Klemens Kaupmann - Publications

Novartis pharma, Basel, Basel, Basel-Stadt, Switzerland 
GABAB receptors

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Year Citation  Score
2020 Velcicky J, Wilcken R, Cotesta S, Janser P, Schlapbach A, Wagner T, Piechon P, Villard F, Bouhelal R, Piller F, Harlfinger S, Stringer R, Fehlmann D, Kaupmann K, Littlewood-Evans A, et al. Discovery and Optimization of Novel SUCNR1 Inhibitors: Design of Zwitterionic Derivatives with a Salt Bridge for the Improvement of Oral Exposure. Journal of Medicinal Chemistry. PMID 32856916 DOI: 10.1021/acs.jmedchem.0c01020  0.68
2019 Haffke M, Fehlmann D, Rummel G, Boivineau J, Duckely M, Gommermann N, Cotesta S, Sirockin F, Freuler F, Littlewood-Evans A, Kaupmann K, Jaakola VP. Structural basis of species-selective antagonist binding to the succinate receptor. Nature. 574: 581-585. PMID 31645725 DOI: 10.1038/s41586-019-1663-8  0.68
2017 Jacobson LH, Hoyer D, Fehlmann D, Bettler B, Kaupmann K, Cryan JF. Blunted 5-HT1A receptor-mediated responses and antidepressant-like behavior in mice lacking the GABAB1a but not GABAB1b subunit isoforms. Psychopharmacology. PMID 28070618 DOI: 10.1007/s00213-016-4521-5  1
2015 Jacobson LH, Sweeney FF, Kaupmann K, O'Leary OF, Gassmann M, Bettler B, Cryan JF. Differential Roles of GABAB1 Subunit Isoforms on Locomotor Responses to Acute and Repeated Administration of Cocaine. Behavioural Brain Research. PMID 26518330 DOI: 10.1016/j.bbr.2015.10.039  0.96
2015 Krumova P, Reyniers L, Meyer M, Lobbestael E, Stauffer D, Gerrits B, Muller L, Hoving S, Kaupmann K, Voshol J, Fabbro D, Bauer A, Rovelli G, Taymans JM, Bouwmeester T, et al. Chemical genetic approach identifies microtubule affinity-regulating kinase 1 as a leucine-rich repeat kinase 2 substrate. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 29: 2980-92. PMID 25854701 DOI: 10.1096/fj.14-262329  0.96
2014 Gee CE, Peterlik D, Neuhäuser C, Bouhelal R, Kaupmann K, Laue G, Uschold-Schmidt N, Feuerbach D, Zimmermann K, Ofner S, Cryan JF, van der Putten H, Fendt M, Vranesic I, Glatthar R, et al. Blocking metabotropic glutamate receptor subtype 7 (mGlu7) via the Venus flytrap domain (VFTD) inhibits amygdala plasticity, stress, and anxiety-related behavior. The Journal of Biological Chemistry. 289: 10975-87. PMID 24596089 DOI: 10.1074/jbc.M113.542654  0.96
2012 Baldo B, Weiss A, Parker CN, Bibel M, Paganetti P, Kaupmann K. A screen for enhancers of clearance identifies huntingtin as a heat shock protein 90 (Hsp90) client protein. The Journal of Biological Chemistry. 287: 1406-14. PMID 22123826 DOI: 10.1074/jbc.M111.294801  0.96
2011 Herzig MC, Kolly C, Persohn E, Theil D, Schweizer T, Hafner T, Stemmelen C, Troxler TJ, Schmid P, Danner S, Schnell CR, Mueller M, Kinzel B, Grevot A, Bolognani F, ... ... Kaupmann K, et al. LRRK2 protein levels are determined by kinase function and are crucial for kidney and lung homeostasis in mice. Human Molecular Genetics. 20: 4209-23. PMID 21828077 DOI: 10.1093/hmg/ddr348  0.96
2011 Hintermann S, Hurth K, Nozulak J, Tintelnot-Blomley M, Aichholz R, Blanz J, Kaupmann K, Mosbacher J. Exploring subtype selectivity and metabolic stability of a novel series of ligands for the benzodiazepine binding site of the GABAA receptor. Bioorganic & Medicinal Chemistry Letters. 21: 1523-6. PMID 21277199 DOI: 10.1016/j.bmcl.2010.12.107  0.96
2011 Vlachou S, Paterson NE, Guery S, Kaupmann K, Froestl W, Banerjee D, Finn MG, Markou A. Both GABA(B) receptor activation and blockade exacerbated anhedonic aspects of nicotine withdrawal in rats. European Journal of Pharmacology. 655: 52-8. PMID 21262222 DOI: 10.1016/j.ejphar.2011.01.009  0.96
2009 Maccioni P, Carai MA, Kaupmann K, Guery S, Froestl W, Leite-Morris KA, Gessa GL, Colombo G. Reduction of alcohol's reinforcing and motivational properties by the positive allosteric modulator of the GABA(B) receptor, BHF177, in alcohol-preferring rats. Alcoholism, Clinical and Experimental Research. 33: 1749-56. PMID 19572981 DOI: 10.1111/j.1530-0277.2009.01012.x  0.96
2008 Tiao JY, Bradaia A, Biermann B, Kaupmann K, Metz M, Haller C, Rolink AG, Pless E, Barlow PN, Gassmann M, Bettler B. The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function. The Journal of Biological Chemistry. 283: 31005-11. PMID 18765663 DOI: 10.1074/jbc.M804464200  0.96
2008 Waldmeier PC, Kaupmann K, Urwyler S. Roles of GABAB receptor subtypes in presynaptic auto- and heteroreceptor function regulating GABA and glutamate release. Journal of Neural Transmission (Vienna, Austria : 1996). 115: 1401-11. PMID 18665320 DOI: 10.1007/s00702-008-0095-7  0.96
2008 Paterson NE, Vlachou S, Guery S, Kaupmann K, Froestl W, Markou A. Positive modulation of GABA(B) receptors decreased nicotine self-administration and counteracted nicotine-induced enhancement of brain reward function in rats. The Journal of Pharmacology and Experimental Therapeutics. 326: 306-14. PMID 18445779 DOI: 10.1124/jpet.108.139204  0.96
2007 Guery S, Floersheim P, Kaupmann K, Froestl W. Syntheses and optimization of new GS39783 analogues as positive allosteric modulators of GABA B receptors. Bioorganic & Medicinal Chemistry Letters. 17: 6206-11. PMID 17884493 DOI: 10.1016/j.bmcl.2007.09.023  0.96
2007 Liechti ME, Lhuillier L, Kaupmann K, Markou A. Metabotropic glutamate 2/3 receptors in the ventral tegmental area and the nucleus accumbens shell are involved in behaviors relating to nicotine dependence. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 9077-85. PMID 17715344 DOI: 10.1523/JNEUROSCI.1766-07.2007  0.96
2007 Jacobson LH, Kelly PH, Bettler B, Kaupmann K, Cryan JF. Specific roles of GABA(B(1)) receptor isoforms in cognition. Behavioural Brain Research. 181: 158-62. PMID 17498817 DOI: 10.1016/j.bbr.2007.03.033  0.96
2007 Mombereau C, Lhuillier L, Kaupmann K, Cryan JF. GABAB receptor-positive modulation-induced blockade of the rewarding properties of nicotine is associated with a reduction in nucleus accumbens DeltaFosB accumulation. The Journal of Pharmacology and Experimental Therapeutics. 321: 172-7. PMID 17215447 DOI: 10.1124/jpet.106.116228  0.96
2007 Jacobson LH, Bettler B, Kaupmann K, Cryan JF. Behavioral evaluation of mice deficient in GABA(B(1)) receptor isoforms in tests of unconditioned anxiety. Psychopharmacology. 190: 541-53. PMID 17171558 DOI: 10.1007/s00213-006-0631-9  0.96
2007 Lhuillier L, Mombereau C, Cryan JF, Kaupmann K. GABA(B) receptor-positive modulation decreases selective molecular and behavioral effects of cocaine. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 32: 388-98. PMID 16710312 DOI: 10.1038/sj.npp.1301102  0.96
2006 Jacobson LH, Bettler B, Kaupmann K, Cryan JF. GABAB1 receptor subunit isoforms exert a differential influence on baseline but not GABAB receptor agonist-induced changes in mice. The Journal of Pharmacology and Experimental Therapeutics. 319: 1317-26. PMID 16990508 DOI: 10.1124/jpet.106.111971  0.96
2006 Dupuis DS, Relkovic D, Lhuillier L, Mosbacher J, Kaupmann K. Point mutations in the transmembrane region of GABAB2 facilitate activation by the positive modulator N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) in the absence of the GABAB1 subunit. Molecular Pharmacology. 70: 2027-36. PMID 16966477 DOI: 10.1124/mol.106.028183  0.96
2006 Jacobson LH, Kelly PH, Bettler B, Kaupmann K, Cryan JF. GABA(B(1)) receptor isoforms differentially mediate the acquisition and extinction of aversive taste memories. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 26: 8800-3. PMID 16928868 DOI: 10.1523/JNEUROSCI.2076-06.2006  0.96
2006 Shaban H, Humeau Y, Herry C, Cassasus G, Shigemoto R, Ciocchi S, Barbieri S, van der Putten H, Kaupmann K, Bettler B, Lüthi A. Generalization of amygdala LTP and conditioned fear in the absence of presynaptic inhibition. Nature Neuroscience. 9: 1028-35. PMID 16819521 DOI: 10.1038/nn1732  0.96
2006 Vigot R, Barbieri S, Bräuner-Osborne H, Turecek R, Shigemoto R, Zhang YP, Luján R, Jacobson LH, Biermann B, Fritschy JM, Vacher CM, Müller M, Sansig G, Guetg N, Cryan JF, ... Kaupmann K, et al. Differential compartmentalization and distinct functions of GABAB receptor variants. Neuron. 50: 589-601. PMID 16701209 DOI: 10.1016/j.neuron.2006.04.014  0.96
2006 Vacher CM, Gassmann M, Desrayaud S, Challet E, Bradaia A, Hoyer D, Waldmeier P, Kaupmann K, Pévet P, Bettler B. Hyperdopaminergia and altered locomotor activity in GABAB1-deficient mice. Journal of Neurochemistry. 97: 979-91. PMID 16606363 DOI: 10.1111/j.1471-4159.2006.03806.x  0.96
2005 Sauter K, Grampp T, Fritschy JM, Kaupmann K, Bettler B, Mohler H, Benke D. Subtype-selective interaction with the transcription factor CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP) regulates cell surface expression of GABA(B) receptors. The Journal of Biological Chemistry. 280: 33566-72. PMID 16081421 DOI: 10.1074/jbc.M503482200  0.96
2005 Gassmann M, Haller C, Stoll Y, Abdel Aziz S, Biermann B, Mosbacher J, Kaupmann K, Bettler B. The RXR-type endoplasmic reticulum-retention/retrieval signal of GABAB1 requires distant spacing from the membrane to function. Molecular Pharmacology. 68: 137-44. PMID 15805225 DOI: 10.1124/mol.104.010256  0.96
2005 Mombereau C, Kaupmann K, Gassmann M, Bettler B, van der Putten H, Cryan JF. Altered anxiety and depression-related behaviour in mice lacking GABAB(2) receptor subunits. Neuroreport. 16: 307-10. PMID 15706241 DOI: 10.1097/00001756-200502280-00021  0.96
2005 Cryan JF, Kaupmann K. Don't worry 'B' happy!: a role for GABA(B) receptors in anxiety and depression. Trends in Pharmacological Sciences. 26: 36-43. PMID 15629203 DOI: 10.1016/j.tips.2004.11.004  0.96
2005 Deriu D, Gassmann M, Firbank S, Ristig D, Lampert C, Mosbacher J, Froestl W, Kaupmann K, Bettler B, Grütter MG. Determination of the minimal functional ligand-binding domain of the GABAB1b receptor. The Biochemical Journal. 386: 423-31. PMID 15482257 DOI: 10.1042/BJ20040804  0.96
2004 Rüttimann E, Vacher CM, Gassmann M, Kaupmann K, Van der Putten H, Bettler B. Altered hippocampal expression of calbindin-D-28k and calretinin in GABA(B(1))-deficient mice. Biochemical Pharmacology. 68: 1613-20. PMID 15451404 DOI: 10.1016/j.bcp.2004.07.019  0.96
2004 Mombereau C, Kaupmann K, van der Putten H, Cryan JF. Altered response to benzodiazepine anxiolytics in mice lacking GABA B(1) receptors. European Journal of Pharmacology. 497: 119-20. PMID 15321743 DOI: 10.1016/j.ejphar.2004.06.036  0.96
2004 Fritschy JM, Sidler C, Parpan F, Gassmann M, Kaupmann K, Bettler B, Benke D. Independent maturation of the GABA(B) receptor subunits GABA(B1) and GABA(B2) during postnatal development in rodent brain. The Journal of Comparative Neurology. 477: 235-52. PMID 15305362 DOI: 10.1002/cne.20188  0.96
2004 Bettler B, Kaupmann K, Mosbacher J, Gassmann M. Molecular structure and physiological functions of GABA(B) receptors. Physiological Reviews. 84: 835-67. PMID 15269338 DOI: 10.1152/physrev.00036.2003  0.96
2004 Gassmann M, Shaban H, Vigot R, Sansig G, Haller C, Barbieri S, Humeau Y, Schuler V, Müller M, Kinzel B, Klebs K, Schmutz M, Froestl W, Heid J, Kelly PH, ... ... Kaupmann K, et al. Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 24: 6086-97. PMID 15240800 DOI: 10.1523/JNEUROSCI.5635-03.2004  0.96
2004 Cryan JF, Kelly PH, Chaperon F, Gentsch C, Mombereau C, Lingenhoehl K, Froestl W, Bettler B, Kaupmann K, Spooren WP. Behavioral characterization of the novel GABAB receptor-positive modulator GS39783 (N,N'-dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine): anxiolytic-like activity without side effects associated with baclofen or benzodiazepines. The Journal of Pharmacology and Experimental Therapeutics. 310: 952-63. PMID 15113848 DOI: 10.1124/jpet.104.066753  0.96
2004 Mombereau C, Kaupmann K, Froestl W, Sansig G, van der Putten H, Cryan JF. Genetic and pharmacological evidence of a role for GABA(B) receptors in the modulation of anxiety- and antidepressant-like behavior. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology. 29: 1050-62. PMID 15039762 DOI: 10.1038/sj.npp.1300413  0.96
2004 Urwyler S, Gjoni T, Kaupmann K, Pozza MF, Mosbacher J. Selected amino acids, dipeptides and arylalkylamine derivatives do not act as allosteric modulators at GABAB receptors. European Journal of Pharmacology. 483: 147-53. PMID 14729102 DOI: 10.1016/j.ejphar.2003.10.024  0.96
2003 Kaupmann K, Cryan JF, Wellendorph P, Mombereau C, Sansig G, Klebs K, Schmutz M, Froestl W, van der Putten H, Mosbacher J, Bräuner-Osborne H, Waldmeier P, Bettler B. Specific gamma-hydroxybutyrate-binding sites but loss of pharmacological effects of gamma-hydroxybutyrate in GABA(B)(1)-deficient mice. The European Journal of Neuroscience. 18: 2722-30. PMID 14656321 DOI: 10.1111/j.1460-9568.2003.03013.x  0.96
2003 Saghatelyan AK, Snapyan M, Gorissen S, Meigel I, Mosbacher J, Kaupmann K, Bettler B, Kornilov AV, Nifantiev NE, Sakanyan V, Schachner M, Dityatev A. Recognition molecule associated carbohydrate inhibits postsynaptic GABA(B) receptors: a mechanism for homeostatic regulation of GABA release in perisomatic synapses. Molecular and Cellular Neurosciences. 24: 271-82. PMID 14572452 DOI: 10.1016/S1044-7431(03)00163-5  0.96
2003 Urwyler S, Pozza MF, Lingenhoehl K, Mosbacher J, Lampert C, Froestl W, Koller M, Kaupmann K. N,N'-Dicyclopentyl-2-methylsulfanyl-5-nitro-pyrimidine-4,6-diamine (GS39783) and structurally related compounds: novel allosteric enhancers of gamma-aminobutyric acidB receptor function. The Journal of Pharmacology and Experimental Therapeutics. 307: 322-30. PMID 12954816 DOI: 10.1124/jpet.103.053074  0.96
2003 Oertle T, van der Haar ME, Bandtlow CE, Robeva A, Burfeind P, Buss A, Huber AB, Simonen M, Schnell L, Brösamle C, Kaupmann K, Vallon R, Schwab ME. Nogo-A inhibits neurite outgrowth and cell spreading with three discrete regions. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 23: 5393-406. PMID 12843238  0.96
2003 Pignot V, Hein AE, Barske C, Wiessner C, Walmsley AR, Kaupmann K, Mayeur H, Sommer B, Mir AK, Frentzel S. Characterization of two novel proteins, NgRH1 and NgRH2, structurally and biochemically homologous to the Nogo-66 receptor. Journal of Neurochemistry. 85: 717-28. PMID 12694398  0.96
2003 Froestl W, Bettler B, Bittiger H, Heid J, Kaupmann K, Mickel SJ, Strub D. Ligands for expression cloning and isolation of GABA(B) receptors. Farmaco (Società Chimica Italiana : 1989). 58: 173-83. PMID 12620413 DOI: 10.1016/S0014-827X(03)00018-1  0.96
2001 Urwyler S, Mosbacher J, Lingenhoehl K, Heid J, Hofstetter K, Froestl W, Bettler B, Kaupmann K. Positive allosteric modulation of native and recombinant gamma-aminobutyric acid(B) receptors by 2,6-Di-tert-butyl-4-(3-hydroxy-2,2-dimethyl-propyl)-phenol (CGP7930) and its aldehyde analog CGP13501. Molecular Pharmacology. 60: 963-71. PMID 11641424  0.96
2001 Schuler V, Lüscher C, Blanchet C, Klix N, Sansig G, Klebs K, Schmutz M, Heid J, Gentry C, Urban L, Fox A, Spooren W, Jaton AL, Vigouret J, Pozza M, ... ... Kaupmann K, et al. Epilepsy, hyperalgesia, impaired memory, and loss of pre- and postsynaptic GABA(B) responses in mice lacking GABA(B(1)). Neuron. 31: 47-58. PMID 11498050 DOI: 10.1016/S0896-6273(01)00345-2  0.96
2001 Froestl W, Bettler B, Bittiger H, Heid J, Kaupmann K, Mickel SJ, Strub D. Ligands for expression cloning and isolation of GABA(B) receptors. Farmaco (Società Chimica Italiana : 1989). 56: 101-5. PMID 11347948 DOI: 10.1016/S0014-827X(01)01003-5  0.96
2001 Pagano A, Rovelli G, Mosbacher J, Lohmann T, Duthey B, Stauffer D, Ristig D, Schuler V, Meigel I, Lampert C, Stein T, Prezeau L, Blahos J, Pin J, Froestl W, ... ... Kaupmann K, et al. C-terminal interaction is essential for surface trafficking but not for heteromeric assembly of GABA(b) receptors. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 21: 1189-202. PMID 11160389  0.96
2000 Galvez T, Urwyler S, Prézeau L, Mosbacher J, Joly C, Malitschek B, Heid J, Brabet I, Froestl W, Bettler B, Kaupmann K, Pin JP. Ca(2+) requirement for high-affinity gamma-aminobutyric acid (GABA) binding at GABA(B) receptors: involvement of serine 269 of the GABA(B)R1 subunit. Molecular Pharmacology. 57: 419-26. PMID 10692480  0.96
1999 Lingenhoehl K, Brom R, Heid J, Beck P, Froestl W, Kaupmann K, Bettler B, Mosbacher J. Gamma-hydroxybutyrate is a weak agonist at recombinant GABA(B) receptors. Neuropharmacology. 38: 1667-73. PMID 10587082 DOI: 10.1016/S0028-3908(99)00131-8  0.96
1999 Franek M, Pagano A, Kaupmann K, Bettler B, Pin JP, Blahos J. The heteromeric GABA-B receptor recognizes G-protein alpha subunit C-termini. Neuropharmacology. 38: 1657-66. PMID 10587081 DOI: 10.1016/S0028-3908(99)00135-5  0.96
1999 Froestl W, Bettler B, Bittiger H, Heid J, Kaupmann K, Mickel SJ, Strub D. Ligands for the isolation of GABA(B) receptors [corrected] . Neuropharmacology. 38: 1641-6. PMID 10587079 DOI: 10.1016/S0028-3908(99)00134-3  0.96
1999 Marshall FH, Jones KA, Kaupmann K, Bettler B. GABAB receptors - the first 7TM heterodimers. Trends in Pharmacological Sciences. 20: 396-9. PMID 10498952  1
1999 Pfaff T, Malitschek B, Kaupmann K, Prézeau L, Pin JP, Bettler B, Karschin A. Alternative splicing generates a novel isoform of the rat metabotropic GABA(B)R1 receptor. The European Journal of Neuroscience. 11: 2874-82. PMID 10457184 DOI: 10.1046/j.1460-9568.1999.00704.x  0.96
1999 Bischoff S, Leonhard S, Reymann N, Schuler V, Shigemoto R, Kaupmann K, Bettler B. Spatial distribution of GABA(B)R1 receptor mRNA and binding sites in the rat brain. The Journal of Comparative Neurology. 412: 1-16. PMID 10440706 DOI: 10.1002/(SICI)1096-9861(19990913)412:1<1::AID-CNE1>3.0.CO;2-D  0.96
1999 Malitschek B, Schweizer C, Keir M, Heid J, Froestl W, Mosbacher J, Kuhn R, Henley J, Joly C, Pin JP, Kaupmann K, Bettler B. The N-terminal domain of gamma-aminobutyric Acid(B) receptors is sufficient to specify agonist and antagonist binding. Molecular Pharmacology. 56: 448-54. PMID 10419566  0.96
1999 Mosbacher J, Kaupmann K, Schuler V, Ristig D, Struckmeyer K, Pfaff T, Karschin A, Pozza MF, Bettler B. Processing of GABABR1 in heterologous expression systems. Annals of the New York Academy of Sciences. 868: 689-92. PMID 10414355 DOI: 10.1111/j.1749-6632.1999.tb11347.x  0.96
1999 Sander T, Peters C, Kämmer G, Samochowiec J, Zirra M, Mischke D, Ziegler A, Kaupmann K, Bettler B, Epplen JT, Riess O. Association analysis of exonic variants of the gene encoding the GABAB receptor and idiopathic generalized epilepsy. American Journal of Medical Genetics. 88: 305-10. PMID 10402495 DOI: 10.1002/(SICI)1096-8628(19990820)88:4<305::AID-AJMG5>3.0.CO;2-X  0.96
1999 Galvez T, Parmentier ML, Joly C, Malitschek B, Kaupmann K, Kuhn R, Bittiger H, Froestl W, Bettler B, Pin JP. Mutagenesis and modeling of the GABAB receptor extracellular domain support a venus flytrap mechanism for ligand binding. The Journal of Biological Chemistry. 274: 13362-9. PMID 10224098 DOI: 10.1074/jbc.274.19.13362  0.96
1999 Marshall FH, Jones KA, Kaupmann K, Bettler B. GABA(B) receptors - The first 7TM heterodimers Trends in Pharmacological Sciences. 20: 396-399. DOI: 10.1016/S0165-6147(99)01383-8  0.96
1998 Kaupmann K, Bettler B. Heteromerization of GABAB Receptors: A New Principle for G Protein-Coupled Receptors. Satellite Symposium to the 28th Annual Meeting of the Society for Neuroscience Los Angeles, CA, November 5-7, 1998. Cns Drug Reviews. 4: 376-379. PMID 29200228 DOI: 10.1111/j.1527-3458.1998.tb00077.x  1
1998 Peters HC, Kämmer G, Volz A, Kaupmann K, Ziegler A, Bettler B, Epplen JT, Sander T, Riess O. Mapping, genomic structure, and polymorphisms of the human GABABR1 receptor gene: evaluation of its involvement in idiopathic generalized epilepsy. Neurogenetics. 2: 47-54. PMID 9933300 DOI: 10.1007/s100480050051  0.96
1998 Kaupmann K, Malitschek B, Schuler V, Heid J, Froestl W, Beck P, Mosbacher J, Bischoff S, Kulik A, Shigemoto R, Karschin A, Bettler B. GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature. 396: 683-7. PMID 9872317 DOI: 10.1038/25360  0.96
1998 Kaupmann K, Schuler V, Mosbacher J, Bischoff S, Bittiger H, Heid J, Froestl W, Leonhard S, Pfaff T, Karschin A, Bettler B. Human gamma-aminobutyric acid type B receptors are differentially expressed and regulate inwardly rectifying K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 95: 14991-6. PMID 9844003 DOI: 10.1073/pnas.95.25.14991  0.96
1998 Malitschek B, Rüegg D, Heid J, Kaupmann K, Bittiger H, Fröstl W, Bettler B, Kuhn R. Developmental changes of agonist affinity at GABABR1 receptor variants in rat brain. Molecular and Cellular Neurosciences. 12: 56-64. PMID 9770340 DOI: 10.1006/mcne.1998.0698  0.96
1998 Bettler B, Kaupmann K, Bowery N. GABAB receptors: drugs meet clones. Current Opinion in Neurobiology. 8: 345-50. PMID 9687348 DOI: 10.1016/S0959-4388(98)80059-7  0.96
1998 Kaupmann K, Bettler B. Heteromerization of GABA(B) receptors: A new principle for G protein- coupled receptors. Satellite symposium to the 28(th) annual meeting of the society for neuroscience Los Angeles, CA, November 5-7, 1998 Cns Drug Reviews. 4: 376-379.  0.96
1997 Kaupmann K, Huggel K, Heid J, Flor PJ, Bischoff S, Mickel SJ, McMaster G, Angst C, Bittiger H, Froestl W, Bettler B. Expression cloning of GABA(B) receptors uncovers similarity to metabotropic glutamate receptors. Nature. 386: 239-46. PMID 9069281 DOI: 10.1038/386239a0  0.96
1995 Kaupmann K, Bruns C, Raulf F, Weber HP, Mattes H, Lübbert H. Two amino acids, located in transmembrane domains VI and VII, determine the selectivity of the peptide agonist SMS 201-995 for the SSTR2 somatostatin receptor. The Embo Journal. 14: 727-35. PMID 7882976  0.96
1995 Hoyer D, Pérez J, Schoeffter P, Langenegger D, Schüpbach E, Kaupmann K, Lübbert H, Bruns C, Reubi JC. Pharmacological identity between somatostatin SS-2 binding sites and SSTR-1 receptors. European Journal of Pharmacology. 289: 151-61. PMID 7781706 DOI: 10.1016/0922-4106(95)90179-5  0.96
1994 Lengeling A, Zimmer WE, Goodman SR, Ma Y, Bloom ML, Bruneau G, Krieger M, Thibault J, Kaupmann K, Jockusch H. Exclusion of two candidate genes, Spnb-2 and Dcd, for the wobbler spinal muscular atrophy gene on proximal mouse chromosome 11. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 5: 163-6. PMID 8199405 DOI: 10.1007/BF00352348  0.96
1994 Pérez J, Rigo M, Kaupmann K, Bruns C, Yasuda K, Bell GI, Lübbert H, Hoyer D. Localization of somatostatin (SRIF) SSTR-1, SSTR-2 and SSTR-3 receptor mRNA in rat brain by in situ hybridization. Naunyn-Schmiedeberg's Archives of Pharmacology. 349: 145-60. PMID 8170498 DOI: 10.1007/BF00169831  0.96
1994 Jockusch H, Kaupmann K, Gronemeier M, Schleef M, Klocke R. Exploring the mammalian neuromuscular system by analysis of mutations: spinal muscular atrophy and myotonia. Progress in Neurobiology. 42: 313-7. PMID 8008830 DOI: 10.1016/0301-0082(94)90071-X  0.96
1994 Bruns C, Weckbecker G, Raulf F, Kaupmann K, Schoeffter P, Hoyer D, Lübbert H. Molecular pharmacology of somatostatin-receptor subtypes. Annals of the New York Academy of Sciences. 733: 138-46. PMID 7978861 DOI: 10.1111/j.1749-6632.1994.tb17263.x  0.96
1993 Schleef M, Werner K, Satzger U, Kaupmann K, Jockusch H. Chromosomal localization and genomic cloning of the mouse alpha-tropomyosin gene Tpm-1. Genomics. 17: 519-21. PMID 8406508 DOI: 10.1006/geno.1993.1361  0.96
1993 Kaupmann K, Bruns C, Hoyer D, Seuwen K, Lübbert H. Distribution and second messenger coupling of four somatostatin receptor subtypes expressed in brain. Febs Letters. 331: 53-9. PMID 8405411 DOI: 10.1016/0014-5793(93)80296-7  0.96
1993 Müller-Seitz M, Kaupmann K, Labeit S, Jockusch H. Chromosomal localization of the mouse titin gene and its relation to "muscular dystrophy with myositis" and nebulin genes on chromosome 2. Genomics. 18: 559-61. PMID 8307566 DOI: 10.1016/S0888-7543(05)80356-8  0.96
1993 Landwehr J, Kaupmann K, Heinrich G, Schwander J. Cloning and characterization of the gene encoding murine insulin-like growth factor-binding protein-2, mIGFBP-2. Gene. 124: 281-6. PMID 7680327 DOI: 10.1016/0378-1119(93)90406-S  0.96
1992 Wichmann H, Jockusch H, Guénet JL, Gallwitz D, Kaupmann K. The mouse homolog to the ras-related yeast gene YPT1 maps on chromosome 11 close to the wobbler (wr) locus. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 3: 467-8. PMID 1643310 DOI: 10.1007/BF00356159  0.96
1992 Kaupmann K, Becker-Follmann J, Scherer G, Jockusch H, Starzinski-Powitz A. The gene for the cell adhesion molecule M-cadherin maps to mouse chromosome 8 and human chromosome 16q24.1-qter and is near the E-cadherin (uvomorulin) locus in both species. Genomics. 14: 488-90. PMID 1427864 DOI: 10.1016/S0888-7543(05)80247-2  0.96
1992 Kaupmann K, Simon-Chazottes D, Guénet JL, Jockusch H. Wobbler, a mutation affecting motoneuron survival and gonadal functions in the mouse, maps to proximal chromosome 11. Genomics. 13: 39-43. PMID 1349581 DOI: 10.1016/0888-7543(92)90199-3  0.96
1991 Kaupmann K, Sendtner M, Stöckli KA, Jockusch H. The Gene for Ciliary Neurotrophic Factor (CNTF) Maps to Murine Chromosome 19 and its Expression is Not Affected in the Hereditary Motoneuron Disease 'Wobbler' of the Mouse. The European Journal of Neuroscience. 3: 1182-1186. PMID 12106247 DOI: 10.1111/j.1460-9568.1991.tb00052.x  0.96
1988 Kaupmann K, Jockusch H. Dolichos biflorus agglutinin receptors in mouse muscle. II. Biochemical properties in relation to molecular forms of acetylcholinesterase. European Journal of Cell Biology. 46: 419-24. PMID 3181164  0.96
1988 Kaupmann K, Heimann P, Jockusch H. Dolichos biflorus agglutinin receptors in mouse muscle. I. Developmental expression in relation to synaptic acetylcholinesterase and to neuromuscular disease. European Journal of Cell Biology. 46: 411-8. PMID 3181163  0.96
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