Jada Lewis - Publications

Affiliations: 
Neuroscience University of Florida, Gainesville, Gainesville, FL, United States 
Area:
Aging & Memory Loss,Neurodegeneration,Modeling & Therapeutic Trials for Neurodegenerative Diseases,Alzheimer’s and Parkinson’s Diseases, Frontotemporal Dementia,Amyotrophic Lateral Sclerosis

133 high-probability publications. We are testing a new system for linking publications to authors. You can help! If you notice any inaccuracies, please sign in and mark papers as correct or incorrect matches. If you identify any major omissions or other inaccuracies in the publication list, please let us know.

Year Citation  Score
2022 Moore BD, Levites Y, Xu G, Hampton H, Adamo MF, Croft CL, Futch HS, Moran C, Fromholt S, Janus C, Prokop S, Dickson D, Lewis J, Giasson BI, Golde TE, et al. Soluble brain homogenates from diverse human and mouse sources preferentially seed diffuse Aβ plaque pathology when injected into newborn mouse hosts. Free Neuropathology. 3. PMID 35494163 DOI: 10.17879/freeneuropathology-2022-3766  0.328
2022 Xu G, Ulm BS, Howard J, Fromholt SE, Lu Q, Lee BB, Walker A, Borchelt DR, Lewis J. TAPPing into the potential of inducible tau/APP transgenic mice. Neuropathology and Applied Neurobiology. PMID 35067965 DOI: 10.1111/nan.12791  0.348
2020 Xu G, Fromholt SE, Chakrabarty P, Zhu F, Liu X, Pace MC, Koh J, Golde TE, Levites Y, Lewis J, Borchelt DR. Diversity in Aβ deposit morphology and secondary proteome insolubility across models of Alzheimer-type amyloidosis. Acta Neuropathologica Communications. 8: 43. PMID 32252825 DOI: 10.1186/S40478-020-00911-Y  0.405
2020 Koller EJ, Gonzalez De La Cruz E, Weinrich M, Williams T, Cruz PE, Ryu D, Golde TE, Sullivan PM, Lewis J, Borchelt DR, Chakrabarty P. Intracerebral Expression of AAV-APOE4 Is Not Sufficient to Alter Tau Burden in Two Distinct Models of Tauopathy. Molecular Neurobiology. PMID 31903524 DOI: 10.1007/S12035-019-01859-4  0.486
2018 Bardai FH, Ordonez DG, Bailey RM, Hamm M, Lewis J, Feany MB. Lrrk promotes tau neurotoxicity through dysregulation of actin and mitochondrial dynamics. Plos Biology. 16: e2006265. PMID 30571694 DOI: 10.1371/Journal.Pbio.2006265  0.612
2018 Moloney C, Rayaprolu S, Howard J, Fromholt S, Brown H, Collins M, Cabrera M, Duffy C, Siemienski Z, Miller D, Borchelt DR, Lewis J. Analysis of spinal and muscle pathology in transgenic mice overexpressing wild-type and ALS-linked mutant MATR3. Acta Neuropathologica Communications. 6: 137. PMID 30563574 DOI: 10.1186/S40478-018-0631-0  0.803
2018 Hamm M, Ladd TB, Levites Y, Golde TE, Giasson BI, Lewis J. Designing antibodies against LRRK2-targeted tau epitopes. Plos One. 13: e0204367. PMID 30261006 DOI: 10.1371/Journal.Pone.0204367  0.385
2018 Pace MC, Xu G, Fromholt S, Howard J, Crosby K, Giasson BI, Lewis J, Borchelt DR. Changes in proteome solubility indicate widespread proteostatic disruption in mouse models of neurodegenerative disease. Acta Neuropathologica. PMID 30140941 DOI: 10.1007/S00401-018-1895-Y  0.442
2018 Rayaprolu S, Seven YB, Howard J, Duffy C, Altshuler M, Moloney C, Giasson BI, Lewis J. Partial loss of ATP13A2 causes selective gliosis independent of robust lipofuscinosis. Molecular and Cellular Neurosciences. PMID 29859891 DOI: 10.1016/J.Mcn.2018.05.009  0.793
2018 Pace MC, Xu G, Fromholt S, Howard J, Giasson BI, Lewis J, Borchelt DR. Differential induction of mutant SOD1 misfolding and aggregation by tau and α-synuclein pathology. Molecular Neurodegeneration. 13: 23. PMID 29776378 DOI: 10.1186/S13024-018-0253-9  0.361
2018 Iradi MCG, Triplett JC, Thomas JD, Davila R, Crown AM, Brown H, Lewis J, Swanson MS, Xu G, Rodriguez-Lebron E, Borchelt DR. Characterization of gene regulation and protein interaction networks for Matrin 3 encoding mutations linked to amyotrophic lateral sclerosis and myopathy. Scientific Reports. 8: 4049. PMID 29511296 DOI: 10.1038/S41598-018-21371-4  0.343
2017 Moloney C, Rayaprolu S, Howard J, Fromholt S, Brown H, Collins M, Cabrera M, Duffy C, Siemienski Z, Miller D, Swanson MS, Notterpek L, Borchelt DR, Lewis J. Retraction Note: Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype. Acta Neuropathologica Communications. 5: 97. PMID 29237481 DOI: 10.1186/S40478-017-0502-0  0.797
2017 Khare S, Nick JA, Zhang Y, Galeano K, Butler B, Khoshbouei H, Rayaprolu S, Hathorn T, Ranum LPW, Smithson L, Golde TE, Paucar M, Morse R, Raff M, Simon J, ... ... Lewis J, et al. A KCNC3 mutation causes a neurodevelopmental, non-progressive SCA13 subtype associated with dominant negative effects and aberrant EGFR trafficking. Plos One. 12: e0173565. PMID 28467418 DOI: 10.1371/Journal.Pone.0173565  0.706
2016 Moloney C, Rayaprolu S, Howard J, Fromholt S, Brown H, Collins M, Cabrera M, Duffy C, Siemienski Z, Miller D, Swanson MS, Notterpek L, Borchelt DR, Lewis J. Transgenic mice overexpressing the ALS-linked protein Matrin 3 develop a profound muscle phenotype. Acta Neuropathologica Communications. 4: 122. PMID 27863507 DOI: 10.1186/S40478-016-0393-5  0.801
2016 Fromholt S, Reitano C, Brown H, Lewis J, Borchelt DR. Generation of a new transgenic mouse model for assessment of tau gene silencing therapies. Alzheimer's Research & Therapy. 8: 36. PMID 27593210 DOI: 10.1186/S13195-016-0202-1  0.386
2016 Rayaprolu S, D'Alton S, Crosby K, Moloney C, Howard J, Duffy C, Cabrera M, Siemienski Z, Hernandez AR, Gallego-Iradi C, Borchelt DR, Lewis J. Heterogeneity of Matrin 3 in the developing and aging murine central nervous system. The Journal of Comparative Neurology. PMID 26878116 DOI: 10.1002/Cne.23986  0.772
2015 Lewis J, Dickson DW. Propagation of tau pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies. Acta Neuropathologica. PMID 26576562 DOI: 10.1007/S00401-015-1507-Z  0.531
2015 Gallego-Iradi MC, Clare AM, Brown HH, Janus C, Lewis J, Borchelt DR. Subcellular Localization of Matrin 3 Containing Mutations Associated with ALS and Distal Myopathy. Plos One. 10: e0142144. PMID 26528920 DOI: 10.1371/Journal.Pone.0142144  0.348
2015 Li A, Ceballos-Diaz C, DiNunno N, Levites Y, Cruz PE, Lewis J, Golde TE, Chakrabarty P. IFN-γ promotes τ phosphorylation without affecting mature tangles. Faseb Journal : Official Publication of the Federation of American Societies For Experimental Biology. PMID 26156074 DOI: 10.1096/Fj.15-275834  0.323
2015 Hamm M, Bailey R, Shaw G, Yen SH, Lewis J, Giasson BI. Physiologically relevant factors influence tau phosphorylation by leucine-rich repeat kinase 2. Journal of Neuroscience Research. PMID 26123245 DOI: 10.1002/Jnr.23614  0.579
2015 D'Alton S, Altshuler M, Lewis J. Studies of alternative isoforms provide insight into TDP-43 autoregulation and pathogenesis. Rna (New York, N.Y.). 21: 1419-32. PMID 26089325 DOI: 10.1261/Rna.047647.114  0.725
2015 Chakrabarty P, Hudson Iii VJ, Sacino AN, Brooks MM, D'Alton S, Lewis J, Golde TE, Giasson BI. Inefficient induction and spread of seeded tau pathology in P301L mouse model of tauopathy suggests inherent physiological barriers to transmission. Acta Neuropathologica. 130: 303-5. PMID 25982997 DOI: 10.1007/S00401-015-1444-X  0.773
2014 D'Alton S, Lewis J. Understanding the role of progranulin in Alzheimer's disease. Nature Medicine. 20: 1099-100. PMID 25295938 DOI: 10.1038/Nm.3712  0.741
2014 D'Alton S, Lewis J. Therapeutic and diagnostic challenges for frontotemporal dementia. Frontiers in Aging Neuroscience. 6: 204. PMID 25191265 DOI: 10.3389/Fnagi.2014.00204  0.742
2014 Stoica R, De Vos KJ, Paillusson S, Mueller S, Sancho RM, Lau KF, Vizcay-Barrena G, Lin WL, Xu YF, Lewis J, Dickson DW, Petrucelli L, Mitchell JC, Shaw CE, Miller CC. ER-mitochondria associations are regulated by the VAPB-PTPIP51 interaction and are disrupted by ALS/FTD-associated TDP-43. Nature Communications. 5: 3996. PMID 24893131 DOI: 10.1038/Ncomms4996  0.395
2014 Schirer Y, Malishkevich A, Ophir Y, Lewis J, Giladi E, Gozes I. Novel marker for the onset of frontotemporal dementia: early increase in activity-dependent neuroprotective protein (ADNP) in the face of Tau mutation. Plos One. 9: e87383. PMID 24489906 DOI: 10.1371/Journal.Pone.0087383  0.438
2014 D'Alton S, Altshuler M, Cannon A, Dickson DW, Petrucelli L, Lewis J. Divergent phenotypes in mutant TDP-43 transgenic mice highlight potential confounds in TDP-43 transgenic modeling. Plos One. 9: e86513. PMID 24466128 DOI: 10.1371/Journal.Pone.0086513  0.825
2014 Frost B, Hemberg M, Lewis J, Feany MB. Tau promotes neurodegeneration through global chromatin relaxation. Nature Neuroscience. 17: 357-66. PMID 24464041 DOI: 10.1038/Nn.3639  0.436
2014 Bailey RM, Howard J, Knight J, Sahara N, Dickson DW, Lewis J. Effects of the C57BL/6 strain background on tauopathy progression in the rTg4510 mouse model. Molecular Neurodegeneration. 9: 8. PMID 24428919 DOI: 10.1186/1750-1326-9-8  0.687
2014 Sahara N, Perez PD, Lin WL, Dickson DW, Ren Y, Zeng H, Lewis J, Febo M. Age-related decline in white matter integrity in a mouse model of tauopathy: an in vivo diffusion tensor magnetic resonance imaging study. Neurobiology of Aging. 35: 1364-74. PMID 24411290 DOI: 10.1016/J.Neurobiolaging.2013.12.009  0.515
2014 Ren Y, Sahara N, Giasson B, Lewis J. Tauopathy Mouse Models Movement Disorders: Genetics and Models: Second Edition. 849-855. DOI: 10.1016/B978-0-12-405195-9.00055-X  0.353
2013 Zu T, Liu Y, Bañez-Coronel M, Reid T, Pletnikova O, Lewis J, Miller TM, Harms MB, Falchook AE, Subramony SH, Ostrow LW, Rothstein JD, Troncoso JC, Ranum LP. RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia. Proceedings of the National Academy of Sciences of the United States of America. 110: E4968-77. PMID 24248382 DOI: 10.1073/Pnas.1315438110  0.355
2013 Golde TE, Lewis J, McFarland NR. Anti-tau antibodies: hitting the target. Neuron. 80: 254-6. PMID 24139027 DOI: 10.1016/J.Neuron.2013.10.009  0.392
2013 Bailey RM, Covy JP, Melrose HL, Rousseau L, Watkinson R, Knight J, Miles S, Farrer MJ, Dickson DW, Giasson BI, Lewis J. LRRK2 phosphorylates novel tau epitopes and promotes tauopathy. Acta Neuropathologica. 126: 809-27. PMID 24113872 DOI: 10.1007/S00401-013-1188-4  0.644
2013 Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, ... ... Lewis J, et al. Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls. Neuron. 79: 1094-108. PMID 24050400 DOI: 10.1016/J.Neuron.2013.07.037  0.357
2013 Rutherford NJ, Lewis J, Clippinger AK, Thomas MA, Adamson J, Cruz PE, Cannon A, Xu G, Golde TE, Shaw G, Borchelt DR, Giasson BI. Unbiased screen reveals ubiquilin-1 and -2 highly associated with huntingtin inclusions. Brain Research. 1524: 62-73. PMID 23774650 DOI: 10.1016/J.Brainres.2013.06.006  0.616
2013 Lincoln S, Allen M, Cox CL, Walker LP, Malphrus K, Qiu Y, Nguyen T, Rowley C, Kouri N, Crook J, Pankratz VS, Younkin S, Younkin L, Carrasquillo M, Zou F, ... ... Lewis JM, et al. LRRTM3 interacts with APP and BACE1 and has variants associating with late-onset Alzheimer's disease (LOAD). Plos One. 8: e64164. PMID 23750206 DOI: 10.1371/Journal.Pone.0064164  0.417
2013 Sacino AN, Thomas MA, Ceballos-Diaz C, Cruz PE, Rosario AM, Lewis J, Giasson BI, Golde TE. Conformational templating of α-synuclein aggregates in neuronal-glial cultures. Molecular Neurodegeneration. 8: 17. PMID 23714769 DOI: 10.1186/1750-1326-8-17  0.341
2013 Clippinger AK, D'Alton S, Lin WL, Gendron TF, Howard J, Borchelt DR, Cannon A, Carlomagno Y, Chakrabarty P, Cook C, Golde TE, Levites Y, Ranum L, Schultheis PJ, Xu G, ... ... Lewis J, et al. Robust cytoplasmic accumulation of phosphorylated TDP-43 in transgenic models of tauopathy. Acta Neuropathologica. 126: 39-50. PMID 23666556 DOI: 10.1007/S00401-013-1123-8  0.828
2013 Golde TE, Borchelt DR, Giasson BI, Lewis J. Thinking laterally about neurodegenerative proteinopathies. The Journal of Clinical Investigation. 123: 1847-55. PMID 23635781 DOI: 10.1172/Jci66029  0.33
2013 Schultheis PJ, Fleming SM, Clippinger AK, Lewis J, Tsunemi T, Giasson B, Dickson DW, Mazzulli JR, Bardgett ME, Haik KL, Ekhator O, Chava AK, Howard J, Gannon M, Hoffman E, et al. Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits. Human Molecular Genetics. 22: 2067-82. PMID 23393156 DOI: 10.1093/Hmg/Ddt057  0.554
2013 Perez PD, Hall G, Kimura T, Ren Y, Bailey RM, Lewis J, Febo M, Sahara N. In vivo functional brain mapping in a conditional mouse model of human tauopathy (tauP301L) reveals reduced neural activity in memory formation structures. Molecular Neurodegeneration. 8: 9. PMID 23379588 DOI: 10.1186/1750-1326-8-9  0.642
2013 Sahara N, DeTure M, Ren Y, Ebrahim AS, Kang D, Knight J, Volbracht C, Pedersen JT, Dickson DW, Yen SH, Lewis J. Characteristics of TBS-extractable hyperphosphorylated tau species: aggregation intermediates in rTg4510 mouse brain. Journal of Alzheimer's Disease : Jad. 33: 249-63. PMID 22941973 DOI: 10.3233/Jad-2012-121093  0.517
2012 Gass J, Lee WC, Cook C, Finch N, Stetler C, Jansen-West K, Lewis J, Link CD, Rademakers R, Nykjær A, Petrucelli L. Progranulin regulates neuronal outgrowth independent of sortilin. Molecular Neurodegeneration. 7: 33. PMID 22781549 DOI: 10.1186/1750-1326-7-33  0.527
2012 Smith KR, Damiano J, Franceschetti S, Carpenter S, Canafoglia L, Morbin M, Rossi G, Pareyson D, Mole SE, Staropoli JF, Sims KB, Lewis J, Lin WL, Dickson DW, Dahl HH, et al. Strikingly different clinicopathological phenotypes determined by progranulin-mutation dosage. American Journal of Human Genetics. 90: 1102-7. PMID 22608501 DOI: 10.1016/J.Ajhg.2012.04.021  0.489
2012 Cannon A, Yang B, Knight J, Farnham IM, Zhang Y, Wuertzer CA, D'Alton S, Lin WL, Castanedes-Casey M, Rousseau L, Scott B, Jurasic M, Howard J, Yu X, Bailey R, ... ... Lewis J, et al. Neuronal sensitivity to TDP-43 overexpression is dependent on timing of induction. Acta Neuropathologica. 123: 807-23. PMID 22539017 DOI: 10.1007/S00401-012-0979-3  0.813
2012 Bailey R, Cannon A, Melrose H, Farrer M, Dickson D, Lewis J. P1-195: LRRK2 modulation of neuropathology in a mouse model of tauopathy Alzheimer's & Dementia. 8: P175-P175. DOI: 10.1016/J.Jalz.2012.05.473  0.707
2012 Lewis J, Cannon A, D'Alton S, Dickson DW, Petrucelli L. S5-02-02: Lessons learned from emerging mouse models of TDP-43 proteinopathy Alzheimer's & Dementia. 8: P725-P725. DOI: 10.1016/J.Jalz.2012.05.1949  0.76
2012 D'Alton S, Altshuler M, Cannon A, Dickson D, Petrucelli L, Lewis J. O4-07-06: Influence on phenotype of the postnatal developmental period in mice expressing human M337V TDP-43 Alzheimer's & Dementia. 8: P628-P629. DOI: 10.1016/J.Jalz.2012.05.1676  0.793
2011 Xu YF, Zhang YJ, Lin WL, Cao X, Stetler C, Dickson DW, Lewis J, Petrucelli L. Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice. Molecular Neurodegeneration. 6: 73. PMID 22029574 DOI: 10.1186/1750-1326-6-73  0.601
2011 Crimins JL, Rocher AB, Peters A, Shultz P, Lewis J, Luebke JI. Homeostatic responses by surviving cortical pyramidal cells in neurodegenerative tauopathy. Acta Neuropathologica. 122: 551-64. PMID 21968531 DOI: 10.1007/S00401-011-0877-0  0.367
2011 Ludvigson AE, Luebke JI, Lewis J, Peters A. Structural abnormalities in the cortex of the rTg4510 mouse model of tauopathy: a light and electron microscopy study. Brain Structure & Function. 216: 31-42. PMID 21152933 DOI: 10.1007/S00429-010-0295-4  0.451
2011 Morgan D, Munireddy S, Alamed J, DeLeon J, Diamond DM, Bickford P, Hutton M, Lewis J, McGowan E, Gordon MN. Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice Advances in Alzheimer's Disease. 1: 129-138. DOI: 10.3233/978-1-60750-733-8-129  0.543
2011 D'Alton S, Altshuler M, Lewis J. P4-139: Characterisation of alternative isoforms of TDP-43 Alzheimer's & Dementia. 7: S752-S752. DOI: 10.1016/J.Jalz.2011.05.2161  0.703
2011 Abisambra J, Cannon A, O'Leary J, Brady S, Espinosa A, Jinwal U, Koren J, Blair L, Lewis J, Dickey C. O4-04-08: Neuronal tau-specific stress induction of molecular chaperones: The failure of a coping mechanism Alzheimer's & Dementia. 7: S691-S691. DOI: 10.1016/J.Jalz.2011.05.1996  0.673
2011 Cannon A, Yang B, Knight J, Farnham M, Zhang Y, Wuertzer C, D'Alton S, Howard J, Lin W, Scott B, Jurasic M, Yu X, Bailey R, Dickson D, Petrucelli L, ... Lewis J, et al. P3-006: Neurons during early development are highly vulnerable to TDP-43 dysregulation Alzheimer's & Dementia. 7: S517-S517. DOI: 10.1016/J.Jalz.2011.05.1445  0.765
2011 Bailey R, Howard J, Knight J, Dickson D, Lewis J. P3-003: Effect of strain background on pathology progression in tau mouse model Alzheimer's & Dementia. 7: S515-S516. DOI: 10.1016/J.Jalz.2011.05.1442  0.64
2011 Sahara N, Melrose H, D'alton S, Lewis J. Transgenic Animal Models of Proteinopathies Neurodegeneration: the Molecular Pathology of Dementia and Movement Disorders: Second Edition. 26-36. DOI: 10.1002/9781444341256.ch7  0.715
2010 Lewis J, Golde TE. Sorting out frontotemporal dementia? Neuron. 68: 601-3. PMID 21092851 DOI: 10.1016/J.Neuron.2010.11.014  0.358
2010 Sahara N, Lewis J. Amyloid precursor protein and tau transgenic models of Alzheimer's disease: insights from the past and directions for the future. Future Neurology. 5: 411-420. PMID 20730022 DOI: 10.2217/Fnl.10.10  0.444
2010 Xu YF, Gendron TF, Zhang YJ, Lin WL, D'Alton S, Sheng H, Casey MC, Tong J, Knight J, Yu X, Rademakers R, Boylan K, Hutton M, McGowan E, Dickson DW, ... Lewis J, et al. Wild-type human TDP-43 expression causes TDP-43 phosphorylation, mitochondrial aggregation, motor deficits, and early mortality in transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 30: 10851-9. PMID 20702714 DOI: 10.1523/Jneurosci.1630-10.2010  0.83
2010 Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, ... ... Lewis J, et al. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging. The American Journal of Pathology. 177: 311-24. PMID 20522652 DOI: 10.2353/Ajpath.2010.090915  0.658
2010 Golde TE, Petrucelli L, Lewis J. Targeting Abeta and tau in Alzheimer's disease, an early interim report. Experimental Neurology. 223: 252-66. PMID 19716367 DOI: 10.1016/J.Expneurol.2009.07.035  0.395
2010 Rocher AB, Crimins JL, Amatrudo JM, Kinson MS, Todd-Brown MA, Lewis J, Luebke JI. Structural and functional changes in tau mutant mice neurons are not linked to the presence of NFTs Experimental Neurology. 223: 385-393. PMID 19665462 DOI: 10.1016/J.Expneurol.2009.07.029  0.423
2010 Ahmed Z, Sheng H, Xu YF, Lin WL, Innes AE, Gass J, Yu X, Wuertzer CA, Hou H, Chiba S, Yamanouchi K, Leissring M, Petrucelli L, Nishihara M, Hutton ML, ... ... Lewis J, et al. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggest a role for progranulin in successful aging (American Journal of Pathology (2010), 177, (311-324)) American Journal of Pathology. 177: 2146. DOI: 10.2353/Ajpath.2010.100772  0.614
2010 Sahara N, DeTure M, Abdul-Shukkur E, Christensen S, Kang D, Knight J, Volbracht C, Petrucelli L, Yen S, Lewis J. P1-371: Characteristics of cytosolic hyperphosphorylated tau species in rTg4510 mouse brain Alzheimer's & Dementia. 6: S280-S281. DOI: 10.1016/J.Jalz.2010.05.925  0.346
2010 Xu Y, Gendron T, Zhang Y, Lin W, D'Alton S, Sheng H, Crook R, Casey MC, Tong J, Knight J, Yu X, Rademakers R, Boylan K, Hutton M, McGowan E, ... ... Lewis J, et al. P1-185: Wild-type human TDP-43 induces mitochondrial abnormalities and axonal degeneration in transgenic mice Alzheimer's & Dementia. 6: S227-S227. DOI: 10.1016/J.Jalz.2010.05.735  0.795
2010 Cannon AD, Zhang Y, Knight J, Xu Y, Dickson DW, Petrucelli L, Lewis J. P1-179: Inducible expression of wild-type TDP-43 is toxic to mouse hippocampal and cortical neurons Alzheimer's & Dementia. 6: S225-S226. DOI: 10.1016/J.Jalz.2010.05.729  0.471
2010 Gass JM, Cook C, Rademakers R, Lewis J, Petrucelli L. O1-07-02: Loss of progranulin and its impact on neuronal function Alzheimer's & Dementia. 6: S83-S83. DOI: 10.1016/J.Jalz.2010.05.250  0.462
2010 Ahmed Z, Sheng H, Xu Y, Lin W, Innes AE, Yu X, Hou H, Chiba S, Yamanouchi K, Petrucelli L, Nishihara M, Hutton ML, McGowan E, Dickson DW, Lewis J. Accelerated lipofuscinosis and ubiquitination in granulin knockout mice suggests a role for progranulin in successful aging Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.249  0.495
2010 Lewis J, Xu Y, Cannon A, Zhang Y, Lin W, Hutton M, McGowan E, Dickson DW, Petrucelli L. O1-04-04: TDP-43 mouse models: Tools toward understanding the normal and disease roles for TDP-43 Alzheimer's & Dementia. 6: S77-S77. DOI: 10.1016/J.Jalz.2010.05.228  0.688
2010 D'Alton S, Xu Y, Zhang Y, Dickson DW, Lewis J, Petrucelli L. Gene expression analysis of TDP-43 transgenic mice Alzheimers & Dementia. 6. DOI: 10.1016/J.Jalz.2010.05.1273  0.77
2009 Cook C, Gass J, Dunmore J, Tong J, Taylor J, Eriksen J, McGowan E, Lewis J, Johnston J, Petrucelli L. Aging is not associated with proteasome impairment in UPS reporter mice. Plos One. 4: e5888. PMID 19517018 DOI: 10.1371/Journal.Pone.0005888  0.406
2009 Dickey C, Kraft C, Jinwal U, Koren J, Johnson A, Anderson L, Lebson L, Lee D, Dickson D, de Silva R, Binder LI, Morgan D, Lewis J. Aging analysis reveals slowed tau turnover and enhanced stress response in a mouse model of tauopathy. The American Journal of Pathology. 174: 228-38. PMID 19074615 DOI: 10.2353/Ajpath.2009.080764  0.721
2009 Lewis JM, Ahmed Z, Sheng H, Xu Y, Lin W, Innes A, Hou H, Hutton ML, McGowan E, Dickson DW. O4-06-01: Neuropathological characterization of progranulin-deficient mice: Accelerated lipofuscin accumulation suggests a role for progranulin in successful aging Alzheimer's & Dementia. 5: P161-P162. DOI: 10.1016/J.Jalz.2009.05.558  0.415
2009 Cannon AD, De Ture M, Knight J, Alosilla D, Dickson DW, Sahara N, Volbracht C, Lewis J. P3-198: Induction of mutant tau expression in aged rTg4510 mice does not rapidly induce tauopathy Alzheimer's & Dementia. 5: P400-P401. DOI: 10.1016/J.Jalz.2009.04.1072  0.547
2009 Barten DM, Meredith JE, Andorfer C, Polson C, Hoque N, Fiedler T, DeCarr LB, Goldstein M, Raybon JJ, Donegan M, Corradi J, Yang L, Janus C, Hutton M, Lewis J, et al. P3-187: Microtubule stabilizing agents as tools to explore the mechanism of Tau neurotoxicity in Alzheimer's disease and other Tauopathies Alzheimer's & Dementia. 5: P398-P398. DOI: 10.1016/J.Jalz.2009.04.1061  0.542
2009 Sahara N, Kang D, Yamashita S, Kimura T, Takashima A, Lewis J. P3-182: Examining the link between synaptosomal accumulation of tau protein and cognitive dysfunction Alzheimer's & Dementia. 5: P397-P397. DOI: 10.1016/J.Jalz.2009.04.1056  0.32
2008 Morgan D, Munireddy S, Alamed J, DeLeon J, Diamond DM, Bickford P, Hutton M, Lewis J, McGowan E, Gordon MN. Apparent behavioral benefits of tau overexpression in P301L tau transgenic mice. Journal of Alzheimer's Disease : Jad. 15: 605-14. PMID 19096159 DOI: 10.3233/Jad-2008-15407  0.627
2008 Lewis J, Melrose H, Bumcrot D, Hope A, Zehr C, Lincoln S, Braithwaite A, He Z, Ogholikhan S, Hinkle K, Kent C, Toudjarska I, Charisse K, Braich R, Pandey RK, et al. In vivo silencing of alpha-synuclein using naked siRNA. Molecular Neurodegeneration. 3: 19. PMID 18976489 DOI: 10.1186/1750-1326-3-19  0.331
2008 Eriksen JL, Zehr C, Lewis J. Biologic models of neurodegenerative disorders. Handbook of Clinical Neurology. 89: 173-88. PMID 18631742 DOI: 10.1016/S0072-9752(07)01216-X  0.381
2008 Vega IE, Traverso EE, Ferrer-Acosta Y, Matos E, Colon M, Gonzalez J, Dickson D, Hutton M, Lewis J, Yen SH. A novel calcium-binding protein is associated with tau proteins in tauopathy. Journal of Neurochemistry. 106: 96-106. PMID 18346207 DOI: 10.1111/J.1471-4159.2008.05339.X  0.653
2008 Spires-Jones TL, de Calignon A, Matsui T, Zehr C, Pitstick R, Wu HY, Osetek JD, Jones PB, Bacskai BJ, Feany MB, Carlson GA, Ashe KH, Lewis J, Hyman BT. In vivo imaging reveals dissociation between caspase activation and acute neuronal death in tangle-bearing neurons. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 28: 862-7. PMID 18216194 DOI: 10.1523/Jneurosci.3072-08.2008  0.32
2007 Bolmont T, Clavaguera F, Meyer-Luehmann M, Herzig MC, Radde R, Staufenbiel M, Lewis J, Hutton M, Tolnay M, Jucker M. Induction of tau pathology by intracerebral infusion of amyloid-beta -containing brain extract and by amyloid-beta deposition in APP x Tau transgenic mice. The American Journal of Pathology. 171: 2012-20. PMID 18055549 DOI: 10.2353/Ajpath.2007.070403  0.589
2007 Berger Z, Roder H, Hanna A, Carlson A, Rangachari V, Yue M, Wszolek Z, Ashe K, Knight J, Dickson D, Andorfer C, Rosenberry TL, Lewis J, Hutton M, Janus C. Accumulation of pathological tau species and memory loss in a conditional model of tauopathy. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 27: 3650-62. PMID 17409229 DOI: 10.1523/Jneurosci.0587-07.2007  0.799
2007 Lin W, Zehr C, Lewis J, Dickson DW. Progranulin is located in secretory granules and vesicles of neutrophils and macrophages by immunogold electron microscopy Journal of Neuropathology and Experimental Neurology. 66: 422. DOI: 10.1097/01.Jnen.0000268990.82771.11  0.343
2007 Lin W, Zehr C, Lewis J, Dickson DW. Progranulin is located in secretory granules and vesicles of neutrophils and macrophages by immunogold electron microscopy The Faseb Journal. 21. DOI: 10.1096/Fasebj.21.5.A22-B  0.343
2006 Katsuse O, Lin WL, Lewis J, Hutton ML, Dickson DW. Neurofibrillary tangle-related synaptic alterations of spinal motor neurons of P301L tau transgenic mice. Neuroscience Letters. 409: 95-9. PMID 17010516 DOI: 10.1016/J.Neulet.2006.09.021  0.622
2006 Le Corre S, Klafki HW, Plesnila N, Hübinger G, Obermeier A, Sahagún H, Monse B, Seneci P, Lewis J, Eriksen J, Zehr C, Yue M, McGowan E, Dickson DW, Hutton M, et al. An inhibitor of tau hyperphosphorylation prevents severe motor impairments in tau transgenic mice. Proceedings of the National Academy of Sciences of the United States of America. 103: 9673-8. PMID 16769887 DOI: 10.1073/Pnas.0602913103  0.656
2006 Lewis J, Zehr C, Knight J, Dickson DW, Hutton M, McGowan E. P1-117: Kinetics of tau suppression in the rTg4510 inducible model of tauopathy Alzheimer's & Dementia. 2: S129-S130. DOI: 10.1016/J.Jalz.2006.05.493  0.607
2006 Zehr C, Lin W, Knight J, Dickson DW, Hutton M, Lewis J. P1-102: Apoptosis of oligodendrocytes in an inducible model of tauopathy Alzheimer's & Dementia. 2: S125-S125. DOI: 10.1016/J.Jalz.2006.05.478  0.551
2006 Berger Z, Lewis J, Andorfer C, Yue M, Rosenberry T, Hutton M. P1-087: Identification of toxic tau species Alzheimer's & Dementia. 2: S120-S120. DOI: 10.1016/J.Jalz.2006.05.462  0.742
2006 Andorfer CA, Yue M, Janus C, Lewis J, Hutton M. P1-002: Synaptic degeneration and memory loss in a model of tauopathy Alzheimer's & Dementia. 2: S94-S95. DOI: 10.1016/J.Jalz.2006.05.377  0.473
2006 Lewis J, Zehr C, Andorfer C, Eriksen J, Knight J, Yue M, Robinson T, Berger Z, Hanna A, Dickson DW, Janus C, McGowan E, Hutton M. O4-05-01: Methods of cell death and recovery in the rTg4510 and iP301L inducible mouse models of tauopathy Alzheimer's & Dementia. 2: S84-S84. DOI: 10.1016/J.Jalz.2006.05.327  0.747
2006 Eriksen J, Zehr C, Berger Z, Robinson T, Lewis J, Hutton M. P3-293: Tau clearance through protein degradation pathways Alzheimer's & Dementia. 2: S461-S462. DOI: 10.1016/J.Jalz.2006.05.1562  0.748
2006 Hutton M, Melquist S, Baker M, Zehr C, McGowan E, Dickson D, Eriksen J, Ashe K, Stephan D, Lewis J. S2-02-06: The tauopathies: From genetics to animal models Alzheimer's & Dementia. 2: S26-S26. DOI: 10.1016/J.Jalz.2006.05.086  0.751
2005 Lin WL, Zehr C, Lewis J, Hutton M, Yen SH, Dickson DW. Progressive white matter pathology in the spinal cord of transgenic mice expressing mutant (P301L) human tau. Journal of Neurocytology. 34: 397-410. PMID 16902761 DOI: 10.1007/S11068-006-8726-0  0.609
2005 Ramsden M, Kotilinek L, Forster C, Paulson J, McGowan E, SantaCruz K, Guimaraes A, Yue M, Lewis J, Carlson G, Hutton M, Ashe KH. Age-dependent neurofibrillary tangle formation, neuron loss, and memory impairment in a mouse model of human tauopathy (P301L). The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 10637-47. PMID 16291936 DOI: 10.1523/Jneurosci.3279-05.2005  0.62
2005 Santacruz K, Lewis J, Spires T, Paulson J, Kotilinek L, Ingelsson M, Guimaraes A, DeTure M, Ramsden M, McGowan E, Forster C, Yue M, Orne J, Janus C, Mariash A, et al. Tau suppression in a neurodegenerative mouse model improves memory function. Science (New York, N.Y.). 309: 476-81. PMID 16020737 DOI: 10.1126/Science.1113694  0.576
2005 Noble W, Planel E, Zehr C, Olm V, Meyerson J, Suleman F, Gaynor K, Wang L, LaFrancois J, Feinstein B, Burns M, Krishnamurthy P, Wen Y, Bhat R, Lewis J, et al. Inhibition of glycogen synthase kinase-3 by lithium correlates with reduced tauopathy and degeneration in vivo. Proceedings of the National Academy of Sciences of the United States of America. 102: 6990-5. PMID 15867159 DOI: 10.1073/Pnas.0500466102  0.518
2005 Halverson RA, Lewis J, Frausto S, Hutton M, Muma NA. Tau protein is cross-linked by transglutaminase in P301L tau transgenic mice. The Journal of Neuroscience : the Official Journal of the Society For Neuroscience. 25: 1226-33. PMID 15689560 DOI: 10.1523/Jneurosci.3263-04.2005  0.625
2004 Sahara N, Vega IE, Ishizawa T, Lewis J, McGowan E, Hutton M, Dickson D, Yen SH. Phosphorylated p38MAPK specific antibodies cross-react with sarkosyl-insoluble hyperphosphorylated tau proteins. Journal of Neurochemistry. 90: 829-38. PMID 15287888 DOI: 10.1111/J.1471-4159.2004.02558.X  0.673
2004 Arendash GW, Lewis J, Leighty RE, McGowan E, Cracchiolo JR, Hutton M, Garcia MF. Multi-metric behavioral comparison of APPsw and P301L models for Alzheimer's disease: linkage of poorer cognitive performance to tau pathology in forebrain. Brain Research. 1012: 29-41. PMID 15158158 DOI: 10.1016/J.Brainres.2004.02.081  0.597
2004 Garcia MF, Gordon MN, Hutton M, Lewis J, McGowan E, Dickey CA, Morgan D, Arendash GW. The retinal degeneration (rd) gene seriously impairs spatial cognitive performance in normal and Alzheimer's transgenic mice. Neuroreport. 15: 73-7. PMID 15106834 DOI: 10.1097/00001756-200401190-00015  0.657
2004 Zehr C, Lewis J, McGowan E, Crook J, Lin WL, Godwin K, Knight J, Dickson DW, Hutton M. Apoptosis in oligodendrocytes is associated with axonal degeneration in P301L tau mice. Neurobiology of Disease. 15: 553-62. PMID 15056463 DOI: 10.1016/J.Nbd.2003.12.011  0.644
2004 Petrucelli L, Dickson D, Kehoe K, Taylor J, Snyder H, Grover A, De Lucia M, McGowan E, Lewis J, Prihar G, Kim J, Dillmann WH, Browne SE, Hall A, Voellmy R, et al. CHIP and Hsp70 regulate tau ubiquitination, degradation and aggregation. Human Molecular Genetics. 13: 703-14. PMID 14962978 DOI: 10.1093/Hmg/Ddh083  0.683
2004 Klein RL, Lin WL, Dickson DW, Lewis J, Hutton M, Duff K, Meyer EM, King MA. Rapid neurofibrillary tangle formation after localized gene transfer of mutated tau. The American Journal of Pathology. 164: 347-53. PMID 14695347 DOI: 10.1016/S0002-9440(10)63124-0  0.647
2004 Hutton M, Melrose H, Zehr C, McGowan E, Dickson DW, Yen S, Kehoe K, Taylor J, Eriksen J, Petrucelli L, Lewis J. P4-422 Mechanism of neurofibrillary degeneration in a mouse model of tauopathy and progress towards identification of a therapeutic target Neurobiology of Aging. 25: S594. DOI: 10.1016/S0197-4580(04)81978-X  0.603
2004 Horsburgh KJ, Pickford F, Kennedy L, Lewis J, Hutton M, McGowan E. P3-253 Temporal alterations in tau and apolipoprotein E after hippocampal denervation in mutant tau mice: a preliminary investigation Neurobiology of Aging. 25: S426-S427. DOI: 10.1016/S0197-4580(04)81403-9  0.596
2004 Petrucelli L, Taylor J, Kehoe K, Lewis J, McGowan E, Snyder H, Wolozin B, Dawson TM, Dillmann W, Voellmy R, Hutton M. P3-228 Chip and HSP70 regulate tau ubiquitination, degradation and aggregation Neurobiology of Aging. 25: S419-S420. DOI: 10.1016/S0197-4580(04)81378-2  0.529
2004 Bailey C, Pickord F, Lewis J, Heckman M, Yue M, O'Donnell K, Yu C, Hutton M, McGowan E. P2-095 The effect of ovariectomy on pathology and phenotype in Tau (P301L) transgenic mice Neurobiology of Aging. 25: S251. DOI: 10.1016/S0197-4580(04)80842-X  0.623
2004 Zehr C, Godwin K, Lin W, Dickson DW, McGowan E, Lewis J, Hutton M. P2-070 Axonal degeneration in P301L Tau transgenic mice Neurobiology of Aging. 25: S243-S244. DOI: 10.1016/S0197-4580(04)80817-0  0.634
2003 Lin WL, Lewis J, Yen SH, Hutton M, Dickson DW. Ultrastructural neuronal pathology in transgenic mice expressing mutant (P301L) human tau. Journal of Neurocytology. 32: 1091-105. PMID 15044841 DOI: 10.1023/B:Neur.0000021904.61387.95  0.661
2003 Ishizawa T, Sahara N, Ishiguro K, Kersh J, McGowan E, Lewis J, Hutton M, Dickson DW, Yen SH. Co-localization of glycogen synthase kinase-3 with neurofibrillary tangles and granulovacuolar degeneration in transgenic mice. The American Journal of Pathology. 163: 1057-67. PMID 12937146 DOI: 10.1016/S0002-9440(10)63465-7  0.689
2003 Lin WL, Lewis J, Yen SH, Hutton M, Dickson DW. Filamentous tau in oligodendrocytes and astrocytes of transgenic mice expressing the human tau isoform with the P301L mutation. The American Journal of Pathology. 162: 213-8. PMID 12507904 DOI: 10.1016/S0002-9440(10)63812-6  0.693
2002 Sahara N, Lewis J, DeTure M, McGowan E, Dickson DW, Hutton M, Yen SH. Assembly of tau in transgenic animals expressing P301L tau: alteration of phosphorylation and solubility. Journal of Neurochemistry. 83: 1498-508. PMID 12472903 DOI: 10.1046/J.1471-4159.2002.01241.X  0.666
2001 Hutton M, Lewis J, Dickson D, Yen SH, McGowan E. Analysis of tauopathies with transgenic mice. Trends in Molecular Medicine. 7: 467-70. PMID 11597522 DOI: 10.1016/S1471-4914(01)02123-2  0.682
2001 Lewis J, Dickson DW, Lin WL, Chisholm L, Corral A, Jones G, Yen SH, Sahara N, Skipper L, Yager D, Eckman C, Hardy J, Hutton M, McGowan E. Enhanced neurofibrillary degeneration in transgenic mice expressing mutant tau and APP. Science (New York, N.Y.). 293: 1487-91. PMID 11520987 DOI: 10.1126/Science.1058189  0.703
2001 Wittmann CW, Wszolek MF, Shulman JM, Salvaterra PM, Lewis J, Hutton M, Feany MB. Tauopathy in Drosophila: neurodegeneration without neurofibrillary tangles. Science (New York, N.Y.). 293: 711-4. PMID 11408621 DOI: 10.1126/Science.1062382  0.61
2000 van Slegtenhorst M, Lewis J, Hutton M. The molecular genetics of the tauopathies. Experimental Gerontology. 35: 461-71. PMID 10959034 DOI: 10.1016/S0531-5565(00)00114-5  0.58
2000 Lewis J, McGowan E, Rockwood J, Melrose H, Nacharaju P, Van Slegtenhorst M, Gwinn-Hardy K, Paul Murphy M, Baker M, Yu X, Duff K, Hardy J, Corral A, Lin WL, Yen SH, et al. Neurofibrillary tangles, amyotrophy and progressive motor disturbance in mice expressing mutant (P301L) tau protein. Nature Genetics. 25: 402-5. PMID 10932182 DOI: 10.1038/78078  0.72
2000 DeTure M, Ko LW, Yen S, Nacharaju P, Easson C, Lewis J, van Slegtenhorst M, Hutton M, Yen SH. Missense tau mutations identified in FTDP-17 have a small effect on tau-microtubule interactions. Brain Research. 853: 5-14. PMID 10627302 DOI: 10.1016/S0006-8993(99)02124-1  0.577
2000 Lewis J, Davies P, Yen S, Dickson DW, Hutton M. Neurofibrillary tangles, neuronal loss, and severe motor changes develop in transgenic mice expressing tau (4R0N) with the frontotemporal dementia with Parkinsonism linked to chromosome 17 (FTDP-17) mutation P301L Neurobiology of Aging. 21: 59. DOI: 10.1016/S0197-4580(00)82491-4  0.659
2000 Lewis J, Hutton M. Animal models of tau dysfunction Neuroscience News. 3: 63-72.  0.324
1999 Grover A, Houlden H, Baker M, Adamson J, Lewis J, Prihar G, Pickering-Brown S, Duff K, Hutton M. 5' splice site mutations in tau associated with the inherited dementia FTDP-17 affect a stem-loop structure that regulates alternative splicing of exon 10. The Journal of Biological Chemistry. 274: 15134-43. PMID 10329720 DOI: 10.1074/Jbc.274.21.15134  0.531
1999 Nacharaju P, Lewis J, Easson C, Yen S, Hackett J, Hutton M, Yen SH. Accelerated filament formation from tau protein with specific FTDP-17 missense mutations. Febs Letters. 447: 195-9. PMID 10214944 DOI: 10.1097/00005072-199905000-00157  0.569
1998 Whitney JB, Leder A, Lewis J, Popp RA, Paszty C, Rubin EM, Shehee WR, Townes TM, Smithies O. Rapid genotyping of mice with hemoglobinopathies and globin transgenes. Biochemical Genetics. 36: 65-77. PMID 9562907 DOI: 10.1023/A:1018752219810  0.585
1998 Lewis J, Yang B, Kim R, Sierakowska H, Kole R, Smithies O, Maeda N. A common human beta globin splicing mutation modeled in mice. Blood. 91: 2152-6. PMID 9490703 DOI: 10.1182/Blood.V91.6.2152.2152_2152_2156  0.722
1998 Lewis J, Yang B, Kim R, Sierakowska H, Kole R, Smithies O, Maeda N. A Common Human β Globin Splicing Mutation Modeled in Mice Blood. 91: 2152-2156. DOI: 10.1182/blood.V91.6.2152.2152_2152_2156  0.444
1996 Lewis J, Yang B, Detloff P, Smithies O. Gene modification via "plug and socket" gene targeting. The Journal of Clinical Investigation. 97: 3-5. PMID 8550847 DOI: 10.1172/Jci118403  0.701
1995 Yang B, Kirby S, Lewis J, Detloff PJ, Maeda N, Smithies O. A mouse model for beta 0-thalassemia. Proceedings of the National Academy of Sciences of the United States of America. 92: 11608-12. PMID 8524813 DOI: 10.1073/Pnas.92.25.11608  0.777
1994 Detloff PJ, Lewis J, John SW, Shehee WR, Langenbach R, Maeda N, Smithies O. Deletion and replacement of the mouse adult beta-globin genes by a "plug and socket" repeated targeting strategy. Molecular and Cellular Biology. 14: 6936-43. PMID 7935410 DOI: 10.1128/Mcb.14.10.6936  0.763
1993 Bird SR, Bailey R, Lewis J. Heart rates during competitive orienteering. British Journal of Sports Medicine. 27: 53-7. PMID 8457815  0.413
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