Richard J. Lewis, PhD - Publications

Affiliations: 
University of Queensland University of Queensland, Saint Lucia, Queensland, Australia 

192 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 McMahon KL, Tran HNT, Deuis JR, Lewis RJ, Vetter I, Schroeder CI. Discovery, Pharmacological Characterisation and NMR Structure of the Novel µ-Conotoxin SxIIIC, a Potent and Irreversible Na Channel Inhibitor. Biomedicines. 8. PMID 33023152 DOI: 10.3390/biomedicines8100391  0.56
2020 Herzig V, Sunagar K, Wilson DTR, Pineda SS, Israel MR, Dutertre S, McFarland BS, Undheim EAB, Hodgson WC, Alewood PF, Lewis RJ, Bosmans F, Vetter I, King GF, Fry BG. Australian funnel-web spiders evolved human-lethal δ-hexatoxins for defense against vertebrate predators. Proceedings of the National Academy of Sciences of the United States of America. PMID 32958636 DOI: 10.1073/pnas.2004516117  0.8
2020 Cardoso FC, Marliac MA, Geoffroy C, Schmit M, Bispat A, Lewis RJ, Tuck KL, Duggan PJ. The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorganic & Medicinal Chemistry. 28: 115655. PMID 32828422 DOI: 10.1016/j.bmc.2020.115655  0.36
2020 Dutt M, Giacomotto J, Ragnarsson L, Andersson A, Brust A, Deakan Z, Alewood PF, Lewis RJ. Re-evaluating the nirvana cabal deployed by piscivorous cone snails. Toxicon : Official Journal of the International Society On Toxinology. 177: S9-S10. PMID 32635128 DOI: 10.1016/j.toxicon.2019.10.044  0.52
2020 Wang D, Himaya SWA, Giacomotto J, Hasan MM, Cardoso FC, Ragnarsson L, Lewis RJ. Characterisation of d-Conotoxin TxVIA as a Mammalian T-Type Calcium Channel Modulator. Marine Drugs. 18. PMID 32629781 DOI: 10.3390/md18070343  0.48
2020 Mohan MK, Abraham N, R P R, Jayaseelan BF, Ragnarsson L, Lewis RJ, Sarma SP. Correction: Structure and allosteric activity of a single-disulfide conopeptide from at human α3β4 and α7 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 295: 8872. PMID 32591448 DOI: 10.1074/jbc.AAC120.014456  0.4
2020 Rupasinghe DB, Herzig V, Vetter I, Dekan Z, Gilchrist J, Bosmans F, Alewood PF, Lewis RJ, King GF. Mutational analysis of ProTx-I and the novel venom peptide Pe1b provide insight into residues responsible for selective inhibition of the analgesic drug target Na1.7. Biochemical Pharmacology. 114080. PMID 32511987 DOI: 10.1016/j.bcp.2020.114080  0.52
2020 Muttenthaler M, Nevin ST, Inserra M, Lewis RJ, Adams DJ, Alewood P. On-resin strategy to label α-conotoxins: Cy5-RgIA, a potent α9α10 nicotinic acetylcholine receptor imaging probe. Australian Journal of Chemistry. 73: 327-333. PMID 32394983 DOI: 10.1071/ch19456  0.88
2020 Mohan MK, Abraham N, R P R, Jayaseelan BF, Ragnarsson L, Lewis RJ, Sarma SP. Structure and allosteric activity of a single disulfide conopeptide from at human α3β4 and α7 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. PMID 32234761 DOI: 10.1074/jbc.RA119.012098  0.4
2020 Jha P, Ragnarsson L, Lewis RJ. Structure-Function of the High Affinity Substrate Binding Site (S1) of Human Norepinephrine Transporter. Frontiers in Pharmacology. 11: 217. PMID 32210813 DOI: 10.3389/fphar.2020.00217  0.4
2020 Giribaldi J, Ragnarsson L, Pujante T, Enjalbal C, Wilson D, Daly NL, Lewis RJ, Dutertre S. Synthesis, Pharmacological and Structural Characterization of Novel Conopressins from . Marine Drugs. 18. PMID 32155768 DOI: 10.3390/md18030150  0.8
2020 Scheib H, Nekaris KA, Rode-Margono J, Ragnarsson L, Baumann K, Dobson JS, Wirdateti W, Nouwens A, Nijman V, Martelli P, Ma R, Lewis RJ, Kwok HF, Fry BG. The Toxicological Intersection between Allergen and Toxin: A Structural Comparison of the Cat Dander Allergenic Protein Fel d1 and the Slow Loris Brachial Gland Secretion Protein. Toxins. 12. PMID 32012831 DOI: 10.3390/toxins12020086  0.4
2019 Dutt M, Giacomotto J, Ragnarsson L, Andersson Å, Brust A, Dekan Z, Alewood PF, Lewis RJ. The α-adrenoceptor inhibitor ρ-TIA facilitates net hunting in piscivorous Conus tulipa. Scientific Reports. 9: 17841. PMID 31780714 DOI: 10.1038/s41598-019-54186-y  0.52
2019 Jin AH, Muttenthaler M, Dutertre S, Himaya SWA, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. Conotoxins: Chemistry and Biology. Chemical Reviews. PMID 31633928 DOI: 10.1021/acs.chemrev.9b00207  0.8
2019 Cardoso FC, Lewis RJ. Structure-Function and Therapeutic Potential of Spider Venom-Derived Cysteine Knot Peptides Targeting Sodium Channels. Frontiers in Pharmacology. 10: 366. PMID 31031623 DOI: 10.3389/fphar.2019.00366  0.36
2019 Jin AH, Cristofori-Armstrong B, Rash LD, Román González SA, Espinosa RA, Lewis RJ, Alewood PF, Vetter I. Novel conorfamides from Conus austini venom modulate both nicotinic acetylcholine receptors and acid-sensing ion channels. Biochemical Pharmacology. PMID 31028742 DOI: 10.1016/j.bcp.2019.04.025  0.52
2019 Jin AH, Dutertre S, Dutt M, Lavergne V, Jones A, Lewis RJ, Alewood PF. Transcriptomic-Proteomic Correlation in the Predation-Evoked Venom of the Cone Snail, . Marine Drugs. 17. PMID 30893765 DOI: 10.3390/md17030177  0.8
2019 Ziegman R, Brust A, Jha P, Cardoso FC, Lewis RJ, Alewood PF. 'Messy' Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency. Marine Drugs. 17. PMID 30875751 DOI: 10.3390/md17030165  0.52
2019 Ragnarsson L, Andersson Å, Thomas WG, Lewis RJ. Mutations in the NPxxY motif stabilize pharmacologically distinct conformational states of the α- and β-adrenoceptors. Science Signaling. 12. PMID 30862702 DOI: 10.1126/scisignal.aas9485  0.4
2018 Wang D, Neupane P, Ragnarsson L, Capon RJ, Lewis RJ. Synthesis of Pseudellone Analogs and Characterization as Novel T-type Calcium Channel Blockers. Marine Drugs. 16. PMID 30487473 DOI: 10.3390/md16120475  0.4
2018 Starobova H, S W A H, Lewis RJ, Vetter I. Transcriptomics in pain research: insights from new and old technologies. Molecular Omics. PMID 30374497 DOI: 10.1039/c8mo00181b  0.52
2018 Wang D, Ragnarsson L, Lewis RJ. Insight into T-type calcium channel structure, function and modulation. Current Medicinal Chemistry. PMID 30277145 DOI: 10.2174/0929867325666181001112821  0.4
2018 Sousa SR, McArthur JR, Brust A, Bhola RF, Rosengren KJ, Ragnarsson L, Dutertre S, Alewood PF, Christie MJ, Adams DJ, Vetter I, Lewis RJ. Novel analgesic ω-conotoxins from the vermivorous cone snail Conus moncuri provide new insights into the evolution of conopeptides. Scientific Reports. 8: 13397. PMID 30194442 DOI: 10.1038/s41598-018-31245-4  0.88
2018 Slagboom J, Otvos RA, Cardoso FC, Iyer J, Visser JC, van Doodewaerd BR, McCleary RJR, Niessen WMA, Somsen GW, Lewis RJ, Kini RM, Smit AB, Casewell NR, Kool J. Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling. Toxicon : Official Journal of the International Society On Toxinology. PMID 29730150 DOI: 10.1016/j.toxicon.2018.04.022  0.36
2018 Brust A, Wang CA, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF. Corrigendum: Vicinal Disulfide Constrained Cyclic Peptidomimetics: a Turn Mimetic Scaffold Targeting the Norepinephrine Transporter. Angewandte Chemie (International Ed. in English). 57: 5203. PMID 29701320 DOI: 10.1002/anie.201803138  0.52
2018 Sairaman A, Cardoso FC, Bispat A, Lewis RJ, Duggan PJ, Tuck KL. Synthesis and evaluation of aminobenzothiazoles as blockers of N- and T-type calcium channels. Bioorganic & Medicinal Chemistry. PMID 29622412 DOI: 10.1016/j.bmc.2018.03.031  0.36
2018 Himaya SWA, Lewis RJ. Venomics-Accelerated Cone Snail Venom Peptide Discovery. International Journal of Molecular Sciences. 19. PMID 29522462 DOI: 10.3390/ijms19030788  0.48
2018 Cardoso FC, Hasan M, Zhao T, Lewis RJ. Toxins in pain. Current Opinion in Supportive and Palliative Care. PMID 29438128 DOI: 10.1097/SPC.0000000000000335  0.36
2018 Himaya SWA, Marí F, Lewis RJ. Accelerated proteomic visualization of individual predatory venoms of Conus purpurascens reveals separately evolved predation-evoked venom cabals. Scientific Reports. 8: 330. PMID 29321522 DOI: 10.1038/s41598-017-17422-x  0.48
2018 Larsson ME, Laczka OF, Harwood DT, Lewis RJ, Himaya SWA, Murray SA, Doblin MA. Toxicology of Gambierdiscus spp. (Dinophyceae) from Tropical and Temperate Australian Waters. Marine Drugs. 16. PMID 29301247 DOI: 10.3390/md16010007  0.48
2017 Morgan M, Deuis JR, Woodruff TM, Lewis RJ, Vetter I. Role of complement anaphylatoxin receptors in a mouse model of acute burn-induced pain. Molecular Immunology. 94: 68-74. PMID 29274925 DOI: 10.1016/j.molimm.2017.12.016  0.52
2017 Muttenthaler M, Andersson Å, Vetter I, Menon R, Busnelli M, Ragnarsson L, Bergmayr C, Arrowsmith S, Deuis JR, Chiu HS, Palpant NJ, O'Brien M, Smith TJ, Wray S, Neumann ID, ... ... Lewis RJ, et al. Subtle modifications to oxytocin produce ligands that retain potency and improved selectivity across species. Science Signaling. 10. PMID 29208680 DOI: 10.1126/scisignal.aan3398  0.52
2017 Adams DJ, Lewis RJ. Neuropharmacology of venom peptides. Neuropharmacology. PMID 29154773 DOI: 10.1016/j.neuropharm.2017.11.025  0.88
2017 Morgan M, Deuis JR, Frøsig-Jørgensen M, Lewis RJ, Cabot PJ, Gray PD, Vetter I. Burn Pain: A Systematic and Critical Review of Epidemiology, Pathophysiology, and Treatment. Pain Medicine (Malden, Mass.). PMID 29036469 DOI: 10.1093/pm/pnx228  0.52
2017 Jin AH, Dekan Z, Smout MJ, Wilson D, Dutertre S, Vetter I, Lewis RJ, Loukas A, Daly NL, Alewood PF. Conotoxin Φ-MiXXVIIA from the new superfamily G2 employs a novel cysteine framework that mimics granulin and displays anti-apoptotic activity. Angewandte Chemie (International Ed. in English). PMID 28984021 DOI: 10.1002/anie.201708927  0.8
2017 Sousa SR, Wingerd JS, Brust A, Bladen C, Ragnarsson L, Herzig V, Deuis JR, Dutertre S, Vetter I, Zamponi GW, King GF, Alewood PF, Lewis RJ. Discovery and mode of action of a novel analgesic β-toxin from the African spider Ceratogyrus darlingi. Plos One. 12: e0182848. PMID 28880874 DOI: 10.1371/journal.pone.0182848  0.8
2017 Cardoso FC, Lewis RJ. Sodium channels and pain: from toxins to therapies. British Journal of Pharmacology. PMID 28749537 DOI: 10.1111/bph.13962  0.36
2017 McArthur JR, Motin L, Gleeson EC, Spiller S, Lewis RJ, Duggan PJ, Tuck KL, Adams DJ. Inhibition of human N- and T-type calcium channels by an ortho-phenoxyanilide derivative, MONIRO-1. British Journal of Pharmacology. PMID 28608537 DOI: 10.1111/bph.13910  0.88
2017 Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, ... ... Lewis RJ, et al. Corrigendum: Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a. Scientific Reports. 7: 46816. PMID 28548111 DOI: 10.1038/srep46816  0.52
2017 Cardoso FC, Dekan Z, Smith JJ, Deuis JR, Vetter I, Herzig V, Alewood PF, King GF, Lewis RJ. Modulatory features of the novel spider toxin μ-TRTX-Df1a isolated from the venom of the spider Davus fasciatus. British Journal of Pharmacology. PMID 28542706 DOI: 10.1111/bph.13865  0.52
2017 Wingerd JS, Mozar CA, Ussing CA, Murali SS, Chin YK, Cristofori-Armstrong B, Durek T, Gilchrist J, Vaughan CW, Bosmans F, Adams DJ, Lewis RJ, Alewood PF, Mobli M, Christie MJ, et al. The tarantula toxin β/δ-TRTX-Pre1a highlights the importance of the S1-S2 voltage-sensor region for sodium channel subtype selectivity. Scientific Reports. 7: 974. PMID 28428547 DOI: 10.1038/s41598-017-01129-0  0.88
2017 Windley MJ, Vetter I, Lewis RJ, Nicholson GM. Lethal effects of an insecticidal spider venom peptide involve positive allosteric modulation of insect nicotinic acetylcholine receptors. Neuropharmacology. PMID 28396143 DOI: 10.1016/j.neuropharm.2017.04.008  0.52
2017 Abraham N, Healy M, Ragnarsson L, Brust A, Alewood PF, Lewis RJ. Structural mechanisms for α-conotoxin activity at the human α3β4 nicotinic acetylcholine receptor. Scientific Reports. 7: 45466. PMID 28361878 DOI: 10.1038/srep45466  0.52
2017 Rahnama S, Deuis JR, Cardoso FC, Ramanujam V, Lewis RJ, Rash LD, King GF, Vetter I, Mobli M. The structure, dynamics and selectivity profile of a NaV1.7 potency-optimised huwentoxin-IV variant. Plos One. 12: e0173551. PMID 28301520 DOI: 10.1371/journal.pone.0173551  0.52
2017 Inserra MC, Israel MR, Caldwell A, Castro J, Deuis JR, Harrington AM, Keramidas A, Garcia-Caraballo S, Maddern J, Erickson A, Grundy L, Rychkov GY, Zimmermann K, Lewis RJ, Brierley SM, et al. Multiple sodium channel isoforms mediate the pathological effects of Pacific ciguatoxin-1. Scientific Reports. 7: 42810. PMID 28225079 DOI: 10.1038/srep42810  0.52
2017 Deuis JR, Dekan Z, Wingerd JS, Smith JJ, Munasinghe NR, Bhola RF, Imlach WL, Herzig V, Armstrong DA, Rosengren KJ, Bosmans F, Waxman SG, Dib-Hajj SD, Escoubas P, Minett MS, ... ... Lewis RJ, et al. Pharmacological characterisation of the highly NaV1.7 selective spider venom peptide Pn3a. Scientific Reports. 7: 40883. PMID 28106092 DOI: 10.1038/srep40883  0.52
2016 Yin K, Deuis JR, Lewis RJ, Vetter I. Transcriptomic and behavioural characterisation of a mouse model of burn pain identify the cholecystokinin 2 receptor as an analgesic target. Molecular Pain. 12. PMID 27573516 DOI: 10.1177/1744806916665366  0.52
2016 Lewis RJ, Inserra M, Vetter I, Holland WC, Hardison DR, Tester PA, Litaker RW. Rapid Extraction and Identification of Maitotoxin and Ciguatoxin-Like Toxins from Caribbean and Pacific Gambierdiscus Using a New Functional Bioassay. Plos One. 11: e0160006. PMID 27467390 DOI: 10.1371/journal.pone.0160006  0.52
2016 Bressan E, Touska F, Vetter I, Kistner K, Kichko TI, Teixeira NB, Picolo G, Cury Y, Lewis RJ, Fischer MJ, Zimmermann K, Reeh PW. Crotalphine desensitizes TRPA1 ion channels to alleviate inflammatory hyperalgesia. Pain. PMID 27434506 DOI: 10.1097/j.pain.0000000000000669  0.52
2016 Abraham N, Paul B, Ragnarsson L, Lewis RJ. Escherichia coli Protein Expression System for Acetylcholine Binding Proteins (AChBPs). Plos One. 11: e0157363. PMID 27304486 DOI: 10.1371/journal.pone.0157363  0.4
2016 Deuis JR, Dekan Z, Inserra MC, Lee TH, Aguilar MI, Craik DJ, Lewis RJ, Alewood PF, Mobli M, Schroeder CI, Henriques ST, Vetter I. Development of a μO-conotoxin Analogue with Improved Lipid Membrane Interactions and Potency for the Analgesic Target NaV1.8. The Journal of Biological Chemistry. PMID 27026701 DOI: 10.1074/jbc.M116.721662  0.56
2016 Deuis JR, Wingerd JS, Winter Z, Durek T, Dekan Z, Sousa SR, Zimmermann K, Hoffmann T, Weidner C, Nassar MA, Alewood PF, Lewis RJ, Vetter I. Analgesic Effects of GpTx-1, PF-04856264 and CNV1014802 in a Mouse Model of NaV1.7-Mediated Pain. Toxins. 8. PMID 26999206 DOI: 10.3390/toxins8030078  0.64
2016 Wan J, Brust A, Bhola RF, Jha P, Mobli M, Lewis RJ, Christie MJ, Alewood PF. Inhibition of the norepinephrine transporter by χ-conotoxin dendrimers. Journal of Peptide Science : An Official Publication of the European Peptide Society. PMID 26910400 DOI: 10.1002/psc.2857  0.64
2016 Brust A, Croker DE, Colless B, Ragnarsson L, Andersson A, Jain K, Caraballo SG, Castro J, Brierley SM, Alewood PF, Lewis RJ. Conopeptide-derived κ-opioid agonists (conorphins): potent, selective and metabolic stable dynorphinA mimetics with anti-nociceptive properties. Journal of Medicinal Chemistry. PMID 26859603 DOI: 10.1021/acs.jmedchem.5b00911  0.64
2015 Prashanth JR, Dutertre S, Jin AH, Lavergne V, Hamilton B, Cardoso FC, Griffin J, Venter DJ, Alewood PF, Lewis RJ. The role of defensive ecological interactions in the evolution of conotoxins. Molecular Ecology. PMID 26614983 DOI: 10.1111/mec.13504  0.64
2015 Le Garrec R, L'herondelle K, Le Gall-Ianotto C, Lebonvallet N, Leschiera R, Buhe V, Talagas M, Vetter I, Lewis RJ, Misery L. Release of neuropeptides from a neuro-cutaneous co-culture model: a novel in vitro model for studying sensory effects of ciguatoxins. Toxicon : Official Journal of the International Society On Toxinology. PMID 26562445 DOI: 10.1016/j.toxicon.2015.11.004  0.64
2015 Jin AH, Vetter I, Himaya SW, Alewood PF, Lewis RJ, Dutertre S. Transcriptome and proteome of Conus planorbis identify the nicotinic receptors as primary target for the defensive venom. Proteomics. PMID 26506909 DOI: 10.1002/pmic.201500220  0.64
2015 Patel R, Brice NL, Lewis RJ, Dickenson AH. Ionic Mechanisms of Spinal Neuronal Cold Hypersensitivity in Ciguatera. The European Journal of Neuroscience. PMID 26454262 DOI: 10.1111/ejn.13098  0.64
2015 Prashanth JR, Lewis RJ. An efficient transcriptome analysis pipeline to accelerate venom peptide discovery and characterisation. Toxicon : Official Journal of the International Society On Toxinology. PMID 26376071 DOI: 10.1016/j.toxicon.2015.09.012  0.64
2015 Himaya SW, Jin AH, Dutertre S, Giacomotto J, Mohialdeen H, Vetter I, Alewood PF, Lewis RJ. Comparative Venomics Reveals the Complex Prey Capture Strategy of the Piscivorous Cone Snail Conus catus. Journal of Proteome Research. 14: 4372-81. PMID 26322961 DOI: 10.1021/acs.jproteome.5b00630  0.64
2015 Deuis JR, Whately E, Brust A, Inserra MC, Asvadi NH, Lewis RJ, Alewood PF, Cabot PJ, Vetter I. Activation of κ Opioid Receptors in Cutaneous Nerve Endings by Conorphin-1, a Novel Subtype-Selective Conopeptide, Does Not Mediate Peripheral Analgesia. Acs Chemical Neuroscience. 6: 1751-8. PMID 26225903 DOI: 10.1021/acschemneuro.5b00113  0.64
2015 Jin AH, Israel MR, Inserra MC, Smith JJ, Lewis RJ, Alewood PF, Vetter I, Dutertre S. δ-Conotoxin SuVIA suggests an evolutionary link between ancestral predator defence and the origin of fish-hunting behaviour in carnivorous cone snails. Proceedings. Biological Sciences / the Royal Society. 282. PMID 26156767 DOI: 10.1098/rspb.2015.0817  0.64
2015 Rodriguez AM, Dutertre S, Lewis RJ, Marí F. Intraspecific variations in Conus purpurascens injected venom using LC/MALDI-TOF-MS and LC-ESI-TripleTOF-MS. Analytical and Bioanalytical Chemistry. 407: 6105-16. PMID 26048056 DOI: 10.1007/s00216-015-8787-y  0.64
2015 Cardoso FC, Dekan Z, Rosengren KJ, Erickson A, Vetter I, Deuis JR, Herzig V, Alewood PF, King GF, Lewis RJ. Identification and Characterization of ProTx-III [μ-TRTX-Tp1a], a New Voltage-Gated Sodium Channel Inhibitor from Venom of the Tarantula Thrixopelma pruriens. Molecular Pharmacology. 88: 291-303. PMID 25979003 DOI: 10.1124/mol.115.098178  0.64
2015 Gleeson EC, Graham JE, Spiller S, Vetter I, Lewis RJ, Duggan PJ, Tuck KL. Inhibition of N-type calcium channels by fluorophenoxyanilide derivatives. Marine Drugs. 13: 2030-45. PMID 25871286 DOI: 10.3390/md13042030  0.64
2015 Klint JK, Smith JJ, Vetter I, Rupasinghe DB, Er SY, Senff S, Herzig V, Mobli M, Lewis RJ, Bosmans F, King GF. Seven novel modulators of the analgesic target NaV 1.7 uncovered using a high-throughput venom-based discovery approach. British Journal of Pharmacology. 172: 2445-58. PMID 25754331 DOI: 10.1111/bph.13081  0.64
2015 Wan J, Huang JX, Vetter I, Mobli M, Lawson J, Tae HS, Abraham N, Paul B, Cooper MA, Adams DJ, Lewis RJ, Alewood PF. α-Conotoxin dendrimers have enhanced potency and selectivity for homomeric nicotinic acetylcholine receptors. Journal of the American Chemical Society. 137: 3209-12. PMID 25710197 DOI: 10.1021/jacs.5b00244  0.64
2015 Mueller A, Starobova H, Inserra MC, Jin AH, Deuis JR, Dutertre S, Lewis RJ, Alewood PF, Daly NL, Vetter I. α-Conotoxin MrIC is a biased agonist at α7 nicotinic acetylcholine receptors. Biochemical Pharmacology. 94: 155-63. PMID 25646788 DOI: 10.1016/j.bcp.2015.01.011  0.64
2015 Murali SS, Napier IA, Mohammadi SA, Alewood PF, Lewis RJ, Christie MJ. High-voltage-activated calcium current subtypes in mouse DRG neurons adapt in a subpopulation-specific manner after nerve injury. Journal of Neurophysiology. 113: 1511-9. PMID 25505111 DOI: 10.1152/jn.00608.2014  0.64
2015 Gori A, Wang CI, Harvey PJ, Rosengren KJ, Bhola RF, Gelmi ML, Longhi R, Christie MJ, Lewis RJ, Alewood PF, Brust A. Stabilization of the cysteine-rich conotoxin MrIA by using a 1,2,3-triazole as a disulfide bond mimetic. Angewandte Chemie (International Ed. in English). 54: 1361-4. PMID 25483297 DOI: 10.1002/anie.201409678  0.64
2015 Mollica A, Costante R, Novellino E, Stefanucci A, Pieretti S, Zador F, Samavati R, Borsodi A, Benyhe S, Vetter I, Lewis RJ. Design, Synthesis and Biological Evaluation of Two Opioid Agonist and Cav 2.2 Blocker Multitarget Ligands. Chemical Biology & Drug Design. 86: 156-62. PMID 25393330 DOI: 10.1111/cbdd.12479  0.64
2015 Ragnarsson L, Andersson Ã…, Thomas WG, Lewis RJ. Extracellular surface residues of the α1B-adrenoceptor critical for G protein-coupled receptor function. Molecular Pharmacology. 87: 121-9. PMID 25352041 DOI: 10.1124/mol.114.094557  0.64
2015 Yin K, Zimmermann K, Vetter I, Lewis RJ. Therapeutic opportunities for targeting cold pain pathways. Biochemical Pharmacology. 93: 125-40. PMID 25316567 DOI: 10.1016/j.bcp.2014.09.024  0.64
2015 Lewis RJ, Vetter I, Cardoso FC, Inserra M, King G. Does nature do ion channel drug discovery better than us? Rsc Drug Discovery Series. 2015: 297-319.  0.64
2015 Dutertre S, Undheim EAB, Pineda SS, Jin AH, Lavergne V, Fry BG, Lewis RJ, Alewood PF, King GF. Venoms-based drug discovery: Proteomic and transcriptomic approaches Rsc Drug Discovery Series. 2015: 80-96.  0.64
2015 Lewis RJ. Case Study 1: Development of the analgesic drugs prialt and Xen2174 from cone snail venoms Rsc Drug Discovery Series. 2015: 245-254.  0.64
2014 Prashanth JR, Brust A, Jin AH, Alewood PF, Dutertre S, Lewis RJ. Cone snail venomics: from novel biology to novel therapeutics. Future Medicinal Chemistry. 6: 1659-75. PMID 25406006 DOI: 10.4155/fmc.14.99  0.64
2014 Dutertre S, Jin AH, Alewood PF, Lewis RJ. Intraspecific variations in Conus geographus defence-evoked venom and estimation of the human lethal dose. Toxicon : Official Journal of the International Society On Toxinology. 91: 135-44. PMID 25301479 DOI: 10.1016/j.toxicon.2014.09.011  0.64
2014 Hopping G, Wang CI, Hogg RC, Nevin ST, Lewis RJ, Adams DJ, Alewood PF. Hydrophobic residues at position 10 of α-conotoxin PnIA influence subtype selectivity between α7 and α3β2 neuronal nicotinic acetylcholine receptors. Biochemical Pharmacology. 91: 534-42. PMID 25101833 DOI: 10.1016/j.bcp.2014.07.025  0.64
2014 Karas JA, Scanlon DB, Forbes BE, Vetter I, Lewis RJ, Gardiner J, Separovic F, Wade JD, Hossain MA. 2-nitroveratryl as a photocleavable thiol-protecting group for directed disulfide bond formation in the chemical synthesis of insulin. Chemistry (Weinheim An Der Bergstrasse, Germany). 20: 9549-52. PMID 24957739 DOI: 10.1002/chem.201403574  0.64
2014 L'herondelle K, Philippe R, Mignen O, Vetter I, Lewis RJ, Misery L, Le Garrec R. [In Process Citation]. Annales De Dermatologie Et De VéNéRéOlogie. 141: S90. PMID 24942436 DOI: 10.1016/j.annder.2014.04.154  0.52
2014 Wang CI, Reeks T, Vetter I, Vergara I, Kovtun O, Lewis RJ, Alewood PF, Durek T. Isolation and structural and pharmacological characterization of α-elapitoxin-Dpp2d, an amidated three finger toxin from black mamba venom. Biochemistry. 53: 3758-66. PMID 24867092 DOI: 10.1021/bi5004475  0.64
2014 Heus F, Otvos RA, Aspers RL, van Elk R, Halff JI, Ehlers AW, Dutertre S, Lewis RJ, Wijmenga S, Smit AB, Niessen WM, Kool J. Miniaturized bioaffinity assessment coupled to mass spectrometry for guided purification of bioactives from toad and cone snail. Biology. 3: 139-56. PMID 24833338 DOI: 10.3390/biology3010139  0.64
2014 Manger R, Woodle D, Berger A, Dickey RW, Jester E, Yasumoto T, Lewis R, Hawryluk T, Hungerford J. Flow cytometric-membrane potential detection of sodium channel active marine toxins: application to ciguatoxins in fish muscle and feasibility of automating saxitoxin detection. Journal of Aoac International. 97: 299-306. PMID 24830140 DOI: 10.5740/jaoacint.SGEManger  0.64
2014 Akondi KB, Muttenthaler M, Dutertre S, Kaas Q, Craik DJ, Lewis RJ, Alewood PF. Discovery, synthesis, and structure-activity relationships of conotoxins. Chemical Reviews. 114: 5815-47. PMID 24720541 DOI: 10.1021/cr400401e  0.64
2014 Deuis JR, Lim YL, Rodrigues de Sousa S, Lewis RJ, Alewood PF, Cabot PJ, Vetter I. Analgesic effects of clinically used compounds in novel mouse models of polyneuropathy induced by oxaliplatin and cisplatin. Neuro-Oncology. 16: 1324-32. PMID 24714523 DOI: 10.1093/neuonc/nou048  0.64
2014 Dutertre S, Jin AH, Vetter I, Hamilton B, Sunagar K, Lavergne V, Dutertre V, Fry BG, Antunes A, Venter DJ, Alewood PF, Lewis RJ. Evolution of separate predation- and defence-evoked venoms in carnivorous cone snails. Nature Communications. 5: 3521. PMID 24662800 DOI: 10.1038/ncomms4521  0.64
2014 de Araujo AD, Mobli M, Castro J, Harrington AM, Vetter I, Dekan Z, Muttenthaler M, Wan J, Lewis RJ, King GF, Brierley SM, Alewood PF. Selenoether oxytocin analogues have analgesic properties in a mouse model of chronic abdominal pain. Nature Communications. 5: 3165. PMID 24476666 DOI: 10.1038/ncomms4165  0.64
2014 Jin AH, Vetter I, Dutertre S, Abraham N, Emidio NB, Inserra M, Murali SS, Christie MJ, Alewood PF, Lewis RJ. MrIC, a novel α-conotoxin agonist in the presence of PNU at endogenous α7 nicotinic acetylcholine receptors. Biochemistry. 53: 1-3. PMID 24351107 DOI: 10.1021/bi400882s  0.64
2014 Akondi KB, Lewis RJ, Alewood PF. Re-engineering the μ-conotoxin SIIIA scaffold. Biopolymers. 101: 347-54. PMID 23913763 DOI: 10.1002/bip.22368  0.64
2014 Amade P, Mehiri M, Lewis RJ. Outstanding Marine Biotoxins: STX, TTX, and CTX Outstanding Marine Molecules: Chemistry, Biology, Analysis. 23-44. DOI: 10.1002/9783527681501.ch02  0.64
2013 Skinner MP, Lewis RJ, Morton S. Ecology of the ciguatera causing dinoflagellates from the Northern Great Barrier Reef: changes in community distribution and coastal eutrophication. Marine Pollution Bulletin. 77: 210-9. PMID 24210944 DOI: 10.1016/j.marpolbul.2013.10.003  0.64
2013 Sadeghi M, Murali SS, Lewis RJ, Alewood PF, Mohammadi S, Christie MJ. Novel ω-conotoxins from C. catus reverse signs of mouse inflammatory pain after systemic administration. Molecular Pain. 9: 51. PMID 24139484 DOI: 10.1186/1744-8069-9-51  0.64
2013 Vetter I, Hein A, Sattler S, Hessler S, Touska F, Bressan E, Parra A, Hager U, Leffler A, Boukalova S, Nissen M, Lewis RJ, Belmonte C, Alzheimer C, Huth T, et al. Amplified cold transduction in native nociceptors by M-channel inhibition. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 33: 16627-41. PMID 24133266 DOI: 10.1523/JNEUROSCI.1473-13.2013  0.64
2013 Lavergne V, Dutertre S, Jin AH, Lewis RJ, Taft RJ, Alewood PF. Systematic interrogation of the Conus marmoreus venom duct transcriptome with ConoSorter reveals 158 novel conotoxins and 13 new gene superfamilies. Bmc Genomics. 14: 708. PMID 24131469 DOI: 10.1186/1471-2164-14-708  0.64
2013 Brust A, Wang CI, Daly NL, Kennerly J, Sadeghi M, Christie MJ, Lewis RJ, Mobli M, Alewood PF. Vicinal disulfide constrained cyclic peptidomimetics: a turn mimetic scaffold targeting the norepinephrine transporter. Angewandte Chemie (International Ed. in English). 52: 12020-3. PMID 24115503 DOI: 10.1002/anie.201304660  0.64
2013 Jin AH, Dutertre S, Kaas Q, Lavergne V, Kubala P, Lewis RJ, Alewood PF. Transcriptomic messiness in the venom duct of Conus miles contributes to conotoxin diversity. Molecular & Cellular Proteomics : McP. 12: 3824-33. PMID 24043424 DOI: 10.1074/mcp.M113.030353  0.64
2013 Inserra MC, Kompella SN, Vetter I, Brust A, Daly NL, Cuny H, Craik DJ, Alewood PF, Adams DJ, Lewis RJ. Isolation and characterization of α-conotoxin LsIA with potent activity at nicotinic acetylcholine receptors. Biochemical Pharmacology. 86: 791-9. PMID 23924607 DOI: 10.1016/j.bcp.2013.07.016  0.64
2013 Zimmermann K, Deuis JR, Inserra MC, Collins LS, Namer B, Cabot PJ, Reeh PW, Lewis RJ, Vetter I. Analgesic treatment of ciguatoxin-induced cold allodynia. Pain. 154: 1999-2006. PMID 23778293 DOI: 10.1016/j.pain.2013.06.015  0.64
2013 Jayamanne A, Jeong HJ, Schroeder CI, Lewis RJ, Christie MJ, Vaughan CW. Spinal actions of ω-conotoxins, CVID, MVIIA and related peptides in a rat neuropathic pain model. British Journal of Pharmacology. 170: 245-54. PMID 23713957 DOI: 10.1111/bph.12251  0.64
2013 Deuis JR, Zimmermann K, Romanovsky AA, Possani LD, Cabot PJ, Lewis RJ, Vetter I. An animal model of oxaliplatin-induced cold allodynia reveals a crucial role for Nav1.6 in peripheral pain pathways. Pain. 154: 1749-57. PMID 23711479 DOI: 10.1016/j.pain.2013.05.032  0.64
2013 Smith JJ, Vetter I, Lewis RJ, Peigneur S, Tytgat J, Lam A, Gallant EM, Beard NA, Alewood PF, Dulhunty AF. Multiple actions of phi-LITX-Lw1a on ryanodine receptors reveal a functional link between scorpion DDH and ICK toxins. Proceedings of the National Academy of Sciences of the United States of America. 110: 8906-11. PMID 23671114 DOI: 10.1073/pnas.1214062110  0.64
2013 Sousa SR, Vetter I, Ragnarsson L, Lewis RJ. Expression and pharmacology of endogenous Cav channels in SH-SY5Y human neuroblastoma cells. Plos One. 8: e59293. PMID 23536870 DOI: 10.1371/journal.pone.0059293  0.64
2013 Durek T, Vetter I, Wang CI, Motin L, Knapp O, Adams DJ, Lewis RJ, Alewood PF. Chemical engineering and structural and pharmacological characterization of the α-scorpion toxin OD1. Acs Chemical Biology. 8: 1215-22. PMID 23527544 DOI: 10.1021/cb400012k  0.64
2013 Ghassemian A, Wang CI, Yau MK, Reid RC, Lewis RJ, Fairlie DP, Alewood PF, Durek T. Efficient chemical synthesis of human complement protein C3a. Chemical Communications (Cambridge, England). 49: 2356-8. PMID 23407800 DOI: 10.1039/c3cc40537k  0.64
2013 Sousa SR, Vetter I, Lewis RJ. Venom peptides as a rich source of cav2.2 channel blockers. Toxins. 5: 286-314. PMID 23381143 DOI: 10.3390/toxins5020286  0.64
2013 Brust A, Sunagar K, Undheim EA, Vetter I, Yang DC, Yang DC, Casewell NR, Jackson TN, Koludarov I, Alewood PF, Hodgson WC, Lewis RJ, King GF, Antunes A, Hendrikx I, et al. Differential evolution and neofunctionalization of snake venom metalloprotease domains. Molecular & Cellular Proteomics : McP. 12: 651-63. PMID 23242553 DOI: 10.1074/mcp.M112.023135  0.64
2013 Ragnarsson L, Wang CI, Andersson Ã…, Fajarningsih D, Monks T, Brust A, Rosengren KJ, Lewis RJ. Conopeptide ρ-TIA defines a new allosteric site on the extracellular surface of the α1B-adrenoceptor. The Journal of Biological Chemistry. 288: 1814-27. PMID 23184947 DOI: 10.1074/jbc.M112.430785  0.64
2013 Dutertre S, Jin AH, Kaas Q, Jones A, Alewood PF, Lewis RJ. Deep venomics reveals the mechanism for expanded peptide diversity in cone snail venom. Molecular & Cellular Proteomics : McP. 12: 312-29. PMID 23152539 DOI: 10.1074/mcp.M112.021469  0.64
2013 Wang CI, Lewis RJ. Emerging opportunities for allosteric modulation of G-protein coupled receptors. Biochemical Pharmacology. 85: 153-62. PMID 22975406 DOI: 10.1016/j.bcp.2012.09.001  0.64
2013 Brust A, Sunagar K, Undheim EAB, Vetter I, Yang DC, Casewell NR, Jackson TNW, Koludarov I, Alewood PF, Hodgson WC, Lewis RJ, King GF, Antunes A, Hendrikx I, Fry BG. Differential evolution and neofunctionalization of snake venom metalloprotease domains (Molecular and Cellular Proteomics 2013, 12, (651-663)) Molecular and Cellular Proteomics. 12: 1488. DOI: 10.1074/mcp.A112.023135  0.64
2013 Dutertre S, Lewis RJ. Cone snail biology, bioprospecting and conservation Snails: Biology, Ecology and Conservation. 85-104.  0.64
2012 Schroeder CI, Nielsen KJ, Adams DA, Loughnan M, Thomas L, Alewood PF, Lewis RJ, Craik DJ. Effects of Lys2 to Ala2 substitutions on the structure and potency of ω-conotoxins MVIIA and CVID. Biopolymers. 98: 345-56. PMID 23193599  0.64
2012 Tranberg CE, Yang A, Vetter I, McArthur JR, Baell JB, Lewis RJ, Tuck KL, Duggan PJ. ω-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca(v)2.2 ion channels. Marine Drugs. 10: 2349-68. PMID 23170089 DOI: 10.3390/md10102349  0.64
2012 Wang CI, Shaikh NH, Ramu S, Lewis RJ. A second extracellular site is required for norepinephrine transport by the human norepinephrine transporter. Molecular Pharmacology. 82: 898-909. PMID 22874414 DOI: 10.1124/mol.112.080630  0.64
2012 Vetter I, Touska F, Hess A, Hinsbey R, Sattler S, Lampert A, Sergejeva M, Sharov A, Collins LS, Eberhardt M, Engel M, Cabot PJ, Wood JN, Vlachová V, Reeh PW, ... Lewis RJ, et al. Ciguatoxins activate specific cold pain pathways to elicit burning pain from cooling. The Embo Journal. 31: 3795-808. PMID 22850668 DOI: 10.1038/emboj.2012.207  0.64
2012 Vetter I, Lewis RJ. Therapeutic potential of cone snail venom peptides (conopeptides). Current Topics in Medicinal Chemistry. 12: 1546-52. PMID 22827523 DOI: 10.2174/156802612802652457  0.64
2012 Marcon F, Leblanc M, Vetter I, Lewis RJ, Escoubas P, Nicholson GM. Pharmacological characterization of α-elapitoxin-Al2a from the venom of the Australian pygmy copperhead (Austrelaps labialis): an atypical long-chain α-neurotoxin with only weak affinity for α7 nicotinic receptors. Biochemical Pharmacology. 84: 851-63. PMID 22771828 DOI: 10.1016/j.bcp.2012.06.024  0.64
2012 Schroeder CI, Adams D, Thomas L, Alewood PF, Lewis RJ. N- and C-terminal extensions of μ-conotoxins increase potency and selectivity for neuronal sodium channels. Biopolymers. 98: 161-5. PMID 22733528 DOI: 10.1002/bip.22032  0.64
2012 Vetter I, Dekan Z, Knapp O, Adams DJ, Alewood PF, Lewis RJ. Isolation, characterization and total regioselective synthesis of the novel μO-conotoxin MfVIA from Conus magnificus that targets voltage-gated sodium channels. Biochemical Pharmacology. 84: 540-8. PMID 22609441 DOI: 10.1016/j.bcp.2012.05.008  0.64
2012 Dekan Z, Wang CI, Andrews RK, Lewis RJ, Alewood PF. Conotoxin engineering: dual pharmacophoric noradrenaline transport inhibitor/integrin binding peptide with improved stability. Organic & Biomolecular Chemistry. 10: 5791-4. PMID 22581211 DOI: 10.1039/c2ob25133g  0.64
2012 Prashanth JR, Lewis RJ, Dutertre S. Towards an integrated venomics approach for accelerated conopeptide discovery. Toxicon : Official Journal of the International Society On Toxinology. 60: 470-7. PMID 22564717 DOI: 10.1016/j.toxicon.2012.04.340  0.64
2012 Knapp O, Nevin ST, Yasuda T, Lawrence N, Lewis RJ, Adams DJ. Biophysical properties of Na(v) 1.8/Na(v) 1.2 chimeras and inhibition by µO-conotoxin MrVIB. British Journal of Pharmacology. 166: 2148-60. PMID 22452751 DOI: 10.1111/j.1476-5381.2012.01955.x  0.64
2012 Vetter I, Mozar CA, Durek T, Wingerd JS, Alewood PF, Christie MJ, Lewis RJ. Characterisation of Na(v) types endogenously expressed in human SH-SY5Y neuroblastoma cells. Biochemical Pharmacology. 83: 1562-71. PMID 22410003 DOI: 10.1016/j.bcp.2012.02.022  0.64
2012 Lewis RJ, Dutertre S, Vetter I, Christie MJ. Conus venom peptide pharmacology. Pharmacological Reviews. 64: 259-98. PMID 22407615 DOI: 10.1124/pr.111.005322  0.64
2012 Lewis RJ. Discovery and development of the χ-conopeptide class of analgesic peptides. Toxicon : Official Journal of the International Society On Toxinology. 59: 524-8. PMID 21839105 DOI: 10.1016/j.toxicon.2011.07.012  0.64
2012 Wingerd JS, Vetter I, Lewis RJ. Voltage-Gated Sodium Channels as Therapeutic Targets Therapeutic Targets: Modulation, Inhibition, and Activation. 63-122. DOI: 10.1002/9781118185537.ch3  0.64
2012 Muttenthaler M, Walton H, Dutertre S, Wingerd JS, Alewood PF, Lewis RJ, Aini JW. Abundance and diversity of Conus species (gastropoda: Conidae) at the northern tip of New Ireland province of Papua New Guinea Nautilus. 126: 47-56.  0.64
2011 Skinner MP, Brewer TD, Johnstone R, Fleming LE, Lewis RJ. Ciguatera fish poisoning in the Pacific Islands (1998 to 2008). Plos Neglected Tropical Diseases. 5: e1416. PMID 22180797 DOI: 10.1371/journal.pntd.0001416  0.64
2011 Dekan Z, Vetter I, Daly NL, Craik DJ, Lewis RJ, Alewood PF. α-Conotoxin ImI incorporating stable cystathionine bridges maintains full potency and identical three-dimensional structure. Journal of the American Chemical Society. 133: 15866-9. PMID 21899353 DOI: 10.1021/ja206408q  0.64
2011 Inserra MC, Lewis RJ. Venom Peptide modulators of the immune system. Inflammation & Allergy Drug Targets. 10: 399-410. PMID 21824080  0.64
2011 Vetter I, Lewis RJ. Natural product ligands of TRP channels. Advances in Experimental Medicine and Biology. 704: 41-85. PMID 21290289 DOI: 10.1007/978-94-007-0265-3_3  0.64
2011 Vetter I, Davis JL, Rash LD, Anangi R, Mobli M, Alewood PF, Lewis RJ, King GF. Venomics: A new paradigm for natural products-based drug discovery Amino Acids. 40: 15-28. PMID 20177945 DOI: 10.1007/s00726-010-0516-4  0.64
2010 Muttenthaler M, Andersson A, de Araujo AD, Dekan Z, Lewis RJ, Alewood PF. Modulating oxytocin activity and plasma stability by disulfide bond engineering. Journal of Medicinal Chemistry. 53: 8585-96. PMID 21117646 DOI: 10.1021/jm100989w  0.64
2010 Stewart I, Lewis RJ, Eaglesham GK, Graham GC, Poole S, Craig SB. Emerging tropical diseases in Australia. Part 2. Ciguatera fish poisoning. Annals of Tropical Medicine and Parasitology. 104: 557-71. PMID 21092393 DOI: 10.1179/136485910X12851868779902  0.64
2010 Morales RA, Daly NL, Vetter I, Mobli M, Napier IA, Craik DJ, Lewis RJ, Christie MJ, King GF, Alewood PF, Durek T. Chemical synthesis and structure of the prokineticin Bv8. Chembiochem : a European Journal of Chemical Biology. 11: 1882-8. PMID 20677202 DOI: 10.1002/cbic.201000330  0.64
2010 Lewis RJ, Poli M. Editorial: Toxins in seafood Toxicon. 56: 107. PMID 20510727 DOI: 10.1016/j.toxicon.2010.05.002  0.64
2010 Grishin AA, Wang CI, Muttenthaler M, Alewood PF, Lewis RJ, Adams DJ. Alpha-conotoxin AuIB isomers exhibit distinct inhibitory mechanisms and differential sensitivity to stoichiometry of alpha3beta4 nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 285: 22254-63. PMID 20466726 DOI: 10.1074/jbc.M110.111880  0.64
2010 Dutertre S, Lewis RJ. Use of venom peptides to probe ion channel structure and function Journal of Biological Chemistry. 285: 13315-13320. PMID 20189991 DOI: 10.1074/jbc.R109.076596  0.64
2010 Muttenthaler M, Nevin ST, Grishin AA, Ngo ST, Choy PT, Daly NL, Hu SH, Armishaw CJ, Wang CI, Lewis RJ, Martin JL, Noakes PG, Craik DJ, Adams DJ, Alewood PF. Solving the alpha-conotoxin folding problem: efficient selenium-directed on-resin generation of more potent and stable nicotinic acetylcholine receptor antagonists. Journal of the American Chemical Society. 132: 3514-22. PMID 20163143 DOI: 10.1021/ja910602h  0.64
2010 Luo S, Akondi KB, Zhangsun D, Wu Y, Zhu X, Hu Y, Christensen S, Dowell C, Daly NL, Craik DJ, Wang CIA, Lewis RJ, Alewood PF, McIntosh JM. Atypical α-conotoxin LtIA from Conus litteratus targets a novel microsite of the α3β2 nicotinic receptor Journal of Biological Chemistry. 285: 12355-12366. PMID 20145249 DOI: 10.1074/jbc.M109.079012  0.64
2010 Wang CIA, Lewis RJ. Emerging structure-function relationships defining monoamine NSS transporter substrate and ligand affinity Biochemical Pharmacology. 79: 1083-1091. PMID 19954741 DOI: 10.1016/j.bcp.2009.11.019  0.64
2010 Berecki G, Motin L, Haythornthwaite A, Vink S, Bansal P, Drinkwater R, Wang CI, Moretta M, Lewis RJ, Alewood PF, Christie MJ, Adams DJ. Analgesic (omega)-conotoxins CVIE and CVIF selectively and voltage-dependently block recombinant and native N-type calcium channels. Molecular Pharmacology. 77: 139-48. PMID 19892914 DOI: 10.1124/mol.109.058834  0.64
2010 Vetter I, Lewis RJ. Characterization of endogenous calcium responses in neuronal cell lines Biochemical Pharmacology. 79: 908-920. PMID 19883631 DOI: 10.1016/j.bcp.2009.10.020  0.64
2010 Nguyen-Huu TD, Mattei C, Wen PJ, Bourdelais AJ, Lewis RJ, Benoit E, Baden DG, Molgó J, Meunier FA. Ciguatoxin-induced catecholamine secretion in bovine chromaffin cells: Mechanism of action and reversible inhibition by brevenal Toxicon. 56: 792-796. PMID 19682481 DOI: 10.1016/j.toxicon.2009.08.002  0.64
2010 Mattei C, Marquais M, Schlumberger S, Molgó J, Vernoux JP, Lewis RJ, Benoit E. Analysis of Caribbean ciguatoxin-1 effects on frog myelinated axons and the neuromuscular junction Toxicon. 56: 759-767. PMID 19646468 DOI: 10.1016/j.toxicon.2009.07.026  0.64
2010 Hamilton B, Whittle N, Shaw G, Eaglesham G, Moore MR, Lewis RJ. Human fatality associated with Pacific ciguatoxin contaminated fish. Toxicon : Official Journal of the International Society On Toxinology. 56: 668-73. PMID 19538985 DOI: 10.1016/j.toxicon.2009.06.007  0.64
2009 Lewis RJ. Conotoxin venom peptide therapeutics Advances in Experimental Medicine and Biology. 655: 44-48. PMID 20047034 DOI: 10.1007/978-1-4419-1132-2_5  0.64
2009 Brust A, Palant E, Croker DE, Colless B, Drinkwater R, Patterson B, Schroeder CI, Wilson D, Nielsen CK, Smith MT, Alewood D, Alewood PF, Lewis RJ. chi-Conopeptide pharmacophore development: toward a novel class of norepinephrine transporter inhibitor (Xen2174) for pain. Journal of Medicinal Chemistry. 52: 6991-7002. PMID 19860431 DOI: 10.1021/jm9003413  0.64
2009 Yang X, Molimau S, Doherty GP, Johnston EB, Marles-Wright J, Rothnagel R, Hankamer B, Lewis RJ, Lewis PJ. The structure of bacterial RNA polymerase in complex with the essential transcription elongation factor NusA. Embo Reports. 10: 997-1002. PMID 19680289 DOI: 10.1038/embor.2009.155  0.64
2009 Davis J, Jones A, Lewis RJ. Remarkable inter- and intra-species complexity of conotoxins revealed by LC/MS. Peptides. 30: 1222-7. PMID 19540420 DOI: 10.1016/j.peptides.2009.03.019  0.4
2009 Loughnan ML, Nicke A, Lawrence N, Lewis RJ. Novel alpha D-conopeptides and their precursors identified by cDNA cloning define the D-conotoxin superfamily. Biochemistry. 48: 3717-29. PMID 19275168 DOI: 10.1021/bi9000326  0.84
2009 Millard EL, Nevin ST, Loughnan ML, Nicke A, Clark RJ, Alewood PF, Lewis RJ, Adams DJ, Craik DJ, Daly NL. Inhibition of neuronal nicotinic acetylcholine receptor subtypes by alpha-Conotoxin GID and analogues. The Journal of Biological Chemistry. 284: 4944-51. PMID 19098004 DOI: 10.1074/jbc.M804950200  0.64
2009 Hopping G, Lewis RJ, Alewood PF. Rapid access to ω-conotoxin chimeras using native chemical ligation Australian Journal of Chemistry. 62: 1333-1338. DOI: 10.1071/CH09216  0.64
2008 Jin AH, Daly NL, Nevin ST, Wang CI, Dutertre S, Lewis RJ, Adams DJ, Craik DJ, Alewood PF. Molecular engineering of conotoxins: the importance of loop size to alpha-conotoxin structure and function. Journal of Medicinal Chemistry. 51: 5575-84. PMID 18754612 DOI: 10.1021/jm800278k  0.64
2008 Schroeder CI, Ekberg J, Nielsen KJ, Adams D, Loughnan ML, Thomas L, Adams DJ, Alewood PF, Lewis RJ. Neuronally micro-conotoxins from Conus striatus utilize an alpha-helical motif to target mammalian sodium channels. The Journal of Biological Chemistry. 283: 21621-8. PMID 18522941 DOI: 10.1074/jbc.M802852200  0.64
2008 Dutertre S, Croker D, Daly NL, Andersson A, Muttenthaler M, Lumsden NG, Craik DJ, Alewood PF, Guillon G, Lewis RJ. Conopressin-T from Conus tulipa reveals an antagonist switch in vasopressin-like peptides. The Journal of Biological Chemistry. 283: 7100-8. PMID 18174156 DOI: 10.1074/jbc.M706477200  0.56
2007 Paczkowski FA, Sharpe IA, Dutertre S, Lewis RJ. chi-Conotoxin and tricyclic antidepressant interactions at the norepinephrine transporter define a new transporter model. The Journal of Biological Chemistry. 282: 17837-44. PMID 17428804 DOI: 10.1074/jbc.M610813200  0.64
2007 Motin L, Yasuda T, Schroeder CI, Lewis RJ, Adams DJ. Omega-conotoxin CVIB differentially inhibits native and recombinant N- and P/Q-type calcium channels. The European Journal of Neuroscience. 25: 435-44. PMID 17284184 DOI: 10.1111/j.1460-9568.2006.05299.x  0.64
2007 Lewis RJ, Schroeder CI, Ekberg J, Nielsen KJ, Loughnan M, Thomas L, Adams DA, Drinkwater R, Adams DJ, Alewood PF. Isolation and structure-activity of mu-conotoxin TIIIA, a potent inhibitor of tetrodotoxin-sensitive voltage-gated sodium channels. Molecular Pharmacology. 71: 676-85. PMID 17142296 DOI: 10.1124/mol.106.028225  0.64
2006 Ekberg J, Jayamanne A, Vaughan CW, Aslan S, Thomas L, Mould J, Drinkwater R, Baker MD, Abrahamsen B, Wood JN, Adams DJ, Christie MJ, Lewis RJ. muO-conotoxin MrVIB selectively blocks Nav1.8 sensory neuron specific sodium channels and chronic pain behavior without motor deficits. Proceedings of the National Academy of Sciences of the United States of America. 103: 17030-5. PMID 17077153 DOI: 10.1073/pnas.0601819103  0.64
2006 St Pierre L, Flight S, Masci PP, Hanchard KJ, Lewis RJ, Alewood PF, de Jersey J, Lavin MF. Cloning and characterisation of natriuretic peptides from the venom glands of Australian elapids. Biochimie. 88: 1923-31. PMID 16908092 DOI: 10.1016/j.biochi.2006.06.014  0.64
2006 Loughnan M, Nicke A, Jones A, Schroeder CI, Nevin ST, Adams DJ, Alewood PF, Lewis RJ. Identification of a novel class of nicotinic receptor antagonists: dimeric conotoxins VxXIIA, VxXIIB, and VxXIIC from Conus vexillum. The Journal of Biological Chemistry. 281: 24745-55. PMID 16790424 DOI: 10.1074/jbc.M603703200  0.64
2006 Ragnarsson L, Yasuda T, Lewis RJ, Dodd PR, Adams DJ. NMDA receptor subunit-dependent modulation by conantokin-G and Ala7-conantokin-G. Journal of Neurochemistry. 96: 283-91. PMID 16336218 DOI: 10.1111/j.1471-4159.2005.03574.x  0.64
2005 Nilsson KP, Lovelace ES, Caesar CE, TynngÃ¥rd N, Alewood PF, Johansson HM, Sharpe IA, Lewis RJ, Daly NL, Craik DJ. Solution structure of chi-conopeptide MrIA, a modulator of the human norepinephrine transporter. Biopolymers. 80: 815-23. PMID 15931669 DOI: 10.1002/bip.20302  0.64
2005 Dutertre S, Nicke A, Lewis RJ. Beta2 subunit contribution to 4/7 alpha-conotoxin binding to the nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 280: 30460-8. PMID 15929983 DOI: 10.1074/jbc.M504229200  0.84
2004 Yasuda T, Chen L, Barr W, McRory JE, Lewis RJ, Adams DJ, Zamponi GW. Auxiliary subunit regulation of high-voltage activated calcium channels expressed in mammalian cells. The European Journal of Neuroscience. 20: 1-13. PMID 15245474 DOI: 10.1111/j.1460-9568.2004.03434.x  0.64
2004 Mould J, Yasuda T, Schroeder CI, Beedle AM, Doering CJ, Zamponi GW, Adams DJ, Lewis RJ. The alpha2delta auxiliary subunit reduces affinity of omega-conotoxins for recombinant N-type (Cav2.2) calcium channels. The Journal of Biological Chemistry. 279: 34705-14. PMID 15166237 DOI: 10.1074/jbc.M310848200  0.64
2004 Kloda A, Clements JD, Lewis RJ, Adams DJ. Adenosine triphosphate acts as both a competitive antagonist and a positive allosteric modulator at recombinant N-methyl-D-aspartate receptors. Molecular Pharmacology. 65: 1386-96. PMID 15155832 DOI: 10.1124/mol.65.6.1386  0.64
2004 Daly NL, Ekberg JA, Thomas L, Adams DJ, Lewis RJ, Craik DJ. Structures of muO-conotoxins from Conus marmoreus. I nhibitors of tetrodotoxin (TTX)-sensitive and TTX-resistant sodium channels in mammalian sensory neurons. The Journal of Biological Chemistry. 279: 25774-82. PMID 15044438 DOI: 10.1074/jbc.M313002200  0.64
2004 Yasuda T, Lewis RJ, Adams DJ. Overexpressed Ca(v)beta3 inhibits N-type (Cav2.2) calcium channel currents through a hyperpolarizing shift of ultra-slow and closed-state inactivation. The Journal of General Physiology. 123: 401-16. PMID 15024042 DOI: 10.1085/jgp.200308967  0.64
2004 Loughnan ML, Nicke A, Jones A, Adams DJ, Alewood PF, Lewis RJ. Chemical and functional identification and characterization of novel sulfated alpha-conotoxins from the cone snail Conus anemone. Journal of Medicinal Chemistry. 47: 1234-41. PMID 14971903 DOI: 10.1021/jm031010o  0.64
2003 Sharpe IA, Palant E, Schroeder CI, Kaye DM, Adams DJ, Alewood PF, Lewis RJ. Inhibition of the norepinephrine transporter by the venom peptide chi-MrIA. Site of action, Na+ dependence, and structure-activity relationship. The Journal of Biological Chemistry. 278: 40317-23. PMID 12885787 DOI: 10.1074/jbc.M213030200  0.64
2003 Sharpe IA, Thomas L, Loughnan M, Motin L, Palant E, Croker DE, Alewood D, Chen S, Graham RM, Alewood PF, Adams DJ, Lewis RJ. Allosteric alpha 1-adrenoreceptor antagonism by the conopeptide rho-TIA. The Journal of Biological Chemistry. 278: 34451-7. PMID 12824165 DOI: 10.1074/jbc.M305410200  0.64
2003 Blanchfield JT, Dutton JL, Hogg RC, Gallagher OP, Craik DJ, Jones A, Adams DJ, Lewis RJ, Alewood PF, Toth I. Synthesis, structure elucidation, in vitro biological activity, toxicity, and Caco-2 cell permeability of lipophilic analogues of alpha-conotoxin MII. Journal of Medicinal Chemistry. 46: 1266-72. PMID 12646037 DOI: 10.1021/jm020426j  0.64
2003 Adams DJ, Smith AB, Schroeder CI, Yasuda T, Lewis RJ. Omega-conotoxin CVID inhibits a pharmacologically distinct voltage-sensitive calcium channel associated with transmitter release from preganglionic nerve terminals. The Journal of Biological Chemistry. 278: 4057-62. PMID 12441339 DOI: 10.1074/jbc.M209969200  0.64
2003 Nicke A, Loughnan ML, Millard EL, Alewood PF, Adams DJ, Daly NL, Craik DJ, Lewis RJ. Isolation, structure, and activity of GID, a novel alpha 4/7-conotoxin with an extended N-terminal sequence. The Journal of Biological Chemistry. 278: 3137-44. PMID 12419800 DOI: 10.1074/jbc.M210280200  0.88
2002 Pottier I, Vernoux JP, Jones A, Lewis RJ. Analysis of toxin profiles in three different fish species causing ciguatera fish poisoning in Guadeloupe, French West Indies. Food Additives and Contaminants. 19: 1034-42. PMID 12456274 DOI: 10.1080/02652030210155378  0.4
2002 Hogg RC, Lewis RJ, Adams DJ. Ciguatoxin-induced oscillations in membrane potential and action potential firing in rat parasympathetic neurons. The European Journal of Neuroscience. 16: 242-8. PMID 12169106  0.88
2002 Nielsen KJ, Watson M, Adams DJ, Hammarström AK, Gage PW, Hill JM, Craik DJ, Thomas L, Adams D, Alewood PF, Lewis RJ. Solution structure of mu-conotoxin PIIIA, a preferential inhibitor of persistent tetrodotoxin-sensitive sodium channels. The Journal of Biological Chemistry. 277: 27247-55. PMID 12006587 DOI: 10.1074/jbc.M201611200  0.64
2001 Sharpe IA, Gehrmann J, Loughnan ML, Thomas L, Adams DA, Atkins A, Palant E, Craik DJ, Adams DJ, Alewood PF, Lewis RJ. Two new classes of conopeptides inhibit the alpha1-adrenoceptor and noradrenaline transporter. Nature Neuroscience. 4: 902-7. PMID 11528421 DOI: 10.1038/nn0901-902  0.64
2000 Lewis RJ, Nielsen KJ, Craik DJ, Loughnan ML, Adams DA, Sharpe IA, Luchian T, Adams DJ, Bond T, Thomas L, Jones A, Matheson JL, Drinkwater R, Andrews PR, Alewood PF. Novel omega-conotoxins from Conus catus discriminate among neuronal calcium channel subtypes. The Journal of Biological Chemistry. 275: 35335-44. PMID 10938268 DOI: 10.1074/jbc.M002252200  0.64
2000 Hill JM, Atkins AR, Loughnan ML, Jones A, Adams DA, Martin RC, Lewis RJ, Craik DJ, Alewood PF. Conotoxin TVIIA, a novel peptide from the venom of Conus tulipa 1. Isolation, characterization and chemical synthesis. European Journal of Biochemistry / Febs. 267: 4642-8. PMID 10903496 DOI: 10.1046/j.1432-1327.2000.01508.x  0.64
1999 Hogg RC, Miranda LP, Craik DJ, Lewis RJ, Alewood PF, Adams DJ. Single amino acid substitutions in alpha-conotoxin PnIA shift selectivity for subtypes of the mammalian neuronal nicotinic acetylcholine receptor. The Journal of Biological Chemistry. 274: 36559-64. PMID 10593955  0.88
1999 Nielsen KJ, Adams D, Thomas L, Bond T, Alewood PF, Craik DJ, Lewis RJ. Structure-activity relationships of omega-conotoxins MVIIA, MVIIC and 14 loop splice hybrids at N and P/Q-type calcium channels. Journal of Molecular Biology. 289: 1405-21. PMID 10373375 DOI: 10.1006/jmbi.1999.2817  0.52
1999 Nielsen KJ, Adams DA, Alewood PF, Lewis RJ, Thomas L, Schroeder T, Craik DJ. Effects of chirality at Tyr13 on the structure-activity relationships of omega-conotoxins from Conus magus. Biochemistry. 38: 6741-51. PMID 10346894 DOI: 10.1021/bi982980u  0.64
1999 Nielsen KJ, Skjaerbaek N, Dooley M, Adams DA, Mortensen M, Dodd PR, Craik DJ, Alewood PF, Lewis RJ. Structure-activity studies of conantokins as human N-methyl-D-aspartate receptor modulators. Journal of Medicinal Chemistry. 42: 415-26. PMID 9986713 DOI: 10.1021/jm981052q  0.64
1998 Hogg RC, Lewis RJ, Adams DJ. Ciguatoxin (CTX-1) modulates single tetrodotoxin-sensitive sodium channels in rat parasympathetic neurones. Neuroscience Letters. 252: 103-6. PMID 9756332  0.88
1998 Loughnan M, Bond T, Atkins A, Cuevas J, Adams DJ, Broxton NM, Livett BG, Down JG, Jones A, Alewood PF, Lewis RJ. alpha-conotoxin EpI, a novel sulfated peptide from Conus episcopatus that selectively targets neuronal nicotinic acetylcholine receptors. The Journal of Biological Chemistry. 273: 15667-74. PMID 9624161 DOI: 10.1074/jbc.273.25.15667  0.64
1997 Skjaerbaek N, Nielsen KJ, Lewis RJ, Alewood P, Craik DJ. Determination of the solution structures of conantokin-G and conantokin-T by CD and NMR spectroscopy. The Journal of Biological Chemistry. 272: 2291-9. PMID 8999936 DOI: 10.1074/jbc.272.4.2291  0.48
1996 Nielsen KJ, Thomas L, Lewis RJ, Alewood PF, Craik DJ. A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202. Journal of Molecular Biology. 263: 297-310. PMID 8913308 DOI: 10.1006/jmbi.1996.0576  0.52
1996 Jones A, Bingham JP, Gehrmann J, Bond T, Loughnan M, Atkins A, Lewis RJ, Alewood PF. Isolation and characterization of conopeptides by high-performance liquid chromatography combined with mass spectrometry and tandem mass spectrometry. Rapid Communications in Mass Spectrometry : Rcm. 10: 138-43. PMID 8563013 DOI: 10.1002/(SICI)1097-0231(19960115)10:1<138::AID-RCM442>3.0.CO;2-3  0.64
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