Joseph W. Lewcock, Ph.D. - Publications

Johns Hopkins University, Baltimore, MD 

24 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Andreone BJ, Przybyla L, Llapashtica C, Rana A, Davis SS, van Lengerich B, Lin K, Shi J, Mei Y, Astarita G, Di Paolo G, Sandmann T, Monroe KM, Lewcock JW. Alzheimer's-associated PLCγ2 is a signaling node required for both TREM2 function and the inflammatory response in human microglia. Nature Neuroscience. PMID 32514138 DOI: 10.1038/s41593-020-0650-6  0.32
2019 Nugent AA, Lin K, van Lengerich B, Lianoglou S, Przybyla L, Davis SS, Llapashtica C, Wang J, Kim DJ, Xia D, Lucas A, Baskaran S, Haddick PCG, Lenser M, Earr TK, ... ... Lewcock JW, et al. TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge. Neuron. PMID 31902528 DOI: 10.1016/j.neuron.2019.12.007  0.32
2019 Fang MY, Markmiller S, Vu AQ, Javaherian A, Dowdle WE, Jolivet P, Bushway PJ, Castello NA, Baral A, Chan MY, Linsley JW, Linsley D, Mercola M, Finkbeiner S, Lecuyer E, ... Lewcock JW, et al. Small-Molecule Modulation of TDP-43 Recruitment to Stress Granules Prevents Persistent TDP-43 Accumulation in ALS/FTD. Neuron. PMID 31272829 DOI: 10.1016/j.neuron.2019.05.048  0.32
2019 Naguib A, Sandmann T, Yi F, Watts RJ, Lewcock JW, Dowdle WE. SUPT4H1 Depletion Leads to a Global Reduction in RNA. Cell Reports. 26: 45-53.e4. PMID 30605685 DOI: 10.1016/j.celrep.2018.12.004  0.32
2015 Patel S, Harris SF, Gibbons P, Deshmukh G, Gustafson A, Kellar T, Lin H, Liu X, Liu Y, Liu Y, Ma C, Scearce-Levie K, Ghosh AS, Shin YG, Solanoy H, ... ... Lewcock JW, et al. Scaffold-Hopping and Structure-Based Discovery of Potent, Selective, And Brain Penetrant N-(1H-Pyrazol-3-yl)pyridin-2-amine Inhibitors of Dual Leucine Zipper Kinase (DLK, MAP3K12). Journal of Medicinal Chemistry. PMID 26431428 DOI: 10.1021/acs.jmedchem.5b01072  0.84
2015 Rudhard Y, Sengupta Ghosh A, Lippert B, Böcker A, Pedaran M, Krämer J, Ngu H, Foreman O, Liu Y, Lewcock JW. Identification of 12/15-lipoxygenase as a regulator of axon degeneration through high-content screening. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 35: 2927-41. PMID 25698732 DOI: 10.1523/JNEUROSCI.2936-14.2015  0.84
2015 Patel S, Cohen F, Dean BJ, De La Torre K, Deshmukh G, Estrada AA, Ghosh AS, Gibbons P, Gustafson A, Huestis MP, Le Pichon CE, Lin H, Liu W, Liu X, Liu Y, ... ... Lewcock JW, et al. Discovery of dual leucine zipper kinase (DLK, MAP3K12) inhibitors with activity in neurodegeneration models. Journal of Medicinal Chemistry. 58: 401-18. PMID 25341110 DOI: 10.1021/jm5013984  0.84
2013 Lobsiger CS, Boillée S, Pozniak C, Khan AM, McAlonis-Downes M, Lewcock JW, Cleveland DW. C1q induction and global complement pathway activation do not contribute to ALS toxicity in mutant SOD1 mice. Proceedings of the National Academy of Sciences of the United States of America. 110: E4385-92. PMID 24170856 DOI: 10.1073/pnas.1318309110  0.84
2013 Pozniak CD, Sengupta Ghosh A, Gogineni A, Hanson JE, Lee SH, Larson JL, Solanoy H, Bustos D, Li H, Ngu H, Jubb AM, Ayalon G, Wu J, Scearce-Levie K, Zhou Q, ... ... Lewcock JW, et al. Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration. The Journal of Experimental Medicine. 210: 2553-67. PMID 24166713 DOI: 10.1084/jem.20122832  0.84
2013 Huntwork-Rodriguez S, Wang B, Watkins T, Ghosh AS, Pozniak CD, Bustos D, Newton K, Kirkpatrick DS, Lewcock JW. JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis. The Journal of Cell Biology. 202: 747-63. PMID 23979718 DOI: 10.1083/jcb.201303066  0.84
2013 Watkins TA, Wang B, Huntwork-Rodriguez S, Yang J, Jiang Z, Eastham-Anderson J, Modrusan Z, Kaminker JS, Tessier-Lavigne M, Lewcock JW. DLK initiates a transcriptional program that couples apoptotic and regenerative responses to axonal injury. Proceedings of the National Academy of Sciences of the United States of America. 110: 4039-44. PMID 23431164 DOI: 10.1073/pnas.1211074110  0.84
2012 Heise CE, Murray J, Augustyn KE, Bravo B, Chugha P, Cohen F, Giannetti AM, Gibbons P, Hannoush RN, Hearn BR, Jaishankar P, Ly CQ, Shah K, Stanger K, Steffek M, ... ... Lewcock JW, et al. Mechanistic and structural understanding of uncompetitive inhibitors of caspase-6. Plos One. 7: e50864. PMID 23227217 DOI: 10.1371/journal.pone.0050864  0.84
2012 Chen M, Maloney JA, Kallop DY, Atwal JK, Tam SJ, Baer K, Kissel H, Kaminker JS, Lewcock JW, Weimer RM, Watts RJ. Spatially coordinated kinase signaling regulates local axon degeneration. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 32: 13439-53. PMID 23015435 DOI: 10.1523/JNEUROSCI.2039-12.2012  0.84
2012 Stanger K, Steffek M, Zhou L, Pozniak CD, Quan C, Franke Y, Tom J, Tam C, Krylova I, Elliott JM, Lewcock JW, Zhang Y, Murray J, Hannoush RN. Allosteric peptides bind a caspase zymogen and mediate caspase tetramerization. Nature Chemical Biology. 8: 655-60. PMID 22683611 DOI: 10.1038/nchembio.967  0.84
2012 Mintzer R, Ramaswamy S, Shah K, Hannoush RN, Pozniak CD, Cohen F, Zhao X, Plise E, Lewcock JW, Heise CE. A whole cell assay to measure caspase-6 activity by detecting cleavage of lamin A/C. Plos One. 7: e30376. PMID 22253931 DOI: 10.1371/journal.pone.0030376  0.84
2011 Ghosh AS, Wang B, Pozniak CD, Chen M, Watts RJ, Lewcock JW. DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity. The Journal of Cell Biology. 194: 751-64. PMID 21893599 DOI: 10.1083/jcb.201103153  0.84
2011 Bai G, Chivatakarn O, Bonanomi D, Lettieri K, Franco L, Xia C, Stein E, Ma L, Lewcock JW, Pfaff SL. Presenilin-dependent receptor processing is required for axon guidance. Cell. 144: 106-18. PMID 21215373 DOI: 10.1016/j.cell.2010.11.053  0.84
2007 Lewcock JW, Genoud N, Lettieri K, Pfaff SL. The ubiquitin ligase Phr1 regulates axon outgrowth through modulation of microtubule dynamics. Neuron. 56: 604-20. PMID 18031680 DOI: 10.1016/j.neuron.2007.09.009  0.84
2006 Shirasaki R, Lewcock JW, Lettieri K, Pfaff SL. FGF as a target-derived chemoattractant for developing motor axons genetically programmed by the LIM code. Neuron. 50: 841-53. PMID 16772167 DOI: 10.1016/j.neuron.2006.04.030  0.84
2005 Myers CP, Lewcock JW, Hanson MG, Gosgnach S, Aimone JB, Gage FH, Lee KF, Landmesser LT, Pfaff SL. Cholinergic input is required during embryonic development to mediate proper assembly of spinal locomotor circuits. Neuron. 46: 37-49. PMID 15820692 DOI: 10.1016/j.neuron.2005.02.022  0.84
2004 Wang SS, Lewcock JW, Feinstein P, Mombaerts P, Reed RR. Genetic disruptions of O/E2 and O/E3 genes reveal involvement in olfactory receptor neuron projection. Development (Cambridge, England). 131: 1377-88. PMID 14993187 DOI: 10.1242/dev.01009  0.84
2004 Lewcock JW, Reed RR. A feedback mechanism regulates monoallelic odorant receptor expression. Proceedings of the National Academy of Sciences of the United States of America. 101: 1069-74. PMID 14732684 DOI: 10.1073/pnas.0307986100  0.84
2003 Lewcock JW, Reed RR. Neuroscience. ORs rule the roost in the olfactory system. Science (New York, N.Y.). 302: 2078-9. PMID 14684811 DOI: 10.1126/science.1093397  0.84
2001 Lewcock JW, Reed RR. Sweet successes. Neuron. 31: 515-7. PMID 11545710 DOI: 10.1016/S0896-6273(01)00404-4  0.84
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