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Alexandra M. Nicholson, Ph.D. - Publications

Affiliations: 
2010 Integrated Graduate Program in the Life Sciences Northwestern University, Evanston, IL 
Area:
Cell Biology, Molecular Neuroscience, Neurobiology of Disease
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27 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2020 Zhou X, Nicholson AM, Ren Y, Brooks M, Jiang P, Zuberi A, Phuoc HN, Perkerson RB, Matchett B, Parsons TM, Finch NA, Lin W, Qiao W, Castanedes-Casey M, Phillips V, et al. Loss of TMEM106B leads to myelination deficits: implications for frontotemporal dementia treatment strategies. Brain : a Journal of Neurology. PMID 32504082 DOI: 10.1093/Brain/Awaa141  0.355
2018 Arrant AE, Nicholson AM, Zhou X, Rademakers R, Roberson ED. Partial Tmem106b reduction does not correct abnormalities due to progranulin haploinsufficiency. Molecular Neurodegeneration. 13: 32. PMID 29929528 DOI: 10.1186/S13024-018-0264-6  0.453
2018 Nicholson AM, Zhou X, Perkerson RB, Parsons TM, Chew J, Brooks M, DeJesus-Hernandez M, Finch NA, Matchett BJ, Kurti A, Jansen-West KR, Perkerson E, Daughrity L, Castanedes-Casey M, Rousseau L, et al. Loss of Tmem106b is unable to ameliorate frontotemporal dementia-like phenotypes in an AAV mouse model of C9ORF72-repeat induced toxicity. Acta Neuropathologica Communications. 6: 42. PMID 29855382 DOI: 10.1186/S40478-018-0545-X  0.37
2017 Hirsch-Reinshagen V, Pottier C, Nicholson AM, Baker M, Hsiung GR, Krieger C, Sengdy P, Boylan KB, Dickson DW, Mesulam M, Weintraub S, Bigio E, Zinman L, Keith J, Rogaeva E, et al. Clinical and neuropathological features of ALS/FTD with TIA1 mutations. Acta Neuropathologica Communications. 5: 96. PMID 29216908 DOI: 10.1017/Cjn.2018.48  0.397
2017 Mackenzie IR, Nicholson AM, Sarkar M, Messing J, Purice MD, Pottier C, Annu K, Baker M, Perkerson RB, Kurti A, Matchett BJ, Mittag T, Temirov J, Hsiung GR, Krieger C, et al. TIA1 Mutations in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia Promote Phase Separation and Alter Stress Granule Dynamics. Neuron. 95: 808-816.e9. PMID 28817800 DOI: 10.1016/J.Neuron.2017.07.025  0.396
2016 Molgaard S, Demontis D, Nicholson AM, Finch NA, Petersen RC, Petersen CM, Rademakers R, Nykjaer A, Glerup S. Soluble sortilin is present in excess and positively correlates with progranulin in CSF of aging individuals. Experimental Gerontology. PMID 27612602 DOI: 10.1016/J.Exger.2016.09.002  0.345
2016 Nicholson AM, Rademakers R. What we know about TMEM106B in neurodegeneration. Acta Neuropathologica. PMID 27543298 DOI: 10.1007/S00401-016-1610-9  0.436
2016 Nicholson AM, Finch NA, Almeida M, Perkerson RB, van Blitterswijk M, Wojtas A, Cenik B, Rotondo S, Inskeep V, Almasy L, Dyer T, Peralta J, Jun G, Wood AR, Frayling TM, et al. Prosaposin is a regulator of progranulin levels and oligomerization. Nature Communications. 7: 11992. PMID 27356620 DOI: 10.1038/Ncomms11992  0.426
2015 Dickson DW, Rademakers R, Nicholson AM, Schneider JA, Yu L, Bennett DA. The TMEM106B locus and TDP-43 pathology in older persons without FTLD. Neurology. 85: 1354-5. PMID 26459943 DOI: 10.1212/01.Wnl.0000472918.79256.A9  0.397
2015 Pottier C, Bieniek KF, Finch N, van de Vorst M, Baker M, Perkersen R, Brown P, Ravenscroft T, van Blitterswijk M, Nicholson AM, DeTure M, Knopman DS, Josephs KA, Parisi JE, Petersen RC, et al. Whole-genome sequencing reveals important role for TBK1 and OPTN mutations in frontotemporal lobar degeneration without motor neuron disease. Acta Neuropathologica. 130: 77-92. PMID 25943890 DOI: 10.1007/S00401-015-1436-X  0.459
2014 Sanchez-Contreras M, Baker MC, Finch NA, Nicholson A, Wojtas A, Wszolek ZK, Ross OA, Dickson DW, Rademakers R. Genetic screening and functional characterization of PDGFRB mutations associated with basal ganglia calcification of unknown etiology. Human Mutation. 35: 964-71. PMID 24796542 DOI: 10.1002/Humu.22582  0.394
2014 van Blitterswijk M, Mullen B, Nicholson AM, Bieniek KF, Heckman MG, Baker MC, DeJesus-Hernandez M, Finch NA, Brown PH, Murray ME, Hsiung GY, Stewart H, Karydas AM, Finger E, Kertesz A, et al. TMEM106B protects C9ORF72 expansion carriers against frontotemporal dementia. Acta Neuropathologica. 127: 397-406. PMID 24385136 DOI: 10.1007/S00401-013-1240-4  0.402
2013 Sundal C, Fujioka S, Van Gerpen JA, Wider C, Nicholson AM, Baker M, Shuster EA, Aasly J, Spina S, Ghetti B, Roeber S, Garbern J, Tselis A, Swerdlow RH, Miller BB, et al. Parkinsonian features in hereditary diffuse leukoencephalopathy with spheroids (HDLS) and CSF1R mutations. Parkinsonism & Related Disorders. 19: 869-77. PMID 23787135 DOI: 10.1016/J.Parkreldis.2013.05.013  0.361
2013 Nicholson AM, Finch NA, Wojtas A, Baker MC, Perkerson RB, Castanedes-Casey M, Rousseau L, Benussi L, Binetti G, Ghidoni R, Hsiung GY, Mackenzie IR, Finger E, Boeve BF, Ertekin-Taner N, et al. TMEM106B p.T185S regulates TMEM106B protein levels: implications for frontotemporal dementia. Journal of Neurochemistry. 126: 781-91. PMID 23742080 DOI: 10.1111/Jnc.12329  0.404
2013 Nicholson AM, Baker MC, Finch NA, Rutherford NJ, Wider C, Graff-Radford NR, Nelson PT, Clark HB, Wszolek ZK, Dickson DW, Knopman DS, Rademakers R. CSF1R mutations link POLD and HDLS as a single disease entity. Neurology. 80: 1033-40. PMID 23408870 DOI: 10.1212/Wnl.0B013E31828726A7  0.408
2012 Sundal C, Van Gerpen JA, Nicholson AM, Wider C, Shuster EA, Aasly J, Spina S, Ghetti B, Roeber S, Garbern J, Borjesson-Hanson A, Tselis A, Swerdlow RH, Miller BB, Fujioka S, et al. MRI characteristics and scoring in HDLS due to CSF1R gene mutations. Neurology. 79: 566-74. PMID 22843259 DOI: 10.1212/Wnl.0B013E318263575A  0.342
2012 Nicholson AM, Gass J, Petrucelli L, Rademakers R. Progranulin axis and recent developments in frontotemporal lobar degeneration. Alzheimer's Research & Therapy. 4: 4. PMID 22277331 DOI: 10.1186/Alzrt102  0.418
2012 Rademakers R, Baker M, Nicholson AM, Rutherford NJ, Finch N, Soto-Ortolaza A, Lash J, Wider C, Wojtas A, DeJesus-Hernandez M, Adamson J, Kouri N, Sundal C, Shuster EA, Aasly J, et al. Mutations in the colony stimulating factor 1 receptor (CSF1R) gene cause hereditary diffuse leukoencephalopathy with spheroids. Nature Genetics. 44: 200-5. PMID 22197934 DOI: 10.1038/Ng.1027  0.381
2012 Nicholson AM, Wold LA, Walsh DM, Ferreira A. β-Amyloid carrying the Dutch mutation has diverse effects on calpain-mediated toxicity in hippocampal neurons. Molecular Medicine (Cambridge, Mass.). 18: 178-85. PMID 22160219 DOI: 10.2119/Molmed.2011.00366  0.623
2011 DeJesus-Hernandez M, Mackenzie IR, Boeve BF, Boxer AL, Baker M, Rutherford NJ, Nicholson AM, Finch NA, Flynn H, Adamson J, Kouri N, Wojtas A, Sengdy P, Hsiung GY, Karydas A, et al. Expanded GGGGCC hexanucleotide repeat in noncoding region of C9ORF72 causes chromosome 9p-linked FTD and ALS. Neuron. 72: 245-56. PMID 21944778 DOI: 10.1016/J.Neuron.2011.09.011  0.338
2011 Nicholson AM, Finch NA, Rademakers R. Human genetics as a tool to identify progranulin regulators. Journal of Molecular Neuroscience : Mn. 45: 532-7. PMID 21626010 DOI: 10.1007/S12031-011-9554-Y  0.392
2011 Nicholson AM, Methner DN, Ferreira A. Membrane cholesterol modulates {beta}-amyloid-dependent tau cleavage by inducing changes in the membrane content and localization of N-methyl-D-aspartic acid receptors. The Journal of Biological Chemistry. 286: 976-86. PMID 21047784 DOI: 10.1074/Jbc.M110.154138  0.563
2011 Ferreira A, Sinjoanu RC, Nicholson A, Kleinschmidt S. Aβ toxicity in primary cultured neurons. Methods in Molecular Biology (Clifton, N.J.). 670: 141-53. PMID 20967589 DOI: 10.1007/978-1-60761-744-0_11  0.565
2010 Nicholson AM, Ferreira A. CHOLESTEROL AND NEURONAL SUSCEPTIBILITY TO BETA-AMYLOID TOXICITY. Cognitive Sciences. 5: 35-56. PMID 25339981  0.556
2010 Carrasquillo MM, Nicholson AM, Finch N, Gibbs JR, Baker M, Rutherford NJ, Hunter TA, DeJesus-Hernandez M, Bisceglio GD, Mackenzie IR, Singleton A, Cookson MR, Crook JE, Dillman A, Hernandez D, et al. Genome-wide screen identifies rs646776 near sortilin as a regulator of progranulin levels in human plasma. American Journal of Human Genetics. 87: 890-7. PMID 21087763 DOI: 10.1016/J.Ajhg.2010.11.002  0.351
2009 Nicholson AM, Ferreira A. Increased membrane cholesterol might render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 29: 4640-51. PMID 19357288 DOI: 10.1523/Jneurosci.0862-09.2009  0.598
2008 Nicholson AM, Ferreira A. P3-341: Increased membrane cholesterol may render mature hippocampal neurons more susceptible to beta-amyloid-induced calpain activation and tau toxicity Alzheimer's & Dementia. 4: T621-T621. DOI: 10.1016/J.Jalz.2008.05.1910  0.566
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