
Hopping G, Wang CI, Hogg RC, Nevin ST, Lewis RJ, Adams DJ, Alewood PF. Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors. Biochemical Pharmacology. 91: 534-42. PMID 25101833 DOI: 10.1016/J.Bcp.2014.07.025 |
0.447 |
|
| 2014 |
Hoyland CN, Aldridge C, Cleverley RM, Duchêne MC, Minasov G, Onopriyenko O, Sidiq K, Stogios PJ, Anderson WF, Daniel RA, Savchenko A, Vollmer W, Lewis RJ. Structure of the LdcB LD-carboxypeptidase reveals the molecular basis of peptidoglycan recognition. Structure (London, England : 1993). 22: 949-60. PMID 24909784 DOI: 10.1016/J.Str.2014.04.015 |
0.32 |
|
| 2014 |
Wang CI, Reeks T, Vetter I, Vergara I, Kovtun O, Lewis RJ, Alewood PF, Durek T. Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom. Biochemistry. 53: 3758-66. PMID 24867092 DOI: 10.1021/Bi5004475 |
0.344 |
|
| 2014 |
Heus F, Otvos RA, Aspers RL, van Elk R, Halff JI, Ehlers AW, Dutertre S, Lewis RJ, Wijmenga S, Smit AB, Niessen WM, Kool J. Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail. Biology. 3: 139-56. PMID 24833338 DOI: 10.3390/Biology3010139 |
0.313 |
|
| 2014 |
Akondi KB, Muttenthaler M, Dutertre S, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. Discovery, synthesis, and structure-activity relationships of conotoxins. Chemical Reviews. 114: 5815-47. PMID 24720541 DOI: 10.1021/Cr400401E |
0.306 |
|
| 2014 |
de Araujo AD, Mobli M, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan J, Lewis RJ, King GF, Brierley SM, Alewood PF. Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications. 5: 3165. PMID 24476666 DOI: 10.1038/Ncomms4165 |
0.334 |
|
| 2014 |
Jin AH, Vetter I, Dutertre S, Abraham N, Emidio NB, Inserra M, Murali SS, Christie MJ, Alewood PF, Lewis RJ. MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors. Biochemistry. 53: 1-3. PMID 24351107 DOI: 10.1021/Bi400882S |
0.318 |
|
| 2014 |
Akondi KB, Lewis RJ, Alewood PF. Re-engineering the μ-conotoxin SIIIA scaffold. Biopolymers. 101: 347-54. PMID 23913763 DOI: 10.1002/Bip.22368 |
0.341 |
|
| 2013 |
Sadeghi M, Murali SS, Lewis RJ, Alewood PF, Mohammadi S, Christie MJ. Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration. Molecular Pain. 9: 51. PMID 24139484 DOI: 10.1186/1744-8069-9-51 |
0.305 |
|
| 2013 |
Vetter I, Hein A, Sattler S, Hessler S, Touska F, Bressan E, Parra A, Hager U, Leffler A, Boukalova S, Nissen M, Lewis RJ, Belmonte C, Alzheimer C, Huth T, et al. Amplified cold transduction in native nociceptors by M-channel inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16627-41. PMID 24133266 DOI: 10.1523/Jneurosci.1473-13.2013 |
0.317 |
|
| 2013 |
Brust A, Wang CI, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF. Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter. Angewandte Chemie (International Ed. in English). 52: 12020-3. PMID 24115503 DOI: 10.1002/Anie.201304660 |
0.3 |
|
| 2013 |
Jin AH, Dutertre S, Kaas Q, Lavergne V, Kubala P, Lewis RJ, Alewood PF. Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Molecular & Cellular Proteomics : McP. 12: 3824-33. PMID 24043424 DOI: 10.1074/Mcp.M113.030353 |
0.329 |
|
| 2013 |
Inserra MC, Kompella SN, Vetter I, Brust A, Daly NL, Cuny H, Craik DJ, Alewood PF, Adams DJ, Lewis RJ. Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochemical Pharmacology. 86: 791-9. PMID 23924607 DOI: 10.1016/J.Bcp.2013.07.016 |
0.463 |
|
| 2013 |
Zimmermann K, Deuis JR, Inserra MC, Collins LS, Namer B, Cabot PJ, Reeh PW, Lewis RJ, Vetter I. Analgesic treatment of ciguatoxin-induced cold allodynia. Pain. 154: 1999-2006. PMID 23778293 DOI: 10.1016/J.Pain.2013.06.015 |
0.322 |
|
| 2013 |
Jayamanne A, Jeong HJ, Schroeder CI, Lewis RJ, Christie MJ, Vaughan CW. Spinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model. British Journal of Pharmacology. 170: 245-54. PMID 23713957 DOI: 10.1111/Bph.12251 |
0.306 |
|
| 2013 |
Deuis JR, Zimmermann K, Romanovsky AA, Possani LD, Cabot PJ, Lewis RJ, Vetter I. An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways. Pain. 154: 1749-57. PMID 23711479 DOI: 10.1016/J.Pain.2013.05.032 |
0.314 |
|
| 2013 |
Smith JJ, Vetter I, Lewis RJ, Peigneur S, Tytgat J, Lam A, Gallant EM, Beard NA, Alewood PF, Dulhunty AF. Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins. Proceedings of the National Academy of Sciences of the United States of America. 110: 8906-11. PMID 23671114 DOI: 10.1073/Pnas.1214062110 |
0.357 |
|
| 2013 |
Sousa SR, Vetter I, Ragnarsson L, Lewis RJ. Expression and pharmacology of endogenous Cav channels in SH-SY5Y human neuroblastoma cells. Plos One. 8: e59293. PMID 23536870 DOI: 10.1371/Journal.Pone.0059293 |
0.344 |
|
| 2013 |
Durek T, Vetter I, Wang CI, Motin L, Knapp O, Adams DJ, Lewis RJ, Alewood PF. Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1. Acs Chemical Biology. 8: 1215-22. PMID 23527544 DOI: 10.1021/Cb400012K |
0.478 |
|
| 2013 |
Sousa SR, Vetter I, Lewis RJ. Venom peptides as a rich source of cav2.2 channel blockers. Toxins. 5: 286-314. PMID 23381143 DOI: 10.3390/Toxins5020286 |
0.3 |
|
| 2013 |
Brust A, Sunagar K, Undheim EA, Vetter I, Yang DC, Yang DC, Casewell NR, Jackson TN, Koludarov I, Alewood PF, Hodgson WC, Lewis RJ, King GF, Antunes A, Hendrikx I, et al. Differential evolution and neofunctionalization of snake venom metalloprotease domains. Molecular & Cellular Proteomics : McP. 12: 651-63. PMID 23242553 DOI: 10.1074/Mcp.M112.023135 |
0.328 |
|
| 2013 |
Ragnarsson L, Wang CI, Andersson Ã…, Fajarningsih D, Monks T, Brust A, Rosengren KJ, Lewis RJ. Conopeptide Ï-TIA defines a new allosteric site on the extracellular surface of the α1B-adrenoceptor. The Journal of Biological Chemistry. 288: 1814-27. PMID 23184947 DOI: 10.1074/Jbc.M112.430785 |
0.337 |
|
| 2013 |
Dutertre S, Jin AH, Kaas Q, Jones A, Alewood PF, Lewis RJ. Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Molecular & Cellular Proteomics : McP. 12: 312-29. PMID 23152539 DOI: 10.1074/Mcp.M112.021469 |
0.316 |
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| 2013 |
Wang CI, Lewis RJ. Emerging opportunities for allosteric modulation of G-protein coupled receptors. Biochemical Pharmacology. 85: 153-62. PMID 22975406 DOI: 10.1016/J.Bcp.2012.09.001 |
0.31 |
|
| 2012 |
Schroeder CI, Nielsen KJ, Adams DA, Loughnan M, Thomas L, Alewood PF, Lewis RJ, Craik DJ. Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers. 98: 345-56. PMID 23193599 DOI: 10.1002/Bip.22031 |
0.342 |
|
| 2012 |
Vetter I, Touska F, Hess A, Hinsbey R, Sattler S, Lampert A, Sergejeva M, Sharov A, Collins LS, Eberhardt M, Engel M, Cabot PJ, Wood JN, Vlachová V, Reeh PW, ... Lewis RJ, et al. Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. The Embo Journal. 31: 3795-808. PMID 22850668 DOI: 10.1038/Emboj.2012.207 |
0.315 |
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| 2012 |
Vetter I, Lewis RJ. Therapeutic potential of cone snail venom peptides (conopeptides). Current Topics in Medicinal Chemistry. 12: 1546-52. PMID 22827523 DOI: 10.2174/156802612802652457 |
0.334 |
|
| 2012 |
Marcon F, Leblanc M, Vetter I, Lewis RJ, Escoubas P, Nicholson GM. Pharmacological characterization of α-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): an atypical long-chain α-neurotoxin with only weak affinity for α7 nicotinic receptors. Biochemical Pharmacology. 84: 851-63. PMID 22771828 DOI: 10.1016/J.Bcp.2012.06.024 |
0.326 |
|
| 2012 |
Schroeder CI, Adams D, Thomas L, Alewood PF, Lewis RJ. N- and C-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers. 98: 161-5. PMID 22733528 DOI: 10.1002/Bip.22032 |
0.362 |
|
| 2012 |
Vetter I, Dekan Z, Knapp O, Adams DJ, Alewood PF, Lewis RJ. Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochemical Pharmacology. 84: 540-8. PMID 22609441 DOI: 10.1016/J.Bcp.2012.05.008 |
0.445 |
|
| 2012 |
Dekan Z, Wang CI, Andrews RK, Lewis RJ, Alewood PF. Conotoxin engineering: dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability. Organic & Biomolecular Chemistry. 10: 5791-4. PMID 22581211 DOI: 10.1039/C2Ob25133G |
0.306 |
|
| 2012 |
Prashanth JR, Lewis RJ, Dutertre S. Towards an integrated venomics approach for accelerated conopeptide discovery. Toxicon : Official Journal of the International Society On Toxinology. 60: 470-7. PMID 22564717 DOI: 10.1016/J.Toxicon.2012.04.340 |
0.314 |
|
| 2012 |
Knapp O, Nevin ST, Yasuda T, Lawrence N, Lewis RJ, Adams DJ. Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB. British Journal of Pharmacology. 166: 2148-60. PMID 22452751 DOI: 10.1111/J.1476-5381.2012.01955.X |
0.424 |
|
| 2012 |
Lewis RJ, Dutertre S, Vetter I, Christie MJ. Conus venom peptide pharmacology. Pharmacological Reviews. 64: 259-98. PMID 22407615 DOI: 10.1124/Pr.111.005322 |
0.367 |
|
| 2012 |
Lewis RJ. Discovery and development of the χ-conopeptide class of analgesic peptides. Toxicon : Official Journal of the International Society On Toxinology. 59: 524-8. PMID 21839105 DOI: 10.1016/J.Toxicon.2011.07.012 |
0.321 |
|
| 2011 |
Dekan Z, Vetter I, Daly NL, Craik DJ, Lewis RJ, Alewood PF. α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure. Journal of the American Chemical Society. 133: 15866-9. PMID 21899353 DOI: 10.1021/Ja206408Q |
0.331 |
|
| 2011 |
Inserra MC, Lewis RJ. Venom Peptide modulators of the immune system. Inflammation & Allergy Drug Targets. 10: 399-410. PMID 21824080 DOI: 10.2174/187152811797200687 |
0.352 |
|
| 2011 |
Debieux CM, Dridge EJ, Mueller CM, Splatt P, Paszkiewicz K, Knight I, Florance H, Love J, Titball RW, Lewis RJ, Richardson DJ, Butler CS. A bacterial process for selenium nanosphere assembly. Proceedings of the National Academy of Sciences of the United States of America. 108: 13480-5. PMID 21808043 DOI: 10.1073/Pnas.1105959108 |
0.301 |
|
| 2011 |
Montanier CY, Correia MA, Flint JE, Zhu Y, Baslé A, McKee LS, Prates JA, Polizzi SJ, Coutinho PM, Lewis RJ, Henrissat B, Fontes CM, Gilbert HJ. A novel, noncatalytic carbohydrate-binding module displays specificity for galactose-containing polysaccharides through calcium-mediated oligomerization. The Journal of Biological Chemistry. 286: 22499-509. PMID 21454512 DOI: 10.1074/Jbc.M110.217372 |
0.302 |
|
| 2010 |
Morales RA, Daly NL, Vetter I, Mobli M, Napier IA, Craik DJ, Lewis RJ, Christie MJ, King GF, Alewood PF, Durek T. Chemical synthesis and structure of the prokineticin Bv8. Chembiochem : a European Journal of Chemical Biology. 11: 1882-8. PMID 20677202 DOI: 10.1002/Cbic.201000330 |
0.355 |
|
| 2010 |
Grishin AA, Wang CI, Muttenthaler M, Alewood PF, Lewis RJ, Adams DJ. Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 285: 22254-63. PMID 20466726 DOI: 10.1074/Jbc.M110.111880 |
0.442 |
|
| 2010 |
Dutertre S, Lewis RJ. Use of venom peptides to probe ion channel structure and function Journal of Biological Chemistry. 285: 13315-13320. PMID 20189991 DOI: 10.1074/Jbc.R109.076596 |
0.347 |
|
| 2010 |
Muttenthaler M, Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu SH, Armishaw CJ, Wang CI, Lewis RJ, Martin JL, Noakes PG, Craik DJ, Adams DJ, Alewood PF. Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists. Journal of the American Chemical Society. 132: 3514-22. PMID 20163143 DOI: 10.1021/Ja910602H |
0.426 |
|
| 2010 |
Luo S, Akondi KB, Zhangsun D, Wu Y, Zhu X, Hu Y, Christensen S, Dowell C, Daly NL, Craik DJ, Wang CIA, Lewis RJ, Alewood PF, McIntosh JM. Atypical α-conotoxin LtIA from Conus litteratus targets a novel microsite of the α3β2 nicotinic receptor Journal of Biological Chemistry. 285: 12355-12366. PMID 20145249 DOI: 10.1074/Jbc.M109.079012 |
0.322 |
|
| 2010 |
Berecki G, Motin L, Haythornthwaite A, Vink S, Bansal P, Drinkwater R, Wang CI, Moretta M, Lewis RJ, Alewood PF, Christie MJ, Adams DJ. Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Molecular Pharmacology. 77: 139-48. PMID 19892914 DOI: 10.1124/Mol.109.058834 |
0.475 |
|
| 2010 |
Vetter I, Lewis RJ. Characterization of endogenous calcium responses in neuronal cell lines Biochemical Pharmacology. 79: 908-920. PMID 19883631 DOI: 10.1016/J.Bcp.2009.10.020 |
0.304 |
|
| 2009 |
Lewis RJ. Conotoxin venom peptide therapeutics Advances in Experimental Medicine and Biology. 655: 44-48. PMID 20047034 DOI: 10.1007/978-1-4419-1132-2_5 |
0.321 |
|
| 2009 |
Brust A, Palant E, Croker DE, Colless B, Drinkwater R, Patterson B, Schroeder CI, Wilson D, Nielsen CK, Smith MT, Alewood D, Alewood PF, Lewis RJ. chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry. 52: 6991-7002. PMID 19860431 DOI: 10.1021/Jm9003413 |
0.319 |
|
| 2009 |
Chan LY, Wang CK, Major JM, Greenwood KP, Lewis RJ, Craik DJ, Daly NL. Isolation and characterization of peptides from Momordica cochinchinensis seeds. Journal of Natural Products. 72: 1453-8. PMID 19711988 DOI: 10.1021/Np900174N |
0.311 |
|
| 2009 |
Loughnan ML, Nicke A, Lawrence N, Lewis RJ. Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry. 48: 3717-29. PMID 19275168 DOI: 10.1021/Bi9000326 |
0.314 |
|
| 2009 |
Lewis RJ. Conotoxins: molecular and therapeutic targets Progress in Molecular and Subcellular Biology. 46: 45-65. PMID 19184584 DOI: 10.1007/978-3-540-87895-7_2 |
0.324 |
|
| 2009 |
Zamponi GW, Lewis RJ, Todorovic SM, Arneric SP, Snutch TP. Role of voltage-gated calcium channels in ascending pain pathways. Brain Research Reviews. 60: 84-9. PMID 19162069 DOI: 10.1016/J.Brainresrev.2008.12.021 |
0.333 |
|
| 2009 |
Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL. Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. The Journal of Biological Chemistry. 284: 4944-51. PMID 19098004 DOI: 10.1074/Jbc.M804950200 |
0.458 |
|
| 2009 |
Hopping G, Lewis RJ, Alewood PF. Rapid access to ω-conotoxin chimeras using native chemical ligation Australian Journal of Chemistry. 62: 1333-1338. DOI: 10.1071/Ch09216 |
0.328 |
|
| 2008 |
Mattei C, Wen PJ, Nguyen-Huu TD, Alvarez M, Benoit E, Bourdelais AJ, Lewis RJ, Baden DG, Molgó J, Meunier FA. Brevenal inhibits pacific ciguatoxin-1B-induced neurosecretion from bovine chromaffin cells. Plos One. 3: e3448. PMID 18941627 DOI: 10.1371/Journal.Pone.0003448 |
0.323 |
|
| 2008 |
Jin AH, Daly NL, Nevin ST, Wang CI, Dutertre S, Lewis RJ, Adams DJ, Craik DJ, Alewood PF. Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function. Journal of Medicinal Chemistry. 51: 5575-84. PMID 18754612 DOI: 10.1021/Jm800278K |
0.42 |
|
| 2008 |
Schroeder CI, Ekberg J, Nielsen KJ, Adams D, Loughnan ML, Thomas L, Adams DJ, Alewood PF, Lewis RJ. Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. The Journal of Biological Chemistry. 283: 21621-8. PMID 18522941 DOI: 10.1074/Jbc.M802852200 |
0.47 |
|
| 2008 |
Duggan PJ, Faber JM, Graham JE, Lewis RJ, Lumsden NG, Tuck KL. Synthesis and Cav2.2 binding data for non-peptide mimetics of ω-conotoxin GVIA based on a 5-amino-anthranilamide core Australian Journal of Chemistry. 61: 11-15. DOI: 10.1071/Ch07327 |
0.337 |
|
| 2007 |
Dutertre S, Ulens C, Büttner R, Fish A, van Elk R, Kendel Y, Hopping G, Alewood PF, Schroeder C, Nicke A, Smit AB, Sixma TK, Lewis RJ. AChBP-targeted alpha-conotoxin correlates distinct binding orientations with nAChR subtype selectivity. The Embo Journal. 26: 3858-67. PMID 17660751 DOI: 10.1038/Sj.Emboj.7601785 |
0.332 |
|
| 2007 |
Blanchfield JT, Gallagher OP, Cros C, Lewis RJ, Alewood PF, Toth I. Oral absorption and in vivo biodistribution of alpha-conotoxin MII and a lipidic analogue. Biochemical and Biophysical Research Communications. 361: 97-102. PMID 17640618 DOI: 10.1016/J.Bbrc.2007.06.138 |
0.314 |
|
| 2007 |
Drew LJ, Rugiero F, Cesare P, Gale JE, Abrahamsen B, Bowden S, Heinzmann S, Robinson M, Brust A, Colless B, Lewis RJ, Wood JN. High-threshold mechanosensitive ion channels blocked by a novel conopeptide mediate pressure-evoked pain. Plos One. 2: e515. PMID 17565368 DOI: 10.1371/Journal.Pone.0000515 |
0.342 |
|
| 2007 |
Motin L, Yasuda T, Schroeder CI, Lewis RJ, Adams DJ. Omega-conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels. The European Journal of Neuroscience. 25: 435-44. PMID 17284184 DOI: 10.1111/J.1460-9568.2006.05299.X |
0.442 |
|
| 2007 |
Lewis RJ, Schroeder CI, Ekberg J, Nielsen KJ, Loughnan M, Thomas L, Adams DA, Drinkwater R, Adams DJ, Alewood PF. Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels. Molecular Pharmacology. 71: 676-85. PMID 17142296 DOI: 10.1124/Mol.106.028225 |
0.493 |
|
| 2007 |
Dekan Z, Paczkowski FA, Lewis RJ, Alewood PF. Synthesis and In vitro Biological Activity of Cyclic Lipophilic χ-Conotoxin MrIA Analogues International Journal of Peptide Research and Therapeutics. 13: 307-312. DOI: 10.1007/S10989-007-9083-2 |
0.34 |
|
| 2006 |
Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ. muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proceedings of the National Academy of Sciences of the United States of America. 103: 17030-5. PMID 17077153 DOI: 10.1073/Pnas.0601819103 |
0.426 |
|
| 2006 |
Schroeder CI, Doering CJ, Zamponi GW, Lewis RJ. N-type calcium channel blockers: novel therapeutics for the treatment of pain. Medicinal Chemistry (ShäRiqah (United Arab Emirates)). 2: 535-43. PMID 17017994 DOI: 10.2174/157340606778250216 |
0.302 |
|
| 2006 |
St Pierre L, Flight S, Masci PP, Hanchard KJ, Lewis RJ, Alewood PF, de Jersey J, Lavin MF. Cloning and characterisation of natriuretic peptides from the venom glands of Australian elapids. Biochimie. 88: 1923-31. PMID 16908092 DOI: 10.1016/J.Biochi.2006.06.014 |
0.322 |
|
| 2006 |
Dutertre S, Lumsden NG, Alewood PF, Lewis RJ. Isolation and characterisation of conomap-Vt, a D-amino acid containing excitatory peptide from the venom of a vermivorous cone snail. Febs Letters. 580: 3860-6. PMID 16797543 DOI: 10.1016/J.Febslet.2006.06.011 |
0.322 |
|
| 2006 |
Loughnan M, Nicke A, Jones A, Schroeder CI, Nevin ST, Adams DJ, Alewood PF, Lewis RJ. Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum. The Journal of Biological Chemistry. 281: 24745-55. PMID 16790424 DOI: 10.1074/Jbc.M603703200 |
0.493 |
|
| 2006 |
Dutertre S, Lewis RJ. Toxin insights into nicotinic acetylcholine receptors Biochemical Pharmacology. 72: 661-670. PMID 16716265 DOI: 10.1016/J.Bcp.2006.03.027 |
0.34 |
|
| 2006 |
Ragnarsson L, Yasuda T, Lewis RJ, Dodd PR, Adams DJ. NMDA receptor subunit-dependent modulation by conantokin-G and Ala7-conantokin-G. Journal of Neurochemistry. 96: 283-91. PMID 16336218 DOI: 10.1111/J.1471-4159.2005.03574.X |
0.397 |
|
| 2006 |
Schroeder CI, Lewis RJ. ω-Conotoxins GVIA, MVIIA and CVID: SAR and Clinical Potential. Marine Drugs. 4: 193-214. DOI: 10.3390/Md403193 |
0.311 |
|
| 2006 |
Nicholson GM, Lewis RJ. Ciguatoxins: Cyclic Polyether Modulators of Voltage-gated Iion Channel Function. Marine Drugs. 4: 82-118. DOI: 10.3390/Md403082 |
0.319 |
|
| 2006 |
Baell JB, Duggan PJ, Forsyth SA, Lewis RJ, Lok YP, Schroeder CI, Shepherd NE. Synthesis and biological evaluation of anthranilamide-based non-peptide mimetics of ω-conotoxin GVIA Tetrahedron. 62: 7284-7292. DOI: 10.1016/J.Tet.2006.05.041 |
0.314 |
|
| 2006 |
Brust A, Alewood D, Colless B, Palant E, Patterson B, Wilson DTR, Watson F, Schroeder CI, Alewood PF, Lewis RJ. conopeptide to drug: the development, structure and activity correlation of Xen2174 Journal of Peptide Science. 12: 516-516. DOI: 10.1002/Psc.797 |
0.347 |
|
| 2005 |
Nilsson KP, Lovelace ES, Caesar CE, Tynngård N, Alewood PF, Johansson HM, Sharpe IA, Lewis RJ, Daly NL, Craik DJ. Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter. Biopolymers. 80: 815-23. PMID 15931669 DOI: 10.1002/Bip.20302 |
0.328 |
|
| 2005 |
Lima V, Mueller A, Kamikihara SY, Raymundi V, Alewood D, Lewis RJ, Chen Z, Minneman KP, Pupo AS. Differential antagonism by conotoxin rho-TIA of contractions mediated by distinct alpha1-adrenoceptor subtypes in rat vas deferens, spleen and aorta. European Journal of Pharmacology. 508: 183-92. PMID 15680270 DOI: 10.1016/J.Ejphar.2004.12.011 |
0.309 |
|
| 2004 |
Baell JB, Duggan PJ, Forsyth SA, Lewis RJ, Lok YP, Schroeder CI. Synthesis and biological evaluation of nonpeptide mimetics of omega-conotoxin GVIA. Bioorganic & Medicinal Chemistry. 12: 4025-37. PMID 15246080 DOI: 10.1016/J.Bmc.2004.05.040 |
0.318 |
|
| 2004 |
Yasuda T, Chen L, Barr W, McRory JE, Lewis RJ, Adams DJ, Zamponi GW. Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells. The European Journal of Neuroscience. 20: 1-13. PMID 15245474 DOI: 10.1111/J.1460-9568.2004.03434.X |
0.44 |
|
| 2004 |
Schroeder CI, Smythe ML, Lewis RJ. Development of small molecules that mimic the binding of ω-conotoxins at the N-type voltage-gated calcium channel Molecular Diversity. 8: 127-134. PMID 15209164 DOI: 10.1023/B:Modi.0000025656.79632.86 |
0.359 |
|
| 2004 |
Dutertre S, Lewis RJ. Computational approaches to understand alpha-conotoxin interactions at neuronal nicotinic receptors. Febs Journal. 271: 2327-2334. PMID 15182348 DOI: 10.1111/J.1432-1033.2004.04147.X |
0.311 |
|
| 2004 |
Mould J, Yasuda T, Schroeder CI, Beedle AM, Doering CJ, Zamponi GW, Adams DJ, Lewis RJ. The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. The Journal of Biological Chemistry. 279: 34705-14. PMID 15166237 DOI: 10.1074/Jbc.M310848200 |
0.453 |
|
| 2004 |
Kloda A, Clements JD, Lewis RJ, Adams DJ. Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors. Molecular Pharmacology. 65: 1386-96. PMID 15155832 DOI: 10.1124/Mol.65.6.1386 |
0.415 |
|
| 2004 |
Lewis RJ. Conotoxins as selective inhibitors of neuronal ion channels, receptors and transporters Iubmb Life. 56: 89-93. PMID 15085932 DOI: 10.1080/15216540410001668055 |
0.348 |
|
| 2004 |
Daly NL, Ekberg JA, Thomas L, Adams DJ, Lewis RJ, Craik DJ. Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. The Journal of Biological Chemistry. 279: 25774-82. PMID 15044438 DOI: 10.1074/Jbc.M313002200 |
0.479 |
|
| 2004 |
Yasuda T, Lewis RJ, Adams DJ. Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation. The Journal of General Physiology. 123: 401-16. PMID 15024042 DOI: 10.1085/Jgp.200308967 |
0.419 |
|
| 2004 |
Loughnan ML, Nicke A, Jones A, Adams DJ, Alewood PF, Lewis RJ. Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone. Journal of Medicinal Chemistry. 47: 1234-41. PMID 14971903 DOI: 10.1021/Jm031010O |
0.451 |
|
| 2004 |
Ragnarsson LK, Yasuda T, Adams DJ, Lewis RJ, Dodd PR. NMDA receptor variant responses to conantokins Journal of Neurochemistry. 88: 67-67. DOI: 10.1046/J.1474-1644.2003.2314P26_01.X |
0.408 |
|
| 2003 |
Pottier I, Hamilton B, Jones A, Lewis RJ, Vernoux JP. Identification of slow and fast-acting toxins in a highly ciguatoxic barracuda (Sphyraena barracuda) by HPLC/MS and radiolabelled ligand binding. Toxicon : Official Journal of the International Society On Toxinology. 42: 663-72. PMID 14602122 DOI: 10.1016/J.Toxicon.2003.09.004 |
0.304 |
|
| 2003 |
Lewis RJ, Garcia ML. Therapeutic potential of venom peptides Nature Reviews Drug Discovery. 2: 790-802. PMID 14526382 DOI: 10.1038/Nrd1197 |
0.301 |
|
| 2003 |
Sharpe IA, Palant E, Schroeder CI, Kaye DM, Adams DJ, Alewood PF, Lewis RJ. Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship. The Journal of Biological Chemistry. 278: 40317-23. PMID 12885787 DOI: 10.1074/Jbc.M213030200 |
0.46 |
|
| 2003 |
Sharpe IA, Thomas L, Loughnan M, Motin L, Palant E, Croker DE, Alewood D, Chen S, Graham RM, Alewood PF, Adams DJ, Lewis RJ. Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA. The Journal of Biological Chemistry. 278: 34451-7. PMID 12824165 DOI: 10.1074/Jbc.M305410200 |
0.449 |
|
| 2003 |
Blanchfield JT, Dutton JL, Hogg RC, Gallagher OP, Craik DJ, Jones A, Adams DJ, Lewis RJ, Alewood PF, Toth I. Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. Journal of Medicinal Chemistry. 46: 1266-72. PMID 12646037 DOI: 10.1021/Jm020426J |
0.474 |
|
| 2003 |
Adams DJ, Smith AB, Schroeder CI, Yasuda T, Lewis RJ. Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals. The Journal of Biological Chemistry. 278: 4057-62. PMID 12441339 DOI: 10.1074/Jbc.M209969200 |
0.443 |
|
| 2003 |
Nicke A, Loughnan ML, Millard EL, Alewood PF, Adams DJ, Daly NL, Craik DJ, Lewis RJ. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. The Journal of Biological Chemistry. 278: 3137-44. PMID 12419800 DOI: 10.1074/Jbc.M210280200 |
0.405 |
|
| 2002 |
Hogg RC, Lewis RJ, Adams DJ. Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons. The European Journal of Neuroscience. 16: 242-8. PMID 12169106 DOI: 10.1046/J.1460-9568.2002.02071.X |
0.4 |
|
| 2002 |
Nielsen KJ, Watson M, Adams DJ, Hammarström AK, Gage PW, Hill JM, Craik DJ, Thomas L, Adams D, Alewood PF, Lewis RJ. Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels. The Journal of Biological Chemistry. 277: 27247-55. PMID 12006587 DOI: 10.1074/Jbc.M201611200 |
0.47 |
|
| 2001 |
Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ. Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter. Nature Neuroscience. 4: 902-7. PMID 11528421 DOI: 10.1038/Nn0901-902 |
0.454 |
|
| 2001 |
Blanchfield J, Dutton J, Hogg R, Craik D, Adams D, Lewis R, Alewood P, Toth I. The synthesis and structure of an n-terminal dodecanoic acid conjugate of α-conotoxin MII Letters in Peptide Science. 8: 235-239. DOI: 10.1023/A:1016577832311 |
0.458 |
|
| 2000 |
Hewitt L, Kasche V, Lummer K, Lewis RJ, Murshudov GN, Verma CS, Dodson GG, Wilson KS. Structure of a slow processing precursor penicillin acylase from Escherichia coli reveals the linker peptide blocking the active-site cleft. Journal of Molecular Biology. 302: 887-98. PMID 10993730 DOI: 10.1006/Jmbi.2000.4105 |
0.326 |
|
| 2000 |
Lewis RJ, Nielsen KJ, Craik DJ, Loughnan ML, Adams DA, Sharpe IA, Luchian T, Adams DJ, Bond T, Thomas L, Jones A, Matheson JL, Drinkwater R, Andrews PR, Alewood PF. Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. The Journal of Biological Chemistry. 275: 35335-44. PMID 10938268 DOI: 10.1074/Jbc.M002252200 |
0.447 |
|
| 2000 |
Hill JM, Atkins AR, Loughnan ML, Jones A, Adams DA, Martin RC, Lewis RJ, Craik DJ, Alewood PF. Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 1. Isolation, characterization and chemical synthesis. European Journal of Biochemistry / Febs. 267: 4642-8. PMID 10903496 DOI: 10.1046/J.1432-1327.2000.01508.X |
0.341 |
|
| 2000 |
Nielsen KJ, Schroeder T, Lewis R. Structure-activity relationships of omega-conotoxins at N-type voltage-sensitive calcium channels. Journal of Molecular Recognition : Jmr. 13: 55-70. PMID 10822250 DOI: 10.1002/(Sici)1099-1352(200003/04)13:2<55::Aid-Jmr488>3.0.Co;2-O |
0.351 |
|
| 2000 |
Lewis RJ, Muchová K, Brannigan JA, Barák I, Leonard G, Wilkinson AJ. Domain swapping in the sporulation response regulator Spo0A. Journal of Molecular Biology. 297: 757-70. PMID 10731426 DOI: 10.1006/Jmbi.2000.3598 |
0.306 |
|
| 2000 |
Lewis RJ. Ion channel toxins and therapeutics: From cone snail venoms to ciguatera Therapeutic Drug Monitoring. 22: 61-64. PMID 10688261 DOI: 10.1097/00007691-200002000-00013 |
0.318 |
|
| 1999 |
Hogg RC, Miranda LP, Craik DJ, Lewis RJ, Alewood PF, Adams DJ. Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 274: 36559-64. PMID 10593955 DOI: 10.1074/Jbc.274.51.36559 |
0.44 |
|
| 1999 |
Nielsen KJ, Adams D, Thomas L, Bond T, Alewood PF, Craik DJ, Lewis RJ. Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels. Journal of Molecular Biology. 289: 1405-21. PMID 10373375 DOI: 10.1006/Jmbi.1999.2817 |
0.479 |
|
| 1999 |
Nielsen KJ, Adams DA, Alewood PF, Lewis RJ, Thomas L, Schroeder T, Craik DJ. Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus. Biochemistry. 38: 6741-51. PMID 10346894 DOI: 10.1021/Bi982980U |
0.331 |
|
| 1999 |
Adams DJ, Alewood PF, Craik DJ, Drinkwater RD, Lewis RJ. Conotoxins and their potential pharmaceutical applications Drug Development Research. 46: 219-234. DOI: 10.1002/(Sici)1098-2299(199903/04)46:3/4<219::Aid-Ddr7>3.0.Co;2-S |
0.462 |
|
| 1998 |
Hogg RC, Lewis RJ, Adams DJ. Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones. Neuroscience Letters. 252: 103-6. PMID 9756332 DOI: 10.1016/S0304-3940(98)00575-8 |
0.432 |
|
| 1998 |
Hu SH, Loughnan M, Miller R, Weeks CM, Blessing RH, Alewood PF, Lewis RJ, Martin JL. The 1.1 A resolution crystal structure of [Tyr15]EpI, a novel alpha-conotoxin from Conus episcopatus, solved by direct methods. Biochemistry. 37: 11425-33. PMID 9708977 DOI: 10.1021/Bi9806549 |
0.345 |
|
| 1998 |
Loughnan M, Bond T, Atkins A, Cuevas J, Adams DJ, Broxton NM, Livett BG, Down JG, Jones A, Alewood PF, Lewis RJ. alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 273: 15667-74. PMID 9624161 DOI: 10.1074/Jbc.273.25.15667 |
0.469 |
|
| 1997 |
Scanlon MJ, Naranjo D, Thomas L, Alewood PF, Lewis RJ, Craik DJ. Solution structure and proposed binding mechanism of a novel potassium channel toxin kappa-conotoxin PVIIA. Structure (London, England : 1993). 5: 1585-97. PMID 9438859 DOI: 10.1016/S0969-2126(97)00307-9 |
0.325 |
|
| 1997 |
Poli MA, Lewis RJ, Dickey RW, Musser SM, Buckner CA, Carpenter LG. Identification of Caribbean ciguatoxins as the cause of an outbreak of fish poisoning among U.S. soldiers in Haiti. Toxicon : Official Journal of the International Society On Toxinology. 35: 733-41. PMID 9203298 DOI: 10.1016/S0041-0101(96)00166-3 |
0.306 |
|
| 1997 |
Skjaerbaek N, Nielsen KJ, Lewis RJ, Alewood P, Craik DJ. Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy. The Journal of Biological Chemistry. 272: 2291-9. PMID 8999936 DOI: 10.1074/Jbc.272.4.2291 |
0.306 |
|
| 1996 |
Nielsen KJ, Thomas L, Lewis RJ, Alewood PF, Craik DJ. A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202. Journal of Molecular Biology. 263: 297-310. PMID 8913308 DOI: 10.1006/Jmbi.1996.0576 |
0.356 |
|
| 1992 |
Lewis RJ. Ciguatoxins are potent ichthyotoxins Toxicon. 30: 207-211. PMID 1557790 DOI: 10.1016/0041-0101(92)90474-J |
0.313 |
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