Year |
Citation |
Score |
2024 |
Pérez-Mitta G, Sezgin Y, Wang W, MacKinnon R. Freestanding bilayer microscope for single-molecule imaging of membrane proteins. Science Advances. 10: eado4722. PMID 38905330 DOI: 10.1126/sciadv.ado4722 |
0.789 |
|
2023 |
Mandala VS, MacKinnon R. The membrane electric field regulates the PIP-binding site to gate the KCNQ1 channel. Proceedings of the National Academy of Sciences of the United States of America. 120: e2301985120. PMID 37192161 DOI: 10.1073/pnas.2301985120 |
0.522 |
|
2023 |
Tao X, Zhao C, MacKinnon R. Membrane protein isolation and structure determination in cell-derived membrane vesicles. Proceedings of the National Academy of Sciences of the United States of America. 120: e2302325120. PMID 37098056 DOI: 10.1073/pnas.2302325120 |
0.329 |
|
2023 |
Pérez-Mitta G, MacKinnon R. Freestanding lipid bilayer tensiometer for the study of mechanosensitive ion channels. Proceedings of the National Academy of Sciences of the United States of America. 120: e2221541120. PMID 36913590 DOI: 10.1073/pnas.2221541120 |
0.836 |
|
2022 |
Mandala VS, MacKinnon R. Voltage-sensor movements in the Eag Kv channel under an applied electric field. Proceedings of the National Academy of Sciences of the United States of America. 119: e2214151119. PMID 36331999 DOI: 10.1073/pnas.2214151119 |
0.546 |
|
2022 |
Zhao C, MacKinnon R. Structural and functional analyses of a GPCR-inhibited ion channel TRPM3. Neuron. PMID 36283409 DOI: 10.1016/j.neuron.2022.10.002 |
0.42 |
|
2022 |
Zhang Y, Tao X, MacKinnon R. Correlation between structure and function in phosphatidylinositol lipid-dependent Kir2.2 gating. Proceedings of the National Academy of Sciences of the United States of America. 119: e2114046119. PMID 35286194 DOI: 10.1073/pnas.2114046119 |
0.483 |
|
2021 |
Zhao C, MacKinnon R. Molecular structure of an open human K channel. Proceedings of the National Academy of Sciences of the United States of America. 118. PMID 34815345 DOI: 10.1073/pnas.2112267118 |
0.555 |
|
2021 |
Niu Y, Tao X, Vaisey G, Olinares PDB, Alwaseem H, Chait BT, MacKinnon R. Analysis of the mechanosensor channel functionality of TACAN. Elife. 10. PMID 34374644 DOI: 10.7554/eLife.71188 |
0.534 |
|
2020 |
Niu Y, Tao X, Touhara KK, MacKinnon R. Cryo-EM analysis of PIP regulation in mammalian GIRK channels. Elife. 9. PMID 32844743 DOI: 10.7554/eLife.60552 |
0.565 |
|
2020 |
Niu Y, Tao X, Touhara KK, MacKinnon R. Author response: Cryo-EM analysis of PIP2 regulation in mammalian GIRK channels Elife. DOI: 10.7554/Elife.60552.Sa2 |
0.538 |
|
2019 |
Sun J, MacKinnon R. Structural Basis of Human KCNQ1 Modulation and Gating. Cell. PMID 31883792 DOI: 10.1016/J.Cell.2019.12.003 |
0.707 |
|
2019 |
Tao X, MacKinnon R. Molecular structures of the human Slo1 K channel in complex with β4. Elife. 8. PMID 31815672 DOI: 10.7554/eLife.51409 |
0.346 |
|
2019 |
Lee CH, MacKinnon R. Voltage Sensor Movements during Hyperpolarization in the HCN Channel. Cell. 179: 1582-1589.e7. PMID 31787376 DOI: 10.1016/j.cell.2019.11.006 |
0.645 |
|
2019 |
Tao X, MacKinnon R. Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology. Elife. 8. PMID 31755864 DOI: 10.7554/eLife.52164 |
0.56 |
|
2019 |
Brohawn SG, Wang W, Handler A, Campbell EB, Schwarz JR, MacKinnon R. The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier. Elife. 8. PMID 31674909 DOI: 10.7554/Elife.50403 |
0.797 |
|
2019 |
Whicher JR, MacKinnon R. Regulation of Eag1 gating by its intracellular domains. Elife. 8. PMID 31490124 DOI: 10.7554/eLife.49188 |
0.587 |
|
2019 |
Lin YC, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S. Force-induced conformational changes in PIEZO1. Nature. PMID 31435018 DOI: 10.1038/s41586-019-1499-2 |
0.417 |
|
2019 |
Tao X, MacKinnon R. Author response: Cryo-EM structure of the KvAP channel reveals a non-domain-swapped voltage sensor topology Elife. DOI: 10.7554/Elife.52164.Sa2 |
0.535 |
|
2019 |
MacKinnon R, Sukharev S. Decision letter: Molecular basis of force-from-lipids gating in the mechanosensitive channel MscS Elife. DOI: 10.7554/Elife.50486.Sa1 |
0.489 |
|
2019 |
Brohawn SG, Wang W, Handler A, Campbell EB, Schwarz JR, MacKinnon R. Author response: The mechanosensitive ion channel TRAAK is localized to the mammalian node of Ranvier Elife. DOI: 10.7554/Elife.50403.022 |
0.813 |
|
2019 |
Whicher JR, MacKinnon R. Author response: Regulation of Eag1 gating by its intracellular domains Elife. DOI: 10.7554/Elife.49188.026 |
0.336 |
|
2019 |
Tao X, MacKinnon R. Molecular structures of the human Slo1 K+channel in complex with beta 4. Elife. 8. DOI: 10.2210/Pdb6V22/Pdb |
0.454 |
|
2019 |
Lin Y, Guo YR, Miyagi A, Levring J, MacKinnon R, Scheuring S. Structural Response of the Piezo Channel Upon Application of Force Biophysical Journal. 116. DOI: 10.1016/J.Bpj.2018.11.1633 |
0.501 |
|
2018 |
Touhara KK, MacKinnon R. Molecular basis of signaling specificity between GIRK channels and GPCRs. Elife. 7. PMID 30526853 DOI: 10.7554/eLife.42908 |
0.376 |
|
2018 |
Haselwandter CA, MacKinnon R. Piezo's membrane footprint and its contribution to mechanosensitivity. Elife. 7. PMID 30480546 DOI: 10.7554/eLife.41968 |
0.552 |
|
2018 |
Del Mármol JI, Touhara KK, Croft G, MacKinnon R. Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells. Elife. 7. PMID 30132757 DOI: 10.7554/eLife.33149 |
0.353 |
|
2018 |
Park E, MacKinnon R. Structure of the CLC-1 chloride channel from . Elife. 7. PMID 29809153 DOI: 10.7554/Elife.36629 |
0.678 |
|
2018 |
Lee CH, MacKinnon R. Activation mechanism of a human SK-calmodulin channel complex elucidated by cryo-EM structures. Science (New York, N.Y.). 360: 508-513. PMID 29724949 DOI: 10.1126/science.aas9466 |
0.616 |
|
2018 |
Touhara KK, MacKinnon R. Author response: Molecular basis of signaling specificity between GIRK channels and GPCRs Elife. DOI: 10.7554/Elife.42908.021 |
0.489 |
|
2018 |
MacKinnon R. Decision letter: Cryo-EM structures of the DCPIB-inhibited volume-regulated anion channel LRRC8A in lipid nanodiscs Elife. DOI: 10.7554/Elife.42636.047 |
0.495 |
|
2018 |
Haselwandter CA, MacKinnon R. Author response: Piezo’s membrane footprint and its contribution to mechanosensitivity Elife. DOI: 10.7554/Elife.41968.019 |
0.306 |
|
2018 |
Park E, MacKinnon R. Author response: Structure of the CLC-1 chloride channel from Homo sapiens Elife. DOI: 10.7554/Elife.36629.031 |
0.712 |
|
2018 |
Mármol JId, Touhara KK, Croft G, MacKinnon R. Author response: Piezo1 forms a slowly-inactivating mechanosensory channel in mouse embryonic stem cells Elife. DOI: 10.7554/Elife.33149.015 |
0.469 |
|
2017 |
Lee KPK, Chen J, MacKinnon R. Molecular structure of human KATP in complex with ATP and ADP. Elife. 6. PMID 29286281 DOI: 10.7554/Elife.32481 |
0.476 |
|
2017 |
Guo YR, MacKinnon R. Structure-based membrane dome mechanism for Piezo mechanosensitivity. Elife. 6. PMID 29231809 DOI: 10.7554/eLife.33660 |
0.616 |
|
2017 |
Sun J, MacKinnon R. Cryo-EM Structure of a KCNQ1/CaM Complex Reveals Insights into Congenital Long QT Syndrome. Cell. 169: 1042-1050.e9. PMID 28575668 DOI: 10.1016/J.Cell.2017.05.019 |
0.582 |
|
2017 |
Wang W, MacKinnon R. Cryo-EM Structure of the Open Human Ether-à-go-go-Related K(+) Channel hERG. Cell. 169: 422-430.e10. PMID 28431243 DOI: 10.1016/j.cell.2017.03.048 |
0.556 |
|
2017 |
Hite RK, MacKinnon R. Structural Titration of Slo2.2, a Na(+)-Dependent K(+) Channel. Cell. 168: 390-399.e11. PMID 28111072 DOI: 10.1016/J.Cell.2016.12.030 |
0.811 |
|
2017 |
Lee CH, MacKinnon R. Structures of the Human HCN1 Hyperpolarization-Activated Channel. Cell. 168: 111-120.e11. PMID 28086084 DOI: 10.1016/j.cell.2016.12.023 |
0.665 |
|
2017 |
MacKinnon R. Ligand-Dependent Structural States of a K+Channel Analyzed by Cryo-EM Biophysical Journal. 112. DOI: 10.1016/J.Bpj.2016.11.111 |
0.603 |
|
2016 |
Park E, Campbell EB, MacKinnon R. Structure of a CLC chloride ion channel by cryo-electron microscopy. Nature. PMID 28002411 DOI: 10.1038/Nature20812 |
0.704 |
|
2016 |
Hite RK, Tao X, MacKinnon R. Structural basis for gating the high-conductance Ca(2+)-activated K(+) channel. Nature. PMID 27974801 DOI: 10.1038/Nature20775 |
0.782 |
|
2016 |
Tao X, Hite RK, MacKinnon R. Cryo-EM structure of the open high-conductance Ca(2+)-activated K(+) channel. Nature. PMID 27974795 DOI: 10.1038/Nature20608 |
0.788 |
|
2016 |
Whicher JR, MacKinnon R. Structure of the voltage-gated K⁺ channel Eag1 reveals an alternative voltage sensing mechanism. Science (New York, N.Y.). 353: 664-9. PMID 27516594 DOI: 10.1126/science.aaf8070 |
0.625 |
|
2016 |
Su Z, Brown EC, Wang W, MacKinnon R. Novel cell-free high-throughput screening method for pharmacological tools targeting K+ channels. Proceedings of the National Academy of Sciences of the United States of America. PMID 27091997 DOI: 10.1073/pnas.1602815113 |
0.566 |
|
2016 |
Touhara KK, Wang W, MacKinnon R. The GIRK1 subunit potentiates G protein activation of cardiac GIRK1/4 hetero-tetramers. Elife. 5. PMID 27074664 DOI: 10.7554/eLife.15750 |
0.501 |
|
2016 |
Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R. Cooperative regulation by G proteins and Na(+) of neuronal GIRK2 K(+) channels. Elife. 5. PMID 27074662 DOI: 10.7554/Elife.15751 |
0.663 |
|
2016 |
Wang W, Touhara KK, Weir K, Bean BP, MacKinnon R. Author response: Cooperative regulation by G proteins and Na+ of neuronal GIRK2 K+ channels Elife. DOI: 10.7554/Elife.15751.016 |
0.695 |
|
2015 |
Hite RK, Yuan P, Li Z, Hsuing Y, Walz T, MacKinnon R. Cryo-electron microscopy structure of the Slo2.2 Na(+)-activated K(+) channel. Nature. PMID 26436452 DOI: 10.1038/Nature14958 |
0.854 |
|
2014 |
Brohawn SG, Campbell EB, MacKinnon R. Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel. Nature. 516: 126-30. PMID 25471887 DOI: 10.1038/Nature14013 |
0.832 |
|
2014 |
Hite RK, Butterwick JA, MacKinnon R. Phosphatidic acid modulation of Kv channel voltage sensor function. Elife. 3. PMID 25285449 DOI: 10.7554/Elife.04366 |
0.781 |
|
2014 |
Wang W, Whorton MR, MacKinnon R. Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system. Elife. 3: e03671. PMID 25049222 DOI: 10.7554/Elife.03671 |
0.561 |
|
2014 |
Brohawn SG, Su Z, MacKinnon R. Mechanosensitivity is mediated directly by the lipid membrane in TRAAK and TREK1 K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 111: 3614-9. PMID 24550493 DOI: 10.1073/Pnas.1320768111 |
0.831 |
|
2014 |
Hite RK, Butterwick JA, MacKinnon R. Author response: Phosphatidic acid modulation of Kv channel voltage sensor function Elife. DOI: 10.7554/Elife.04366.017 |
0.771 |
|
2014 |
Wang W, Whorton MR, MacKinnon R. Author response: Quantitative analysis of mammalian GIRK2 channel regulation by G proteins, the signaling lipid PIP2 and Na+ in a reconstituted system Elife. DOI: 10.7554/Elife.03671.011 |
0.493 |
|
2013 |
Whorton MR, MacKinnon R. X-ray structure of the mammalian GIRK2-βγ G-protein complex. Nature. 498: 190-7. PMID 23739333 DOI: 10.1038/Nature12241 |
0.586 |
|
2013 |
Banerjee A, Lee A, Campbell E, Mackinnon R. Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K(+) channel. Elife. 2: e00594. PMID 23705070 DOI: 10.7554/Elife.00594 |
0.606 |
|
2013 |
Brohawn SG, Campbell EB, MacKinnon R. Domain-swapped chain connectivity and gated membrane access in a Fab-mediated crystal of the human TRAAK K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 110: 2129-34. PMID 23341632 DOI: 10.1073/Pnas.1218950110 |
0.837 |
|
2013 |
Banerjee A, Lee A, Campbell E, MacKinnon R. Author response: Structure of a pore-blocking toxin in complex with a eukaryotic voltage-dependent K+ channel Elife. DOI: 10.7554/Elife.00594.018 |
0.597 |
|
2013 |
MacKinnon R, Butterwick J, Letts JL. Biophysical Studies of the Voltage-Dependent Proton Channel Biophysical Journal. 104: 34a. DOI: 10.1016/j.bpj.2012.11.226 |
0.643 |
|
2012 |
Leonetti MD, Yuan P, Hsiung Y, Mackinnon R. Functional and structural analysis of the human SLO3 pH- and voltage-gated K+ channel. Proceedings of the National Academy of Sciences of the United States of America. 109: 19274-9. PMID 23129643 DOI: 10.1073/pnas.1215078109 |
0.563 |
|
2012 |
Feng L, Campbell EB, MacKinnon R. Molecular mechanism of proton transport in CLC Cl-/H+ exchange transporters. Proceedings of the National Academy of Sciences of the United States of America. 109: 11699-704. PMID 22753511 DOI: 10.1073/Pnas.1205764109 |
0.504 |
|
2012 |
Schmidt D, del Mármol J, MacKinnon R. Mechanistic basis for low threshold mechanosensitivity in voltage-dependent K+ channels. Proceedings of the National Academy of Sciences of the United States of America. 109: 10352-7. PMID 22675122 DOI: 10.1073/pnas.1204700109 |
0.664 |
|
2012 |
Brohawn SG, del Mármol J, MacKinnon R. Crystal structure of the human K2P TRAAK, a lipid- and mechano-sensitive K+ ion channel. Science (New York, N.Y.). 335: 436-41. PMID 22282805 DOI: 10.1126/Science.1213808 |
0.841 |
|
2012 |
Yuan P, Leonetti MD, Hsiung Y, MacKinnon R. Open structure of the Ca2+ gating ring in the high-conductance Ca2+-activated K+ channel. Nature. 481: 94-7. PMID 22139424 DOI: 10.1038/nature10670 |
0.523 |
|
2011 |
Whorton MR, MacKinnon R. Crystal structure of the mammalian GIRK2 K+ channel and gating regulation by G proteins, PIP2, and sodium. Cell. 147: 199-208. PMID 21962516 DOI: 10.1016/J.Cell.2011.07.046 |
0.591 |
|
2011 |
Hansen SB, Tao X, MacKinnon R. Structural basis of PIP2 activation of the classical inward rectifier K+ channel Kir2.2. Nature. 477: 495-8. PMID 21874019 DOI: 10.1038/Nature10370 |
0.635 |
|
2010 |
Feng L, Campbell EB, Hsiung Y, MacKinnon R. Structure of a eukaryotic CLC transporter defines an intermediate state in the transport cycle. Science (New York, N.Y.). 330: 635-41. PMID 20929736 DOI: 10.1126/Science.1195230 |
0.567 |
|
2010 |
Butterwick JA, MacKinnon R. Solution structure and phospholipid interactions of the isolated voltage-sensor domain from KvAP. Journal of Molecular Biology. 403: 591-606. PMID 20851706 DOI: 10.1016/j.jmb.2010.09.012 |
0.523 |
|
2010 |
Love J, Mancia F, Shapiro L, Punta M, Rost B, Girvin M, Wang DN, Zhou M, Hunt JF, Szyperski T, Gouaux E, MacKinnon R, McDermott A, Honig B, Inouye M, et al. The New York Consortium on Membrane Protein Structure (NYCOMPS): a high-throughput platform for structural genomics of integral membrane proteins. Journal of Structural and Functional Genomics. 11: 191-9. PMID 20690043 DOI: 10.1007/S10969-010-9094-7 |
0.409 |
|
2010 |
Yuan P, Leonetti MD, Pico AR, Hsiung Y, MacKinnon R. Structure of the human BK channel Ca2+-activation apparatus at 3.0 A resolution. Science (New York, N.Y.). 329: 182-6. PMID 20508092 DOI: 10.1126/Science.1190414 |
0.718 |
|
2010 |
Tao X, Lee A, Limapichat W, Dougherty DA, MacKinnon R. A gating charge transfer center in voltage sensors. Science (New York, N.Y.). 328: 67-73. PMID 20360102 DOI: 10.1126/Science.1185954 |
0.478 |
|
2010 |
MacKinnon R. The Structural Basis of Voltage Sensing Biophysical Journal. 98: 754a. DOI: 10.1016/j.bpj.2009.12.4137 |
0.372 |
|
2009 |
Tao X, Avalos JL, Chen J, MacKinnon R. Crystal structure of the eukaryotic strong inward-rectifier K+ channel Kir2.2 at 3.1 A resolution. Science (New York, N.Y.). 326: 1668-74. PMID 20019282 DOI: 10.1126/Science.1180310 |
0.634 |
|
2009 |
Endeward B, Butterwick JA, MacKinnon R, Prisner TF. Pulsed electron-electron double-resonance determination of spin-label distances and orientations on the tetrameric potassium ion channel KcsA. Journal of the American Chemical Society. 131: 15246-50. PMID 19919160 DOI: 10.1021/Ja904808N |
0.379 |
|
2009 |
Schmidt D, Cross SR, MacKinnon R. A gating model for the archeal voltage-dependent K(+) channel KvAP in DPhPC and POPE:POPG decane lipid bilayers. Journal of Molecular Biology. 390: 902-12. PMID 19481093 DOI: 10.1016/j.jmb.2009.05.062 |
0.648 |
|
2009 |
Lee SY, Banerjee A, MacKinnon R. Two separate interfaces between the voltage sensor and pore are required for the function of voltage-dependent K(+) channels. Plos Biology. 7: e47. PMID 19260762 DOI: 10.1371/Journal.Pbio.1000047 |
0.678 |
|
2009 |
Lee SY, Letts JA, MacKinnon R. Functional reconstitution of purified human Hv1 H+ channels. Journal of Molecular Biology. 387: 1055-60. PMID 19233200 DOI: 10.1016/J.Jmb.2009.02.034 |
0.732 |
|
2009 |
Lee SY, Banerjee A, Mackinnon R. Two separate interfaces between the Voltage sensor and pore are required for the function of Voltage-dependent K+ channels Plos Biology. 7: 0676-0686. DOI: 10.1371/journal.pbio.1000047-S.pdf |
0.64 |
|
2008 |
Schmidt D, MacKinnon R. Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Proceedings of the National Academy of Sciences of the United States of America. 105: 19276-81. PMID 19050073 DOI: 10.1073/pnas.0810187105 |
0.637 |
|
2008 |
Tao X, MacKinnon R. Functional analysis of Kv1.2 and paddle chimera Kv channels in planar lipid bilayers. Journal of Molecular Biology. 382: 24-33. PMID 18638484 DOI: 10.1016/j.jmb.2008.06.085 |
0.667 |
|
2008 |
Banerjee A, MacKinnon R. Inferred motions of the S3a helix during voltage-dependent K+ channel gating. Journal of Molecular Biology. 381: 569-80. PMID 18632115 DOI: 10.1016/J.Jmb.2008.06.010 |
0.535 |
|
2008 |
Lee SY, Letts JA, Mackinnon R. Dimeric subunit stoichiometry of the human voltage-dependent proton channel Hv1. Proceedings of the National Academy of Sciences of the United States of America. 105: 7692-5. PMID 18509058 DOI: 10.1073/Pnas.0803277105 |
0.686 |
|
2007 |
Long SB, Tao X, Campbell EB, MacKinnon R. Atomic structure of a voltage-dependent K+ channel in a lipid membrane-like environment. Nature. 450: 376-82. PMID 18004376 DOI: 10.1038/Nature06265 |
0.781 |
|
2007 |
Nishida M, Cadene M, Chait BT, MacKinnon R. Crystal structure of a Kir3.1-prokaryotic Kir channel chimera. The Embo Journal. 26: 4005-15. PMID 17703190 DOI: 10.1038/Sj.Emboj.7601828 |
0.632 |
|
2007 |
Lockless SW, Zhou M, MacKinnon R. Structural and thermodynamic properties of selective ion binding in a K+ channel. Plos Biology. 5: e121. PMID 17472437 DOI: 10.1371/Journal.Pbio.0050121 |
0.807 |
|
2006 |
Schmidt D, Jiang QX, MacKinnon R. Phospholipids and the origin of cationic gating charges in voltage sensors. Nature. 444: 775-9. PMID 17136096 DOI: 10.1038/nature05416 |
0.711 |
|
2006 |
Valiyaveetil FI, Leonetti M, Muir TW, Mackinnon R. Ion selectivity in a semisynthetic K+ channel locked in the conductive conformation. Science (New York, N.Y.). 314: 1004-7. PMID 17095703 DOI: 10.1126/Science.1133415 |
0.566 |
|
2006 |
Valiyaveetil FI, Sekedat M, MacKinnon R, Muir TW. Structural and functional consequences of an amide-to-ester substitution in the selectivity filter of a potassium channel. Journal of the American Chemical Society. 128: 11591-9. PMID 16939283 DOI: 10.1021/Ja0631955 |
0.498 |
|
2005 |
Gouaux E, Mackinnon R. Principles of selective ion transport in channels and pumps. Science (New York, N.Y.). 310: 1461-5. PMID 16322449 DOI: 10.1126/science.1113666 |
0.456 |
|
2005 |
Ruta V, Chen J, MacKinnon R. Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K+ channel. Cell. 123: 463-75. PMID 16269337 DOI: 10.1016/j.cell.2005.08.041 |
0.849 |
|
2005 |
Lee SY, Lee A, Chen J, MacKinnon R. Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane. Proceedings of the National Academy of Sciences of the United States of America. 102: 15441-6. PMID 16223877 DOI: 10.1073/Pnas.0507651102 |
0.694 |
|
2005 |
Long SB, Campbell EB, Mackinnon R. Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science (New York, N.Y.). 309: 897-903. PMID 16002581 DOI: 10.1126/Science.1116269 |
0.8 |
|
2005 |
Long SB, Campbell EB, Mackinnon R. Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science (New York, N.Y.). 309: 903-8. PMID 16002579 DOI: 10.1126/Science.1116270 |
0.782 |
|
2005 |
Ohndorf UM, MacKinnon R. Construction of a cyclic nucleotide-gated KcsA K+ channel. Journal of Molecular Biology. 350: 857-65. PMID 15979092 DOI: 10.1016/j.jmb.2005.05.050 |
0.658 |
|
2005 |
Mackinnon R. Structural biology. Membrane protein insertion and stability. Science (New York, N.Y.). 307: 1425-6. PMID 15746418 DOI: 10.1126/science.1110525 |
0.338 |
|
2004 |
MacKinnon R. Nobel Lecture. Potassium channels and the atomic basis of selective ion conduction. Bioscience Reports. 24: 75-100. PMID 15628664 DOI: 10.1007/s10540-004-7190-2 |
0.502 |
|
2004 |
Valiyaveetil FI, Sekedat M, Mackinnon R, Muir TW. Glycine as a D-amino acid surrogate in the K(+)-selectivity filter. Proceedings of the National Academy of Sciences of the United States of America. 101: 17045-9. PMID 15563591 DOI: 10.1073/Pnas.0407820101 |
0.36 |
|
2004 |
Mackinnon R. Structural biology. Voltage sensor meets lipid membrane. Science (New York, N.Y.). 306: 1304-5. PMID 15550651 DOI: 10.1126/science.1105528 |
0.508 |
|
2004 |
MacKinnon R. Potassium channels and the atomic basis of selective ion conduction (Nobel Lecture). Angewandte Chemie (International Ed. in English). 43: 4265-77. PMID 15368373 DOI: 10.1002/anie.200400662 |
0.444 |
|
2004 |
Jiang QX, Wang DN, MacKinnon R. Electron microscopic analysis of KvAP voltage-dependent K+ channels in an open conformation. Nature. 430: 806-10. PMID 15306816 DOI: 10.1038/Nature02735 |
0.772 |
|
2004 |
Ruta V, MacKinnon R. Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry. 43: 10071-9. PMID 15287735 DOI: 10.1021/bi049463y |
0.813 |
|
2004 |
Lee SY, MacKinnon R. A membrane-access mechanism of ion channel inhibition by voltage sensor toxins from spider venom. Nature. 430: 232-5. PMID 15241419 DOI: 10.1038/Nature02632 |
0.676 |
|
2004 |
Valiyaveetil FI, Sekedat M, Muir TW, MacKinnon R. Semisynthesis of a functional K+ channel. Angewandte Chemie (International Ed. in English). 43: 2504-7. PMID 15127436 DOI: 10.1002/Anie.200453849 |
0.581 |
|
2004 |
Zhou Y, MacKinnon R. Ion binding affinity in the cavity of the KcsA potassium channel. Biochemistry. 43: 4978-82. PMID 15109256 DOI: 10.1021/bi049876z |
0.537 |
|
2004 |
Zhou M, MacKinnon R. A mutant KcsA K(+) channel with altered conduction properties and selectivity filter ion distribution. Journal of Molecular Biology. 338: 839-46. PMID 15099749 DOI: 10.1016/J.Jmb.2004.03.020 |
0.519 |
|
2003 |
MacKinnon R. Potassium channels. Febs Letters. 555: 62-5. PMID 14630320 DOI: 10.1016/S0014-5793(03)01104-9 |
0.585 |
|
2003 |
Zhou Y, MacKinnon R. The occupancy of ions in the K+ selectivity filter: charge balance and coupling of ion binding to a protein conformational change underlie high conduction rates. Journal of Molecular Biology. 333: 965-75. PMID 14583193 DOI: 10.1016/j.jmb.2003.09.022 |
0.444 |
|
2003 |
Jiang Y, Ruta V, Chen J, Lee A, MacKinnon R. The principle of gating charge movement in a voltage-dependent K+ channel. Nature. 423: 42-8. PMID 12721619 DOI: 10.1038/Nature01581 |
0.867 |
|
2003 |
Jiang Y, Lee A, Chen J, Ruta V, Cadene M, Chait BT, MacKinnon R. X-ray structure of a voltage-dependent K+ channel. Nature. 423: 33-41. PMID 12721618 DOI: 10.1038/Nature01580 |
0.876 |
|
2003 |
Dutzler R, Campbell EB, MacKinnon R. Gating the selectivity filter in ClC chloride channels. Science (New York, N.Y.). 300: 108-12. PMID 12649487 DOI: 10.1126/science.1082708 |
0.612 |
|
2003 |
Ruta V, Jiang Y, Lee A, Chen J, MacKinnon R. Functional analysis of an archaebacterial voltage-dependent K+ channel. Nature. 422: 180-5. PMID 12629550 DOI: 10.1038/Nature01473 |
0.878 |
|
2002 |
Nishida M, MacKinnon R. Structural basis of inward rectification: cytoplasmic pore of the G protein-gated inward rectifier GIRK1 at 1.8 A resolution. Cell. 111: 957-65. PMID 12507423 DOI: 10.1016/S0092-8674(02)01227-8 |
0.644 |
|
2002 |
Yifrach O, MacKinnon R. Energetics of pore opening in a voltage-gated K(+) channel. Cell. 111: 231-9. PMID 12408867 DOI: 10.1016/S0092-8674(02)01013-9 |
0.632 |
|
2002 |
Valiyaveetil FI, Zhou Y, MacKinnon R. Lipids in the structure, folding, and function of the KcsA K+ channel. Biochemistry. 41: 10771-7. PMID 12196015 DOI: 10.1021/bi026215y |
0.554 |
|
2002 |
Valiyaveetil FI, MacKinnon R, Muir TW. Semisynthesis and folding of the potassium channel KcsA. Journal of the American Chemical Society. 124: 9113-20. PMID 12149015 DOI: 10.1021/Ja0266722 |
0.357 |
|
2002 |
Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R. The open pore conformation of potassium channels. Nature. 417: 523-6. PMID 12037560 DOI: 10.1038/417523A |
0.818 |
|
2002 |
Jiang Y, Lee A, Chen J, Cadene M, Chait BT, MacKinnon R. Crystal structure and mechanism of a calcium-gated potassium channel. Nature. 417: 515-22. PMID 12037559 DOI: 10.1038/417515A |
0.82 |
|
2002 |
MacKinnon R. Nothing automatic about ion-channel structures. Nature. 416: 261-2. PMID 11907549 DOI: 10.1038/416261b |
0.581 |
|
2002 |
Dutzler R, Campbell EB, Cadene M, Chait BT, MacKinnon R. X-ray structure of a ClC chloride channel at 3.0 A reveals the molecular basis of anion selectivity. Nature. 415: 287-94. PMID 11796999 DOI: 10.1038/415287A |
0.579 |
|
2002 |
Cadene M, Dutzler R, MacKinnon R, Chait BT. Mass spectrometry for the crystallization of the chloride channel Proceedings 50th Asms Conference On Mass Spectrometry and Allied Topics. 107. |
0.36 |
|
2001 |
Zhou Y, Morais-Cabral JH, Kaufman A, MacKinnon R. Chemistry of ion coordination and hydration revealed by a K+ channel-Fab complex at 2.0 A resolution. Nature. 414: 43-8. PMID 11689936 DOI: 10.1038/35102009 |
0.541 |
|
2001 |
Morais-Cabral JH, Zhou Y, MacKinnon R. Energetic optimization of ion conduction rate by the K+ selectivity filter. Nature. 414: 37-42. PMID 11689935 DOI: 10.1038/35102000 |
0.419 |
|
2001 |
Zhou M, Morais-Cabral JH, Mann S, MacKinnon R. Potassium channel receptor site for the inactivation gate and quaternary amine inhibitors. Nature. 411: 657-61. PMID 11395760 DOI: 10.1038/35079500 |
0.706 |
|
2001 |
Jiang Y, Pico A, Cadene M, Chait BT, MacKinnon R. Structure of the RCK domain from the E. coli K+ channel and demonstration of its presence in the human BK channel. Neuron. 29: 593-601. PMID 11301020 DOI: 10.1016/S0896-6273(01)00236-7 |
0.819 |
|
2000 |
Gulbis JM, Zhou M, Mann S, MacKinnon R. Structure of the cytoplasmic beta subunit-T1 assembly of voltage-dependent K+ channels. Science (New York, N.Y.). 289: 123-7. PMID 10884227 DOI: 10.1126/Science.289.5476.123 |
0.541 |
|
2000 |
Imredy JP, MacKinnon R. Energetic and structural interactions between delta-dendrotoxin and a voltage-gated potassium channel. Journal of Molecular Biology. 296: 1283-94. PMID 10698633 DOI: 10.1006/jmbi.2000.3522 |
0.642 |
|
2000 |
Jiang Y, MacKinnon R. The barium site in a potassium channel by x-ray crystallography. The Journal of General Physiology. 115: 269-72. PMID 10694255 DOI: 10.1085/Jgp.115.3.269 |
0.738 |
|
1999 |
Hille B, Armstrong CM, MacKinnon R. Ion channels: from idea to reality. Nature Medicine. 5: 1105-9. PMID 10502800 DOI: 10.1038/13415 |
0.58 |
|
1999 |
Gulbis JM, Mann S, MacKinnon R. Structure of a voltage-dependent K+ channel beta subunit. Cell. 97: 943-52. PMID 10399921 DOI: 10.1016/S0092-8674(00)80805-3 |
0.57 |
|
1999 |
Morrill JA, MacKinnon R. Isolation of a single carboxyl-carboxylate proton binding site in the pore of a cyclic nucleotide-gated channel. The Journal of General Physiology. 114: 71-83. PMID 10398693 DOI: 10.1085/jgp.114.1.71 |
0.532 |
|
1999 |
Roux B, MacKinnon R. The cavity and pore helices in the KcsA K+ channel: electrostatic stabilization of monovalent cations. Science (New York, N.Y.). 285: 100-2. PMID 10390357 DOI: 10.1126/Science.285.5424.100 |
0.6 |
|
1998 |
Morais Cabral JH, Lee A, Cohen SL, Chait BT, Li M, Mackinnon R. Crystal structure and functional analysis of the HERG potassium channel N terminus: a eukaryotic PAS domain. Cell. 95: 649-55. PMID 9845367 DOI: 10.1016/S0092-8674(00)81635-9 |
0.538 |
|
1998 |
Imredy JP, Chen C, MacKinnon R. A snake toxin inhibitor of inward rectifier potassium channel ROMK1. Biochemistry. 37: 14867-74. PMID 9778362 DOI: 10.1021/bi980929k |
0.639 |
|
1998 |
Doyle DA, Morais Cabral J, Pfuetzner RA, Kuo A, Gulbis JM, Cohen SL, Chait BT, MacKinnon R. The structure of the potassium channel: molecular basis of K+ conduction and selectivity. Science (New York, N.Y.). 280: 69-77. PMID 9525859 DOI: 10.1126/Science.280.5360.69 |
0.761 |
|
1998 |
MacKinnon R, Cohen SL, Kuo A, Lee A, Chait BT. Structural conservation in prokaryotic and eukaryotic potassium channels. Science (New York, N.Y.). 280: 106-9. PMID 9525854 DOI: 10.1126/Science.280.5360.106 |
0.637 |
|
1997 |
MacKinnon R, Doyle DA. Prokaryotes offer hope for potassium channel structural studies. Nature Structural Biology. 4: 877-9. PMID 9360597 DOI: 10.1038/Nsb1197-877 |
0.795 |
|
1997 |
Lu Z, MacKinnon R. Purification, characterization, and synthesis of an inward-rectifier K+ channel inhibitor from scorpion venom. Biochemistry. 36: 6936-40. PMID 9188688 DOI: 10.1021/bi9702849 |
0.617 |
|
1997 |
Swartz KJ, MacKinnon R. Mapping the receptor site for hanatoxin, a gating modifier of voltage-dependent K+ channels. Neuron. 18: 675-82. PMID 9136775 DOI: 10.1016/S0896-6273(00)80307-4 |
0.6 |
|
1997 |
Swartz KJ, MacKinnon R. Hanatoxin modifies the gating of a voltage-dependent K+ channel through multiple binding sites. Neuron. 18: 665-73. PMID 9136774 DOI: 10.1016/S0896-6273(00)80306-2 |
0.661 |
|
1996 |
Gross A, MacKinnon R. Agitoxin footprinting the shaker potassium channel pore. Neuron. 16: 399-406. PMID 8789954 DOI: 10.1016/S0896-6273(00)80057-4 |
0.513 |
|
1996 |
Doyle DA, Lee A, Lewis J, Kim E, Sheng M, MacKinnon R. Crystal structures of a complexed and peptide-free membrane protein-binding domain: molecular basis of peptide recognition by PDZ. Cell. 85: 1067-76. PMID 8674113 DOI: 10.1016/S0092-8674(00)81307-0 |
0.663 |
|
1996 |
Aggarwal SK, MacKinnon R. Contribution of the S4 segment to gating charge in the Shaker K+ channel. Neuron. 16: 1169-77. PMID 8663993 DOI: 10.1016/S0896-6273(00)80143-9 |
0.582 |
|
1996 |
Ranganathan R, Lewis JH, MacKinnon R. Spatial localization of the K+ channel selectivity filter by mutant cycle-based structure analysis. Neuron. 16: 131-9. PMID 8562077 DOI: 10.1016/S0896-6273(00)80030-6 |
0.749 |
|
1995 |
Krezel AM, Kasibhatla C, Hidalgo P, MacKinnon R, Wagner G. Solution structure of the potassium channel inhibitor agitoxin 2: caliper for probing channel geometry. Protein Science : a Publication of the Protein Society. 4: 1478-89. PMID 8520473 DOI: 10.1002/pro.5560040805 |
0.612 |
|
1995 |
Hidalgo P, MacKinnon R. Revealing the architecture of a K+ channel pore through mutant cycles with a peptide inhibitor. Science (New York, N.Y.). 268: 307-10. PMID 7716527 DOI: 10.1126/Science.7716527 |
0.564 |
|
1995 |
Park CS, MacKinnon R. Divalent cation selectivity in a cyclic nucleotide-gated ion channel. Biochemistry. 34: 13328-33. PMID 7577917 DOI: 10.1021/Bi00041A008 |
0.551 |
|
1995 |
Swartz KJ, MacKinnon R. An inhibitor of the Kv2.1 potassium channel isolated from the venom of a Chilean tarantula. Neuron. 15: 941-9. PMID 7576642 DOI: 10.1016/0896-6273(95)90184-1 |
0.599 |
|
1995 |
Lu Z, MacKinnon R. Probing a potassium channel pore with an engineered protonatable site. Biochemistry. 34: 13133-8. PMID 7548074 DOI: 10.1021/Bi00040A026 |
0.628 |
|
1995 |
MacKinnon R. Pore loops: an emerging theme in ion channel structure. Neuron. 14: 889-92. PMID 7538310 DOI: 10.1016/0896-6273(95)90327-5 |
0.583 |
|
1994 |
Garcia ML, Garcia-Calvo M, Hidalgo P, Lee A, MacKinnon R. Purification and characterization of three inhibitors of voltage-dependent K+ channels from Leiurus quinquestriatus var. hebraeus venom. Biochemistry. 33: 6834-9. PMID 8204618 DOI: 10.1021/Bi00188A012 |
0.57 |
|
1994 |
Heginbotham L, Lu Z, Abramson T, MacKinnon R. Mutations in the K+ channel signature sequence. Biophysical Journal. 66: 1061-7. PMID 8038378 DOI: 10.1016/S0006-3495(94)80887-2 |
0.563 |
|
1994 |
Gross A, Abramson T, MacKinnon R. Transfer of the scorpion toxin receptor to an insensitive potassium channel. Neuron. 13: 961-6. PMID 7946339 DOI: 10.1016/0896-6273(94)90261-5 |
0.628 |
|
1994 |
Lu Z, MacKinnon R. Electrostatic tuning of Mg2+ affinity in an inward-rectifier K+ channel. Nature. 371: 243-6. PMID 7915826 DOI: 10.1038/371243a0 |
0.621 |
|
1994 |
Lu Z, MacKinnon R. A conductance maximum observed in an inward-rectifier potassium channel. The Journal of General Physiology. 104: 477-86. PMID 7807057 DOI: 10.1085/Jgp.104.3.477 |
0.606 |
|
1994 |
Root MJ, MacKinnon R. Two identical noninteracting sites in an ion channel revealed by proton transfer. Science (New York, N.Y.). 265: 1852-6. PMID 7522344 DOI: 10.1126/Science.7522344 |
0.573 |
|
1993 |
Perozo E, MacKinnon R, Bezanilla F, Stefani E. Gating currents from a nonconducting mutant reveal open-closed conformations in Shaker K+ channels. Neuron. 11: 353-8. PMID 8352943 DOI: 10.1016/0896-6273(93)90190-3 |
0.662 |
|
1993 |
Heginbotham L, MacKinnon R. Conduction properties of the cloned Shaker K+ channel. Biophysical Journal. 65: 2089-96. PMID 8298038 DOI: 10.1016/S0006-3495(93)81244-X |
0.583 |
|
1993 |
MacKinnon R, Aldrich RW, Lee AW. Functional stoichiometry of Shaker potassium channel inactivation. Science (New York, N.Y.). 262: 757-9. PMID 7694359 DOI: 10.1126/Science.7694359 |
0.586 |
|
1993 |
Root MJ, MacKinnon R. Identification of an external divalent cation-binding site in the pore of a cGMP-activated channel. Neuron. 11: 459-66. PMID 7691102 DOI: 10.1016/0896-6273(93)90150-P |
0.618 |
|
1993 |
Escobar L, Root MJ, MacKinnon R. Influence of protein surface charge on the bimolecular kinetics of a potassium channel peptide inhibitor. Biochemistry. 32: 6982-7. PMID 7687466 DOI: 10.1021/Bi00078A024 |
0.525 |
|
1992 |
Heginbotham L, MacKinnon R. The aromatic binding site for tetraethylammonium ion on potassium channels. Neuron. 8: 483-91. PMID 1550673 DOI: 10.1016/0896-6273(92)90276-J |
0.593 |
|
1992 |
Heginbotham L, Abramson T, MacKinnon R. A functional connection between the pores of distantly related ion channels as revealed by mutant K+ channels. Science (New York, N.Y.). 258: 1152-5. PMID 1279807 DOI: 10.1126/Science.1279807 |
0.667 |
|
1991 |
Yellen G, Jurman ME, Abramson T, MacKinnon R. Mutations affecting internal TEA blockade identify the probable pore-forming region of a K+ channel. Science (New York, N.Y.). 251: 939-42. PMID 2000494 DOI: 10.1126/Science.2000494 |
0.834 |
|
1991 |
MacKinnon R. Using mutagenesis to study potassium channel mechanisms. Journal of Bioenergetics and Biomembranes. 23: 647-63. PMID 1917912 DOI: 10.1007/BF00785815 |
0.676 |
|
1991 |
MacKinnon R. New insights into the structure and function of potassium channels. Current Opinion in Neurobiology. 1: 14-9. PMID 1822292 DOI: 10.1016/0959-4388(91)90005-R |
0.606 |
|
1991 |
MacKinnon R. Determination of the subunit stoichiometry of a voltage-activated potassium channel. Nature. 350: 232-5. PMID 1706481 DOI: 10.1038/350232a0 |
0.659 |
|
1990 |
MacKinnon R, Yellen G. Mutations affecting TEA blockade and ion permeation in voltage-activated K+ channels. Science (New York, N.Y.). 250: 276-9. PMID 2218530 DOI: 10.1126/Science.2218530 |
0.85 |
|
1990 |
MacKinnon R, Heginbotham L, Abramson T. Mapping the receptor site for charybdotoxin, a pore-blocking potassium channel inhibitor. Neuron. 5: 767-71. PMID 1702643 DOI: 10.1016/0896-6273(90)90335-D |
0.643 |
|
1990 |
Schumaker MF, MacKinnon R. A simple model for multi-ion permeation. Single-vacancy conduction in a simple pore model. Biophysical Journal. 58: 975-84. PMID 1701102 DOI: 10.1016/S0006-3495(90)82442-5 |
0.537 |
|
1989 |
MacKinnon R, Latorre R, Miller C. Role of surface electrostatics in the operation of a high-conductance Ca2+-activated K+ channel. Biochemistry. 28: 8092-9. PMID 2605175 DOI: 10.1021/Bi00446A020 |
0.692 |
|
1989 |
MacKinnon R, Miller C. Functional modification of a Ca2+-activated K+ channel by trimethyloxonium. Biochemistry. 28: 8087-92. PMID 2481495 DOI: 10.1021/Bi00446A019 |
0.715 |
|
1989 |
MacKinnon R, Miller C. Mutant potassium channels with altered binding of charybdotoxin, a pore-blocking peptide inhibitor. Science (New York, N.Y.). 245: 1382-5. PMID 2476850 DOI: 10.1126/Science.2476850 |
0.61 |
|
1988 |
MacKinnon R, Reinhart PH, White MM. Charybdotoxin block of Shaker K+ channels suggests that different types of K+ channels share common structural features. Neuron. 1: 997-1001. PMID 2483094 DOI: 10.1016/0896-6273(88)90156-0 |
0.718 |
|
1988 |
MacKinnon R, Miller C. Mechanism of charybdotoxin block of the high-conductance, Ca2+-activated K+ channel. The Journal of General Physiology. 91: 335-49. PMID 2454283 DOI: 10.1085/Jgp.91.3.335 |
0.556 |
|
1988 |
Anderson CS, MacKinnon R, Smith C, Miller C. Charybdotoxin block of single Ca2+-activated K+ channels. Effects of channel gating, voltage, and ionic strength. The Journal of General Physiology. 91: 317-33. PMID 2454282 DOI: 10.1085/Jgp.91.3.317 |
0.653 |
|
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