Alex Straiker - Publications

Indiana University, Bloomington, Bloomington, IN, United States 
Neuroscience, GPCRs, Cannabinoids

66 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2023 Straiker A, Dvorakova M, Bosquez-Berger T, Blahos J, Mackie K. A collection of cannabinoid-related negative findings from autaptic hippocampal neurons. Scientific Reports. 13: 9610. PMID 37311900 DOI: 10.1038/s41598-023-36710-3  0.341
2022 Bosquez T, Wilson S, Iliopoulos-Tsoutsouvas C, Jiang S, Wager-Miller J, Nikas SP, Mackie KP, Makriyannis A, Straiker A. Differential enantiomer-specific signaling of cannabidiol at CB receptors. Molecular Pharmacology. PMID 36153039 DOI: 10.1124/molpharm.121.000305  0.454
2022 Dvorakova M, Wilson S, Corey W, Billingsley J, Zimmowitch A, Tracey J, Straiker A, Mackie K. A Critical Evaluation of Terpenoid Signaling at Cannabinoid CB1 Receptors in a Neuronal Model. Molecules (Basel, Switzerland). 27. PMID 36080421 DOI: 10.3390/molecules27175655  0.407
2022 Andreis K, Billingsley J, Naimi Shirazi K, Wager-Miller J, Johnson C, Bradshaw H, Straiker A. Cannabinoid CB1 receptors regulate salivation. Scientific Reports. 12: 14182. PMID 35986066 DOI: 10.1038/s41598-022-17987-2  0.43
2021 Straiker A, Wilson S, Corey W, Dvorakova M, Bosquez T, Tracey J, Wilkowski C, Ho K, Wager-Miller J, Mackie K. An Evaluation of Understudied Phytocannabinoids and Their Effects in Two Neuronal Models. Molecules (Basel, Switzerland). 26. PMID 34500785 DOI: 10.3390/molecules26175352  0.312
2021 Dvorakova M, Kubik-Zahorodna A, Straiker A, Sedlacek R, Hajkova A, Mackie K, Blahos J. SGIP1 is involved in regulation of emotionality, mood, and nociception and tunes in vivo signaling of Cannabinoid Receptor 1. British Journal of Pharmacology. PMID 33491188 DOI: 10.1111/bph.15383  0.697
2020 Miller S, Daily L, Ploss M, Greig I, Ross R, Rayana NP, Dai J, Sugali CK, Mao W, Straiker A. Evidence that cannabinoid CB1 receptors regulate intraocular pressure via two opposing mechanisms. Experimental Eye Research. 108241. PMID 32941875 DOI: 10.1016/j.exer.2020.108241  0.511
2020 Thayer A, Murataeva N, Delcroix V, Wager-Miller J, Makarenkova HP, Straiker A. THC Regulates Tearing via Cannabinoid CB1 Receptors. Investigative Ophthalmology & Visual Science. 61: 48. PMID 32852544 DOI: 10.1167/Iovs.61.10.48  0.774
2019 Garai S, Kulkarni PM, Schaffer PC, Leo L, Brandt AL, Zagzoog A, Black T, Lin X, Hurst DP, Janero DR, Abood ME, Zimmowitch A, Straiker A, Pertwee RG, Kelly M, et al. Application of Fluorine- And Nitrogen-Walk Approaches: Defining the Structural and Functional Diversity of 2-Phenylindole Class of CB1 Receptor Positive Allosteric Modulators. Journal of Medicinal Chemistry. PMID 31756109 DOI: 10.1021/Acs.Jmedchem.9B01142  0.699
2019 Wang ZJ, Hu SS, Bradshaw HB, Sun L, Mackie K, Straiker A, Heinbockel T. Cannabinoid Receptor-Mediated Modulation of Inhibitory Inputs to Mitral Cells in the Main Olfactory Bulb. Journal of Neurophysiology. PMID 31215302 DOI: 10.1152/Jn.00100.2018  0.741
2019 Murataeva N, Daily L, Taylor X, Dhopeshwarkar A, Hu SS, Miller S, McHugh D, Oehler O, Li S, Bonanno JA, Mackie K, Straiker A. Evidence for a GPR18 Role in Chemotaxis, Proliferation, and the Course of Wound Closure in the Cornea. Cornea. PMID 30969262 DOI: 10.1097/Ico.0000000000001934  0.793
2019 Murataeva N, Miller S, Dhopeshwarkar A, Leishman E, Daily L, Taylor X, Morton B, Lashmet M, Bradshaw H, Hillard CJ, Romero J, Straiker A. Cannabinoid CB2R receptors are upregulated with corneal injury and regulate the course of corneal wound healing. Experimental Eye Research. PMID 30905716 DOI: 10.1016/J.Exer.2019.03.011  0.818
2018 Miller S, Daily L, Leishman E, Bradshaw H, Straiker A. Δ9-Tetrahydrocannabinol and Cannabidiol Differentially Regulate Intraocular Pressure. Investigative Ophthalmology & Visual Science. 59: 5904-5911. PMID 30550613 DOI: 10.1167/iovs.18-24838  0.443
2018 Alapafuja SO, Malamas MS, Shukla V, Zvonok A, Miller S, Daily L, Rajarshi G, Miyabe CY, Chandrashekhar H, Wood J, Tyukhtenko S, Straiker A, Makriyannis A. Synthesis and evaluation of potent and selective MGL inhibitors as a glaucoma treatment. Bioorganic & Medicinal Chemistry. PMID 30446439 DOI: 10.1016/J.Bmc.2018.11.003  0.39
2018 Borowska-Fielding J, Murataeva N, Smith B, Szczesniak AM, Leishmann E, Daily L, Toguri T, Hillard C, Romero J, Bradshaw H, Kelly M, Straiker A. Revisiting cannabinoid receptor 2 expression and function in murine retina. Neuropharmacology. PMID 30121200 DOI: 10.1016/J.Neuropharm.2018.08.007  0.807
2018 Miller S, Kulkarni S, Ciesielski A, Nikas SP, Mackie K, Makriyannis A, Straiker A. Controlled-Deactivation CB1 Receptor Ligands as a Novel Strategy to Lower Intraocular Pressure. Pharmaceuticals (Basel, Switzerland). 11. PMID 29786643 DOI: 10.3390/Ph11020050  0.743
2018 Straiker A, Dvorakova M, Zimmowitch A, Mackie KP. Cannabidiol inhibits endocannabinoid signaling in autaptic hippocampal neurons. Molecular Pharmacology. PMID 29669714 DOI: 10.1124/mol.118.111864  0.753
2017 Mitjavila J, Yin D, Kulkarni PM, Zanato C, Thakur GA, Ross R, Greig I, Mackie K, Straiker A. Enantiomer-specific positive allosteric modulation of CB1 signaling in autaptic hippocampal neurons. Pharmacological Research. PMID 29158048 DOI: 10.1016/j.phrs.2017.11.019  0.739
2017 Cairns EA, Szczesniak AM, Straiker AJ, Kulkarni PM, Pertwee RG, Thakur GA, Baldridge WH, Kelly MEM. The In Vivo Effects of the CB1-Positive Allosteric Modulator GAT229 on Intraocular Pressure in Ocular Normotensive and Hypertensive Mice. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. PMID 28719234 DOI: 10.1089/jop.2017.0037  0.312
2017 Ruehle S, Wager-Miller J, Straiker A, Farnsworth J, Murphy MN, Loch S, Monory K, Mackie K, Lutz B. Discovery and characterization of two novel CB1 receptor splice variants with modified N-termini in mouse. Journal of Neurochemistry. PMID 28608535 DOI: 10.1111/jnc.14099  0.742
2017 Miller S, Hu SS, Leishman E, Morgan D, Wager-Miller J, Mackie K, Bradshaw HB, Straiker A. A GPR119 Signaling System in the Murine Eye Regulates Intraocular Pressure in a Sex-Dependent Manner. Investigative Ophthalmology & Visual Science. 58: 2930-2938. PMID 28593245 DOI: 10.1167/iovs.16-21330  0.734
2016 Dhopeshwarkar A, Murataeva N, Makriyannis A, Straiker A, Mackie KP. Two Janus cannabinoids that are both CB2 agonists and CB1 antagonists. The Journal of Pharmacology and Experimental Therapeutics. PMID 27927913 DOI: 10.1124/Jpet.116.236539  0.823
2016 Miller S, Leishman E, Oehler O, Daily L, Murataeva N, Wager-Miller J, Bradshaw H, Straiker A. Evidence for a GPR18 Role in Diurnal Regulation of Intraocular Pressure. Investigative Ophthalmology & Visual Science. 57: 6419-6426. PMID 27893106 DOI: 10.1167/Iovs.16-19437  0.745
2016 Miller S, Leishman E, Hu SS, Elghouche A, Daily L, Murataeva N, Bradshaw H, Straiker A. Harnessing the Endocannabinoid 2-Arachidonoylglycerol to Lower Intraocular Pressure in a Murine Model. Investigative Ophthalmology & Visual Science. 57: 3287-3296. PMID 27333182 DOI: 10.1167/Iovs.16-19356  0.814
2016 Murataeva N, Dhopeshwarkar A, Yin D, Mitjavila J, Bradshaw H, Straiker A, Mackie K. WHERE's MY ENTOURAGE? THE CURIOUS CASE OF 2-oleoylglycerol, 2-linolenoylglycerol, and 2-palmitoylglycerol. Pharmacological Research. PMID 27117667 DOI: 10.1016/J.Phrs.2016.04.015  0.807
2016 Leishman E, Cornett B, Spork K, Straiker A, Mackie K, Bradshaw HB. Broad impact of deleting endogenous cannabinoid hydrolyzing enzymes and the CB1 cannabinoid receptor on the endogenous cannabinoid-related lipidome in eight regions of the mouse brain. Pharmacological Research. PMID 27109320 DOI: 10.1016/j.phrs.2016.04.020  0.64
2015 Straiker A, Mitjavila J, Yin D, Gibson A, Mackie K. Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model. Pharmacological Research. 99: 370-6. PMID 26211948 DOI: 10.1016/j.phrs.2015.07.017  0.722
2015 Murataeva N, Li S, Oehler O, Miller S, Dhopeshwarkar A, Hu SS, Bonanno JA, Bradshaw H, Mackie K, McHugh D, Straiker A. Cannabinoid-induced chemotaxis in bovine corneal epithelial cells. Investigative Ophthalmology & Visual Science. 56: 3304-13. PMID 26024113 DOI: 10.1167/Iovs.14-15675  0.805
2015 Smith TH, Blume LC, Straiker A, Cox JO, David BG, McVoy JR, Sayers KW, Poklis JL, Abdullah RA, Egertová M, Chen CK, Mackie K, Elphick MR, Howlett AC, Selley DE. Cannabinoid receptor-interacting protein 1a modulates CB1 receptor signaling and regulation. Molecular Pharmacology. 87: 747-65. PMID 25657338 DOI: 10.1124/Mol.114.096495  0.725
2015 Keenan CM, Storr MA, Thakur GA, Wood JT, Wager-Miller J, Straiker A, Eno MR, Nikas SP, Bashashati M, Hu H, Mackie K, Makriyannis A, Sharkey KA. AM841, a covalent cannabinoid ligand, powerfully slows gastrointestinal motility in normal and stressed mice in a peripherally restricted manner. British Journal of Pharmacology. 172: 2406-18. PMID 25572435 DOI: 10.1111/Bph.13069  0.66
2015 Straiker A, Mitjavila J, Yin D, Gibson A, Mackie K. Aiming for allosterism: Evaluation of allosteric modulators of CB1 in a neuronal model Pharmacological Research. 99: 370-376. DOI: 10.1016/j.phrs.2015.07.017  0.592
2014 MacIntyre J, Dong A, Straiker A, Zhu J, Howlett SE, Bagher A, Denovan-Wright E, Yu DY, Kelly ME. Cannabinoid and lipid-mediated vasorelaxation in retinal microvasculature. European Journal of Pharmacology. 735: 105-14. PMID 24751709 DOI: 10.1016/J.Ejphar.2014.03.055  0.407
2014 Morgan DJ, Davis BJ, Kearn CS, Marcus D, Cook AJ, Wager-Miller J, Straiker A, Myoga MH, Karduck J, Leishman E, Sim-Selley LJ, Czyzyk TA, Bradshaw HB, Selley DE, Mackie K. Mutation of putative GRK phosphorylation sites in the cannabinoid receptor 1 (CB1R) confers resistance to cannabinoid tolerance and hypersensitivity to cannabinoids in mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 34: 5152-63. PMID 24719095 DOI: 10.1523/Jneurosci.3445-12.2014  0.814
2014 Murataeva N, Straiker A, Mackie K. Parsing the players: 2-arachidonoylglycerol synthesis and degradation in the CNS. British Journal of Pharmacology. 171: 1379-91. PMID 24102242 DOI: 10.1111/Bph.12411  0.772
2013 Jain T, Wager-Miller J, Mackie K, Straiker A. Diacylglycerol lipaseα (DAGLα) and DAGLβ cooperatively regulate the production of 2-arachidonoyl glycerol in autaptic hippocampal neurons. Molecular Pharmacology. 84: 296-302. PMID 23748223 DOI: 10.1124/mol.113.085217  0.719
2013 Straiker A, Min KT, Mackie K. Fmr1 deletion enhances and ultimately desensitizes CB(1) signaling in autaptic hippocampal neurons. Neurobiology of Disease. 56: 1-5. PMID 23578490 DOI: 10.1016/J.Nbd.2013.04.002  0.718
2013 Wu CS, Chen H, Sun H, Zhu J, Jew CP, Wager-Miller J, Straiker A, Spencer C, Bradshaw H, Mackie K, Lu HC. GPR55, a G-protein coupled receptor for lysophosphatidylinositol, plays a role in motor coordination. Plos One. 8: e60314. PMID 23565223 DOI: 10.1371/journal.pone.0060314  0.638
2013 Caldwell MD, Hu SS, Viswanathan S, Bradshaw H, Kelly ME, Straiker A. A GPR18-based signalling system regulates IOP in murine eye. British Journal of Pharmacology. 169: 834-43. PMID 23461720 DOI: 10.1111/bph.12136  0.653
2012 Murataeva N, Mackie K, Straiker A. The CB2-preferring agonist JWH015 also potently and efficaciously activates CB1 in autaptic hippocampal neurons. Pharmacological Research : the Official Journal of the Italian Pharmacological Society. 66: 437-42. PMID 22921769 DOI: 10.1016/J.Phrs.2012.08.002  0.825
2012 Atwood BK, Straiker A, Mackie K. CBâ‚‚ cannabinoid receptors inhibit synaptic transmission when expressed in cultured autaptic neurons. Neuropharmacology. 63: 514-23. PMID 22579668 DOI: 10.1016/J.Neuropharm.2012.04.024  0.795
2012 Keimpema E, Straiker A, Mackie K, Harkany T, Hjerling-Leffler J. Sticking out of the crowd: the molecular identity and development of cholecystokinin-containing basket cells. The Journal of Physiology. 590: 703-14. PMID 22219340 DOI: 10.1113/Jphysiol.2011.224386  0.615
2012 Atwood BK, Straiker A, Mackie K. CBâ‚‚: therapeutic target-in-waiting. Progress in Neuro-Psychopharmacology & Biological Psychiatry. 38: 16-20. PMID 22197668 DOI: 10.1016/J.Pnpbp.2011.12.001  0.796
2012 Grabiec U, Koch M, Kallendrusch S, Kraft R, Hill K, Merkwitz C, Ghadban C, Lutz B, Straiker A, Dehghani F. The endocannabinoid N-arachidonoyldopamine (NADA) exerts neuroprotective effects after excitotoxic neuronal damage via cannabinoid receptor 1 (CB(1)). Neuropharmacology. 62: 1797-807. PMID 22186081 DOI: 10.1016/j.neuropharm.2011.11.023  0.504
2012 Atwood BK, Wager-Miller J, Haskins C, Straiker A, Mackie K. Functional selectivity in CB(2) cannabinoid receptor signaling and regulation: implications for the therapeutic potential of CB(2) ligands. Molecular Pharmacology. 81: 250-63. PMID 22064678 DOI: 10.1124/Mol.111.074013  0.839
2012 Straiker A, Wager-Miller J, Hutchens J, Mackie K. Differential signalling in human cannabinoid CB1 receptors and their splice variants in autaptic hippocampal neurones. British Journal of Pharmacology. 165: 2660-71. PMID 22014238 DOI: 10.1111/j.1476-5381.2011.01744.x  0.765
2012 Straiker A, Wager-Miller J, Mackie K. The CB1 cannabinoid receptor C-terminus regulates receptor desensitization in autaptic hippocampal neurones. British Journal of Pharmacology. 165: 2652-9. PMID 22014214 DOI: 10.1111/j.1476-5381.2011.01743.x  0.752
2011 Hudson BD, Beazley M, Szczesniak AM, Straiker A, Kelly ME. Indirect sympatholytic actions at β-adrenoceptors account for the ocular hypotensive actions of cannabinoid receptor agonists. The Journal of Pharmacology and Experimental Therapeutics. 339: 757-67. PMID 21885619 DOI: 10.1124/jpet.111.185769  0.511
2011 Straiker A, Wager-Miller J, Hu SS, Blankman JL, Cravatt BF, Mackie K. COX-2 and fatty acid amide hydrolase can regulate the time course of depolarization-induced suppression of excitation. British Journal of Pharmacology. 164: 1672-83. PMID 21564090 DOI: 10.1111/J.1476-5381.2011.01486.X  0.679
2011 Atwood BK, Lee D, Straiker A, Widlanski TS, Mackie K. CP47,497-C8 and JWH073, commonly found in 'Spice' herbal blends, are potent and efficacious CB(1) cannabinoid receptor agonists. European Journal of Pharmacology. 659: 139-45. PMID 21333643 DOI: 10.1016/J.Ejphar.2011.01.066  0.825
2011 Atwood BK, Lopez J, Wager-Miller J, Mackie K, Straiker A. Expression of G protein-coupled receptors and related proteins in HEK293, AtT20, BV2, and N18 cell lines as revealed by microarray analysis. Bmc Genomics. 12: 14. PMID 21214938 DOI: 10.1186/1471-2164-12-14  0.785
2010 Hu SS, Arnold A, Hutchens JM, Radicke J, Cravatt BF, Wager-Miller J, Mackie K, Straiker A. Architecture of cannabinoid signaling in mouse retina. The Journal of Comparative Neurology. 518: 3848-66. PMID 20653038 DOI: 10.1002/Cne.22429  0.766
2010 Atwood BK, Huffman J, Straiker A, Mackie K. JWH018, a common constituent of 'Spice' herbal blends, is a potent and efficacious cannabinoid CB receptor agonist. British Journal of Pharmacology. 160: 585-93. PMID 20100276 DOI: 10.1111/J.1476-5381.2009.00582.X  0.847
2009 Straiker A, Hu SS, Long JZ, Arnold A, Wager-Miller J, Cravatt BF, Mackie K. Monoacylglycerol lipase limits the duration of endocannabinoid-mediated depolarization-induced suppression of excitation in autaptic hippocampal neurons. Molecular Pharmacology. 76: 1220-7. PMID 19767452 DOI: 10.1124/Mol.109.059030  0.741
2009 Straiker A, Mackie K. Cannabinoid signaling in inhibitory autaptic hippocampal neurons. Neuroscience. 163: 190-201. PMID 19501632 DOI: 10.1016/j.neuroscience.2009.06.004  0.692
2009 Kellogg R, Mackie K, Straiker A. Cannabinoid CB1 receptor-dependent long-term depression in autaptic excitatory neurons. Journal of Neurophysiology. 102: 1160-71. PMID 19494194 DOI: 10.1152/jn.00266.2009  0.719
2008 Moussaieff A, Rimmerman N, Bregman T, Straiker A, Felder CC, Shoham S, Kashman Y, Huang SM, Lee H, Shohami E, Mackie K, Caterina MJ, Walker JM, Fride E, Mechoulam R. Incensole acetate, an incense component, elicits psychoactivity by activating TRPV3 channels in the brain. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 22: 3024-34. PMID 18492727 DOI: 10.1096/Fj.07-101865  0.646
2007 Straiker A, Mackie K. Metabotropic suppression of excitation in murine autaptic hippocampal neurons. The Journal of Physiology. 578: 773-85. PMID 17110416 DOI: 10.1113/jphysiol.2006.117499  0.756
2006 Straiker A, Mackie K. Cannabinoids, electrophysiology, and retrograde messengers: challenges for the next 5 years. The Aaps Journal. 8: E272-6. PMID 16796377 DOI: 10.1208/aapsj080231  0.72
2006 Witting A, Chen L, Cudaback E, Straiker A, Walter L, Rickman B, Möller T, Brosnan C, Stella N. Experimental autoimmune encephalomyelitis disrupts endocannabinoid-mediated neuroprotection. Proceedings of the National Academy of Sciences of the United States of America. 103: 6362-7. PMID 16571660 DOI: 10.1073/Pnas.0510418103  0.439
2005 Straiker A, Mackie K. Depolarization-induced suppression of excitation in murine autaptic hippocampal neurones. The Journal of Physiology. 569: 501-17. PMID 16179366 DOI: 10.1113/jphysiol.2005.091918  0.708
2003 Straiker A, Sullivan JM. Cannabinoid receptor activation differentially modulates ion channels in photoreceptors of the tiger salamander. Journal of Neurophysiology. 89: 2647-54. PMID 12740409 DOI: 10.1152/jn.00268.2002  0.628
2002 Straiker AJ, Borden CR, Sullivan JM. G-protein alpha subunit isoforms couple differentially to receptors that mediate presynaptic inhibition at rat hippocampal synapses. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 2460-8. PMID 11923410  0.734
2000 Lu Q, Straiker A, Lu Q, Maguire G. Expression of CB2 cannabinoid receptor mRNA in adult rat retina. Visual Neuroscience. 17: 91-5. PMID 10750830 DOI: 10.1017/S0952523800171093  0.664
1999 Straiker A, Stella N, Piomelli D, Mackie K, Karten HJ, Maguire G. Cannabinoid CB1 receptors and ligands in vertebrate retina: localization and function of an endogenous signaling system. Proceedings of the National Academy of Sciences of the United States of America. 96: 14565-70. PMID 10588745 DOI: 10.1073/Pnas.96.25.14565  0.76
1999 Straiker AJ, Maguire G, Mackie K, Lindsey J. Localization of cannabinoid CB1 receptors in the human anterior eye and retina. Investigative Ophthalmology & Visual Science. 40: 2442-8. PMID 10476817  0.587
1999 Maguire G, Straiker A, Chauder D, Haamedi SN, Piomelli D, Stella N, Lu QJ. Neural circuitry and plasticity in the adult vertebrate inner retina Lecture Notes in Computer Science (Including Subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics). 1606: 65-72. DOI: 10.1007/BFb0098161  0.453
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