269 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2019 Kakoki M, Bahnson EM, Hagaman JR, Siletzky RM, Grant R, Kayashima Y, Li F, Lee EY, Sun MT, Taylor JM, Rice JC, Almeida MF, Bahr BA, Jennette JC, Smithies O, et al. Engulfment and cell motility protein 1 potentiates diabetic cardiomyopathy via Rac-dependent and Rac-independent ROS production. Jci Insight. 4. PMID 31217360 DOI: 10.1172/jci.insight.127660  0.64
2018 Govindapillai A, Hotchkiss A, Baguma-Nibasheka M, Rose RA, Miquerol L, Smithies O, Maeda N, Pasumarthi KBS. Characterizing the role of atrial natriuretic peptide signaling in the development of embryonic ventricular conduction system. Scientific Reports. 8: 6939. PMID 29720615 DOI: 10.1038/s41598-018-25292-0  0.96
2018 Li F, Kakoki M, Smid M, Boggess K, Wilder J, Hiller S, Bounajim C, Parnell SE, Sulik KK, Smithies O, Maeda-Smithies N. Causative Effects of Genetically Determined High Maternal/Fetal Endothelin-1 on Preeclampsia-Like Conditions in Mice. Hypertension (Dallas, Tex. : 1979). PMID 29610266 DOI: 10.1161/HYPERTENSIONAHA.117.10849  0.48
2017 Lawrence MG, Altenburg MK, Sanford R, Willett JD, Bleasdale B, Ballou B, Wilder J, Li F, Miner JH, Berg UB, Smithies O. Permeation of macromolecules into the renal glomerular basement membrane and capture by the tubules. Proceedings of the National Academy of Sciences of the United States of America. PMID 28246329 DOI: 10.1073/pnas.1616457114  0.48
2016 Li F, Fushima T, Oyanagi G, Townley-Tilson HW, Sato E, Nakada H, Oe Y, Hagaman JR, Wilder J, Li M, Sekimoto A, Saigusa D, Sato H, Ito S, Jennette JC, ... ... Smithies O, et al. Nicotinamide benefits both mothers and pups in two contrasting mouse models of preeclampsia. Proceedings of the National Academy of Sciences of the United States of America. PMID 27821757 DOI: 10.1073/pnas.1614947113  0.96
2016 Chang AS, Grant R, Tomita H, Kim HS, Smithies O, Kakoki M. Prolactin alters blood pressure by modulating the activity of endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. PMID 27791173 DOI: 10.1073/pnas.1615051113  0.48
2016 Lawrence M, Testen A, Koklic T, Smithies O. A Simple Method for the Size Controlled Synthesis of Stable Oligomeric Clusters of Gold Nanoparticles under Ambient Conditions. Journal of Visualized Experiments : Jove. PMID 26890032 DOI: 10.3791/53388  0.96
2016 Hathaway CK, Chang AS, Grant R, Kim HS, Madden VJ, Bagnell CR, Jennette JC, Smithies O, Kakoki M. High Elmo1 expression aggravates and low Elmo1 expression prevents diabetic nephropathy. Proceedings of the National Academy of Sciences of the United States of America. PMID 26858454 DOI: 10.1073/pnas.1600511113  0.96
2015 Chang AS, Hathaway CK, Smithies O, Kakoki M. Transforming growth factor β1 and diabetic nephropathy. American Journal of Physiology. Renal Physiology. ajprenal.00502.2015. PMID 26719364 DOI: 10.1152/ajprenal.00502.2015  0.96
2015 Hathaway CK, Gasim AM, Grant R, Chang AS, Kim HS, Madden VJ, Bagnell CR, Jennette JC, Smithies O, Kakoki M. Low TGFβ1 expression prevents and high expression exacerbates diabetic nephropathy in mice. Proceedings of the National Academy of Sciences of the United States of America. 112: 5815-20. PMID 25902541 DOI: 10.1073/pnas.1504777112  0.96
2015 Hathaway CK, Grant R, Hagaman JR, Hiller S, Li F, Xu L, Chang AS, Madden VJ, Bagnell CR, Rojas M, Kim HS, Wu B, Zhou B, Smithies O, Kakoki M. Endothelin-1 critically influences cardiac function via superoxide-MMP9 cascade. Proceedings of the National Academy of Sciences of the United States of America. 112: 5141-6. PMID 25848038 DOI: 10.1073/pnas.1504557112  0.96
2015 Smithies O, Coffman T. A conversation with Oliver Smithies. Annual Review of Physiology. 77: 1-11. PMID 25668016 DOI: 10.1146/annurev-physiol-021014-071806  0.96
2015 Matsuki K, Hathaway CK, Chang AS, Smithies O, Kakoki M. Transforming growth factor beta1 and aldosterone. Current Opinion in Nephrology and Hypertension. 24: 139-44. PMID 25587902 DOI: 10.1097/MNH.0000000000000100  0.96
2014 Matsuki K, Hathaway CK, Lawrence MG, Smithies O, Kakoki M. The role of transforming growth factor β1 in the regulation of blood pressure. Current Hypertension Reviews. 10: 223-38. PMID 25801626  0.96
2014 Smithies O, Lawrence M, Testen A, Horne LP, Wilder J, Altenburg M, Bleasdale B, Maeda N, Koklic T. Stable oligomeric clusters of gold nanoparticles: preparation, size distribution, derivatization, and physical and biological properties. Langmuir : the Acs Journal of Surfaces and Colloids. 30: 13394-404. PMID 25317930 DOI: 10.1021/la5032637  0.96
2014 Allred SC, Schreiner WJ, Smithies O. Colour blindness: still too many red-green figures. Nature. 510: 340. PMID 24943948 DOI: 10.1038/510340e  0.96
2013 Bai X, Lenhart KC, Bird KE, Suen AA, Rojas M, Kakoki M, Li F, Smithies O, Mack CP, Taylor JM. The smooth muscle-selective RhoGAP GRAF3 is a critical regulator of vascular tone and hypertension. Nature Communications. 4: 2910. PMID 24335996 DOI: 10.1038/ncomms3910  0.96
2013 Kakoki M, Pochynyuk OM, Hathaway CM, Tomita H, Hagaman JR, Kim HS, Zaika OL, Mamenko M, Kayashima Y, Matsuki K, Hiller S, Li F, Xu L, Grant R, Bertorello AM, ... Smithies O, et al. Primary aldosteronism and impaired natriuresis in mice underexpressing TGFβ1. Proceedings of the National Academy of Sciences of the United States of America. 110: 5600-5. PMID 23503843 DOI: 10.1073/pnas.1302641110  0.96
2012 Vashistha H, Singhal PC, Malhotra A, Husain M, Mathieson P, Saleem MA, Kuriakose C, Seshan S, Wilk A, Delvalle L, Peruzzi F, Giorgio M, Pelicci PG, Smithies O, Kim HS, et al. Null mutations at the p66 and bradykinin 2 receptor loci induce divergent phenotypes in the diabetic kidney. American Journal of Physiology. Renal Physiology. 303: F1629-40. PMID 23019230 DOI: 10.1152/ajprenal.00246.2012  0.96
2012 Pandya K, Kohro T, Mimura I, Kobayashi M, Wada Y, Kodama T, Smithies O. Distribution of histone3 lysine 4 trimethylation at T3-responsive loci in the heart during reversible changes in gene expression. Gene Expression. 15: 183-98. PMID 22783727 DOI: 10.3727/105221612X13372578119698  0.96
2012 Smithies O. How it all began: a personal history of gel electrophoresis. Methods in Molecular Biology (Clifton, N.J.). 869: 1-21. PMID 22585472 DOI: 10.1007/978-1-61779-821-4_1  0.96
2012 Tomita H, Sanford RB, Smithies O, Kakoki M. The kallikrein-kinin system in diabetic nephropathy. Kidney International. 81: 733-44. PMID 22318421 DOI: 10.1038/ki.2011.499  0.96
2012 Li F, Hagaman JR, Kim HS, Maeda N, Jennette JC, Faber JE, Karumanchi SA, Smithies O, Takahashi N. eNOS deficiency acts through endothelin to aggravate sFlt-1-induced pre-eclampsia-like phenotype. Journal of the American Society of Nephrology : Jasn. 23: 652-60. PMID 22282588 DOI: 10.1681/ASN.2011040369  0.96
2012 Zajac B, Hakim ZS, Cameron MV, Smithies O, Taylor JM. Quantification of myocyte chemotaxis: a role for FAK in regulating directional motility. Methods in Molecular Biology (Clifton, N.J.). 843: 111-23. PMID 22222526 DOI: 10.1007/978-1-61779-523-7_11  0.96
2012 Kayashima Y, Smithies O, Kakoki M. The kallikrein-kinin system and oxidative stress. Current Opinion in Nephrology and Hypertension. 21: 92-6. PMID 22048723 DOI: 10.1097/MNH.0b013e32834d54b1  0.96
2012 Reid LH, Smithies O. Gene Targeting and Electroporation Guide to Electroporation and Electrofusion. 209-225. DOI: 10.1016/B978-0-08-091727-6.50017-4  0.96
2012 Takahashi N, Li F, Wang CH, Mackman N, Maeda N, Smithies O, Jennette JC. Decreased eNOS and high fat diet in diabetic nephropathy Therapeutic Research. 33: 1206-1208.  0.96
2011 Pandya K, Smithies O. β-MyHC and cardiac hypertrophy: size does matter. Circulation Research. 109: 609-10. PMID 21885833 DOI: 10.1161/CIRCRESAHA.111.252619  0.96
2011 Fox R, Kim HS, Reddick RL, Kujoth GC, Prolla TA, Tsutsumi S, Wada Y, Smithies O, Maeda N. Mitochondrial DNA polymerase editing mutation, PolgD257A, reduces the diabetic phenotype of Akita male mice by suppressing appetite. Proceedings of the National Academy of Sciences of the United States of America. 108: 8779-84. PMID 21555558 DOI: 10.1073/pnas.1106344108  0.96
2011 Wang CH, Li F, Hiller S, Kim HS, Maeda N, Smithies O, Takahashi N. A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy. Proceedings of the National Academy of Sciences of the United States of America. 108: 2070-5. PMID 21245338 DOI: 10.1073/pnas.1018766108  0.96
2011 Hatada S, Walton W, Hatada T, Wofford A, Fox R, Liu N, Lill MC, Fair JH, Kirby SL, Smithies O. Therapeutic benefits in thalassemic mice transplanted with long-term-cultured bone marrow cells. Experimental Hematology. 39: 375-83, 383.e1-4. PMID 21184801 DOI: 10.1016/j.exphem.2010.12.007  0.96
2011 Kakoki M, Smithies O. Kallikrein-kinin system in diabetes Kinins. 273-287. DOI: 10.1515/9783110252354  0.96
2011 Wang CH, Li F, Hiller S, Kim HS, Maeda N, Smithies O, Takahashi N. A modest decrease in endothelial NOS in mice comparable to that associated with human NOS3 variants exacerbates diabetic nephropathy (Proceedings of the National Academy of Sciences of the United States of America (2011) 108, 5, (2070-2075) DOI:10.1073/pnas.1018766108) Proceedings of the National Academy of Sciences of the United States of America. 108: 3453. DOI: 10.1073/pnas.1101346108  0.96
2010 Pandya K, Pulli B, Bultman S, Smithies O. Reversible epigenetic modifications of the two cardiac myosin heavy chain genes during changes in expression. Gene Expression. 15: 51-9. PMID 21526716 DOI: 10.3727/105221611X12973615737505  0.96
2010 Smithies O. Science brick by brick. Nature. 467: S6. PMID 20944621 DOI: 10.1038/467S6a  0.96
2010 Konno T, Chen D, Wang L, Wakimoto H, Teekakirikul P, Nayor M, Kawana M, Eminaga S, Gorham JM, Pandya K, Smithies O, Naya FJ, Olson EN, Seidman JG, Seidman CE. Heterogeneous myocyte enhancer factor-2 (Mef2) activation in myocytes predicts focal scarring in hypertrophic cardiomyopathy. Proceedings of the National Academy of Sciences of the United States of America. 107: 18097-102. PMID 20923879 DOI: 10.1073/pnas.1012826107  0.96
2010 Messadi E, Vincent MP, Griol-Charhbili V, Mandet C, Colucci J, Krege JH, Bruneval P, Bouby N, Smithies O, Alhenc-Gelas F, Richer C. Genetically determined angiotensin converting enzyme level and myocardial tolerance to ischemia. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. 24: 4691-700. PMID 20667972 DOI: 10.1096/fj.10-165902  0.96
2010 Wende AR, Soto J, Olsen CD, Pires KM, Schell JC, Larrieu-Lahargue F, Litwin SE, Kakoki M, Takahashi N, Smithies O, Abel ED. Loss of bradykinin signaling does not accelerate the development of cardiac dysfunction in type 1 diabetic akita mice. Endocrinology. 151: 3536-42. PMID 20501666 DOI: 10.1210/en.2010-0256  0.96
2010 Kakoki M, Sullivan KA, Backus C, Hayes JM, Oh SS, Hua K, Gasim AM, Tomita H, Grant R, Nossov SB, Kim HS, Jennette JC, Feldman EL, Smithies O. Lack of both bradykinin B1 and B2 receptors enhances nephropathy, neuropathy, and bone mineral loss in Akita diabetic mice. Proceedings of the National Academy of Sciences of the United States of America. 107: 10190-5. PMID 20479236 DOI: 10.1073/pnas.1005144107  0.96
2010 Koller BH, Marrack P, Kappler JW, Smithies O. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. 1990. Journal of Immunology (Baltimore, Md. : 1950). 184: 4592-5. PMID 20410496  0.96
2010 Koller BH, Marrack P, Kappler JW, Smithies O. Normal development of mice deficient in β2M, MHC class I proteins, and CD8+ T cells Journal of Immunology. 184: 1227-1230. DOI: 10.1126/science.2112266  0.96
2009 Tsai YS, Xu L, Smithies O, Maeda N. Genetic variations in peroxisome proliferator-activated receptor gamma expression affect blood pressure. Proceedings of the National Academy of Sciences of the United States of America. 106: 19084-9. PMID 19884495 DOI: 10.1073/pnas.0909657106  0.96
2009 Scott NJ, Ellmers LJ, Lainchbury JG, Maeda N, Smithies O, Richards AM, Cameron VA. Influence of natriuretic peptide receptor-1 on survival and cardiac hypertrophy during development. Biochimica Et Biophysica Acta. 1792: 1175-84. PMID 19782130 DOI: 10.1016/j.bbadis.2009.09.009  0.96
2009 Brosius FC, Alpers CE, Bottinger EP, Breyer MD, Coffman TM, Gurley SB, Harris RC, Kakoki M, Kretzler M, Leiter EH, Levi M, McIndoe RA, Sharma K, Smithies O, Susztak K, et al. Mouse models of diabetic nephropathy. Journal of the American Society of Nephrology : Jasn. 20: 2503-12. PMID 19729434 DOI: 10.1681/ASN.2009070721  0.96
2009 Huby AC, Rastaldi MP, Caron K, Smithies O, Dussaule JC, Chatziantoniou C. Restoration of podocyte structure and improvement of chronic renal disease in transgenic mice overexpressing renin. Plos One. 4: e6721. PMID 19696925 DOI: 10.1371/journal.pone.0006721  0.96
2009 Pandya K, Porter K, Rockman HA, Smithies O. Decreased beta-adrenergic responsiveness following hypertrophy occurs only in cardiomyocytes that also re-express beta-myosin heavy chain. European Journal of Heart Failure. 11: 648-52. PMID 19553396 DOI: 10.1093/eurjhf/hfp073  0.96
2009 Epple-Farmer J, Debeb BG, Smithies O, Binas B. Gender-dependent survival of allogeneic trophoblast stem cells in liver. Cell Transplantation. 18: 769-76. PMID 19523327 DOI: 10.3727/096368909X470856  0.96
2009 Kakoki M, Smithies O. The kallikrein-kinin system in health and in diseases of the kidney. Kidney International. 75: 1019-30. PMID 19190676 DOI: 10.1038/ki.2008.647  0.96
2009 Svasti S, Suwanmanee T, Fucharoen S, Moulton HM, Nelson MH, Maeda N, Smithies O, Kole R. RNA repair restores hemoglobin expression in IVS2-654 thalassemic mice. Proceedings of the National Academy of Sciences of the United States of America. 106: 1205-10. PMID 19164558 DOI: 10.1073/pnas.0812436106  0.96
2008 Pandya K, Cowhig J, Brackhan J, Kim HS, Hagaman J, Rojas M, Carter CW, Mao L, Rockman HA, Maeda N, Smithies O. Discordant on/off switching of gene expression in myocytes during cardiac hypertrophy in vivo. Proceedings of the National Academy of Sciences of the United States of America. 105: 13063-8. PMID 18755891 DOI: 10.1073/pnas.0805120105  0.96
2008 Smithies O. Turning pages (Nobel lecture). Chembiochem : a European Journal of Chemical Biology. 9: 1342-59. PMID 18543237 DOI: 10.1002/cbic.200800205  0.96
2008 Brosnihan KB, Hodgin JB, Smithies O, Maeda N, Gallagher P. Tissue-specific regulation of ACE/ACE2 and AT1/AT2 receptor gene expression by oestrogen in apolipoprotein E/oestrogen receptor-alpha knock-out mice. Experimental Physiology. 93: 658-64. PMID 18192335 DOI: 10.1113/expphysiol.2007.041806  0.96
2008 Makhanova N, Hagaman J, Kim HS, Smithies O. Salt-sensitive blood pressure in mice with increased expression of aldosterone synthase. Hypertension. 51: 134-40. PMID 18039983 DOI: 10.1161/HYPERTENSIONAHA.107.098897  0.96
2007 Hakim ZS, DiMichele LA, Doherty JT, Homeister JW, Beggs HE, Reichardt LF, Schwartz RJ, Brackhan J, Smithies O, Mack CP, Taylor JM. Conditional deletion of focal adhesion kinase leads to defects in ventricular septation and outflow tract alignment. Molecular and Cellular Biology. 27: 5352-64. PMID 17526730 DOI: 10.1128/MCB.00068-07  0.96
2007 Dackor R, Fritz-Six K, Smithies O, Caron K. Receptor activity-modifying proteins 2 and 3 have distinct physiological functions from embryogenesis to old age. The Journal of Biological Chemistry. 282: 18094-9. PMID 17470425 DOI: 10.1074/jbc.M703544200  0.96
2007 Kakoki M, McGarrah RW, Kim HS, Smithies O. Bradykinin B1 and B2 receptors both have protective roles in renal ischemia/reperfusion injury. Proceedings of the National Academy of Sciences of the United States of America. 104: 7576-81. PMID 17452647 DOI: 10.1073/pnas.0701617104  0.96
2007 Yamaguchi N, Takahashi N, Xu L, Smithies O, Meissner G. Early cardiac hypertrophy in mice with impaired calmodulin regulation of cardiac muscle Ca release channel. The Journal of Clinical Investigation. 117: 1344-53. PMID 17431507 DOI: 10.1172/JCI29515  0.96
2007 Caron K, Hagaman J, Nishikimi T, Kim HS, Smithies O. Adrenomedullin gene expression differences in mice do not affect blood pressure but modulate hypertension-induced pathology in males. Proceedings of the National Academy of Sciences of the United States of America. 104: 3420-5. PMID 17360661 DOI: 10.1073/pnas.0611365104  0.96
2007 Ellmers LJ, Scott NJ, Piuhola J, Maeda N, Smithies O, Frampton CM, Richards AM, Cameron VA. Npr1-regulated gene pathways contributing to cardiac hypertrophy and fibrosis. Journal of Molecular Endocrinology. 38: 245-57. PMID 17293444 DOI: 10.1677/jme.1.02138  0.96
2006 Crowley SD, Gurley SB, Herrera MJ, Ruiz P, Griffiths R, Kumar AP, Kim HS, Smithies O, Le TH, Coffman TM. Angiotensin II causes hypertension and cardiac hypertrophy through its receptors in the kidney. Proceedings of the National Academy of Sciences of the United States of America. 103: 17985-90. PMID 17090678 DOI: 10.1073/pnas.0605545103  0.96
2006 Makhanova N, Sequeira-Lopez ML, Gomez RA, Kim HS, Smithies O. Disturbed homeostasis in sodium-restricted mice heterozygous and homozygous for aldosterone synthase gene disruption. Hypertension. 48: 1151-9. PMID 17075030 DOI: 10.1161/01.HYP.0000249902.09036.e7  0.96
2006 Pandya K, Kim HS, Smithies O. Fibrosis, not cell size, delineates beta-myosin heavy chain reexpression during cardiac hypertrophy and normal aging in vivo. Proceedings of the National Academy of Sciences of the United States of America. 103: 16864-9. PMID 17068123 DOI: 10.1073/pnas.0607700103  0.96
2006 Li M, Yee D, Magnuson TR, Smithies O, Caron KM. Reduced maternal expression of adrenomedullin disrupts fertility, placentation, and fetal growth in mice. The Journal of Clinical Investigation. 116: 2653-62. PMID 16981008 DOI: 10.1172/JCI28462  0.96
2006 Yasuda O, Fukuo K, Sun X, Nishitani M, Yotsui T, Higuchi M, Suzuki T, Rakugi H, Smithies O, Maeda N, Ogihara T. Apop-1, a novel protein inducing cyclophilin D-dependent but Bax/Bak-related channel-independent apoptosis. The Journal of Biological Chemistry. 281: 23899-907. PMID 16782708 DOI: 10.1074/jbc.M512610200  0.96
2006 Ciavatta D, Kalantry S, Magnuson T, Smithies O. A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation. Proceedings of the National Academy of Sciences of the United States of America. 103: 9958-63. PMID 16777957 DOI: 10.1073/pnas.0603754103  0.96
2006 Perrino C, Naga Prasad SV, Mao L, Noma T, Yan Z, Kim HS, Smithies O, Rockman HA. Intermittent pressure overload triggers hypertrophy-independent cardiac dysfunction and vascular rarefaction. The Journal of Clinical Investigation. 116: 1547-60. PMID 16741575 DOI: 10.1172/JCI25397  0.96
2006 Kakoki M, Kizer CM, Yi X, Takahashi N, Kim HS, Bagnell CR, Edgell CJ, Maeda N, Jennette JC, Smithies O. Senescence-associated phenotypes in Akita diabetic mice are enhanced by absence of bradykinin B2 receptors. The Journal of Clinical Investigation. 116: 1302-9. PMID 16604193 DOI: 10.1172/JCI26958  0.96
2006 Kakoki M, Kim HS, Edgell CJ, Maeda N, Smithies O, Mattson DL. Amino acids as modulators of endothelium-derived nitric oxide. American Journal of Physiology. Renal Physiology. 291: F297-304. PMID 16571593 DOI: 10.1152/ajprenal.00417.2005  0.96
2006 Dackor RT, Fritz-Six K, Dunworth WP, Gibbons CL, Smithies O, Caron KM. Hydrops fetalis, cardiovascular defects, and embryonic lethality in mice lacking the calcitonin receptor-like receptor gene. Molecular and Cellular Biology. 26: 2511-8. PMID 16537897 DOI: 10.1128/MCB.26.7.2511-2518.2006  0.96
2006 Makhanova N, Lee G, Takahashi N, Sequeira Lopez ML, Gomez RA, Kim HS, Smithies O. Kidney function in mice lacking aldosterone. American Journal of Physiology. Renal Physiology. 290: F61-9. PMID 16118390 DOI: 10.1152/ajprenal.00257.2005  0.96
2005 Hatada S, Arnold LW, Hatada T, Cowhig JE, Ciavatta D, Smithies O. Isolating gene-corrected stem cells without drug selection. Proceedings of the National Academy of Sciences of the United States of America. 102: 16357-61. PMID 16258059 DOI: 10.1073/pnas.0508263102  0.96
2005 Hagaman JR, John S, Xu L, Smithies O, Maeda N. An improved technique for tail-cuff blood pressure measurements with dark-tailed mice. Contemporary Topics in Laboratory Animal Science / American Association For Laboratory Animal Science. 44: 43-6. PMID 16138782  0.96
2005 Smithies O. An interview with... Oliver Smithies [interviewed by Magdalena Skipper]. Nature Reviews. Genetics. 6: 350. PMID 15880879 DOI: 10.1038/nrg1627  0.96
2005 Smithies O. Many little things: one geneticist's view of complex diseases. Nature Reviews. Genetics. 6: 419-25. PMID 15861211 DOI: 10.1038/nrg1605  0.96
2005 Crowley SD, Gurley SB, Oliverio MI, Pazmino AK, Griffiths R, Flannery PJ, Spurney RF, Kim HS, Smithies O, Le TH, Coffman TM. Distinct roles for the kidney and systemic tissues in blood pressure regulation by the renin-angiotensin system. The Journal of Clinical Investigation. 115: 1092-9. PMID 15841186 DOI: 10.1172/JCI23378  0.96
2005 Nishikimi T, Hagaman JR, Takahashi N, Kim HS, Matsuoka H, Smithies O, Maeda N. Increased susceptibility to heart failure in response to volume overload in mice lacking natriuretic peptide receptor-A gene. Cardiovascular Research. 66: 94-103. PMID 15769452 DOI: 10.1016/j.cardiores.2004.12.014  0.96
2005 Lee G, Makhanova N, Caron K, Lopez ML, Gomez RA, Smithies O, Kim HS. Homeostatic responses in the adrenal cortex to the absence of aldosterone in mice. Endocrinology. 146: 2650-6. PMID 15731365 DOI: 10.1210/en.2004-1102  0.96
2005 Fair JH, Cairns BA, Lapaglia MA, Caballero M, Pleasant WA, Hatada S, Kim HS, Gui T, Pevny L, Meyer AA, Stafford DW, Smithies O, Frelinger JA. Correction of factor IX deficiency in mice by embryonic stem cells differentiated in vitro. Proceedings of the National Academy of Sciences of the United States of America. 102: 2958-63. PMID 15699326 DOI: 10.1073/pnas.0409840102  0.96
2005 Caron KM, James LR, Lee G, Kim HS, Smithies O. Lifelong genetic minipumps. Physiological Genomics. 20: 203-9. PMID 15585607 DOI: 10.1152/physiolgenomics.00221.2004  0.96
2005 Takahashi N, Lopez ML, Cowhig JE, Taylor MA, Hatada T, Riggs E, Lee G, Gomez RA, Kim HS, Smithies O. Ren1c homozygous null mice are hypotensive and polyuric, but heterozygotes are indistinguishable from wild-type. Journal of the American Society of Nephrology : Jasn. 16: 125-32. PMID 15563565 DOI: 10.1681/ASN.2004060490  0.96
2004 Cohen SM, Hatada S, Brylawski BP, Smithies O, Kaufman DG, Cordeiro-Stone M. Complementation of replication origin function in mouse embryonic stem cells by human DNA sequences. Genomics. 84: 475-84. PMID 15498455 DOI: 10.1016/j.ygeno.2004.04.008  0.96
2004 Jiang Y, Pandya K, Smithies O, Hsu EW. Three-dimensional diffusion tensor microscopy of fixed mouse hearts. Magnetic Resonance in Medicine : Official Journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine. 52: 453-60. PMID 15334561 DOI: 10.1002/mrm.20191  0.96
2004 Kakoki M, Takahashi N, Jennette JC, Smithies O. Diabetic nephropathy is markedly enhanced in mice lacking the bradykinin B2 receptor. Proceedings of the National Academy of Sciences of the United States of America. 101: 13302-5. PMID 15326315 DOI: 10.1073/pnas.0405449101  0.96
2004 Le TH, Oliverio MI, Kim HS, Salzler H, Dash RC, Howell DN, Smithies O, Bronson S, Coffman TM. A gammaGT-AT1A receptor transgene protects renal cortical structure in AT1 receptor-deficient mice. Physiological Genomics. 18: 290-8. PMID 15306694 DOI: 10.1152/physiolgenomics.00120.2003  0.96
2004 Goulet JL, Pace AJ, Key ML, Byrum RS, Nguyen M, Tilley SL, Morham SG, Langenbach R, Stock JL, McNeish JD, Smithies O, Coffman TM, Koller BH. E-prostanoid-3 receptors mediate the proinflammatory actions of prostaglandin E2 in acute cutaneous inflammation. Journal of Immunology (Baltimore, Md. : 1950). 173: 1321-6. PMID 15240726  0.96
2004 Sequeira López ML, Pentz ES, Nomasa T, Smithies O, Gomez RA. Renin cells are precursors for multiple cell types that switch to the renin phenotype when homeostasis is threatened. Developmental Cell. 6: 719-28. PMID 15130496 DOI: 10.1016/S1534-5807(04)00134-0  0.96
2004 Kakoki M, Tsai YS, Kim HS, Hatada S, Ciavatta DJ, Takahashi N, Arnold LW, Maeda N, Smithies O. Altering the expression in mice of genes by modifying their 3' regions. Developmental Cell. 6: 597-606. PMID 15068798 DOI: 10.1016/S1534-5807(04)00094-2  0.96
2004 Takahashi N, Smithies O. Human genetics, animal models and computer simulations for studying hypertension. Trends in Genetics : Tig. 20: 136-45. PMID 15036807 DOI: 10.1016/j.tig.2004.01.004  0.96
2004 Caron KM, James LR, Kim HS, Knowles J, Uhlir R, Mao L, Hagaman JR, Cascio W, Rockman H, Smithies O. Cardiac hypertrophy and sudden death in mice with a genetically clamped renin transgene. Proceedings of the National Academy of Sciences of the United States of America. 101: 3106-11. PMID 14978280 DOI: 10.1073/pnas.0307333101  0.96
2003 Le TH, Kim HS, Allen AM, Spurney RF, Smithies O, Coffman TM. Physiological impact of increased expression of the AT1 angiotensin receptor. Hypertension. 42: 507-14. PMID 12963678 DOI: 10.1161/01.HYP.0000092000.07559.57  0.96
2003 Fair JH, Cairns BA, Lapaglia M, Wang J, Meyer AA, Kim H, Hatada S, Smithies O, Pevny L. Induction of hepatic differentiation in embryonic stem cells by co-culture with embryonic cardiac mesoderm. Surgery. 134: 189-96. PMID 12947317 DOI: 10.1067/msy.2003.225  0.96
2003 Garey J, Goodwillie A, Frohlich J, Morgan M, Gustafsson JA, Smithies O, Korach KS, Ogawa S, Pfaff DW. Genetic contributions to generalized arousal of brain and behavior. Proceedings of the National Academy of Sciences of the United States of America. 100: 11019-22. PMID 12930901 DOI: 10.1073/pnas.1633773100  0.96
2003 Shi SJ, Vellaichamy E, Chin SY, Smithies O, Navar LG, Pandey KN. Natriuretic peptide receptor A mediates renal sodium excretory responses to blood volume expansion. American Journal of Physiology. Renal Physiology. 285: F694-702. PMID 12824076 DOI: 10.1152/ajprenal.00097.2003  0.96
2003 Takahashi N, Hagaman JR, Kim HS, Smithies O. Minireview: computer simulations of blood pressure regulation by the renin-angiotensin system. Endocrinology. 144: 2184-90. PMID 12746272 DOI: 10.1210/en.2002-221045  0.96
2003 Smithies O. Why the kidney glomerulus does not clog: a gel permeation/diffusion hypothesis of renal function. Proceedings of the National Academy of Sciences of the United States of America. 100: 4108-13. PMID 12655073 DOI: 10.1073/pnas.0730776100  0.96
2002 McDougall KE, Perry MJ, Gibson RL, Bright JM, Colley SM, Hodgin JB, Smithies O, Tobias JH. Estrogen-induced osteogenesis in intact female mice lacking ERbeta. American Journal of Physiology. Endocrinology and Metabolism. 283: E817-23. PMID 12217900 DOI: 10.1152/ajpendo.00071.2002  0.96
2002 Shim EH, Kim JI, Bang ES, Heo JS, Lee JS, Kim EY, Lee JE, Park WY, Kim SH, Kim HS, Smithies O, Jang JJ, Jin DI, Seo JS. Targeted disruption of hsp70.1 sensitizes to osmotic stress. Embo Reports. 3: 857-61. PMID 12189176 DOI: 10.1093/embo-reports/kvf175  0.96
2002 Ellmers LJ, Knowles JW, Kim HS, Smithies O, Maeda N, Cameron VA. Ventricular expression of natriuretic peptides in Npr1(-/-) mice with cardiac hypertrophy and fibrosis. American Journal of Physiology. Heart and Circulatory Physiology. 283: H707-14. PMID 12124219 DOI: 10.1152/ajpheart.00677.2001  0.96
2002 Caron KM, James LR, Kim HS, Morham SG, Sequeira Lopez ML, Gomez RA, Reudelhuber TL, Smithies O. A genetically clamped renin transgene for the induction of hypertension. Proceedings of the National Academy of Sciences of the United States of America. 99: 8248-52. PMID 12034874 DOI: 10.1073/pnas.112222199  0.96
2002 Caron KM, Smithies O. Multiple roles of adrenomedullin revealed by animal models. Microscopy Research and Technique. 57: 55-9. PMID 11921356 DOI: 10.1002/jemt.10046  0.96
2002 Kim HS, Lee G, John SW, Maeda N, Smithies O. Molecular phenotyping for analyzing subtle genetic effects in mice: application to an angiotensinogen gene titration. Proceedings of the National Academy of Sciences of the United States of America. 99: 4602-7. PMID 11904385 DOI: 10.1073/pnas.072083799  0.96
2002 Makino Y, Cook DN, Smithies O, Hwang OY, Neilson EG, Turka LA, Sato H, Wells AD, Danoff TM. Impaired T cell function in RANTES-deficient mice. Clinical Immunology (Orlando, Fla.). 102: 302-9. PMID 11890717 DOI: 10.1006/clim.2001.5178  0.96
2002 Takahashi N, Brooks HL, Wade JB, Liu W, Kondo Y, Ito S, Knepper MA, Smithies O. Posttranscriptional compensation for heterozygous disruption of the kidney-specific NaK2Cl cotransporter gene. Journal of the American Society of Nephrology : Jasn. 13: 604-10. PMID 11856763  0.96
2002 Hodgin JB, Knowles JW, Kim HS, Smithies O, Maeda N. Interactions between endothelial nitric oxide synthase and sex hormones in vascular protection in mice. The Journal of Clinical Investigation. 109: 541-8. PMID 11854327 DOI: 10.1172/JCI14066  0.96
2002 Zhu Y, Bian Z, Lu P, Karas RH, Bao L, Cox D, Hodgin J, Shaul PW, Thoren P, Smithies O, Gustafsson JA, Mendelsohn ME. Abnormal vascular function and hypertension in mice deficient in estrogen receptor beta. Science (New York, N.Y.). 295: 505-8. PMID 11799247 DOI: 10.1126/science.1065250  0.96
2002 Klinger JR, Warburton RR, Pietras L, Oliver P, Fox J, Smithies O, Hill NS. Targeted disruption of the gene for natriuretic peptide receptor-A worsens hypoxia-induced cardiac hypertrophy. American Journal of Physiology. Heart and Circulatory Physiology. 282: H58-65. PMID 11748047  0.96
2001 Athirakul K, Kim HS, Audoly LP, Smithies O, Coffman TM. Deficiency of COX-1 causes natriuresis and enhanced sensitivity to ACE inhibition. Kidney International. 60: 2324-9. PMID 11737606 DOI: 10.1046/j.1523-1755.2001.00072.x  0.96
2001 Gerlofs-Nijland ME, Assmann KJ, Dijkman HB, Dieker JW, van Son JP, Mentzel S, van Kats JP, Danser AH, Smithies O, Groenen PJ, Wetzels JF. Albuminuria in mice after injection of antibodies against aminopeptidase A: role of angiotensin II. Journal of the American Society of Nephrology : Jasn. 12: 2711-20. PMID 11729240  0.96
2001 Huang W, Gallois Y, Bouby N, Bruneval P, Heudes D, Belair MF, Krege JH, Meneton P, Marre M, Smithies O, Alhenc-Gelas F. Genetically increased angiotensin I-converting enzyme level and renal complications in the diabetic mouse. Proceedings of the National Academy of Sciences of the United States of America. 98: 13330-4. PMID 11687636 DOI: 10.1073/pnas.231476798  0.96
2001 Capecchi MR. Generating mice with targeted mutations. Nature Medicine. 7: 1086-90. PMID 11590420 DOI: 10.1038/nm1001-1086  0.96
2001 Smithies O. Forty years with homologous recombination. Nature Medicine. 7: 1083-6. PMID 11590419 DOI: 10.1038/nm1001-1083  0.96
2001 Gilmore RC, Baker J, Dempsey S, Marchan R, Corprew RN, Byrd G, Maeda N, Smithies O, Bukoski RD, Harewood KR, Chatterjee PK. Using PAC nested deletions to order contigs and microsatellite markers at the high repetitive sequence containing Npr3 gene locus. Gene. 275: 65-72. PMID 11574153 DOI: 10.1016/S0378-1119(01)00654-0  0.96
2001 Goy MF, Oliver PM, Purdy KE, Knowles JW, Fox JE, Mohler PJ, Qian X, Smithies O, Maeda N. Evidence for a novel natriuretic peptide receptor that prefers brain natriuretic peptide over atrial natriuretic peptide. The Biochemical Journal. 358: 379-87. PMID 11513736 DOI: 10.1042/0264-6021:3580379  0.96
2001 Pentz ES, Lopez ML, Kim HS, Carretero O, Smithies O, Gomez RA. Ren1d and Ren2 cooperate to preserve homeostasis: evidence from mice expressing GFP in place of Ren1d. Physiological Genomics. 6: 45-55. PMID 11395546  0.96
2001 Knowles JW, Esposito G, Mao L, Hagaman JR, Fox JE, Smithies O, Rockman HA, Maeda N. Pressure-independent enhancement of cardiac hypertrophy in natriuretic peptide receptor A-deficient mice. The Journal of Clinical Investigation. 107: 975-84. PMID 11306601 DOI: 10.1172/JCI11273  0.96
2001 Hodgin JB, Krege JH, Reddick RL, Korach KS, Smithies O, Maeda N. Estrogen receptor alpha is a major mediator of 17beta-estradiol's atheroprotective effects on lesion size in Apoe-/- mice. The Journal of Clinical Investigation. 107: 333-40. PMID 11160157 DOI: 10.1172/JCI11320  0.96
2001 Loftin CD, Trivedi DB, Tiano HF, Clark JA, Lee CA, Epstein JA, Morham SG, Breyer MD, Nguyen M, Hawkins BM, Goulet JL, Smithies O, Koller BH, Langenbach R. Failure of ductus arteriosus closure and remodeling in neonatal mice deficient in cyclooxygenase-1 and cyclooxygenase-2. Proceedings of the National Academy of Sciences of the United States of America. 98: 1059-64. PMID 11158594 DOI: 10.1073/pnas.031573498  0.96
2001 Caron KM, Smithies O. Extreme hydrops fetalis and cardiovascular abnormalities in mice lacking a functional Adrenomedullin gene. Proceedings of the National Academy of Sciences of the United States of America. 98: 615-9. PMID 11149956 DOI: 10.1073/pnas.021548898  0.96
2001 Smithies O. Forty years with homologous recombinations Medicina. 61: 652.  0.96
2001 Smithies O. Mouse solutions to human problems Medicina. 61: 665.  0.96
2000 Norwood VF, Morham SG, Smithies O. Postnatal development and progression of renal dysplasia in cyclooxygenase-2 null mice. Kidney International. 58: 2291-300. PMID 11115063 DOI: 10.1046/j.1523-1755.2000.00413.x  0.96
2000 Smithies O, Kim HS, Takahashi N, Edgell MH. Importance of quantitative genetic variations in the etiology of hypertension. Kidney International. 58: 2265-80. PMID 11115061 DOI: 10.1046/j.1523-1755.2000.00411.x  0.96
2000 Ogawa S, Chester AE, Hewitt SC, Walker VR, Gustafsson JA, Smithies O, Korach KS, Pfaff DW. Abolition of male sexual behaviors in mice lacking estrogen receptors alpha and beta (alpha beta ERKO). Proceedings of the National Academy of Sciences of the United States of America. 97: 14737-41. PMID 11114183 DOI: 10.1073/pnas.250473597  0.96
2000 Hatada S, Nikkuni K, Bentley SA, Kirby S, Smithies O. Gene correction in hematopoietic progenitor cells by homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. 97: 13807-11. PMID 11087825 DOI: 10.1073/pnas.240462897  0.96
2000 Chulada PC, Thompson MB, Mahler JF, Doyle CM, Gaul BW, Lee C, Tiano HF, Morham SG, Smithies O, Langenbach R. Genetic disruption of Ptgs-1, as well as Ptgs-2, reduces intestinal tumorigenesis in Min mice. Cancer Research. 60: 4705-8. PMID 10987272  0.96
2000 Kirby S, Walton W, Smithies O. Hematopoietic stem cells with controllable tEpoR transgenes have a competitive advantage in bone marrow transplantation. Blood. 95: 3710-5. PMID 10845901  0.96
2000 Takahashi N, Chernavvsky DR, Gomez RA, Igarashi P, Gitelman HJ, Smithies O. Uncompensated polyuria in a mouse model of Bartter's syndrome. Proceedings of the National Academy of Sciences of the United States of America. 97: 5434-9. PMID 10779555 DOI: 10.1073/pnas.090091297  0.96
2000 Morteau O, Morham SG, Sellon R, Dieleman LA, Langenbach R, Smithies O, Sartor RB. Impaired mucosal defense to acute colonic injury in mice lacking cyclooxygenase-1 or cyclooxygenase-2. The Journal of Clinical Investigation. 105: 469-78. PMID 10683376 DOI: 10.1172/JCI6899  0.96
2000 Knowles JW, Reddick RL, Jennette JC, Shesely EG, Smithies O, Maeda N. Enhanced atherosclerosis and kidney dysfunction in eNOS(-/-)Apoe(-/-) mice are ameliorated by enalapril treatment. The Journal of Clinical Investigation. 105: 451-8. PMID 10683374 DOI: 10.1172/JCI8376  0.96
2000 Oliverio MI, Best CF, Smithies O, Coffman TM. Regulation of sodium balance and blood pressure by the AT(1A) receptor for angiotensin II. Hypertension. 35: 550-4. PMID 10679496  0.96
2000 Oliverio MI, Delnomdedieu M, Best CF, Li P, Morris M, Callahan MF, Johnson GA, Smithies O, Coffman TM. Abnormal water metabolism in mice lacking the type 1A receptor for ANG II. American Journal of Physiology. Renal Physiology. 278: F75-82. PMID 10644657  0.96
1999 Pandey KN, Oliver PM, Maeda N, Smithies O. Hypertension Associated with Decreased Testosterone Levels in Natriuretic Peptide Receptor-A Gene-Knockout and Gene-Duplicated Mutant Mouse Models1. Endocrinology. 140: 5112-5119. PMID 28204268 DOI: 10.1210/endo.140.11.7121  0.96
1999 Smithies O. Alexander George Ogston: 30 January 1911-29 June 1996. Biographical Memoirs of Fellows of the Royal Society. Royal Society (Great Britain). 45: 351-64. PMID 11624284  0.96
1999 Smithies O. Quantitative genetic variations and essential hypertension. Harvey Lectures. 95: 1-20. PMID 11446106  0.96
1999 Karas RH, Hodgin JB, Kwoun M, Krege JH, Aronovitz M, Mackey W, Gustafsson JA, Korach KS, Smithies O, Mendelsohn ME. Estrogen inhibits the vascular injury response in estrogen receptor beta-deficient female mice. Proceedings of the National Academy of Sciences of the United States of America. 96: 15133-6. PMID 10611350 DOI: 10.1073/pnas.96.26.15133  0.96
1999 Nataraj C, Oliverio MI, Mannon RB, Mannon PJ, Audoly LP, Amuchastegui CS, Ruiz P, Smithies O, Coffman TM. Angiotensin II regulates cellular immune responses through a calcineurin-dependent pathway. The Journal of Clinical Investigation. 104: 1693-701. PMID 10606623 DOI: 10.1172/JCI7451  0.96
1999 Pandey KN, Oliver PM, Maeda N, Smithies O. Hypertension associated with decreased testosterone levels in natriuretic peptide receptor-A gene-knockout and gene-duplicated mutant mouse models. Endocrinology. 140: 5112-9. PMID 10537139 DOI: 10.1210/endo.140.11.7121  0.96
1999 Takahashi N, Smithies O. Gene targeting approaches to analyzing hypertension. Journal of the American Society of Nephrology : Jasn. 10: 1598-605. PMID 10405217  0.96
1999 Matsukawa N, Grzesik WJ, Takahashi N, Pandey KN, Pang S, Yamauchi M, Smithies O. The natriuretic peptide clearance receptor locally modulates the physiological effects of the natriuretic peptide system. Proceedings of the National Academy of Sciences of the United States of America. 96: 7403-8. PMID 10377427 DOI: 10.1073/pnas.96.13.7403  0.96
1999 Traynor T, Yang T, Huang YG, Krege JH, Briggs JP, Smithies O, Schnermann J. Tubuloglomerular feedback in ACE-deficient mice. The American Journal of Physiology. 276: F751-7. PMID 10330057 DOI: 10.1152/ajprenal.1999.276.5.F751  0.96
1999 Klinger JR, Warburton RR, Pietras LA, Smithies O, Swift R, Hill NS. Genetic disruption of atrial natriuretic peptide causes pulmonary hypertension in normoxic and hypoxic mice. The American Journal of Physiology. 276: L868-74. PMID 10330043  0.96
1999 Kim HS, Maeda N, Oh GT, Fernandez LG, Gomez RA, Smithies O. Homeostasis in mice with genetically decreased angiotensinogen is primarily by an increased number of renin-producing cells. The Journal of Biological Chemistry. 274: 14210-7. PMID 10318840 DOI: 10.1074/jbc.274.20.14210  0.96
1999 Cook DN, Smithies O, Strieter RM, Frelinger JA, Serody JS. CD8+ T cells are a biologically relevant source of macrophage inflammatory protein-1 alpha in vivo. Journal of Immunology (Baltimore, Md. : 1950). 162: 5423-8. PMID 10228020  0.96
1999 Fern RJ, Yesko CM, Thornhill BA, Kim HS, Smithies O, Chevalier RL. Reduced angiotensinogen expression attenuates renal interstitial fibrosis in obstructive nephropathy in mice. The Journal of Clinical Investigation. 103: 39-46. PMID 9884332 DOI: 10.1172/JCI4236  0.96
1999 Hatada S, Kuziel W, Smithies O, Maeda N. The influence of chromosomal location on the expression of two transgenes in mice. The Journal of Biological Chemistry. 274: 948-55. PMID 9873036 DOI: 10.1074/jbc.274.2.948  0.96
1998 Oliverio MI, Madsen K, Best CF, Ito M, Maeda N, Smithies O, Coffman TM. Renal growth and development in mice lacking ATreceptors for angiotensin II. American Journal of Physiology. Renal Physiology. 274: F43-F50. PMID 29592628 DOI: 10.1152/ajprenal.1998.274.1.F43  0.96
1998 Krege JH, Hodgin JB, Couse JF, Enmark E, Warner M, Mahler JF, Sar M, Korach KS, Gustafsson JA, Smithies O. Generation and reproductive phenotypes of mice lacking estrogen receptor beta. Proceedings of the National Academy of Sciences of the United States of America. 95: 15677-82. PMID 9861029 DOI: 10.1073/pnas.95.26.15677  0.96
1998 Oliverio MI, Kim HS, Ito M, Le T, Audoly L, Best CF, Hiller S, Kluckman K, Maeda N, Smithies O, Coffman TM. Reduced growth, abnormal kidney structure, and type 2 (AT2) angiotensin receptor-mediated blood pressure regulation in mice lacking both AT1A and AT1B receptors for angiotensin II. Proceedings of the National Academy of Sciences of the United States of America. 95: 15496-501. PMID 9860997 DOI: 10.1073/pnas.95.26.15496  0.96
1998 Thomas DW, Mannon RB, Mannon PJ, Latour A, Oliver JA, Hoffman M, Smithies O, Koller BH, Coffman TM. Coagulation defects and altered hemodynamic responses in mice lacking receptors for thromboxane A2. The Journal of Clinical Investigation. 102: 1994-2001. PMID 9835625 DOI: 10.1172/JCI5116  0.96
1998 Thresher RJ, Vitaterna MH, Miyamoto Y, Kazantsev A, Hsu DS, Petit C, Selby CP, Dawut L, Smithies O, Takahashi JS, Sancar A. Role of mouse cryptochrome blue-light photoreceptor in circadian photoresponses. Science (New York, N.Y.). 282: 1490-4. PMID 9822380  0.96
1998 Whitney JB, Leder A, Lewis J, Popp RA, Paszty C, Rubin EM, Shehee WR, Townes TM, Smithies O. Rapid genotyping of mice with hemoglobinopathies and globin transgenes. Biochemical Genetics. 36: 65-77. PMID 9562907  0.72
1998 Tumpey TM, Cheng H, Cook DN, Smithies O, Oakes JE, Lausch RN. Absence of macrophage inflammatory protein-1alpha prevents the development of blinding herpes stromal keratitis. Journal of Virology. 72: 3705-10. PMID 9557652  0.96
1998 Lewis J, Yang B, Kim R, Sierakowska H, Kole R, Smithies O, Maeda N. A common human beta globin splicing mutation modeled in mice. Blood. 91: 2152-6. PMID 9490703  0.96
1998 Hagaman JR, Moyer JS, Bachman ES, Sibony M, Magyar PL, Welch JE, Smithies O, Krege JH, O'Brien DA. Angiotensin-converting enzyme and male fertility. Proceedings of the National Academy of Sciences of the United States of America. 95: 2552-7. PMID 9482924 DOI: 10.1073/pnas.95.5.2552  0.96
1998 Oliver PM, John SW, Purdy KE, Kim R, Maeda N, Goy MF, Smithies O. Natriuretic peptide receptor 1 expression influences blood pressures of mice in a dose-dependent manner. Proceedings of the National Academy of Sciences of the United States of America. 95: 2547-51. PMID 9482923 DOI: 10.1073/pnas.95.5.2547  0.96
1998 Rudic RD, Shesely EG, Maeda N, Smithies O, Segal SS, Sessa WC. Direct evidence for the importance of endothelium-derived nitric oxide in vascular remodeling. The Journal of Clinical Investigation. 101: 731-6. PMID 9466966 DOI: 10.1172/JCI1699  0.96
1998 Oliverio MI, Madsen K, Best CF, Ito M, Maeda N, Smithies O, Coffman TM. Renal growth and development in mice lacking AT1A receptors for angiotensin II. The American Journal of Physiology. 274: F43-50. PMID 9458822  0.96
1998 Kirby S, Wallon W, Smithies O. Erythropoietin-induced competitive expansion of transplanted tepor transgenic hematopoietic stem cells in vivo Experimental Hematology. 26: 814.  0.96
1997 Oliver PM, Fox JE, Kim R, Rockman HA, Kim HS, Reddick RL, Pandey KN, Milgram SL, Smithies O, Maeda N. Hypertension, cardiac hypertrophy, and sudden death in mice lacking natriuretic peptide receptor A. Proceedings of the National Academy of Sciences of the United States of America. 94: 14730-5. PMID 9405681 DOI: 10.1073/pnas.94.26.14730  0.96
1997 Smithies O. Theodore Cooper Memorial Lecture. A mouse view of hypertension. Hypertension. 30: 1318-24. PMID 9403547  0.96
1997 Lin HF, Maeda N, Smithies O, Straight DL, Stafford DW. A coagulation factor IX-deficient mouse model for human hemophilia B. Blood. 90: 3962-6. PMID 9354664  0.96
1997 Kuziel WA, Morgan SJ, Dawson TC, Griffin S, Smithies O, Ley K, Maeda N. Severe reduction in leukocyte adhesion and monocyte extravasation in mice deficient in CC chemokine receptor 2. Proceedings of the National Academy of Sciences of the United States of America. 94: 12053-8. PMID 9342361 DOI: 10.1073/pnas.94.22.12053  0.96
1997 Morham SG, Langenbach R, Mahler J, Smithies O. Characterization of prostaglandin H synthase 2 deficient mice and implications for mechanisms of NSAID action. Advances in Experimental Medicine and Biology. 407: 131-8. PMID 9321943  0.96
1997 Savinova OV, Matsukawa N, Smithies O, John SW. Mouse natriuretic peptide receptor 3 gene maps to proximal chromosome 15. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 8: 788. PMID 9321481 DOI: 10.1007/s003359900571  0.96
1997 Krege JH, Moyer JS, Langenbach LL, Peng L, Zhang SH, Maeda N, Reddick RL, Smithies O. Angiotensin-converting enzyme gene and atherosclerosis. Arteriosclerosis, Thrombosis, and Vascular Biology. 17: 1245-50. PMID 9261253  0.96
1997 Tian B, Meng QC, Chen YF, Krege JH, Smithies O, Oparil S. Blood pressures and cardiovascular homeostasis in mice having reduced or absent angiotensin-converting enzyme gene function. Hypertension. 30: 128-33. PMID 9231832  0.96
1997 Tsuda H, Maynard-Currie CE, Reid LH, Yoshida T, Edamura K, Maeda N, Smithies O, Jakobovits A. Inactivation of the mouse HPRT locus by a 203-bp retroposon insertion and a 55-kb gene-targeted deletion: establishment of new HPRT-deficient mouse embryonic stem cell lines. Genomics. 42: 413-21. PMID 9205113 DOI: 10.1006/geno.1997.4771  0.96
1997 Oliverio MI, Best CF, Kim HS, Arendshorst WJ, Smithies O, Coffman TM. Angiotensin II responses in AT1A receptor-deficient mice: a role for AT1B receptors in blood pressure regulation. The American Journal of Physiology. 272: F515-20. PMID 9140053  0.96
1997 MacTaggart TE, Ito M, Smithies O, John SW. Mouse angiotensin receptor genes Agtr1a and Agtr1b map to chromosomes 13 and 3. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 8: 294-5. PMID 9096120 DOI: 10.1007/s003359900419  0.96
1997 Davisson RL, Kim HS, Krege JH, Lager DJ, Smithies O, Sigmund CD. Complementation of reduced survival, hypotension, and renal abnormalities in angiotensinogen-deficient mice by the human renin and human angiotensinogen genes. The Journal of Clinical Investigation. 99: 1258-64. PMID 9077534 DOI: 10.1172/JCI119283  0.96
1997 Hilgers KF, Reddi V, Krege JH, Smithies O, Gomez RA. Aberrant renal vascular morphology and renin expression in mutant mice lacking angiotensin-converting enzyme. Hypertension. 29: 216-21. PMID 9039105  0.96
1997 Krege JH, Kim HS, Moyer JS, Jennette JC, Peng L, Hiller SK, Smithies O. Angiotensin-converting enzyme gene mutations, blood pressures, and cardiovascular homeostasis. Hypertension. 29: 150-7. PMID 9039095  0.96
1997 Oliverio MI, Best CF, Kim HS, Arendshorst WJ, Smithies O, Coffman TM. Angiotensin II responses in at 1A receptor-deficient mice: A role for at 1B receptors in blood pressure regulation American Journal of Physiology. 272: F521-F530.  0.96
1996 Morham SG, Kluckman KD, Voulomanos N, Smithies O. Targeted disruption of the mouse topoisomerase I gene by camptothecin selection. Molecular and Cellular Biology. 16: 6804-9. PMID 8943335  0.96
1996 Toth LR, Smith TJ, Jones C, de Silva HV, Smithies O, Maeda N. Two distinct apolipoprotein B alleles in mice generated by a single 'in-out' targeting. Gene. 178: 161-8. PMID 8921909 DOI: 10.1016/0378-1119(96)00360-5  0.96
1996 Shesely EG, Maeda N, Kim HS, Desai KM, Krege JH, Laubach VE, Sherman PA, Sessa WC, Smithies O. Elevated blood pressures in mice lacking endothelial nitric oxide synthase. Proceedings of the National Academy of Sciences of the United States of America. 93: 13176-81. PMID 8917564 DOI: 10.1073/pnas.93.23.13176  0.96
1996 Bozza PT, Payne JL, Morham SG, Langenbach R, Smithies O, Weller PF. Leukocyte lipid body formation and eicosanoid generation: cyclooxygenase-independent inhibition by aspirin. Proceedings of the National Academy of Sciences of the United States of America. 93: 11091-6. PMID 8855314 DOI: 10.1073/pnas.93.20.11091  0.96
1996 Bronson SK, Plaehn EG, Kluckman KD, Hagaman JR, Maeda N, Smithies O. Single-copy transgenic mice with chosen-site integration. Proceedings of the National Academy of Sciences of the United States of America. 93: 9067-72. PMID 8799155 DOI: 10.1073/pnas.93.17.9067  0.96
1996 Kirby SL, Cook DN, Walton W, Smithies O. Proliferation of multipotent hematopoietic cells controlled by a truncated erythropoietin receptor transgene. Proceedings of the National Academy of Sciences of the United States of America. 93: 9402-7. PMID 8790342 DOI: 10.1073/pnas.93.18.9402  0.96
1996 John SW, Veress AT, Honrath U, Chong CK, Peng L, Smithies O, Sonnenberg H. Blood pressure and fluid-electrolyte balance in mice with reduced or absent ANP. The American Journal of Physiology. 271: R109-14. PMID 8760210  0.96
1996 Lewis J, Yang B, Detloff P, Smithies O. Gene modification via "plug and socket" gene targeting. The Journal of Clinical Investigation. 97: 3-5. PMID 8550847 DOI: 10.1172/JCI118403  0.96
1996 Davisson RL, Kim HS, Krege JH, Smithies O, Sigmurid CD. Development oh transgenic mice containing a functional human, but lacking a functional mouse reninangiotensin system Faseb Journal. 10: A21.  0.96
1996 Davisson RL, Ding Y, Kirn HS, Krege JH, Hardy DO, Catterall JF, Smithies O, Siymund CD. Development of transgenic animal models for studying the renin-angiotensin system in hypertension. Renal function and renal development Journal of Investigative Medicine. 44: 321a.  0.96
1995 Couse JF, Curtis SW, Washburn TF, Lindzey J, Golding TS, Lubahn DB, Smithies O, Korach KS. Analysis of transcription and estrogen insensitivity in the female mouse after targeted disruption of the estrogen receptor gene. Molecular Endocrinology (Baltimore, Md.). 9: 1441-54. PMID 8584021 DOI: 10.1210/mend.9.11.8584021  0.96
1995 Yang B, Kirby S, Lewis J, Detloff PJ, Maeda N, Smithies O. A mouse model for beta 0-thalassemia. Proceedings of the National Academy of Sciences of the United States of America. 92: 11608-12. PMID 8524813 DOI: 10.1073/pnas.92.25.11608  0.96
1995 Langenbach R, Morham SG, Tiano HF, Loftin CD, Ghanayem BI, Chulada PC, Mahler JF, Lee CA, Goulding EH, Kluckman KD, Kim HS, Smithies O. Prostaglandin synthase 1 gene disruption in mice reduces arachidonic acid-induced inflammation and indomethacin-induced gastric ulceration. Cell. 83: 483-92. PMID 8521478 DOI: 10.1016/0092-8674(95)90126-4  0.96
1995 Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, Jennette JC, Mahler JF, Kluckman KD, Ledford A, Lee CA, Smithies O. Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell. 83: 473-82. PMID 8521477 DOI: 10.1016/0092-8674(95)90125-6  0.96
1995 John SW, Krege JH, Oliver PM, Hagaman JR, Hodgin JB, Pang SC, Flynn TG, Smithies O. Genetic decreases in atrial natriuretic peptide and salt-sensitive hypertension. Science (New York, N.Y.). 267: 679-81. PMID 7839143  0.96
1995 Smithies O, Maeda N. Gene targeting approaches to complex genetic diseases: atherosclerosis and essential hypertension. Proceedings of the National Academy of Sciences of the United States of America. 92: 5266-72. PMID 7777495 DOI: 10.1073/pnas.92.12.5266  0.96
1995 Krege JH, John SW, Langenbach LL, Hodgin JB, Hagaman JR, Bachman ES, Jennette JC, O'Brien DA, Smithies O. Male-female differences in fertility and blood pressure in ACE-deficient mice. Nature. 375: 146-8. PMID 7753170 DOI: 10.1038/375146a0  0.96
1995 Krege JH, Hodgin JB, Hagaman JR, Smithies O. A noninvasive computerized tail-cuff system for measuring blood pressure in mice. Hypertension. 25: 1111-5. PMID 7737724 DOI: 10.1161/01.HYP.25.5.1111  0.96
1995 Ito M, Oliverio MI, Mannon PJ, Best CF, Maeda N, Smithies O, Coffman TM. Regulation of blood pressure by the type 1A angiotensin II receptor gene. Proceedings of the National Academy of Sciences of the United States of America. 92: 3521-5. PMID 7724593 DOI: 10.1073/pnas.92.8.3521  0.96
1995 Bronson SK, Smithies O, Mascarello JT. High incidence of XXY and XYY males among the offspring of female chimeras from embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 92: 3120-3. PMID 7724525  0.96
1995 Kim HS, Krege JH, Kluckman KD, Hagaman JR, Hodgin JB, Best CF, Jennette JC, Coffman TM, Maeda N, Smithies O. Genetic control of blood pressure and the angiotensinogen locus. Proceedings of the National Academy of Sciences of the United States of America. 92: 2735-9. PMID 7708716 DOI: 10.1073/pnas.92.7.2735  0.96
1995 Smithies O. Early days of gel electrophoresis. Genetics. 139: 1-4. PMID 7705616  0.96
1995 Cook DN, Beck MA, Coffman TM, Kirby SL, Sheridan JF, Pragnell IB, Smithies O. Requirement of MIP-1 alpha for an inflammatory response to viral infection. Science (New York, N.Y.). 269: 1583-5. PMID 7667639 DOI: 10.1126/science.7667639  0.96
1995 Laubach VE, Shesely EG, Smithies O, Sherman PA. Mice lacking inducible nitric oxide synthase are not resistant to lipopolysaccharide-induced death. Proceedings of the National Academy of Sciences of the United States of America. 92: 10688-92. PMID 7479866 DOI: 10.1073/pnas.92.23.10688  0.96
1994 Nadeau J, Wold B, Bernstein A, Davis R, Helwig U, Hogan B, Housman D, Klausner R, Smithies O, Graham B. Technology advancement for studying gene expression and gene function: A workshop report - National Institutes of Health Mammalian Genome. 5: 127-130. PMID 8199399  0.96
1994 Smithies O, Kim HS. Targeted gene duplication and disruption for analyzing quantitative genetic traits in mice. Proceedings of the National Academy of Sciences of the United States of America. 91: 3612-5. PMID 8170956  0.96
1994 Bronson SK, Smithies O. Altering mice by homologous recombination using embryonic stem cells. The Journal of Biological Chemistry. 269: 27155-8. PMID 7961620  0.96
1994 Detloff PJ, Lewis J, John SW, Shehee WR, Langenbach R, Maeda N, Smithies O. Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy. Molecular and Cellular Biology. 14: 6936-43. PMID 7935410  0.96
1993 Luetteke NC, Qiu TH, Peiffer RL, Oliver P, Smithies O, Lee DC. TGF alpha deficiency results in hair follicle and eye abnormalities in targeted and waved-1 mice. Cell. 73: 263-78. PMID 8477445 DOI: 10.1016/0092-8674(93)90228-I  0.96
1993 Desai NM, Bassiri H, Kim J, Koller BH, Smithies O, Barker CF, Naji A, Markmann JF. Islet allograft, islet xenograft, and skin allograft survival in CD8+ T lymphocyte-deficient mice. Transplantation. 55: 718-22. PMID 8475541 DOI: 10.1097/00007890-199304000-00006  0.96
1993 Shehee WR, Oliver P, Smithies O. Lethal thalassemia after insertional disruption of the mouse major adult beta-globin gene. Proceedings of the National Academy of Sciences of the United States of America. 90: 3177-81. PMID 8475058  0.96
1993 Desai NM, Bassiri H, Odorico JS, Koller BH, Smithies O, Naji A, Barker CF, Markmann JF. Pancreatic islet allograft and xenograft survival in CD8+ T-lymphocyte-deficient recipients. Transplantation Proceedings. 25: 961-2. PMID 8442280  0.96
1993 Kim HS, Lyons KM, Saitoh E, Azen EA, Smithies O, Maeda N. The structure and evolution of the human salivary proline-rich protein gene family. Mammalian Genome : Official Journal of the International Mammalian Genome Society. 4: 3-14. PMID 8422499 DOI: 10.1007/BF00364656  0.96
1993 Coffman T, Geier S, Ibrahim S, Griffiths R, Spurney R, Smithies O, Koller B, Sanfilippo F. Improved renal function in mouse kidney allografts lacking MHC class I antigens. Journal of Immunology (Baltimore, Md. : 1950). 151: 425-35. PMID 8326135  0.96
1993 Lubahn DB, Moyer JS, Golding TS, Couse JF, Korach KS, Smithies O. Alteration of reproductive function but not prenatal sexual development after insertional disruption of the mouse estrogen receptor gene. Proceedings of the National Academy of Sciences of the United States of America. 90: 11162-6. PMID 8248223  0.96
1992 Spriggs MK, Koller BH, Sato T, Morrissey PJ, Fanslow WC, Smithies O, Voice RF, Widmer MB, Maliszewski CR. Beta 2-microglobulin-, CD8+ T-cell-deficient mice survive inoculation with high doses of vaccinia virus and exhibit altered IgG responses. Proceedings of the National Academy of Sciences of the United States of America. 89: 6070-4. PMID 1631092 DOI: 10.1073/pnas.89.13.6070  0.96
1992 Koller BH, Smithies O. Altering genes in animals by gene targeting. Annual Review of Immunology. 10: 705-30. PMID 1591000 DOI: 10.1146/annurev.iy.10.040192.003421  0.96
1992 Markmann JF, Bassiri H, Desai NM, Odorico JS, Kim JI, Koller BH, Smithies O, Barker CF. Indefinite survival of MHC class I-deficient murine pancreatic islet allografts. Transplantation. 54: 1085-9. PMID 1465773 DOI: 10.1097/00007890-199212000-00025  0.96
1992 Clarke LL, Grubb BR, Gabriel SE, Smithies O, Koller BH, Boucher RC. Defective epithelial chloride transport in a gene-targeted mouse model of cystic fibrosis. Science (New York, N.Y.). 257: 1125-8. PMID 1380724 DOI: 10.1126/science.257.5073.1125  0.96
1992 Snouwaert JN, Brigman KK, Latour AM, Malouf NN, Boucher RC, Smithies O, Koller BH. An animal model for cystic fibrosis made by gene targeting. Science (New York, N.Y.). 257: 1083-8. PMID 1380723 DOI: 10.1126/science.257.5073.1083  0.96
1991 Metzenberg AB, Wurzer G, Huisman TH, Smithies O. Homology requirements for unequal crossing over in humans. Genetics. 128: 143-61. PMID 2060774  0.96
1991 Shesely EG, Kim HS, Shehee WR, Papayannopoulou T, Smithies O, Popovich BW. Correction of a human beta S-globin gene by gene targeting. Proceedings of the National Academy of Sciences of the United States of America. 88: 4294-8. PMID 2034673  0.48
1991 Kim HS, Popovich BW, Shehee WR, Shesely EG, Smithies O. Problems encountered in detecting a targeted gene by the polymerase chain reaction. Gene. 103: 227-33. PMID 1889748  0.48
1991 Reid LH, Shesely EG, Kim HS, Smithies O. Cotransformation and gene targeting in mouse embryonic stem cells. Molecular and Cellular Biology. 11: 2769-77. PMID 1850104  0.48
1991 Koller BH, Kim HS, Latour AM, Brigman K, Boucher RC, Scambler P, Wainwright B, Smithies O. Toward an animal model of cystic fibrosis: targeted interruption of exon 10 of the cystic fibrosis transmembrane regulator gene in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 88: 10730-4. PMID 1720548 DOI: 10.1073/pnas.88.23.10730  0.96
1991 Schwartz F, Maeda N, Smithies O, Hickey R, Edelmann W, Skoultchi A, Kucherlapati R. A dominant positive and negative selectable gene for use in mammalian cells. Proceedings of the National Academy of Sciences of the United States of America. 88: 10416-20. PMID 1720540 DOI: 10.1073/pnas.88.23.10416  0.96
1990 Reid LH, Gregg RG, Smithies O, Koller BH. Regulatory elements in the introns of the human HPRT gene are necessary for its expression in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 87: 4299-303. PMID 2349238  0.96
1990 Kim HS, Smithies O, Maeda N. A physical map of the human salivary proline-rich protein gene cluster covers over 700 kbp of DNA. Genomics. 6: 260-7. PMID 2307469  0.96
1990 Koller BH, Marrack P, Kappler JW, Smithies O. Normal development of mice deficient in beta 2M, MHC class I proteins, and CD8+ T cells. Science (New York, N.Y.). 248: 1227-30. PMID 2112266  0.96
1989 Koller BH, Smithies O. Inactivating the beta 2-microglobulin locus in mouse embryonic stem cells by homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. 86: 8932-5. PMID 2682666  0.96
1989 Koller BH, Hagemann LJ, Doetschman T, Hagaman JR, Huang S, Williams PJ, First NL, Maeda N, Smithies O. Germ-line transmission of a planned alteration made in a hypoxanthine phosphoribosyltransferase gene by homologous recombination in embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 86: 8927-31. PMID 2573070 DOI: 10.1073/pnas.86.22.8927  0.96
1988 Nandi AK, Roginski RS, Gregg RG, Smithies O, Skoultchi AI. Regulated expression of genes inserted at the human chromosomal beta-globin locus by homologous recombination. Proceedings of the National Academy of Sciences of the United States of America. 85: 3845-9. PMID 3375244  0.96
1988 Lyons KM, Azen EA, Goodman PA, Smithies O. Many protein products from a few loci: assignment of human salivary proline-rich proteins to specific loci. Genetics. 120: 255-65. PMID 3220251  0.96
1988 Saitoh E, Isemura S, Sanada K, Kim HS, Smithies O, Maeda N. Cystatin superfamily. Evidence that family II cystatin genes are evolutionarily related to family III cystatin genes. Biological Chemistry Hoppe-Seyler. 369: 191-7. PMID 3202964  0.96
1988 Doetschman T, Maeda N, Smithies O. Targeted mutation of the Hprt gene in mouse embryonic stem cells. Proceedings of the National Academy of Sciences of the United States of America. 85: 8583-7. PMID 3186749 DOI: 10.1073/pnas.85.22.8583  0.96
1988 Kim HS, Smithies O. Recombinant fragment assay for gene targetting based on the polymerase chain reaction. Nucleic Acids Research. 16: 8887-903. PMID 3174435  0.48
1988 Maeda N, Ebert DL, Doers TM, Newman M, Hasler-Rapacz J, Attie AD, Rapacz J, Smithies O. Molecular genetics of the apolipoprotein B gene in pigs in relation to atherosclerosis. Gene. 70: 213-29. PMID 2905687  0.96
1988 Lyons KM, Stein JH, Smithies O. Length polymorphisms in human proline-rich protein genes generated by intragenic unequal crossing over. Genetics. 120: 267-78. PMID 2851479  0.96
1987 Doetschman T, Gregg RG, Maeda N, Hooper ML, Melton DW, Thompson S, Smithies O. Targetted correction of a mutant HPRT gene in mouse embryonic stem cells. Nature. 330: 576-8. PMID 3683574 DOI: 10.1038/330576a0  0.96
1987 Saitoh E, Kim HS, Smithies O, Maeda N. Human cysteine-proteinase inhibitors: nucleotide sequence analysis of three members of the cystatin gene family. Gene. 61: 329-38. PMID 3446578  0.96
1987 Skoultchi AI, Nandi A, Roginski RS, Gregg RG, Smithies O. Expression of genes inserted at the human beta-globin locus by homologous recombination. Progress in Clinical and Biological Research. 251: 581-94. PMID 2829231  0.96
1987 Song KY, Schwartz F, Maeda N, Smithies O, Kucherlapati R. Accurate modification of a chromosomal plasmid by homologous recombination in human cells. Proceedings of the National Academy of Sciences of the United States of America. 84: 6820-4. PMID 2821545 DOI: 10.1073/pnas.84.19.6820  0.96
1986 Gregg RG, Smithies O. Targeted modification of human chromosomal genes. Cold Spring Harbor Symposia On Quantitative Biology. 51: 1093-9. PMID 3472754  0.96
1986 Boggs SS, Gregg RG, Borenstein N, Smithies O. Efficient transformation and frequent single-site, single-copy insertion of DNA can be obtained in mouse erythroleukemia cells transformed by electroporation. Experimental Hematology. 14: 988-94. PMID 3464450  0.96
1986 Maeda N, Smithies O. The evolution of multigene families: human haptoglobin genes. Annual Review of Genetics. 20: 81-108. PMID 2880559 DOI: 10.1146/annurev.ge.20.120186.000501  0.96
1986 Maeda N, McEvoy SM, Harris HF, Huisman TH, Smithies O. Polymorphisms in the human haptoglobin gene cluster: chromosomes with multiple haptoglobin-related (Hpr) genes. Proceedings of the National Academy of Sciences of the United States of America. 83: 7395-9. PMID 2876426 DOI: 10.1073/pnas.83.19.7395  0.96
1986 Henthorn PS, Mager DL, Huisman TH, Smithies O. A gene deletion ending within a complex array of repeated sequences 3' to the human beta-globin gene cluster. Proceedings of the National Academy of Sciences of the United States of America. 83: 5194-8. PMID 2425363 DOI: 10.1073/pnas.83.14.5194  0.4
1986 Smithies O, Powers PA. Gene conversions and their relation to homologous chromosome pairing. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 312: 291-302. PMID 2421362  0.96
1986 Powers PA, Smithies O. Short gene conversions in the human fetal globin gene region: a by-product of chromosome pairing during meiosis? Genetics. 112: 343-58. PMID 2416635  0.96
1985 Li Q, Powers PA, Smithies O. Nucleotide sequence of 16-kilobase pairs of DNA 5' to the human epsilon-globin gene. The Journal of Biological Chemistry. 260: 14901-10. PMID 4066658  0.96
1985 Smithies O, Gregg RG, Boggs SS, Koralewski MA, Kucherlapati RS. Insertion of DNA sequences into the human chromosomal beta-globin locus by homologous recombination. Nature. 317: 230-4. PMID 2995814 DOI: 10.1038/317230a0  0.96
1985 Maeda N, Kim HS, Azen EA, Smithies O. Differential RNA splicing and post-translational cleavages in the human salivary proline-rich protein gene system. The Journal of Biological Chemistry. 260: 11123-30. PMID 2993301  0.96
1985 Henthorn PS, Smithies O, Nakatsuji T, Felice AE, Gardiner MB, Reese AL, Huisman TH. (A gamma delta beta)0-Thalassaemia in Blacks is due to a deletion of 34 kbp of DNA. British Journal of Haematology. 59: 343-56. PMID 2578804 DOI: 10.1111/j.1365-2141.1985.tb02999.x  0.4
1984 Devereux J, Haeberli P, Smithies O. A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Research. 12: 387-95. PMID 6546423  0.96
1984 Kucherlapati RS, Eves EM, Song KY, Morse BS, Smithies O. Homologous recombination between plasmids in mammalian cells can be enhanced by treatment of input DNA. Proceedings of the National Academy of Sciences of the United States of America. 81: 3153-7. PMID 6328502  0.96
1984 Maeda N, Yang F, Barnett DR, Bowman BH, Smithies O. Duplication within the haptoglobin Hp2 gene. Nature. 309: 131-5. PMID 6325933 DOI: 10.1038/309131a0  0.96
1984 Powers PA, Altay C, Huisman TH, Smithies O. Two novel arrangements of the human fetal globin genes: G gamma-G gamma and A gamma-A gamma. Nucleic Acids Research. 12: 7023-34. PMID 6091051 DOI: 10.1093/nar/12.18.7023  0.96
1984 Azen E, Lyons KM, McGonigal T, Barrett NL, Clements LS, Maeda N, Vanin EF, Carlson DM, Smithies O. Clones from the human gene complex coding for salivary proline-rich proteins. Proceedings of the National Academy of Sciences of the United States of America. 81: 5561-5. PMID 6089212 DOI: 10.1073/pnas.81.17.5561  0.96
1983 Roginski RS, Skoultchi AI, Henthorn P, Smithies O, Hsiung N, Kucherlapati R. Coordinate modulation of transfected HSV thymidine kinase and human globin genes. Cell. 35: 149-55. PMID 6313221 DOI: 10.1016/0092-8674(83)90217-9  0.96
1983 Maeda N, Bliska JB, Smithies O. Recombination and balanced chromosome polymorphism suggested by DNA sequences 5' to the human delta-globin gene. Proceedings of the National Academy of Sciences of the United States of America. 80: 5012-6. PMID 6308666  0.96
1981 Smithies O, Engels WR, Devereux JR, Slightom JL, Shen S. Base substitutions, length differences and DNA strand asymmetries in the human G gamma and A gamma fetal globin gene region. Cell. 26: 345-53. PMID 6173131 DOI: 10.1016/0092-8674(81)90203-8  0.96
1980 Efstratiadis A, Posakony JW, Maniatis T, Lawn RM, O'Connell C, Spritz RA, DeRiel JK, Forget BG, Weissman SM, Slightom JL, Blechl AE, Smithies O, Baralle FE, Shoulders CC, Proudfoot NJ. The structure and evolution of the human beta-globin gene family. Cell. 21: 653-68. PMID 6985477 DOI: 10.1016/0092-8674(80)90429-8  0.96
1980 Vanin EF, Goldberg GI, Tucker PW, Smithies O. A mouse alpha-globin-related pseudogene lacking intervening sequences. Nature. 286: 222-6. PMID 6250049 DOI: 10.1038/286222a0  0.96
1978 Smithies O, Blechl AE, Denniston-Thompson K, Newell N, Richards JE, Slightom JL, Tucker PW, Blattner FR. Cloning human fetal gamma globin and mouse alpha-type globin DNA: characterization and partial sequencing. Science (New York, N.Y.). 202: 1284-9. PMID 725604 DOI: 10.1126/science.725604  0.96
1978 Blattner FR, Blechl AE, Denniston-Thompson K, Faber HE, Richards JE, Slightom JL, Tucker PW, Smithies O. Cloning human fetal gamma globin and mouse alpha-type globin DNA: preparation and screening of shotgun collections. Science (New York, N.Y.). 202: 1279-84. PMID 725603 DOI: 10.1126/science.725603  0.96
1975 Shinnick TM, Lund E, Smithies O, Blattner FR. Hybridization of labeled RNA to DNA in agarose gels. Nucleic Acids Research. 2: 1911-29. PMID 1103090 DOI: 10.1093/nar/2.10.1911  0.96
1973 Fett JW, Deutsch HF, Smithies O. Hinge-region deletion localized in the IgG-globulin Mcg. Immunochemistry. 10: 115-8. PMID 4727433 DOI: 10.1016/0019-2791(73)90238-3  0.96
1971 Sung MT, Dixon GH, Smithies O. Phosphorylation and synthesis of histones in regenerating rat liver. The Journal of Biological Chemistry. 246: 1358-64. PMID 5547589  0.96
1971 Gibson D, Levanon M, Smithies O. Heterogeneity of normal human immunoglobulin light chains. Nonallelic variation in the constant region of lambda chains. Biochemistry. 10: 3114-22. PMID 4108342  0.96
1969 Sung M, Smithies O. Differential elution of histones from gel-trapped nuclei. Biopolymers. 7: 39-58. PMID 5772420 DOI: 10.1002/bip.1969.360070105  0.96
1969 Azen EA, Smithies O, Hiller O. High-voltage starch-gel electrophoresis in the study of post-albumin proteins and C'3(beta 1-c-globulin) polymorphism. Biochemical Genetics. 3: 215-28. PMID 5409404 DOI: 10.1007/BF00521138  0.36
1968 Azen EA, Smithies O. Genetic polymorphism of C'3(beta1C-globulin) in human serum. Science (New York, N.Y.). 162: 905-7. PMID 4176438 DOI: 10.1126/science.162.3856.905  0.36
1966 Claflin AJ, Smithies O, Meyer RK. Antibody responses in bursa-deficient chickens. Journal of Immunology (Baltimore, Md. : 1950). 97: 693-9. PMID 4959015  0.96
1965 AZEN EA, ORR S, SMITHIES O. STARCH-GEL ELECTROPHORESIS OF ERYTHROCYTE STROMA. The Journal of Laboratory and Clinical Medicine. 65: 440-9. PMID 14261325  0.96
1959 Giblett ER, Hickman CG, Smithies O. Serum transferrins Nature. 183: 1589-1590. PMID 13666824 DOI: 10.1038/1831589a0  0.96
1948 OGSTON AG, SMITHIES O. Some thermodynamic and kinetic aspects of metabolic phosphorylation. Physiological Reviews. 28: 283-303. PMID 18874569  1
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