| Year |
Citation |
Score |
| 2024 |
Pollalis D, Georgescu C, Wren JD, Tombulyan G, Leung JM, Lo PA, Bloemhof CM, Lee RH, Bae E, Bailey JK, Pennington BO, Khan AI, Kelly KR, Yeh AK, Sundaram KS, ... ... Clegg DO, et al. Rescuing Photoreceptors in RPE Dysfunction-Driven Retinal Degeneration: The Role of Small Extracellular Vesicles Secreted from Retinal Pigment Epithelium. Biorxiv : the Preprint Server For Biology. PMID 38645051 DOI: 10.1101/2024.04.09.588773 |
0.418 |
|
| 2024 |
Leung J, Pollalis D, Nair GKG, Bailey JK, Pennington BO, Khan AI, Kelly KR, Yeh AK, Sundaram KS, Clegg DO, Peng CC, Xu L, Lee SY. Isolation and Characterization of Extracellular Vesicles Through Orthogonal Approaches for the Development of Intraocular EV Therapy. Investigative Ophthalmology & Visual Science. 65: 6. PMID 38466285 DOI: 10.1167/iovs.65.3.6 |
0.759 |
|
| 2023 |
Fortress AM, Miyagishima KJ, Reed AA, Temple S, Clegg DO, Tucker BA, Blenkinsop TA, Harb G, Greenwell TN, Ludwig TE, Bharti K. Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report. Stem Cell Research & Therapy. 14: 53. PMID 36978104 DOI: 10.1186/s13287-023-03282-y |
0.358 |
|
| 2022 |
Zhang T, Huang X, Liu S, Bai X, Zhu X, Clegg DO, Jiang M, Sun X. Determining the optimal stage for cryopreservation of human embryonic stem cell-derived retinal pigment epithelial cells. Stem Cell Research & Therapy. 13: 454. PMID 36064625 DOI: 10.1186/s13287-022-03141-2 |
0.426 |
|
| 2022 |
Faynus MA, Bailey JK, Pennington BO, Katsura M, Proctor DA, Yeh AK, Menon S, Choi DG, Lebkowski JS, Johnson LV, Clegg DO. Microcarrier-Based Culture of Human Pluripotent Stem-Cell-Derived Retinal Pigmented Epithelium. Bioengineering (Basel, Switzerland). 9. PMID 35877348 DOI: 10.3390/bioengineering9070297 |
0.799 |
|
| 2021 |
Pennington BO, Bailey JK, Faynus MA, Hinman C, Hee MN, Ritts R, Nadar V, Zhu D, Mitra D, Martinez-Camarillo JC, Lin TC, Thomas BB, Hinton DR, Humayun MS, Lebkowski J, ... ... Clegg DO, et al. Xeno-free cryopreservation of adherent retinal pigmented epithelium yields viable and functional cells in vitro and in vivo. Scientific Reports. 11: 6286. PMID 33737600 DOI: 10.1038/s41598-021-85631-6 |
0.379 |
|
| 2019 |
Kashani AH, Martynova A, Koss M, Brant R, Zhu DH, Lebkowski J, Hinton D, Clegg D, Humayun MS. Subretinal Implantation of a Human Embryonic Stem Cell-Derived Retinal Pigment Epithelium Monolayer in a Porcine Model. Advances in Experimental Medicine and Biology. 1185: 569-574. PMID 31884672 DOI: 10.1007/978-3-030-27378-1_93 |
0.363 |
|
| 2019 |
Kashani AH, Uang J, Mert M, Rahhal F, Chan C, Avery RL, Dugel P, Chen S, Lebkowski J, Clegg DO, Hinton DR, Humayun MS. Surgical Method for Implantation of a Biosynthetic Retinal Pigment Epithelium Monolayer for Geographic Atrophy: Experience from a Phase 1/2a Study. Ophthalmology. Retina. PMID 31786135 DOI: 10.1016/J.Oret.2019.09.017 |
0.315 |
|
| 2018 |
Foltz LP, Howden SE, Thomson JA, Clegg DO. Functional Assessment of Patient-Derived Retinal Pigment Epithelial Cells Edited by CRISPR/Cas9. International Journal of Molecular Sciences. 19. PMID 30572641 DOI: 10.3390/Ijms19124127 |
0.397 |
|
| 2018 |
Foltz LP, Clegg DO. Patient-derived induced pluripotent stem cells for modelling genetic retinal dystrophies. Progress in Retinal and Eye Research. PMID 30217765 DOI: 10.1016/j.preteyeres.2018.09.002 |
0.396 |
|
| 2018 |
Kashani AH, Lebkowski JS, Rahhal FM, Avery RL, Salehi-Had H, Dang W, Lin CM, Mitra D, Zhu D, Thomas BB, Hikita ST, Pennington BO, Johnson LV, Clegg DO, Hinton DR, et al. A bioengineered retinal pigment epithelial monolayer for advanced, dry age-related macular degeneration. Science Translational Medicine. 10. PMID 29618560 DOI: 10.1126/Scitranslmed.Aao4097 |
0.758 |
|
| 2017 |
Foltz LP, Clegg DO. Rapid, Directed Differentiation of Retinal Pigment Epithelial Cells from Human Embryonic or Induced Pluripotent Stem Cells. Journal of Visualized Experiments : Jove. PMID 29155780 DOI: 10.3791/56274 |
0.378 |
|
| 2017 |
Lin TC, Seiler MJ, Zhu D, Falabella P, Hinton DR, Clegg DO, Humayun MS, Thomas BB. Assessment of Safety and Functional Efficacy of Stem Cell-Based Therapeutic Approaches Using Retinal Degenerative Animal Models. Stem Cells International. 2017: 9428176. PMID 28928775 DOI: 10.1155/2017/9428176 |
0.363 |
|
| 2016 |
Croze RH, Thi WJ, Clegg DO. ROCK Inhibition Promotes Attachment, Proliferation, and Wound Closure in Human Embryonic Stem Cell-Derived Retinal Pigmented Epithelium. Translational Vision Science & Technology. 5: 7. PMID 27917311 DOI: 10.1167/tvst.5.6.7 |
0.421 |
|
| 2016 |
Clevenger TN, Luna G, Boctor D, Fisher SK, Clegg DO. Cell-mediated remodeling of biomimetic encapsulating hydrogels triggered by adipogenic differentiation of adipose stem cells. Journal of Tissue Engineering. 7: 2041731416670482. PMID 27733898 DOI: 10.1177/2041731416670482 |
0.311 |
|
| 2016 |
Koss MJ, Falabella P, Stefanini FR, Pfister M, Thomas BB, Kashani AH, Brant R, Zhu D, Clegg DO, Hinton DR, Humayun MS. Subretinal implantation of a monolayer of human embryonic stem cell-derived retinal pigment epithelium: a feasibility and safety study in Yucatán minipigs. Graefe's Archive For Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Fur Klinische Und Experimentelle Ophthalmologie. PMID 27335025 DOI: 10.1007/S00417-016-3386-Y |
0.331 |
|
| 2016 |
Thomas BB, Zhu D, Zhang L, Thomas PB, Hu Y, Nazari H, Stefanini F, Falabella P, Clegg DO, Hinton DR, Humayun MS. Survival and Functionality of hESC-Derived Retinal Pigment Epithelium Cells Cultured as a Monolayer on Polymer Substrates Transplanted in RCS Rats. Investigative Ophthalmology & Visual Science. 57: 2877-2887. PMID 27233037 DOI: 10.1167/Iovs.16-19238 |
0.31 |
|
| 2016 |
Leach LL, Croze RH, Hu Q, Nadar VP, Clevenger TN, Pennington BO, Gamm DM, Clegg DO. Induced Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium: A Comparative Study Between Cell Lines and Differentiation Methods. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. PMID 27182743 DOI: 10.1089/jop.2016.0022 |
0.384 |
|
| 2016 |
Pennington BO, Clegg DO. Pluripotent Stem Cell-Based Therapies in Combination with Substrate for the Treatment of Age-Related Macular Degeneration. Journal of Ocular Pharmacology and Therapeutics : the Official Journal of the Association For Ocular Pharmacology and Therapeutics. PMID 26889704 DOI: 10.1089/jop.2015.0153 |
0.384 |
|
| 2016 |
Lopez P, Aguilar T, Wu R, Krishnan A, Kong D, Patel J, Javier H, Dang W, Wong D, Zhu D, Dodd J, Shad Y, Humayun M, Hinton D, Clegg D, et al. 445. cGMP Compliant Production for Human Embryonic Stem Cell Derived Retinal Pigment Epithelial Cells on a Synthetic Substrate for the Treatment of Non-Neovascular Age-Related Macular Degeneration for Phase I Clinical Study Molecular Therapy. 24: S176. DOI: 10.1016/S1525-0016(16)33254-3 |
0.367 |
|
| 2015 |
Zhao T, Zhang ZN, Westenskow PD, Todorova D, Hu Z, Lin T, Rong Z, Kim J, He J, Wang M, Clegg DO, Yang YG, Zhang K, Friedlander M, Xu Y. Humanized Mice Reveal Differential Immunogenicity of Cells Derived from Autologous Induced Pluripotent Stem Cells. Cell Stem Cell. 17: 353-9. PMID 26299572 DOI: 10.1016/J.Stem.2015.07.021 |
0.362 |
|
| 2015 |
Nazari H, Zhang L, Zhu D, Chader GJ, Falabella P, Stefanini F, Rawland T, Clegg DO, Kashani AH, Hinton DR, Humayun MS. Stem cell based therapies for age-related macular degeneration: the promises and the challenges. Progress in Retinal and Eye Research. PMID 26113213 DOI: 10.1016/J.Preteyeres.2015.06.004 |
0.392 |
|
| 2015 |
Forest DL, Johnson LV, Clegg DO. Cellular models and therapies for age-related macular degeneration. Disease Models & Mechanisms. 8: 421-7. PMID 26035859 DOI: 10.1242/Dmm.017236 |
0.364 |
|
| 2015 |
Leach LL, Clegg DO. Concise Review: Making Stem Cells Retinal: Methods for Deriving Retinal Pigment Epithelium and Implications for Patients With Ocular Disease. Stem Cells (Dayton, Ohio). 33: 2363-73. PMID 25809736 DOI: 10.1002/stem.2010 |
0.407 |
|
| 2015 |
Leach LL, Buchholz DE, Nadar VP, Lowenstein SE, Clegg DO. Canonical/β-catenin Wnt pathway activation improves retinal pigmented epithelium derivation from human embryonic stem cells. Investigative Ophthalmology & Visual Science. 56: 1002-13. PMID 25604686 DOI: 10.1167/iovs.14-15835 |
0.318 |
|
| 2015 |
Pennington BO, Clegg DO, Melkoumian ZK, Hikita ST. Defined culture of human embryonic stem cells and xeno-free derivation of retinal pigmented epithelial cells on a novel, synthetic substrate. Stem Cells Translational Medicine. 4: 165-77. PMID 25593208 DOI: 10.5966/Sctm.2014-0179 |
0.785 |
|
| 2014 |
Hu Q, Chen R, Teesalu T, Ruoslahti E, Clegg DO. Reprogramming human retinal pigmented epithelial cells to neurons using recombinant proteins. Stem Cells Translational Medicine. 3: 1526-34. PMID 25298373 DOI: 10.5966/Sctm.2014-0038 |
0.378 |
|
| 2014 |
Croze RH, Buchholz DE, Radeke MJ, Thi WJ, Hu Q, Coffey PJ, Clegg DO. ROCK Inhibition Extends Passage of Pluripotent Stem Cell-Derived Retinal Pigmented Epithelium. Stem Cells Translational Medicine. 3: 1066-78. PMID 25069775 DOI: 10.5966/sctm.2014-0079 |
0.393 |
|
| 2014 |
Croze RH, Clegg DO. Differentiation of pluripotent stem cells into retinal pigmented epithelium. Developments in Ophthalmology. 53: 81-96. PMID 24732763 DOI: 10.1159/000357361 |
0.365 |
|
| 2014 |
Clegg D. Stem cell strategies for retinal disease Journal of Vision. 14: 3-3. DOI: 10.1167/14.15.3 |
0.458 |
|
| 2013 |
Buchholz DE, Pennington BO, Croze RH, Hinman CR, Coffey PJ, Clegg DO. Rapid and efficient directed differentiation of human pluripotent stem cells into retinal pigmented epithelium. Stem Cells Translational Medicine. 2: 384-93. PMID 23599499 DOI: 10.5966/sctm.2012-0163 |
0.39 |
|
| 2013 |
Rowland TJ, Blaschke AJ, Buchholz DE, Hikita ST, Johnson LV, Clegg DO. Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins. Journal of Tissue Engineering and Regenerative Medicine. 7: 642-53. PMID 22514096 DOI: 10.1002/Term.1458 |
0.82 |
|
| 2012 |
Hu Y, Liu L, Lu B, Zhu D, Ribeiro R, Diniz B, Thomas PB, Ahuja AK, Hinton DR, Tai YC, Hikita ST, Johnson LV, Clegg DO, Thomas BB, Humayun MS. A novel approach for subretinal implantation of ultrathin substrates containing stem cell-derived retinal pigment epithelium monolayer. Ophthalmic Research. 48: 186-91. PMID 22868580 DOI: 10.1159/000338749 |
0.772 |
|
| 2012 |
Rowland TJ, Buchholz DE, Clegg DO. Pluripotent human stem cells for the treatment of retinal disease. Journal of Cellular Physiology. 227: 457-66. PMID 21520078 DOI: 10.1002/Jcp.22814 |
0.707 |
|
| 2010 |
Gupta N, Lin BF, Campos LM, Dimitriou MD, Hikita ST, Treat ND, Tirrell MV, Clegg DO, Kramer EJ, Hawker CJ. A versatile approach to high-throughput microarrays using thiol-ene chemistry. Nature Chemistry. 2: 138-45. PMID 21124405 DOI: 10.1038/Nchem.1328 |
0.721 |
|
| 2010 |
Hu Q, Friedrich AM, Johnson LV, Clegg DO. Memory in induced pluripotent stem cells: reprogrammed human retinal-pigmented epithelial cells show tendency for spontaneous redifferentiation. Stem Cells (Dayton, Ohio). 28: 1981-91. PMID 20882530 DOI: 10.1002/Stem.531 |
0.374 |
|
| 2010 |
Kolhar P, Kotamraju VR, Hikita ST, Clegg DO, Ruoslahti E. Synthetic surfaces for human embryonic stem cell culture. Journal of Biotechnology. 146: 143-6. PMID 20132848 DOI: 10.1016/J.Jbiotec.2010.01.016 |
0.764 |
|
| 2010 |
Rowland TJ, Miller LM, Blaschke AJ, Doss EL, Bonham AJ, Hikita ST, Johnson LV, Clegg DO. Roles of integrins in human induced pluripotent stem cell growth on Matrigel and vitronectin. Stem Cells and Development. 19: 1231-40. PMID 19811096 DOI: 10.1089/Scd.2009.0328 |
0.823 |
|
| 2010 |
Buchholz DE, Hikita ST, Radeke MJ, Blashke KE, Johnson LV, Clegg DO. Stem cell derived retinal pigment Epithelium for the treatment of age-related Macular degeneration Journal of Vision. 8: 47-47. DOI: 10.1167/8.17.47 |
0.78 |
|
| 2009 |
Carr AJ, Vugler AA, Hikita ST, Lawrence JM, Gias C, Chen LL, Buchholz DE, Ahmado A, Semo M, Smart MJ, Hasan S, da Cruz L, Johnson LV, Clegg DO, Coffey PJ. Protective effects of human iPS-derived retinal pigment epithelium cell transplantation in the retinal dystrophic rat. Plos One. 4: e8152. PMID 19997644 DOI: 10.1371/Journal.Pone.0008152 |
0.812 |
|
| 2009 |
Buchholz DE, Hikita ST, Rowland TJ, Friedrich AM, Hinman CR, Johnson LV, Clegg DO. Derivation of functional retinal pigmented epithelium from induced pluripotent stem cells. Stem Cells (Dayton, Ohio). 27: 2427-34. PMID 19658190 DOI: 10.1002/Stem.189 |
0.827 |
|
| 2008 |
Hikita ST, Kosik KS, Clegg DO, Bamdad C. MUC1* mediates the growth of human pluripotent stem cells. Plos One. 3: e3312. PMID 18833326 DOI: 10.1371/Journal.Pone.0003312 |
0.763 |
|
| 2007 |
Dunkle ET, Zaucke F, Clegg DO. Thrombospondin-4 and matrix three-dimensionality in axon outgrowth and adhesion in the developing retina. Experimental Eye Research. 84: 707-17. PMID 17320079 DOI: 10.1016/J.Exer.2006.12.014 |
0.753 |
|
| 2006 |
Hikita ST, Vistica BP, Jones HR, Keswani JR, Watson MM, Ericson VR, Ayoub GS, Gery I, Clegg DO. Osteopontin is proinflammatory in experimental autoimmune uveitis. Investigative Ophthalmology & Visual Science. 47: 4435-43. PMID 17003437 DOI: 10.1167/Iovs.06-0064 |
0.749 |
|
| 2005 |
Wingerd KL, Wayne WC, Jackson DY, Clegg DO. Involvement of alpha4 integrins in maintenance of cardiac sympathetic axons. Autonomic Neuroscience : Basic & Clinical. 122: 58-68. PMID 16181811 DOI: 10.1016/J.Autneu.2005.08.006 |
0.792 |
|
| 2005 |
Putzke AP, Hikita ST, Clegg DO, Rothman JH. Essential kinase-independent role of a Fer-like non-receptor tyrosine kinase in Caenorhabditis elegans morphogenesis. Development (Cambridge, England). 132: 3185-95. PMID 15958510 DOI: 10.1242/Dev.01900 |
0.762 |
|
| 2004 |
Leu ST, Jacques SA, Wingerd KL, Hikita ST, Tolhurst EC, Pring JL, Wiswell D, Kinney L, Goodman NL, Jackson DY, Clegg DO. Integrin alpha4beta1 function is required for cell survival in developing retina. Developmental Biology. 276: 416-30. PMID 15581875 DOI: 10.1016/J.Ydbio.2004.09.003 |
0.815 |
|
| 2004 |
Wingerd KL, Goodman NL, Leu ST, Clegg DO. Expression and function of integrin alpha4beta1 and vascular cell adhesion molecule-1 (VCAM-1) during sympathetic innervation of the heart. Developmental Dynamics : An Official Publication of the American Association of Anatomists. 231: 359-69. PMID 15366013 DOI: 10.1002/Dvdy.20120 |
0.804 |
|
| 2003 |
Hikita ST, Cann GM, Wingerd KL, Mullick LH, Wayne WC, Webb SW, Clegg DO. Integrin alpha4beta1 (VLA-4) expression and activity in retinal and peripheral neurons. Molecular and Cellular Neurosciences. 23: 427-39. PMID 12837626 DOI: 10.1016/S1044-7431(03)00065-4 |
0.796 |
|
| 2003 |
Clegg DO, Wingerd KL, Hikita ST, Tolhurst EC. Integrins in the development, function and dysfunction of the nervous system. Frontiers in Bioscience : a Journal and Virtual Library. 8: d723-50. PMID 12700040 DOI: 10.2741/1020 |
0.798 |
|
| 2002 |
Wingerd KL, Goodman NL, Tresser JW, Smail MM, Leu ST, Rohan SJ, Pring JL, Jackson DY, Clegg DO. Alpha 4 integrins and vascular cell adhesion molecule-1 play a role in sympathetic innervation of the heart. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 22: 10772-80. PMID 12486170 |
0.791 |
|
| 2001 |
Leonoudakis D, Mailliard W, Wingerd K, Clegg D, Vandenberg C. Inward rectifier potassium channel Kir2.2 is associated with synapse-associated protein SAP97. Journal of Cell Science. 114: 987-98. PMID 11181181 |
0.759 |
|
| 2000 |
Clegg DO, Mullick LH, Wingerd KL, Lin H, Atienza JW, Bradshaw AD, Gervin DB, Cann GM. Adhesive events in retinal development and function: the role of integrin receptors. Results and Problems in Cell Differentiation. 31: 141-56. PMID 10929405 DOI: 10.1007/978-3-540-46826-4_8 |
0.832 |
|
| 1998 |
Kil SH, Krull CE, Cann G, Clegg D, Bronner-Fraser M. The alpha4 subunit of integrin is important for neural crest cell migration. Developmental Biology. 202: 29-42. PMID 9758701 DOI: 10.1006/Dbio.1998.8985 |
0.421 |
|
| 1996 |
Cann GM, Bradshaw AD, Gervin DB, Hunter AW, Clegg DO. Widespread expression of beta1 integrins in the developing chick retina: evidence for a role in migration of retinal ganglion cells. Developmental Biology. 180: 82-96. PMID 8948576 DOI: 10.1006/Dbio.1996.0286 |
0.692 |
|
| 1996 |
Smith BE, Bradshaw AD, Choi ES, Rouselle P, Wayner EA, Clegg DO. Human SY5Y neuroblastoma cell interactions with laminin isoforms: neurite outgrowth on laminin-5 is mediated by integrin alpha 3 beta 1. Cell Adhesion and Communication. 3: 451-62. PMID 8807189 DOI: 10.3109/15419069609081022 |
0.649 |
|
| 1995 |
Setty S, Anderson SS, Wayner EA, Kim Y, Clegg DO, Tsilibary EC. Glucose-induced alteration of integrin expression and function in cultured human mesangial cells. Cell Adhesion and Communication. 3: 187-200. PMID 8846021 DOI: 10.3109/15419069509081286 |
0.328 |
|
| 1995 |
Bradshaw AD, McNagny KM, Gervin DB, Cann GM, Graf T, Clegg DO. Integrin alpha 2 beta 1 mediates interactions between developing embryonic retinal cells and collagen. Development (Cambridge, England). 121: 3593-602. PMID 8582273 |
0.456 |
|
| 1985 |
Clegg DO, Koshland DE. Identification of a bacterial sensing protein and effects of its elevated expression Journal of Bacteriology. 162: 398-405. PMID 2984180 DOI: 10.1128/Jb.162.1.398-405.1985 |
0.36 |
|
| 1984 |
Clegg DO, Koshland DE. The role of a signaling protein in bacterial sensing: Behavioral effects of increased gene expression Proceedings of the National Academy of Sciences of the United States of America. 81: 5056-5060. PMID 6089173 DOI: 10.1073/Pnas.81.16.5056 |
0.364 |
|
| 1982 |
Wang EA, Mowry KL, Clegg DO, Koshland DE. Tandem duplication and multiple functions of a receptor gene in bacterial chemotaxis. The Journal of Biological Chemistry. 257: 4673-6. PMID 6279644 |
0.347 |
|
| 1981 |
Wang JYJ, Clegg DO, Koshland DE. Molecular cloning and amplification of the adenylate cyclase gene Proceedings of the National Academy of Sciences of the United States of America. 78: 4684-4688. PMID 6272270 DOI: 10.1073/Pnas.78.8.4684 |
0.341 |
|
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