| Year |
Citation |
Score |
| 2022 |
Mitsui K, Lie MEK, Saito N, Fujiwara K, Watanabe M, Wellendorph P, Shuto S. Synthesis of γ-Aminobutyric Acid (GABA) Analogues Conformationally Restricted by Bicyclo[3.1.0]hexane/hexene or [4.1.0]Heptane/heptene Backbones as Potent Betaine/GABA Transporter Inhibitors. Organic Letters. 24: 4151-4154. PMID 35674784 DOI: 10.1021/acs.orglett.2c01346 |
0.328 |
|
| 2022 |
Khumpirapang N, Suknuntha K, Wongrattanakamon P, Jiranusornkul S, Anuchapreeda S, Wellendorph P, Müllertz A, Rades T, Okonogi S. The Binding of Oil and Its Nanoemulsion to Mammal GABA Receptors Using Rat Cortical Membranes and an In Silico Modeling Platform. Pharmaceutics. 14. PMID 35336025 DOI: 10.3390/pharmaceutics14030650 |
0.387 |
|
| 2021 |
Bavo F, de-Jong H, Petersen J, Falk-Petersen CB, Löffler R, Sparrow E, Rostrup F, Eliasen JN, Wilhelmsen KS, Barslund K, Bundgaard C, Nielsen B, Kristiansen U, Wellendorph P, Bogdanov Y, et al. Structure-Activity Studies of 3,9-Diazaspiro[5.5]undecane-Based γ-Aminobutyric Acid Type A Receptor Antagonists with Immunomodulatory Effect. Journal of Medicinal Chemistry. PMID 34908407 DOI: 10.1021/acs.jmedchem.1c00290 |
0.398 |
|
| 2021 |
Kickinger S, Lie MEK, Suemasa A, Al-Khawaja A, Fujiwara K, Watanabe M, Wilhelmsen KS, Falk-Petersen CB, Frølund B, Shuto S, Ecker GF, Wellendorph P. Molecular Determinants and Pharmacological Analysis for a Class of Competitive Non-transported Bicyclic Inhibitors of the Betaine/GABA Transporter BGT1. Frontiers in Chemistry. 9: 736457. PMID 34595152 DOI: 10.3389/fchem.2021.736457 |
0.383 |
|
| 2021 |
Falk-Petersen CB, Rostrup F, Löffler R, Buchleihtner S, Harpsøe K, Gloriam DE, Frølund B, Wellendorph P. δ. Molecular Pharmacology. PMID 33990405 DOI: 10.1124/molpharm.121.000266 |
0.363 |
|
| 2021 |
Rostrup F, Falk-Petersen CB, Harpso E K, Buchleithner S, Conforti I, Jung S, Gloriam DE, Schirmeister T, Wellendorph P, Fro Lund B. Structural Determinants for the Mode of Action of Imidazopyridine DS2 at δ-Containing γ-Aminobutyric Acid Type A Receptors. Journal of Medicinal Chemistry. PMID 33847501 DOI: 10.1021/acs.jmedchem.0c02163 |
0.357 |
|
| 2020 |
Kickinger S, Al-Khawaja A, Haugaard AS, Lie MEK, Bavo F, Löffler R, Damgaard M, Ecker GF, Frølund B, Wellendorph P. Exploring the molecular determinants for subtype-selectivity of 2-amino-1,4,5,6-tetrahydropyrimidine-5-carboxylic acid analogs as betaine/GABA transporter 1 (BGT1) substrate-inhibitors. Scientific Reports. 10: 12992. PMID 32747622 DOI: 10.1038/S41598-020-69908-W |
0.451 |
|
| 2020 |
Andersen JV, Jakobsen E, Westi EW, Lie MEK, Voss CM, Aldana BI, Schousboe A, Wellendorph P, Bak LK, Pinborg LH, Waagepetersen HS. Extensive astrocyte metabolism of γ-aminobutyric acid (GABA) sustains glutamine synthesis in the mammalian cerebral cortex. Glia. PMID 32584476 DOI: 10.1002/Glia.23872 |
0.393 |
|
| 2020 |
Falk-Petersen CB, Tsonkov TM, Nielsen MS, Harpsøe K, Bundgaard C, Frølund B, Kristiansen U, Gloriam DE, Wellendorph P. Discovery of a new class of orthosteric antagonists with nanomolar potency at extrasynaptic GABA receptors. Scientific Reports. 10: 10078. PMID 32572053 DOI: 10.1038/S41598-020-66821-0 |
0.514 |
|
| 2020 |
Dalby NO, Falk-Petersen CB, Leurs U, Scholze P, Krall J, Frølund B, Wellendorph P. Silencing of spontaneous activity at α4β1/3δ GABA receptors in hippocampal granule cells reveals different ligand pharmacology. British Journal of Pharmacology. PMID 32484592 DOI: 10.1111/Bph.15146 |
0.416 |
|
| 2020 |
Lie MEK, Kickinger S, Skovgaard-Petersen J, Ecker GF, Clausen RP, Schousboe A, White HS, Wellendorph P. Pharmacological Characterization of a Betaine/GABA Transporter 1 (BGT1) Inhibitor Displaying an Unusual Biphasic Inhibition Profile and Anti-seizure Effects. Neurochemical Research. PMID 32248400 DOI: 10.1007/S11064-020-03017-Y |
0.435 |
|
| 2020 |
Kickinger S, Al-Khawaja A, Haugaard AS, Lie ME, Bavo F, Löffler R, Damgaard M, Frølund B, Franz Ecker G, Wellendorph P. Unraveling the Molecular Determinants for GABA Transporter Subtype Selectivity Biophysical Journal. 118: 130a. DOI: 10.1016/J.Bpj.2019.11.842 |
0.393 |
|
| 2019 |
Thiesen L, Belew ZM, Griem-Krey N, Pedersen SF, Crocoll C, Nour-Eldin HH, Wellendorph P. The γ-hydroxybutyric acid (GHB) analogue NCS-382 is a substrate for both monocarboxylate transporters subtypes 1 and 4. European Journal of Pharmaceutical Sciences : Official Journal of the European Federation For Pharmaceutical Sciences. 143: 105203. PMID 31866563 DOI: 10.1016/J.Ejps.2019.105203 |
0.401 |
|
| 2019 |
L'Estrade ET, Hansen HD, Falk-Petersen C, Haugaard A, Griem-Krey N, Jung S, Lüddens H, Schirmeister T, Erlandsson M, Ohlsson T, Knudsen GM, Herth MM, Wellendorph P, Frølund B. Synthesis and Pharmacological Evaluation of [C]4-Methoxy--[2-(thiophen-2-yl)imidazo[1,2-]pyridin-3-yl]benzamide as a Brain Penetrant PET Ligand Selective for the δ-Subunit-Containing γ-Aminobutyric Acid Type A Receptors. Acs Omega. 4: 8846-8851. PMID 31459972 DOI: 10.1021/acsomega.9b00434 |
0.355 |
|
| 2019 |
Giraudo A, Krall J, Bavo F, Nielsen B, Kongstad KT, Rolando B, De Blasio R, Gloriam DE, Löffler R, Thiesen L, Harpsøe K, Frydenvang K, Boschi D, Wellendorph P, Lolli ML, et al. Five-Membered N-Heterocyclic Scaffolds as Novel Amino Bioisosteres at γ-Aminobutyric Acid (GABA) Type A Receptors and GABA Transporters. Journal of Medicinal Chemistry. 62: 5797-5809. PMID 31117514 DOI: 10.1021/Acs.Jmedchem.9B00026 |
0.503 |
|
| 2019 |
Kickinger S, Hellsberg E, BenteFrølund, Schousboe A, Ecker GF, Wellendorph P. Structural and molecular aspects of betaine-GABA transporter 1 (BGT1) and its relation to brain function. Neuropharmacology. PMID 31108110 DOI: 10.1016/J.Neuropharm.2019.05.021 |
0.425 |
|
| 2019 |
Griem-Krey N, Klein AB, Herth M, Wellendorph P. Autoradiography as a Simple and Powerful Method for Visualization and Characterization of Pharmacological Targets. Journal of Visualized Experiments : Jove. PMID 30933077 DOI: 10.3791/58879 |
0.367 |
|
| 2019 |
Krall J, Bavo F, Falk-Petersen CB, Jensen CH, Nielsen JO, Tian Y, Anglani V, Kongstad KT, Piilgaard L, Nielsen B, Gloriam DE, Kehler J, Jensen A, Harpsøe K, Wellendorph P, et al. Discovery of 2-(Imidazo[1,2-b]pyridazin-2-yl)acetic Acid as a New Class of Ligands Selective for the γ-Hydroxybutyric Acid (GHB) High-Affinity Binding Sites. Journal of Medicinal Chemistry. PMID 30763084 DOI: 10.1021/Acs.Jmedchem.9B00131 |
0.455 |
|
| 2019 |
Thiesen L, Frølund B, Wellendorph P. Lack of evidence for synaptic high-affinity γ-hydroxybutyric acid (GHB) transport in rat brain synaptosomes and 11 Na -dependent SLC neurotransmitter transporters. Journal of Neurochemistry. 149: 195-210. PMID 30570143 DOI: 10.1111/Jnc.14649 |
0.371 |
|
| 2017 |
Lie ME, Gowing EK, Clausen RP, Wellendorph P, Clarkson AN. Inhibition of GABA transporters fails to afford significant protection following focal cerebral ischemia. Journal of Cerebral Blood Flow and Metabolism : Official Journal of the International Society of Cerebral Blood Flow and Metabolism. 271678X17743669. PMID 29148909 DOI: 10.1177/0271678X17743669 |
0.346 |
|
| 2017 |
Al-Khawaja A, Haugaard AS, Marek A, Löffler R, Thiesen L, Santiveri M, Damgaard M, Bundgaard C, Frølund B, Wellendorph P. Pharmacological characterization of [3H]ATPCA as a substrate for studying the functional role of the betaine/GABA transporter 1 and the creatine transporter. Acs Chemical Neuroscience. PMID 29131576 DOI: 10.1021/Acschemneuro.7B00351 |
0.458 |
|
| 2017 |
Krall J, Jensen CH, Bavo F, Falk-Petersen CB, Haugaard AS, Vogensen SB, Tian Y, Nittegaard-Nielsen M, Sigurdardóttir SB, Kehler J, Kongstad KT, Gloriam DE, Clausen RP, Harpsøe K, Wellendorph P, et al. Molecular hybridization of potent and selective γ-Hydroxybutyric Acid (GHB) ligands; Design, synthesis, binding studies, and molecular modelling of novel 3-hydroxycyclopent-1-enecarboxylic Acid (HOCPCA) and trans-γ-hydroxycrotonic acid (T-HCA) Analogs. Journal of Medicinal Chemistry. PMID 29028338 DOI: 10.1021/Acs.Jmedchem.7B01351 |
0.413 |
|
| 2017 |
Jørgensen L, Al-Khawaja A, Kickinger S, Vogensen SB, Skovgaard-Petersen J, Jensen ER, Borkar N, Löffler R, Madsen KK, Bräuner-Osborne H, Schousboe A, Ecker GF, Wellendorph P, Clausen RP. Structure-activity relationship, pharmacological characterization and molecular modeling of non-competitive inhibitors of the betaine/γ-aminobutyric acid transporter 1 (BGT1). Journal of Medicinal Chemistry. PMID 28991462 DOI: 10.1021/Acs.Jmedchem.7B00924 |
0.409 |
|
| 2017 |
Schousboe A, Wellendorph P, Frølund B, Clausen RP, Krogsgaard-Larsen P. Astrocytic GABA Transporters: Pharmacological Properties and Targets for Antiepileptic Drugs. Advances in Neurobiology. 16: 283-296. PMID 28828616 DOI: 10.1007/978-3-319-55769-4_14 |
0.411 |
|
| 2017 |
Lie MEK, Al-Khawaja A, Damgaard M, Haugaard AS, Schousboe A, Clarkson AN, Wellendorph P. Glial GABA Transporters as Modulators of Inhibitory Signalling in Epilepsy and Stroke. Advances in Neurobiology. 16: 137-167. PMID 28828609 DOI: 10.1007/978-3-319-55769-4_7 |
0.414 |
|
| 2017 |
Frandsen IO, Boesgaard MW, Fidom K, Hauser AS, Isberg V, Bräuner-Osborne H, Wellendorph P, Gloriam DE. Identification of Histamine H Receptor Ligands Using a New Crystal Structure Fragment-based Method. Scientific Reports. 7: 4829. PMID 28684785 DOI: 10.1038/S41598-017-05058-W |
0.431 |
|
| 2017 |
Damgaard M, Al-Khawaja A, Nittegaard-Nielsen M, Petersen RF, Wellendorph P, Frølund B. Monastrol, a 3,4-dihydropyrimidin-2(1H)-thione, as structural scaffold for the development of modulators for GHB high-affinity binding sites and αβδ GABA receptors. European Journal of Medicinal Chemistry. 138: 300-312. PMID 28683403 DOI: 10.1016/J.Ejmech.2017.06.024 |
0.492 |
|
| 2017 |
Falk-Petersen CB, Søgaard R, Madsen KL, Klein AB, Frølund B, Wellendorph P. Development of a Robust Mammalian Cell-based Assay for Studying Recombinant α4 β1/3 δ GABAA Receptor Subtypes. Basic & Clinical Pharmacology & Toxicology. PMID 28299900 DOI: 10.1111/Bcpt.12778 |
0.411 |
|
| 2017 |
Jensen CH, Hansen HD, Bay T, Vogensen SB, Lehel S, Thiesen L, Bundgaard C, Clausen RP, Knudsen GM, Herth MM, Wellendorph P, Frølund B. Radiosynthesis and Evaluation of [(11)C]3-Hydroxycyclopent-1-enecarboxylic Acid as Potential PET Ligand for the High-Affinity γ-Hydroxybutyric Acid Binding Sites. Acs Chemical Neuroscience. 8: 22-27. PMID 28095676 DOI: 10.1021/Acschemneuro.6B00335 |
0.401 |
|
| 2016 |
Jørgensen S, Have CT, Underwood CR, Johansen LD, Wellendorph P, Gjesing AP, Jørgensen CV, Quan S, Rui G, Inoue A, Linneberg A, Grarup N, Jun W, Pedersen O, Hansen T, et al. Genetic Variations in the Human GPRC6A Receptor Control Cell Surface Expression and Function. The Journal of Biological Chemistry. PMID 27986810 DOI: 10.1074/Jbc.M116.756577 |
0.388 |
|
| 2016 |
Klein AB, Bay T, Villumsen IS, Falk-Petersen CB, Marek A, Frølund B, Clausen RP, Hansen HD, Knudsen GM, Wellendorph P. Autoradiographic imaging and quantification of the high-affinity GHB binding sites in rodent brain using (3)H-HOCPCA. Neurochemistry International. PMID 27615059 DOI: 10.1016/J.Neuint.2016.09.002 |
0.415 |
|
| 2016 |
Kuhne S, Nøhr AC, Marek A, Elbert T, Klein AB, Bräuner-Osborne H, Wellendorph P, Pedersen DS. Radiosynthesis and characterisation of a potent and selective GPR139 agonist radioligand Rsc Advances. 6: 947-952. DOI: 10.1039/C5Ra21326F |
0.429 |
|
| 2016 |
Klein AB, Nittegaard-Nielsen M, Christensen JT, Al-Khawaja A, Wellendorph P. Demonstration of the dynamic mass redistribution label-free technology as a useful cell-based pharmacological assay for endogenously expressed GABAA receptors Medchemcomm. 7: 426-432. DOI: 10.1039/C5Md00442J |
0.462 |
|
| 2015 |
Damgaard M, Al-Khawaja A, Vogensen SB, Jurik A, Sijm M, Lie ME, Bæk MI, Rosenthal E, Jensen AA, Ecker GF, Frølund B, Wellendorph P, Clausen RP. Identification of the First Highly Subtype-Selective Inhibitor of Human GABA Transporter GAT3. Acs Chemical Neuroscience. PMID 26154082 DOI: 10.1021/Acschemneuro.5B00150 |
0.436 |
|
| 2015 |
Thiesen L, Kehler J, Clausen RP, Frølund B, Bundgaard C, Wellendorph P. In Vitro and In Vivo Evidence for Active Brain Uptake of the GHB Analog HOCPCA by the Monocarboxylate Transporter Subtype 1. The Journal of Pharmacology and Experimental Therapeutics. 354: 166-74. PMID 25986445 DOI: 10.1124/Jpet.115.224543 |
0.419 |
|
| 2015 |
Villumsen IS, Wellendorph P, Smart TG. Pharmacological characterisation of murine α4β1δ GABAA receptors expressed in Xenopus oocytes. Bmc Neuroscience. 16: 8. PMID 25887256 DOI: 10.1186/S12868-015-0148-4 |
0.502 |
|
| 2014 |
Eghorn LF, Hoestgaard-Jensen K, Kongstad KT, Bay T, Higgins D, Frølund B, Wellendorph P. Positive allosteric modulation of the GHB high-affinity binding site by the GABAA receptor modulator monastrol and the flavonoid catechin. European Journal of Pharmacology. 740: 570-7. PMID 24973695 DOI: 10.1016/J.Ejphar.2014.06.028 |
0.521 |
|
| 2014 |
Al-Khawaja A, Petersen JG, Damgaard M, Jensen MH, Vogensen SB, Lie ME, Kragholm B, Bräuner-Osborne H, Clausen RP, Frølund B, Wellendorph P. Pharmacological identification of a guanidine-containing β-alanine analogue with low micromolar potency and selectivity for the betaine/GABA transporter 1 (BGT1). Neurochemical Research. 39: 1988-96. PMID 24852577 DOI: 10.1007/S11064-014-1336-9 |
0.463 |
|
| 2014 |
Bay T, Eghorn LF, Klein AB, Wellendorph P. GHB receptor targets in the CNS: focus on high-affinity binding sites. Biochemical Pharmacology. 87: 220-8. PMID 24269284 DOI: 10.1016/J.Bcp.2013.10.028 |
0.532 |
|
| 2014 |
Clemmensen C, Smajilovic S, Wellendorph P, Bräuner-Osborne H. The GPCR, class C, group 6, subtype A (GPRC6A) receptor: from cloning to physiological function. British Journal of Pharmacology. 171: 1129-41. PMID 24032653 DOI: 10.1111/Bph.12365 |
0.459 |
|
| 2014 |
Smajilovic S, Wellendorph P, Bräuner-Osborne H. Promiscuous seven transmembrane receptors sensing L-α-amino acids. Current Pharmaceutical Design. 20: 2693-702. PMID 23886393 DOI: 10.2174/13816128113199990576 |
0.438 |
|
| 2013 |
Vogensen SB, Marek A, Bay T, Wellendorph P, Kehler J, Bundgaard C, Frølund B, Pedersen MHF, Clausen RP. New synthesis and tritium labeling of a selective ligand for studying high-affinity γ-hydroxybutyrate (GHB) binding sites Journal of Medicinal Chemistry. 56: 8201-8205. PMID 24053696 DOI: 10.1021/Jm4011719 |
0.405 |
|
| 2013 |
Jacobsen SE, Nørskov-Lauritsen L, Thomsen AR, Smajilovic S, Wellendorph P, Larsson NH, Lehmann A, Bhatia VK, Bräuner-Osborne H. Delineation of the GPRC6A receptor signaling pathways using a mammalian cell line stably expressing the receptor. The Journal of Pharmacology and Experimental Therapeutics. 347: 298-309. PMID 24008333 DOI: 10.1124/Jpet.113.206276 |
0.445 |
|
| 2013 |
Vogensen SB, Jørgensen L, Madsen KK, Borkar N, Wellendorph P, Skovgaard-Petersen J, Schousboe A, White HS, Krogsgaard-Larsen P, Clausen RP. Selective mGAT2 (BGT-1) GABA uptake inhibitors: design, synthesis, and pharmacological characterization. Journal of Medicinal Chemistry. 56: 2160-4. PMID 23398473 DOI: 10.1021/Jm301872X |
0.43 |
|
| 2013 |
Karim N, Wellendorph P, Absalom N, Johnston GA, Hanrahan JR, Chebib M. Potency of GABA at human recombinant GABA(A) receptors expressed in Xenopus oocytes: a mini review. Amino Acids. 44: 1139-49. PMID 23385381 DOI: 10.1007/S00726-012-1456-Y |
0.461 |
|
| 2013 |
Jensen AA, Plath N, Pedersen MH, Isberg V, Krall J, Wellendorph P, Stensbøl TB, Gloriam DE, Krogsgaard-Larsen P, Frølund B. Design, synthesis, and pharmacological characterization of N- and O-substituted 5,6,7,8-tetrahydro-4H-isoxazolo[4,5-d]azepin-3-ol analogues: novel 5-HT(2A)/5-HT(2C) receptor agonists with pro-cognitive properties. Journal of Medicinal Chemistry. 56: 1211-27. PMID 23301527 DOI: 10.1021/Jm301656H |
0.338 |
|
| 2013 |
Smajilovic S, Clemmensen C, Johansen LD, Wellendorph P, Holst JJ, Thams PG, Ogo E, Bräuner-Osborne H. The L-α-amino acid receptor GPRC6A is expressed in the islets of Langerhans but is not involved in L-arginine-induced insulin release. Amino Acids. 44: 383-90. PMID 22714012 DOI: 10.1007/S00726-012-1341-8 |
0.355 |
|
| 2012 |
Absalom N, Eghorn LF, Villumsen IS, Karim N, Bay T, Olsen JV, Knudsen GM, Bräuner-Osborne H, Frølund B, Clausen RP, Chebib M, Wellendorph P. α4βδ GABA(A) receptors are high-affinity targets for γ-hydroxybutyric acid (GHB). Proceedings of the National Academy of Sciences of the United States of America. 109: 13404-9. PMID 22753476 DOI: 10.1073/Pnas.1204376109 |
0.546 |
|
| 2012 |
Karim N, Wellendorph P, Absalom N, Bang LH, Jensen ML, Hansen MM, Lee HJ, Johnston GA, Hanrahan JR, Chebib M. Low nanomolar GABA effects at extrasynaptic α4β1/β3δ GABA(A) receptor subtypes indicate a different binding mode for GABA at these receptors. Biochemical Pharmacology. 84: 549-57. PMID 22658986 DOI: 10.1016/J.Bcp.2012.05.017 |
0.482 |
|
| 2012 |
Pan Y, Gerasimov MR, Kvist T, Wellendorph P, Madsen KK, Pera E, Lee H, Schousboe A, Chebib M, Bräuner-Osborne H, Craft CM, Brodie JD, Schiffer WK, Dewey SL, Miller SR, et al. (1S, 3S)-3-amino-4-difluoromethylenyl-1-cyclopentanoic acid (CPP-115), a potent γ-aminobutyric acid aminotransferase inactivator for the treatment of cocaine addiction Journal of Medicinal Chemistry. 55: 357-366. PMID 22128851 DOI: 10.1021/Jm201231W |
0.325 |
|
| 2011 |
Gloriam DE, Wellendorph P, Johansen LD, Thomsen AR, Phonekeo K, Pedersen DS, Bräuner-Osborne H. Chemogenomic discovery of allosteric antagonists at the GPRC6A receptor. Chemistry & Biology. 18: 1489-98. PMID 22118683 DOI: 10.1016/J.Chembiol.2011.09.012 |
0.409 |
|
| 2011 |
Karim N, Gavande N, Wellendorph P, Johnston GA, Hanrahan JR, Chebib M. 3-Hydroxy-2'-methoxy-6-methylflavone: a potent anxiolytic with a unique selectivity profile at GABA(A) receptor subtypes. Biochemical Pharmacology. 82: 1971-83. PMID 21924247 DOI: 10.1016/J.Bcp.2011.09.002 |
0.48 |
|
| 2010 |
Wellendorph P, Johansen LD, Bräuner-Osborne H. The emerging role of promiscuous 7TM receptors as chemosensors for food intake. Vitamins and Hormones. 84: 151-84. PMID 21094899 DOI: 10.1016/B978-0-12-381517-0.00005-9 |
0.452 |
|
| 2010 |
Sabbatini P, Wellendorph P, Høg S, Pedersen MHF, Bräuner-Osborne H, Martiny L, Frølund B, Clausen RP. Design, synthesis, and in vitro pharmacology of new radiolabeled γ-hydroxybutyric acid analogues including photolabile analogues with irreversible binding to the high-affinity γ-hydroxybutyric acid binding sites Journal of Medicinal Chemistry. 53: 6506-6510. PMID 20715819 DOI: 10.1021/Jm1006325 |
0.416 |
|
| 2010 |
Wellendorph P, Høg S, Sabbatini P, Pedersen MHF, Martiny L, Knudsen GM, Frølund B, Clausen RP, Bräuner-Osborne H. Novel radioiodinated γ-hydroxybutyric acid analogues for radiolabeling and photolinking of high-affinity γ-hydroxybutyric acid binding sites Journal of Pharmacology and Experimental Therapeutics. 335: 458-464. PMID 20696866 DOI: 10.1124/Jpet.110.170670 |
0.416 |
|
| 2009 |
Wellendorph P, Høg S, Skonberg C, Bräuner-Osborne H. Phenylacetic acids and the structurally related non-steroidal anti-inflammatory drug diclofenac bind to specific gamma-hydroxybutyric acid sites in rat brain. Fundamental & Clinical Pharmacology. 23: 207-13. PMID 19645815 DOI: 10.1111/J.1472-8206.2008.00664.X |
0.497 |
|
| 2009 |
Wellendorph P, Johansen LD, Bräuner-Osborne H. Molecular pharmacology of promiscuous seven transmembrane receptors sensing organic nutrients. Molecular Pharmacology. 76: 453-65. PMID 19487246 DOI: 10.1124/Mol.109.055244 |
0.456 |
|
| 2009 |
Wellendorph P, Bräuner-Osborne H. Molecular basis for amino acid sensing by family C G-protein-coupled receptors. British Journal of Pharmacology. 156: 869-84. PMID 19298394 DOI: 10.1111/J.1476-5381.2008.00078.X |
0.502 |
|
| 2009 |
Wellendorph P, Johansen LD, Jensen AA, Casanova E, Gassmann M, Deprez P, Clément-Lacroix P, Bettler B, Bräuner-Osborne H. No evidence for a bone phenotype in GPRC6A knockout mice under normal physiological conditions. Journal of Molecular Endocrinology. 42: 215-23. PMID 19103720 DOI: 10.1677/Jme-08-0149 |
0.534 |
|
| 2008 |
Høg S, Wellendorph P, Nielsen B, Frydenvang K, Dahl IF, Bräuner-Osborne H, Brehm L, Frølund B, Clausen RP. Novel high-affinity and selective biaromatic 4-substituted γ-hydroxybutyric acid (GHB) analogues as GHB ligands: Design, synthesis, and binding studies Journal of Medicinal Chemistry. 51: 8088-8095. PMID 19053823 DOI: 10.1021/Jm801112U |
0.539 |
|
| 2008 |
Wellendorph P, Hansen KB, Christiansen B, Burhenne N, Balsgaard A, Greenwood JR, Walter B, Schmale H, Egebjerg J, Bräuner-Osborne H. Characterization of GPRC6A: a 7TM receptor activated by L-alpha-amino acids and positively modulated by divalent cations Fundamental & Clinical Pharmacology. 22: 25-25. DOI: 10.1111/J.1472-8206.2008.00591.X |
0.393 |
|
| 2007 |
Wellendorph P, Burhenne N, Christiansen B, Walter B, Schmale H, Bräuner-Osborne H. The rat GPRC6A: cloning and characterization. Gene. 396: 257-67. PMID 17478059 DOI: 10.1016/J.Gene.2007.03.008 |
0.414 |
|
| 2007 |
Bräuner-Osborne H, Wellendorph P, Jensen AA. Structure, pharmacology and therapeutic prospects of family C G-protein coupled receptors. Current Drug Targets. 8: 169-84. PMID 17266540 DOI: 10.2174/138945007779315614 |
0.494 |
|
| 2007 |
Christiansen B, Hansen KB, Wellendorph P, Bräuner-Osborne H. Pharmacological characterization of mouse GPRC6A, an L-alpha-amino-acid receptor modulated by divalent cations. British Journal of Pharmacology. 150: 798-807. PMID 17245368 DOI: 10.1038/Sj.Bjp.0707121 |
0.454 |
|
| 2006 |
Olsen CA, Mellor IR, Wellendorph P, Usherwood PN, Witt M, Franzyk H, Jaroszewski JW. Tuning wasp toxin structure for nicotinic receptor antagonism: cyclohexylalanine-containing analogues as potent and voltage-dependent blockers. Chemmedchem. 1: 303-5. PMID 16892364 DOI: 10.1002/Cmdc.200500067 |
0.355 |
|
| 2006 |
Lolli ML, Hansen SL, Rolando B, Nielsen B, Wellendorph P, Madsen K, Larsen OM, Kristiansen U, Fruttero R, Gasco A, Johansen TN. Hydroxy-1,2,5-oxadiazolyl moiety as bioisoster of the carboxy function. Synthesis, ionization constants, and pharmacological characterization of γ-aminobutyric acid (GABA) related compounds Journal of Medicinal Chemistry. 49: 4442-4446. PMID 16821803 DOI: 10.1021/Jm051288B |
0.477 |
|
| 2006 |
Christiansen B, Wellendorph P, Bräuner-Osborne H. Activity of L-alpha-amino acids at the promiscuous goldfish odorant receptor 5.24. European Journal of Pharmacology. 536: 98-101. PMID 16546162 DOI: 10.1016/J.Ejphar.2006.02.015 |
0.424 |
|
| 2006 |
Christiansen B, Wellendorph P, Bräuner-Osborne H. Known regulators of nitric oxide synthase and arginase are agonists at the human G-protein-coupled receptor GPRC6A. British Journal of Pharmacology. 147: 855-63. PMID 16491104 DOI: 10.1038/Sj.Bjp.0706682 |
0.457 |
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| 2006 |
Olsen C, Mellor I, Wellendorph P, Usherwood P, Witt M, Franzyk H, Jaroszewski J. Cover Picture: Tuning Wasp Toxin Structure for Nicotinic Receptor Antagonism: Cyclohexylalanine-Containing Analogues as Potent and Voltage-Dependent Blockers (ChemMedChem 3/2006) Chemmedchem. 1: 281-281. DOI: 10.1002/Cmdc.200690006 |
0.354 |
|
| 2005 |
Wellendorph P, Høg S, Greenwood JR, de Lichtenberg A, Nielsen B, Frølund B, Brehm L, Clausen RP, Bräuner-Osborne H. Novel cyclic gamma-hydroxybutyrate (GHB) analogs with high affinity and stereoselectivity of binding to GHB sites in rat brain. The Journal of Pharmacology and Experimental Therapeutics. 315: 346-51. PMID 16014570 DOI: 10.1124/Jpet.105.090472 |
0.529 |
|
| 2005 |
Wellendorph P, Hansen KB, Balsgaard A, Greenwood JR, Egebjerg J, Bräuner-Osborne H. Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids. Molecular Pharmacology. 67: 589-97. PMID 15576628 DOI: 10.1124/Mol.104.007559 |
0.474 |
|
| 2004 |
Wellendorph P, Bräuner-Osborne H. Molecular cloning, expression, and sequence analysis of GPRC6A, a novel family C G-protein-coupled receptor. Gene. 335: 37-46. PMID 15194188 DOI: 10.1016/J.Gene.2004.03.003 |
0.392 |
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| 2003 |
Kaupmann K, Cryan JF, Wellendorph P, Mombereau C, Sansig G, Klebs K, Schmutz M, Froestl W, van der Putten H, Mosbacher J, Bräuner-Osborne H, Waldmeier P, Bettler B. Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice. The European Journal of Neuroscience. 18: 2722-30. PMID 14656321 DOI: 10.1111/J.1460-9568.2003.03013.X |
0.639 |
|
| 2002 |
Wellendorph P, Goodman MW, Burstein ES, Nash NR, Brann MR, Weiner DM. Molecular cloning and pharmacology of functionally distinct isoforms of the human histamine H3 receptor Neuropharmacology. 42: 929-940. PMID 12069903 DOI: 10.1016/S0028-3908(02)00041-2 |
0.463 |
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