Gabriel M. Simon, Ph.D. - Publications

2009 Scripps Research Institute, La Jolla, La Jolla, CA, United States 
Medicinal Chemistry

65 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2021 Zhang X, Luukkonen LM, Eissler CL, Crowley VM, Yamashita Y, Schafroth MA, Kikuchi S, Weinstein DS, Symons KT, Nordin BE, Rodriguez JL, Wucherpfennig TG, Bauer LG, Dix MM, Stamos D, ... ... Simon GM, et al. DCAF11 Supports Targeted Protein Degradation by Electrophilic Proteolysis-Targeting Chimeras. Journal of the American Chemical Society. PMID 33783207 DOI: 10.1021/jacs.1c00990  1
2020 László ZI, Lele Z, Zöldi M, Miczán V, Mógor F, Simon GM, Mackie K, Kacskovics I, Cravatt BF, Katona I. ABHD4-dependent developmental anoikis safeguards the embryonic brain. Nature Communications. 11: 4363. PMID 32868797 DOI: 10.1038/S41467-020-18175-4  1
2020 Vinogradova EV, Zhang X, Remillard D, Lazar DC, Suciu RM, Wang Y, Bianco G, Yamashita Y, Crowley VM, Schafroth MA, Yokoyama M, Konrad DB, Lum KM, Simon GM, Kemper EK, et al. An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. PMID 32730809 DOI: 10.1016/J.Cell.2020.07.001  1
2019 Chen AL, Lum KM, Lara-Gonzalez P, Ogasawara D, Cognetta AB, To A, Parsons WH, Simon GM, Desai A, Petrascheck M, Bar-Peled L, Cravatt BF. Pharmacological convergence reveals a lipid pathway that regulates C. elegans lifespan. Nature Chemical Biology. PMID 30911178 DOI: 10.1038/S41589-019-0243-4  1
2018 Clapper JR, Henry CL, Niphakis MJ, Knize AM, Coppola AR, Simon GM, Ngo N, Herbst RA, Herbst DM, Reed AW, Cisar JS, Weber OD, Viader A, Alexander JP, Cunningham ML, et al. Monoacylglycerol Lipase Inhibition in Human and Rodent Systems Supports Clinical Evaluation of Endocannabinoid Modulators. The Journal of Pharmacology and Experimental Therapeutics. PMID 30305428 DOI: 10.1124/Jpet.118.252296  0.84
2017 Whitby LR, Obach RS, Simon GM, Hayward MM, Cravatt BF. Quantitative Chemical Proteomic Profiling of the in Vivo Targets of Reactive Drug Metabolites. Acs Chemical Biology. PMID 28636309 DOI: 10.1021/Acschembio.7B00346  1
2015 Lee HC, Simon GM, Cravatt BF. ABHD4 regulates multiple classes of N-acyl phospholipids in the mammalian central nervous system. Biochemistry. 54: 2539-49. PMID 25853435 DOI: 10.1021/Acs.Biochem.5B00207  1
2014 Lysenko LV, Kim J, Henry C, Tyrtyshnaia A, Kohnz RA, Madamba F, Simon GM, Kleschevnikova NE, Nomura DK, Ezekowitz RA, Kleschevnikov AM. Monoacylglycerol lipase inhibitor JZL184 improves behavior and neural properties in Ts65Dn mice, a model of down syndrome. Plos One. 9: e114521. PMID 25474204 DOI: 10.1371/Journal.Pone.0114521  1
2014 Seedorf H, Griffin NW, Ridaura VK, Reyes A, Cheng J, Rey FE, Smith MI, Simon GM, Scheffrahn RH, Woebken D, Spormann AM, Van Treuren W, Ursell LK, Pirrung M, Robbins-Pianka A, et al. Bacteria from diverse habitats colonize and compete in the mouse gut. Cell. 159: 253-66. PMID 25284151 DOI: 10.1016/J.Cell.2014.09.008  1
2014 Dix MM, Simon GM, Cravatt BF. Global identification of caspase substrates using PROTOMAP (protein topography and migration analysis platform). Methods in Molecular Biology (Clifton, N.J.). 1133: 61-70. PMID 24567094 DOI: 10.1007/978-1-4939-0357-3_3  1
2013 Simon GM, Niphakis MJ, Cravatt BF. Determining target engagement in living systems. Nature Chemical Biology. 9: 200-5. PMID 23508173 DOI: 10.1038/Nchembio.1211  1
2012 McNulty SN, Abubucker S, Simon GM, Mitreva M, McNulty NP, Fischer K, Curtis KC, Brattig NW, Weil GJ, Fischer PU. Transcriptomic and proteomic analyses of a Wolbachia-free filarial parasite provide evidence of trans-kingdom horizontal gene transfer. Plos One. 7: e45777. PMID 23049857 DOI: 10.1371/Journal.Pone.0045777  1
2012 Dix MM, Simon GM, Wang C, Okerberg E, Patricelli MP, Cravatt BF. Functional interplay between caspase cleavage and phosphorylation sculpts the apoptotic proteome. Cell. 150: 426-40. PMID 22817901 DOI: 10.1016/J.Cell.2012.05.040  1
2012 Simon GM, Cheng J, Gordon JI. Quantitative assessment of the impact of the gut microbiota on lysine epsilon-acetylation of host proteins using gnotobiotic mice. Proceedings of the National Academy of Sciences of the United States of America. 109: 11133-8. PMID 22733758 DOI: 10.1073/Pnas.1208669109  1
2011 Bowyer PW, Simon GM, Cravatt BF, Bogyo M. Global profiling of proteolysis during rupture of Plasmodium falciparum from the host erythrocyte. Molecular & Cellular Proteomics : McP. 10: M110.001636. PMID 20943600 DOI: 10.1074/Mcp.M110.001636  1
2010 Weerapana E, Wang C, Simon GM, Richter F, Khare S, Dillon MB, Bachovchin DA, Mowen K, Baker D, Cravatt BF. Quantitative reactivity profiling predicts functional cysteines in proteomes. Nature. 468: 790-5. PMID 21085121 DOI: 10.1038/Nature09472  1
2010 Bachovchin DA, Ji T, Li W, Simon GM, Blankman JL, Adibekian A, Hoover H, Niessen S, Cravatt BF. Superfamily-wide portrait of serine hydrolase inhibition achieved by library-versus-library screening. Proceedings of the National Academy of Sciences of the United States of America. 107: 20941-6. PMID 21084632 DOI: 10.1073/Pnas.1011663107  1
2010 Gaultier A, Simon G, Niessen S, Dix M, Takimoto S, Cravatt BF, Gonias SL. LDL receptor-related protein 1 regulates the abundance of diverse cell-signaling proteins in the plasma membrane proteome. Journal of Proteome Research. 9: 6689-95. PMID 20919742 DOI: 10.1021/Pr1008288  1
2010 Kopp F, Komatsu T, Nomura DK, Trauger SA, Thomas JR, Siuzdak G, Simon GM, Cravatt BF. The glycerophospho metabolome and its influence on amino acid homeostasis revealed by brain metabolomics of GDE1(-/-) mice. Chemistry & Biology. 17: 831-40. PMID 20797612 DOI: 10.1016/J.Chembiol.2010.06.009  1
2010 Simon GM, Cravatt BF. Characterization of mice lacking candidate N-acyl ethanolamine biosynthetic enzymes provides evidence for multiple pathways that contribute to endocannabinoid production in vivo. Molecular Biosystems. 6: 1411-8. PMID 20393650 DOI: 10.1039/C000237B  1
2010 Simon GM, Cravatt BF. Activity-based proteomics of enzyme superfamilies: serine hydrolases as a case study. The Journal of Biological Chemistry. 285: 11051-5. PMID 20147750 DOI: 10.1074/Jbc.R109.097600  1
2010 Sipe JC, Scott TM, Murray S, Harismendy O, Simon GM, Cravatt BF, Waalen J. Biomarkers of endocannabinoid system activation in severe obesity. Plos One. 5: e8792. PMID 20098695 DOI: 10.1371/Journal.Pone.0008792  1
2009 Goldenfeld M, Melamed S, Simon G, Ben Simon GJ. Titanium:Sapphire laser trabeculoplasty versus argon laser trabeculoplasty in patients with open-angle glaucoma Ophthalmic Surgery Lasers and Imaging. 40: 264-269. PMID 19485290 DOI: 10.3928/15428877-20090430-07  1
2009 Simon GM, Dix MM, Cravatt BF. Comparative assessment of large-scale proteomic studies of apoptotic proteolysis. Acs Chemical Biology. 4: 401-8. PMID 19415908 DOI: 10.1021/Cb900082Q  1
2009 Melamed S, Ben Simon GJ, Goldenfeld M, Simon G. Efficacy and safety of gold micro shunt implantation to the supraciliary space in patients with glaucoma: A pilot study Archives of Ophthalmology. 127: 264-269. PMID 19273788 DOI: 10.1001/archophthalmol.2008.611  1
2008 Simon GM, Cravatt BF. Challenges for the 'chemical-systems' biologist. Nature Chemical Biology. 4: 639-42. PMID 18936742 DOI: 10.1038/Nchembio1108-639  1
2008 Dix MM, Simon GM, Cravatt BF. Global mapping of the topography and magnitude of proteolytic events in apoptosis. Cell. 134: 679-91. PMID 18724940 DOI: 10.1016/J.Cell.2008.06.038  1
2008 Weerapana E, Simon GM, Cravatt BF. Disparate proteome reactivity profiles of carbon electrophiles. Nature Chemical Biology. 4: 405-7. PMID 18488014 DOI: 10.1038/Nchembio.91  1
2008 Nomura DK, Blankman JL, Simon GM, Fujioka K, Issa RS, Ward AM, Cravatt BF, Casida JE. Activation of the endocannabinoid system by organophosphorus nerve agents. Nature Chemical Biology. 4: 373-8. PMID 18438404 DOI: 10.1038/Nchembio.86  1
2008 Simon GM, Cravatt BF. Anandamide biosynthesis catalyzed by the phosphodiesterase GDE1 and detection of glycerophospho-N-acyl ethanolamine precursors in mouse brain. The Journal of Biological Chemistry. 283: 9341-9. PMID 18227059 DOI: 10.1074/Jbc.M707807200  1
2008 Egertová M, Simon GM, Cravatt BF, Elphick MR. Localization of N-acyl phosphatidylethanolamine phospholipase D (NAPE-PLD) expression in mouse brain: A new perspective on N-acylethanolamines as neural signaling molecules. The Journal of Comparative Neurology. 506: 604-15. PMID 18067139 DOI: 10.1002/Cne.21568  1
2007 Blankman JL, Simon GM, Cravatt BF. A comprehensive profile of brain enzymes that hydrolyze the endocannabinoid 2-arachidonoylglycerol. Chemistry & Biology. 14: 1347-56. PMID 18096503 DOI: 10.1016/J.Chembiol.2007.11.006  1
2007 Cravatt BF, Simon GM, Yates JR. The biological impact of mass-spectrometry-based proteomics. Nature. 450: 991-1000. PMID 18075578 DOI: 10.1038/Nature06525  1
2007 Hanson SR, Hsu TL, Weerapana E, Kishikawa K, Simon GM, Cravatt BF, Wong CH. Tailored glycoproteomics and glycan site mapping using saccharide-selective bioorthogonal probes. Journal of the American Chemical Society. 129: 7266-7. PMID 17506567 DOI: 10.1021/Ja0724083  1
2006 Simon GM, Cravatt BF. Endocannabinoid biosynthesis proceeding through glycerophospho-N-acyl ethanolamine and a role for alpha/beta-hydrolase 4 in this pathway. The Journal of Biological Chemistry. 281: 26465-72. PMID 16818490 DOI: 10.1074/Jbc.M604660200  1
2006 Leung D, Saghatelian A, Simon GM, Cravatt BF. Inactivation of N-acyl phosphatidylethanolamine phospholipase D reveals multiple mechanisms for the biosynthesis of endocannabinoids. Biochemistry. 45: 4720-6. PMID 16605240 DOI: 10.1021/Bi060163L  1
2004 Kossodo S, Wong WR, Simon G, Kochevar IE. Effects of UVR and UVR-induced Cytokines on Production of Extracellular Matrix Proteins and Proteases by Dermal Fibroblasts Cultured in Collagen Gels Photochemistry and Photobiology. 79: 86-93. PMID 14974720 DOI: 10.1562/0031-8655(2004)79<86:EOUAUC>2.0.CO;2  1
2002 Sterner DE, Wang X, Bloom MH, Simon GM, Berger SL. The SANT domain of Ada2 is required for normal acetylation of histones by the yeast SAGA complex. The Journal of Biological Chemistry. 277: 8178-86. PMID 11777910 DOI: 10.1074/Jbc.M108601200  1
2000 Zhuang S, Simon G. Peroxynitrite-induced apoptosis involves activation of multiple caspases in HL-60 cells American Journal of Physiology - Cell Physiology. 279: C341-C351. PMID 10913000  1
1997 Przybylski M, Simon G. Short pulse excimer laser performances and its applications: I. Ophthamology Proceedings of Spie - the International Society For Optical Engineering. 2971: 90-95. DOI: 10.1117/12.275097  1
1996 Simon G, Arrayas I, Restrepo OL. Gel Injection Adjustable Keratoplasty (GIAK) in the treatment of Astigmatism Investigative Ophthalmology and Visual Science. 37: S67. DOI: 10.1007/BF00166303  1
1996 Arrayas I, Arrayas J, Restrepo OL, Simon G. Biomechanical behavior of the cornea and its response to posterior radial keratotomy Investigative Ophthalmology and Visual Science. 37: S321.  1
1996 Arrayas J, Segovia B, Restrepo OL, Vivar A, Simon G. "Lateral Island"?: A hazard on specific scanning delivery systems Investigative Ophthalmology and Visual Science. 37: S574.  1
1996 Vivar A, Lowery J, Restrepo OL, Simon G. A one year follow-up clinical results following Gonioscopic Laser Trabecular Ablation (GLTA) with a Ti:Sapphire laser for the treatment of glaucoma Investigative Ophthalmology and Visual Science. 37: S263.  1
1994 Ren Q, Simon G, Legeais JM, Parel JM, Culbertson W, Shen J, Takesue Y, Savoldelli M. Ultraviolet solid-state laser (213-nm) photorefractive keratectomy: In vivo study Ophthalmology. 101: 883-889. PMID 8190475  1
1994 Kuhne F, Simon G, Parel JM, Villain F, Hostyn P, Takesue Y. The results of a two year animal experimentation with polyethylene oxide intrastromal rings | LES RESULTATS DE 2 ANS D'EXPERIMENTATION ANIMALE DES ANNEAUX INTRASTROMAUX EN POLYOXYDE D'ETHYLENE RETICULE Journal Francais D'Ophtalmologie. 17: 83-92. PMID 8176189  1
1994 Ren Q, Simon G, Parel JM. Noncontact laser photothermal keratoplasty III: Histological study in animal eyes Journal of Refractive and Corneal Surgery. 10: 529-539. PMID 7530102  1
1994 Simon G, Ren Q, Parel JM. Noncontact laser photothermal keratoplasty II: Refractive effects and treatment parameters in cadaver eyes Journal of Refractive and Corneal Surgery. 10: 519-528. PMID 7530101  1
1994 Parel JM, Ren Q, Simon G. Noncontact laser photothermal keratoplasty I: Biophysical principles and laser beam delivery system Journal of Refractive and Corneal Surgery. 10: 511-518. PMID 7530100  1
1994 Simon G, Ren Q, Maloney RK, Feldman ST, Buzard K. Biomechanical behavior of the cornea and its response to radial keratotomy Journal of Refractive and Corneal Surgery. 10: 343-356. PMID 7522092  1
1993 Ren Q, Simon G, Parel JM, Smiddy W. Laser scleral buckling for retinal reattachment American Journal of Ophthalmology. 115: 758-762. PMID 8506911 DOI: 10.1016/S0002-9394(14)73644-X  1
1993 Simon G, Small RH, Ren Q, Parel JM. Effect of corneal hydration on Goldmann applanation tonometry and corneal topography Refractive and Corneal Surgery. 9: 110-117. PMID 8494810  1
1993 Simon G, Legeais JM, Parel JM. Optical power of the corneal epithelium | POUVOIR OPTIQUE DE L'EPITHELIUM CORNEEN Journal Francais D'Ophtalmologie. 16: 41-47. PMID 8482799  1
1993 Simon G, Ren Q, Kervick GN, Parel JM. Optics of the corneal epithelium Refractive and Corneal Surgery. 9: 42-50. PMID 8481372  1
1993 Legeais JM, Parel JM, Simon G, Ren Q, Denham D. Endothelial damage by the corneal Hessburg-Barron vacuum trephine Refractive and Corneal Surgery. 9: 255-258. PMID 8398970  1
1993 Hanna KD, Hayward JM, Hagen KB, Simon G, Parel JM, Waring GO. Keratotomy for astigmatism using an arcuate keratome Archives of Ophthalmology. 111: 998-1004. PMID 8328944  1
1993 Ren Q, Simon G, Parel JM. Ultraviolet solid-state laser (213-nm) photorefractive keratectomy: In vitro study Ophthalmology. 100: 1828-1834. PMID 8259282 DOI: 10.1016/S0161-6420(93)31390-4  1
1993 Legeais JM, Ren Q, Simon G, Parel JM. Computer-assisted corneal topography: Accuracy and reproducibility of the topographic modeling system Refractive and Corneal Surgery. 9: 347-357. PMID 8241039  1
1993 Simon G, Legeais JM, Parel JM. Radial keratotomy: Effect of wound hydration and intraocular pressure | KERATOTOMIE RADIAIRE, HYDRATATION CORNEENNE ET PRESSION INTRAOCULAIRE. ETUDE EXPERIMENTALE Journal Francais D'Ophtalmologie. 16: 657-662. PMID 8176160  1
1993 Villain F, Parel JM, Yonemura K, Simon G. Crosslinked polymers for correction of myopia Polymeric Materials Science and Engineering, Proceedings of the Acs Division of Polymeric Materials Science and Engineering. 69: 537-538.  1
1991 Simon G, Parel JM, Nose I, Lee W. Modification, calibration, and comparative testing of an automated surgical keratometer Refractive and Corneal Surgery. 7: 151-160. PMID 2043560  1
1991 Lingua RW, Parel JM, Simon G, Li K. Photodynamic treatment of lens epithelial cells for cataract surgery Proceedings of Spie - the International Society For Optical Engineering. 1423: 58-61.  1
1991 Simon G, Parel JM, Kervick G, Rol P, Hanna K, Thompson K. Corneal epithelium, visual acuity and laser refractive keratectomy Proceedings of Spie - the International Society For Optical Engineering. 1423: 154-156.  1
1991 Cartlidge AG, Parel JM, Yokokura T, Lowery JA, Kobayashi K, Nose I, Lee W, Simon G, Denham DB. Laser surgical unit for photoablative and photothermal keratoplasty Proceedings of Spie - the International Society For Optical Engineering. 1423: 167-174.  1
1990 Lowery JA, Parel JM, Roussel TJ, Simon G, Lee W, Nose I. Artificial orbit system for experimental surgery with enucleated globes Ophthalmic Surgery. 21: 522-528. PMID 2399003  1
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